Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
AssayType |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 137660341 | 315362 | 0 | None | 141 | 2 | Human | 11.0 | pEC50 | = | 11 | Functional | ChEMBL | 1031 | 17 | 11 | 14 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC2CCCCC2)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4102192 | 315362 | 0 | None | 141 | 2 | Human | 11.0 | pEC50 | = | 11 | Functional | ChEMBL | 1031 | 17 | 11 | 14 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC2CCCCC2)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 2042 | 8014 | 41 | None | 1 | 5 | Human | 11.0 | pEC50 | = | 11 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.8b01691 | ||
| 2176 | 8014 | 41 | None | 1 | 5 | Human | 11.0 | pEC50 | = | 11 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.8b01691 | ||
| 439302 | 8014 | 41 | None | 1 | 5 | Human | 11.0 | pEC50 | = | 11 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.8b01691 | ||
| CHEMBL395429 | 8014 | 41 | None | 1 | 5 | Human | 11.0 | pEC50 | = | 11 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.8b01691 | ||
| 90680085 | 221000 | 0 | None | None | None | Human | 10.9 | pEC50 | = | 10.9 | Functional | ChEMBL | 951 | 18 | 12 | 14 | -3.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL3277916 | 221000 | 0 | None | None | None | Human | 10.9 | pEC50 | = | 10.9 | Functional | ChEMBL | 951 | 18 | 12 | 14 | -3.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 137654006 | 314620 | 0 | None | None | None | Human | 10.9 | pEC50 | = | 10.9 | Functional | ChEMBL | 986 | 17 | 13 | 14 | -5.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCC(=O)NC[C@@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4093931 | 314620 | 0 | None | None | None | Human | 10.9 | pEC50 | = | 10.9 | Functional | ChEMBL | 986 | 17 | 13 | 14 | -5.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCC(=O)NC[C@@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 137653847 | 314808 | 0 | None | 309 | 2 | Human | 10.9 | pEC50 | = | 10.9 | Functional | ChEMBL | 1005 | 17 | 11 | 14 | -2.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCCCC2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4095930 | 314808 | 0 | None | 309 | 2 | Human | 10.9 | pEC50 | = | 10.9 | Functional | ChEMBL | 1005 | 17 | 11 | 14 | -2.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCCCC2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 137645401 | 313783 | 0 | None | 181 | 2 | Human | 10.9 | pEC50 | = | 10.9 | Functional | ChEMBL | 977 | 16 | 11 | 14 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)NCC(N)=O)C(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4084223 | 313783 | 0 | None | 181 | 2 | Human | 10.9 | pEC50 | = | 10.9 | Functional | ChEMBL | 977 | 16 | 11 | 14 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](C(=O)NCC(N)=O)C(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 137650792 | 313337 | 0 | None | 97 | 2 | Human | 10.8 | pEC50 | = | 10.8 | Functional | ChEMBL | 991 | 18 | 11 | 14 | -2.4 | CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4078856 | 313337 | 0 | None | 97 | 2 | Human | 10.8 | pEC50 | = | 10.8 | Functional | ChEMBL | 991 | 18 | 11 | 14 | -2.4 | CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.bmcl.2017.04.030 | ||
| 137653639 | 314898 | 0 | None | 40 | 2 | Human | 10.7 | pEC50 | = | 10.7 | Functional | ChEMBL | 949 | 15 | 11 | 14 | -3.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4096848 | 314898 | 0 | None | 40 | 2 | Human | 10.7 | pEC50 | = | 10.7 | Functional | ChEMBL | 949 | 15 | 11 | 14 | -3.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 76073634 | 234791 | 7 | None | 3981 | 3 | Human | 10.6 | pEC50 | = | 10.6 | Functional | ChEMBL | 1041 | 20 | 11 | 13 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | ||
| CHEMBL3354594 | 234791 | 7 | None | 3981 | 3 | Human | 10.6 | pEC50 | = | 10.6 | Functional | ChEMBL | 1041 | 20 | 11 | 13 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | ||
| DB12932 | 234791 | 7 | None | 3981 | 3 | Human | 10.6 | pEC50 | = | 10.6 | Functional | ChEMBL | 1041 | 20 | 11 | 13 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | ||
| 137632034 | 312207 | 0 | None | 48 | 2 | Human | 10.6 | pEC50 | = | 10.6 | Functional | ChEMBL | 1019 | 20 | 11 | 14 | -1.6 | CCCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.bmcl.2017.04.030 | ||
| 137661047 | 312207 | 0 | None | 48 | 2 | Human | 10.6 | pEC50 | = | 10.6 | Functional | ChEMBL | 1019 | 20 | 11 | 14 | -1.6 | CCCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4065273 | 312207 | 0 | None | 48 | 2 | Human | 10.6 | pEC50 | = | 10.6 | Functional | ChEMBL | 1019 | 20 | 11 | 14 | -1.6 | CCCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4101771 | 312207 | 0 | None | 48 | 2 | Human | 10.6 | pEC50 | = | 10.6 | Functional | ChEMBL | 1019 | 20 | 11 | 14 | -1.6 | CCCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.bmcl.2017.04.030 | ||
| 155536940 | 336772 | 0 | None | 17 | 3 | Human | 10.6 | pEC50 | = | 10.6 | Functional | ChEMBL | 1074 | 20 | 12 | 15 | -2.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | ||
| CHEMBL4474284 | 336772 | 0 | None | 17 | 3 | Human | 10.6 | pEC50 | = | 10.6 | Functional | ChEMBL | 1074 | 20 | 12 | 15 | -2.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | ||
| 137652597 | 314676 | 0 | None | 2 | 2 | Human | 10.5 | pEC50 | = | 10.5 | Functional | ChEMBL | 1034 | 19 | 14 | 15 | -4.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4094454 | 314676 | 0 | None | 2 | 2 | Human | 10.5 | pEC50 | = | 10.5 | Functional | ChEMBL | 1034 | 19 | 14 | 15 | -4.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 137654217 | 314545 | 0 | None | None | None | Human | 10.5 | pEC50 | = | 10.5 | Functional | ChEMBL | 987 | 15 | 14 | 14 | -5.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCC(=O)NC[C@@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NNC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4092971 | 314545 | 0 | None | None | None | Human | 10.5 | pEC50 | = | 10.5 | Functional | ChEMBL | 987 | 15 | 14 | 14 | -5.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCC(=O)NC[C@@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NNC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 155565903 | 349729 | 0 | None | None | None | Human | 10.5 | pEC50 | = | 10.5 | Functional | ChEMBL | 1024 | 21 | 13 | 16 | -4.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | ||
| CHEMBL4583231 | 349729 | 0 | None | None | None | Human | 10.5 | pEC50 | = | 10.5 | Functional | ChEMBL | 1024 | 21 | 13 | 16 | -4.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | ||
| 2042 | 8014 | 41 | None | 1 | 5 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmcl.2017.12.027 | ||
| 2176 | 8014 | 41 | None | 1 | 5 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmcl.2017.12.027 | ||
| 439302 | 8014 | 41 | None | 1 | 5 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL395429 | 8014 | 41 | None | 1 | 5 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmcl.2017.12.027 | ||
| 449224 | 333602 | 12 | None | 54 | 4 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | 991 | 17 | 11 | 14 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL439044 | 333602 | 12 | None | 54 | 4 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | 991 | 17 | 11 | 14 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| DB13798 | 333602 | 12 | None | 54 | 4 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | 991 | 17 | 11 | 14 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| 2042 | 8014 | 41 | None | 1 | 5 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmc.2016.05.062 | ||
| 2176 | 8014 | 41 | None | 1 | 5 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmc.2016.05.062 | ||
| 439302 | 8014 | 41 | None | 1 | 5 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmc.2016.05.062 | ||
| CHEMBL395429 | 8014 | 41 | None | 1 | 5 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmc.2016.05.062 | ||
| 449224 | 333602 | 12 | None | 54 | 4 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | 991 | 17 | 11 | 14 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| CHEMBL439044 | 333602 | 12 | None | 54 | 4 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | 991 | 17 | 11 | 14 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| DB13798 | 333602 | 12 | None | 54 | 4 | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | 991 | 17 | 11 | 14 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| 137647351 | 313452 | 0 | None | None | None | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | 995 | 19 | 12 | 15 | -3.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(C)[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4080341 | 313452 | 0 | None | None | None | Human | 10.4 | pEC50 | = | 10.4 | Functional | ChEMBL | 995 | 19 | 12 | 15 | -3.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(C)[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 137648677 | 313850 | 0 | None | 44 | 2 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 1025 | 17 | 11 | 14 | -2.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4084795 | 313850 | 0 | None | 44 | 2 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 1025 | 17 | 11 | 14 | -2.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 137634607 | 312031 | 0 | None | 11 | 2 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 965 | 16 | 12 | 15 | -4.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CO)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4063150 | 312031 | 0 | None | 11 | 2 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 965 | 16 | 12 | 15 | -4.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CO)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 90680084 | 220999 | 0 | None | None | None | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 965 | 18 | 12 | 14 | -3.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL3277915 | 220999 | 0 | None | None | None | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 965 | 18 | 12 | 14 | -3.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 137661245 | 315315 | 0 | None | 123 | 2 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 950 | 15 | 11 | 14 | -2.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4101586 | 315315 | 0 | None | 123 | 2 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 950 | 15 | 11 | 14 | -2.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 90285421 | 233973 | 1 | None | -9 | 2 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 334 | 4 | 1 | 5 | 2.7 | O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(Cl)cc1 | 10.1016/j.ejmech.2017.05.013 | ||
| CHEMBL3342789 | 233973 | 1 | None | -9 | 2 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 334 | 4 | 1 | 5 | 2.7 | O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(Cl)cc1 | 10.1016/j.ejmech.2017.05.013 | ||
| 3601935 | 317856 | 1 | None | 1 | 2 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 271 | 3 | 1 | 4 | 1.9 | Cn1nccc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.ejmech.2017.05.013 | ||
| CHEMBL4165132 | 317856 | 1 | None | 1 | 2 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 271 | 3 | 1 | 4 | 1.9 | Cn1nccc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.ejmech.2017.05.013 | ||
| 137634089 | 312221 | 0 | None | None | None | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 981 | 19 | 13 | 15 | -4.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4065416 | 312221 | 0 | None | None | None | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 981 | 19 | 13 | 15 | -4.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 155527198 | 335719 | 0 | None | 8 | 3 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 1056 | 20 | 12 | 14 | -2.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | ||
| CHEMBL4458988 | 335719 | 0 | None | 8 | 3 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 1056 | 20 | 12 | 14 | -2.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | ||
| 146681949 | 8624 | 35 | None | -97 | 5 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/acs.jmedchem.8b01691 | ||
| 2168 | 8624 | 35 | None | -97 | 5 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/acs.jmedchem.8b01691 | ||
| 2810 | 8624 | 35 | None | -97 | 5 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/acs.jmedchem.8b01691 | ||
| 644077 | 8624 | 35 | None | -97 | 5 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/acs.jmedchem.8b01691 | ||
| CHEMBL373742 | 8624 | 35 | None | -97 | 5 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/acs.jmedchem.8b01691 | ||
| DB00067 | 8624 | 35 | None | -97 | 5 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/acs.jmedchem.8b01691 | ||
| P01185 | 8624 | 35 | None | -97 | 5 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/acs.jmedchem.8b01691 | ||
| P01186 | 8624 | 35 | None | -97 | 5 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/acs.jmedchem.8b01691 | ||
| P35455 | 8624 | 35 | None | -97 | 5 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/acs.jmedchem.8b01691 | ||
| 76685194 | 233974 | 1 | None | -5 | 2 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 368 | 4 | 1 | 5 | 3.1 | O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(C(F)(F)F)cc1 | 10.1016/j.ejmech.2017.05.013 | ||
| CHEMBL3342790 | 233974 | 1 | None | -5 | 2 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 368 | 4 | 1 | 5 | 3.1 | O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(C(F)(F)F)cc1 | 10.1016/j.ejmech.2017.05.013 | ||
| 5014150 | 327880 | 1 | None | 1 | 2 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 305 | 3 | 1 | 4 | 2.2 | Cn1nccc1NS(=O)(=O)c1ccc(C(F)(F)F)cc1 | 10.1016/j.ejmech.2017.05.013 | ||
| CHEMBL4173036 | 327880 | 1 | None | 1 | 2 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 305 | 3 | 1 | 4 | 2.2 | Cn1nccc1NS(=O)(=O)c1ccc(C(F)(F)F)cc1 | 10.1016/j.ejmech.2017.05.013 | ||
| 137631348 | 312356 | 0 | None | None | None | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 979 | 18 | 11 | 14 | -2.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(C)[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4066923 | 312356 | 0 | None | None | None | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 979 | 18 | 11 | 14 | -2.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(C)[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 137639236 | 312666 | 0 | None | 3 | 2 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 1025 | 17 | 11 | 14 | -2.3 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4070577 | 312666 | 0 | None | 3 | 2 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 1025 | 17 | 11 | 14 | -2.3 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.bmcl.2017.04.030 | ||
| 18779926 | 38349 | 37 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 34 | 0 | 0 | 0 | 0.1 | S | 10.1016/j.bmcl.2017.04.030 | ||
| 402 | 38349 | 37 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 34 | 0 | 0 | 0 | 0.1 | S | 10.1016/j.bmcl.2017.04.030 | ||
| 5162682 | 38349 | 37 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 34 | 0 | 0 | 0 | 0.1 | S | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL1200739 | 38349 | 37 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 34 | 0 | 0 | 0 | 0.1 | S | 10.1016/j.bmcl.2017.04.030 | ||
| DB03328 | 38349 | 37 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 34 | 0 | 0 | 0 | 0.1 | S | 10.1016/j.bmcl.2017.04.030 | ||
| 137649234 | 313046 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 1005 | 17 | 10 | 14 | -2.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4075102 | 313046 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 1005 | 17 | 10 | 14 | -2.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 137654919 | 314555 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 1041 | 20 | 12 | 14 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4093088 | 314555 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 1041 | 20 | 12 | 14 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 126705667 | 314843 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 970 | 17 | 12 | 13 | -4.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCC(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4096331 | 314843 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 970 | 17 | 12 | 13 | -4.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCC(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 178316717 | 467830 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 628 | 6 | 3 | 10 | 3.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1C[C@@H](n2cc(CO)nn2)C[C@H]1C(=S)N(C)C | 10.1021/acsmedchemlett.5c00190 | ||
| CHEMBL6199441 | 467830 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 628 | 6 | 3 | 10 | 3.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1C[C@@H](n2cc(CO)nn2)C[C@H]1C(=S)N(C)C | 10.1021/acsmedchemlett.5c00190 | ||
| 178316487 | 467835 | 0 | None | None | None | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 628 | 6 | 3 | 10 | 3.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1C[C@H](n2cc(CO)nn2)C[C@H]1C(=S)N(C)C | 10.1021/acsmedchemlett.5c00190 | ||
| CHEMBL6199678 | 467835 | 0 | None | None | None | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 628 | 6 | 3 | 10 | 3.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1C[C@H](n2cc(CO)nn2)C[C@H]1C(=S)N(C)C | 10.1021/acsmedchemlett.5c00190 | ||
| 155532160 | 336257 | 0 | None | None | None | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 1006 | 21 | 13 | 15 | -4.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CCSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | ||
| CHEMBL4467042 | 336257 | 0 | None | None | None | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 1006 | 21 | 13 | 15 | -4.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CCSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | ||
| 137648427 | 313733 | 0 | None | 20 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 991 | 17 | 11 | 14 | -2.5 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4083700 | 313733 | 0 | None | 20 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 991 | 17 | 11 | 14 | -2.5 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 137652984 | 314497 | 0 | None | None | None | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 975 | 17 | 10 | 13 | -2.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4092407 | 314497 | 0 | None | None | None | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 975 | 17 | 10 | 13 | -2.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 137659822 | 315227 | 0 | None | 288 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 934 | 14 | 10 | 13 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4100627 | 315227 | 0 | None | 288 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 934 | 14 | 10 | 13 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 137641012 | 312956 | 0 | None | None | None | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 1007 | 18 | 12 | 15 | -3.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4073891 | 312956 | 0 | None | None | None | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 1007 | 18 | 12 | 15 | -3.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 137639340 | 312817 | 0 | None | None | None | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 985 | 16 | 12 | 13 | -4.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCC(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4072207 | 312817 | 0 | None | None | None | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 985 | 16 | 12 | 13 | -4.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCC(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 178316493 | 467836 | 0 | None | None | None | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 710 | 7 | 4 | 11 | 2.4 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1C[C@H](n2cc(CC3NC(=O)NC3=O)nn2)C[C@H]1C(=S)N(C)C | 10.1021/acsmedchemlett.5c00190 | ||
| CHEMBL6199684 | 467836 | 0 | None | None | None | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 710 | 7 | 4 | 11 | 2.4 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1C[C@H](n2cc(CC3NC(=O)NC3=O)nn2)C[C@H]1C(=S)N(C)C | 10.1021/acsmedchemlett.5c00190 | ||
| 118720268 | 234776 | 0 | None | 151 | 3 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 991 | 21 | 12 | 14 | -3.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | ||
| CHEMBL3354579 | 234776 | 0 | None | 151 | 3 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 991 | 21 | 12 | 14 | -3.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | ||
| 127051498 | 277875 | 0 | None | None | None | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 1005 | 17 | 10 | 14 | -2.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| CHEMBL3813771 | 277875 | 0 | None | None | None | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 1005 | 17 | 10 | 14 | -2.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| 2042 | 8014 | 41 | None | 1 | 5 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmc.2018.03.019 | ||
| 2176 | 8014 | 41 | None | 1 | 5 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmc.2018.03.019 | ||
| 439302 | 8014 | 41 | None | 1 | 5 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmc.2018.03.019 | ||
| CHEMBL395429 | 8014 | 41 | None | 1 | 5 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmc.2018.03.019 | ||
| 178306441 | 467813 | 0 | None | None | None | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 630 | 6 | 2 | 9 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1C[C@H](n2cc(CF)nn2)C[C@H]1C(=S)N(C)C | 10.1021/acsmedchemlett.5c00190 | ||
| CHEMBL6198760 | 467813 | 0 | None | None | None | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 630 | 6 | 2 | 9 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1C[C@H](n2cc(CF)nn2)C[C@H]1C(=S)N(C)C | 10.1021/acsmedchemlett.5c00190 | ||
| 137654665 | 314485 | 0 | None | None | None | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 1023 | 21 | 13 | 15 | -3.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4092242 | 314485 | 0 | None | None | None | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 1023 | 21 | 13 | 15 | -3.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 177823009 | 467794 | 0 | None | None | None | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 669 | 7 | 4 | 9 | 4.8 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1C[C@H](OCc2cc(O)cc(O)c2)C[C@H]1C(=S)N(C)C | 10.1021/acsmedchemlett.5c00191 | ||
| CHEMBL6197983 | 467794 | 0 | None | None | None | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 669 | 7 | 4 | 9 | 4.8 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1C[C@H](OCc2cc(O)cc(O)c2)C[C@H]1C(=S)N(C)C | 10.1021/acsmedchemlett.5c00191 | ||
| 145964703 | 329009 | 0 | None | None | None | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 822 | 12 | 8 | 12 | -1.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2COC)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL4208981 | 329009 | 0 | None | None | None | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 822 | 12 | 8 | 12 | -1.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2COC)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL3814633 | 487604 | 0 | None | None | None | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1020 | 17 | 11 | 15 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| 145975112 | 328640 | 0 | None | None | None | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 778 | 10 | 8 | 11 | -1.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCCC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL4204637 | 328640 | 0 | None | None | None | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 778 | 10 | 8 | 11 | -1.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCCC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL3814744 | 487605 | 0 | None | None | None | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1020 | 17 | 11 | 15 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| 137659747 | 315100 | 0 | None | None | None | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1091 | 21 | 14 | 15 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4099102 | 315100 | 0 | None | None | None | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1091 | 21 | 14 | 15 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 171649264 | 467827 | 0 | None | None | None | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 674 | 9 | 2 | 10 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1C[C@H](n2cc(COCCF)nn2)C[C@H]1C(=S)N(C)C | 10.1021/acsmedchemlett.5c00190 | ||
| CHEMBL6199342 | 467827 | 0 | None | None | None | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 674 | 9 | 2 | 10 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1C[C@H](n2cc(COCCF)nn2)C[C@H]1C(=S)N(C)C | 10.1021/acsmedchemlett.5c00190 | ||
| 127049296 | 277954 | 0 | None | None | None | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 1019 | 17 | 9 | 14 | -1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| CHEMBL3815099 | 277954 | 0 | None | None | None | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 1019 | 17 | 9 | 14 | -1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| 145978563 | 328775 | 0 | None | None | None | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 860 | 11 | 8 | 14 | -0.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2c2nnc(C)o2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL4206141 | 328775 | 0 | None | None | None | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 860 | 11 | 8 | 14 | -0.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2c2nnc(C)o2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| 145966784 | 329388 | 0 | None | None | None | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 792 | 10 | 8 | 11 | -0.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@@H]2C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL4213896 | 329388 | 0 | None | None | None | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 792 | 10 | 8 | 11 | -0.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@@H]2C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| 2042 | 8014 | 41 | None | 1 | 5 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.8b00697 | ||
| 2176 | 8014 | 41 | None | 1 | 5 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.8b00697 | ||
| 439302 | 8014 | 41 | None | 1 | 5 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL395429 | 8014 | 41 | None | 1 | 5 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.8b00697 | ||
| 145966470 | 329271 | 0 | None | None | None | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 883 | 13 | 9 | 12 | 0.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2CNc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL4212399 | 329271 | 0 | None | None | None | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 883 | 13 | 9 | 12 | 0.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2CNc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| 137654009 | 314631 | 0 | None | 29 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 976 | 16 | 10 | 13 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4094019 | 314631 | 0 | None | 29 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 976 | 16 | 10 | 13 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 145974697 | 329601 | 0 | None | None | None | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 855 | 11 | 8 | 12 | 0.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2c2ccccn2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL4216826 | 329601 | 0 | None | None | None | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 855 | 11 | 8 | 12 | 0.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2c2ccccn2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL3813894 | 487597 | 0 | None | None | None | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 1020 | 17 | 11 | 15 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| 137635522 | 312061 | 0 | None | 7 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1019 | 18 | 13 | 14 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4063521 | 312061 | 0 | None | 7 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1019 | 18 | 13 | 14 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 145976821 | 328632 | 0 | None | None | None | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 821 | 11 | 9 | 12 | -2.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL4204502 | 328632 | 0 | None | None | None | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 821 | 11 | 9 | 12 | -2.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| 137643372 | 313987 | 0 | None | None | None | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1005 | 17 | 11 | 14 | -2.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4086714 | 313987 | 0 | None | None | None | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1005 | 17 | 11 | 14 | -2.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 137638040 | 312672 | 0 | None | None | None | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 1050 | 22 | 15 | 15 | -3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4070617 | 312672 | 0 | None | None | None | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 1050 | 22 | 15 | 15 | -3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 137635922 | 311896 | 0 | None | None | None | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 1047 | 19 | 11 | 14 | -1.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4061446 | 311896 | 0 | None | None | None | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 1047 | 19 | 11 | 14 | -1.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 137647481 | 313695 | 0 | None | None | None | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 1081 | 19 | 11 | 14 | -0.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4083280 | 313695 | 0 | None | None | None | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 1081 | 19 | 11 | 14 | -0.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccccc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 145978698 | 328581 | 0 | None | None | None | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 905 | 14 | 8 | 12 | -0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N(C)CCC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL4203673 | 328581 | 0 | None | None | None | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 905 | 14 | 8 | 12 | -0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N(C)CCC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| 145977344 | 328692 | 0 | None | None | None | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 934 | 15 | 10 | 13 | -1.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL4205163 | 328692 | 0 | None | None | None | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 934 | 15 | 10 | 13 | -1.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| 178316031 | 467828 | 0 | None | None | None | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 694 | 8 | 3 | 12 | 2.9 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1C[C@H](n2cc(CCc3nnn[nH]3)nn2)C[C@H]1C(=S)N(C)C | 10.1021/acsmedchemlett.5c00190 | ||
| CHEMBL6199354 | 467828 | 0 | None | None | None | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 694 | 8 | 3 | 12 | 2.9 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1C[C@H](n2cc(CCc3nnn[nH]3)nn2)C[C@H]1C(=S)N(C)C | 10.1021/acsmedchemlett.5c00190 | ||
| 11169 | 1650 | 39 | None | 1 | 5 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b00697 | ||
| 165708555 | 1650 | 39 | None | 1 | 5 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b00697 | ||
| 16681432 | 1650 | 39 | None | 1 | 5 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b00697 | ||
| 495 | 1650 | 39 | None | 1 | 5 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL3301668 | 1650 | 39 | None | 1 | 5 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b00697 | ||
| DB01282 | 1650 | 39 | None | 1 | 5 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b00697 | ||
| 178315391 | 467833 | 0 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 549 | 4 | 2 | 6 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1C[C@H](F)C[C@H]1C(=S)N(C)C | 10.1021/acsmedchemlett.5c00191 | ||
| CHEMBL6199566 | 467833 | 0 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 549 | 4 | 2 | 6 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1C[C@H](F)C[C@H]1C(=S)N(C)C | 10.1021/acsmedchemlett.5c00191 | ||
| CHEMBL3814120 | 487598 | 0 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 1034 | 17 | 10 | 15 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N(C)CC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| 2042 | 8014 | 41 | None | 1 | 5 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm1016208 | ||
| 2176 | 8014 | 41 | None | 1 | 5 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm1016208 | ||
| 439302 | 8014 | 41 | None | 1 | 5 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm1016208 | ||
| CHEMBL395429 | 8014 | 41 | None | 1 | 5 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm1016208 | ||
| CHEMBL1817752 | 484896 | 0 | None | -77 | 4 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 1019 | 19 | 12 | 15 | -4.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm200278m | ||
| CHEMBL1819550 | 484929 | 0 | None | -47 | 4 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 967 | 17 | 12 | 16 | -5.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| CHEMBL1819550 | 484929 | 0 | None | -47 | 4 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 967 | 17 | 12 | 16 | -5.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| 145960494 | 317101 | 0 | None | 20 | 3 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 1081 | 17 | 11 | 14 | -0.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2ccc(cc2)SC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2018.03.019 | ||
| CHEMBL4128839 | 317101 | 0 | None | 20 | 3 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 1081 | 17 | 11 | 14 | -0.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2ccc(cc2)SC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2018.03.019 | ||
| CHEMBL1817761 | 484905 | 0 | None | -338 | 5 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 1039 | 20 | 12 | 16 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| CHEMBL1817752 | 484896 | 0 | None | -77 | 4 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 1019 | 19 | 12 | 15 | -4.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm200278m | ||
| CHEMBL1817761 | 484905 | 0 | None | -338 | 5 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 1039 | 20 | 12 | 16 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| 11454 | 7271 | 15 | None | -93 | 5 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 1047 | 21 | 12 | 15 | -3.2 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCNC(C)C)C | 10.1021/jm200278m | ||
| 53330936 | 7271 | 15 | None | -93 | 5 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 1047 | 21 | 12 | 15 | -3.2 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCNC(C)C)C | 10.1021/jm200278m | ||
| CHEMBL1817709 | 7271 | 15 | None | -93 | 5 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 1047 | 21 | 12 | 15 | -3.2 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCNC(C)C)C | 10.1021/jm200278m | ||
| DB12495 | 7271 | 15 | None | -93 | 5 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 1047 | 21 | 12 | 15 | -3.2 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCNC(C)C)C | 10.1021/jm200278m | ||
| 5329098 | 19472 | 58 | None | 1 | 2 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 238 | 1 | 2 | 1 | 3.1 | Cc1cc(C)c(/C=C2/C(=O)Nc3ccccc32)[nH]1 | nan | ||
| 5800609 | 19472 | 58 | None | 1 | 2 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 238 | 1 | 2 | 1 | 3.1 | Cc1cc(C)c(/C=C2/C(=O)Nc3ccccc32)[nH]1 | nan | ||
| CHEMBL105739 | 19472 | 58 | None | 1 | 2 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 238 | 1 | 2 | 1 | 3.1 | Cc1cc(C)c(/C=C2/C(=O)Nc3ccccc32)[nH]1 | nan | ||
| CHEMBL276711 | 19472 | 58 | None | 1 | 2 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 238 | 1 | 2 | 1 | 3.1 | Cc1cc(C)c(/C=C2/C(=O)Nc3ccccc32)[nH]1 | nan | ||
| DB06436 | 19472 | 58 | None | 1 | 2 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 238 | 1 | 2 | 1 | 3.1 | Cc1cc(C)c(/C=C2/C(=O)Nc3ccccc32)[nH]1 | nan | ||
| 137658241 | 315445 | 0 | None | None | None | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 964 | 16 | 11 | 14 | -2.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4103260 | 315445 | 0 | None | None | None | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 964 | 16 | 11 | 14 | -2.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL1819547 | 484926 | 0 | None | -63 | 4 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 984 | 17 | 12 | 17 | -5.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cscn2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| CHEMBL1819547 | 484926 | 0 | None | -63 | 4 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 984 | 17 | 12 | 17 | -5.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cscn2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| 90672737 | 219994 | 0 | None | None | None | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 970 | 17 | 12 | 13 | -4.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCNC(=O)C[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL3246917 | 219994 | 0 | None | None | None | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 970 | 17 | 12 | 13 | -4.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCNC(=O)C[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 172444756 | 389349 | 0 | None | None | None | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 1146 | 21 | 13 | 17 | -0.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)NCc2ccc(/N=N\c3ccc(C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)cc3)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.3c01415 | ||
| CHEMBL5437397 | 389349 | 0 | None | None | None | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 1146 | 21 | 13 | 17 | -0.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)NCc2ccc(/N=N\c3ccc(C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)cc3)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.3c01415 | ||
| 172455058 | 388068 | 0 | None | None | None | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 1160 | 22 | 13 | 17 | -0.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(/N=N/c3ccccc3)cc2)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.3c01415 | ||
| CHEMBL5409527 | 388068 | 0 | None | None | None | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 1160 | 22 | 13 | 17 | -0.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(/N=N/c3ccccc3)cc2)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.3c01415 | ||
| CHEMBL5424615 | 388068 | 0 | None | None | None | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 1160 | 22 | 13 | 17 | -0.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(/N=N/c3ccccc3)cc2)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.3c01415 | ||
| CHEMBL3814126 | 487599 | 0 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 1020 | 17 | 11 | 15 | -3.3 | CC[C@H](C)[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1016/j.bmc.2016.05.062 | ||
| 1112934 | 118908 | 7 | None | 1 | 2 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 425 | 5 | 1 | 5 | 4.7 | N=c1n(CC(=O)c2ccc(Br)s2)c2ccccc2n1Cc1ccccc1 | nan | ||
| CHEMBL1625302 | 118908 | 7 | None | 1 | 2 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 425 | 5 | 1 | 5 | 4.7 | N=c1n(CC(=O)c2ccc(Br)s2)c2ccccc2n1Cc1ccccc1 | nan | ||
| 146681949 | 8624 | 35 | None | -97 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm200278m | ||
| 2168 | 8624 | 35 | None | -97 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm200278m | ||
| 2810 | 8624 | 35 | None | -97 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm200278m | ||
| 644077 | 8624 | 35 | None | -97 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm200278m | ||
| CHEMBL373742 | 8624 | 35 | None | -97 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm200278m | ||
| DB00067 | 8624 | 35 | None | -97 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm200278m | ||
| P01185 | 8624 | 35 | None | -97 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm200278m | ||
| P01186 | 8624 | 35 | None | -97 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm200278m | ||
| P35455 | 8624 | 35 | None | -97 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm200278m | ||
| 146681949 | 8624 | 35 | None | -97 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm200278m | ||
| 2168 | 8624 | 35 | None | -97 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm200278m | ||
| 2810 | 8624 | 35 | None | -97 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm200278m | ||
| 644077 | 8624 | 35 | None | -97 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm200278m | ||
| CHEMBL373742 | 8624 | 35 | None | -97 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm200278m | ||
| DB00067 | 8624 | 35 | None | -97 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm200278m | ||
| P01185 | 8624 | 35 | None | -97 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm200278m | ||
| P01186 | 8624 | 35 | None | -97 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm200278m | ||
| P35455 | 8624 | 35 | None | -97 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm200278m | ||
| CHEMBL1817705 | 484891 | 0 | None | -61 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 1005 | 19 | 12 | 15 | -4.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| CHEMBL3813858 | 487595 | 0 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 1034 | 17 | 10 | 15 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC(C)C)C(=O)NCC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| 135506374 | 275287 | 21 | None | -2 | 3 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL3763342 | 275287 | 21 | None | -2 | 3 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.8b00697 | ||
| 25161471 | 117879 | 13 | None | -1 | 2 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 265 | 4 | 2 | 2 | 3.5 | Oc1ccc(Cl)cc1CNCc1ccc(F)cc1 | nan | ||
| CHEMBL1616435 | 117879 | 13 | None | -1 | 2 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 265 | 4 | 2 | 2 | 3.5 | Oc1ccc(Cl)cc1CNCc1ccc(F)cc1 | nan | ||
| 118716666 | 233980 | 0 | None | None | None | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 437 | 4 | 1 | 6 | 3.5 | O=S(=O)(Nc1ccnn1-c1ncc(C(F)(F)F)cn1)c1ccc(C(F)(F)F)cc1 | 10.1021/ml5004348 | ||
| CHEMBL3342796 | 233980 | 0 | None | None | None | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 437 | 4 | 1 | 6 | 3.5 | O=S(=O)(Nc1ccnn1-c1ncc(C(F)(F)F)cn1)c1ccc(C(F)(F)F)cc1 | 10.1021/ml5004348 | ||
| 90286664 | 233982 | 0 | None | None | None | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 375 | 6 | 1 | 7 | 3.0 | CCc1ccc(S(=O)(=O)Nc2ccnn2-c2nc(C3CC3)ns2)cc1 | 10.1021/ml5004348 | ||
| CHEMBL3342798 | 233982 | 0 | None | None | None | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 375 | 6 | 1 | 7 | 3.0 | CCc1ccc(S(=O)(=O)Nc2ccnn2-c2nc(C3CC3)ns2)cc1 | 10.1021/ml5004348 | ||
| CHEMBL1817705 | 484891 | 0 | None | -61 | 5 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 1005 | 19 | 12 | 15 | -4.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| 2369069 | 353177 | 3 | None | -1 | 2 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 346 | 3 | 0 | 5 | 4.0 | CCN1C(=S)SC(=O)C1=C1C=C(C)N(Cc2ccco2)C(C)=C1 | nan | ||
| CHEMBL473106 | 353177 | 3 | None | -1 | 2 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 346 | 3 | 0 | 5 | 4.0 | CCN1C(=S)SC(=O)C1=C1C=C(C)N(Cc2ccco2)C(C)=C1 | nan | ||
| 137658004 | 315510 | 0 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 948 | 15 | 10 | 13 | -1.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4104022 | 315510 | 0 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 948 | 15 | 10 | 13 | -1.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 90286007 | 233978 | 0 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 382 | 4 | 1 | 5 | 3.4 | Cc1ccnc(-n2nccc2NS(=O)(=O)c2ccc(C(F)(F)F)cc2)c1 | 10.1021/ml5004348 | ||
| CHEMBL3342794 | 233978 | 0 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 382 | 4 | 1 | 5 | 3.4 | Cc1ccnc(-n2nccc2NS(=O)(=O)c2ccc(C(F)(F)F)cc2)c1 | 10.1021/ml5004348 | ||
| 53363016 | 137115 | 0 | None | -28 | 4 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 1005 | 18 | 12 | 15 | -4.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)NC)NC1=O | 10.1021/jm200278m | ||
| CHEMBL1819557 | 137115 | 0 | None | -28 | 4 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 1005 | 18 | 12 | 15 | -4.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)NC)NC1=O | 10.1021/jm200278m | ||
| CHEMBL3814232 | 487601 | 0 | None | None | None | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 1034 | 18 | 11 | 15 | -3.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| 10444 | 4740 | 20 | None | 2 | 3 | Mouse | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 531 | 4 | 2 | 6 | 4.2 | Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C | 10.1021/acs.jmedchem.8b00697 | ||
| 145711714 | 4740 | 20 | None | 2 | 3 | Mouse | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 531 | 4 | 2 | 6 | 4.2 | Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL4204210 | 4740 | 20 | None | 2 | 3 | Mouse | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 531 | 4 | 2 | 6 | 4.2 | Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL1819556 | 484934 | 0 | None | -190 | 4 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 927 | 15 | 12 | 15 | -5.7 | CC[C@H](C)[C@@H]1NC(=O)C2(CCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| 2919564 | 63850 | 16 | None | -1 | 2 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | 404 | 9 | 2 | 5 | 4.0 | COc1ccc(CCNCC(O)Cn2c3ccccc3c3ccccc32)cc1OC | nan | ||
| CHEMBL1390471 | 63850 | 16 | None | -1 | 2 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | 404 | 9 | 2 | 5 | 4.0 | COc1ccc(CCNCC(O)Cn2c3ccccc3c3ccccc32)cc1OC | nan | ||
| 90285421 | 233973 | 1 | None | -9 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 334 | 4 | 1 | 5 | 2.7 | O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(Cl)cc1 | 10.1016/j.ejmech.2017.05.013 | ||
| CHEMBL3342789 | 233973 | 1 | None | -9 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 334 | 4 | 1 | 5 | 2.7 | O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(Cl)cc1 | 10.1016/j.ejmech.2017.05.013 | ||
| 90285421 | 233973 | 1 | None | -9 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 334 | 4 | 1 | 5 | 2.7 | O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(Cl)cc1 | 10.1021/ml5004348 | ||
| CHEMBL3342789 | 233973 | 1 | None | -9 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 334 | 4 | 1 | 5 | 2.7 | O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(Cl)cc1 | 10.1021/ml5004348 | ||
| 90285984 | 233977 | 6 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 352 | 4 | 1 | 5 | 2.9 | O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(Cl)cc1F | 10.1021/ml5004348 | ||
| CHEMBL3342793 | 233977 | 6 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 352 | 4 | 1 | 5 | 2.9 | O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(Cl)cc1F | 10.1021/ml5004348 | ||
| 145974945 | 329641 | 0 | None | None | None | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 884 | 13 | 8 | 12 | 0.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2COc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL4217353 | 329641 | 0 | None | None | None | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 884 | 13 | 8 | 12 | 0.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2COc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| 42601352 | 78877 | 0 | None | -1 | 2 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | 282 | 4 | 2 | 3 | 3.4 | Oc1ccc(Cl)cc1CNCc1ccc(Cl)nc1 | nan | ||
| CHEMBL1437791 | 78877 | 0 | None | -1 | 2 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | 282 | 4 | 2 | 3 | 3.4 | Oc1ccc(Cl)cc1CNCc1ccc(Cl)nc1 | nan | ||
| 2042 | 8014 | 41 | None | -1 | 5 | Mouse | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.8b00697 | ||
| 2176 | 8014 | 41 | None | -1 | 5 | Mouse | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.8b00697 | ||
| 439302 | 8014 | 41 | None | -1 | 5 | Mouse | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL395429 | 8014 | 41 | None | -1 | 5 | Mouse | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.8b00697 | ||
| 11454 | 7271 | 15 | None | -93 | 5 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1047 | 21 | 12 | 15 | -3.2 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCNC(C)C)C | 10.1021/jm200278m | ||
| 53330936 | 7271 | 15 | None | -93 | 5 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1047 | 21 | 12 | 15 | -3.2 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCNC(C)C)C | 10.1021/jm200278m | ||
| CHEMBL1817709 | 7271 | 15 | None | -93 | 5 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1047 | 21 | 12 | 15 | -3.2 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCNC(C)C)C | 10.1021/jm200278m | ||
| DB12495 | 7271 | 15 | None | -93 | 5 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1047 | 21 | 12 | 15 | -3.2 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCNC(C)C)C | 10.1021/jm200278m | ||
| 127049997 | 277867 | 0 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1019 | 17 | 9 | 14 | -1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N(C)CC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| CHEMBL3813707 | 277867 | 0 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1019 | 17 | 9 | 14 | -1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N(C)CC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| 2042 | 8014 | 41 | None | 1 | 5 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.3c01415 | ||
| 2176 | 8014 | 41 | None | 1 | 5 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.3c01415 | ||
| 439302 | 8014 | 41 | None | 1 | 5 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.3c01415 | ||
| CHEMBL395429 | 8014 | 41 | None | 1 | 5 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.3c01415 | ||
| 155555127 | 348389 | 0 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 1485 | 46 | 11 | 17 | 7.5 | CCCCCCCCCCCCCCCC(=O)N[C@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(OC(=O)OCCCCCCCCCCCCCC)cc2)NC1=O | 10.1016/j.bmc.2019.06.018 | ||
| CHEMBL4550879 | 348389 | 0 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 1485 | 46 | 11 | 17 | 7.5 | CCCCCCCCCCCCCCCC(=O)N[C@H]1CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(OC(=O)OCCCCCCCCCCCCCC)cc2)NC1=O | 10.1016/j.bmc.2019.06.018 | ||
| 6174589 | 217219 | 5 | None | -1 | 2 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | 379 | 6 | 2 | 6 | 2.0 | CCN(CC)c1ccc2cc(C(N)=O)/c(=N\NC(=O)c3ccncc3)oc2c1 | nan | ||
| CHEMBL3189462 | 217219 | 5 | None | -1 | 2 | Human | 4.7 | pEC50 | = | 4.7 | Functional | ChEMBL | 379 | 6 | 2 | 6 | 2.0 | CCN(CC)c1ccc2cc(C(N)=O)/c(=N\NC(=O)c3ccncc3)oc2c1 | nan | ||
| 137651797 | 313029 | 0 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 1010 | 16 | 10 | 13 | -0.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4074898 | 313029 | 0 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 1010 | 16 | 10 | 13 | -0.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL3814165 | 487600 | 0 | None | None | None | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 1020 | 17 | 11 | 15 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| 135506374 | 275287 | 21 | None | -2 | 3 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL3763342 | 275287 | 21 | None | -2 | 3 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.8b00697 | ||
| 90285817 | 233975 | 0 | None | None | None | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 351 | 4 | 1 | 4 | 3.5 | O=S(=O)(Nc1ccnn1-c1ccc(F)cc1)c1ccc(Cl)cc1 | 10.1021/ml5004348 | ||
| CHEMBL3342791 | 233975 | 0 | None | None | None | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 351 | 4 | 1 | 4 | 3.5 | O=S(=O)(Nc1ccnn1-c1ccc(F)cc1)c1ccc(Cl)cc1 | 10.1021/ml5004348 | ||
| 10444 | 4740 | 20 | None | -2 | 3 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 531 | 4 | 2 | 6 | 4.2 | Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C | 10.1021/acs.jmedchem.8b00697 | ||
| 145711714 | 4740 | 20 | None | -2 | 3 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 531 | 4 | 2 | 6 | 4.2 | Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL4204210 | 4740 | 20 | None | -2 | 3 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 531 | 4 | 2 | 6 | 4.2 | Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL3814617 | 487603 | 0 | None | None | None | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 1020 | 17 | 11 | 15 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)N(C)C(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| CHEMBL1817756 | 484900 | 0 | None | -426 | 5 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 1023 | 20 | 12 | 16 | -4.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| 2042 | 8014 | 41 | None | 1 | 5 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.8b00697 | ||
| 2176 | 8014 | 41 | None | 1 | 5 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.8b00697 | ||
| 439302 | 8014 | 41 | None | 1 | 5 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL395429 | 8014 | 41 | None | 1 | 5 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL1817756 | 484900 | 0 | None | -426 | 5 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 1023 | 20 | 12 | 16 | -4.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| 172444756 | 387375 | 0 | None | None | None | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 1146 | 21 | 13 | 17 | -0.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)NCc2ccc(/N=N/c3ccc(C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)cc3)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.3c01415 | ||
| CHEMBL5395020 | 387375 | 0 | None | None | None | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 1146 | 21 | 13 | 17 | -0.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)NCc2ccc(/N=N/c3ccc(C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)cc3)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.3c01415 | ||
| 23983726 | 102093 | 5 | None | -1 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 472 | 1 | 3 | 3 | 6.2 | CC1(C)CC[C@@]2(C(=O)O)C(C1)C1=CCC3[C@@]4(C)CC[C@H](O)C(C)(C)C4CC[C@@]3(C)[C@]1(C)C[C@H]2O | nan | ||
| CHEMBL1559201 | 102093 | 5 | None | -1 | 2 | Human | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 472 | 1 | 3 | 3 | 6.2 | CC1(C)CC[C@@]2(C(=O)O)C(C1)C1=CCC3[C@@]4(C)CC[C@H](O)C(C)(C)C4CC[C@@]3(C)[C@]1(C)C[C@H]2O | nan | ||
| 3650228 | 118800 | 6 | None | -1 | 2 | Human | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | 402 | 5 | 2 | 3 | 5.1 | COc1ccc(C2NCCc3c2[nH]c2ccccc32)cc1COc1ccc(F)cc1 | nan | ||
| CHEMBL1624349 | 118800 | 6 | None | -1 | 2 | Human | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | 402 | 5 | 2 | 3 | 5.1 | COc1ccc(C2NCCc3c2[nH]c2ccccc32)cc1COc1ccc(F)cc1 | nan | ||
| 921775 | 85438 | 5 | None | None | None | Human | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | 304 | 4 | 2 | 4 | 3.7 | COc1ccc(CNc2[nH]cnc3c4ccccc4nc2-3)cc1 | nan | ||
| CHEMBL1495292 | 85438 | 5 | None | None | None | Human | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | 304 | 4 | 2 | 4 | 3.7 | COc1ccc(CNc2[nH]cnc3c4ccccc4nc2-3)cc1 | nan | ||
| 145973088 | 329627 | 0 | None | None | None | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 681 | 9 | 8 | 10 | -1.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL4217226 | 329627 | 0 | None | None | None | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 681 | 9 | 8 | 10 | -1.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| 135413563 | 241495 | 20 | None | 28 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 600 | 4 | 2 | 7 | 4.3 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1 | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL360648 | 241495 | 20 | None | 28 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 600 | 4 | 2 | 7 | 4.3 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1 | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL3813879 | 487596 | 0 | None | None | None | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 1034 | 17 | 10 | 15 | -2.9 | CC[C@H](C)[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1016/j.bmc.2016.05.062 | ||
| CHEMBL1819548 | 484927 | 0 | None | -53 | 4 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 983 | 17 | 12 | 16 | -5.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| 135506374 | 275287 | 21 | None | 2 | 3 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.7b00965 | ||
| CHEMBL3763342 | 275287 | 21 | None | 2 | 3 | Mouse | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.7b00965 | ||
| CHEMBL1819548 | 484927 | 0 | None | -53 | 4 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 983 | 17 | 12 | 16 | -5.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| CHEMBL1819549 | 484928 | 0 | None | -47 | 4 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 983 | 17 | 12 | 16 | -5.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccsc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| 145963213 | 317022 | 0 | None | 28 | 3 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 1095 | 17 | 11 | 14 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2ccccc2CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2018.03.019 | ||
| CHEMBL4127791 | 317022 | 0 | None | 28 | 3 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 1095 | 17 | 11 | 14 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2ccccc2CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2018.03.019 | ||
| 135506374 | 275287 | 21 | None | -2 | 3 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL3763342 | 275287 | 21 | None | -2 | 3 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.8b00697 | ||
| 2042 | 8014 | 41 | None | 1 | 5 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.ejmech.2015.11.050 | ||
| 2176 | 8014 | 41 | None | 1 | 5 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.ejmech.2015.11.050 | ||
| 439302 | 8014 | 41 | None | 1 | 5 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.ejmech.2015.11.050 | ||
| CHEMBL395429 | 8014 | 41 | None | 1 | 5 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.ejmech.2015.11.050 | ||
| CHEMBL1819541 | 484920 | 0 | None | -14 | 4 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 1007 | 18 | 13 | 16 | -4.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| CHEMBL1819541 | 484920 | 0 | None | -14 | 4 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 1007 | 18 | 13 | 16 | -4.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| 137640630 | 312970 | 0 | None | None | None | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 1007 | 20 | 12 | 14 | -2.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4074033 | 312970 | 0 | None | None | None | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 1007 | 20 | 12 | 14 | -2.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 137656718 | 315393 | 0 | None | None | None | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 941 | 17 | 10 | 13 | -2.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4102595 | 315393 | 0 | None | None | None | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 941 | 17 | 10 | 13 | -2.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 145975622 | 328722 | 0 | None | None | None | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 918 | 11 | 8 | 13 | -1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N2CCCN(C)CC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL4205509 | 328722 | 0 | None | None | None | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 918 | 11 | 8 | 13 | -1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N2CCCN(C)CC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL1819549 | 484928 | 0 | None | -47 | 4 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 983 | 17 | 12 | 16 | -5.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccsc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| 172442093 | 387543 | 0 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 1033 | 17 | 12 | 16 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)NCc2ccc(/N=N\c3ccc(C(=O)NCC(N)=O)cc3)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.3c01415 | ||
| CHEMBL5398356 | 387543 | 0 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 1033 | 17 | 12 | 16 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)NCc2ccc(/N=N\c3ccc(C(=O)NCC(N)=O)cc3)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.3c01415 | ||
| 145972114 | 329557 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 515 | 4 | 2 | 6 | 3.4 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=O)N(C)C | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL4216174 | 329557 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 515 | 4 | 2 | 6 | 3.4 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=O)N(C)C | 10.1021/acs.jmedchem.8b00697 | ||
| 178293085 | 467792 | 0 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 591 | 7 | 3 | 8 | 3.2 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1C[C@H](OCCO)C[C@H]1C(=S)N(C)C | 10.1021/acsmedchemlett.5c00191 | ||
| CHEMBL6197957 | 467792 | 0 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 591 | 7 | 3 | 8 | 3.2 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1C[C@H](OCCO)C[C@H]1C(=S)N(C)C | 10.1021/acsmedchemlett.5c00191 | ||
| CHEMBL1817707 | 484893 | 0 | None | -194 | 5 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 1019 | 20 | 12 | 15 | -4.0 | CCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm200278m | ||
| CHEMBL1817706 | 484892 | 0 | None | -309 | 5 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 1033 | 21 | 12 | 15 | -3.6 | CCCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm200278m | ||
| CHEMBL1817707 | 484893 | 0 | None | -194 | 5 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 1019 | 20 | 12 | 15 | -4.0 | CCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm200278m | ||
| CHEMBL1817706 | 484892 | 0 | None | -309 | 5 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 1033 | 21 | 12 | 15 | -3.6 | CCCNCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm200278m | ||
| CHEMBL1817704 | 484890 | 0 | None | -257 | 5 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 1033 | 20 | 12 | 15 | -3.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| 135413563 | 241495 | 20 | None | 28 | 2 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 600 | 4 | 2 | 7 | 4.3 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1 | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL360648 | 241495 | 20 | None | 28 | 2 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 600 | 4 | 2 | 7 | 4.3 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1 | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL1817704 | 484890 | 0 | None | -257 | 5 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 1033 | 20 | 12 | 15 | -3.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| 145962220 | 317117 | 0 | None | 87 | 3 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 1095 | 17 | 11 | 14 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2cccc(c2)CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2018.03.019 | ||
| CHEMBL4129142 | 317117 | 0 | None | 87 | 3 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 1095 | 17 | 11 | 14 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2cccc(c2)CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2018.03.019 | ||
| 172455058 | 388068 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 1160 | 22 | 13 | 17 | -0.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(/N=N/c3ccccc3)cc2)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.3c01415 | ||
| CHEMBL5409527 | 388068 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 1160 | 22 | 13 | 17 | -0.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(/N=N/c3ccccc3)cc2)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.3c01415 | ||
| CHEMBL5424615 | 388068 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 1160 | 22 | 13 | 17 | -0.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N[C@@H](Cc2ccc(/N=N/c3ccccc3)cc2)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.3c01415 | ||
| 172449652 | 388133 | 0 | None | None | None | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 1094 | 19 | 11 | 16 | -0.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(/N=N/c3ccccc3)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.3c01415 | ||
| CHEMBL5410810 | 388133 | 0 | None | None | None | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 1094 | 19 | 11 | 16 | -0.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(/N=N/c3ccccc3)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.3c01415 | ||
| CHEMBL5412177 | 388133 | 0 | None | None | None | Human | 5.5 | pEC50 | = | 5.5 | Functional | ChEMBL | 1094 | 19 | 11 | 16 | -0.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(/N=N/c3ccccc3)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.3c01415 | ||
| 127049996 | 277885 | 0 | None | None | None | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 1019 | 17 | 9 | 14 | -1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC(C)C)C(=O)NCC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| CHEMBL3813883 | 277885 | 0 | None | None | None | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 1019 | 17 | 9 | 14 | -1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC(C)C)C(=O)NCC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| 137637782 | 311929 | 0 | None | None | None | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 949 | 15 | 11 | 14 | -3.6 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4061946 | 311929 | 0 | None | None | None | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 949 | 15 | 11 | 14 | -3.6 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL3814395 | 487602 | 0 | None | None | None | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 1020 | 18 | 12 | 15 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| 137654636 | 314406 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 965 | 16 | 12 | 15 | -4.6 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4091483 | 314406 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 965 | 16 | 12 | 15 | -4.6 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.bmcl.2017.04.030 | ||
| 11169 | 1650 | 39 | None | 1 | 5 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b00697 | ||
| 165708555 | 1650 | 39 | None | 1 | 5 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b00697 | ||
| 16681432 | 1650 | 39 | None | 1 | 5 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b00697 | ||
| 495 | 1650 | 39 | None | 1 | 5 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL3301668 | 1650 | 39 | None | 1 | 5 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b00697 | ||
| DB01282 | 1650 | 39 | None | 1 | 5 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b00697 | ||
| 135506374 | 275287 | 21 | None | -2 | 3 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1016/j.ejmech.2017.10.059 | ||
| CHEMBL3763342 | 275287 | 21 | None | -2 | 3 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1016/j.ejmech.2017.10.059 | ||
| 135506374 | 275287 | 21 | None | -2 | 3 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1016/j.ejmech.2015.11.050 | ||
| CHEMBL3763342 | 275287 | 21 | None | -2 | 3 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1016/j.ejmech.2015.11.050 | ||
| CHEMBL1817708 | 484894 | 0 | None | -53 | 4 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 1062 | 22 | 12 | 15 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNCCC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| CHEMBL1817708 | 484894 | 0 | None | -53 | 4 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 1062 | 22 | 12 | 15 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNCCC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| 10444 | 4740 | 20 | None | -2 | 3 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 531 | 4 | 2 | 6 | 4.2 | Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C | 10.1021/acsmedchemlett.5c00191 | ||
| 145711714 | 4740 | 20 | None | -2 | 3 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 531 | 4 | 2 | 6 | 4.2 | Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C | 10.1021/acsmedchemlett.5c00191 | ||
| CHEMBL4204210 | 4740 | 20 | None | -2 | 3 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 531 | 4 | 2 | 6 | 4.2 | Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C | 10.1021/acsmedchemlett.5c00191 | ||
| 172449652 | 388133 | 0 | None | None | None | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 1094 | 19 | 11 | 16 | -0.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(/N=N/c3ccccc3)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.3c01415 | ||
| CHEMBL5410810 | 388133 | 0 | None | None | None | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 1094 | 19 | 11 | 16 | -0.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(/N=N/c3ccccc3)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.3c01415 | ||
| CHEMBL5412177 | 388133 | 0 | None | None | None | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 1094 | 19 | 11 | 16 | -0.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(/N=N/c3ccccc3)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.3c01415 | ||
| 90285722 | 233979 | 0 | None | None | None | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 400 | 5 | 1 | 6 | 3.7 | O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(SC(F)(F)F)cc1 | 10.1021/ml5004348 | ||
| CHEMBL3342795 | 233979 | 0 | None | None | None | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 400 | 5 | 1 | 6 | 3.7 | O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(SC(F)(F)F)cc1 | 10.1021/ml5004348 | ||
| 2042 | 8014 | 41 | None | 1 | 5 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | ||
| 2176 | 8014 | 41 | None | 1 | 5 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | ||
| 439302 | 8014 | 41 | None | 1 | 5 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | ||
| CHEMBL395429 | 8014 | 41 | None | 1 | 5 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | ||
| 137648249 | 313872 | 0 | None | None | None | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 992 | 17 | 11 | 14 | -1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4085152 | 313872 | 0 | None | None | None | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 992 | 17 | 11 | 14 | -1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 145975847 | 328690 | 0 | None | None | None | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 882 | 13 | 8 | 11 | 1.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2CCc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL4205128 | 328690 | 0 | None | None | None | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 882 | 13 | 8 | 11 | 1.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2CCc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| 145977939 | 328909 | 0 | None | None | None | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 724 | 10 | 9 | 11 | -2.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL4207691 | 328909 | 0 | None | None | None | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 724 | 10 | 9 | 11 | -2.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL3813722 | 487593 | 0 | None | None | None | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 1034 | 17 | 10 | 15 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| 90285477 | 233976 | 0 | None | None | None | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 388 | 4 | 1 | 6 | 3.5 | Cc1csc(-n2nccc2NS(=O)(=O)c2ccc(C(F)(F)F)cc2)n1 | 10.1021/ml5004348 | ||
| CHEMBL3342792 | 233976 | 0 | None | None | None | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 388 | 4 | 1 | 6 | 3.5 | Cc1csc(-n2nccc2NS(=O)(=O)c2ccc(C(F)(F)F)cc2)n1 | 10.1021/ml5004348 | ||
| 10444 | 4740 | 20 | None | -2 | 3 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 531 | 4 | 2 | 6 | 4.2 | Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C | 10.1021/acs.jmedchem.8b00697 | ||
| 145711714 | 4740 | 20 | None | -2 | 3 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 531 | 4 | 2 | 6 | 4.2 | Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL4204210 | 4740 | 20 | None | -2 | 3 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 531 | 4 | 2 | 6 | 4.2 | Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C | 10.1021/acs.jmedchem.8b00697 | ||
| 145964151 | 329254 | 0 | None | None | None | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 958 | 12 | 8 | 13 | -0.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N2CCC(N3CCCC3)CC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL4212247 | 329254 | 0 | None | None | None | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 958 | 12 | 8 | 13 | -0.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N2CCC(N3CCCC3)CC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.12.027 | ||
| CHEMBL3813729 | 487594 | 0 | None | None | None | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 1034 | 17 | 10 | 15 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| 135506374 | 275287 | 21 | None | -2 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1016/j.ejmech.2015.11.050 | ||
| CHEMBL3763342 | 275287 | 21 | None | -2 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1016/j.ejmech.2015.11.050 | ||
| 135506374 | 275287 | 21 | None | -2 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL3763342 | 275287 | 21 | None | -2 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.8b00697 | ||
| 135506374 | 275287 | 21 | None | -2 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.7b00965 | ||
| CHEMBL3763342 | 275287 | 21 | None | -2 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.7b00965 | ||
| 10444 | 4740 | 20 | None | -2 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 531 | 4 | 2 | 6 | 4.2 | Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C | 10.1021/acs.jmedchem.8b00697 | ||
| 145711714 | 4740 | 20 | None | -2 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 531 | 4 | 2 | 6 | 4.2 | Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL4204210 | 4740 | 20 | None | -2 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 531 | 4 | 2 | 6 | 4.2 | Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C | 10.1021/acs.jmedchem.8b00697 | ||
| 11169 | 1650 | 39 | None | -10 | 5 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b00697 | ||
| 165708555 | 1650 | 39 | None | -10 | 5 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b00697 | ||
| 16681432 | 1650 | 39 | None | -10 | 5 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b00697 | ||
| 495 | 1650 | 39 | None | -10 | 5 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL3301668 | 1650 | 39 | None | -10 | 5 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b00697 | ||
| DB01282 | 1650 | 39 | None | -10 | 5 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b00697 | ||
| 127051499 | 277888 | 0 | None | None | None | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 1019 | 17 | 9 | 14 | -1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| CHEMBL3813982 | 277888 | 0 | None | None | None | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 1019 | 17 | 9 | 14 | -1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | ||
| CHEMBL1819440 | 484917 | 24 | None | -204 | 5 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 1041 | 18 | 13 | 16 | -4.7 | NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm200278m | ||
| DB13464 | 484917 | 24 | None | -204 | 5 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 1041 | 18 | 13 | 16 | -4.7 | NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm200278m | ||
| CHEMBL1819440 | 484917 | 24 | None | -204 | 5 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 1041 | 18 | 13 | 16 | -4.7 | NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm200278m | ||
| DB13464 | 484917 | 24 | None | -204 | 5 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 1041 | 18 | 13 | 16 | -4.7 | NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm200278m | ||
| 90285806 | 233981 | 0 | None | None | None | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 432 | 5 | 1 | 7 | 2.4 | O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(S(=O)(=O)C(F)(F)F)cc1 | 10.1021/ml5004348 | ||
| CHEMBL3342797 | 233981 | 0 | None | None | None | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 432 | 5 | 1 | 7 | 2.4 | O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(S(=O)(=O)C(F)(F)F)cc1 | 10.1021/ml5004348 | ||
| CHEMBL1817759 | 484903 | 0 | None | -53 | 3 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 953 | 16 | 12 | 16 | -5.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm200278m | ||
| 135506374 | 275287 | 21 | None | 2 | 3 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL3763342 | 275287 | 21 | None | 2 | 3 | Mouse | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL1817759 | 484903 | 0 | None | -53 | 3 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 953 | 16 | 12 | 16 | -5.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm200278m | ||
| 2042 | 8014 | 41 | None | 1 | 5 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | ||
| 2176 | 8014 | 41 | None | 1 | 5 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | ||
| 439302 | 8014 | 41 | None | 1 | 5 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | ||
| CHEMBL395429 | 8014 | 41 | None | 1 | 5 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | ||
| 76685194 | 233974 | 1 | None | -5 | 2 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 368 | 4 | 1 | 5 | 3.1 | O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(C(F)(F)F)cc1 | 10.1016/j.ejmech.2017.05.013 | ||
| CHEMBL3342790 | 233974 | 1 | None | -5 | 2 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 368 | 4 | 1 | 5 | 3.1 | O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(C(F)(F)F)cc1 | 10.1016/j.ejmech.2017.05.013 | ||
| 76685194 | 233974 | 1 | None | -5 | 2 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 368 | 4 | 1 | 5 | 3.1 | O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(C(F)(F)F)cc1 | 10.1021/ml5004348 | ||
| CHEMBL3342790 | 233974 | 1 | None | -5 | 2 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 368 | 4 | 1 | 5 | 3.1 | O=S(=O)(Nc1ccnn1-c1ccccn1)c1ccc(C(F)(F)F)cc1 | 10.1021/ml5004348 | ||
| 146681949 | 8624 | 35 | None | -97 | 5 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm1016208 | ||
| 2168 | 8624 | 35 | None | -97 | 5 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm1016208 | ||
| 2810 | 8624 | 35 | None | -97 | 5 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm1016208 | ||
| 644077 | 8624 | 35 | None | -97 | 5 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm1016208 | ||
| CHEMBL373742 | 8624 | 35 | None | -97 | 5 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm1016208 | ||
| DB00067 | 8624 | 35 | None | -97 | 5 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm1016208 | ||
| P01185 | 8624 | 35 | None | -97 | 5 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm1016208 | ||
| P01186 | 8624 | 35 | None | -97 | 5 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm1016208 | ||
| P35455 | 8624 | 35 | None | -97 | 5 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm1016208 | ||
| CHEMBL1817763 | 484907 | 0 | None | -63 | 3 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 1025 | 19 | 12 | 16 | -3.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm200278m | ||
| CHEMBL1817763 | 484907 | 0 | None | -63 | 3 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 1025 | 19 | 12 | 16 | -3.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm200278m | ||
| 135506374 | 275287 | 21 | None | -2 | 3 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL3763342 | 275287 | 21 | None | -2 | 3 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.8b00697 | ||
| 137652261 | 313042 | 0 | None | None | None | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 1006 | 18 | 11 | 14 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4075079 | 313042 | 0 | None | None | None | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 1006 | 18 | 11 | 14 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL1819543 | 484922 | 0 | None | -18 | 4 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 977 | 17 | 12 | 15 | -5.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| CHEMBL1819543 | 484922 | 0 | None | -18 | 4 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 977 | 17 | 12 | 15 | -5.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm200278m | ||
| 137653770 | 314630 | 0 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 1063 | 20 | 12 | 15 | -2.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| CHEMBL4094014 | 314630 | 0 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 1063 | 20 | 12 | 15 | -2.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmcl.2017.04.030 | ||
| 172442093 | 387966 | 0 | None | None | None | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 1033 | 17 | 12 | 16 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)NCc2ccc(/N=N/c3ccc(C(=O)NCC(N)=O)cc3)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.3c01415 | ||
| CHEMBL5407278 | 387966 | 0 | None | None | None | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 1033 | 17 | 12 | 16 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)NCc2ccc(/N=N/c3ccc(C(=O)NCC(N)=O)cc3)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.3c01415 | ||
| CHEMBL1817758 | 484902 | 0 | None | -63 | 3 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 1009 | 19 | 12 | 16 | -4.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm200278m | ||
| CHEMBL1817758 | 484902 | 0 | None | -63 | 3 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 1009 | 19 | 12 | 16 | -4.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccco2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm200278m | ||
| 90663156 | 216271 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 1377 | 36 | 13 | 17 | 0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)CC1(SCCC(N)=O)CCCCC1)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc1ccc(N=[N+]=[N-])c(I)c1)C(N)=O)[C@@H](C)O | 10.1021/jm010125u | ||
| CHEMBL3142790 | 216271 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 1377 | 36 | 13 | 17 | 0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)CC1(SCCC(N)=O)CCCCC1)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc1ccc(N=[N+]=[N-])c(I)c1)C(N)=O)[C@@H](C)O | 10.1021/jm010125u | ||
| 44459839 | 200024 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 573 | 12 | 3 | 7 | 2.3 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@@H](Cc2cccs2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00201-3 | ||
| CHEMBL285608 | 200024 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 573 | 12 | 3 | 7 | 2.3 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@@H](Cc2cccs2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00201-3 | ||
| 155520603 | 335054 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 431 | 6 | 0 | 7 | 4.0 | COCc1nnc(N2CCC(c3ccc(F)cc3Cl)CC2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4449435 | 335054 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 431 | 6 | 0 | 7 | 4.0 | COCc1nnc(N2CCC(c3ccc(F)cc3Cl)CC2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| 10411308 | 462175 | 0 | None | -190 | 3 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 446 | 4 | 1 | 2 | 6.6 | O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1-c1ccccc1 | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL603708 | 462175 | 0 | None | -190 | 3 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 446 | 4 | 1 | 2 | 6.6 | O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1-c1ccccc1 | 10.1021/acs.jmedchem.8b00697 | ||
| 2213 | 1072 | 37 | None | 12 | 2 | Rat | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2005.10.107 | ||
| 3008 | 1072 | 37 | None | 12 | 2 | Rat | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2005.10.107 | ||
| 5311010 | 1072 | 37 | None | 12 | 2 | Rat | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2005.10.107 | ||
| 68613 | 1072 | 37 | None | 12 | 2 | Rat | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2005.10.107 | ||
| CHEMBL378642 | 1072 | 37 | None | 12 | 2 | Rat | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2005.10.107 | ||
| CHEMBL382301 | 1072 | 37 | None | 12 | 2 | Rat | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2005.10.107 | ||
| DB09059 | 1072 | 37 | None | 12 | 2 | Rat | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2005.10.107 | ||
| 155517601 | 334746 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 444 | 6 | 0 | 8 | 2.9 | COCc1nnc(N2CC3CN(c4ccc(F)cc4Cl)C3C2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4444840 | 334746 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 444 | 6 | 0 | 8 | 2.9 | COCc1nnc(N2CC3CN(c4ccc(F)cc4Cl)C3C2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| 155516256 | 334599 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 473 | 7 | 0 | 8 | 4.2 | COCc1nnc(N2C3CCC2CC(Oc2ccc(F)cc2Cl)C3)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4442843 | 334599 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 473 | 7 | 0 | 8 | 4.2 | COCc1nnc(N2C3CCC2CC(Oc2ccc(F)cc2Cl)C3)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| 9824954 | 155543 | 0 | None | -2 | 3 | Rat | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 449 | 2 | 1 | 5 | 5.5 | Cc1ccn(-c2ccc(C(=O)N3Cc4cccnc4Nc4ccccc43)c(C(F)(F)F)c2)n1 | 10.1016/j.bmcl.2005.10.107 | ||
| CHEMBL201889 | 155543 | 0 | None | -2 | 3 | Rat | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 449 | 2 | 1 | 5 | 5.5 | Cc1ccn(-c2ccc(C(=O)N3Cc4cccnc4Nc4ccccc43)c(C(F)(F)F)c2)n1 | 10.1016/j.bmcl.2005.10.107 | ||
| 44458614 | 199317 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 571 | 7 | 2 | 5 | 3.7 | C[C@@H](O)CN1CCC[C@@H](C(=O)NC2CC3CCC2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1 | 10.1021/jm970342o | ||
| CHEMBL280678 | 199317 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 571 | 7 | 2 | 5 | 3.7 | C[C@@H](O)CN1CCC[C@@H](C(=O)NC2CC3CCC2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1 | 10.1021/jm970342o | ||
| 142391767 | 334212 | 0 | None | 6 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 442 | 5 | 0 | 7 | 3.7 | COCc1nnc(N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)n1-c1ccc2c(c1)OCO2 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4437214 | 334212 | 0 | None | 6 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 442 | 5 | 0 | 7 | 3.7 | COCc1nnc(N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)n1-c1ccc2c(c1)OCO2 | 10.1021/acsmedchemlett.9b00186 | ||
| 155542139 | 347192 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 473 | 7 | 0 | 8 | 3.9 | COCc1nnc(N2C[C@H]3C[C@@H](Oc4ccc(F)cc4Cl)C[C@H]3C2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4519861 | 347192 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 473 | 7 | 0 | 8 | 3.9 | COCc1nnc(N2C[C@H]3C[C@@H](Oc4ccc(F)cc4Cl)C[C@H]3C2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| 135413562 | 4496 | 12 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 624 | 14 | 3 | 7 | 1.1 | CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C | 10.1021/jm050645f | ||
| 2194 | 4496 | 12 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 624 | 14 | 3 | 7 | 1.1 | CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C | 10.1021/jm050645f | ||
| CHEMBL445816 | 4496 | 12 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 624 | 14 | 3 | 7 | 1.1 | CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C | 10.1021/jm050645f | ||
| 135493119 | 160559 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 569 | 11 | 2 | 7 | 3.3 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | ||
| CHEMBL2113201 | 160559 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 569 | 11 | 2 | 7 | 3.3 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | ||
| 135192983 | 346716 | 24 | None | 190 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 429 | 6 | 0 | 7 | 3.4 | COCc1nnc(N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4591825 | 346716 | 24 | None | 190 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 429 | 6 | 0 | 7 | 3.4 | COCc1nnc(N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| 135399831 | 160552 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 597 | 11 | 2 | 8 | 2.7 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)NC(=O)c3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | ||
| CHEMBL2113189 | 160552 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 597 | 11 | 2 | 8 | 2.7 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)NC(=O)c3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | ||
| 145961670 | 316908 | 0 | None | -123 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 1139 | 19 | 14 | 15 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2ccccc2CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2018.03.019 | ||
| CHEMBL4126100 | 316908 | 0 | None | -123 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 1139 | 19 | 14 | 15 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2ccccc2CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2018.03.019 | ||
| 135192979 | 349818 | 0 | None | 41 | 4 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 485 | 7 | 0 | 8 | 3.5 | COc1ccc(-n2c(CO[C@H]3CCOC3)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4585239 | 349818 | 0 | None | 41 | 4 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 485 | 7 | 0 | 8 | 3.5 | COc1ccc(-n2c(CO[C@H]3CCOC3)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 | 10.1021/acsmedchemlett.9b00186 | ||
| 135192895 | 348054 | 0 | None | 8 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 485 | 7 | 0 | 8 | 3.5 | COc1ccc(-n2c(CO[C@@H]3CCOC3)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4542267 | 348054 | 0 | None | 8 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 485 | 7 | 0 | 8 | 3.5 | COc1ccc(-n2c(CO[C@@H]3CCOC3)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 | 10.1021/acsmedchemlett.9b00186 | ||
| 135192936 | 346622 | 1 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 429 | 6 | 0 | 7 | 3.4 | COCc1nnc(N2CC3CC3(c3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4518063 | 346622 | 1 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 429 | 6 | 0 | 7 | 3.4 | COCc1nnc(N2CC3CC3(c3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| 11683187 | 444222 | 42 | None | 20 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 419 | 7 | 0 | 8 | 2.9 | COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL594828 | 444222 | 42 | None | 20 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 419 | 7 | 0 | 8 | 2.9 | COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| 135193003 | 349387 | 0 | None | 3 | 3 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 424 | 5 | 0 | 7 | 3.3 | COc1ccc(-n2c(CC#N)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4575160 | 349387 | 0 | None | 3 | 3 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 424 | 5 | 0 | 7 | 3.3 | COc1ccc(-n2c(CC#N)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 | 10.1021/acsmedchemlett.9b00186 | ||
| 155558305 | 348779 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 459 | 6 | 0 | 8 | 3.0 | COCc1nnc(N2CC3COCC3(c3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4560499 | 348779 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 459 | 6 | 0 | 8 | 3.0 | COCc1nnc(N2CC3COCC3(c3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| 146238444 | 336202 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 417 | 6 | 0 | 7 | 3.6 | COCc1nnc(N2CCC(c3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4466263 | 336202 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 417 | 6 | 0 | 7 | 3.6 | COCc1nnc(N2CCC(c3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| 155554422 | 348644 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 445 | 7 | 0 | 7 | 4.0 | COCc1nnc(C2CCN(Cc3ccc(F)cc3Cl)CC2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4557241 | 348644 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 445 | 7 | 0 | 7 | 4.0 | COCc1nnc(C2CCN(Cc3ccc(F)cc3Cl)CC2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| 11465834 | 275790 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 483 | 6 | 1 | 3 | 3.3 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(F)cc1F | 10.1021/jm060073e | ||
| CHEMBL377414 | 275790 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 483 | 6 | 1 | 3 | 3.3 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(F)cc1F | 10.1021/jm060073e | ||
| 135192928 | 348934 | 0 | None | 125 | 4 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 429 | 6 | 0 | 7 | 3.4 | COCc1nnc(N2C[C@@H]3C[C@]3(c3cccc(F)c3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4564411 | 348934 | 0 | None | 125 | 4 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 429 | 6 | 0 | 7 | 3.4 | COCc1nnc(N2C[C@@H]3C[C@]3(c3cccc(F)c3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| 1103817 | 40884 | 7 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 492 | 8 | 2 | 6 | 3.1 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(C)cc2)cc1 | 10.1021/jm050645f | ||
| CHEMBL1254117 | 40884 | 7 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 492 | 8 | 2 | 6 | 3.1 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(C)cc2)cc1 | 10.1021/jm050645f | ||
| 135530014 | 160549 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 526 | 9 | 3 | 6 | 2.9 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(CCCO)cc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm050645f | ||
| CHEMBL2113179 | 160549 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 526 | 9 | 3 | 6 | 2.9 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(CCCO)cc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm050645f | ||
| 145976595 | 328683 | 0 | None | -2 | 3 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 408 | 2 | 1 | 4 | 4.9 | Cc1ccn(C(=O)Nc2ccc(C(=O)N3CCCCc4ccccc43)c(Cl)c2)n1 | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL4205046 | 328683 | 0 | None | -2 | 3 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 408 | 2 | 1 | 4 | 4.9 | Cc1ccn(C(=O)Nc2ccc(C(=O)N3CCCCc4ccccc43)c(Cl)c2)n1 | 10.1021/acs.jmedchem.8b00697 | ||
| 2213 | 1072 | 37 | None | -12 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.ejmech.2017.05.013 | ||
| 3008 | 1072 | 37 | None | -12 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.ejmech.2017.05.013 | ||
| 5311010 | 1072 | 37 | None | -12 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.ejmech.2017.05.013 | ||
| 68613 | 1072 | 37 | None | -12 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.ejmech.2017.05.013 | ||
| CHEMBL378642 | 1072 | 37 | None | -12 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.ejmech.2017.05.013 | ||
| CHEMBL382301 | 1072 | 37 | None | -12 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.ejmech.2017.05.013 | ||
| DB09059 | 1072 | 37 | None | -12 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.ejmech.2017.05.013 | ||
| 155564470 | 349427 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 411 | 5 | 0 | 8 | 2.5 | COCc1nnc(N2CC3(CCc4cc(F)ccc4O3)C2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4576147 | 349427 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 411 | 5 | 0 | 8 | 2.5 | COCc1nnc(N2CC3(CCc4cc(F)ccc4O3)C2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| 137212772 | 275327 | 0 | None | -3 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 609 | 7 | 2 | 8 | 4.7 | COc1cc(CN2CCN(C(=O)NCc3ccc(C(=O)N4Cc5cnn(C)c5Nc5ccccc54)cc3C)CC2)cc(OC)c1 | 10.1016/j.ejmech.2017.10.059 | ||
| CHEMBL3763951 | 275327 | 0 | None | -3 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 609 | 7 | 2 | 8 | 4.7 | COc1cc(CN2CCN(C(=O)NCc3ccc(C(=O)N4Cc5cnn(C)c5Nc5ccccc54)cc3C)CC2)cc(OC)c1 | 10.1016/j.ejmech.2017.10.059 | ||
| 137212772 | 275327 | 0 | None | -3 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 609 | 7 | 2 | 8 | 4.7 | COc1cc(CN2CCN(C(=O)NCc3ccc(C(=O)N4Cc5cnn(C)c5Nc5ccccc54)cc3C)CC2)cc(OC)c1 | 10.1016/j.ejmech.2015.11.050 | ||
| CHEMBL3763951 | 275327 | 0 | None | -3 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 609 | 7 | 2 | 8 | 4.7 | COc1cc(CN2CCN(C(=O)NCc3ccc(C(=O)N4Cc5cnn(C)c5Nc5ccccc54)cc3C)CC2)cc(OC)c1 | 10.1016/j.ejmech.2015.11.050 | ||
| 135192889 | 348116 | 0 | None | 25 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 425 | 5 | 0 | 6 | 4.1 | COc1ccc(-n2c(C3CC3)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4543809 | 348116 | 0 | None | 25 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 425 | 5 | 0 | 6 | 4.1 | COc1ccc(-n2c(C3CC3)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 | 10.1021/acsmedchemlett.9b00186 | ||
| 135192997 | 347907 | 0 | None | 18 | 4 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 461 | 8 | 0 | 7 | 3.7 | COc1ccc(-n2c(COCCF)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4538696 | 347907 | 0 | None | 18 | 4 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 461 | 8 | 0 | 7 | 3.7 | COc1ccc(-n2c(COCCF)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 | 10.1021/acsmedchemlett.9b00186 | ||
| 135508167 | 160548 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 596 | 10 | 3 | 8 | 2.8 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(NCCN2CCOCC2)cc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm050645f | ||
| CHEMBL2113177 | 160548 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 596 | 10 | 3 | 8 | 2.8 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(NCCN2CCOCC2)cc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm050645f | ||
| 44459838 | 199816 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 635 | 12 | 3 | 6 | 3.6 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00201-3 | ||
| CHEMBL284120 | 199816 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 635 | 12 | 3 | 6 | 3.6 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00201-3 | ||
| 142391805 | 348045 | 0 | None | 35 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 435 | 5 | 0 | 6 | 4.2 | COc1ccc(-n2c(C(F)F)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4541860 | 348045 | 0 | None | 35 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 435 | 5 | 0 | 6 | 4.2 | COc1ccc(-n2c(C(F)F)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 | 10.1021/acsmedchemlett.9b00186 | ||
| 145952624 | 317877 | 0 | None | -1 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 889 | 21 | 2 | 10 | 3.3 | CC[C@H](C)[C@@H](OC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC | 10.1021/acs.jmedchem.8b00885 | ||
| CHEMBL4165525 | 317877 | 0 | None | -1 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 889 | 21 | 2 | 10 | 3.3 | CC[C@H](C)[C@@H](OC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC | 10.1021/acs.jmedchem.8b00885 | ||
| 3537 | 8682 | 25 | None | 1 | 4 | Rat | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 402 | 2 | 0 | 4 | 4.8 | Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 | 10.1021/acs.jmedchem.8b00697 | ||
| 5311500 | 8682 | 25 | None | 1 | 4 | Rat | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 402 | 2 | 0 | 4 | 4.8 | Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL363910 | 8682 | 25 | None | 1 | 4 | Rat | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 402 | 2 | 0 | 4 | 4.8 | Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 | 10.1021/acs.jmedchem.8b00697 | ||
| 145957924 | 317591 | 0 | None | -2 | 3 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 886 | 20 | 2 | 10 | 3.4 | CC[C@H](C)[C@@H](OC(=O)/C=C\c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC | 10.1021/acs.jmedchem.8b00885 | ||
| CHEMBL4161021 | 317591 | 0 | None | -2 | 3 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 886 | 20 | 2 | 10 | 3.4 | CC[C@H](C)[C@@H](OC(=O)/C=C\c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC | 10.1021/acs.jmedchem.8b00885 | ||
| 2213 | 1072 | 37 | None | -12 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm050645f | ||
| 3008 | 1072 | 37 | None | -12 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm050645f | ||
| 5311010 | 1072 | 37 | None | -12 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm050645f | ||
| 68613 | 1072 | 37 | None | -12 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm050645f | ||
| CHEMBL378642 | 1072 | 37 | None | -12 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm050645f | ||
| CHEMBL382301 | 1072 | 37 | None | -12 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm050645f | ||
| DB09059 | 1072 | 37 | None | -12 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm050645f | ||
| 135469700 | 160561 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 555 | 10 | 2 | 7 | 2.9 | CN(C)CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | ||
| CHEMBL2113203 | 160561 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 555 | 10 | 2 | 7 | 2.9 | CN(C)CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | ||
| 145974527 | 329683 | 0 | None | -67 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 491 | 5 | 3 | 6 | 3.3 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)NCC(=S)N(C)C | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL4217872 | 329683 | 0 | None | -67 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 491 | 5 | 3 | 6 | 3.3 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)NCC(=S)N(C)C | 10.1021/acs.jmedchem.8b00697 | ||
| 11683187 | 444222 | 42 | None | 20 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 419 | 7 | 0 | 8 | 2.9 | COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL594828 | 444222 | 42 | None | 20 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 419 | 7 | 0 | 8 | 2.9 | COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/acs.jmedchem.8b00697 | ||
| 135192930 | 335321 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 429 | 6 | 0 | 7 | 3.4 | COCc1nnc(N2C[C@H]3C[C@@]3(c3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4452863 | 335321 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 429 | 6 | 0 | 7 | 3.4 | COCc1nnc(N2C[C@H]3C[C@@]3(c3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| 11683187 | 444222 | 42 | None | 20 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 419 | 7 | 0 | 8 | 2.9 | COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL594828 | 444222 | 42 | None | 20 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 419 | 7 | 0 | 8 | 2.9 | COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/acs.jmedchem.8b00697 | ||
| 2252 | 4546 | 39 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/s0960-894x(02)00160-9 | ||
| 6918320 | 4546 | 39 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/s0960-894x(02)00160-9 | ||
| CHEMBL24781 | 4546 | 39 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/s0960-894x(02)00160-9 | ||
| 155537980 | 336855 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 397 | 5 | 0 | 8 | 2.2 | COCc1nnc(N2CC3(C2)OCc2cc(F)ccc23)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4475530 | 336855 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 397 | 5 | 0 | 8 | 2.2 | COCc1nnc(N2CC3(C2)OCc2cc(F)ccc23)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| 145953024 | 318077 | 0 | None | -15 | 4 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 886 | 20 | 2 | 10 | 3.4 | CC[C@H](C)[C@@H](OC(=O)/C=C/c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC | 10.1021/acs.jmedchem.8b00885 | ||
| CHEMBL4168948 | 318077 | 0 | None | -15 | 4 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 886 | 20 | 2 | 10 | 3.4 | CC[C@H](C)[C@@H](OC(=O)/C=C/c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC | 10.1021/acs.jmedchem.8b00885 | ||
| 9871105 | 198920 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 513 | 5 | 2 | 4 | 3.6 | CC1(C)C2CCC1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C(NC(=O)C1CCCNC1)C2 | 10.1021/jm970342o | ||
| CHEMBL277400 | 198920 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 513 | 5 | 2 | 4 | 3.6 | CC1(C)C2CCC1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C(NC(=O)C1CCCNC1)C2 | 10.1021/jm970342o | ||
| 135476004 | 160551 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 597 | 10 | 2 | 8 | 2.7 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(OCCN2CCOCC2)cc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm050645f | ||
| CHEMBL2113185 | 160551 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 597 | 10 | 2 | 8 | 2.7 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(OCCN2CCOCC2)cc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm050645f | ||
| 135414531 | 160566 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 586 | 13 | 2 | 8 | 3.1 | COCCOCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | ||
| CHEMBL2113208 | 160566 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 586 | 13 | 2 | 8 | 3.1 | COCCOCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | ||
| 145970269 | 328552 | 0 | None | -15 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 475 | 5 | 3 | 6 | 2.5 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)NCC(=O)N(C)C | 10.1021/acs.jmedchem.8b00697 | ||
| CHEMBL4203314 | 328552 | 0 | None | -15 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 475 | 5 | 3 | 6 | 2.5 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)NCC(=O)N(C)C | 10.1021/acs.jmedchem.8b00697 | ||
| 135469685 | 160569 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 542 | 10 | 2 | 7 | 3.0 | COCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | ||
| CHEMBL2113211 | 160569 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 542 | 10 | 2 | 7 | 3.0 | COCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | ||
| 135192948 | 349608 | 0 | None | 5 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 499 | 7 | 0 | 8 | 3.9 | COc1ccc(-n2c(COC3CCOCC3)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4580413 | 349608 | 0 | None | 5 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 499 | 7 | 0 | 8 | 3.9 | COc1ccc(-n2c(COC3CCOCC3)nnc2N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)cn1 | 10.1021/acsmedchemlett.9b00186 | ||
| 135530164 | 160558 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 570 | 11 | 2 | 8 | 2.7 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccncc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | ||
| CHEMBL2113200 | 160558 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 570 | 11 | 2 | 8 | 2.7 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccncc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | ||
| 155568614 | 350093 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 444 | 6 | 0 | 8 | 2.9 | COCc1nnc(N2CC3CN(c4ccc(F)cc4Cl)CC32)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4591943 | 350093 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 444 | 6 | 0 | 8 | 2.9 | COCc1nnc(N2CC3CN(c4ccc(F)cc4Cl)CC32)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| 11634973 | 157006 | 17 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 518 | 6 | 1 | 5 | 2.8 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1ccc(C)nc1C | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL2037511 | 157006 | 17 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 518 | 6 | 1 | 5 | 2.8 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1ccc(C)nc1C | 10.1021/acsmedchemlett.9b00186 | ||
| DB11934 | 157006 | 17 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 518 | 6 | 1 | 5 | 2.8 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1ccc(C)nc1C | 10.1021/acsmedchemlett.9b00186 | ||
| 135192932 | 336061 | 0 | None | 190 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 443 | 7 | 0 | 7 | 3.8 | CCOCc1nnc(N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4464246 | 336061 | 0 | None | 190 | 4 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 443 | 7 | 0 | 7 | 3.8 | CCOCc1nnc(N2C[C@@H]3C[C@]3(c3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| 155565553 | 349600 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 446 | 7 | 0 | 8 | 2.9 | COCc1nnc(N2CCN(Cc3ccc(F)cc3Cl)CC2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| CHEMBL4580192 | 349600 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 446 | 7 | 0 | 8 | 2.9 | COCc1nnc(N2CCN(Cc3ccc(F)cc3Cl)CC2)n1-c1ccc(OC)nc1 | 10.1021/acsmedchemlett.9b00186 | ||
| 14981575 | 160372 | 0 | None | None | None | Rat | 9.0 | pKd | = | 9 | Functional | ChEMBL | 582 | 10 | 1 | 7 | 2.1 | Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)N(C)C)C3(C)C)CC1 | 10.1021/jm00031a004 | ||
| CHEMBL2112896 | 160372 | 0 | None | None | None | Rat | 9.0 | pKd | = | 9 | Functional | ChEMBL | 582 | 10 | 1 | 7 | 2.1 | Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)N(C)C)C3(C)C)CC1 | 10.1021/jm00031a004 | ||
| 10437668 | 155157 | 1 | None | None | None | Rat | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 554 | 9 | 2 | 7 | 1.5 | Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@@H](N)CCS(C)(=O)=O)C3(C)C)CC1 | 10.1021/jm00031a004 | ||
| CHEMBL2112903 | 155157 | 1 | None | None | None | Rat | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 554 | 9 | 2 | 7 | 1.5 | Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@@H](N)CCS(C)(=O)=O)C3(C)C)CC1 | 10.1021/jm00031a004 | ||
| CHEMBL1790200 | 484796 | 0 | None | None | None | Rat | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 1032 | 9 | 12 | 15 | -3.1 | CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](N)C(C)(C)SSC[C@@H]2NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(=O)NCCCC[C@H](C(=O)NCC(N)=O)NC(=O)[C@H]3CCCN3C2=O)NC1=O | 10.1021/jm00087a009 | ||
| 16737617 | 197207 | 0 | None | None | None | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 1053 | 17 | 11 | 14 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | ||
| 16737618 | 197207 | 0 | None | None | None | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 1053 | 17 | 11 | 14 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL265630 | 197207 | 0 | None | None | None | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 1053 | 17 | 11 | 14 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL415418 | 197207 | 0 | None | None | None | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 1053 | 17 | 11 | 14 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL539918 | 489217 | 0 | None | None | None | Rat | 7.0 | pKd | = | 7 | Functional | ChEMBL | 1114 | 18 | 13 | 14 | -1.9 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(c2ccccc2)c2ccccc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1016/j.ejmech.2008.12.010 | ||
| CHEMBL435159 | 488611 | 0 | None | None | None | Rat | 7.0 | pKd | = | 7 | Functional | ChEMBL | 1068 | 17 | 12 | 15 | -2.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL261938 | 486037 | 0 | None | None | None | Rat | 7.0 | pKd | = | 7 | Functional | ChEMBL | 1159 | 20 | 14 | 16 | -3.8 | NC(=O)CC[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(c2ccccc2)c2ccccc2)NC(=O)[C@H](N)CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm058038f | ||
| 44429299 | 333850 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 1035 | 20 | 11 | 14 | -1.3 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL441128 | 333850 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 1035 | 20 | 11 | 14 | -1.3 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| 44429298 | 294154 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 1033 | 19 | 10 | 14 | -1.5 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3CCCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL393020 | 294154 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 1033 | 19 | 10 | 14 | -1.5 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3CCCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| 16736614 | 295716 | 0 | None | None | None | Rat | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 975 | 16 | 10 | 13 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H]2Cc3ccccc3CN2C(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL394268 | 295716 | 0 | None | None | None | Rat | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 975 | 16 | 10 | 13 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H]2Cc3ccccc3CN2C(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | ||
| 44429304 | 178138 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 1062 | 19 | 10 | 14 | -0.7 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)N3CCCC[C@@H]3C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL233080 | 178138 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 1062 | 19 | 10 | 14 | -0.7 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)N3CCCC[C@@H]3C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL1790192 | 484794 | 0 | None | None | None | Rat | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 1034 | 17 | 12 | 15 | -2.8 | CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](N)C(C)(C)SSC[C@@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC1=O | 10.1021/jm00087a009 | ||
| CHEMBL2021547 | 485016 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 1140 | 21 | 11 | 15 | -0.6 | C=C(C)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.ejmech.2008.12.010 | ||
| 45270786 | 392045 | 0 | None | None | None | Rat | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 1168 | 18 | 12 | 13 | 0.8 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(c2ccccc2)c2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1016/j.ejmech.2008.12.010 | ||
| CHEMBL558950 | 392045 | 0 | None | None | None | Rat | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 1168 | 18 | 12 | 13 | 0.8 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(c2ccccc2)c2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1016/j.ejmech.2008.12.010 | ||
| CHEMBL2367696 | 485395 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 1140 | 21 | 11 | 15 | -0.6 | C=C(C)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.ejmech.2008.12.010 | ||
| 42645362 | 387281 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 1128 | 20 | 13 | 14 | -2.2 | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.ejmech.2008.12.010 | ||
| 42645836 | 387281 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 1128 | 20 | 13 | 14 | -2.2 | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.ejmech.2008.12.010 | ||
| CHEMBL538934 | 387281 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 1128 | 20 | 13 | 14 | -2.2 | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.ejmech.2008.12.010 | ||
| CHEMBL541246 | 387281 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 1128 | 20 | 13 | 14 | -2.2 | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.ejmech.2008.12.010 | ||
| 2192 | 4802 | 27 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 471 | 7 | 2 | 5 | 3.7 | CO/N=C/1\CN([C@@H](C1)C(=O)NC[C@H](c1ccccc1)O)C(=O)c1ccc(cc1)c1ccccc1C | 10.1021/jm901812z | ||
| 9690136 | 4802 | 27 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 471 | 7 | 2 | 5 | 3.7 | CO/N=C/1\CN([C@@H](C1)C(=O)NC[C@H](c1ccccc1)O)C(=O)c1ccc(cc1)c1ccccc1C | 10.1021/jm901812z | ||
| CHEMBL1254024 | 4802 | 27 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 471 | 7 | 2 | 5 | 3.7 | CO/N=C/1\CN([C@@H](C1)C(=O)NC[C@H](c1ccccc1)O)C(=O)c1ccc(cc1)c1ccccc1C | 10.1021/jm901812z | ||
| 44429288 | 178241 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 1081 | 19 | 10 | 14 | -0.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| 44429290 | 178241 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 1081 | 19 | 10 | 14 | -0.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL233328 | 178241 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 1081 | 19 | 10 | 14 | -0.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL234377 | 178241 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 1081 | 19 | 10 | 14 | -0.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| 44429307 | 295715 | 0 | None | None | None | Rat | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 1003 | 18 | 10 | 13 | -1.7 | CCc1ccc(C[C@H]2NC(=O)CCSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL394266 | 295715 | 0 | None | None | None | Rat | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 1003 | 18 | 10 | 13 | -1.7 | CCc1ccc(C[C@H]2NC(=O)CCSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| 44408817 | 275347 | 0 | None | None | None | Rat | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 1050 | 17 | 9 | 14 | -2.7 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](N)C(=O)N2CCN(C(=O)[C@@H]2Cc2ccccc2)[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm058038f | ||
| CHEMBL376412 | 275347 | 0 | None | None | None | Rat | 6.8 | pKd | = | 6.8 | Functional | ChEMBL | 1050 | 17 | 9 | 14 | -2.7 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC[C@@H](N)C(=O)N2CCN(C(=O)[C@@H]2Cc2ccccc2)[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm058038f | ||
| CHEMBL1790202 | 484797 | 0 | None | None | None | Rat | 5.8 | pKd | = | 5.8 | Functional | ChEMBL | 1050 | 19 | 13 | 16 | -3.1 | CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](N)C(C)(C)SSC[C@@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CCC(=O)O)NC1=O | 10.1021/jm00087a009 | ||
| 42645362 | 387281 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 1128 | 20 | 13 | 14 | -2.2 | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.ejmech.2008.12.010 | ||
| 42645836 | 387281 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 1128 | 20 | 13 | 14 | -2.2 | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.ejmech.2008.12.010 | ||
| CHEMBL538934 | 387281 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 1128 | 20 | 13 | 14 | -2.2 | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.ejmech.2008.12.010 | ||
| CHEMBL541246 | 387281 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 1128 | 20 | 13 | 14 | -2.2 | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.ejmech.2008.12.010 | ||
| 42646319 | 387973 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 1099 | 18 | 12 | 13 | -0.9 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(c2ccccc2)c2ccccc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1016/j.ejmech.2008.12.010 | ||
| CHEMBL540754 | 387973 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 1099 | 18 | 12 | 13 | -0.9 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C(c2ccccc2)c2ccccc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1016/j.ejmech.2008.12.010 | ||
| CHEMBL1790198 | 484795 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 1049 | 19 | 13 | 16 | -3.7 | CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](N)C(C)(C)SSC[C@@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC1=O | 10.1021/jm00087a009 | ||
| 44429303 | 294155 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 1007 | 20 | 11 | 14 | -1.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL393021 | 294155 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 1007 | 20 | 11 | 14 | -1.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| 44408952 | 312213 | 0 | None | None | None | Rat | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 1103 | 17 | 8 | 13 | 0.1 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC2(CCCCC2)CC(=O)N2CCN(C(=O)[C@@H]2Cc2ccccc2)[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm058038f | ||
| CHEMBL406533 | 312213 | 0 | None | None | None | Rat | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 1103 | 17 | 8 | 13 | 0.1 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSC2(CCCCC2)CC(=O)N2CCN(C(=O)[C@@H]2Cc2ccccc2)[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm058038f | ||
| CHEMBL558740 | 489245 | 0 | None | None | None | Rat | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 1016 | 15 | 13 | 14 | -3.4 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCCC2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1016/j.ejmech.2008.12.010 | ||
| CHEMBL397407 | 487806 | 0 | None | None | None | Rat | 5.6 | pKd | = | 5.6 | Functional | ChEMBL | 1068 | 17 | 12 | 15 | -2.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2Cc3ccccc3C[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | ||
| 16109438 | 196913 | 0 | None | None | None | Human | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 1051 | 17 | 11 | 14 | -1.0 | NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm060928n | ||
| CHEMBL263090 | 196913 | 0 | None | None | None | Human | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 1051 | 17 | 11 | 14 | -1.0 | NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm060928n | ||
| 10461270 | 7472 | 18 | None | None | None | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 603 | 9 | 0 | 5 | 6.9 | CCN(C(=O)c1ccc(c(c1)[C@@]1(C)c2cc(Cl)ccc2N(C1=O)Cc1ccc(cc1OC)OC)Cl)Cc1cccnc1 | 10.1021/jm901812z | ||
| 2201 | 7472 | 18 | None | None | None | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 603 | 9 | 0 | 5 | 6.9 | CCN(C(=O)c1ccc(c(c1)[C@@]1(C)c2cc(Cl)ccc2N(C1=O)Cc1ccc(cc1OC)OC)Cl)Cc1cccnc1 | 10.1021/jm901812z | ||
| CHEMBL1615640 | 7472 | 18 | None | None | None | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 603 | 9 | 0 | 5 | 6.9 | CCN(C(=O)c1ccc(c(c1)[C@@]1(C)c2cc(Cl)ccc2N(C1=O)Cc1ccc(cc1OC)OC)Cl)Cc1cccnc1 | 10.1021/jm901812z | ||
| 16736414 | 178219 | 0 | None | None | None | Rat | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 991 | 19 | 11 | 13 | -1.8 | CCc1ccc(C[C@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| 16736613 | 178219 | 0 | None | None | None | Rat | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 991 | 19 | 11 | 13 | -1.8 | CCc1ccc(C[C@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL233281 | 178219 | 0 | None | None | None | Rat | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 991 | 19 | 11 | 13 | -1.8 | CCc1ccc(C[C@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL394267 | 178219 | 0 | None | None | None | Rat | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 991 | 19 | 11 | 13 | -1.8 | CCc1ccc(C[C@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| 44408951 | 311220 | 0 | None | None | None | Rat | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 1035 | 17 | 8 | 13 | -1.6 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSCCC(=O)N2CCN(C(=O)[C@@H]2Cc2ccccc2)[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm058038f | ||
| CHEMBL402693 | 311220 | 0 | None | None | None | Rat | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 1035 | 17 | 8 | 13 | -1.6 | CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CSSCCC(=O)N2CCN(C(=O)[C@@H]2Cc2ccccc2)[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm058038f | ||
| 16109437 | 175275 | 0 | None | None | None | Human | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 1065 | 18 | 11 | 14 | -0.6 | NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm060928n | ||
| CHEMBL221485 | 175275 | 0 | None | None | None | Human | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 1065 | 18 | 11 | 14 | -0.6 | NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm060928n | ||
| 16737617 | 197207 | 0 | None | None | None | Rat | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 1053 | 17 | 11 | 14 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | ||
| 16737618 | 197207 | 0 | None | None | None | Rat | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 1053 | 17 | 11 | 14 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL265630 | 197207 | 0 | None | None | None | Rat | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 1053 | 17 | 11 | 14 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL415418 | 197207 | 0 | None | None | None | Rat | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 1053 | 17 | 11 | 14 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | ||
| 44429300 | 177895 | 0 | None | None | None | Rat | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 1035 | 18 | 11 | 14 | -1.3 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C(C)(C)C)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL232501 | 177895 | 0 | None | None | None | Rat | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 1035 | 18 | 11 | 14 | -1.3 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C(C)(C)C)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| 16736414 | 178219 | 0 | None | None | None | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 991 | 19 | 11 | 13 | -1.8 | CCc1ccc(C[C@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| 16736613 | 178219 | 0 | None | None | None | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 991 | 19 | 11 | 13 | -1.8 | CCc1ccc(C[C@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL233281 | 178219 | 0 | None | None | None | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 991 | 19 | 11 | 13 | -1.8 | CCc1ccc(C[C@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL394267 | 178219 | 0 | None | None | None | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 991 | 19 | 11 | 13 | -1.8 | CCc1ccc(C[C@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL267214 | 486224 | 0 | None | None | None | Rat | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 1113 | 20 | 15 | 17 | -6.0 | NC(=O)CC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@](N)(CO)CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm058038f | ||
| 44429295 | 333579 | 0 | None | None | None | Rat | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 1110 | 19 | 10 | 14 | -0.1 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL438849 | 333579 | 0 | None | None | None | Rat | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 1110 | 19 | 10 | 14 | -0.1 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL394411 | 487777 | 0 | None | None | None | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 1034 | 19 | 11 | 15 | -2.9 | CCOc1ccc(C[C@H]2NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| 16109444 | 316992 | 0 | None | None | None | Human | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 1037 | 16 | 11 | 14 | -1.3 | NCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm060928n | ||
| CHEMBL412742 | 316992 | 0 | None | None | None | Human | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 1037 | 16 | 11 | 14 | -1.3 | NCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm060928n | ||
| 16109439 | 274647 | 0 | None | None | None | Human | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 1023 | 15 | 11 | 14 | -1.7 | NC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm060928n | ||
| CHEMBL375187 | 274647 | 0 | None | None | None | Human | 6.3 | pKd | = | 6.3 | Functional | ChEMBL | 1023 | 15 | 11 | 14 | -1.7 | NC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm060928n | ||
| 16736414 | 178219 | 0 | None | None | None | Rat | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 991 | 19 | 11 | 13 | -1.8 | CCc1ccc(C[C@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| 16736613 | 178219 | 0 | None | None | None | Rat | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 991 | 19 | 11 | 13 | -1.8 | CCc1ccc(C[C@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL233281 | 178219 | 0 | None | None | None | Rat | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 991 | 19 | 11 | 13 | -1.8 | CCc1ccc(C[C@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL394267 | 178219 | 0 | None | None | None | Rat | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 991 | 19 | 11 | 13 | -1.8 | CCc1ccc(C[C@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| 2213 | 1072 | 37 | None | None | None | Rat | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.ejmech.2006.12.016 | ||
| 3008 | 1072 | 37 | None | None | None | Rat | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.ejmech.2006.12.016 | ||
| 5311010 | 1072 | 37 | None | None | None | Rat | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.ejmech.2006.12.016 | ||
| 68613 | 1072 | 37 | None | None | None | Rat | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL378642 | 1072 | 37 | None | None | None | Rat | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL382301 | 1072 | 37 | None | None | None | Rat | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.ejmech.2006.12.016 | ||
| DB09059 | 1072 | 37 | None | None | None | Rat | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL563952 | 489255 | 0 | None | None | None | Rat | 7.3 | pKd | = | 7.3 | Functional | ChEMBL | 1079 | 17 | 14 | 15 | -5.0 | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)NC2(Cc3ccccc3C2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.ejmech.2008.12.010 | ||
| 44409014 | 330957 | 0 | None | None | None | Rat | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 1144 | 20 | 13 | 15 | -2.8 | NC(=O)CC[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(c2ccccc2)c2ccccc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm058038f | ||
| CHEMBL425991 | 330957 | 0 | None | None | None | Rat | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 1144 | 20 | 13 | 15 | -2.8 | NC(=O)CC[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(c2ccccc2)c2ccccc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm058038f | ||
| 45270785 | 390330 | 0 | None | None | None | Rat | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 1197 | 20 | 13 | 14 | -0.5 | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC2(CCCCC2)CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.ejmech.2008.12.010 | ||
| CHEMBL552946 | 390330 | 0 | None | None | None | Rat | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 1197 | 20 | 13 | 14 | -0.5 | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC2(CCCCC2)CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.ejmech.2008.12.010 | ||
| 44429288 | 178241 | 0 | None | None | None | Rat | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 1081 | 19 | 10 | 14 | -0.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| 44429290 | 178241 | 0 | None | None | None | Rat | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 1081 | 19 | 10 | 14 | -0.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL233328 | 178241 | 0 | None | None | None | Rat | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 1081 | 19 | 10 | 14 | -0.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL234377 | 178241 | 0 | None | None | None | Rat | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 1081 | 19 | 10 | 14 | -0.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| 56668141 | 125900 | 0 | None | None | None | Rat | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 989 | 9 | 11 | 14 | -2.8 | CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H]2NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(=O)NCCCC[C@H](C(=O)NCC(N)=O)NC(=O)[C@H]3CCCN3C2=O)NC1=O | 10.1021/jm00087a009 | ||
| CHEMBL1790201 | 125900 | 0 | None | None | None | Rat | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 989 | 9 | 11 | 14 | -2.8 | CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H]2NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(=O)NCCCC[C@H](C(=O)NCC(N)=O)NC(=O)[C@H]3CCCN3C2=O)NC1=O | 10.1021/jm00087a009 | ||
| 42645362 | 387281 | 0 | None | None | None | Rat | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 1128 | 20 | 13 | 14 | -2.2 | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.ejmech.2008.12.010 | ||
| 42645836 | 387281 | 0 | None | None | None | Rat | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 1128 | 20 | 13 | 14 | -2.2 | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.ejmech.2008.12.010 | ||
| CHEMBL538934 | 387281 | 0 | None | None | None | Rat | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 1128 | 20 | 13 | 14 | -2.2 | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.ejmech.2008.12.010 | ||
| CHEMBL541246 | 387281 | 0 | None | None | None | Rat | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 1128 | 20 | 13 | 14 | -2.2 | N=C(N)NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1016/j.ejmech.2008.12.010 | ||
| 45267363 | 390427 | 0 | None | None | None | Rat | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 1107 | 17 | 12 | 14 | -1.2 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1016/j.ejmech.2008.12.010 | ||
| CHEMBL553710 | 390427 | 0 | None | None | None | Rat | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 1107 | 17 | 12 | 14 | -1.2 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1016/j.ejmech.2008.12.010 | ||
| CHEMBL415417 | 488399 | 0 | None | None | None | Rat | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 1022 | 16 | 13 | 15 | -3.1 | CC(C)C[C@H](NC(=O)[C@H](NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(C)(C)C)C(=O)NCC(N)=O | 10.1016/j.ejmech.2006.12.016 | ||
| 44408750 | 312534 | 0 | None | None | None | Rat | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 1213 | 20 | 13 | 15 | -1.0 | NC(=O)CC[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(c2ccccc2)c2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm058038f | ||
| CHEMBL406896 | 312534 | 0 | None | None | None | Rat | 6.1 | pKd | = | 6.1 | Functional | ChEMBL | 1213 | 20 | 13 | 15 | -1.0 | NC(=O)CC[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(c2ccccc2)c2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm058038f | ||
| 44429294 | 333024 | 0 | None | None | None | Rat | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 1184 | 18 | 9 | 14 | 0.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)N3Cc4ccccc4C[C@@H]3C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL434193 | 333024 | 0 | None | None | None | Rat | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 1184 | 18 | 9 | 14 | 0.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)N3Cc4ccccc4C[C@@H]3C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| 44429307 | 295715 | 0 | None | None | None | Rat | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 1003 | 18 | 10 | 13 | -1.7 | CCc1ccc(C[C@H]2NC(=O)CCSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| CHEMBL394266 | 295715 | 0 | None | None | None | Rat | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 1003 | 18 | 10 | 13 | -1.7 | CCc1ccc(C[C@H]2NC(=O)CCSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | ||
| 46225048 | 465179 | 0 | None | None | None | Human | 9.4 | pKi | = | 9.4 | Functional | ChEMBL | 415 | 5 | 0 | 7 | 3.6 | COc1ccc(-n2c(C)nnc2N2CCC(Oc3cc(F)cc(F)c3C)CC2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| CHEMBL606976 | 465179 | 0 | None | None | None | Human | 9.4 | pKi | = | 9.4 | Functional | ChEMBL | 415 | 5 | 0 | 7 | 3.6 | COc1ccc(-n2c(C)nnc2N2CCC(Oc3cc(F)cc(F)c3C)CC2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| 42611262 | 354432 | 0 | None | None | None | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 349 | 6 | 0 | 2 | 4.7 | Cc1cc(C(=O)N(CC2CC2)CC2CCCO2)ccc1-c1ccccc1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL475395 | 354432 | 0 | None | None | None | Human | 9.1 | pKi | = | 9.1 | Functional | ChEMBL | 349 | 6 | 0 | 2 | 4.7 | Cc1cc(C(=O)N(CC2CC2)CC2CCCO2)ccc1-c1ccccc1 | 10.1016/j.bmcl.2008.11.064 | ||
| 11848692 | 352443 | 1 | None | None | None | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 396 | 4 | 0 | 7 | 3.9 | COc1ccc(-n2c(C)nnc2-c2cnc(-c3cccc(F)c3Cl)cn2)cn1 | 10.1016/j.bmcl.2008.06.098 | ||
| CHEMBL466762 | 352443 | 1 | None | None | None | Human | 9.0 | pKi | = | 9 | Functional | ChEMBL | 396 | 4 | 0 | 7 | 3.9 | COc1ccc(-n2c(C)nnc2-c2cnc(-c3cccc(F)c3Cl)cn2)cn1 | 10.1016/j.bmcl.2008.06.098 | ||
| 2202 | 5638 | 34 | None | None | None | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 10.1016/j.bmcl.2010.11.061 | ||
| 9895468 | 5638 | 34 | None | None | None | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 10.1016/j.bmcl.2010.11.061 | ||
| CHEMBL582857 | 5638 | 34 | None | None | None | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 10.1016/j.bmcl.2010.11.061 | ||
| DB12643 | 5638 | 34 | None | None | None | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 10.1016/j.bmcl.2010.11.061 | ||
| 11465834 | 275790 | 0 | None | None | None | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 483 | 6 | 1 | 3 | 3.3 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(F)cc1F | 10.1021/jm060073e | ||
| CHEMBL377414 | 275790 | 0 | None | None | None | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 483 | 6 | 1 | 3 | 3.3 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(F)cc1F | 10.1021/jm060073e | ||
| 44581242 | 349863 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 475 | 8 | 0 | 6 | 4.9 | COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3C)cn2)c2ccc(OC)nc2)cc1 | 10.1016/j.bmcl.2008.11.018 | ||
| CHEMBL458635 | 349863 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 475 | 8 | 0 | 6 | 4.9 | COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3C)cn2)c2ccc(OC)nc2)cc1 | 10.1016/j.bmcl.2008.11.018 | ||
| 44571488 | 367153 | 0 | None | None | None | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 396 | 6 | 0 | 3 | 5.0 | N#Cc1ccccc1-c1ccc(C(=O)N(Cc2ccccc2)CC2CCCO2)cc1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL480584 | 367153 | 0 | None | None | None | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 396 | 6 | 0 | 3 | 5.0 | N#Cc1ccccc1-c1ccc(C(=O)N(Cc2ccccc2)CC2CCCO2)cc1 | 10.1016/j.bmcl.2008.11.064 | ||
| 44571389 | 367387 | 0 | None | None | None | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 440 | 6 | 0 | 3 | 5.6 | O=C(c1ccc(-c2ncccc2C(F)(F)F)cc1)N(Cc1ccccc1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL482322 | 367387 | 0 | None | None | None | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 440 | 6 | 0 | 3 | 5.6 | O=C(c1ccc(-c2ncccc2C(F)(F)F)cc1)N(Cc1ccccc1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| 71452693 | 160180 | 0 | None | None | None | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 711 | 8 | 6 | 7 | 2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CCCSC[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@H](C)CC)NC1=O | 10.1016/s0960-894x(99)00478-3 | ||
| CHEMBL2112376 | 160180 | 0 | None | None | None | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 711 | 8 | 6 | 7 | 2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CCCSC[C@@H]2CCCN2C(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@H](C)CC)NC1=O | 10.1016/s0960-894x(99)00478-3 | ||
| 44579401 | 370348 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 354 | 7 | 0 | 7 | 3.2 | CCOc1ccc(-c2nnc(COC)n2-c2ccc(OC)nc2)cc1C | 10.1016/j.bmcl.2008.08.066 | ||
| CHEMBL491422 | 370348 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 354 | 7 | 0 | 7 | 3.2 | CCOc1ccc(-c2nnc(COC)n2-c2ccc(OC)nc2)cc1C | 10.1016/j.bmcl.2008.08.066 | ||
| 46830094 | 22748 | 0 | None | None | None | Human | 8.0 | pKi | = | 8.0 | Functional | ChEMBL | 392 | 7 | 0 | 6 | 3.5 | COCCN(C(=O)c1cnc(-c2cccc(C)c2C)cn1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1093599 | 22748 | 0 | None | None | None | Human | 8.0 | pKi | = | 8.0 | Functional | ChEMBL | 392 | 7 | 0 | 6 | 3.5 | COCCN(C(=O)c1cnc(-c2cccc(C)c2C)cn1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| 46881861 | 22588 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 345 | 4 | 0 | 4 | 2.9 | COc1ccc(N(C)C(=O)N2CC(Oc3ccc(F)cc3C)C2)cn1 | 10.1016/j.bmcl.2010.01.143 | ||
| CHEMBL1092499 | 22588 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 345 | 4 | 0 | 4 | 2.9 | COc1ccc(N(C)C(=O)N2CC(Oc3ccc(F)cc3C)C2)cn1 | 10.1016/j.bmcl.2010.01.143 | ||
| 46225023 | 431903 | 1 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 365 | 5 | 0 | 7 | 3.0 | COc1ccc(-n2c(C)nnc2N2CCC(Oc3ccccc3)CC2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| CHEMBL592250 | 431903 | 1 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 365 | 5 | 0 | 7 | 3.0 | COc1ccc(-n2c(C)nnc2N2CCC(Oc3ccccc3)CC2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| 46884439 | 22717 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 378 | 7 | 0 | 6 | 3.1 | COCCN(C(=O)c1cnc(-c2ccccc2C)cn1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1093365 | 22717 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 378 | 7 | 0 | 6 | 3.1 | COCCN(C(=O)c1cnc(-c2ccccc2C)cn1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| 45271574 | 393549 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 374 | 5 | 0 | 8 | 3.5 | COc1ccc(-n2c(C)nnc2-c2cnc(Oc3ccccc3C)cn2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| CHEMBL563905 | 393549 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 374 | 5 | 0 | 8 | 3.5 | COc1ccc(-n2c(C)nnc2-c2cnc(Oc3ccccc3C)cn2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| 44572048 | 372639 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 349 | 6 | 0 | 2 | 4.7 | Cc1cc(-c2ccccc2)ccc1C(=O)N(CC1CC1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL514031 | 372639 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 349 | 6 | 0 | 2 | 4.7 | Cc1cc(-c2ccccc2)ccc1C(=O)N(CC1CC1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| 46884437 | 22058 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 348 | 5 | 0 | 5 | 3.5 | CCN(C(=O)c1cnc(-c2ccccc2C)cn1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1089025 | 22058 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 348 | 5 | 0 | 5 | 3.5 | CCN(C(=O)c1cnc(-c2ccccc2C)cn1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| 46844643 | 19935 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 359 | 5 | 0 | 4 | 3.2 | CCN(C(=O)N1CC(Oc2cccc(F)c2C)C1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.01.143 | ||
| CHEMBL1077300 | 19935 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 359 | 5 | 0 | 4 | 3.2 | CCN(C(=O)N1CC(Oc2cccc(F)c2C)C1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.01.143 | ||
| 46830095 | 22579 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 376 | 5 | 0 | 5 | 4.2 | COc1ccc(N(C(=O)c2cnc(-c3cccc(C)c3C)cn2)C(C)C)cn1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1092459 | 22579 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 376 | 5 | 0 | 5 | 4.2 | COc1ccc(N(C(=O)c2cnc(-c3cccc(C)c3C)cn2)C(C)C)cn1 | 10.1016/j.bmcl.2010.02.018 | ||
| 11475469 | 352696 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 413 | 6 | 0 | 9 | 3.1 | COCc1nnc(-c2cnc(-c3ccc(C#N)cc3C)cn2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2008.06.098 | ||
| CHEMBL469005 | 352696 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 413 | 6 | 0 | 9 | 3.1 | COCc1nnc(-c2cnc(-c3ccc(C#N)cc3C)cn2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2008.06.098 | ||
| 45271580 | 389597 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 392 | 5 | 0 | 8 | 3.7 | COc1ccc(-n2c(C)nnc2-c2cnc(Oc3cccc(F)c3C)cn2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| CHEMBL549494 | 389597 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 392 | 5 | 0 | 8 | 3.7 | COc1ccc(-n2c(C)nnc2-c2cnc(Oc3cccc(F)c3C)cn2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| 4353841 | 372414 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 341 | 4 | 0 | 4 | 4.9 | COc1ccc(-n2c(C)nnc2-c2ccc(-c3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2008.06.098 | ||
| CHEMBL511908 | 372414 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 341 | 4 | 0 | 4 | 4.9 | COc1ccc(-n2c(C)nnc2-c2ccc(-c3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2008.06.098 | ||
| 44579400 | 370347 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 324 | 5 | 0 | 6 | 3.4 | CCOc1ccc(-c2nnc(C)n2-c2ccc(OC)nc2)cc1C | 10.1016/j.bmcl.2008.08.066 | ||
| CHEMBL491421 | 370347 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 324 | 5 | 0 | 6 | 3.4 | CCOc1ccc(-c2nnc(C)n2-c2ccc(OC)nc2)cc1C | 10.1016/j.bmcl.2008.08.066 | ||
| 44579441 | 370090 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 374 | 7 | 0 | 7 | 3.5 | CCOc1ccc(-c2nnc(COC)n2-c2ccc(OC)nc2)cc1Cl | 10.1016/j.bmcl.2008.08.066 | ||
| CHEMBL489386 | 370090 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 374 | 7 | 0 | 7 | 3.5 | CCOc1ccc(-c2nnc(COC)n2-c2ccc(OC)nc2)cc1Cl | 10.1016/j.bmcl.2008.08.066 | ||
| 44571386 | 367388 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 403 | 6 | 0 | 2 | 5.6 | Cc1cc(F)ccc1-c1ccc(C(=O)N(Cc2ccccc2)CC2CCCO2)cc1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL482323 | 367388 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 403 | 6 | 0 | 2 | 5.6 | Cc1cc(F)ccc1-c1ccc(C(=O)N(Cc2ccccc2)CC2CCCO2)cc1 | 10.1016/j.bmcl.2008.11.064 | ||
| 46884438 | 22059 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 362 | 5 | 0 | 5 | 3.9 | COc1ccc(N(C(=O)c2cnc(-c3ccccc3C)cn2)C(C)C)cn1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1089026 | 22059 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 362 | 5 | 0 | 5 | 3.9 | COc1ccc(N(C(=O)c2cnc(-c3ccccc3C)cn2)C(C)C)cn1 | 10.1016/j.bmcl.2010.02.018 | ||
| 46881859 | 22586 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 345 | 4 | 0 | 4 | 2.9 | COc1ccc(N(C)C(=O)N2CC(Oc3cccc(F)c3C)C2)cn1 | 10.1016/j.bmcl.2010.01.143 | ||
| CHEMBL1092497 | 22586 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 345 | 4 | 0 | 4 | 2.9 | COc1ccc(N(C)C(=O)N2CC(Oc3cccc(F)c3C)C2)cn1 | 10.1016/j.bmcl.2010.01.143 | ||
| 44577937 | 352493 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 402 | 7 | 0 | 7 | 4.2 | COCc1nnc(-c2ccc(-c3ccccc3OC)cc2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2008.06.098 | ||
| CHEMBL467185 | 352493 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 402 | 7 | 0 | 7 | 4.2 | COCc1nnc(-c2ccc(-c3ccccc3OC)cc2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2008.06.098 | ||
| 44577939 | 372341 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 406 | 6 | 0 | 8 | 3.4 | COCc1nnc(-c2cnc(-c3ccc(F)c(C)c3)cn2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2008.06.098 | ||
| CHEMBL511265 | 372341 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 406 | 6 | 0 | 8 | 3.4 | COCc1nnc(-c2cnc(-c3ccc(F)c(C)c3)cn2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2008.06.098 | ||
| 11667812 | 443991 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 369 | 5 | 0 | 7 | 2.7 | COc1ccc(-n2c(C)nnc2N2CC(Oc3ccc(F)cc3C)C2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| CHEMBL594591 | 443991 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 369 | 5 | 0 | 7 | 2.7 | COc1ccc(-n2c(C)nnc2N2CC(Oc3ccc(F)cc3C)C2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| 11667812 | 443991 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 369 | 5 | 0 | 7 | 2.7 | COc1ccc(-n2c(C)nnc2N2CC(Oc3ccc(F)cc3C)C2)cn1 | 10.1016/j.bmcl.2010.01.143 | ||
| CHEMBL594591 | 443991 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 369 | 5 | 0 | 7 | 2.7 | COc1ccc(-n2c(C)nnc2N2CC(Oc3ccc(F)cc3C)C2)cn1 | 10.1016/j.bmcl.2010.01.143 | ||
| 46225080 | 432399 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 413 | 7 | 0 | 8 | 2.9 | COCc1nnc(N2CC[C@@H](Oc3ccc(F)cc3C)C2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2009.11.097 | ||
| CHEMBL592732 | 432399 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 413 | 7 | 0 | 8 | 2.9 | COCc1nnc(N2CC[C@@H](Oc3ccc(F)cc3C)C2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2009.11.097 | ||
| 46225049 | 452021 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 351 | 5 | 0 | 7 | 2.6 | COc1ccc(-n2c(C)nnc2N2CC[C@@H](Oc3ccccc3)C2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| CHEMBL603205 | 452021 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 351 | 5 | 0 | 7 | 2.6 | COc1ccc(-n2c(C)nnc2N2CC[C@@H](Oc3ccccc3)C2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| 46225153 | 428769 | 0 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 399 | 7 | 0 | 8 | 2.5 | COCc1nnc(N2CC(Oc3ccc(F)cc3C)C2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2009.11.097 | ||
| CHEMBL589128 | 428769 | 0 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 399 | 7 | 0 | 8 | 2.5 | COCc1nnc(N2CC(Oc3ccc(F)cc3C)C2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2009.11.097 | ||
| 11486351 | 385523 | 0 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 398 | 10 | 0 | 8 | 3.2 | CCOc1ccc(-c2nnc(COCCOC)n2-c2ccc(OC)nc2)cc1C | 10.1016/j.bmcl.2008.08.066 | ||
| CHEMBL522255 | 385523 | 0 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 398 | 10 | 0 | 8 | 3.2 | CCOc1ccc(-c2nnc(COCCOC)n2-c2ccc(OC)nc2)cc1C | 10.1016/j.bmcl.2008.08.066 | ||
| 46881932 | 22105 | 0 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 369 | 5 | 0 | 7 | 2.7 | COc1ccc(-n2c(C)nnc2N2CC(Oc3cccc(F)c3C)C2)cn1 | 10.1016/j.bmcl.2010.01.143 | ||
| CHEMBL1089391 | 22105 | 0 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 369 | 5 | 0 | 7 | 2.7 | COc1ccc(-n2c(C)nnc2N2CC(Oc3cccc(F)c3C)C2)cn1 | 10.1016/j.bmcl.2010.01.143 | ||
| 44579402 | 385200 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 408 | 7 | 0 | 7 | 3.9 | CCOc1ccc(-c2nnc(COC)n2-c2ccc(OC)nc2)cc1C(F)(F)F | 10.1016/j.bmcl.2008.08.066 | ||
| CHEMBL521789 | 385200 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 408 | 7 | 0 | 7 | 3.9 | CCOc1ccc(-c2nnc(COC)n2-c2ccc(OC)nc2)cc1C(F)(F)F | 10.1016/j.bmcl.2008.08.066 | ||
| 45268188 | 392893 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 406 | 6 | 0 | 9 | 4.0 | COc1ccc(-n2c(C)nnc2-c2cnc(Oc3ccccc3SC)cn2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| CHEMBL561520 | 392893 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 406 | 6 | 0 | 9 | 4.0 | COc1ccc(-n2c(C)nnc2-c2cnc(Oc3ccccc3SC)cn2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| 44571492 | 367292 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 404 | 6 | 0 | 3 | 4.8 | O=C(c1ccc(-c2ncccc2C(F)(F)F)cc1)N(CC1CC1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL481730 | 367292 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 404 | 6 | 0 | 3 | 4.8 | O=C(c1ccc(-c2ncccc2C(F)(F)F)cc1)N(CC1CC1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| 5002508 | 350034 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 460 | 6 | 0 | 5 | 4.4 | COc1ccc(N(Cc2cc3cccc4c3n(c2=O)CCC4)S(=O)(=O)c2ccccc2)cc1 | 10.1016/j.bmcl.2008.11.018 | ||
| CHEMBL459073 | 350034 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 460 | 6 | 0 | 5 | 4.4 | COc1ccc(N(Cc2cc3cccc4c3n(c2=O)CCC4)S(=O)(=O)c2ccccc2)cc1 | 10.1016/j.bmcl.2008.11.018 | ||
| 44572047 | 354576 | 0 | None | None | None | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 360 | 6 | 0 | 3 | 4.3 | N#Cc1ccccc1-c1ccc(C(=O)N(CC2CC2)CC2CCCO2)cc1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL475561 | 354576 | 0 | None | None | None | Human | 5.7 | pKi | = | 5.7 | Functional | ChEMBL | 360 | 6 | 0 | 3 | 4.3 | N#Cc1ccccc1-c1ccc(C(=O)N(CC2CC2)CC2CCCO2)cc1 | 10.1016/j.bmcl.2008.11.064 | ||
| 53325929 | 119569 | 0 | None | None | None | Human | 4.7 | pKi | = | 4.7 | Functional | ChEMBL | 537 | 11 | 1 | 7 | 5.8 | COc1ccc(S(=O)(=O)N(Cc2csc(-c3ccc(CNCc4ccoc4)cc3)n2)C2CCCC2)cc1 | 10.1016/j.bmcl.2010.11.061 | ||
| CHEMBL1643590 | 119569 | 0 | None | None | None | Human | 4.7 | pKi | = | 4.7 | Functional | ChEMBL | 537 | 11 | 1 | 7 | 5.8 | COc1ccc(S(=O)(=O)N(Cc2csc(-c3ccc(CNCc4ccoc4)cc3)n2)C2CCCC2)cc1 | 10.1016/j.bmcl.2010.11.061 | ||
| 44577982 | 352549 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 378 | 4 | 0 | 7 | 3.8 | COc1ccc(-n2c(C)nnc2-c2cnc(-c3ccccc3Cl)cn2)cn1 | 10.1016/j.bmcl.2008.06.098 | ||
| CHEMBL467545 | 352549 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 378 | 4 | 0 | 7 | 3.8 | COc1ccc(-n2c(C)nnc2-c2cnc(-c3ccccc3Cl)cn2)cn1 | 10.1016/j.bmcl.2008.06.098 | ||
| 11502419 | 432150 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 409 | 7 | 0 | 8 | 3.2 | COCc1nnc(N2CCC(Oc3ccccc3C)CC2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2009.11.097 | ||
| CHEMBL592495 | 432150 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Functional | ChEMBL | 409 | 7 | 0 | 8 | 3.2 | COCc1nnc(N2CCC(Oc3ccccc3C)CC2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2009.11.097 | ||
| 11618185 | 451415 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 397 | 5 | 0 | 7 | 3.5 | COc1ccc(-n2c(C)nnc2N2CCC(Oc3cccc(F)c3C)CC2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| CHEMBL602545 | 451415 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 397 | 5 | 0 | 7 | 3.5 | COc1ccc(-n2c(C)nnc2N2CCC(Oc3cccc(F)c3C)CC2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| 15548578 | 160182 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 742 | 12 | 8 | 8 | 1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CCCSC[C@@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@H](C)CC)NC1=O | 10.1016/s0960-894x(99)00478-3 | ||
| CHEMBL2112378 | 160182 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 742 | 12 | 8 | 8 | 1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CCCSC[C@@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@H](C)CC)NC1=O | 10.1016/s0960-894x(99)00478-3 | ||
| 2252 | 4546 | 39 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/j.bmcl.2008.06.098 | ||
| 6918320 | 4546 | 39 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/j.bmcl.2008.06.098 | ||
| CHEMBL24781 | 4546 | 39 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/j.bmcl.2008.06.098 | ||
| 44578010 | 372331 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 402 | 6 | 0 | 8 | 3.6 | COCc1nnc(-c2cnc(-c3ccc(C)c(C)c3)cn2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2008.06.098 | ||
| CHEMBL511215 | 372331 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 402 | 6 | 0 | 8 | 3.6 | COCc1nnc(-c2cnc(-c3ccc(C)c(C)c3)cn2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2008.06.098 | ||
| 46225082 | 432402 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 395 | 7 | 0 | 8 | 2.8 | COCc1nnc(N2CC[C@H](Oc3ccccc3C)C2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2009.11.097 | ||
| CHEMBL592733 | 432402 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 395 | 7 | 0 | 8 | 2.8 | COCc1nnc(N2CC[C@H](Oc3ccccc3C)C2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2009.11.097 | ||
| 46884440 | 22718 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 352 | 4 | 0 | 5 | 3.3 | COc1ccc(N(C)C(=O)c2cnc(-c3ccc(F)cc3C)cn2)cn1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1093366 | 22718 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 352 | 4 | 0 | 5 | 3.3 | COc1ccc(N(C)C(=O)c2cnc(-c3ccc(F)cc3C)cn2)cn1 | 10.1016/j.bmcl.2010.02.018 | ||
| 45272485 | 393232 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 394 | 5 | 0 | 8 | 3.9 | COc1ccc(-n2c(C)nnc2-c2cnc(Oc3ccccc3Cl)cn2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| CHEMBL562946 | 393232 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 394 | 5 | 0 | 8 | 3.9 | COc1ccc(-n2c(C)nnc2-c2cnc(Oc3ccccc3Cl)cn2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| 46883884 | 22714 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 312 | 4 | 0 | 5 | 3.1 | COc1ccc2oc(C(=O)N(C)c3ccc(OC)nc3)cc2c1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1093340 | 22714 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 312 | 4 | 0 | 5 | 3.1 | COc1ccc2oc(C(=O)N(C)c3ccc(OC)nc3)cc2c1 | 10.1016/j.bmcl.2010.02.018 | ||
| 44577983 | 352550 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 418 | 6 | 0 | 8 | 4.5 | CCSc1ccc(-c2cnc(-c3nnc(C)n3-c3ccc(OC)nc3)cn2)c(C)c1 | 10.1016/j.bmcl.2008.06.098 | ||
| CHEMBL467546 | 352550 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 418 | 6 | 0 | 8 | 4.5 | CCSc1ccc(-c2cnc(-c3nnc(C)n3-c3ccc(OC)nc3)cn2)c(C)c1 | 10.1016/j.bmcl.2008.06.098 | ||
| 46881860 | 22587 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 363 | 4 | 0 | 4 | 3.0 | COc1ccc(N(C)C(=O)N2CC(Oc3cc(F)cc(F)c3C)C2)cn1 | 10.1016/j.bmcl.2010.01.143 | ||
| CHEMBL1092498 | 22587 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 363 | 4 | 0 | 4 | 3.0 | COc1ccc(N(C)C(=O)N2CC(Oc3cc(F)cc(F)c3C)C2)cn1 | 10.1016/j.bmcl.2010.01.143 | ||
| 46830096 | 22312 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 362 | 5 | 0 | 5 | 3.8 | CCN(C(=O)c1cnc(-c2cccc(C)c2C)cn1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1090654 | 22312 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 362 | 5 | 0 | 5 | 3.8 | CCN(C(=O)c1cnc(-c2cccc(C)c2C)cn1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| 46883886 | 22716 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 328 | 7 | 0 | 4 | 3.6 | CCN(C(=O)COc1ccc(C(C)C)cc1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1093342 | 22716 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 328 | 7 | 0 | 4 | 3.6 | CCN(C(=O)COc1ccc(C(C)C)cc1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| 53316694 | 119564 | 0 | None | None | None | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 513 | 11 | 1 | 6 | 5.7 | COc1ccc(S(=O)(=O)N(Cc2csc(-c3ccc(CNCC(C)C)cc3)n2)C2CCCC2)cc1 | 10.1016/j.bmcl.2010.11.061 | ||
| CHEMBL1643585 | 119564 | 0 | None | None | None | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 513 | 11 | 1 | 6 | 5.7 | COc1ccc(S(=O)(=O)N(Cc2csc(-c3ccc(CNCC(C)C)cc3)n2)C2CCCC2)cc1 | 10.1016/j.bmcl.2010.11.061 | ||
| 53316695 | 119566 | 0 | None | None | None | Human | 4.6 | pKi | = | 4.6 | Functional | ChEMBL | 527 | 10 | 1 | 6 | 6.1 | COc1ccc(S(=O)(=O)N(Cc2csc(-c3ccc(CNCC(C)(C)C)cc3)n2)C2CCCC2)cc1 | 10.1016/j.bmcl.2010.11.061 | ||
| CHEMBL1643587 | 119566 | 0 | None | None | None | Human | 4.6 | pKi | = | 4.6 | Functional | ChEMBL | 527 | 10 | 1 | 6 | 6.1 | COc1ccc(S(=O)(=O)N(Cc2csc(-c3ccc(CNCC(C)(C)C)cc3)n2)C2CCCC2)cc1 | 10.1016/j.bmcl.2010.11.061 | ||
| 45270760 | 389620 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 390 | 6 | 0 | 9 | 3.2 | COc1ccc(-n2c(C)nnc2-c2cnc(Oc3ccccc3OC)cn2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| CHEMBL549633 | 389620 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 390 | 6 | 0 | 9 | 3.2 | COc1ccc(-n2c(C)nnc2-c2cnc(Oc3ccccc3OC)cn2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| 15548579 | 221104 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 728 | 11 | 8 | 8 | 1.4 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CCCSC[C@H](CCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@H](C)CC)NC1=O | 10.1016/s0960-894x(99)00478-3 | ||
| CHEMBL328348 | 221104 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 728 | 11 | 8 | 8 | 1.4 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CCCSC[C@H](CCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@H](C)CC)NC1=O | 10.1016/s0960-894x(99)00478-3 | ||
| 44579399 | 370412 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 368 | 8 | 0 | 7 | 3.6 | CCOCc1nnc(-c2ccc(OCC)c(C)c2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2008.08.066 | ||
| CHEMBL492029 | 370412 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 368 | 8 | 0 | 7 | 3.6 | CCOCc1nnc(-c2ccc(OCC)c(C)c2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2008.08.066 | ||
| 11574636 | 428764 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 389 | 5 | 0 | 7 | 3.0 | COc1ccc(-n2c(C)nnc2N2CC(Oc3ccc(F)cc3Cl)C2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| CHEMBL589125 | 428764 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 389 | 5 | 0 | 7 | 3.0 | COc1ccc(-n2c(C)nnc2N2CC(Oc3ccc(F)cc3Cl)C2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| 11574636 | 428764 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 389 | 5 | 0 | 7 | 3.0 | COc1ccc(-n2c(C)nnc2N2CC(Oc3ccc(F)cc3Cl)C2)cn1 | 10.1016/j.bmcl.2010.01.143 | ||
| CHEMBL589125 | 428764 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 389 | 5 | 0 | 7 | 3.0 | COc1ccc(-n2c(C)nnc2N2CC(Oc3ccc(F)cc3Cl)C2)cn1 | 10.1016/j.bmcl.2010.01.143 | ||
| 46225079 | 429761 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 395 | 7 | 0 | 8 | 2.8 | COCc1nnc(N2CC[C@@H](Oc3ccccc3C)C2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2009.11.097 | ||
| CHEMBL590097 | 429761 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 395 | 7 | 0 | 8 | 2.8 | COCc1nnc(N2CC[C@@H](Oc3ccccc3C)C2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2009.11.097 | ||
| 46884480 | 22578 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 366 | 5 | 0 | 5 | 3.7 | CCN(C(=O)c1cnc(-c2cccc(F)c2C)cn1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1092458 | 22578 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 366 | 5 | 0 | 5 | 3.7 | CCN(C(=O)c1cnc(-c2cccc(F)c2C)cn1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| 11260438 | 197937 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | Cc1nc([C@H](C(=O)N2CCOCC2)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)co1 | 10.1016/j.bmcl.2008.06.098 | ||
| 44577873 | 197937 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | Cc1nc([C@H](C(=O)N2CCOCC2)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)co1 | 10.1016/j.bmcl.2008.06.098 | ||
| CHEMBL271039 | 197937 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | Cc1nc([C@H](C(=O)N2CCOCC2)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)co1 | 10.1016/j.bmcl.2008.06.098 | ||
| CHEMBL513488 | 197937 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | Cc1nc([C@H](C(=O)N2CCOCC2)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)co1 | 10.1016/j.bmcl.2008.06.098 | ||
| 44571491 | 367271 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 367 | 6 | 0 | 2 | 4.8 | Cc1cc(F)ccc1-c1ccc(C(=O)N(CC2CC2)CC2CCCO2)cc1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL481569 | 367271 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 367 | 6 | 0 | 2 | 4.8 | Cc1cc(F)ccc1-c1ccc(C(=O)N(CC2CC2)CC2CCCO2)cc1 | 10.1016/j.bmcl.2008.11.064 | ||
| 44572003 | 372756 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 369 | 6 | 0 | 2 | 5.0 | O=C(c1ccc(-c2ccccc2Cl)cc1)N(CC1CC1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL514975 | 372756 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 369 | 6 | 0 | 2 | 5.0 | O=C(c1ccc(-c2ccccc2Cl)cc1)N(CC1CC1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| 44581241 | 349862 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 495 | 8 | 0 | 6 | 5.2 | COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3Cl)cn2)c2ccc(OC)nc2)cc1 | 10.1016/j.bmcl.2008.11.018 | ||
| CHEMBL458634 | 349862 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 495 | 8 | 0 | 6 | 5.2 | COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3Cl)cn2)c2ccc(OC)nc2)cc1 | 10.1016/j.bmcl.2008.11.018 | ||
| 11488952 | 159212 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 501 | 7 | 2 | 4 | 4.2 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc2occc2c1 | 10.1021/jm060073e | ||
| CHEMBL208787 | 159212 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 501 | 7 | 2 | 4 | 4.2 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc2occc2c1 | 10.1021/jm060073e | ||
| 46225083 | 443763 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 337 | 5 | 0 | 7 | 2.2 | COc1ccc(-n2c(C)nnc2N2CC(Oc3ccccc3)C2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| CHEMBL594361 | 443763 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 337 | 5 | 0 | 7 | 2.2 | COc1ccc(-n2c(C)nnc2N2CC(Oc3ccccc3)C2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| 44215484 | 352491 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 440 | 7 | 0 | 6 | 4.6 | Cc1nnc(-c2ccc(-c3ccccc3)cc2)n1-c1ccccc1OCCN1CCOCC1 | 10.1016/j.bmcl.2008.06.098 | ||
| CHEMBL467154 | 352491 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 440 | 7 | 0 | 6 | 4.6 | Cc1nnc(-c2ccc(-c3ccccc3)cc2)n1-c1ccccc1OCCN1CCOCC1 | 10.1016/j.bmcl.2008.06.098 | ||
| 46225051 | 430998 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 383 | 5 | 0 | 7 | 3.1 | COc1ccc(-n2c(C)nnc2N2CC[C@@H](Oc3ccc(F)cc3C)C2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| CHEMBL591310 | 430998 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 383 | 5 | 0 | 7 | 3.1 | COc1ccc(-n2c(C)nnc2N2CC[C@@H](Oc3ccc(F)cc3C)C2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| 44571529 | 372818 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 404 | 6 | 0 | 3 | 4.8 | O=C(c1ccc(-c2ccccc2C(F)(F)F)nc1)N(CC1CC1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL515447 | 372818 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 404 | 6 | 0 | 3 | 4.8 | O=C(c1ccc(-c2ccccc2C(F)(F)F)nc1)N(CC1CC1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| 45483204 | 404679 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 619 | 11 | 1 | 7 | 4.6 | COc1ccc(S(=O)(=O)N2c3ccccc3CCC2CCS(=O)(=O)N2CCC(NCC3CCCCC3)CC2)c(OC)c1 | 10.1016/j.bmcl.2010.11.061 | ||
| CHEMBL572709 | 404679 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 619 | 11 | 1 | 7 | 4.6 | COc1ccc(S(=O)(=O)N2c3ccccc3CCC2CCS(=O)(=O)N2CCC(NCC3CCCCC3)CC2)c(OC)c1 | 10.1016/j.bmcl.2010.11.061 | ||
| 44572105 | 336967 | 0 | None | None | None | Human | 5.5 | pKi | = | 5.5 | Functional | ChEMBL | 336 | 6 | 0 | 3 | 3.8 | O=C(c1ccc(-c2ccccc2)nc1)N(CC1CC1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL447916 | 336967 | 0 | None | None | None | Human | 5.5 | pKi | = | 5.5 | Functional | ChEMBL | 336 | 6 | 0 | 3 | 3.8 | O=C(c1ccc(-c2ccccc2)nc1)N(CC1CC1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| 44571489 | 375318 | 0 | None | None | None | Human | 5.5 | pKi | = | 5.5 | Functional | ChEMBL | 372 | 6 | 0 | 3 | 4.6 | O=C(c1ccc(-c2ccccc2)nc1)N(Cc1ccccc1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL520595 | 375318 | 0 | None | None | None | Human | 5.5 | pKi | = | 5.5 | Functional | ChEMBL | 372 | 6 | 0 | 3 | 4.6 | O=C(c1ccc(-c2ccccc2)nc1)N(Cc1ccccc1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| 46225117 | 430007 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 401 | 7 | 0 | 8 | 2.7 | COCc1nnc(N2CC(Oc3ccccc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2009.11.097 | ||
| CHEMBL590349 | 430007 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 401 | 7 | 0 | 8 | 2.7 | COCc1nnc(N2CC(Oc3ccccc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2009.11.097 | ||
| 46225050 | 432397 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 365 | 5 | 0 | 7 | 2.9 | COc1ccc(-n2c(C)nnc2N2CC[C@@H](Oc3ccccc3C)C2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| CHEMBL592731 | 432397 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Functional | ChEMBL | 365 | 5 | 0 | 7 | 2.9 | COc1ccc(-n2c(C)nnc2N2CC[C@@H](Oc3ccccc3C)C2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| 16062053 | 387456 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 360 | 5 | 0 | 8 | 3.2 | COc1ccc(-n2c(C)nnc2-c2cnc(Oc3ccccc3)cn2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| CHEMBL539665 | 387456 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 360 | 5 | 0 | 8 | 3.2 | COc1ccc(-n2c(C)nnc2-c2cnc(Oc3ccccc3)cn2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| 46881890 | 22763 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 377 | 5 | 0 | 4 | 3.4 | CCN(C(=O)N1CC(Oc2cc(F)cc(F)c2C)C1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.01.143 | ||
| CHEMBL1093744 | 22763 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 377 | 5 | 0 | 4 | 3.4 | CCN(C(=O)N1CC(Oc2cc(F)cc(F)c2C)C1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.01.143 | ||
| 45272491 | 393499 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 428 | 5 | 0 | 8 | 4.5 | COc1ccc(-n2c(C)nnc2-c2cnc(Oc3ccc(Cl)cc3Cl)cn2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| CHEMBL563613 | 393499 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 428 | 5 | 0 | 8 | 4.5 | COc1ccc(-n2c(C)nnc2-c2cnc(Oc3ccc(Cl)cc3Cl)cn2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| 44572107 | 353814 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 385 | 6 | 0 | 2 | 5.5 | Cc1cc(C(=O)N(Cc2ccccc2)CC2CCCO2)ccc1-c1ccccc1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL474621 | 353814 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 385 | 6 | 0 | 2 | 5.5 | Cc1cc(C(=O)N(Cc2ccccc2)CC2CCCO2)ccc1-c1ccccc1 | 10.1016/j.bmcl.2008.11.064 | ||
| 46884478 | 22804 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 373 | 5 | 0 | 6 | 3.4 | CCN(C(=O)c1cnc(-c2ccc(C#N)cc2C)cn1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1094002 | 22804 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 373 | 5 | 0 | 6 | 3.4 | CCN(C(=O)c1cnc(-c2ccc(C#N)cc2C)cn1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| 53317994 | 119565 | 0 | None | None | None | Human | 5.4 | pKi | = | 5.4 | Functional | ChEMBL | 513 | 11 | 0 | 6 | 5.8 | CCN(CC)Cc1ccc(-c2nc(CN(C3CCCC3)S(=O)(=O)c3ccc(OC)cc3)cs2)cc1 | 10.1016/j.bmcl.2010.11.061 | ||
| CHEMBL1643586 | 119565 | 0 | None | None | None | Human | 5.4 | pKi | = | 5.4 | Functional | ChEMBL | 513 | 11 | 0 | 6 | 5.8 | CCN(CC)Cc1ccc(-c2nc(CN(C3CCCC3)S(=O)(=O)c3ccc(OC)cc3)cs2)cc1 | 10.1016/j.bmcl.2010.11.061 | ||
| 11384094 | 352494 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 402 | 6 | 0 | 8 | 3.6 | COCc1nnc(-c2cnc(-c3cccc(C)c3C)cn2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2008.06.098 | ||
| CHEMBL467186 | 352494 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 402 | 6 | 0 | 8 | 3.6 | COCc1nnc(-c2cnc(-c3cccc(C)c3C)cn2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2008.06.098 | ||
| 15548579 | 221104 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 728 | 11 | 8 | 8 | 1.4 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CCCSC[C@H](CCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@H](C)CC)NC1=O | 10.1016/s0960-894x(99)00478-3 | ||
| CHEMBL328348 | 221104 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 728 | 11 | 8 | 8 | 1.4 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CCCSC[C@H](CCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@H](C)CC)NC1=O | 10.1016/s0960-894x(99)00478-3 | ||
| 11538526 | 432148 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 397 | 5 | 0 | 7 | 3.5 | COc1ccc(-n2c(C)nnc2N2CCC(Oc3ccc(F)cc3C)CC2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| CHEMBL592494 | 432148 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 397 | 5 | 0 | 7 | 3.5 | COc1ccc(-n2c(C)nnc2N2CCC(Oc3ccc(F)cc3C)CC2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| 46225118 | 451494 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 369 | 5 | 0 | 7 | 2.7 | COc1ccc(-n2c(C)nnc2N2CC(Oc3cc(F)ccc3C)C2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| CHEMBL602641 | 451494 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 369 | 5 | 0 | 7 | 2.7 | COc1ccc(-n2c(C)nnc2N2CC(Oc3cc(F)ccc3C)C2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| 46883829 | 22767 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 336 | 5 | 1 | 4 | 3.5 | CCN(C(=O)c1cc(-c2ccc(C)cc2)n[nH]1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1093776 | 22767 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 336 | 5 | 1 | 4 | 3.5 | CCN(C(=O)c1cc(-c2ccc(C)cc2)n[nH]1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| 46881892 | 22471 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 387 | 5 | 0 | 7 | 2.8 | COc1ccc(-n2c(C)nnc2N2CC(Oc3cc(F)cc(F)c3C)C2)cn1 | 10.1016/j.bmcl.2010.01.143 | ||
| CHEMBL1091817 | 22471 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 387 | 5 | 0 | 7 | 2.8 | COc1ccc(-n2c(C)nnc2N2CC(Oc3cc(F)cc(F)c3C)C2)cn1 | 10.1016/j.bmcl.2010.01.143 | ||
| 44577938 | 372442 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 374 | 6 | 0 | 8 | 2.9 | COCc1nnc(-c2cnc(-c3ccccc3)cn2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2008.06.098 | ||
| CHEMBL512257 | 372442 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 374 | 6 | 0 | 8 | 2.9 | COCc1nnc(-c2cnc(-c3ccccc3)cn2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2008.06.098 | ||
| 46844644 | 22812 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 359 | 5 | 0 | 4 | 3.2 | CCN(C(=O)N1CC(Oc2ccc(F)cc2C)C1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.01.143 | ||
| CHEMBL1094050 | 22812 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 359 | 5 | 0 | 4 | 3.2 | CCN(C(=O)N1CC(Oc2ccc(F)cc2C)C1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.01.143 | ||
| 46884479 | 22577 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 403 | 7 | 0 | 7 | 3.0 | COCCN(C(=O)c1cnc(-c2ccc(C#N)cc2C)cn1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1092457 | 22577 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Functional | ChEMBL | 403 | 7 | 0 | 7 | 3.0 | COCCN(C(=O)c1cnc(-c2ccc(C#N)cc2C)cn1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| 44579442 | 370091 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 391 | 7 | 0 | 9 | 2.7 | CCOc1ccc(-c2nnc(Cn3nccn3)n2-c2ccc(OC)nc2)cc1C | 10.1016/j.bmcl.2008.08.066 | ||
| CHEMBL489387 | 370091 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Functional | ChEMBL | 391 | 7 | 0 | 9 | 2.7 | CCOc1ccc(-c2nnc(Cn3nccn3)n2-c2ccc(OC)nc2)cc1C | 10.1016/j.bmcl.2008.08.066 | ||
| 46883887 | 22090 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 336 | 6 | 0 | 4 | 3.7 | CCN(C(=O)COc1ccc2ccccc2c1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1089272 | 22090 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 336 | 6 | 0 | 4 | 3.7 | CCN(C(=O)COc1ccc2ccccc2c1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| 46881891 | 22810 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 379 | 5 | 0 | 4 | 3.6 | CCN(C(=O)N1CC(Oc2ccc(F)cc2Cl)C1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.01.143 | ||
| CHEMBL1094049 | 22810 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 379 | 5 | 0 | 4 | 3.6 | CCN(C(=O)N1CC(Oc2ccc(F)cc2Cl)C1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.01.143 | ||
| 11625088 | 432146 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 379 | 5 | 0 | 7 | 3.3 | COc1ccc(-n2c(C)nnc2N2CCC(Oc3ccccc3C)CC2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| CHEMBL592493 | 432146 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 379 | 5 | 0 | 7 | 3.3 | COc1ccc(-n2c(C)nnc2N2CCC(Oc3ccccc3C)CC2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| 46225081 | 465739 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 431 | 7 | 0 | 8 | 3.1 | COCc1nnc(N2CC[C@@H](Oc3cc(F)cc(F)c3C)C2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2009.11.097 | ||
| CHEMBL609848 | 465739 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 431 | 7 | 0 | 8 | 3.1 | COCc1nnc(N2CC[C@@H](Oc3cc(F)cc(F)c3C)C2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2009.11.097 | ||
| 44186995 | 389894 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 388 | 5 | 0 | 8 | 3.8 | COc1ccc(-n2c(C)nnc2-c2cnc(Oc3c(C)cccc3C)cn2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| CHEMBL550244 | 389894 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 388 | 5 | 0 | 8 | 3.8 | COc1ccc(-n2c(C)nnc2-c2cnc(Oc3c(C)cccc3C)cn2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| 44577874 | 352490 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 376 | 4 | 0 | 6 | 3.6 | CO/N=C1/C[C@H](c2ncno2)N(C(=O)c2ccc(-c3ccccc3C)cc2)C1 | 10.1016/j.bmcl.2008.06.098 | ||
| CHEMBL467153 | 352490 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 376 | 4 | 0 | 6 | 3.6 | CO/N=C1/C[C@H](c2ncno2)N(C(=O)c2ccc(-c3ccccc3C)cc2)C1 | 10.1016/j.bmcl.2008.06.098 | ||
| 4017619 | 354281 | 20 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 335 | 6 | 0 | 2 | 4.4 | O=C(c1ccc(-c2ccccc2)cc1)N(CC1CC1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL475207 | 354281 | 20 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 335 | 6 | 0 | 2 | 4.4 | O=C(c1ccc(-c2ccccc2)cc1)N(CC1CC1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| 50941635 | 119563 | 0 | None | None | None | Human | 5.3 | pKi | = | 5.3 | Functional | ChEMBL | 513 | 12 | 1 | 6 | 5.8 | CCCCNCc1ccc(-c2nc(CN(C3CCCC3)S(=O)(=O)c3ccc(OC)cc3)cs2)cc1 | 10.1016/j.bmcl.2010.11.061 | ||
| CHEMBL1643584 | 119563 | 0 | None | None | None | Human | 5.3 | pKi | = | 5.3 | Functional | ChEMBL | 513 | 12 | 1 | 6 | 5.8 | CCCCNCc1ccc(-c2nc(CN(C3CCCC3)S(=O)(=O)c3ccc(OC)cc3)cs2)cc1 | 10.1016/j.bmcl.2010.11.061 | ||
| 53324622 | 119570 | 0 | None | None | None | Human | 4.3 | pKi | = | 4.3 | Functional | ChEMBL | 577 | 12 | 1 | 7 | 6.3 | COc1ccc(CNCc2ccc(-c3nc(CN(C4CCCC4)S(=O)(=O)c4ccc(OC)cc4)cs3)cc2)cc1 | 10.1016/j.bmcl.2010.11.061 | ||
| CHEMBL1643591 | 119570 | 0 | None | None | None | Human | 4.3 | pKi | = | 4.3 | Functional | ChEMBL | 577 | 12 | 1 | 7 | 6.3 | COc1ccc(CNCc2ccc(-c3nc(CN(C4CCCC4)S(=O)(=O)c4ccc(OC)cc4)cs3)cc2)cc1 | 10.1016/j.bmcl.2010.11.061 | ||
| 45269934 | 390070 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 388 | 6 | 0 | 8 | 3.8 | CCc1ccccc1Oc1cnc(-c2nnc(C)n2-c2ccc(OC)nc2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| CHEMBL551395 | 390070 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 388 | 6 | 0 | 8 | 3.8 | CCc1ccccc1Oc1cnc(-c2nnc(C)n2-c2ccc(OC)nc2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| 44577984 | 372415 | 0 | None | None | None | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 418 | 7 | 0 | 9 | 3.3 | COCc1nnc(-c2cnc(-c3ccc(OC)c(C)c3)cn2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2008.06.098 | ||
| CHEMBL511917 | 372415 | 0 | None | None | None | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 418 | 7 | 0 | 9 | 3.3 | COCc1nnc(-c2cnc(-c3ccc(OC)c(C)c3)cn2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2008.06.098 | ||
| 46225116 | 429762 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 371 | 5 | 0 | 7 | 2.9 | COc1ccc(-n2c(C)nnc2N2CC(Oc3ccccc3Cl)C2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| CHEMBL590099 | 429762 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 371 | 5 | 0 | 7 | 2.9 | COc1ccc(-n2c(C)nnc2N2CC(Oc3ccccc3Cl)C2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| 44577936 | 352492 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 371 | 5 | 0 | 5 | 4.9 | COc1ccc(-n2c(C)nnc2-c2ccc(-c3ccccc3OC)cc2)cc1 | 10.1016/j.bmcl.2008.06.098 | ||
| CHEMBL467184 | 352492 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 371 | 5 | 0 | 5 | 4.9 | COc1ccc(-n2c(C)nnc2-c2ccc(-c3ccccc3OC)cc2)cc1 | 10.1016/j.bmcl.2008.06.098 | ||
| 11257380 | 352525 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 376 | 4 | 0 | 7 | 3.6 | COc1ccc(-n2c(C)nnc2-c2cnc(-c3ccc(F)cc3C)cn2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| CHEMBL467378 | 352525 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 376 | 4 | 0 | 7 | 3.6 | COc1ccc(-n2c(C)nnc2-c2cnc(-c3ccc(F)cc3C)cn2)cn1 | 10.1016/j.bmcl.2009.11.097 | ||
| 11257380 | 352525 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 376 | 4 | 0 | 7 | 3.6 | COc1ccc(-n2c(C)nnc2-c2cnc(-c3ccc(F)cc3C)cn2)cn1 | 10.1016/j.bmcl.2008.06.098 | ||
| CHEMBL467378 | 352525 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 376 | 4 | 0 | 7 | 3.6 | COc1ccc(-n2c(C)nnc2-c2cnc(-c3ccc(F)cc3C)cn2)cn1 | 10.1016/j.bmcl.2008.06.098 | ||
| 11257380 | 352525 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 376 | 4 | 0 | 7 | 3.6 | COc1ccc(-n2c(C)nnc2-c2cnc(-c3ccc(F)cc3C)cn2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| CHEMBL467378 | 352525 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 376 | 4 | 0 | 7 | 3.6 | COc1ccc(-n2c(C)nnc2-c2cnc(-c3ccc(F)cc3C)cn2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| 135461089 | 145109 | 4 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 478 | 8 | 2 | 6 | 4.8 | CCOc1ccc(S(=O)(=O)N(CC(=O)/N=N/c2c(O)[nH]c3ccccc23)c2ccccc2)cc1 | 10.1016/j.bmcl.2008.08.066 | ||
| CHEMBL200403 | 145109 | 4 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 478 | 8 | 2 | 6 | 4.8 | CCOc1ccc(S(=O)(=O)N(CC(=O)/N=N/c2c(O)[nH]c3ccccc23)c2ccccc2)cc1 | 10.1016/j.bmcl.2008.08.066 | ||
| CHEMBL491224 | 145109 | 4 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 478 | 8 | 2 | 6 | 4.8 | CCOc1ccc(S(=O)(=O)N(CC(=O)/N=N/c2c(O)[nH]c3ccccc23)c2ccccc2)cc1 | 10.1016/j.bmcl.2008.08.066 | ||
| 44581240 | 372840 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 486 | 8 | 0 | 7 | 4.4 | COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3C#N)cn2)c2ccc(OC)nc2)cc1 | 10.1016/j.bmcl.2008.11.018 | ||
| CHEMBL515660 | 372840 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 486 | 8 | 0 | 7 | 4.4 | COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3C#N)cn2)c2ccc(OC)nc2)cc1 | 10.1016/j.bmcl.2008.11.018 | ||
| 46884441 | 22719 | 0 | None | None | None | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 359 | 4 | 0 | 6 | 3.0 | COc1ccc(N(C)C(=O)c2cnc(-c3ccc(C#N)cc3C)cn2)cn1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1093367 | 22719 | 0 | None | None | None | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 359 | 4 | 0 | 6 | 3.0 | COc1ccc(N(C)C(=O)c2cnc(-c3ccc(C#N)cc3C)cn2)cn1 | 10.1016/j.bmcl.2010.02.018 | ||
| 44571387 | 367386 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 401 | 7 | 0 | 3 | 5.2 | COc1ccccc1-c1ccc(C(=O)N(Cc2ccccc2)CC2CCCO2)cc1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL482321 | 367386 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 401 | 7 | 0 | 3 | 5.2 | COc1ccccc1-c1ccc(C(=O)N(Cc2ccccc2)CC2CCCO2)cc1 | 10.1016/j.bmcl.2008.11.064 | ||
| 44572045 | 372772 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 365 | 7 | 0 | 3 | 4.4 | COc1ccccc1-c1ccc(C(=O)N(CC2CC2)CC2CCCO2)cc1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL515111 | 372772 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 365 | 7 | 0 | 3 | 4.4 | COc1ccccc1-c1ccc(C(=O)N(CC2CC2)CC2CCCO2)cc1 | 10.1016/j.bmcl.2008.11.064 | ||
| 44572046 | 353486 | 0 | None | None | None | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 413 | 7 | 0 | 4 | 3.8 | CS(=O)(=O)c1ccccc1-c1ccc(C(=O)N(CC2CC2)CC2CCCO2)cc1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL474219 | 353486 | 0 | None | None | None | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 413 | 7 | 0 | 4 | 3.8 | CS(=O)(=O)c1ccccc1-c1ccc(C(=O)N(CC2CC2)CC2CCCO2)cc1 | 10.1016/j.bmcl.2008.11.064 | ||
| 44571388 | 385141 | 0 | None | None | None | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 385 | 6 | 0 | 2 | 5.5 | Cc1cc(-c2ccccc2)ccc1C(=O)N(Cc1ccccc1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL521444 | 385141 | 0 | None | None | None | Human | 6.2 | pKi | = | 6.2 | Functional | ChEMBL | 385 | 6 | 0 | 2 | 5.5 | Cc1cc(-c2ccccc2)ccc1C(=O)N(Cc1ccccc1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| 44571530 | 353800 | 0 | None | None | None | Human | 5.2 | pKi | = | 5.2 | Functional | ChEMBL | 379 | 7 | 0 | 3 | 4.7 | COc1ccc(C)cc1-c1ccc(C(=O)N(CC2CC2)CC2CCCO2)cc1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL474609 | 353800 | 0 | None | None | None | Human | 5.2 | pKi | = | 5.2 | Functional | ChEMBL | 379 | 7 | 0 | 3 | 4.7 | COc1ccc(C)cc1-c1ccc(C(=O)N(CC2CC2)CC2CCCO2)cc1 | 10.1016/j.bmcl.2008.11.064 | ||
| 44571490 | 367270 | 0 | None | None | None | Human | 5.2 | pKi | = | 5.2 | Functional | ChEMBL | 415 | 7 | 0 | 3 | 5.5 | COc1ccc(C)cc1-c1ccc(C(=O)N(Cc2ccccc2)CC2CCCO2)cc1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL481568 | 367270 | 0 | None | None | None | Human | 5.2 | pKi | = | 5.2 | Functional | ChEMBL | 415 | 7 | 0 | 3 | 5.5 | COc1ccc(C)cc1-c1ccc(C(=O)N(Cc2ccccc2)CC2CCCO2)cc1 | 10.1016/j.bmcl.2008.11.064 | ||
| 53323297 | 119567 | 0 | None | None | None | Human | 5.2 | pKi | = | 5.2 | Functional | ChEMBL | 499 | 11 | 1 | 6 | 5.5 | CCCNCc1ccc(-c2nc(CN(C3CCCC3)S(=O)(=O)c3ccc(OC)cc3)cs2)cc1 | 10.1016/j.bmcl.2010.11.061 | ||
| CHEMBL1643588 | 119567 | 0 | None | None | None | Human | 5.2 | pKi | = | 5.2 | Functional | ChEMBL | 499 | 11 | 1 | 6 | 5.5 | CCCNCc1ccc(-c2nc(CN(C3CCCC3)S(=O)(=O)c3ccc(OC)cc3)cs2)cc1 | 10.1016/j.bmcl.2010.11.061 | ||
| 53323298 | 119568 | 0 | None | None | None | Human | 5.2 | pKi | = | 5.2 | Functional | ChEMBL | 553 | 11 | 1 | 6 | 6.6 | COc1ccc(S(=O)(=O)N(Cc2csc(-c3ccc(CNCC4CCCCC4)cc3)n2)C2CCCC2)cc1 | 10.1016/j.bmcl.2010.11.061 | ||
| CHEMBL1643589 | 119568 | 0 | None | None | None | Human | 5.2 | pKi | = | 5.2 | Functional | ChEMBL | 553 | 11 | 1 | 6 | 6.6 | COc1ccc(S(=O)(=O)N(Cc2csc(-c3ccc(CNCC4CCCCC4)cc3)n2)C2CCCC2)cc1 | 10.1016/j.bmcl.2010.11.061 | ||
| 46881862 | 22255 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 365 | 4 | 0 | 4 | 3.2 | COc1ccc(N(C)C(=O)N2CC(Oc3ccc(F)cc3Cl)C2)cn1 | 10.1016/j.bmcl.2010.01.143 | ||
| CHEMBL1090417 | 22255 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Functional | ChEMBL | 365 | 4 | 0 | 4 | 3.2 | COc1ccc(N(C)C(=O)N2CC(Oc3ccc(F)cc3Cl)C2)cn1 | 10.1016/j.bmcl.2010.01.143 | ||
| 44572103 | 353218 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 369 | 6 | 0 | 2 | 5.0 | O=C(c1ccc(-c2cccc(Cl)c2)cc1)N(CC1CC1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL473442 | 353218 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 369 | 6 | 0 | 2 | 5.0 | O=C(c1ccc(-c2cccc(Cl)c2)cc1)N(CC1CC1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| 44581266 | 349398 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 479 | 8 | 0 | 6 | 4.7 | COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3F)cn2)c2ccc(OC)nc2)cc1 | 10.1016/j.bmcl.2008.11.018 | ||
| CHEMBL457544 | 349398 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 479 | 8 | 0 | 6 | 4.7 | COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3F)cn2)c2ccc(OC)nc2)cc1 | 10.1016/j.bmcl.2008.11.018 | ||
| 44572104 | 353219 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 369 | 6 | 0 | 2 | 5.0 | O=C(c1ccc(-c2ccc(Cl)cc2)cc1)N(CC1CC1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL473443 | 353219 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 369 | 6 | 0 | 2 | 5.0 | O=C(c1ccc(-c2ccc(Cl)cc2)cc1)N(CC1CC1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| 44571429 | 367146 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 440 | 6 | 0 | 3 | 5.6 | O=C(c1ccc(-c2ccccc2C(F)(F)F)nc1)N(Cc1ccccc1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| CHEMBL480546 | 367146 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 440 | 6 | 0 | 3 | 5.6 | O=C(c1ccc(-c2ccccc2C(F)(F)F)nc1)N(Cc1ccccc1)CC1CCCO1 | 10.1016/j.bmcl.2008.11.064 | ||
| 10437668 | 155157 | 1 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 554 | 9 | 2 | 7 | 1.5 | Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@@H](N)CCS(C)(=O)=O)C3(C)C)CC1 | 10.1016/j.bmcl.2008.06.098 | ||
| CHEMBL2112903 | 155157 | 1 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 554 | 9 | 2 | 7 | 1.5 | Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@@H](N)CCS(C)(=O)=O)C3(C)C)CC1 | 10.1016/j.bmcl.2008.06.098 | ||
| 45268191 | 393840 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 430 | 5 | 0 | 8 | 4.2 | COc1ccc(-n2c(C)nnc2-c2cnc(Oc3c(F)ccc(F)c3Cl)cn2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| CHEMBL565189 | 393840 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 430 | 5 | 0 | 8 | 4.2 | COc1ccc(-n2c(C)nnc2-c2cnc(Oc3c(F)ccc(F)c3Cl)cn2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| 46883925 | 22759 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 379 | 6 | 1 | 5 | 3.1 | CCN(C(=O)c1ccc(-c2ccc(OC)cc2)[nH]c1=O)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1093709 | 22759 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 379 | 6 | 1 | 5 | 3.1 | CCN(C(=O)c1ccc(-c2ccc(OC)cc2)[nH]c1=O)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| 44577981 | 372427 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 369 | 5 | 0 | 8 | 2.8 | COCc1nnc(-c2cnc(-c3cccc(C#N)c3)cn2)n1-c1cccnc1 | 10.1016/j.bmcl.2008.06.098 | ||
| CHEMBL512105 | 372427 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 369 | 5 | 0 | 8 | 2.8 | COCc1nnc(-c2cnc(-c3cccc(C#N)c3)cn2)n1-c1cccnc1 | 10.1016/j.bmcl.2008.06.098 | ||
| 46883830 | 22012 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 336 | 5 | 0 | 5 | 3.3 | CCN(C(=O)c1cnn(-c2ccccc2)c1C)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1088765 | 22012 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 336 | 5 | 0 | 5 | 3.3 | CCN(C(=O)c1cnn(-c2ccccc2)c1C)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| 46883885 | 22715 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 326 | 5 | 0 | 5 | 3.5 | CCN(C(=O)c1cc2cc(OC)ccc2o1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1093341 | 22715 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 326 | 5 | 0 | 5 | 3.5 | CCN(C(=O)c1cc2cc(OC)ccc2o1)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| 45273367 | 393525 | 0 | None | None | None | Human | 8.0 | pKi | = | 8.0 | Functional | ChEMBL | 392 | 5 | 0 | 8 | 3.7 | COc1ccc(-n2c(C)nnc2-c2cnc(Oc3ccc(F)cc3C)cn2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| CHEMBL563771 | 393525 | 0 | None | None | None | Human | 8.0 | pKi | = | 8.0 | Functional | ChEMBL | 392 | 5 | 0 | 8 | 3.7 | COc1ccc(-n2c(C)nnc2-c2cnc(Oc3ccc(F)cc3C)cn2)cn1 | 10.1016/j.bmcl.2009.03.160 | ||
| 11683187 | 444222 | 42 | None | None | None | Human | 8.0 | pKi | = | 8.0 | Functional | ChEMBL | 419 | 7 | 0 | 8 | 2.9 | COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2009.11.097 | ||
| CHEMBL594828 | 444222 | 42 | None | None | None | Human | 8.0 | pKi | = | 8.0 | Functional | ChEMBL | 419 | 7 | 0 | 8 | 2.9 | COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1016/j.bmcl.2009.11.097 | ||
| 46884413 | 22512 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 318 | 4 | 0 | 3 | 4.0 | COc1ccc(N(C)C(=O)c2ccc(-c3ccccc3)cc2)cn1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1092098 | 22512 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 318 | 4 | 0 | 3 | 4.0 | COc1ccc(N(C)C(=O)c2ccc(-c3ccccc3)cc2)cn1 | 10.1016/j.bmcl.2010.02.018 | ||
| 46883832 | 22014 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 366 | 6 | 0 | 6 | 3.3 | CCN(C(=O)c1cnn(-c2ccc(OC)cc2)c1C)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1088767 | 22014 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 366 | 6 | 0 | 6 | 3.3 | CCN(C(=O)c1cnn(-c2ccc(OC)cc2)c1C)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| 46884414 | 22155 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 334 | 4 | 0 | 5 | 3.1 | COc1ccc(N(C)C(=O)c2cnc(-c3ccccc3C)cn2)cn1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1089682 | 22155 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 334 | 4 | 0 | 5 | 3.1 | COc1ccc(N(C)C(=O)c2cnc(-c3ccccc3C)cn2)cn1 | 10.1016/j.bmcl.2010.02.018 | ||
| 46883888 | 22455 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 349 | 5 | 1 | 4 | 3.1 | CCN(C(=O)c1ccc(-c2ccccc2)[nH]c1=O)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1091770 | 22455 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 349 | 5 | 1 | 4 | 3.1 | CCN(C(=O)c1ccc(-c2ccccc2)[nH]c1=O)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| 46883831 | 22013 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 366 | 7 | 0 | 6 | 2.9 | COCCN(C(=O)c1cnn(-c2ccccc2)c1C)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| CHEMBL1088766 | 22013 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 366 | 7 | 0 | 6 | 2.9 | COCCN(C(=O)c1cnn(-c2ccccc2)c1C)c1ccc(OC)nc1 | 10.1016/j.bmcl.2010.02.018 | ||
| 11169 | 1650 | 39 | None | -10 | 5 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | Guide to Pharmacology | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 30199637 | ||
| 165708555 | 1650 | 39 | None | -10 | 5 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | Guide to Pharmacology | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 30199637 | ||
| 16681432 | 1650 | 39 | None | -10 | 5 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | Guide to Pharmacology | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 30199637 | ||
| 495 | 1650 | 39 | None | -10 | 5 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | Guide to Pharmacology | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 30199637 | ||
| CHEMBL3301668 | 1650 | 39 | None | -10 | 5 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | Guide to Pharmacology | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 30199637 | ||
| DB01282 | 1650 | 39 | None | -10 | 5 | Mouse | 7.2 | pEC50 | = | 7.2 | Functional | Guide to Pharmacology | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 30199637 | ||
| 11169 | 1650 | 39 | None | 1 | 5 | Human | 8.0 | pEC50 | = | 8 | Functional | Guide to Pharmacology | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 30199637 | ||
| 165708555 | 1650 | 39 | None | 1 | 5 | Human | 8.0 | pEC50 | = | 8 | Functional | Guide to Pharmacology | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 30199637 | ||
| 16681432 | 1650 | 39 | None | 1 | 5 | Human | 8.0 | pEC50 | = | 8 | Functional | Guide to Pharmacology | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 30199637 | ||
| 495 | 1650 | 39 | None | 1 | 5 | Human | 8.0 | pEC50 | = | 8 | Functional | Guide to Pharmacology | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 30199637 | ||
| CHEMBL3301668 | 1650 | 39 | None | 1 | 5 | Human | 8.0 | pEC50 | = | 8 | Functional | Guide to Pharmacology | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 30199637 | ||
| DB01282 | 1650 | 39 | None | 1 | 5 | Human | 8.0 | pEC50 | = | 8 | Functional | Guide to Pharmacology | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 30199637 | ||
| 14550 | 3029 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Functional | Guide to Pharmacology | None | None | None | None | None | ||||
| 2255 | 5308 | 0 | None | None | None | Human | 7.1 | pIC50 | None | 7.1 | Functional | Guide to Pharmacology | None | None | None | None | 17316912 | ||||
| 2256 | 5310 | 0 | None | None | None | Human | 7.3 | pIC50 | None | 7.3 | Functional | Guide to Pharmacology | None | None | None | None | 17316912 | ||||
| 2254 | 5312 | 0 | None | None | None | Human | 7.6 | pIC50 | None | 7.6 | Functional | Guide to Pharmacology | None | None | None | None | 17316912 | ||||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Similar- ity |
Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
Assay Type |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 118719819 | 234679 | 0 | None | None | None | Human | 11.0 | pEC50 | = | 11 | Binding | ChEMBL | 1005 | 20 | 11 | 14 | -2.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)CC2CC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353930 | 234679 | 0 | None | None | None | Human | 11.0 | pEC50 | = | 11 | Binding | ChEMBL | 1005 | 20 | 11 | 14 | -2.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)CC2CC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118719821 | 234681 | 0 | None | None | None | Human | 11.0 | pEC50 | = | 11 | Binding | ChEMBL | 1005 | 19 | 11 | 14 | -2.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C2CCC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353932 | 234681 | 0 | None | None | None | Human | 11.0 | pEC50 | = | 11 | Binding | ChEMBL | 1005 | 19 | 11 | 14 | -2.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C2CCC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118719828 | 234688 | 0 | None | None | None | Human | 11.0 | pEC50 | = | 11 | Binding | ChEMBL | 1019 | 19 | 11 | 14 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C2CCCC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353939 | 234688 | 0 | None | None | None | Human | 11.0 | pEC50 | = | 11 | Binding | ChEMBL | 1019 | 19 | 11 | 14 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C2CCCC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118719829 | 234689 | 0 | None | None | None | Human | 11.0 | pEC50 | = | 11 | Binding | ChEMBL | 1035 | 23 | 11 | 14 | -1.1 | CCCCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm500365s | |||
| CHEMBL3353940 | 234689 | 0 | None | None | None | Human | 11.0 | pEC50 | = | 11 | Binding | ChEMBL | 1035 | 23 | 11 | 14 | -1.1 | CCCCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm500365s | |||
| 118719835 | 234695 | 0 | None | None | None | Human | 11.0 | pEC50 | = | 11 | Binding | ChEMBL | 1055 | 20 | 11 | 14 | -1.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccc(C)c2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353946 | 234695 | 0 | None | None | None | Human | 11.0 | pEC50 | = | 11 | Binding | ChEMBL | 1055 | 20 | 11 | 14 | -1.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccc(C)c2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118719837 | 234697 | 0 | None | None | None | Human | 11.0 | pEC50 | = | 11 | Binding | ChEMBL | 1059 | 20 | 11 | 14 | -1.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353948 | 234697 | 0 | None | None | None | Human | 11.0 | pEC50 | = | 11 | Binding | ChEMBL | 1059 | 20 | 11 | 14 | -1.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118719845 | 234705 | 0 | None | None | None | Human | 11.0 | pEC50 | = | 11 | Binding | ChEMBL | 1047 | 20 | 11 | 15 | -1.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccs2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353956 | 234705 | 0 | None | None | None | Human | 11.0 | pEC50 | = | 11 | Binding | ChEMBL | 1047 | 20 | 11 | 15 | -1.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccs2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118720268 | 234776 | 0 | None | None | None | Human | 11.0 | pEC50 | = | 11 | Binding | ChEMBL | 991 | 21 | 12 | 14 | -3.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354579 | 234776 | 0 | None | None | None | Human | 11.0 | pEC50 | = | 11 | Binding | ChEMBL | 991 | 21 | 12 | 14 | -3.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 155560248 | 349072 | 0 | None | None | None | Human | 11.0 | pEC50 | = | 11.0 | Binding | ChEMBL | 2235 | 53 | 24 | 30 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4567752 | 349072 | 0 | None | None | None | Human | 11.0 | pEC50 | = | 11.0 | Binding | ChEMBL | 2235 | 53 | 24 | 30 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 155542264 | 347207 | 0 | None | None | None | Human | 10.9 | pEC50 | = | 10.9 | Binding | ChEMBL | 2151 | 47 | 24 | 30 | -5.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4520170 | 347207 | 0 | None | None | None | Human | 10.9 | pEC50 | = | 10.9 | Binding | ChEMBL | 2151 | 47 | 24 | 30 | -5.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 118719844 | 234704 | 0 | None | None | None | Human | 10.7 | pEC50 | = | 10.7 | Binding | ChEMBL | 1056 | 21 | 11 | 15 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCc2ccncc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353955 | 234704 | 0 | None | None | None | Human | 10.7 | pEC50 | = | 10.7 | Binding | ChEMBL | 1056 | 21 | 11 | 15 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCc2ccncc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118720260 | 234768 | 0 | None | None | None | Human | 10.7 | pEC50 | = | 10.7 | Binding | ChEMBL | 1061 | 21 | 11 | 15 | -1.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCc2cccs2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354571 | 234768 | 0 | None | None | None | Human | 10.7 | pEC50 | = | 10.7 | Binding | ChEMBL | 1061 | 21 | 11 | 15 | -1.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCc2cccs2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118720282 | 234789 | 0 | None | None | None | Human | 10.7 | pEC50 | = | 10.7 | Binding | ChEMBL | 1038 | 20 | 11 | 13 | -1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccc(C)c2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354592 | 234789 | 0 | None | None | None | Human | 10.7 | pEC50 | = | 10.7 | Binding | ChEMBL | 1038 | 20 | 11 | 13 | -1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccc(C)c2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118719831 | 234691 | 0 | None | None | None | Human | 10.5 | pEC50 | = | 10.5 | Binding | ChEMBL | 1009 | 21 | 11 | 15 | -3.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCOC)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353942 | 234691 | 0 | None | None | None | Human | 10.5 | pEC50 | = | 10.5 | Binding | ChEMBL | 1009 | 21 | 11 | 15 | -3.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCOC)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118720278 | 234785 | 0 | None | None | None | Human | 10.4 | pEC50 | = | 10.4 | Binding | ChEMBL | 1023 | 20 | 11 | 13 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354588 | 234785 | 0 | None | None | None | Human | 10.4 | pEC50 | = | 10.4 | Binding | ChEMBL | 1023 | 20 | 11 | 13 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118720284 | 234792 | 0 | None | None | None | Human | 10.4 | pEC50 | = | 10.4 | Binding | ChEMBL | 1041 | 20 | 11 | 13 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354595 | 234792 | 0 | None | None | None | Human | 10.4 | pEC50 | = | 10.4 | Binding | ChEMBL | 1041 | 20 | 11 | 13 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 44232512 | 234794 | 0 | None | None | None | Human | 10.4 | pEC50 | = | 10.4 | Binding | ChEMBL | 1038 | 21 | 11 | 13 | -1.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CCc2ccccc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354597 | 234794 | 0 | None | None | None | Human | 10.4 | pEC50 | = | 10.4 | Binding | ChEMBL | 1038 | 21 | 11 | 13 | -1.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CCc2ccccc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118719818 | 234678 | 0 | None | None | None | Human | 10.3 | pEC50 | = | 10.3 | Binding | ChEMBL | 991 | 19 | 11 | 14 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C2CC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353929 | 234678 | 0 | None | None | None | Human | 10.3 | pEC50 | = | 10.3 | Binding | ChEMBL | 991 | 19 | 11 | 14 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C2CC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118720279 | 234786 | 0 | None | None | None | Human | 10.3 | pEC50 | = | 10.3 | Binding | ChEMBL | 1023 | 20 | 11 | 13 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354589 | 234786 | 0 | None | None | None | Human | 10.3 | pEC50 | = | 10.3 | Binding | ChEMBL | 1023 | 20 | 11 | 13 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118720286 | 234795 | 0 | None | None | None | Human | 10.3 | pEC50 | = | 10.3 | Binding | ChEMBL | 1038 | 21 | 11 | 13 | -1.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CCc2ccccc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354598 | 234795 | 0 | None | None | None | Human | 10.3 | pEC50 | = | 10.3 | Binding | ChEMBL | 1038 | 21 | 11 | 13 | -1.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CCc2ccccc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 171345673 | 386814 | 0 | None | None | None | Human | 10.2 | pEC50 | = | 10.2 | Binding | ChEMBL | 1221 | 21 | 18 | 21 | -9.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CCC(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)NC(C)(C)C(=O)NCC(=O)N[C@@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acsmedchemlett.2c00455 | |||
| CHEMBL5286119 | 386814 | 0 | None | None | None | Human | 10.2 | pEC50 | = | 10.2 | Binding | ChEMBL | 1221 | 21 | 18 | 21 | -9.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CCC(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)NC(C)(C)C(=O)NCC(=O)N[C@@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acsmedchemlett.2c00455 | |||
| 118719820 | 234680 | 0 | None | None | None | Human | 10.2 | pEC50 | = | 10.2 | Binding | ChEMBL | 1007 | 21 | 11 | 14 | -1.9 | CCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm500365s | |||
| CHEMBL3353931 | 234680 | 0 | None | None | None | Human | 10.2 | pEC50 | = | 10.2 | Binding | ChEMBL | 1007 | 21 | 11 | 14 | -1.9 | CCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm500365s | |||
| 118719824 | 234684 | 0 | None | None | None | Human | 10.2 | pEC50 | = | 10.2 | Binding | ChEMBL | 1017 | 19 | 11 | 14 | -3.1 | CCOc1ccc(C[C@@H]2NC(=O)CCCSC[C@@H](C(=O)N3C[C@@H](O)C[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1021/jm500365s | |||
| CHEMBL3353935 | 234684 | 0 | None | None | None | Human | 10.2 | pEC50 | = | 10.2 | Binding | ChEMBL | 1017 | 19 | 11 | 14 | -3.1 | CCOc1ccc(C[C@@H]2NC(=O)CCCSC[C@@H](C(=O)N3C[C@@H](O)C[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1021/jm500365s | |||
| 118719838 | 234698 | 0 | None | None | None | Human | 10.2 | pEC50 | = | 10.2 | Binding | ChEMBL | 1071 | 21 | 11 | 15 | -1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(OC)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353949 | 234698 | 0 | None | None | None | Human | 10.2 | pEC50 | = | 10.2 | Binding | ChEMBL | 1071 | 21 | 11 | 15 | -1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(OC)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118720261 | 234769 | 0 | None | None | None | Human | 10.2 | pEC50 | = | 10.2 | Binding | ChEMBL | 1035 | 20 | 11 | 15 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)CC2CCCO2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354572 | 234769 | 0 | None | None | None | Human | 10.2 | pEC50 | = | 10.2 | Binding | ChEMBL | 1035 | 20 | 11 | 15 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)CC2CCCO2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118720277 | 234784 | 0 | None | None | None | Human | 10.2 | pEC50 | = | 10.2 | Binding | ChEMBL | 988 | 22 | 10 | 12 | -1.5 | CCCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CCSCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm500365s | |||
| CHEMBL3354587 | 234784 | 0 | None | None | None | Human | 10.2 | pEC50 | = | 10.2 | Binding | ChEMBL | 988 | 22 | 10 | 12 | -1.5 | CCCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CCSCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm500365s | |||
| 118720281 | 234788 | 0 | None | None | None | Human | 10.1 | pEC50 | = | 10.1 | Binding | ChEMBL | 1038 | 20 | 11 | 13 | -1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccc(C)c2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354591 | 234788 | 0 | None | None | None | Human | 10.1 | pEC50 | = | 10.1 | Binding | ChEMBL | 1038 | 20 | 11 | 13 | -1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccc(C)c2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 76073634 | 234791 | 7 | None | None | None | Human | 10.1 | pEC50 | = | 10.1 | Binding | ChEMBL | 1041 | 20 | 11 | 13 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354594 | 234791 | 7 | None | None | None | Human | 10.1 | pEC50 | = | 10.1 | Binding | ChEMBL | 1041 | 20 | 11 | 13 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| DB12932 | 234791 | 7 | None | None | None | Human | 10.1 | pEC50 | = | 10.1 | Binding | ChEMBL | 1041 | 20 | 11 | 13 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118720274 | 234781 | 0 | None | None | None | Human | 10.1 | pEC50 | = | 10.1 | Binding | ChEMBL | 974 | 21 | 10 | 12 | -1.9 | CCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CCSCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm500365s | |||
| CHEMBL3354584 | 234781 | 0 | None | None | None | Human | 10.1 | pEC50 | = | 10.1 | Binding | ChEMBL | 974 | 21 | 10 | 12 | -1.9 | CCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CCSCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm500365s | |||
| 118720288 | 234797 | 0 | None | None | None | Human | 10.1 | pEC50 | = | 10.1 | Binding | ChEMBL | 1029 | 20 | 11 | 14 | -1.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccs2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354600 | 234797 | 0 | None | None | None | Human | 10.1 | pEC50 | = | 10.1 | Binding | ChEMBL | 1029 | 20 | 11 | 14 | -1.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccs2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 449224 | 333602 | 12 | None | None | None | Human | 10.0 | pEC50 | = | 10 | Binding | ChEMBL | 991 | 17 | 11 | 14 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL439044 | 333602 | 12 | None | None | None | Human | 10.0 | pEC50 | = | 10 | Binding | ChEMBL | 991 | 17 | 11 | 14 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| DB13798 | 333602 | 12 | None | None | None | Human | 10.0 | pEC50 | = | 10 | Binding | ChEMBL | 991 | 17 | 11 | 14 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118719833 | 234693 | 0 | None | None | None | Human | 10.0 | pEC50 | = | 10.0 | Binding | ChEMBL | 1041 | 20 | 11 | 14 | -1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353944 | 234693 | 0 | None | None | None | Human | 10.0 | pEC50 | = | 10.0 | Binding | ChEMBL | 1041 | 20 | 11 | 14 | -1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118720259 | 234767 | 0 | None | None | None | Human | 10.0 | pEC50 | = | 10.0 | Binding | ChEMBL | 1031 | 20 | 11 | 15 | -1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccco2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354570 | 234767 | 0 | None | None | None | Human | 10.0 | pEC50 | = | 10.0 | Binding | ChEMBL | 1031 | 20 | 11 | 15 | -1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccco2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118720264 | 234772 | 0 | None | None | None | Human | 10.0 | pEC50 | = | 10.0 | Binding | ChEMBL | 991 | 21 | 11 | 14 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CCOC)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354575 | 234772 | 0 | None | None | None | Human | 10.0 | pEC50 | = | 10.0 | Binding | ChEMBL | 991 | 21 | 11 | 14 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CCOC)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118720275 | 234782 | 0 | None | None | None | Human | 10.0 | pEC50 | = | 10.0 | Binding | ChEMBL | 1004 | 22 | 11 | 13 | -1.8 | CCCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm500365s | |||
| CHEMBL3354585 | 234782 | 0 | None | None | None | Human | 10.0 | pEC50 | = | 10.0 | Binding | ChEMBL | 1004 | 22 | 11 | 13 | -1.8 | CCCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm500365s | |||
| 118719834 | 234694 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Binding | ChEMBL | 1055 | 20 | 11 | 14 | -1.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccc2C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353945 | 234694 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Binding | ChEMBL | 1055 | 20 | 11 | 14 | -1.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccc2C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118719842 | 234702 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Binding | ChEMBL | 1055 | 21 | 11 | 14 | -1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCc2ccccc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353953 | 234702 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Binding | ChEMBL | 1055 | 21 | 11 | 14 | -1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCc2ccccc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118719843 | 234703 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Binding | ChEMBL | 1056 | 21 | 11 | 15 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCc2ccccn2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353954 | 234703 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Binding | ChEMBL | 1056 | 21 | 11 | 15 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCc2ccccn2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118720271 | 234778 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Binding | ChEMBL | 990 | 21 | 11 | 13 | -2.2 | CCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm500365s | |||
| CHEMBL3354581 | 234778 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Binding | ChEMBL | 990 | 21 | 11 | 13 | -2.2 | CCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm500365s | |||
| 118719827 | 234687 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Binding | ChEMBL | 1021 | 22 | 11 | 14 | -1.5 | CCCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm500365s | |||
| CHEMBL3353938 | 234687 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Binding | ChEMBL | 1021 | 22 | 11 | 14 | -1.5 | CCCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm500365s | |||
| 118720269 | 234777 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Binding | ChEMBL | 991 | 21 | 12 | 14 | -3.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354580 | 234777 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Binding | ChEMBL | 991 | 21 | 12 | 14 | -3.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118720272 | 234779 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Binding | ChEMBL | 990 | 21 | 11 | 13 | -2.2 | CCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CCSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm500365s | |||
| CHEMBL3354582 | 234779 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Binding | ChEMBL | 990 | 21 | 11 | 13 | -2.2 | CCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CCSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm500365s | |||
| 118720289 | 234798 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Binding | ChEMBL | 1029 | 20 | 11 | 14 | -1.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccs2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354601 | 234798 | 0 | None | None | None | Human | 9.9 | pEC50 | = | 9.9 | Binding | ChEMBL | 1029 | 20 | 11 | 14 | -1.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccs2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118719836 | 234696 | 0 | None | None | None | Human | 9.8 | pEC50 | = | 9.8 | Binding | ChEMBL | 1055 | 20 | 11 | 14 | -1.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(C)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353947 | 234696 | 0 | None | None | None | Human | 9.8 | pEC50 | = | 9.8 | Binding | ChEMBL | 1055 | 20 | 11 | 14 | -1.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(C)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118720265 | 234773 | 0 | None | None | None | Human | 9.8 | pEC50 | = | 9.8 | Binding | ChEMBL | 991 | 21 | 11 | 14 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CCOC)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354576 | 234773 | 0 | None | None | None | Human | 9.8 | pEC50 | = | 9.8 | Binding | ChEMBL | 991 | 21 | 11 | 14 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N(CCOC)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118719825 | 234685 | 0 | None | None | None | Human | 9.7 | pEC50 | = | 9.7 | Binding | ChEMBL | 1032 | 20 | 10 | 14 | -2.5 | CCOc1ccc(C[C@@H]2NC(=O)CCCSC[C@@H](C(=O)N3C[C@@H](OC)C[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1021/jm500365s | |||
| CHEMBL3353936 | 234685 | 0 | None | None | None | Human | 9.7 | pEC50 | = | 9.7 | Binding | ChEMBL | 1032 | 20 | 10 | 14 | -2.5 | CCOc1ccc(C[C@@H]2NC(=O)CCCSC[C@@H](C(=O)N3C[C@@H](OC)C[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1021/jm500365s | |||
| 118720273 | 234780 | 0 | None | None | None | Human | 9.6 | pEC50 | = | 9.6 | Binding | ChEMBL | 974 | 21 | 10 | 12 | -1.9 | CCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm500365s | |||
| CHEMBL3354583 | 234780 | 0 | None | None | None | Human | 9.6 | pEC50 | = | 9.6 | Binding | ChEMBL | 974 | 21 | 10 | 12 | -1.9 | CCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm500365s | |||
| 118720285 | 234793 | 0 | None | None | None | Human | 9.6 | pEC50 | = | 9.6 | Binding | ChEMBL | 1025 | 20 | 10 | 12 | -1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354596 | 234793 | 0 | None | None | None | Human | 9.6 | pEC50 | = | 9.6 | Binding | ChEMBL | 1025 | 20 | 10 | 12 | -1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118720276 | 234783 | 0 | None | None | None | Human | 9.6 | pEC50 | = | 9.6 | Binding | ChEMBL | 1004 | 22 | 11 | 13 | -1.8 | CCCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CCSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm500365s | |||
| CHEMBL3354586 | 234783 | 0 | None | None | None | Human | 9.6 | pEC50 | = | 9.6 | Binding | ChEMBL | 1004 | 22 | 11 | 13 | -1.8 | CCCCCN(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(=O)[C@@H]1CCSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm500365s | |||
| 155559767 | 348923 | 1 | None | None | None | Human | 9.6 | pEC50 | = | 9.6 | Binding | ChEMBL | 1006 | 19 | 12 | 15 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4564152 | 348923 | 1 | None | None | None | Human | 9.6 | pEC50 | = | 9.6 | Binding | ChEMBL | 1006 | 19 | 12 | 15 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 171357037 | 386541 | 0 | None | None | None | Human | 9.6 | pEC50 | = | 9.6 | Binding | ChEMBL | 1150 | 19 | 17 | 20 | -8.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CC(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)NC(C)(C)C(=O)N[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acsmedchemlett.2c00455 | |||
| CHEMBL5280014 | 386541 | 0 | None | None | None | Human | 9.6 | pEC50 | = | 9.6 | Binding | ChEMBL | 1150 | 19 | 17 | 20 | -8.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CC(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)NC(C)(C)C(=O)N[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acsmedchemlett.2c00455 | |||
| 118720290 | 234799 | 0 | None | None | None | Human | 9.5 | pEC50 | = | 9.5 | Binding | ChEMBL | 1013 | 20 | 10 | 13 | -1.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccs2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354602 | 234799 | 0 | None | None | None | Human | 9.5 | pEC50 | = | 9.5 | Binding | ChEMBL | 1013 | 20 | 10 | 13 | -1.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccs2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118719826 | 234686 | 0 | None | None | None | Human | 9.4 | pEC50 | = | 9.4 | Binding | ChEMBL | 947 | 19 | 11 | 13 | -3.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353937 | 234686 | 0 | None | None | None | Human | 9.4 | pEC50 | = | 9.4 | Binding | ChEMBL | 947 | 19 | 11 | 13 | -3.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118719832 | 234692 | 0 | None | None | None | Human | 9.4 | pEC50 | = | 9.4 | Binding | ChEMBL | 1009 | 21 | 12 | 15 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353943 | 234692 | 0 | None | None | None | Human | 9.4 | pEC50 | = | 9.4 | Binding | ChEMBL | 1009 | 21 | 12 | 15 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118720280 | 234787 | 0 | None | None | None | Human | 9.4 | pEC50 | = | 9.4 | Binding | ChEMBL | 1007 | 20 | 10 | 12 | -1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354590 | 234787 | 0 | None | None | None | Human | 9.4 | pEC50 | = | 9.4 | Binding | ChEMBL | 1007 | 20 | 10 | 12 | -1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118719841 | 234701 | 0 | None | None | None | Human | 9.3 | pEC50 | = | 9.3 | Binding | ChEMBL | 1042 | 20 | 11 | 15 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccncc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353952 | 234701 | 0 | None | None | None | Human | 9.3 | pEC50 | = | 9.3 | Binding | ChEMBL | 1042 | 20 | 11 | 15 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccncc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 171347098 | 386267 | 0 | None | None | None | Human | 9.3 | pEC50 | = | 9.3 | Binding | ChEMBL | 1340 | 24 | 20 | 25 | -10.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CC(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acsmedchemlett.2c00455 | |||
| CHEMBL5273426 | 386267 | 0 | None | None | None | Human | 9.3 | pEC50 | = | 9.3 | Binding | ChEMBL | 1340 | 24 | 20 | 25 | -10.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CC(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acsmedchemlett.2c00455 | |||
| 118720283 | 234790 | 0 | None | None | None | Human | 9.3 | pEC50 | = | 9.3 | Binding | ChEMBL | 1022 | 20 | 10 | 12 | -1.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccc(C)c2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354593 | 234790 | 0 | None | None | None | Human | 9.3 | pEC50 | = | 9.3 | Binding | ChEMBL | 1022 | 20 | 10 | 12 | -1.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccc(C)c2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 11169 | 1650 | 39 | None | None | None | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/jm500365s | |||
| 165708555 | 1650 | 39 | None | None | None | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/jm500365s | |||
| 16681432 | 1650 | 39 | None | None | None | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/jm500365s | |||
| 495 | 1650 | 39 | None | None | None | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/jm500365s | |||
| CHEMBL3301668 | 1650 | 39 | None | None | None | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/jm500365s | |||
| DB01282 | 1650 | 39 | None | None | None | Human | 9.2 | pEC50 | = | 9.2 | Binding | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/jm500365s | |||
| 171352228 | 386359 | 0 | None | None | None | Human | 9.1 | pEC50 | = | 9.1 | Binding | ChEMBL | 1192 | 21 | 17 | 20 | -7.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CCC(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acsmedchemlett.2c00455 | |||
| CHEMBL5275543 | 386359 | 0 | None | None | None | Human | 9.1 | pEC50 | = | 9.1 | Binding | ChEMBL | 1192 | 21 | 17 | 20 | -7.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CCC(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acsmedchemlett.2c00455 | |||
| 155559767 | 348923 | 1 | None | None | None | Human | 9.1 | pEC50 | = | 9.1 | Binding | ChEMBL | 1006 | 19 | 12 | 15 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4564152 | 348923 | 1 | None | None | None | Human | 9.1 | pEC50 | = | 9.1 | Binding | ChEMBL | 1006 | 19 | 12 | 15 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 118720287 | 234796 | 0 | None | None | None | Human | 9.1 | pEC50 | = | 9.1 | Binding | ChEMBL | 1022 | 21 | 10 | 12 | -1.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CCc2ccccc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354599 | 234796 | 0 | None | None | None | Human | 9.1 | pEC50 | = | 9.1 | Binding | ChEMBL | 1022 | 21 | 10 | 12 | -1.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CCc2ccccc2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118719823 | 234683 | 0 | None | None | None | Human | 9.1 | pEC50 | = | 9.1 | Binding | ChEMBL | 1033 | 19 | 10 | 14 | -2.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCCSC[C@@H](C(=O)N2C[C@H](SC)C[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353934 | 234683 | 0 | None | None | None | Human | 9.1 | pEC50 | = | 9.1 | Binding | ChEMBL | 1033 | 19 | 10 | 14 | -2.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCCSC[C@@H](C(=O)N2C[C@H](SC)C[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118720267 | 234775 | 0 | None | None | None | Human | 9.1 | pEC50 | = | 9.1 | Binding | ChEMBL | 975 | 21 | 10 | 13 | -3.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CCOC)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354578 | 234775 | 0 | None | None | None | Human | 9.1 | pEC50 | = | 9.1 | Binding | ChEMBL | 975 | 21 | 10 | 13 | -3.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CCOC)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118720270 | 234452 | 0 | None | None | None | Human | 9.1 | pEC50 | = | 9.1 | Binding | ChEMBL | 975 | 21 | 11 | 13 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3352839 | 234452 | 0 | None | None | None | Human | 9.1 | pEC50 | = | 9.1 | Binding | ChEMBL | 975 | 21 | 11 | 13 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSCC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 155559767 | 348923 | 1 | None | None | None | Human | 9.0 | pEC50 | = | 9.0 | Binding | ChEMBL | 1006 | 19 | 12 | 15 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4564152 | 348923 | 1 | None | None | None | Human | 9.0 | pEC50 | = | 9.0 | Binding | ChEMBL | 1006 | 19 | 12 | 15 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 118720266 | 234774 | 0 | None | None | None | Human | 9.0 | pEC50 | = | 9.0 | Binding | ChEMBL | 975 | 21 | 10 | 13 | -3.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCSC[C@@H](C(=O)N(CCOC)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354577 | 234774 | 0 | None | None | None | Human | 9.0 | pEC50 | = | 9.0 | Binding | ChEMBL | 975 | 21 | 10 | 13 | -3.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCSC[C@@H](C(=O)N(CCOC)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118719822 | 234682 | 0 | None | None | None | Human | 9.0 | pEC50 | = | 9.0 | Binding | ChEMBL | 1017 | 19 | 10 | 14 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCCSC[C@@H](C(=O)N2C[C@H](OC)C[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353933 | 234682 | 0 | None | None | None | Human | 9.0 | pEC50 | = | 9.0 | Binding | ChEMBL | 1017 | 19 | 10 | 14 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCCSC[C@@H](C(=O)N2C[C@H](OC)C[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 2042 | 8014 | 41 | None | None | None | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.9b01862 | |||
| 2176 | 8014 | 41 | None | None | None | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.9b01862 | |||
| 439302 | 8014 | 41 | None | None | None | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.9b01862 | |||
| CHEMBL395429 | 8014 | 41 | None | None | None | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.9b01862 | |||
| 118719830 | 234690 | 0 | None | None | None | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 1033 | 19 | 11 | 14 | -1.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C2CCCCC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353941 | 234690 | 0 | None | None | None | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 1033 | 19 | 11 | 14 | -1.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C2CCCCC2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118719839 | 234699 | 0 | None | None | None | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 1042 | 20 | 11 | 15 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccn2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353950 | 234699 | 0 | None | None | None | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 1042 | 20 | 11 | 15 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccccn2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118719840 | 234700 | 0 | None | None | None | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 1042 | 20 | 11 | 15 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccnc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3353951 | 234700 | 0 | None | None | None | Human | 8.9 | pEC50 | = | 8.9 | Binding | ChEMBL | 1042 | 20 | 11 | 15 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2cccnc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 118720263 | 234771 | 0 | None | None | None | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 1064 | 21 | 11 | 16 | -3.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCN2CCOCC2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354574 | 234771 | 0 | None | None | None | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 1064 | 21 | 11 | 16 | -3.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCN2CCOCC2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 155515303 | 334552 | 0 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 1336 | 41 | 13 | 18 | -0.7 | CCCCCCCCCCCCCC(=O)NCCOCCOCCNC(=O)CSC[C@H](NC(=O)CNC(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)N(C)CC(N)=O | 10.1021/acs.jmedchem.9b01862 | |||
| CHEMBL4442222 | 334552 | 0 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 1336 | 41 | 13 | 18 | -0.7 | CCCCCCCCCCCCCC(=O)NCCOCCOCCNC(=O)CSC[C@H](NC(=O)CNC(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)N(C)CC(N)=O | 10.1021/acs.jmedchem.9b01862 | |||
| 155551252 | 348013 | 0 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 2179 | 49 | 24 | 30 | -4.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4541104 | 348013 | 0 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 2179 | 49 | 24 | 30 | -4.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 155553462 | 348194 | 0 | None | None | None | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 2123 | 45 | 24 | 30 | -6.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4546103 | 348194 | 0 | None | None | None | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 2123 | 45 | 24 | 30 | -6.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 5311065 | 484177 | 30 | None | None | None | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/acs.jmedchem.9b00132 | |||
| 817 | 484177 | 30 | None | None | None | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/acs.jmedchem.9b00132 | |||
| CHEMBL1429 | 484177 | 30 | None | None | None | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/acs.jmedchem.9b00132 | |||
| DB00035 | 484177 | 30 | None | None | None | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/acs.jmedchem.9b00132 | |||
| 155542264 | 347207 | 0 | None | None | None | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 2151 | 47 | 24 | 30 | -5.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4520170 | 347207 | 0 | None | None | None | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 2151 | 47 | 24 | 30 | -5.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 3537 | 8682 | 25 | None | None | None | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 402 | 2 | 0 | 4 | 4.8 | Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 | 10.1021/jm901084f | |||
| 5311500 | 8682 | 25 | None | None | None | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 402 | 2 | 0 | 4 | 4.8 | Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 | 10.1021/jm901084f | |||
| CHEMBL363910 | 8682 | 25 | None | None | None | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 402 | 2 | 0 | 4 | 4.8 | Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 | 10.1021/jm901084f | |||
| 155551252 | 348013 | 0 | None | None | None | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 2179 | 49 | 24 | 30 | -4.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4541104 | 348013 | 0 | None | None | None | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 2179 | 49 | 24 | 30 | -4.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 155542151 | 347209 | 0 | None | None | None | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 2207 | 51 | 24 | 30 | -3.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4520203 | 347209 | 0 | None | None | None | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 2207 | 51 | 24 | 30 | -3.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 155542151 | 347209 | 0 | None | None | None | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 2207 | 51 | 24 | 30 | -3.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4520203 | 347209 | 0 | None | None | None | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 2207 | 51 | 24 | 30 | -3.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 155555256 | 348386 | 0 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 1005 | 18 | 11 | 14 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CSCC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b01862 | |||
| CHEMBL4550811 | 348386 | 0 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 1005 | 18 | 11 | 14 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CSCC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b01862 | |||
| 118476348 | 347615 | 0 | None | None | None | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 1096 | 17 | 11 | 13 | 0.6 | CC(C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CSC[C@H]2C(=O)N[C@H](CCCNC(=N)N)C(=O)NCc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b00132 | |||
| CHEMBL4531053 | 347615 | 0 | None | None | None | Human | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 1096 | 17 | 11 | 13 | 0.6 | CC(C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CSC[C@H]2C(=O)N[C@H](CCCNC(=N)N)C(=O)NCc2ccccc2)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b00132 | |||
| 2042 | 8014 | 41 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm100989w | |||
| 2176 | 8014 | 41 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm100989w | |||
| 439302 | 8014 | 41 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm100989w | |||
| CHEMBL395429 | 8014 | 41 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm100989w | |||
| 155560248 | 349072 | 0 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 2235 | 53 | 24 | 30 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4567752 | 349072 | 0 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 2235 | 53 | 24 | 30 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 44393941 | 335393 | 0 | None | None | None | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 595 | 8 | 2 | 6 | 4.4 | CO[C@@H]1C[C@@H](C(=O)NCCc2ccccn2)N(C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)C1 | 10.1016/j.bmcl.2004.04.107 | |||
| CHEMBL445393 | 335393 | 0 | None | None | None | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 595 | 8 | 2 | 6 | 4.4 | CO[C@@H]1C[C@@H](C(=O)NCCc2ccccn2)N(C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)C1 | 10.1016/j.bmcl.2004.04.107 | |||
| 53317550 | 119139 | 0 | None | None | None | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 1026 | 17 | 12 | 14 | -3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CS[Se]C[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| CHEMBL1630523 | 119139 | 0 | None | None | None | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 1026 | 17 | 12 | 14 | -3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CS[Se]C[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| 171357008 | 386523 | 0 | None | None | None | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 1397 | 26 | 21 | 26 | -11.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CC(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO[C@@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acsmedchemlett.2c00455 | |||
| CHEMBL5279634 | 386523 | 0 | None | None | None | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 1397 | 26 | 21 | 26 | -11.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CC(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO[C@@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acsmedchemlett.2c00455 | |||
| 155523986 | 335455 | 0 | None | None | None | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 957 | 15 | 12 | 13 | -1.5 | CC(C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CO)CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b00132 | |||
| CHEMBL4454891 | 335455 | 0 | None | None | None | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 957 | 15 | 12 | 13 | -1.5 | CC(C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CO)CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b00132 | |||
| 155551252 | 348013 | 0 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 2179 | 49 | 24 | 30 | -4.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4541104 | 348013 | 0 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 2179 | 49 | 24 | 30 | -4.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 155552392 | 348214 | 0 | None | None | None | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 1452 | 49 | 15 | 20 | -0.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCOCCNC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b01862 | |||
| CHEMBL4546597 | 348214 | 0 | None | None | None | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 1452 | 49 | 15 | 20 | -0.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCOCCNC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b01862 | |||
| 53320505 | 119140 | 0 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 1074 | 17 | 12 | 13 | -4.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)C[Se][Se]C[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| CHEMBL1630524 | 119140 | 0 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 1074 | 17 | 12 | 13 | -4.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)C[Se][Se]C[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| 155553492 | 348195 | 0 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1322 | 41 | 14 | 18 | -1.0 | CCCCCCCCCCCCCC(=O)NCCOCCOCCNC(=O)CSC[C@H](NC(=O)CNC(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/acs.jmedchem.9b01862 | |||
| CHEMBL4546106 | 348195 | 0 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1322 | 41 | 14 | 18 | -1.0 | CCCCCCCCCCCCCC(=O)NCCOCCOCCNC(=O)CSC[C@H](NC(=O)CNC(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/acs.jmedchem.9b01862 | |||
| 155542151 | 347209 | 0 | None | None | None | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 2207 | 51 | 24 | 30 | -3.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4520203 | 347209 | 0 | None | None | None | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 2207 | 51 | 24 | 30 | -3.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 118720262 | 234770 | 0 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1048 | 21 | 12 | 15 | -2.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCC2CCCN2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| CHEMBL3354573 | 234770 | 0 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1048 | 21 | 12 | 15 | -2.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N(CCC2CCCN2)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm500365s | |||
| 155542264 | 347207 | 0 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 2151 | 47 | 24 | 30 | -5.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4520170 | 347207 | 0 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 2151 | 47 | 24 | 30 | -5.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 155548766 | 347846 | 0 | None | None | None | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 1724 | 62 | 18 | 24 | -0.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCC(=O)NCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b01862 | |||
| CHEMBL4537162 | 347846 | 0 | None | None | None | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 1724 | 62 | 18 | 24 | -0.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCC(=O)NCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b01862 | |||
| 2042 | 8014 | 41 | None | None | None | Human | 8.7 | pEC50 | = | 8.7 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.6b00564 | |||
| 2176 | 8014 | 41 | None | None | None | Human | 8.7 | pEC50 | = | 8.7 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.6b00564 | |||
| 439302 | 8014 | 41 | None | None | None | Human | 8.7 | pEC50 | = | 8.7 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL395429 | 8014 | 41 | None | None | None | Human | 8.7 | pEC50 | = | 8.7 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.6b00564 | |||
| 2042 | 8014 | 41 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.9b01862 | |||
| 2176 | 8014 | 41 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.9b01862 | |||
| 439302 | 8014 | 41 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.9b01862 | |||
| CHEMBL395429 | 8014 | 41 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.9b01862 | |||
| 2042 | 8014 | 41 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acsmedchemlett.2c00455 | |||
| 2176 | 8014 | 41 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acsmedchemlett.2c00455 | |||
| 439302 | 8014 | 41 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acsmedchemlett.2c00455 | |||
| CHEMBL395429 | 8014 | 41 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acsmedchemlett.2c00455 | |||
| 2042 | 8014 | 41 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm500365s | |||
| 2176 | 8014 | 41 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm500365s | |||
| 439302 | 8014 | 41 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm500365s | |||
| CHEMBL395429 | 8014 | 41 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm500365s | |||
| 155548766 | 347846 | 0 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 1724 | 62 | 18 | 24 | -0.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCC(=O)NCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b01862 | |||
| CHEMBL4537162 | 347846 | 0 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 1724 | 62 | 18 | 24 | -0.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCC(=O)NCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b01862 | |||
| 53316559 | 119138 | 0 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 1026 | 17 | 12 | 14 | -3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)C[Se]SC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| CHEMBL1630522 | 119138 | 0 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 1026 | 17 | 12 | 14 | -3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)C[Se]SC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| 155559767 | 348923 | 1 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 1006 | 19 | 12 | 15 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4564152 | 348923 | 1 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Binding | ChEMBL | 1006 | 19 | 12 | 15 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 11169 | 1650 | 39 | None | None | None | Human | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.9b01862 | |||
| 165708555 | 1650 | 39 | None | None | None | Human | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.9b01862 | |||
| 16681432 | 1650 | 39 | None | None | None | Human | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.9b01862 | |||
| 495 | 1650 | 39 | None | None | None | Human | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.9b01862 | |||
| CHEMBL3301668 | 1650 | 39 | None | None | None | Human | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.9b01862 | |||
| DB01282 | 1650 | 39 | None | None | None | Human | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.9b01862 | |||
| 155542151 | 347209 | 0 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 2207 | 51 | 24 | 30 | -3.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4520203 | 347209 | 0 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 2207 | 51 | 24 | 30 | -3.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 155551252 | 348013 | 0 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 2179 | 49 | 24 | 30 | -4.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4541104 | 348013 | 0 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 2179 | 49 | 24 | 30 | -4.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 155553462 | 348194 | 0 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 2123 | 45 | 24 | 30 | -6.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4546103 | 348194 | 0 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 2123 | 45 | 24 | 30 | -6.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 146681949 | 8624 | 35 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm500365s | |||
| 2168 | 8624 | 35 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm500365s | |||
| 2810 | 8624 | 35 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm500365s | |||
| 644077 | 8624 | 35 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm500365s | |||
| CHEMBL373742 | 8624 | 35 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm500365s | |||
| DB00067 | 8624 | 35 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm500365s | |||
| P01185 | 8624 | 35 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm500365s | |||
| P01186 | 8624 | 35 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm500365s | |||
| P35455 | 8624 | 35 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm500365s | |||
| 171344442 | 386179 | 0 | None | None | None | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 1164 | 19 | 17 | 20 | -8.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CCC(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)NC(C)(C)C(=O)N[C@@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acsmedchemlett.2c00455 | |||
| CHEMBL5271164 | 386179 | 0 | None | None | None | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 1164 | 19 | 17 | 20 | -8.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CCC(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)NC(C)(C)C(=O)N[C@@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acsmedchemlett.2c00455 | |||
| 44394045 | 334075 | 0 | None | None | None | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 641 | 6 | 1 | 6 | 5.2 | CO[C@@H]1C[C@@H](C(=O)N2CCC(N3CCCCC3)CC2)N(C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)C1 | 10.1016/j.bmcl.2004.04.107 | |||
| CHEMBL443300 | 334075 | 0 | None | None | None | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 641 | 6 | 1 | 6 | 5.2 | CO[C@@H]1C[C@@H](C(=O)N2CCC(N3CCCCC3)CC2)N(C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)C1 | 10.1016/j.bmcl.2004.04.107 | |||
| 118476338 | 347488 | 0 | None | None | None | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 957 | 15 | 12 | 13 | -1.5 | CC(C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](CO)CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b00132 | |||
| CHEMBL4528032 | 347488 | 0 | None | None | None | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 957 | 15 | 12 | 13 | -1.5 | CC(C)[C@@H]1NC(=O)[C@H](Cc2cccs2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@H](CO)CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b00132 | |||
| 10282736 | 251877 | 0 | None | None | None | Human | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 627 | 6 | 1 | 6 | 4.8 | CO[C@@H]1C[C@@H](C(=O)N2CCC(N3CCCC3)CC2)N(C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)C1 | 10.1016/j.bmcl.2004.04.107 | |||
| CHEMBL362382 | 251877 | 0 | None | None | None | Human | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 627 | 6 | 1 | 6 | 4.8 | CO[C@@H]1C[C@@H](C(=O)N2CCC(N3CCCC3)CC2)N(C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)C1 | 10.1016/j.bmcl.2004.04.107 | |||
| 155553462 | 348194 | 0 | None | None | None | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 2123 | 45 | 24 | 30 | -6.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4546103 | 348194 | 0 | None | None | None | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 2123 | 45 | 24 | 30 | -6.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 53319051 | 119141 | 0 | None | None | None | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 1174 | 17 | 12 | 13 | -4.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)C[Te][Te]C[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| CHEMBL1630525 | 119141 | 0 | None | None | None | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 1174 | 17 | 12 | 13 | -4.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)C[Te][Te]C[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| 44393965 | 254175 | 0 | None | None | None | Human | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 587 | 5 | 1 | 6 | 3.8 | CO[C@@H]1C[C@@H](C(=O)N2CCCN(C)CC2)N(C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)C1 | 10.1016/j.bmcl.2004.04.107 | |||
| CHEMBL364994 | 254175 | 0 | None | None | None | Human | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 587 | 5 | 1 | 6 | 3.8 | CO[C@@H]1C[C@@H](C(=O)N2CCCN(C)CC2)N(C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)C1 | 10.1016/j.bmcl.2004.04.107 | |||
| 155560248 | 349072 | 0 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 2235 | 53 | 24 | 30 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4567752 | 349072 | 0 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 2235 | 53 | 24 | 30 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 155552392 | 348214 | 0 | None | None | None | Human | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 1452 | 49 | 15 | 20 | -0.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCOCCNC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b01862 | |||
| CHEMBL4546597 | 348214 | 0 | None | None | None | Human | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 1452 | 49 | 15 | 20 | -0.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCOCCNC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b01862 | |||
| 155560248 | 349072 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 2235 | 53 | 24 | 30 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4567752 | 349072 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 2235 | 53 | 24 | 30 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 73346893 | 180194 | 0 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 989 | 17 | 12 | 14 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](N)CCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| CHEMBL2369425 | 180194 | 0 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 989 | 17 | 12 | 14 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](N)CCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| 135413563 | 241495 | 20 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 600 | 4 | 2 | 7 | 4.3 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1 | 10.1021/jm901084f | |||
| CHEMBL360648 | 241495 | 20 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 600 | 4 | 2 | 7 | 4.3 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1 | 10.1021/jm901084f | |||
| 135413563 | 241495 | 20 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 600 | 4 | 2 | 7 | 4.3 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1 | 10.1016/j.bmcl.2004.04.107 | |||
| CHEMBL360648 | 241495 | 20 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 600 | 4 | 2 | 7 | 4.3 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1 | 10.1016/j.bmcl.2004.04.107 | |||
| 155559767 | 348923 | 1 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 1006 | 19 | 12 | 15 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4564152 | 348923 | 1 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 1006 | 19 | 12 | 15 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 155542264 | 347207 | 0 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 2151 | 47 | 24 | 30 | -5.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4520170 | 347207 | 0 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 2151 | 47 | 24 | 30 | -5.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 44419025 | 175267 | 18 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 1039 | 17 | 13 | 14 | -2.7 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b00132 | |||
| 44419026 | 175267 | 18 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 1039 | 17 | 13 | 14 | -2.7 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b00132 | |||
| 74992363 | 175267 | 18 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 1039 | 17 | 13 | 14 | -2.7 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b00132 | |||
| CHEMBL221436 | 175267 | 18 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 1039 | 17 | 13 | 14 | -2.7 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b00132 | |||
| CHEMBL435323 | 175267 | 18 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 1039 | 17 | 13 | 14 | -2.7 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b00132 | |||
| CHEMBL6015151 | 175267 | 18 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 1039 | 17 | 13 | 14 | -2.7 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b00132 | |||
| 155542151 | 347209 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 2207 | 51 | 24 | 30 | -3.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4520203 | 347209 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 2207 | 51 | 24 | 30 | -3.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 171355737 | 386627 | 0 | None | None | None | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 985 | 17 | 13 | 14 | -5.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CC(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acsmedchemlett.2c00455 | |||
| CHEMBL5281925 | 386627 | 0 | None | None | None | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 985 | 17 | 13 | 14 | -5.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CC(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acsmedchemlett.2c00455 | |||
| 155559767 | 348923 | 1 | None | None | None | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 1006 | 19 | 12 | 15 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4564152 | 348923 | 1 | None | None | None | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 1006 | 19 | 12 | 15 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 155547725 | 347659 | 0 | None | None | None | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 1133 | 26 | 12 | 15 | -0.9 | CCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4532537 | 347659 | 0 | None | None | None | Human | 8.4 | pEC50 | = | 8.4 | Binding | ChEMBL | 1133 | 26 | 12 | 15 | -0.9 | CCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/acs.jmedchem.6b00564 | |||
| 2252 | 4546 | 39 | None | None | None | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1021/jm901084f | |||
| 6918320 | 4546 | 39 | None | None | None | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1021/jm901084f | |||
| CHEMBL24781 | 4546 | 39 | None | None | None | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1021/jm901084f | |||
| 155527834 | 335829 | 0 | None | None | None | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 1020 | 19 | 12 | 15 | -4.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CSCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b01862 | |||
| CHEMBL4460622 | 335829 | 0 | None | None | None | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 1020 | 19 | 12 | 15 | -4.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CSCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b01862 | |||
| 155542264 | 347207 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 2151 | 47 | 24 | 30 | -5.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4520170 | 347207 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 2151 | 47 | 24 | 30 | -5.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 155551252 | 348013 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 2179 | 49 | 24 | 30 | -4.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4541104 | 348013 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 2179 | 49 | 24 | 30 | -4.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 146681949 | 8624 | 35 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm100989w | |||
| 2168 | 8624 | 35 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm100989w | |||
| 2810 | 8624 | 35 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm100989w | |||
| 644077 | 8624 | 35 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm100989w | |||
| CHEMBL373742 | 8624 | 35 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm100989w | |||
| DB00067 | 8624 | 35 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm100989w | |||
| P01185 | 8624 | 35 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm100989w | |||
| P01186 | 8624 | 35 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm100989w | |||
| P35455 | 8624 | 35 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm100989w | |||
| 44394044 | 251895 | 0 | None | None | None | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 603 | 5 | 1 | 6 | 4.6 | CO[C@@H]1C[C@@H](C(=S)N2CCCN(C)CC2)N(C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)C1 | 10.1016/j.bmcl.2004.04.107 | |||
| CHEMBL362483 | 251895 | 0 | None | None | None | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 603 | 5 | 1 | 6 | 4.6 | CO[C@@H]1C[C@@H](C(=S)N2CCCN(C)CC2)N(C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)C1 | 10.1016/j.bmcl.2004.04.107 | |||
| 155524463 | 335557 | 0 | None | None | None | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 1738 | 62 | 17 | 24 | -0.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCC(=O)NCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b01862 | |||
| CHEMBL4456573 | 335557 | 0 | None | None | None | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 1738 | 62 | 17 | 24 | -0.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCC(=O)NCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b01862 | |||
| 44393911 | 137526 | 0 | None | None | None | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 611 | 8 | 2 | 6 | 5.7 | CO[C@@H]1C[C@@H](/C(S)=N/CCc2ccccn2)N(C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)C1 | 10.1016/j.bmcl.2004.04.107 | |||
| CHEMBL182627 | 137526 | 0 | None | None | None | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 611 | 8 | 2 | 6 | 5.7 | CO[C@@H]1C[C@@H](/C(S)=N/CCc2ccccn2)N(C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)C1 | 10.1016/j.bmcl.2004.04.107 | |||
| 44393912 | 136872 | 0 | None | None | None | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 643 | 6 | 1 | 6 | 5.6 | CO[C@@H]1C[C@@H](C(=S)N2CCC(N3CCCC3)CC2)N(C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)C1 | 10.1016/j.bmcl.2004.04.107 | |||
| CHEMBL181487 | 136872 | 0 | None | None | None | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 643 | 6 | 1 | 6 | 5.6 | CO[C@@H]1C[C@@H](C(=S)N2CCC(N3CCCC3)CC2)N(C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)C1 | 10.1016/j.bmcl.2004.04.107 | |||
| 155553492 | 348195 | 0 | None | None | None | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 1322 | 41 | 14 | 18 | -1.0 | CCCCCCCCCCCCCC(=O)NCCOCCOCCNC(=O)CSC[C@H](NC(=O)CNC(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/acs.jmedchem.9b01862 | |||
| CHEMBL4546106 | 348195 | 0 | None | None | None | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 1322 | 41 | 14 | 18 | -1.0 | CCCCCCCCCCCCCC(=O)NCCOCCOCCNC(=O)CSC[C@H](NC(=O)CNC(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/acs.jmedchem.9b01862 | |||
| 155529697 | 335981 | 0 | None | None | None | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 1362 | 40 | 13 | 18 | -0.2 | CCCCCCCCCCCCCC(=O)NCCOCCOCCNC(=O)CSC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/acs.jmedchem.9b01862 | |||
| CHEMBL4463103 | 335981 | 0 | None | None | None | Human | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 1362 | 40 | 13 | 18 | -0.2 | CCCCCCCCCCCCCC(=O)NCCOCCOCCNC(=O)CSC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/acs.jmedchem.9b01862 | |||
| 155558494 | 348777 | 0 | None | None | None | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 1466 | 49 | 14 | 20 | -0.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCOCCNC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b01862 | |||
| CHEMBL4560445 | 348777 | 0 | None | None | None | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 1466 | 49 | 14 | 20 | -0.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCOCCNC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b01862 | |||
| 155515303 | 334552 | 0 | None | None | None | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 1336 | 41 | 13 | 18 | -0.7 | CCCCCCCCCCCCCC(=O)NCCOCCOCCNC(=O)CSC[C@H](NC(=O)CNC(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)N(C)CC(N)=O | 10.1021/acs.jmedchem.9b01862 | |||
| CHEMBL4442222 | 334552 | 0 | None | None | None | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 1336 | 41 | 13 | 18 | -0.7 | CCCCCCCCCCCCCC(=O)NCCOCCOCCNC(=O)CSC[C@H](NC(=O)CNC(=O)[C@@H]1CSCCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)N(C)CC(N)=O | 10.1021/acs.jmedchem.9b01862 | |||
| 155560248 | 349072 | 0 | None | None | None | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 2235 | 53 | 24 | 30 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4567752 | 349072 | 0 | None | None | None | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 2235 | 53 | 24 | 30 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 10411308 | 462175 | 0 | None | None | None | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 446 | 4 | 1 | 2 | 6.6 | O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1-c1ccccc1 | 10.1021/jm901084f | |||
| CHEMBL603708 | 462175 | 0 | None | None | None | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 446 | 4 | 1 | 2 | 6.6 | O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1-c1ccccc1 | 10.1021/jm901084f | |||
| 10187625 | 255252 | 0 | None | None | None | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 553 | 4 | 1 | 5 | 4.7 | Cc1cc(C(=O)N2CCCCc3sccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1 | 10.1016/j.bmcl.2004.04.107 | |||
| CHEMBL365862 | 255252 | 0 | None | None | None | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 553 | 4 | 1 | 5 | 4.7 | Cc1cc(C(=O)N2CCCCc3sccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1 | 10.1016/j.bmcl.2004.04.107 | |||
| 155524463 | 335557 | 0 | None | None | None | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 1738 | 62 | 17 | 24 | -0.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCC(=O)NCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b01862 | |||
| CHEMBL4456573 | 335557 | 0 | None | None | None | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 1738 | 62 | 17 | 24 | -0.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCC(=O)NCCOCCOCCC(=O)NCCCC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)O)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b01862 | |||
| 155542264 | 347207 | 0 | None | None | None | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 2151 | 47 | 24 | 30 | -5.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4520170 | 347207 | 0 | None | None | None | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 2151 | 47 | 24 | 30 | -5.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 171349253 | 386006 | 0 | None | None | None | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 1000 | 17 | 13 | 14 | -5.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CCC(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acsmedchemlett.2c00455 | |||
| CHEMBL5266871 | 386006 | 0 | None | None | None | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 1000 | 17 | 13 | 14 | -5.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CCC(=O)NC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acsmedchemlett.2c00455 | |||
| 5311065 | 484177 | 30 | None | None | None | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm500365s | |||
| 817 | 484177 | 30 | None | None | None | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm500365s | |||
| CHEMBL1429 | 484177 | 30 | None | None | None | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm500365s | |||
| DB00035 | 484177 | 30 | None | None | None | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm500365s | |||
| 155559767 | 348923 | 1 | None | None | None | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 1006 | 19 | 12 | 15 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4564152 | 348923 | 1 | None | None | None | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 1006 | 19 | 12 | 15 | -3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 44394063 | 138653 | 0 | None | None | None | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 573 | 4 | 1 | 5 | 5.0 | CN1CCCN(C(=S)[C@@H]2CCCN2C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)CC1 | 10.1016/j.bmcl.2004.04.107 | |||
| CHEMBL185152 | 138653 | 0 | None | None | None | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 573 | 4 | 1 | 5 | 5.0 | CN1CCCN(C(=S)[C@@H]2CCCN2C(=O)NCc2ccc(C(=O)N3CCCCc4sccc43)cc2Cl)CC1 | 10.1016/j.bmcl.2004.04.107 | |||
| 155558494 | 348777 | 0 | None | None | None | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 1466 | 49 | 14 | 20 | -0.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCOCCNC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b01862 | |||
| CHEMBL4560445 | 348777 | 0 | None | None | None | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 1466 | 49 | 14 | 20 | -0.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)NCC(=O)N[C@@H](CSCC(=O)NCCOCCOCCOCCNC(=O)CCCCCCCCCCCCCCCCC(=O)O)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.9b01862 | |||
| 155560248 | 349072 | 0 | None | None | None | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 2235 | 53 | 24 | 30 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| CHEMBL4567752 | 349072 | 0 | None | None | None | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 2235 | 53 | 24 | 30 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCCCC(=O)NCCCC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H]2CSSCCC(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2)C(=O)NCC(N)=O)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.6b00564 | |||
| 135506374 | 275287 | 21 | None | None | None | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1016/j.bmcl.2017.04.030 | |||
| CHEMBL3763342 | 275287 | 21 | None | None | None | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1016/j.bmcl.2017.04.030 | |||
| 2042 | 8014 | 41 | None | None | None | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmcl.2017.04.030 | |||
| 2176 | 8014 | 41 | None | None | None | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmcl.2017.04.030 | |||
| 439302 | 8014 | 41 | None | None | None | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmcl.2017.04.030 | |||
| CHEMBL395429 | 8014 | 41 | None | None | None | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmcl.2017.04.030 | |||
| 44352184 | 235844 | 0 | None | None | None | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 687 | 11 | 2 | 8 | 2.5 | Cn1cnc(CC(=O)NC(CCS(C)(=O)=O)C(=O)N[C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)c1 | 10.1021/jm00077a002 | |||
| CHEMBL338711 | 235844 | 0 | None | None | None | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 687 | 11 | 2 | 8 | 2.5 | Cn1cnc(CC(=O)NC(CCS(C)(=O)=O)C(=O)N[C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)c1 | 10.1021/jm00077a002 | |||
| 44352185 | 45253 | 0 | None | None | None | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 673 | 11 | 3 | 7 | 2.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(CCS(C)(=O)=O)NC(=O)Cc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL131477 | 45253 | 0 | None | None | None | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 673 | 11 | 3 | 7 | 2.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(CCS(C)(=O)=O)NC(=O)Cc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| 14981580 | 160371 | 0 | None | None | None | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 637 | 11 | 3 | 8 | 1.9 | Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)NC2CCNCC2)C3(C)C)CC1 | 10.1021/jm00031a004 | |||
| CHEMBL2112895 | 160371 | 0 | None | None | None | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 637 | 11 | 3 | 8 | 1.9 | Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)NC2CCNCC2)C3(C)C)CC1 | 10.1021/jm00031a004 | |||
| 14981581 | 160369 | 0 | None | None | None | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 686 | 11 | 2 | 9 | 1.7 | Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)NC2CCS(=O)(=O)CC2)C3(C)C)CC1 | 10.1021/jm00031a004 | |||
| CHEMBL2112893 | 160369 | 0 | None | None | None | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 686 | 11 | 2 | 9 | 1.7 | Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)NC2CCS(=O)(=O)CC2)C3(C)C)CC1 | 10.1021/jm00031a004 | |||
| 10394512 | 235879 | 0 | None | None | None | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 652 | 11 | 3 | 7 | 2.3 | Cn1cnc(CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)c1 | 10.1021/jm00077a002 | |||
| CHEMBL338921 | 235879 | 0 | None | None | None | Rat | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 652 | 11 | 3 | 7 | 2.3 | Cn1cnc(CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)c1 | 10.1021/jm00077a002 | |||
| CHEMBL2112247 | 485095 | 0 | None | None | None | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 769 | 6 | 4 | 8 | 2.0 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 44273425 | 199139 | 0 | None | None | None | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 557 | 7 | 2 | 6 | 2.6 | C[C@@H](O)CNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL279281 | 199139 | 0 | None | None | None | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 557 | 7 | 2 | 6 | 2.6 | C[C@@H](O)CNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| 44352453 | 42824 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 535 | 6 | 2 | 5 | 3.8 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)c1cccnc1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL128726 | 42824 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 535 | 6 | 2 | 5 | 3.8 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)c1cccnc1)C2 | 10.1021/jm00077a002 | |||
| 10073512 | 44390 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 471 | 4 | 1 | 3 | 3.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1CCNC1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL130768 | 44390 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 471 | 4 | 1 | 3 | 3.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1CCNC1=O)C2 | 10.1021/jm00077a002 | |||
| 10393719 | 46153 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 595 | 8 | 2 | 5 | 4.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)CC1CN3CCC1CC3)C2 | 10.1021/jm00077a002 | |||
| CHEMBL132391 | 46153 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 595 | 8 | 2 | 5 | 4.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)CC1CN3CCC1CC3)C2 | 10.1021/jm00077a002 | |||
| 44352490 | 236785 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 577 | 6 | 2 | 6 | 2.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C1CC(S(C)(=O)=O)CN1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL340362 | 236785 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 577 | 6 | 2 | 6 | 2.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C1CC(S(C)(=O)=O)CN1)C2 | 10.1021/jm00077a002 | |||
| 44433367 | 180676 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 489 | 3 | 1 | 3 | 5.0 | Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CC3C=CC(=O)N3Cc3ccccc32)c(Cl)c1 | 10.1016/j.bmcl.2007.08.053 | |||
| CHEMBL237772 | 180676 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 489 | 3 | 1 | 3 | 5.0 | Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2CC3C=CC(=O)N3Cc3ccccc32)c(Cl)c1 | 10.1016/j.bmcl.2007.08.053 | |||
| 44433372 | 180754 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 426 | 5 | 3 | 3 | 5.0 | Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)Nc2ccccc2C(=O)O)c(Cl)c1 | 10.1016/j.bmcl.2007.08.053 | |||
| CHEMBL237987 | 180754 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 426 | 5 | 3 | 3 | 5.0 | Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)Nc2ccccc2C(=O)O)c(Cl)c1 | 10.1016/j.bmcl.2007.08.053 | |||
| 44433375 | 181015 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 505 | 7 | 3 | 4 | 5.8 | Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)Nc2ccccc2Cn2cccc2C(=O)O)c(Cl)c1 | 10.1016/j.bmcl.2007.08.053 | |||
| CHEMBL238206 | 181015 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 505 | 7 | 3 | 4 | 5.8 | Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)Nc2ccccc2Cn2cccc2C(=O)O)c(Cl)c1 | 10.1016/j.bmcl.2007.08.053 | |||
| 44433363 | 293356 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 489 | 3 | 1 | 3 | 5.7 | Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2C=C3CCC(=O)N3Cc3ccccc32)c(Cl)c1 | 10.1016/j.bmcl.2007.08.053 | |||
| CHEMBL392363 | 293356 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 489 | 3 | 1 | 3 | 5.7 | Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2C=C3CCC(=O)N3Cc3ccccc32)c(Cl)c1 | 10.1016/j.bmcl.2007.08.053 | |||
| 44350917 | 41945 | 0 | None | None | None | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 417 | 3 | 1 | 3 | 3.9 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCCc4ccccc43)CC1)[C@@H](O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL126709 | 41945 | 0 | None | None | None | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 417 | 3 | 1 | 3 | 3.9 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCCc4ccccc43)CC1)[C@@H](O)C2 | 10.1021/jm00099a020 | |||
| 10256140 | 45363 | 0 | None | None | None | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 520 | 6 | 1 | 3 | 4.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@H](NC(=O)Cc1ccccc1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL131613 | 45363 | 0 | None | None | None | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 520 | 6 | 1 | 3 | 4.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@H](NC(=O)Cc1ccccc1)C2 | 10.1021/jm00077a002 | |||
| 11755934 | 236944 | 0 | None | None | None | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 506 | 5 | 1 | 3 | 4.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)c1ccccc1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL340772 | 236944 | 0 | None | None | None | Rat | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 506 | 5 | 1 | 3 | 4.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)c1ccccc1)C2 | 10.1021/jm00077a002 | |||
| 44351224 | 236849 | 0 | None | None | None | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 351 | 3 | 0 | 2 | 4.0 | O=S(=O)(/C=C/c1ccccc1)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| CHEMBL340383 | 236849 | 0 | None | None | None | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 351 | 3 | 0 | 2 | 4.0 | O=S(=O)(/C=C/c1ccccc1)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| 10358978 | 40829 | 0 | None | None | None | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 325 | 2 | 0 | 2 | 3.4 | O=S(=O)(c1ccccc1)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| CHEMBL125358 | 40829 | 0 | None | None | None | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 325 | 2 | 0 | 2 | 3.4 | O=S(=O)(c1ccccc1)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| 9996817 | 41962 | 0 | None | None | None | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 331 | 2 | 0 | 3 | 3.5 | O=S(=O)(c1cccs1)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| CHEMBL126796 | 41962 | 0 | None | None | None | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 331 | 2 | 0 | 3 | 3.5 | O=S(=O)(c1cccs1)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| 19908315 | 42234 | 0 | None | None | None | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 362 | 1 | 1 | 1 | 4.6 | O=C(NC1C2CC3CC(C2)CC1C3)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| CHEMBL127119 | 42234 | 0 | None | None | None | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 362 | 1 | 1 | 1 | 4.6 | O=C(NC1C2CC3CC(C2)CC1C3)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| 11778918 | 43269 | 0 | None | None | None | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 289 | 1 | 0 | 1 | 3.9 | O=C(c1ccccc1)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| CHEMBL129413 | 43269 | 0 | None | None | None | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 289 | 1 | 0 | 1 | 3.9 | O=C(c1ccccc1)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| 10402786 | 235714 | 0 | None | None | None | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 304 | 1 | 1 | 1 | 4.3 | O=C(Nc1ccccc1)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| CHEMBL337976 | 235714 | 0 | None | None | None | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 304 | 1 | 1 | 1 | 4.3 | O=C(Nc1ccccc1)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| 10404941 | 235821 | 0 | None | None | None | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 339 | 2 | 0 | 2 | 3.7 | Cc1ccccc1S(=O)(=O)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| CHEMBL338605 | 235821 | 0 | None | None | None | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 339 | 2 | 0 | 2 | 3.7 | Cc1ccccc1S(=O)(=O)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| 10403606 | 236556 | 0 | None | None | None | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 318 | 1 | 1 | 1 | 4.6 | Cc1ccc(NC(=O)N2CCC3(C=Cc4ccccc43)CC2)cc1 | 10.1021/jm00099a020 | |||
| CHEMBL340149 | 236556 | 0 | None | None | None | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 318 | 1 | 1 | 1 | 4.6 | Cc1ccc(NC(=O)N2CCC3(C=Cc4ccccc43)CC2)cc1 | 10.1021/jm00099a020 | |||
| 10432863 | 193666 | 0 | None | None | None | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 430 | 4 | 2 | 4 | 2.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@](O)(CN)C2 | 10.1021/jm00077a002 | |||
| CHEMBL274955 | 193666 | 0 | None | None | None | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 430 | 4 | 2 | 4 | 2.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@](O)(CN)C2 | 10.1021/jm00077a002 | |||
| 10391626 | 232078 | 0 | None | None | None | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 510 | 6 | 2 | 4 | 3.6 | CC1(C)[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL338362 | 232078 | 0 | None | None | None | Rat | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 510 | 6 | 2 | 4 | 3.6 | CC1(C)[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| 44429299 | 333850 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 1035 | 20 | 11 | 14 | -1.3 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | |||
| CHEMBL441128 | 333850 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 1035 | 20 | 11 | 14 | -1.3 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | |||
| 16737617 | 197207 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 1053 | 17 | 11 | 14 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | |||
| 16737618 | 197207 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 1053 | 17 | 11 | 14 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | |||
| CHEMBL265630 | 197207 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 1053 | 17 | 11 | 14 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | |||
| CHEMBL415418 | 197207 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 1053 | 17 | 11 | 14 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | |||
| 10483940 | 236124 | 0 | None | None | None | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 616 | 9 | 2 | 6 | 3.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(CCS(C)(=O)=O)c1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL339497 | 236124 | 0 | None | None | None | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 616 | 9 | 2 | 6 | 3.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(CCS(C)(=O)=O)c1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| 10368075 | 333140 | 0 | None | None | None | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 484 | 4 | 0 | 4 | 3.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CCC1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL435019 | 333140 | 0 | None | None | None | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 484 | 4 | 0 | 4 | 3.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CCC1=O)C2 | 10.1021/jm00077a002 | |||
| 44352360 | 42727 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 512 | 5 | 1 | 5 | 3.1 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CN1C(=O)CCC1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL128216 | 42727 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 512 | 5 | 1 | 5 | 3.1 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CN1C(=O)CCC1=O)C2 | 10.1021/jm00077a002 | |||
| 44352425 | 44871 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 501 | 6 | 2 | 4 | 3.6 | CC(C)[C@@H](N)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL131168 | 44871 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 501 | 6 | 2 | 4 | 3.6 | CC(C)[C@@H](N)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| 44352371 | 45175 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 593 | 9 | 3 | 7 | 1.8 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)C(N)CCS(C)(=O)=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL131388 | 45175 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 593 | 9 | 3 | 7 | 1.8 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)C(N)CCS(C)(=O)=O)C2 | 10.1021/jm00077a002 | |||
| 44352438 | 234204 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 541 | 6 | 3 | 5 | 3.1 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)C1CCCNC1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL334610 | 234204 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 541 | 6 | 3 | 5 | 3.1 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)C1CCCNC1)C2 | 10.1021/jm00077a002 | |||
| 9985844 | 235551 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 588 | 6 | 2 | 4 | 4.3 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1[nH]cnc1Br)C2 | 10.1021/jm00077a002 | |||
| CHEMBL336992 | 235551 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 588 | 6 | 2 | 4 | 4.3 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1[nH]cnc1Br)C2 | 10.1021/jm00077a002 | |||
| 10099421 | 329796 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 563 | 8 | 2 | 5 | 4.1 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)Cc1ccncc1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL422080 | 329796 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 563 | 8 | 2 | 5 | 4.1 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)Cc1ccncc1)C2 | 10.1021/jm00077a002 | |||
| 44350931 | 41946 | 0 | None | None | None | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 415 | 3 | 0 | 3 | 4.1 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCCc4ccccc43)CC1)C(=O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL126717 | 41946 | 0 | None | None | None | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 415 | 3 | 0 | 3 | 4.1 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCCc4ccccc43)CC1)C(=O)C2 | 10.1021/jm00099a020 | |||
| 44351066 | 43243 | 0 | None | None | None | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 401 | 3 | 0 | 3 | 3.7 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C(=O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL129268 | 43243 | 0 | None | None | None | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 401 | 3 | 0 | 3 | 3.7 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C(=O)C2 | 10.1021/jm00099a020 | |||
| 132072820 | 354798 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 610 | 8 | 0 | 7 | 5.4 | COC(=O)[C@H]1[C@@H](OCc2cccc(OC)c2)CC[C@H]2CN3CC[C@@]4(C(=O)N(Cc5cccc(OC)c5)c5ccccc54)[C@@H]3C[C@@H]21 | 10.1016/j.bmc.2020.115546 | |||
| CHEMBL4758081 | 354798 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 610 | 8 | 0 | 7 | 5.4 | COC(=O)[C@H]1[C@@H](OCc2cccc(OC)c2)CC[C@H]2CN3CC[C@@]4(C(=O)N(Cc5cccc(OC)c5)c5ccccc54)[C@@H]3C[C@@H]21 | 10.1016/j.bmc.2020.115546 | |||
| 71458039 | 155156 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 530 | 8 | 3 | 5 | 2.2 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@@H](N)CCC(N)=O)C2 | 10.1021/jm00031a004 | |||
| CHEMBL2112899 | 155156 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 530 | 8 | 3 | 5 | 2.2 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@@H](N)CCC(N)=O)C2 | 10.1021/jm00031a004 | |||
| 71449109 | 160378 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 565 | 8 | 2 | 6 | 2.4 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@@H](N)CCS(C)(=O)=O)C2 | 10.1021/jm00031a004 | |||
| CHEMBL2112902 | 160378 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 565 | 8 | 2 | 6 | 2.4 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@@H](N)CCS(C)(=O)=O)C2 | 10.1021/jm00031a004 | |||
| 44272997 | 143949 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 499 | 4 | 1 | 5 | 2.6 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@H](N)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| 9805972 | 143949 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 499 | 4 | 1 | 5 | 2.6 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@H](N)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL19658 | 143949 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 499 | 4 | 1 | 5 | 2.6 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@H](N)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL276990 | 143949 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 499 | 4 | 1 | 5 | 2.6 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@H](N)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| 10075696 | 44357 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 530 | 8 | 3 | 5 | 2.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](N)CCC(N)=O)C2 | 10.1021/jm00077a002 | |||
| 10256467 | 44357 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 530 | 8 | 3 | 5 | 2.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](N)CCC(N)=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL130742 | 44357 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 530 | 8 | 3 | 5 | 2.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](N)CCC(N)=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL131650 | 44357 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 530 | 8 | 3 | 5 | 2.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](N)CCC(N)=O)C2 | 10.1021/jm00077a002 | |||
| 10257352 | 160035 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 565 | 8 | 2 | 6 | 2.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](N)CCS(C)(=O)=O)C2 | 10.1021/jm00077a002 | |||
| 10483039 | 160035 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 565 | 8 | 2 | 6 | 2.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](N)CCS(C)(=O)=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL2111851 | 160035 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 565 | 8 | 2 | 6 | 2.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](N)CCS(C)(=O)=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL2112666 | 160035 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 565 | 8 | 2 | 6 | 2.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](N)CCS(C)(=O)=O)C2 | 10.1021/jm00077a002 | |||
| 10370697 | 237189 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 565 | 6 | 1 | 5 | 3.7 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CN(Cc3c[nH]cn3)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL341049 | 237189 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 565 | 6 | 1 | 5 | 3.7 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CN(Cc3c[nH]cn3)C1=O)C2 | 10.1021/jm00077a002 | |||
| 11756081 | 42758 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 510 | 6 | 1 | 5 | 3.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cn1ccnc1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL128398 | 42758 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 510 | 6 | 1 | 5 | 3.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cn1ccnc1)C2 | 10.1021/jm00077a002 | |||
| 10436744 | 45019 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 521 | 6 | 1 | 4 | 4.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1ccncc1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL131269 | 45019 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 521 | 6 | 1 | 4 | 4.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1ccncc1)C2 | 10.1021/jm00077a002 | |||
| 10415138 | 235828 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 549 | 7 | 2 | 5 | 4.1 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)c1ccccn1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL338636 | 235828 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 549 | 7 | 2 | 5 | 4.1 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)c1ccccn1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL339493 | 487019 | 0 | None | None | None | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 664 | 4 | 2 | 6 | 1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](C)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 10386478 | 235854 | 0 | None | None | None | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 403 | 2 | 0 | 2 | 4.2 | O=S(=O)(c1ccc(Br)cc1)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| CHEMBL338757 | 235854 | 0 | None | None | None | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 403 | 2 | 0 | 2 | 4.2 | O=S(=O)(c1ccc(Br)cc1)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| 9983834 | 232062 | 0 | None | None | None | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 510 | 6 | 2 | 4 | 3.6 | CC1(C)[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@H](NC(=O)Cc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL337519 | 232062 | 0 | None | None | None | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 510 | 6 | 2 | 4 | 3.6 | CC1(C)[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@H](NC(=O)Cc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| 10026508 | 236756 | 0 | None | None | None | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 444 | 4 | 1 | 3 | 3.6 | CC(=O)N[C@@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL340320 | 236756 | 0 | None | None | None | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 444 | 4 | 1 | 3 | 3.6 | CC(=O)N[C@@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| 10031108 | 235468 | 0 | None | None | None | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 578 | 6 | 1 | 3 | 6.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C[C@]13C[C@H]4C[C@H](C[C@H](C4)C1)C3)C2 | 10.1021/jm00077a002 | |||
| CHEMBL336362 | 235468 | 0 | None | None | None | Rat | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 578 | 6 | 1 | 3 | 6.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C[C@]13C[C@H]4C[C@H](C[C@H](C4)C1)C3)C2 | 10.1021/jm00077a002 | |||
| 44273173 | 199254 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 555 | 7 | 0 | 5 | 4.0 | CCN(CC)[C@@H]1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| 44273417 | 199254 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 555 | 7 | 0 | 5 | 4.0 | CCN(CC)[C@@H]1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL280202 | 199254 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 555 | 7 | 0 | 5 | 4.0 | CCN(CC)[C@@H]1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL283317 | 199254 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 555 | 7 | 0 | 5 | 4.0 | CCN(CC)[C@@H]1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL338018 | 486995 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 807 | 10 | 4 | 7 | 3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 44273080 | 198876 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 571 | 7 | 1 | 7 | 2.4 | COC(=O)CNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL277022 | 198876 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 571 | 7 | 1 | 7 | 2.4 | COC(=O)CNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| 10031372 | 42735 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 592 | 7 | 2 | 6 | 2.1 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(CCS(N)(=O)=O)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL128258 | 42735 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 592 | 7 | 2 | 6 | 2.1 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(CCS(N)(=O)=O)C1=O)C2 | 10.1021/jm00077a002 | |||
| 10347928 | 237266 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 565 | 6 | 2 | 5 | 3.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(Cc3c[nH]cn3)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL341289 | 237266 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 565 | 6 | 2 | 5 | 3.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(Cc3c[nH]cn3)C1=O)C2 | 10.1021/jm00077a002 | |||
| 10326385 | 311623 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 609 | 7 | 2 | 8 | 2.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(CC(=O)Nc3nn[nH]n3)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL405016 | 311623 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 609 | 7 | 2 | 8 | 2.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(CC(=O)Nc3nn[nH]n3)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL406351 | 487907 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 1032 | 9 | 12 | 15 | -3.1 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@H](N)C(C)(C)SSC[C@@H]2NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(=O)NCCCC[C@H](C(=O)NCC(N)=O)NC(=O)[C@H]3CCCN3C2=O)NC1=O | 10.1021/jm0303103 | |||
| CHEMBL397407 | 487806 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 1068 | 17 | 12 | 15 | -2.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2Cc3ccccc3C[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | |||
| 10052640 | 44977 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 527 | 6 | 2 | 4 | 4.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CC1CCCNC1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL131239 | 44977 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 527 | 6 | 2 | 4 | 4.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CC1CCCNC1)C2 | 10.1021/jm00077a002 | |||
| 44352497 | 235921 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 472 | 5 | 2 | 4 | 3.1 | CC(=O)NC[C@@]1(O)C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL339151 | 235921 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 472 | 5 | 2 | 4 | 3.1 | CC(=O)NC[C@@]1(O)C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| 44350953 | 42165 | 0 | None | None | None | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 413 | 3 | 0 | 3 | 4.0 | CC1C(=O)[C@]2(CS(=O)(=O)N3CCC4(C=Cc5ccccc54)CC3)CCC1C2(C)C | 10.1021/jm00099a020 | |||
| CHEMBL127063 | 42165 | 0 | None | None | None | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 413 | 3 | 0 | 3 | 4.0 | CC1C(=O)[C@]2(CS(=O)(=O)N3CCC4(C=Cc5ccccc54)CC3)CCC1C2(C)C | 10.1021/jm00099a020 | |||
| 10455392 | 42708 | 0 | None | None | None | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 430 | 4 | 2 | 4 | 2.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CN)C2 | 10.1021/jm00077a002 | |||
| CHEMBL128124 | 42708 | 0 | None | None | None | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 430 | 4 | 2 | 4 | 2.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CN)C2 | 10.1021/jm00077a002 | |||
| CHEMBL234363 | 485347 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 1022 | 18 | 13 | 15 | -3.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | |||
| 10458629 | 42820 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 499 | 4 | 1 | 4 | 3.4 | CC1NC(=O)N([C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1021/jm00077a002 | |||
| CHEMBL128712 | 42820 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 499 | 4 | 1 | 4 | 3.4 | CC1NC(=O)N([C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1021/jm00077a002 | |||
| 10074681 | 235917 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 499 | 4 | 0 | 4 | 3.4 | CN1CC(=O)N([C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1021/jm00077a002 | |||
| CHEMBL339132 | 235917 | 0 | None | None | None | Rat | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 499 | 4 | 0 | 4 | 3.4 | CN1CC(=O)N([C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1021/jm00077a002 | |||
| 10435004 | 42747 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 473 | 6 | 2 | 4 | 3.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCN)C2 | 10.1021/jm00077a002 | |||
| CHEMBL128328 | 42747 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 473 | 6 | 2 | 4 | 3.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCN)C2 | 10.1021/jm00077a002 | |||
| 10075516 | 329159 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 524 | 7 | 1 | 5 | 3.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCn1ccnc1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL421090 | 329159 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 524 | 7 | 1 | 5 | 3.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCn1ccnc1)C2 | 10.1021/jm00077a002 | |||
| 10324129 | 333224 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 512 | 6 | 1 | 7 | 2.3 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cn1cnnn1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL435613 | 333224 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 512 | 6 | 1 | 7 | 2.3 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cn1cnnn1)C2 | 10.1021/jm00077a002 | |||
| 44351212 | 328368 | 0 | None | None | None | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 473 | 5 | 2 | 4 | 3.7 | CC(C(=O)O)[C@@]1(O)CC2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C | 10.1021/jm00099a020 | |||
| CHEMBL419422 | 328368 | 0 | None | None | None | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 473 | 5 | 2 | 4 | 3.7 | CC(C(=O)O)[C@@]1(O)CC2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C | 10.1021/jm00099a020 | |||
| CHEMBL1790937 | 484815 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 755 | 6 | 5 | 7 | 1.9 | CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| CHEMBL2370623 | 485596 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 739 | 6 | 2 | 7 | 2.7 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCC=NN2C1=O | 10.1021/jm00099a019 | |||
| CHEMBL338308 | 487001 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 742 | 9 | 4 | 8 | 1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCN)NC(=O)[C@H]2CCC=NN2C1=O | 10.1021/jm00099a019 | |||
| 14981577 | 160376 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 636 | 11 | 2 | 7 | 3.5 | Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)NC2CCCCC2)C3(C)C)CC1 | 10.1021/jm00031a004 | |||
| CHEMBL2112900 | 160376 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 636 | 11 | 2 | 7 | 3.5 | Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)NC2CCCCC2)C3(C)C)CC1 | 10.1021/jm00031a004 | |||
| 44273368 | 199036 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 584 | 9 | 1 | 6 | 3.2 | CN(C)CCCNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL278377 | 199036 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 584 | 9 | 1 | 6 | 3.2 | CN(C)CCCNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| 10347928 | 237266 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 565 | 6 | 2 | 5 | 3.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(Cc3c[nH]cn3)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL341289 | 237266 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 565 | 6 | 2 | 5 | 3.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(Cc3c[nH]cn3)C1=O)C2 | 10.1021/jm00077a002 | |||
| 121301508 | 350186 | 8 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 542 | 7 | 2 | 9 | 3.6 | C[C@H](O)c1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nn1-c1cccc(Cl)c1 | 10.6019/CHEMBL5463729 | |||
| CHEMBL4594444 | 350186 | 8 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 542 | 7 | 2 | 9 | 3.6 | C[C@H](O)c1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nn1-c1cccc(Cl)c1 | 10.6019/CHEMBL5463729 | |||
| DB16279 | 350186 | 8 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 542 | 7 | 2 | 9 | 3.6 | C[C@H](O)c1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nn1-c1cccc(Cl)c1 | 10.6019/CHEMBL5463729 | |||
| 44273173 | 199254 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 555 | 7 | 0 | 5 | 4.0 | CCN(CC)[C@@H]1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| 44273417 | 199254 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 555 | 7 | 0 | 5 | 4.0 | CCN(CC)[C@@H]1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL280202 | 199254 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 555 | 7 | 0 | 5 | 4.0 | CCN(CC)[C@@H]1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL283317 | 199254 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 555 | 7 | 0 | 5 | 4.0 | CCN(CC)[C@@H]1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| 10029340 | 42746 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 510 | 5 | 2 | 4 | 4.0 | Cc1[nH]cnc1C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL128327 | 42746 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 510 | 5 | 2 | 4 | 4.0 | Cc1[nH]cnc1C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| 10052468 | 44972 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 522 | 6 | 2 | 4 | 4.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)/C=C/c1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL131235 | 44972 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 522 | 6 | 2 | 4 | 4.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)/C=C/c1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| 10414877 | 45322 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 538 | 6 | 2 | 4 | 4.3 | CC(C)(C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C)c1c[nH]cn1 | 10.1021/jm00077a002 | |||
| CHEMBL131564 | 45322 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 538 | 6 | 2 | 4 | 4.3 | CC(C)(C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C)c1c[nH]cn1 | 10.1021/jm00077a002 | |||
| 44352353 | 235999 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 500 | 5 | 1 | 4 | 3.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@](O)(CN1CCCC1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL339357 | 235999 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 500 | 5 | 1 | 4 | 3.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@](O)(CN1CCCC1=O)C2 | 10.1021/jm00077a002 | |||
| 9982888 | 333139 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 486 | 6 | 2 | 4 | 3.5 | CC(=O)NCC[C@@]1(O)C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL435009 | 333139 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 486 | 6 | 2 | 4 | 3.5 | CC(=O)NCC[C@@]1(O)C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL339452 | 487017 | 0 | None | None | None | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 714 | 6 | 2 | 6 | 2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@@H](C)N(C)C1=O | 10.1021/jm00099a019 | |||
| CHEMBL436397 | 488628 | 0 | None | None | None | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 744 | 8 | 4 | 7 | 1.7 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 10054982 | 235818 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 645 | 10 | 2 | 6 | 3.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)N(CCc1c[nH]cn1)CCS(C)(=O)=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL338576 | 235818 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 645 | 10 | 2 | 6 | 3.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)N(CCc1c[nH]cn1)CCS(C)(=O)=O)C2 | 10.1021/jm00077a002 | |||
| 10347928 | 237266 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 565 | 6 | 2 | 5 | 3.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(Cc3c[nH]cn3)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL341289 | 237266 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 565 | 6 | 2 | 5 | 3.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(Cc3c[nH]cn3)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL2369135 | 485403 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 1089 | 10 | 11 | 15 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]([C@H](C)c2c(C)cc(OC)cc2C)NC(=O)[C@H](N)C(C)(C)SSC[C@@H]2NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(=O)NCCCC[C@H](C(=O)NCC(N)=O)NC(=O)[C@H]3CCCN3C2=O)NC1=O | 10.1021/jm0303103 | |||
| CHEMBL338294 | 486999 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 757 | 10 | 4 | 7 | 2.3 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 10006805 | 330168 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 517 | 6 | 2 | 5 | 3.0 | COC(=O)CNC(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL423156 | 330168 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 517 | 6 | 2 | 5 | 3.0 | COC(=O)CNC(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| 10361799 | 41898 | 0 | None | None | None | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 370 | 3 | 0 | 4 | 3.3 | O=[N+]([O-])c1ccc(S(=O)(=O)N2CCC3(C=Cc4ccccc43)CC2)cc1 | 10.1021/jm00099a020 | |||
| CHEMBL126453 | 41898 | 0 | None | None | None | Rat | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 370 | 3 | 0 | 4 | 3.3 | O=[N+]([O-])c1ccc(S(=O)(=O)N2CCC3(C=Cc4ccccc43)CC2)cc1 | 10.1021/jm00099a020 | |||
| 44272990 | 199743 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 500 | 4 | 1 | 5 | 2.6 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](O)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| 44273369 | 199743 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 500 | 4 | 1 | 5 | 2.6 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](O)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL283524 | 199743 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 500 | 4 | 1 | 5 | 2.6 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](O)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL283994 | 199743 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 500 | 4 | 1 | 5 | 2.6 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](O)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| 44352150 | 42724 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 515 | 7 | 2 | 5 | 2.8 | CC(C(N)=O)[C@@H](N)C(=O)[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL128194 | 42724 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 515 | 7 | 2 | 5 | 2.8 | CC(C(N)=O)[C@@H](N)C(=O)[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| 10098227 | 42814 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 521 | 6 | 1 | 4 | 4.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1cccnc1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL128680 | 42814 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 521 | 6 | 1 | 4 | 4.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1cccnc1)C2 | 10.1021/jm00077a002 | |||
| 10053091 | 44436 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 542 | 6 | 2 | 6 | 3.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1csc(N)n1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL130803 | 44436 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 542 | 6 | 2 | 6 | 3.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1csc(N)n1)C2 | 10.1021/jm00077a002 | |||
| 10098755 | 45332 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 538 | 7 | 2 | 4 | 4.5 | CCC(C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C)c1c[nH]cn1 | 10.1021/jm00077a002 | |||
| CHEMBL131581 | 45332 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 538 | 7 | 2 | 4 | 4.5 | CCC(C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C)c1c[nH]cn1 | 10.1021/jm00077a002 | |||
| 44352393 | 235748 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 555 | 6 | 3 | 4 | 4.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)NC1CCCCC1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL338177 | 235748 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 555 | 6 | 3 | 4 | 4.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)NC1CCCCC1)C2 | 10.1021/jm00077a002 | |||
| 44429288 | 178241 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 1081 | 19 | 10 | 14 | -0.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | |||
| 44429290 | 178241 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 1081 | 19 | 10 | 14 | -0.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | |||
| CHEMBL233328 | 178241 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 1081 | 19 | 10 | 14 | -0.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | |||
| CHEMBL234377 | 178241 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 1081 | 19 | 10 | 14 | -0.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | |||
| 2241 | 4522 | 5 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 738 | 6 | 2 | 8 | 2.3 | CC[C@@H]([C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](N(C(=O)[C@H]2N(C(=O)[C@@H]3N(C1=O)N=CCC3)N=CCC2)C)Cc1ccccc1)C | 10.1021/jm00099a019 | |||
| 9810632 | 4522 | 5 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 738 | 6 | 2 | 8 | 2.3 | CC[C@@H]([C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](N(C(=O)[C@H]2N(C(=O)[C@@H]3N(C1=O)N=CCC3)N=CCC2)C)Cc1ccccc1)C | 10.1021/jm00099a019 | |||
| CHEMBL127686 | 4522 | 5 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 738 | 6 | 2 | 8 | 2.3 | CC[C@@H]([C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](N(C(=O)[C@H]2N(C(=O)[C@@H]3N(C1=O)N=CCC3)N=CCC2)C)Cc1ccccc1)C | 10.1021/jm00099a019 | |||
| CHEMBL1790938 | 484816 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 769 | 6 | 4 | 7 | 2.3 | CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 14981576 | 160370 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 610 | 12 | 1 | 7 | 2.9 | CCN(CC)[C@@H](CCS(C)(=O)=O)C(=O)N[C@H]1CC2CC[C@]1(CS(=O)(=O)N1CCN(c3ccccc3C)CC1)C2(C)C | 10.1021/jm00031a004 | |||
| CHEMBL2112894 | 160370 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 610 | 12 | 1 | 7 | 2.9 | CCN(CC)[C@@H](CCS(C)(=O)=O)C(=O)N[C@H]1CC2CC[C@]1(CS(=O)(=O)N1CCN(c3ccccc3C)CC1)C2(C)C | 10.1021/jm00031a004 | |||
| 44273346 | 327964 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 570 | 8 | 1 | 6 | 2.8 | CN(C)CCNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL417458 | 327964 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 570 | 8 | 1 | 6 | 2.8 | CN(C)CCNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| 10051081 | 235777 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 485 | 4 | 1 | 4 | 3.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CNC1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL338383 | 235777 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 485 | 4 | 1 | 4 | 3.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CNC1=O)C2 | 10.1021/jm00077a002 | |||
| 44352441 | 44539 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 535 | 6 | 2 | 5 | 3.8 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)c1ccccn1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL130887 | 44539 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 535 | 6 | 2 | 5 | 3.8 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)c1ccccn1)C2 | 10.1021/jm00077a002 | |||
| 44352440 | 235661 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 535 | 6 | 2 | 5 | 3.8 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)c1ccncc1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL337667 | 235661 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 535 | 6 | 2 | 5 | 3.8 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)c1ccncc1)C2 | 10.1021/jm00077a002 | |||
| 10345259 | 235827 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 484 | 4 | 0 | 3 | 4.5 | CC1CCC(=O)N1[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL338635 | 235827 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 484 | 4 | 0 | 3 | 4.5 | CC1CCC(=O)N1[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| 10323684 | 235909 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 499 | 4 | 1 | 5 | 2.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(=O)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL339096 | 235909 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 499 | 4 | 1 | 5 | 2.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(=O)C1=O)C2 | 10.1021/jm00077a002 | |||
| 10347089 | 333133 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 535 | 7 | 1 | 4 | 4.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCc1cccnc1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL434993 | 333133 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 535 | 7 | 1 | 4 | 4.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCc1cccnc1)C2 | 10.1021/jm00077a002 | |||
| 44351086 | 42022 | 0 | None | None | None | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 399 | 3 | 0 | 3 | 3.8 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C(=O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL126962 | 42022 | 0 | None | None | None | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 399 | 3 | 0 | 3 | 3.8 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C(=O)C2 | 10.1021/jm00099a020 | |||
| 10069537 | 327527 | 0 | None | None | None | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 399 | 3 | 0 | 3 | 3.8 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C(=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL420144 | 327527 | 0 | None | None | None | Rat | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 399 | 3 | 0 | 3 | 3.8 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C(=O)C2 | 10.1021/jm00077a002 | |||
| 10054203 | 236875 | 0 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 593 | 8 | 0 | 6 | 4.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CN(CCCn3ccnc3)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL340388 | 236875 | 0 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 593 | 8 | 0 | 6 | 4.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CN(CCCn3ccnc3)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL338020 | 486996 | 0 | None | None | None | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 755 | 6 | 5 | 7 | 1.9 | CC(C)C[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| CHEMBL340479 | 487026 | 0 | None | None | None | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 766 | 8 | 2 | 6 | 3.6 | C=CCN1C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H]1Cc1ccccc1 | 10.1021/jm00099a019 | |||
| 10436274 | 198767 | 0 | None | None | None | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 507 | 5 | 1 | 4 | 4.3 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)c1ccncc1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL276079 | 198767 | 0 | None | None | None | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 507 | 5 | 1 | 4 | 4.3 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)c1ccncc1)C2 | 10.1021/jm00077a002 | |||
| 44351071 | 43881 | 0 | None | None | None | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 419 | 3 | 1 | 3 | 3.7 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4cc(F)ccc43)CC1)[C@@H](O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL130351 | 43881 | 0 | None | None | None | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 419 | 3 | 1 | 3 | 3.7 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4cc(F)ccc43)CC1)[C@@H](O)C2 | 10.1021/jm00099a020 | |||
| 44351053 | 237264 | 0 | None | None | None | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 419 | 3 | 1 | 3 | 3.7 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccc(F)cc43)CC1)[C@@H](O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL341274 | 237264 | 0 | None | None | None | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 419 | 3 | 1 | 3 | 3.7 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccc(F)cc43)CC1)[C@@H](O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL2370761 | 485613 | 0 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 1089 | 10 | 11 | 15 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H]([C@H](C)c2c(C)cc(OC)cc2C)NC(=O)[C@H](N)C(C)(C)SSC[C@@H]2NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(=O)NCCCC[C@H](C(=O)NCC(N)=O)NC(=O)[C@H]3CCCN3C2=O)NC1=O | 10.1021/jm0303103 | |||
| CHEMBL2112249 | 485097 | 2 | None | None | None | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 766 | 6 | 4 | 7 | 2.6 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 11764710 | 235356 | 0 | None | None | None | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 638 | 11 | 4 | 6 | 2.3 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)Cc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL336082 | 235356 | 0 | None | None | None | Rat | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 638 | 11 | 4 | 6 | 2.3 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)Cc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| 10078034 | 236315 | 0 | None | None | None | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 652 | 11 | 3 | 7 | 2.3 | Cn1cncc1CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL339929 | 236315 | 0 | None | None | None | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 652 | 11 | 3 | 7 | 2.3 | Cn1cncc1CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| 14981578 | 160373 | 0 | None | None | None | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 638 | 11 | 2 | 8 | 2.3 | Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)NC2CCOCC2)C3(C)C)CC1 | 10.1021/jm00031a004 | |||
| CHEMBL2112897 | 160373 | 0 | None | None | None | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 638 | 11 | 2 | 8 | 2.3 | Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)NC2CCOCC2)C3(C)C)CC1 | 10.1021/jm00031a004 | |||
| 10483586 | 44546 | 0 | None | None | None | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 591 | 7 | 1 | 6 | 2.8 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(CCS(C)(=O)=O)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL130891 | 44546 | 0 | None | None | None | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 591 | 7 | 1 | 6 | 2.8 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(CCS(C)(=O)=O)C1=O)C2 | 10.1021/jm00077a002 | |||
| 2042 | 8014 | 41 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.ejmech.2006.12.016 | |||
| 2176 | 8014 | 41 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.ejmech.2006.12.016 | |||
| 439302 | 8014 | 41 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.ejmech.2006.12.016 | |||
| CHEMBL395429 | 8014 | 41 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.ejmech.2006.12.016 | |||
| 71450903 | 160377 | 0 | None | None | None | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 614 | 12 | 3 | 9 | 0.8 | Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)N(CO)CO)C3(C)C)CC1 | 10.1021/jm00031a004 | |||
| CHEMBL2112901 | 160377 | 0 | None | None | None | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 614 | 12 | 3 | 9 | 0.8 | Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)N(CO)CO)C3(C)C)CC1 | 10.1021/jm00031a004 | |||
| CHEMBL2112651 | 485103 | 0 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 779 | 6 | 3 | 6 | 3.6 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 44273259 | 155213 | 0 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 557 | 7 | 1 | 6 | 2.5 | CN(CCO)C1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL20171 | 155213 | 0 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 557 | 7 | 1 | 6 | 2.5 | CN(CCO)C1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| 44273355 | 156615 | 0 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 587 | 8 | 0 | 6 | 3.9 | CN(C)CCSC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL20319 | 156615 | 0 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 587 | 8 | 0 | 6 | 3.9 | CN(C)CCSC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| 44273426 | 158748 | 0 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 557 | 7 | 2 | 6 | 2.6 | C[C@H](CO)NC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL20757 | 158748 | 0 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 557 | 7 | 2 | 6 | 2.6 | C[C@H](CO)NC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| 44272990 | 199743 | 0 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 500 | 4 | 1 | 5 | 2.6 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](O)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| 44273369 | 199743 | 0 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 500 | 4 | 1 | 5 | 2.6 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](O)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL283524 | 199743 | 0 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 500 | 4 | 1 | 5 | 2.6 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](O)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL283994 | 199743 | 0 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 500 | 4 | 1 | 5 | 2.6 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](O)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| 44352164 | 42753 | 0 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 541 | 4 | 1 | 5 | 2.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C3CC(O)CN3C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL128383 | 42753 | 0 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 541 | 4 | 1 | 5 | 2.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C3CC(O)CN3C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL339118 | 487010 | 0 | None | None | None | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 740 | 6 | 2 | 6 | 3.1 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 44273077 | 199110 | 0 | None | None | None | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 589 | 7 | 1 | 5 | 4.4 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](NCc3ccccc3)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| 44273316 | 199110 | 0 | None | None | None | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 589 | 7 | 1 | 5 | 4.4 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](NCc3ccccc3)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL279022 | 199110 | 0 | None | None | None | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 589 | 7 | 1 | 5 | 4.4 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](NCc3ccccc3)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL281361 | 199110 | 0 | None | None | None | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 589 | 7 | 1 | 5 | 4.4 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](NCc3ccccc3)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| 44352165 | 237351 | 0 | None | None | None | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 552 | 7 | 3 | 6 | 1.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(N)CS(N)(=O)=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL341507 | 237351 | 0 | None | None | None | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 552 | 7 | 3 | 6 | 1.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(N)CS(N)(=O)=O)C2 | 10.1021/jm00077a002 | |||
| 44350916 | 232105 | 0 | None | None | None | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 417 | 3 | 1 | 3 | 3.9 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCCc4ccccc43)CC1)[C@H](O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL340102 | 232105 | 0 | None | None | None | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 417 | 3 | 1 | 3 | 3.9 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCCc4ccccc43)CC1)[C@H](O)C2 | 10.1021/jm00099a020 | |||
| 44352496 | 43411 | 0 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 538 | 4 | 1 | 5 | 3.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C3CCC(=N)N3C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL129983 | 43411 | 0 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 538 | 4 | 1 | 5 | 3.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C3CCC(=N)N3C1=O)C2 | 10.1021/jm00077a002 | |||
| 10391259 | 42755 | 0 | None | None | None | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 499 | 5 | 1 | 4 | 3.3 | CNC1CCN([C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1021/jm00077a002 | |||
| CHEMBL128388 | 42755 | 0 | None | None | None | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 499 | 5 | 1 | 4 | 3.3 | CNC1CCN([C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1021/jm00077a002 | |||
| 44342196 | 220380 | 0 | None | None | None | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 428 | 6 | 0 | 7 | 5.1 | COc1cc(C)cc2c1Oc1ccc([C@H](CC(C)C)OC(C)=O)c(OC)c1C(=O)OC2 | 10.1016/S0960-894X(01)80905-7 | |||
| CHEMBL326085 | 220380 | 0 | None | None | None | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 428 | 6 | 0 | 7 | 5.1 | COc1cc(C)cc2c1Oc1ccc([C@H](CC(C)C)OC(C)=O)c(OC)c1C(=O)OC2 | 10.1016/S0960-894X(01)80905-7 | |||
| CHEMBL339450 | 487016 | 0 | None | None | None | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 766 | 8 | 4 | 7 | 2.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 10007685 | 198858 | 0 | None | None | None | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 548 | 7 | 2 | 4 | 4.8 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)c1ccccc1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL276906 | 198858 | 0 | None | None | None | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 548 | 7 | 2 | 4 | 4.8 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)c1ccccc1)C2 | 10.1021/jm00077a002 | |||
| 10052134 | 236769 | 0 | None | None | None | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 512 | 6 | 2 | 6 | 2.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1nnn[nH]1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL340334 | 236769 | 0 | None | None | None | Rat | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 512 | 6 | 2 | 6 | 2.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1nnn[nH]1)C2 | 10.1021/jm00077a002 | |||
| 44350954 | 42233 | 0 | None | None | None | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 401 | 3 | 1 | 3 | 3.6 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@H](O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL127118 | 42233 | 0 | None | None | None | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 401 | 3 | 1 | 3 | 3.6 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@H](O)C2 | 10.1021/jm00099a020 | |||
| 44350850 | 235908 | 0 | None | None | None | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 3.4 | CC1(C)C2CC[C@@]1(CS(=O)(=O)NCCC1CCc3ccccc31)C(=O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL339093 | 235908 | 0 | None | None | None | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 3.4 | CC1(C)C2CC[C@@]1(CS(=O)(=O)NCCC1CCc3ccccc31)C(=O)C2 | 10.1021/jm00099a020 | |||
| 10386343 | 42776 | 0 | None | None | None | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 401 | 3 | 1 | 3 | 3.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@H](O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL128497 | 42776 | 0 | None | None | None | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 401 | 3 | 1 | 3 | 3.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@H](O)C2 | 10.1021/jm00077a002 | |||
| 10315031 | 237145 | 0 | None | None | None | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 337 | 2 | 0 | 1 | 5.3 | O=C(CC1CCCCCCC1)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| CHEMBL341021 | 237145 | 0 | None | None | None | Rat | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 337 | 2 | 0 | 1 | 5.3 | O=C(CC1CCCCCCC1)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| 10393977 | 333197 | 0 | None | None | None | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 611 | 10 | 3 | 5 | 3.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)N(CCC(=O)O)CCc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL435409 | 333197 | 0 | None | None | None | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 611 | 10 | 3 | 5 | 3.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)N(CCC(=O)O)CCc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| 44351231 | 43288 | 0 | None | None | None | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 417 | 3 | 0 | 3 | 3.9 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccc(F)cc43)CC1)C(=O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL129498 | 43288 | 0 | None | None | None | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 417 | 3 | 0 | 3 | 3.9 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccc(F)cc43)CC1)C(=O)C2 | 10.1021/jm00099a020 | |||
| 44351156 | 235747 | 0 | None | None | None | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 417 | 3 | 0 | 3 | 3.9 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4cc(F)ccc43)CC1)C(=O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL338170 | 235747 | 0 | None | None | None | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 417 | 3 | 0 | 3 | 3.9 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4cc(F)ccc43)CC1)C(=O)C2 | 10.1021/jm00099a020 | |||
| 44273459 | 155610 | 0 | None | None | None | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 482 | 4 | 0 | 4 | 3.4 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C=CC1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL20205 | 155610 | 0 | None | None | None | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 482 | 4 | 0 | 4 | 3.4 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C=CC1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| 10459672 | 236333 | 0 | None | None | None | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 530 | 8 | 1 | 5 | 4.0 | CCOC(=O)CCC(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL340016 | 236333 | 0 | None | None | None | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 530 | 8 | 1 | 5 | 4.0 | CCOC(=O)CCC(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| 44351226 | 232116 | 0 | None | None | None | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 399 | 3 | 0 | 3 | 3.8 | CC1(C)C2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C(=O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL341267 | 232116 | 0 | None | None | None | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 399 | 3 | 0 | 3 | 3.8 | CC1(C)C2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C(=O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL126765 | 484594 | 0 | None | None | None | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 781 | 9 | 5 | 8 | 2.0 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCN)NC(=O)[C@H]2CCC=NN2C1=O | 10.1021/jm00099a019 | |||
| 44429294 | 333024 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 1184 | 18 | 9 | 14 | 0.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)N3Cc4ccccc4C[C@@H]3C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | |||
| CHEMBL434193 | 333024 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 1184 | 18 | 9 | 14 | 0.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)N3Cc4ccccc4C[C@@H]3C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | |||
| 44273473 | 144997 | 0 | None | None | None | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 542 | 5 | 0 | 6 | 3.2 | CC(=O)OC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL20002 | 144997 | 0 | None | None | None | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 542 | 5 | 0 | 6 | 3.2 | CC(=O)OC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| 10369423 | 327749 | 0 | None | None | None | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 520 | 6 | 1 | 3 | 4.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1ccccc1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL435815 | 327749 | 0 | None | None | None | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 520 | 6 | 1 | 3 | 4.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1ccccc1)C2 | 10.1021/jm00077a002 | |||
| 44351087 | 232076 | 0 | None | None | None | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 401 | 3 | 1 | 3 | 3.6 | CC1(C)C2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@H](O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL338336 | 232076 | 0 | None | None | None | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 401 | 3 | 1 | 3 | 3.6 | CC1(C)C2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@H](O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL338221 | 486998 | 0 | None | None | None | Rat | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 754 | 6 | 1 | 6 | 3.4 | CC[C@H](C)[C@H]1C(=O)N2CCCC[C@@H]2C(=O)N2CCCC[C@H]2C(=O)N(C)[C@H](Cc2ccccc2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)N1C | 10.1021/jm00099a019 | |||
| 10391520 | 44394 | 0 | None | None | None | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 507 | 5 | 1 | 4 | 4.3 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)c1cccnc1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL130770 | 44394 | 0 | None | None | None | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 507 | 5 | 1 | 4 | 4.3 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)c1cccnc1)C2 | 10.1021/jm00077a002 | |||
| 44352363 | 235192 | 0 | None | None | None | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 626 | 6 | 2 | 6 | 3.7 | COC(=O)[N+]12CCC(CC1)C(C(=O)NC[C@@]1(O)C[C@H]3CC[C@]1(CS(=O)(=O)N1CCC4(C=Cc5ccccc54)CC1)C3(C)C)C2 | 10.1021/jm00077a002 | |||
| CHEMBL335886 | 235192 | 0 | None | None | None | Rat | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 626 | 6 | 2 | 6 | 3.7 | COC(=O)[N+]12CCC(CC1)C(C(=O)NC[C@@]1(O)C[C@H]3CC[C@]1(CS(=O)(=O)N1CCC4(C=Cc5ccccc54)CC1)C3(C)C)C2 | 10.1021/jm00077a002 | |||
| 11756226 | 45791 | 0 | None | None | None | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 514 | 5 | 1 | 4 | 3.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CCC1C(=O)O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL132064 | 45791 | 0 | None | None | None | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 514 | 5 | 1 | 4 | 3.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CCC1C(=O)O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL129414 | 484607 | 0 | None | None | None | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 714 | 6 | 2 | 6 | 2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](C)N(C)C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 10459923 | 235261 | 0 | None | None | None | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 539 | 5 | 1 | 4 | 3.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C1CN3CCC1CC3)C2 | 10.1021/jm00077a002 | |||
| CHEMBL335944 | 235261 | 0 | None | None | None | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 539 | 5 | 1 | 4 | 3.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C1CN3CCC1CC3)C2 | 10.1021/jm00077a002 | |||
| 10415322 | 332953 | 0 | None | None | None | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 556 | 7 | 2 | 5 | 2.7 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(CCC(N)=O)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL433662 | 332953 | 0 | None | None | None | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 556 | 7 | 2 | 5 | 2.7 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(CCC(N)=O)C1=O)C2 | 10.1021/jm00077a002 | |||
| 10393965 | 45889 | 0 | None | None | None | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 610 | 7 | 3 | 8 | 2.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(CC(=O)Nc3nn[nH]n3)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL132157 | 45889 | 0 | None | None | None | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 610 | 7 | 3 | 8 | 2.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(CC(=O)Nc3nn[nH]n3)C1=O)C2 | 10.1021/jm00077a002 | |||
| 10392579 | 235593 | 0 | None | None | None | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 542 | 6 | 1 | 5 | 3.3 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(CC(=O)O)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL337221 | 235593 | 0 | None | None | None | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 542 | 6 | 1 | 5 | 3.3 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(CC(=O)O)C1=O)C2 | 10.1021/jm00077a002 | |||
| 44352481 | 235886 | 0 | None | None | None | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 621 | 11 | 1 | 6 | 3.8 | CCN(CC)C(CCS(C)(=O)=O)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL338951 | 235886 | 0 | None | None | None | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 621 | 11 | 1 | 6 | 3.8 | CCN(CC)C(CCS(C)(=O)=O)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| 9984805 | 235922 | 0 | None | None | None | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 541 | 7 | 2 | 4 | 4.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCC1CCCNC1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL339155 | 235922 | 0 | None | None | None | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 541 | 7 | 2 | 4 | 4.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCC1CCCNC1)C2 | 10.1021/jm00077a002 | |||
| 10053396 | 234103 | 0 | None | None | None | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 554 | 8 | 3 | 7 | 2.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)Cc1nnn[nH]1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL334332 | 234103 | 0 | None | None | None | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 554 | 8 | 3 | 7 | 2.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)Cc1nnn[nH]1)C2 | 10.1021/jm00077a002 | |||
| 137485426 | 405655 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 496 | 3 | 0 | 7 | 4.9 | CCOC(=O)N1Cc2cc(Cl)ccc2-n2c(C3CC4(C3)CN(c3ccc(F)cn3)C4)nnc2C1C | nan | |||
| CHEMBL5747690 | 405655 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 496 | 3 | 0 | 7 | 4.9 | CCOC(=O)N1Cc2cc(Cl)ccc2-n2c(C3CC4(C3)CN(c3ccc(F)cn3)C4)nnc2C1C | nan | |||
| 137485564 | 405962 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 542 | 4 | 0 | 7 | 5.6 | CC1c2nnc(C3CC4(C3)CN(c3ccc(F)cn3)C4)n2-c2ccc(Cl)cc2CN1C(=O)OC(C)(C)CF | nan | |||
| CHEMBL5750443 | 405962 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 542 | 4 | 0 | 7 | 5.6 | CC1c2nnc(C3CC4(C3)CN(c3ccc(F)cn3)C4)n2-c2ccc(Cl)cc2CN1C(=O)OC(C)(C)CF | nan | |||
| 137357530 | 406425 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 508 | 3 | 0 | 7 | 5.0 | CC1c2nnc(C3CC4(C3)CN(c3ccc(F)cn3)C4)n2-c2ccc(Cl)cc2CN1C(=O)OC1CC1 | nan | |||
| CHEMBL5754963 | 406425 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 508 | 3 | 0 | 7 | 5.0 | CC1c2nnc(C3CC4(C3)CN(c3ccc(F)cn3)C4)n2-c2ccc(Cl)cc2CN1C(=O)OC1CC1 | nan | |||
| 137485144 | 409231 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 489 | 2 | 0 | 6 | 4.6 | O=C(N1Cc2cc(Cl)ccc2-c2c(C3CC4(C3)CN(c3cccnn3)C4)noc2C1)C(F)(F)F | nan | |||
| CHEMBL5783623 | 409231 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 489 | 2 | 0 | 6 | 4.6 | O=C(N1Cc2cc(Cl)ccc2-c2c(C3CC4(C3)CN(c3cccnn3)C4)noc2C1)C(F)(F)F | nan | |||
| 137484998 | 410615 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 532 | 5 | 0 | 7 | 4.6 | O=C(OC(CF)CF)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2ccc(F)cn2)C3)C1 | nan | |||
| CHEMBL5798429 | 410615 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 532 | 5 | 0 | 7 | 4.6 | O=C(OC(CF)CF)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2ccc(F)cn2)C3)C1 | nan | |||
| 137485029 | 413448 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 482 | 3 | 0 | 7 | 4.3 | CCOC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2ccc(F)cn2)C3)C1 | nan | |||
| CHEMBL5829896 | 413448 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 482 | 3 | 0 | 7 | 4.3 | CCOC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2ccc(F)cn2)C3)C1 | nan | |||
| 137485455 | 413454 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 492 | 3 | 0 | 6 | 4.6 | CC1c2nnc(C3CC4(C3)CN(c3ccccn3)C4)n2-c2ccc(Cl)cc2CN1C(=O)C1(F)CC1 | nan | |||
| CHEMBL5829963 | 413454 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 492 | 3 | 0 | 6 | 4.6 | CC1c2nnc(C3CC4(C3)CN(c3ccccn3)C4)n2-c2ccc(Cl)cc2CN1C(=O)C1(F)CC1 | nan | |||
| 137485333 | 427110 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 512 | 3 | 0 | 6 | 5.0 | CC1c2nnc(C3CC4(C3)CN(c3ccc(F)cn3)C4)n2-c2ccc(Cl)cc2CN1C(=O)C(C)(C)F | nan | |||
| CHEMBL5872268 | 427110 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 512 | 3 | 0 | 6 | 5.0 | CC1c2nnc(C3CC4(C3)CN(c3ccc(F)cn3)C4)n2-c2ccc(Cl)cc2CN1C(=O)C(C)(C)F | nan | |||
| 137485199 | 427154 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 493 | 3 | 0 | 8 | 4.5 | CC(C)OC(=O)N1Cc2cc(Cl)ccc2-n2c(C3CC4(C3)CN(c3cnccn3)C4)nnc2C1C | nan | |||
| CHEMBL5872742 | 427154 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 493 | 3 | 0 | 8 | 4.5 | CC(C)OC(=O)N1Cc2cc(Cl)ccc2-n2c(C3CC4(C3)CN(c3cnccn3)C4)nnc2C1C | nan | |||
| 137485194 | 427433 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 510 | 3 | 0 | 7 | 5.3 | CC(C)OC(=O)N1Cc2cc(Cl)ccc2-n2c(C3CC4(C3)CN(c3ccc(F)cn3)C4)nnc2C1C | nan | |||
| CHEMBL5875761 | 427433 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 510 | 3 | 0 | 7 | 5.3 | CC(C)OC(=O)N1Cc2cc(Cl)ccc2-n2c(C3CC4(C3)CN(c3ccc(F)cn3)C4)nnc2C1C | nan | |||
| 137484973 | 431151 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 494 | 3 | 0 | 7 | 4.5 | O=C(OC1CC1)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2ccc(F)cn2)C3)C1 | nan | |||
| CHEMBL5914733 | 431151 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 494 | 3 | 0 | 7 | 4.5 | O=C(OC1CC1)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2ccc(F)cn2)C3)C1 | nan | |||
| 137485004 | 431494 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 478 | 3 | 0 | 7 | 4.6 | CC(C)OC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2cccnc2)C3)C1 | nan | |||
| CHEMBL5918284 | 431494 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 478 | 3 | 0 | 7 | 4.6 | CC(C)OC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2cccnc2)C3)C1 | nan | |||
| 137485329 | 432207 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 478 | 2 | 0 | 7 | 4.7 | COC(=O)N1Cc2cc(Cl)ccc2-n2c(C3CC4(C3)CN(c3cccc(C)n3)C4)nnc2C1C | nan | |||
| CHEMBL5925462 | 432207 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 478 | 2 | 0 | 7 | 4.7 | COC(=O)N1Cc2cc(Cl)ccc2-n2c(C3CC4(C3)CN(c3cccc(C)n3)C4)nnc2C1C | nan | |||
| 137485282 | 445178 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 546 | 5 | 0 | 7 | 5.2 | CC1c2nnc(C3CC4(C3)CN(c3ccc(F)cn3)C4)n2-c2ccc(Cl)cc2CN1C(=O)OC(CF)CF | nan | |||
| CHEMBL5958710 | 445178 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 546 | 5 | 0 | 7 | 5.2 | CC1c2nnc(C3CC4(C3)CN(c3ccc(F)cn3)C4)n2-c2ccc(Cl)cc2CN1C(=O)OC(CF)CF | nan | |||
| 137484991 | 445375 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 496 | 3 | 0 | 7 | 4.7 | CC(C)OC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2ccc(F)cn2)C3)C1 | nan | |||
| CHEMBL5960656 | 445375 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 496 | 3 | 0 | 7 | 4.7 | CC(C)OC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2ccc(F)cn2)C3)C1 | nan | |||
| 137485107 | 447239 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 517 | 3 | 0 | 8 | 5.0 | CC(C)OC(=O)N1Cc2cc(Cl)ccc2-n2c(C3CC4(C3)CN(c3cccc(C#N)n3)C4)nnc2C1C | nan | |||
| CHEMBL5981302 | 447239 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 517 | 3 | 0 | 8 | 5.0 | CC(C)OC(=O)N1Cc2cc(Cl)ccc2-n2c(C3CC4(C3)CN(c3cccc(C#N)n3)C4)nnc2C1C | nan | |||
| 137485118 | 447598 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 514 | 4 | 0 | 7 | 4.6 | CC(CF)OC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2ccc(F)cn2)C3)C1 | nan | |||
| CHEMBL5985111 | 447598 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 514 | 4 | 0 | 7 | 4.6 | CC(CF)OC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2ccc(F)cn2)C3)C1 | nan | |||
| 137485305 | 448665 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 523 | 3 | 0 | 8 | 4.8 | CC1c2nnc(C3CC4(C3)CN(c3ncc(F)cn3)C4)n2-c2ccc(Cl)cc2CN1C(=O)OC1(C)CC1 | nan | |||
| CHEMBL5996010 | 448665 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 523 | 3 | 0 | 8 | 4.8 | CC1c2nnc(C3CC4(C3)CN(c3ncc(F)cn3)C4)n2-c2ccc(Cl)cc2CN1C(=O)OC1(C)CC1 | nan | |||
| 137485053 | 449039 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 510 | 3 | 0 | 6 | 4.7 | CC1c2nnc(C3CC4(C3)CN(c3ccc(F)cn3)C4)n2-c2ccc(Cl)cc2CN1C(=O)C1(F)CC1 | nan | |||
| CHEMBL6000224 | 449039 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 510 | 3 | 0 | 6 | 4.7 | CC1c2nnc(C3CC4(C3)CN(c3ccc(F)cn3)C4)n2-c2ccc(Cl)cc2CN1C(=O)C1(F)CC1 | nan | |||
| 137485083 | 463429 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 483 | 2 | 0 | 8 | 3.9 | COC(=O)N1Cc2cc(Cl)ccc2-n2c(C3CC4(C3)CN(c3ncncc3F)C4)nnc2C1C | nan | |||
| CHEMBL6049639 | 463429 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 483 | 2 | 0 | 8 | 3.9 | COC(=O)N1Cc2cc(Cl)ccc2-n2c(C3CC4(C3)CN(c3ncncc3F)C4)nnc2C1C | nan | |||
| 10407141 | 40882 | 0 | None | None | None | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 375 | 2 | 0 | 2 | 4.6 | O=S(=O)(c1ccc2ccccc2c1)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| CHEMBL125406 | 40882 | 0 | None | None | None | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 375 | 2 | 0 | 2 | 4.6 | O=S(=O)(c1ccc2ccccc2c1)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| 44351225 | 41884 | 0 | None | None | None | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.5 | CC1(C)C2CC[C@](CS(=O)(=O)N3CCC4(CCc5ccccc54)CC3)(C2)C1O | 10.1021/jm00099a020 | |||
| CHEMBL126371 | 41884 | 0 | None | None | None | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.5 | CC1(C)C2CC[C@](CS(=O)(=O)N3CCC4(CCc5ccccc54)CC3)(C2)C1O | 10.1021/jm00099a020 | |||
| 10068542 | 41919 | 0 | None | None | None | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 383 | 3 | 0 | 4 | 3.2 | COC(=O)c1ccccc1S(=O)(=O)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| CHEMBL126565 | 41919 | 0 | None | None | None | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 383 | 3 | 0 | 4 | 3.2 | COC(=O)c1ccccc1S(=O)(=O)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| 44351265 | 236910 | 0 | None | None | None | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 486 | 5 | 1 | 4 | 3.4 | CC(C)C(=O)NC1C(=O)[C@]2(CS(=O)(=O)N3CCC4(CCc5ccccc54)CC3)CCC1C2(C)C | 10.1021/jm00099a020 | |||
| CHEMBL340589 | 236910 | 0 | None | None | None | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 486 | 5 | 1 | 4 | 3.4 | CC(C)C(=O)NC1C(=O)[C@]2(CS(=O)(=O)N3CCC4(CCc5ccccc54)CC3)CCC1C2(C)C | 10.1021/jm00099a020 | |||
| CHEMBL2112656 | 485106 | 0 | None | None | None | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 698 | 4 | 2 | 6 | 2.1 | C[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 10250542 | 232031 | 0 | None | None | None | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 402 | 3 | 1 | 3 | 3.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N)C2 | 10.1021/jm00077a002 | |||
| CHEMBL335170 | 232031 | 0 | None | None | None | Rat | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 402 | 3 | 1 | 3 | 3.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N)C2 | 10.1021/jm00077a002 | |||
| 10416272 | 214451 | 4 | None | None | None | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 608 | 6 | 1 | 7 | 4.7 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL31065 | 214451 | 4 | None | None | None | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 608 | 6 | 1 | 7 | 4.7 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| 9983763 | 43239 | 0 | None | None | None | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 508 | 7 | 1 | 4 | 3.8 | CCCS(=O)(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL129234 | 43239 | 0 | None | None | None | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 508 | 7 | 1 | 4 | 3.8 | CCCS(=O)(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| 44272960 | 145473 | 0 | None | None | None | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 527 | 6 | 1 | 5 | 3.2 | CCNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL20126 | 145473 | 0 | None | None | None | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 527 | 6 | 1 | 5 | 3.2 | CCNC1CC(=O)N([C@H]2CC3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1016/0960-894X(94)00469-V | |||
| 44352311 | 42809 | 0 | None | None | None | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 638 | 11 | 4 | 6 | 2.3 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@@H](Cc1c[nH]cn1)NC(=O)CCC(N)=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL128652 | 42809 | 0 | None | None | None | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 638 | 11 | 4 | 6 | 2.3 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@@H](Cc1c[nH]cn1)NC(=O)CCC(N)=O)C2 | 10.1021/jm00077a002 | |||
| 10100280 | 197144 | 0 | None | None | None | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 610 | 9 | 0 | 7 | 3.9 | COC(=O)CCN(C(=O)Cc1cn(C)cn1)[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL265073 | 197144 | 0 | None | None | None | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 610 | 9 | 0 | 7 | 3.9 | COC(=O)CCN(C(=O)Cc1cn(C)cn1)[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| 10392298 | 235699 | 0 | None | None | None | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 532 | 8 | 2 | 6 | 2.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(N)CC[N+](=O)[O-])C2 | 10.1021/jm00077a002 | |||
| CHEMBL337888 | 235699 | 0 | None | None | None | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 532 | 8 | 2 | 6 | 2.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(N)CC[N+](=O)[O-])C2 | 10.1021/jm00077a002 | |||
| CHEMBL129733 | 484608 | 0 | None | None | None | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 726 | 6 | 3 | 6 | 2.7 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 44350982 | 42065 | 0 | None | None | None | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.5 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@H](O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL126999 | 42065 | 0 | None | None | None | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 403 | 3 | 1 | 3 | 3.5 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@H](O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL52813 | 489209 | 0 | None | None | None | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 712 | 6 | 2 | 6 | 2.3 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O | 10.1021/jm00099a019 | |||
| 44268726 | 197677 | 0 | None | None | None | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 427 | 3 | 0 | 3 | 4.4 | CC1(C)C(=O)[C@]2(CS(=O)(=O)N3CCC4(C=Cc5ccccc54)CC3)CCC1C2(C)C | 10.1021/jm00099a020 | |||
| CHEMBL269624 | 197677 | 0 | None | None | None | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 427 | 3 | 0 | 3 | 4.4 | CC1(C)C(=O)[C@]2(CS(=O)(=O)N3CCC4(C=Cc5ccccc54)CC3)CCC1C2(C)C | 10.1021/jm00099a020 | |||
| 44351266 | 237056 | 0 | None | None | None | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 458 | 4 | 1 | 4 | 2.8 | CC(=O)NC1C(=O)[C@]2(CS(=O)(=O)N3CCC4(CCc5ccccc54)CC3)CCC1C2(C)C | 10.1021/jm00099a020 | |||
| CHEMBL340920 | 237056 | 0 | None | None | None | Rat | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 458 | 4 | 1 | 4 | 2.8 | CC(=O)NC1C(=O)[C@]2(CS(=O)(=O)N3CCC4(CCc5ccccc54)CC3)CCC1C2(C)C | 10.1021/jm00099a020 | |||
| 10029477 | 44560 | 0 | None | None | None | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 514 | 5 | 2 | 5 | 2.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(CN)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL130905 | 44560 | 0 | None | None | None | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 514 | 5 | 2 | 5 | 2.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(CN)C1=O)C2 | 10.1021/jm00077a002 | |||
| 44352412 | 234438 | 0 | None | None | None | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 549 | 7 | 2 | 5 | 3.7 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)Cc1ccncc1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL335182 | 234438 | 0 | None | None | None | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 549 | 7 | 2 | 5 | 3.7 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)Cc1ccncc1)C2 | 10.1021/jm00077a002 | |||
| 44351232 | 44295 | 0 | None | None | None | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 473 | 5 | 1 | 5 | 3.5 | COC(=O)C[C@@]1(O)CC2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C | 10.1021/jm00099a020 | |||
| CHEMBL130695 | 44295 | 0 | None | None | None | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 473 | 5 | 1 | 5 | 3.5 | COC(=O)C[C@@]1(O)CC2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C | 10.1021/jm00099a020 | |||
| 3537 | 8682 | 25 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 402 | 2 | 0 | 4 | 4.8 | Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 | 10.1016/j.bmcl.2007.08.053 | |||
| 5311500 | 8682 | 25 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 402 | 2 | 0 | 4 | 4.8 | Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 | 10.1016/j.bmcl.2007.08.053 | |||
| CHEMBL363910 | 8682 | 25 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 402 | 2 | 0 | 4 | 4.8 | Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 | 10.1016/j.bmcl.2007.08.053 | |||
| 10393379 | 44028 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 576 | 6 | 1 | 5 | 4.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(Cc3cccnc3)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL130476 | 44028 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 576 | 6 | 1 | 5 | 4.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(Cc3cccnc3)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL2370768 | 485614 | 0 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 1089 | 10 | 11 | 15 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]([C@@H](C)c2c(C)cc(OC)cc2C)NC(=O)[C@H](N)C(C)(C)SSC[C@@H]2NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(=O)NCCCC[C@H](C(=O)NCC(N)=O)NC(=O)[C@H]3CCCN3C2=O)NC1=O | 10.1021/jm0303103 | |||
| 10030575 | 45952 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 554 | 5 | 2 | 4 | 3.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)NC1CN3CCC1CC3)C2 | 10.1021/jm00077a002 | |||
| CHEMBL132210 | 45952 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 554 | 5 | 2 | 4 | 3.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)NC1CN3CCC1CC3)C2 | 10.1021/jm00077a002 | |||
| 44351052 | 41259 | 0 | None | None | None | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 413 | 3 | 0 | 3 | 4.0 | CC1CN(S(=O)(=O)C[C@]23CCC(CC2=O)C3(C)C)CCC12C=Cc1ccccc12 | 10.1021/jm00099a020 | |||
| CHEMBL125748 | 41259 | 0 | None | None | None | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 413 | 3 | 0 | 3 | 4.0 | CC1CN(S(=O)(=O)C[C@]23CCC(CC2=O)C3(C)C)CCC12C=Cc1ccccc12 | 10.1021/jm00099a020 | |||
| 44352123 | 236918 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 566 | 8 | 3 | 6 | 1.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(N)CCS(N)(=O)=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL340639 | 236918 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 566 | 8 | 3 | 6 | 1.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(N)CCS(N)(=O)=O)C2 | 10.1021/jm00077a002 | |||
| 16737617 | 197207 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 1053 | 17 | 11 | 14 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | |||
| 16737618 | 197207 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 1053 | 17 | 11 | 14 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | |||
| CHEMBL265630 | 197207 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 1053 | 17 | 11 | 14 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | |||
| CHEMBL415418 | 197207 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 1053 | 17 | 11 | 14 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | |||
| 10366192 | 235590 | 0 | None | None | None | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 444 | 4 | 1 | 3 | 3.6 | CC(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL337212 | 235590 | 0 | None | None | None | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 444 | 4 | 1 | 3 | 3.6 | CC(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| 44351229 | 232075 | 0 | None | None | None | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 401 | 3 | 1 | 3 | 3.6 | CC1(C)C2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@H](O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL338324 | 232075 | 0 | None | None | None | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 401 | 3 | 1 | 3 | 3.6 | CC1(C)C2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@H](O)C2 | 10.1021/jm00099a020 | |||
| 44352433 | 236125 | 0 | None | None | None | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 622 | 10 | 3 | 7 | 1.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(CCS(C)(=O)=O)NC(=O)CN)C2 | 10.1021/jm00077a002 | |||
| CHEMBL339498 | 236125 | 0 | None | None | None | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 622 | 10 | 3 | 7 | 1.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(CCS(C)(=O)=O)NC(=O)CN)C2 | 10.1021/jm00077a002 | |||
| 10346739 | 235892 | 0 | None | None | None | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 524 | 5 | 0 | 5 | 3.3 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CN(CC#N)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL338984 | 235892 | 0 | None | None | None | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 524 | 5 | 0 | 5 | 3.3 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CN(CC#N)C1=O)C2 | 10.1021/jm00077a002 | |||
| 9893887 | 97049 | 2 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 554 | 9 | 2 | 7 | 1.5 | Cc1ccccc1N1CCN(S(=O)(=O)CC23CCC(C[C@@H]2NC(=O)[C@@H](N)CCS(C)(=O)=O)C3(C)C)CC1 | 10.1016/j.bmc.2020.115546 | |||
| CHEMBL154668 | 97049 | 2 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 554 | 9 | 2 | 7 | 1.5 | Cc1ccccc1N1CCN(S(=O)(=O)CC23CCC(C[C@@H]2NC(=O)[C@@H](N)CCS(C)(=O)=O)C3(C)C)CC1 | 10.1016/j.bmc.2020.115546 | |||
| 14981575 | 160372 | 0 | None | None | None | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 582 | 10 | 1 | 7 | 2.1 | Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)N(C)C)C3(C)C)CC1 | 10.1021/jm00031a004 | |||
| CHEMBL2112896 | 160372 | 0 | None | None | None | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 582 | 10 | 1 | 7 | 2.1 | Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@H](CCS(C)(=O)=O)N(C)C)C3(C)C)CC1 | 10.1021/jm00031a004 | |||
| 44352492 | 42827 | 0 | None | None | None | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 593 | 9 | 1 | 6 | 3.0 | CN(C)C(CCS(C)(=O)=O)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL128749 | 42827 | 0 | None | None | None | Rat | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 593 | 9 | 1 | 6 | 3.0 | CN(C)C(CCS(C)(=O)=O)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| 44429298 | 294154 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 1033 | 19 | 10 | 14 | -1.5 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3CCCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | |||
| CHEMBL393020 | 294154 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 1033 | 19 | 10 | 14 | -1.5 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3CCCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | |||
| 44273321 | 332274 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 542 | 7 | 2 | 6 | 2.2 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(NCCN)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL429971 | 332274 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 542 | 7 | 2 | 6 | 2.2 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(NCCN)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| 71449094 | 160290 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 581 | 8 | 3 | 7 | 1.3 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@](O)(CNC(=O)C(N)CS(C)(=O)=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL2112663 | 160290 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 581 | 8 | 3 | 7 | 1.3 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@](O)(CNC(=O)C(N)CS(C)(=O)=O)C2 | 10.1021/jm00077a002 | |||
| 9797987 | 237306 | 1 | None | None | None | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 339 | 2 | 0 | 2 | 3.7 | Cc1ccc(S(=O)(=O)N2CCC3(C=Cc4ccccc43)CC2)cc1 | 10.1021/jm00099a020 | |||
| CHEMBL341490 | 237306 | 1 | None | None | None | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 339 | 2 | 0 | 2 | 3.7 | Cc1ccc(S(=O)(=O)N2CCC3(C=Cc4ccccc43)CC2)cc1 | 10.1021/jm00099a020 | |||
| CHEMBL2112655 | 485105 | 0 | None | None | None | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 707 | 8 | 4 | 7 | 1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 10323799 | 235515 | 0 | None | None | None | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 502 | 7 | 2 | 4 | 3.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCC(=O)O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL336742 | 235515 | 0 | None | None | None | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 502 | 7 | 2 | 4 | 3.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCC(=O)O)C2 | 10.1021/jm00077a002 | |||
| 44352373 | 46150 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 543 | 8 | 3 | 5 | 3.4 | CC(C)C[C@H](N)C(=O)NC[C@@]1(O)C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL132389 | 46150 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 543 | 8 | 3 | 5 | 3.4 | CC(C)C[C@H](N)C(=O)NC[C@@]1(O)C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| 11757440 | 235803 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 556 | 7 | 1 | 5 | 3.7 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(CCC(=O)O)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL338503 | 235803 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 556 | 7 | 1 | 5 | 3.7 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(CCC(=O)O)C1=O)C2 | 10.1021/jm00077a002 | |||
| 44352374 | 42388 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 529 | 7 | 3 | 5 | 3.0 | CC(C)[C@H](N)C(=O)NC[C@@]1(O)C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL127445 | 42388 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 529 | 7 | 3 | 5 | 3.0 | CC(C)[C@H](N)C(=O)NC[C@@]1(O)C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| 44273034 | 199276 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 557 | 7 | 2 | 6 | 2.3 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(NCC(=O)O)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL280356 | 199276 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 557 | 7 | 2 | 6 | 2.3 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(NCC(=O)O)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL340204 | 487025 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 807 | 10 | 4 | 7 | 3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 44352431 | 42762 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 538 | 7 | 3 | 5 | 3.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)Cc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL128417 | 42762 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 538 | 7 | 3 | 5 | 3.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)Cc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| 10257352 | 160035 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 565 | 8 | 2 | 6 | 2.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](N)CCS(C)(=O)=O)C2 | 10.1021/jm00077a002 | |||
| 10483039 | 160035 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 565 | 8 | 2 | 6 | 2.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](N)CCS(C)(=O)=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL2111851 | 160035 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 565 | 8 | 2 | 6 | 2.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](N)CCS(C)(=O)=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL2112666 | 160035 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 565 | 8 | 2 | 6 | 2.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](N)CCS(C)(=O)=O)C2 | 10.1021/jm00077a002 | |||
| 10347314 | 235801 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 542 | 8 | 2 | 4 | 4.9 | CCC(C)(C)C(=O)NCC[C@@]1(O)C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL338499 | 235801 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 542 | 8 | 2 | 4 | 4.9 | CCC(C)(C)C(=O)NCC[C@@]1(O)C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| 44352443 | 237270 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 539 | 7 | 3 | 5 | 2.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](N)Cc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL341311 | 237270 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 539 | 7 | 3 | 5 | 2.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](N)Cc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| 44352299 | 235691 | 0 | None | None | None | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 416 | 3 | 1 | 4 | 4.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)/C(=N\O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL337842 | 235691 | 0 | None | None | None | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 416 | 3 | 1 | 4 | 4.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)/C(=N\O)C2 | 10.1021/jm00077a002 | |||
| 44351210 | 236156 | 0 | None | None | None | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 557 | 3 | 0 | 3 | 5.0 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CC1)c1ccccc1C(Br)C3Br)C(=O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL339698 | 236156 | 0 | None | None | None | Rat | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 557 | 3 | 0 | 3 | 5.0 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CC1)c1ccccc1C(Br)C3Br)C(=O)C2 | 10.1021/jm00099a020 | |||
| 44352124 | 235916 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 512 | 7 | 2 | 5 | 3.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(N)CCC#N)C2 | 10.1021/jm00077a002 | |||
| CHEMBL339124 | 235916 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 512 | 7 | 2 | 5 | 3.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(N)CCC#N)C2 | 10.1021/jm00077a002 | |||
| 44351215 | 236562 | 0 | None | None | None | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 477 | 4 | 1 | 3 | 5.1 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(c1ccccc1)C2 | 10.1021/jm00099a020 | |||
| CHEMBL340153 | 236562 | 0 | None | None | None | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 477 | 4 | 1 | 3 | 5.1 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(c1ccccc1)C2 | 10.1021/jm00099a020 | |||
| 10321314 | 236561 | 0 | None | None | None | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 445 | 4 | 2 | 3 | 3.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(N)=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL340150 | 236561 | 0 | None | None | None | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 445 | 4 | 2 | 3 | 3.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(N)=O)C2 | 10.1021/jm00077a002 | |||
| 10030575 | 45952 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 554 | 5 | 2 | 4 | 3.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)NC1CN3CCC1CC3)C2 | 10.1021/jm00077a002 | |||
| CHEMBL132210 | 45952 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 554 | 5 | 2 | 4 | 3.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)NC1CN3CCC1CC3)C2 | 10.1021/jm00077a002 | |||
| 44351034 | 232074 | 0 | None | None | None | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 401 | 3 | 1 | 3 | 3.6 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@H](O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL338318 | 232074 | 0 | None | None | None | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 401 | 3 | 1 | 3 | 3.6 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@H](O)C2 | 10.1021/jm00099a020 | |||
| 10046632 | 232009 | 0 | None | None | None | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 401 | 3 | 1 | 3 | 3.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@H](O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL334953 | 232009 | 0 | None | None | None | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 401 | 3 | 1 | 3 | 3.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@H](O)C2 | 10.1021/jm00077a002 | |||
| 10370147 | 42713 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 543 | 6 | 1 | 5 | 2.8 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CN(CC(=O)O)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL128163 | 42713 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 543 | 6 | 1 | 5 | 2.8 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CN(CC(=O)O)C1=O)C2 | 10.1021/jm00077a002 | |||
| 10369550 | 237275 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 524 | 6 | 1 | 5 | 3.6 | Cn1cncc1CC(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL341338 | 237275 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 524 | 6 | 1 | 5 | 3.6 | Cn1cncc1CC(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| 44352473 | 236077 | 0 | None | None | None | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 606 | 7 | 2 | 4 | 5.7 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)CC13CC4CC(CC(C4)C1)C3)C2 | 10.1021/jm00077a002 | |||
| CHEMBL339464 | 236077 | 0 | None | None | None | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 606 | 7 | 2 | 4 | 5.7 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)CC13CC4CC(CC(C4)C1)C3)C2 | 10.1021/jm00077a002 | |||
| 44429303 | 294155 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 1007 | 20 | 11 | 14 | -1.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | |||
| CHEMBL393021 | 294155 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 1007 | 20 | 11 | 14 | -1.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | |||
| 44352171 | 44665 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 565 | 7 | 2 | 5 | 3.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)C1=CCC(=O)N=C1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL130993 | 44665 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 565 | 7 | 2 | 5 | 3.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)C1=CCC(=O)N=C1)C2 | 10.1021/jm00077a002 | |||
| 44352442 | 328436 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 567 | 8 | 2 | 5 | 3.5 | CN(C)[C@H](Cc1c[nH]cn1)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL419973 | 328436 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 567 | 8 | 2 | 5 | 3.5 | CN(C)[C@H](Cc1c[nH]cn1)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| 10460610 | 337143 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 567 | 6 | 1 | 7 | 2.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CN(Cc3nn[nH]n3)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL449399 | 337143 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 567 | 6 | 1 | 7 | 2.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CN(Cc3nn[nH]n3)C1=O)C2 | 10.1021/jm00077a002 | |||
| 9986160 | 236217 | 0 | None | None | None | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 608 | 7 | 2 | 6 | 3.1 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CN(CC(=O)Nc3ncc[nH]3)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL339768 | 236217 | 0 | None | None | None | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 608 | 7 | 2 | 6 | 3.1 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CN(CC(=O)Nc3ncc[nH]3)C1=O)C2 | 10.1021/jm00077a002 | |||
| 44352347 | 235693 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 540 | 6 | 4 | 7 | 2.1 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)c1n[nH]c(N)n1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL337853 | 235693 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 540 | 6 | 4 | 7 | 2.1 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)c1n[nH]c(N)n1)C2 | 10.1021/jm00077a002 | |||
| 11757133 | 235813 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 543 | 6 | 2 | 5 | 2.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(CC(=O)O)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL338548 | 235813 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 543 | 6 | 2 | 5 | 2.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(CC(=O)O)C1=O)C2 | 10.1021/jm00077a002 | |||
| 44352146 | 236069 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 513 | 5 | 2 | 5 | 2.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CN1C(=O)CNC1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL339433 | 236069 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 513 | 5 | 2 | 5 | 2.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CN1C(=O)CNC1=O)C2 | 10.1021/jm00077a002 | |||
| 10258572 | 236926 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 638 | 11 | 4 | 6 | 2.3 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CC(CC(N)=O)NC(=O)Cc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL340676 | 236926 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 638 | 11 | 4 | 6 | 2.3 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CC(CC(N)=O)NC(=O)Cc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| 44342185 | 24364 | 0 | None | None | None | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 456 | 6 | 0 | 8 | 5.0 | COc1c([C@H](CC(C)C)OC(C)=O)ccc2c1C(=O)OCc1cc(C)cc(OC(C)=O)c1O2 | 10.1016/S0960-894X(01)80905-7 | |||
| CHEMBL115277 | 24364 | 0 | None | None | None | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 456 | 6 | 0 | 8 | 5.0 | COc1c([C@H](CC(C)C)OC(C)=O)ccc2c1C(=O)OCc1cc(C)cc(OC(C)=O)c1O2 | 10.1016/S0960-894X(01)80905-7 | |||
| 10357626 | 237215 | 0 | None | None | None | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 303 | 2 | 0 | 1 | 3.8 | O=C(Cc1ccccc1)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| CHEMBL341077 | 237215 | 0 | None | None | None | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 303 | 2 | 0 | 1 | 3.8 | O=C(Cc1ccccc1)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| 44429288 | 178241 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 1081 | 19 | 10 | 14 | -0.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | |||
| 44429290 | 178241 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 1081 | 19 | 10 | 14 | -0.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | |||
| CHEMBL233328 | 178241 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 1081 | 19 | 10 | 14 | -0.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | |||
| CHEMBL234377 | 178241 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 1081 | 19 | 10 | 14 | -0.9 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | |||
| CHEMBL415417 | 488399 | 0 | None | None | None | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 1022 | 16 | 13 | 15 | -3.1 | CC(C)C[C@H](NC(=O)[C@H](NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(C)(C)C)C(=O)NCC(N)=O | 10.1016/j.ejmech.2006.12.016 | |||
| 172997 | 4754 | 54 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 473 | 3 | 1 | 3 | 6.1 | Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C | 10.1016/j.bmcl.2007.08.053 | |||
| 2238 | 4754 | 54 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 473 | 3 | 1 | 3 | 6.1 | Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C | 10.1016/j.bmcl.2007.08.053 | |||
| CHEMBL49429 | 4754 | 54 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 473 | 3 | 1 | 3 | 6.1 | Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C | 10.1016/j.bmcl.2007.08.053 | |||
| DB06666 | 4754 | 54 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 473 | 3 | 1 | 3 | 6.1 | Fc1ccc(c(c1)C(=O)Nc1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2)C | 10.1016/j.bmcl.2007.08.053 | |||
| 10436379 | 155022 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 510 | 6 | 2 | 4 | 3.6 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1c[nH]cn1)C2 | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL20230 | 155022 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 510 | 6 | 2 | 4 | 3.6 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1c[nH]cn1)C2 | 10.1016/0960-894X(94)00469-V | |||
| 10413997 | 4534 | 5 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 510 | 6 | 2 | 4 | 3.6 | O=C(Cc1cnc[nH]1)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCC2(CC1)CCc1c2cccc1)(C)C | 10.1021/jm00077a002 | |||
| 2246 | 4534 | 5 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 510 | 6 | 2 | 4 | 3.6 | O=C(Cc1cnc[nH]1)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCC2(CC1)CCc1c2cccc1)(C)C | 10.1021/jm00077a002 | |||
| CHEMBL338522 | 4534 | 5 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 510 | 6 | 2 | 4 | 3.6 | O=C(Cc1cnc[nH]1)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCC2(CC1)CCc1c2cccc1)(C)C | 10.1021/jm00077a002 | |||
| 44352413 | 45311 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 549 | 7 | 2 | 5 | 3.7 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)Cc1cccnc1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL131551 | 45311 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 549 | 7 | 2 | 5 | 3.7 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)Cc1cccnc1)C2 | 10.1021/jm00077a002 | |||
| 10052855 | 235532 | 0 | None | None | None | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 534 | 7 | 1 | 3 | 5.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCc1ccccc1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL336857 | 235532 | 0 | None | None | None | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 534 | 7 | 1 | 3 | 5.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCc1ccccc1)C2 | 10.1021/jm00077a002 | |||
| 44352491 | 237052 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 549 | 8 | 2 | 5 | 2.7 | C[S+]([O-])CCC(N)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL340915 | 237052 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 549 | 8 | 2 | 5 | 2.7 | C[S+]([O-])CCC(N)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL127056 | 484595 | 0 | None | None | None | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 726 | 6 | 2 | 6 | 2.7 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCN2C1=O | 10.1021/jm00099a019 | |||
| 10046625 | 333106 | 0 | None | None | None | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 401 | 5 | 0 | 4 | 3.5 | CCOC(=O)C1(c2ccccc2)CCN(S(=O)(=O)c2ccc(C)cc2)CC1C | 10.1021/jm00099a020 | |||
| CHEMBL434825 | 333106 | 0 | None | None | None | Rat | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 401 | 5 | 0 | 4 | 3.5 | CCOC(=O)C1(c2ccccc2)CCN(S(=O)(=O)c2ccc(C)cc2)CC1C | 10.1021/jm00099a020 | |||
| 44429304 | 178138 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 1062 | 19 | 10 | 14 | -0.7 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)N3CCCC[C@@H]3C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | |||
| CHEMBL233080 | 178138 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 1062 | 19 | 10 | 14 | -0.7 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)N3CCCC[C@@H]3C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | |||
| 10075696 | 44357 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 530 | 8 | 3 | 5 | 2.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](N)CCC(N)=O)C2 | 10.1021/jm00077a002 | |||
| 10256467 | 44357 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 530 | 8 | 3 | 5 | 2.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](N)CCC(N)=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL130742 | 44357 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 530 | 8 | 3 | 5 | 2.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](N)CCC(N)=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL131650 | 44357 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 530 | 8 | 3 | 5 | 2.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](N)CCC(N)=O)C2 | 10.1021/jm00077a002 | |||
| 44351092 | 42089 | 0 | None | None | None | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 419 | 3 | 1 | 3 | 3.7 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4cc(F)ccc43)CC1)[C@H](O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL127016 | 42089 | 0 | None | None | None | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 419 | 3 | 1 | 3 | 3.7 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4cc(F)ccc43)CC1)[C@H](O)C2 | 10.1021/jm00099a020 | |||
| 44351219 | 235950 | 0 | None | None | None | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 419 | 3 | 1 | 3 | 3.7 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccc(F)cc43)CC1)[C@H](O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL339302 | 235950 | 0 | None | None | None | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 419 | 3 | 1 | 3 | 3.7 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccc(F)cc43)CC1)[C@H](O)C2 | 10.1021/jm00099a020 | |||
| 44352392 | 235739 | 0 | None | None | None | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 567 | 6 | 2 | 5 | 3.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)C1CN3CCC1CC3)C2 | 10.1021/jm00077a002 | |||
| CHEMBL338118 | 235739 | 0 | None | None | None | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 567 | 6 | 2 | 5 | 3.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)C1CN3CCC1CC3)C2 | 10.1021/jm00077a002 | |||
| 9984984 | 235797 | 0 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 548 | 8 | 1 | 3 | 5.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCCc1ccccc1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL338490 | 235797 | 0 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 548 | 8 | 1 | 3 | 5.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCCc1ccccc1)C2 | 10.1021/jm00077a002 | |||
| 9974603 | 42230 | 0 | None | None | None | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 341 | 2 | 0 | 2 | 3.7 | Cc1ccc(S(=O)(=O)N2CCC3(CCc4ccccc43)CC2)cc1 | 10.1021/jm00099a020 | |||
| CHEMBL127117 | 42230 | 0 | None | None | None | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 341 | 2 | 0 | 2 | 3.7 | Cc1ccc(S(=O)(=O)N2CCC3(CCc4ccccc43)CC2)cc1 | 10.1021/jm00099a020 | |||
| 44352428 | 236001 | 0 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 515 | 7 | 2 | 4 | 4.0 | CC(C)C[C@@H](N)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL339366 | 236001 | 0 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 515 | 7 | 2 | 4 | 4.0 | CC(C)C[C@@H](N)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| 44350978 | 41552 | 0 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 415 | 3 | 1 | 3 | 3.8 | C[C@@H]1C2CC[C@@](CS(=O)(=O)N3CCC4(C=Cc5ccccc54)CC3)([C@H]1O)C2(C)C | 10.1021/jm00099a020 | |||
| CHEMBL125847 | 41552 | 0 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 415 | 3 | 1 | 3 | 3.8 | C[C@@H]1C2CC[C@@](CS(=O)(=O)N3CCC4(C=Cc5ccccc54)CC3)([C@H]1O)C2(C)C | 10.1021/jm00099a020 | |||
| CHEMBL2112248 | 485096 | 0 | None | None | None | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 754 | 6 | 5 | 8 | 1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCC=NN2C1=O | 10.1021/jm00099a019 | |||
| 11764606 | 236211 | 0 | None | None | None | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 630 | 9 | 0 | 7 | 3.3 | Cn1cnc(CC(=O)N(CCS(C)(=O)=O)[C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)c1 | 10.1021/jm00077a002 | |||
| CHEMBL339756 | 236211 | 0 | None | None | None | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 630 | 9 | 0 | 7 | 3.3 | Cn1cnc(CC(=O)N(CCS(C)(=O)=O)[C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)c1 | 10.1021/jm00077a002 | |||
| 10258045 | 42728 | 0 | None | None | None | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 601 | 11 | 4 | 6 | 1.7 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CCN)C2 | 10.1021/jm00077a002 | |||
| CHEMBL128219 | 42728 | 0 | None | None | None | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 601 | 11 | 4 | 6 | 1.7 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CCN)C2 | 10.1021/jm00077a002 | |||
| 10461149 | 236130 | 0 | None | None | None | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 596 | 7 | 4 | 8 | 2.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(CNc3n[nH]c(N)n3)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL339524 | 236130 | 0 | None | None | None | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 596 | 7 | 4 | 8 | 2.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)NC(CNc3n[nH]c(N)n3)C1=O)C2 | 10.1021/jm00077a002 | |||
| 10324965 | 43404 | 0 | None | None | None | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 538 | 6 | 1 | 5 | 4.1 | CC(C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C)c1cn(C)cn1 | 10.1021/jm00077a002 | |||
| CHEMBL129971 | 43404 | 0 | None | None | None | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 538 | 6 | 1 | 5 | 4.1 | CC(C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C)c1cn(C)cn1 | 10.1021/jm00077a002 | |||
| 10480543 | 235438 | 0 | None | None | None | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 485 | 4 | 1 | 4 | 3.1 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1CCC(N)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL336195 | 235438 | 0 | None | None | None | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 485 | 4 | 1 | 4 | 3.1 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1CCC(N)C1=O)C2 | 10.1021/jm00077a002 | |||
| 44351264 | 43219 | 0 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 415 | 3 | 1 | 3 | 4.0 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@](C)(O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL129104 | 43219 | 0 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 415 | 3 | 1 | 3 | 4.0 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@](C)(O)C2 | 10.1021/jm00099a020 | |||
| 10021111 | 41849 | 3 | None | None | None | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 355 | 3 | 0 | 3 | 3.4 | COc1ccc(S(=O)(=O)N2CCC3(C=Cc4ccccc43)CC2)cc1 | 10.1021/jm00099a020 | |||
| CHEMBL126195 | 41849 | 3 | None | None | None | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 355 | 3 | 0 | 3 | 3.4 | COc1ccc(S(=O)(=O)N2CCC3(C=Cc4ccccc43)CC2)cc1 | 10.1021/jm00099a020 | |||
| 10370127 | 42730 | 0 | None | None | None | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 542 | 6 | 2 | 5 | 2.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CN1CC[C@H](N)C1=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL128228 | 42730 | 0 | None | None | None | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 542 | 6 | 2 | 5 | 2.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CN1CC[C@H](N)C1=O)C2 | 10.1021/jm00077a002 | |||
| 10460052 | 45953 | 0 | None | None | None | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 544 | 8 | 2 | 5 | 2.3 | CN(C)CC(=O)NCC(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL132211 | 45953 | 0 | None | None | None | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 544 | 8 | 2 | 5 | 2.3 | CN(C)CC(=O)NCC(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| 10255857 | 236219 | 0 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 512 | 5 | 1 | 4 | 5.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)c1cccs1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL339783 | 236219 | 0 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 512 | 5 | 1 | 4 | 5.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)c1cccs1)C2 | 10.1021/jm00077a002 | |||
| 44351057 | 41967 | 0 | None | None | None | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 413 | 3 | 0 | 3 | 4.1 | Cc1cccc2c1C1(C=C2)CCN(S(=O)(=O)C[C@]23CCC(CC2=O)C3(C)C)CC1 | 10.1021/jm00099a020 | |||
| CHEMBL126824 | 41967 | 0 | None | None | None | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 413 | 3 | 0 | 3 | 4.1 | Cc1cccc2c1C1(C=C2)CCN(S(=O)(=O)C[C@]23CCC(CC2=O)C3(C)C)CC1 | 10.1021/jm00099a020 | |||
| 44351155 | 43299 | 0 | None | None | None | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 413 | 3 | 0 | 3 | 4.1 | Cc1cccc2c1C=CC21CCN(S(=O)(=O)C[C@]23CCC(CC2=O)C3(C)C)CC1 | 10.1021/jm00099a020 | |||
| CHEMBL129581 | 43299 | 0 | None | None | None | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 413 | 3 | 0 | 3 | 4.1 | Cc1cccc2c1C=CC21CCN(S(=O)(=O)C[C@]23CCC(CC2=O)C3(C)C)CC1 | 10.1021/jm00099a020 | |||
| 44351235 | 235755 | 0 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 429 | 4 | 1 | 3 | 4.3 | CC[C@@]1(O)CC2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C | 10.1021/jm00099a020 | |||
| CHEMBL338235 | 235755 | 0 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 429 | 4 | 1 | 3 | 4.3 | CC[C@@]1(O)CC2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C | 10.1021/jm00099a020 | |||
| 44273077 | 199110 | 0 | None | None | None | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 589 | 7 | 1 | 5 | 4.4 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](NCc3ccccc3)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| 44273316 | 199110 | 0 | None | None | None | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 589 | 7 | 1 | 5 | 4.4 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](NCc3ccccc3)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL279022 | 199110 | 0 | None | None | None | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 589 | 7 | 1 | 5 | 4.4 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](NCc3ccccc3)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL281361 | 199110 | 0 | None | None | None | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 589 | 7 | 1 | 5 | 4.4 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@@H](NCc3ccccc3)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| 15011336 | 43241 | 0 | None | None | None | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 359 | 3 | 0 | 3 | 3.1 | O=C1CCCCC1CS(=O)(=O)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| CHEMBL129246 | 43241 | 0 | None | None | None | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 359 | 3 | 0 | 3 | 3.1 | O=C1CCCCC1CS(=O)(=O)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| CHEMBL419793 | 488423 | 0 | None | None | None | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 796 | 10 | 5 | 7 | 2.8 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCCN)NC(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 10098332 | 46276 | 0 | None | None | None | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 524 | 6 | 1 | 5 | 3.6 | Cn1cnc(CC(=O)N[C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)c1 | 10.1021/jm00077a002 | |||
| CHEMBL132496 | 46276 | 0 | None | None | None | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 524 | 6 | 1 | 5 | 3.6 | Cn1cnc(CC(=O)N[C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)c1 | 10.1021/jm00077a002 | |||
| 44352189 | 237299 | 0 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 414 | 3 | 1 | 4 | 4.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)/C(=N\O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL341470 | 237299 | 0 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 414 | 3 | 1 | 4 | 4.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)/C(=N\O)C2 | 10.1021/jm00077a002 | |||
| 10414067 | 333194 | 0 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 512 | 5 | 1 | 3 | 5.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C1CCCCC1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL435398 | 333194 | 0 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 512 | 5 | 1 | 3 | 5.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C1CCCCC1)C2 | 10.1021/jm00077a002 | |||
| 44351192 | 236892 | 0 | None | None | None | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 430 | 3 | 0 | 4 | 2.7 | CN1C(=O)C2(CCN(S(=O)(=O)C[C@]34CCC(CC3=O)C4(C)C)CC2)c2ccccc21 | 10.1021/jm00099a020 | |||
| CHEMBL340465 | 236892 | 0 | None | None | None | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 430 | 3 | 0 | 4 | 2.7 | CN1C(=O)C2(CCN(S(=O)(=O)C[C@]34CCC(CC3=O)C4(C)C)CC2)c2ccccc21 | 10.1021/jm00099a020 | |||
| 10363767 | 43388 | 0 | None | None | None | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 402 | 3 | 1 | 3 | 3.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@H](N)C2 | 10.1021/jm00077a002 | |||
| CHEMBL129955 | 43388 | 0 | None | None | None | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 402 | 3 | 1 | 3 | 3.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@H](N)C2 | 10.1021/jm00077a002 | |||
| CHEMBL129089 | 484604 | 0 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 754 | 6 | 2 | 6 | 3.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| CHEMBL338981 | 487006 | 0 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 726 | 6 | 2 | 6 | 2.7 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 124213 | 220165 | 18 | None | None | None | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 372 | 4 | 2 | 6 | 4.3 | COc1c([C@@H](O)CC(C)C)ccc2c1C(=O)OCc1cc(C)cc(O)c1O2 | 10.1016/S0960-894X(01)80905-7 | |||
| CHEMBL325752 | 220165 | 18 | None | None | None | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 372 | 4 | 2 | 6 | 4.3 | COc1c([C@@H](O)CC(C)C)ccc2c1C(=O)OCc1cc(C)cc(O)c1O2 | 10.1016/S0960-894X(01)80905-7 | |||
| 10324995 | 329279 | 0 | None | None | None | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 539 | 7 | 3 | 4 | 3.8 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)NCCc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL421248 | 329279 | 0 | None | None | None | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 539 | 7 | 3 | 4 | 3.8 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)NCCc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL395290 | 487787 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 1020 | 17 | 12 | 15 | -3.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | |||
| 44272997 | 143949 | 0 | None | None | None | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 499 | 4 | 1 | 5 | 2.6 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@H](N)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| 9805972 | 143949 | 0 | None | None | None | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 499 | 4 | 1 | 5 | 2.6 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@H](N)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL19658 | 143949 | 0 | None | None | None | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 499 | 4 | 1 | 5 | 2.6 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@H](N)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL276990 | 143949 | 0 | None | None | None | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 499 | 4 | 1 | 5 | 2.6 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)C[C@H](N)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| 44352455 | 333293 | 0 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 701 | 12 | 4 | 8 | 1.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)C(CCS(C)(=O)=O)NC(=O)Cc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL436189 | 333293 | 0 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 701 | 12 | 4 | 8 | 1.9 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)C(CCS(C)(=O)=O)NC(=O)Cc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| 9997556 | 237245 | 0 | None | None | None | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 343 | 2 | 0 | 2 | 3.6 | O=S(=O)(c1ccc(F)cc1)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| CHEMBL341108 | 237245 | 0 | None | None | None | Rat | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 343 | 2 | 0 | 2 | 3.6 | O=S(=O)(c1ccc(F)cc1)N1CCC2(C=Cc3ccccc32)CC1 | 10.1021/jm00099a020 | |||
| CHEMBL405289 | 487856 | 0 | None | None | None | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 755 | 7 | 5 | 7 | 2.1 | CCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| CHEMBL435159 | 488611 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 1068 | 17 | 12 | 15 | -2.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2Cc3ccccc3C[C@@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | |||
| 11758421 | 199862 | 0 | None | None | None | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 609 | 6 | 1 | 8 | 4.1 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cnc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL284442 | 199862 | 0 | None | None | None | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 609 | 6 | 1 | 8 | 4.1 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cnc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL395430 | 487790 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 994 | 18 | 13 | 15 | -3.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | |||
| 137357530 | 406425 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 508 | 3 | 0 | 7 | 5.0 | CC1c2nnc(C3CC4(C3)CN(c3ccc(F)cn3)C4)n2-c2ccc(Cl)cc2CN1C(=O)OC1CC1 | nan | |||
| CHEMBL5754963 | 406425 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 508 | 3 | 0 | 7 | 5.0 | CC1c2nnc(C3CC4(C3)CN(c3ccc(F)cn3)C4)n2-c2ccc(Cl)cc2CN1C(=O)OC1CC1 | nan | |||
| 137485061 | 409182 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 456 | 4 | 0 | 6 | 4.3 | FC(F)CN1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2ccccn2)C3)C1 | nan | |||
| CHEMBL5783103 | 409182 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 456 | 4 | 0 | 6 | 4.3 | FC(F)CN1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2ccccn2)C3)C1 | nan | |||
| 137485239 | 410767 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 482 | 2 | 0 | 7 | 4.5 | COC(=O)N1Cc2cc(Cl)ccc2-n2c(C3CC4(C3)CN(c3ncccc3F)C4)nnc2C1C | nan | |||
| CHEMBL5800135 | 410767 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 482 | 2 | 0 | 7 | 4.5 | COC(=O)N1Cc2cc(Cl)ccc2-n2c(C3CC4(C3)CN(c3ncccc3F)C4)nnc2C1C | nan | |||
| 137484963 | 412090 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 432 | 3 | 0 | 6 | 4.2 | Clc1ccc2c(c1)CN(C1CC1)Cc1nnc(C3CC4(C3)CN(c3ccccn3)C4)n1-2 | nan | |||
| CHEMBL5815032 | 412090 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 432 | 3 | 0 | 6 | 4.2 | Clc1ccc2c(c1)CN(C1CC1)Cc1nnc(C3CC4(C3)CN(c3ccccn3)C4)n1-2 | nan | |||
| 137485050 | 425997 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 464 | 3 | 0 | 6 | 4.7 | Fc1ccc(N2CC3(CC(c4nnc5n4-c4ccc(Cl)cc4CN(C4CCC4)C5)C3)C2)nc1 | nan | |||
| CHEMBL5859746 | 425997 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 464 | 3 | 0 | 6 | 4.7 | Fc1ccc(N2CC3(CC(c4nnc5n4-c4ccc(Cl)cc4CN(C4CCC4)C5)C3)C2)nc1 | nan | |||
| 137484954 | 429118 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 468 | 2 | 0 | 7 | 3.9 | COC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2ccc(F)cn2)C3)C1 | nan | |||
| CHEMBL5894664 | 429118 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 468 | 2 | 0 | 7 | 3.9 | COC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2ccc(F)cn2)C3)C1 | nan | |||
| 137485051 | 431213 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 479 | 3 | 0 | 8 | 4.1 | CCOC(=O)N1Cc2cc(Cl)ccc2-n2c(C3CC4(C3)CN(c3ncccn3)C4)nnc2C1C | nan | |||
| CHEMBL5915381 | 431213 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 479 | 3 | 0 | 8 | 4.1 | CCOC(=O)N1Cc2cc(Cl)ccc2-n2c(C3CC4(C3)CN(c3ncccn3)C4)nnc2C1C | nan | |||
| 137357380 | 431224 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 475 | 2 | 0 | 8 | 3.7 | COC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2cccc(C#N)n2)C3)C1 | nan | |||
| CHEMBL5915440 | 431224 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 475 | 2 | 0 | 8 | 3.7 | COC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2cccc(C#N)n2)C3)C1 | nan | |||
| 137357498 | 444583 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 482 | 2 | 0 | 7 | 4.5 | COC(=O)N1Cc2cc(Cl)ccc2-n2c(C3CC4(C3)CN(c3ccc(F)cn3)C4)nnc2C1C | nan | |||
| CHEMBL5952089 | 444583 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 482 | 2 | 0 | 7 | 4.5 | COC(=O)N1Cc2cc(Cl)ccc2-n2c(C3CC4(C3)CN(c3ccc(F)cn3)C4)nnc2C1C | nan | |||
| 137484931 | 446197 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 446 | 3 | 0 | 6 | 4.6 | Clc1ccc2c(c1)CN(C1CCC1)Cc1nnc(C3CC4(C3)CN(c3ccccn3)C4)n1-2 | nan | |||
| CHEMBL5969398 | 446197 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 446 | 3 | 0 | 6 | 4.6 | Clc1ccc2c(c1)CN(C1CCC1)Cc1nnc(C3CC4(C3)CN(c3ccccn3)C4)n1-2 | nan | |||
| 137485460 | 446378 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 464 | 3 | 0 | 6 | 4.6 | Cc1nc(N2CC3(CC(c4nnc5n4-c4ccc(Cl)cc4CN(C4CC4)C5)C3)C2)ccc1F | nan | |||
| CHEMBL5971402 | 446378 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 464 | 3 | 0 | 6 | 4.6 | Cc1nc(N2CC3(CC(c4nnc5n4-c4ccc(Cl)cc4CN(C4CC4)C5)C3)C2)ccc1F | nan | |||
| 137485233 | 446450 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 451 | 2 | 0 | 8 | 3.2 | COC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2ncccn2)C3)C1 | nan | |||
| CHEMBL5972042 | 446450 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 451 | 2 | 0 | 8 | 3.2 | COC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2ncccn2)C3)C1 | nan | |||
| 137357495 | 446566 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 429 | 1 | 0 | 6 | 4.0 | CN1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(C(=O)OC(C)(C)C)C3)C1 | nan | |||
| CHEMBL5973453 | 446566 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 429 | 1 | 0 | 6 | 4.0 | CN1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(C(=O)OC(C)(C)C)C3)C1 | nan | |||
| 137485262 | 446814 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 497 | 3 | 0 | 8 | 4.1 | CC(C)OC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2ncncc2F)C3)C1 | nan | |||
| CHEMBL5976554 | 446814 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 497 | 3 | 0 | 8 | 4.1 | CC(C)OC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2ncncc2F)C3)C1 | nan | |||
| 137485053 | 449039 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 510 | 3 | 0 | 6 | 4.7 | CC1c2nnc(C3CC4(C3)CN(c3ccc(F)cn3)C4)n2-c2ccc(Cl)cc2CN1C(=O)C1(F)CC1 | nan | |||
| CHEMBL6000224 | 449039 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 510 | 3 | 0 | 6 | 4.7 | CC1c2nnc(C3CC4(C3)CN(c3ccc(F)cn3)C4)n2-c2ccc(Cl)cc2CN1C(=O)C1(F)CC1 | nan | |||
| 137485028 | 450320 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 450 | 2 | 0 | 7 | 3.8 | COC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2ccccn2)C3)C1 | nan | |||
| CHEMBL6014034 | 450320 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 450 | 2 | 0 | 7 | 3.8 | COC(=O)N1Cc2cc(Cl)ccc2-n2c(nnc2C2CC3(C2)CN(c2ccccn2)C3)C1 | nan | |||
| 137485285 | 451043 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 505 | 3 | 0 | 8 | 4.7 | CC1c2nnc(C3CC4(C3)CN(c3ncccn3)C4)n2-c2ccc(Cl)cc2CN1C(=O)OC1(C)CC1 | nan | |||
| CHEMBL6021426 | 451043 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 505 | 3 | 0 | 8 | 4.7 | CC1c2nnc(C3CC4(C3)CN(c3ncccn3)C4)n2-c2ccc(Cl)cc2CN1C(=O)OC1(C)CC1 | nan | |||
| 137485308 | 464440 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 493 | 3 | 0 | 8 | 4.5 | CC(C)OC(=O)N1Cc2cc(Cl)ccc2-n2c(C3CC4(C3)CN(c3ncccn3)C4)nnc2C1C | nan | |||
| CHEMBL6059862 | 464440 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 493 | 3 | 0 | 8 | 4.5 | CC(C)OC(=O)N1Cc2cc(Cl)ccc2-n2c(C3CC4(C3)CN(c3ncccn3)C4)nnc2C1C | nan | |||
| 137485025 | 464610 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 465 | 2 | 0 | 8 | 3.7 | COC(=O)N1Cc2cc(Cl)ccc2-n2c(C3CC4(C3)CN(c3cnccn3)C4)nnc2C1C | nan | |||
| CHEMBL6061948 | 464610 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 465 | 2 | 0 | 8 | 3.7 | COC(=O)N1Cc2cc(Cl)ccc2-n2c(C3CC4(C3)CN(c3cnccn3)C4)nnc2C1C | nan | |||
| 44351004 | 43290 | 0 | None | None | None | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 363 | 2 | 0 | 2 | 4.4 | CC1(C)C2CC[C@@]1(CC(=O)N1CCC3(C=Cc4ccccc43)CC1)C(=O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL129513 | 43290 | 0 | None | None | None | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 363 | 2 | 0 | 2 | 4.4 | CC1(C)C2CC[C@@]1(CC(=O)N1CCC3(C=Cc4ccccc43)CC1)C(=O)C2 | 10.1021/jm00099a020 | |||
| 44351157 | 43050 | 0 | None | None | None | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 433 | 3 | 0 | 3 | 4.4 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4cc(Cl)ccc43)CC1)C(=O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL128978 | 43050 | 0 | None | None | None | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 433 | 3 | 0 | 3 | 4.4 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4cc(Cl)ccc43)CC1)C(=O)C2 | 10.1021/jm00099a020 | |||
| 44351065 | 236909 | 0 | None | None | None | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 433 | 3 | 0 | 3 | 4.4 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccc(Cl)cc43)CC1)C(=O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL340588 | 236909 | 0 | None | None | None | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 433 | 3 | 0 | 3 | 4.4 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccc(Cl)cc43)CC1)C(=O)C2 | 10.1021/jm00099a020 | |||
| 44351251 | 42149 | 0 | None | None | None | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 440 | 4 | 1 | 4 | 3.8 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CC#N)C2 | 10.1021/jm00099a020 | |||
| CHEMBL127049 | 42149 | 0 | None | None | None | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 440 | 4 | 1 | 4 | 3.8 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CC#N)C2 | 10.1021/jm00099a020 | |||
| 10026274 | 45268 | 0 | None | None | None | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 440 | 4 | 1 | 4 | 3.8 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CC#N)C2 | 10.1021/jm00077a002 | |||
| CHEMBL131499 | 45268 | 0 | None | None | None | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 440 | 4 | 1 | 4 | 3.8 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CC#N)C2 | 10.1021/jm00077a002 | |||
| 44351204 | 232099 | 3 | None | None | None | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 459 | 5 | 2 | 4 | 3.4 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CC(=O)O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL339681 | 232099 | 3 | None | None | None | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 459 | 5 | 2 | 4 | 3.4 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CC(=O)O)C2 | 10.1021/jm00099a020 | |||
| 44429300 | 177895 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 1035 | 18 | 11 | 14 | -1.3 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C(C)(C)C)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | |||
| CHEMBL232501 | 177895 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 1035 | 18 | 11 | 14 | -1.3 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)C(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C(C)(C)C)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | |||
| 10030443 | 235652 | 0 | None | None | None | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 549 | 7 | 2 | 5 | 4.1 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)c1ccncc1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL337615 | 235652 | 0 | None | None | None | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 549 | 7 | 2 | 5 | 4.1 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)c1ccncc1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL2369136 | 485404 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 1089 | 10 | 11 | 15 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H]([C@@H](C)c2c(C)cc(OC)cc2C)NC(=O)[C@H](N)C(C)(C)SSC[C@@H]2NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(=O)NCCCC[C@H](C(=O)NCC(N)=O)NC(=O)[C@H]3CCCN3C2=O)NC1=O | 10.1021/jm0303103 | |||
| CHEMBL2112250 | 485098 | 0 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 766 | 6 | 4 | 7 | 2.6 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 44352427 | 235700 | 0 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 637 | 10 | 4 | 6 | 3.2 | CC(C)[C@H](NC(=O)Cc1c[nH]cn1)C(=O)NC[C@@]1(O)C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL337889 | 235700 | 0 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 637 | 10 | 4 | 6 | 3.2 | CC(C)[C@H](NC(=O)Cc1c[nH]cn1)C(=O)NC[C@@]1(O)C[C@H]2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C | 10.1021/jm00077a002 | |||
| CHEMBL435021 | 488610 | 4 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 780 | 6 | 4 | 7 | 2.0 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CNCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 10437668 | 155157 | 1 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 554 | 9 | 2 | 7 | 1.5 | Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@@H](N)CCS(C)(=O)=O)C3(C)C)CC1 | 10.1021/jm00031a004 | |||
| CHEMBL2112903 | 155157 | 1 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 554 | 9 | 2 | 7 | 1.5 | Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CCC(C[C@@H]2NC(=O)[C@@H](N)CCS(C)(=O)=O)C3(C)C)CC1 | 10.1021/jm00031a004 | |||
| 2249 | 4540 | 14 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 554 | 9 | 2 | 7 | 1.5 | O=C([C@H](CCS(=O)(=O)C)N)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ccccc1C)(C)C | 10.1016/j.bmcl.2012.10.116 | |||
| 9872389 | 4540 | 14 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 554 | 9 | 2 | 7 | 1.5 | O=C([C@H](CCS(=O)(=O)C)N)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ccccc1C)(C)C | 10.1016/j.bmcl.2012.10.116 | |||
| CHEMBL1253853 | 4540 | 14 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 554 | 9 | 2 | 7 | 1.5 | O=C([C@H](CCS(=O)(=O)C)N)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ccccc1C)(C)C | 10.1016/j.bmcl.2012.10.116 | |||
| 44429295 | 333579 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 1110 | 19 | 10 | 14 | -0.1 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | |||
| CHEMBL438849 | 333579 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 1110 | 19 | 10 | 14 | -0.1 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@@H](C(=O)N3Cc4ccccc4C[C@@H]3C(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1016/j.ejmech.2006.12.016 | |||
| 44352114 | 45897 | 0 | None | None | None | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 517 | 8 | 3 | 5 | 2.7 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(N)CCCO)C2 | 10.1021/jm00077a002 | |||
| CHEMBL132165 | 45897 | 0 | None | None | None | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 517 | 8 | 3 | 5 | 2.7 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C(N)CCCO)C2 | 10.1021/jm00077a002 | |||
| 9981665 | 232117 | 5 | None | None | None | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 459 | 5 | 2 | 4 | 3.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CC(=O)O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL341339 | 232117 | 5 | None | None | None | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 459 | 5 | 2 | 4 | 3.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CC(=O)O)C2 | 10.1021/jm00077a002 | |||
| 44352400 | 42764 | 0 | None | None | None | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 549 | 7 | 2 | 5 | 3.7 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)Cc1ccccn1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL128423 | 42764 | 0 | None | None | None | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 549 | 7 | 2 | 5 | 3.7 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)Cc1ccccn1)C2 | 10.1021/jm00077a002 | |||
| 10413998 | 37968 | 0 | None | None | None | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 510 | 6 | 2 | 4 | 3.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@H](NC(=O)Cc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL128879 | 37968 | 0 | None | None | None | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 510 | 6 | 2 | 4 | 3.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@H](NC(=O)Cc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| 10341722 | 24663 | 4 | None | None | None | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 414 | 5 | 1 | 7 | 4.8 | COc1c([C@H](CC(C)C)OC(C)=O)ccc2c1C(=O)OCc1cc(C)cc(O)c1O2 | 10.1016/S0960-894X(01)80905-7 | |||
| CHEMBL116226 | 24663 | 4 | None | None | None | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 414 | 5 | 1 | 7 | 4.8 | COc1c([C@H](CC(C)C)OC(C)=O)ccc2c1C(=O)OCc1cc(C)cc(O)c1O2 | 10.1016/S0960-894X(01)80905-7 | |||
| 16736614 | 295716 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 975 | 16 | 10 | 13 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H]2Cc3ccccc3CN2C(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | |||
| CHEMBL394268 | 295716 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 975 | 16 | 10 | 13 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H]2Cc3ccccc3CN2C(=O)CCSSC[C@@H](C(=O)NC(C)(C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.ejmech.2006.12.016 | |||
| 44351033 | 41944 | 0 | None | None | None | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 475 | 4 | 0 | 3 | 5.2 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)C(c3ccccc3)C1)C(=O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL126708 | 41944 | 0 | None | None | None | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 475 | 4 | 0 | 3 | 5.2 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)C(c3ccccc3)C1)C(=O)C2 | 10.1021/jm00099a020 | |||
| 71456175 | 155132 | 0 | None | None | None | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 363 | 2 | 0 | 2 | 4.4 | CC1(C)C2CC[C@]1(CC(=O)N1CCC3(C=Cc4ccccc43)CC1)C(=O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL2111847 | 155132 | 0 | None | None | None | Rat | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 363 | 2 | 0 | 2 | 4.4 | CC1(C)C2CC[C@]1(CC(=O)N1CCC3(C=Cc4ccccc43)CC1)C(=O)C2 | 10.1021/jm00099a020 | |||
| CHEMBL2112654 | 485104 | 0 | None | None | None | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 716 | 6 | 4 | 7 | 1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 44351248 | 235785 | 0 | None | None | None | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 501 | 6 | 1 | 5 | 4.1 | CCOC(=O)C(C)[C@@]1(O)CC2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C | 10.1021/jm00099a020 | |||
| CHEMBL338409 | 235785 | 0 | None | None | None | Rat | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 501 | 6 | 1 | 5 | 4.1 | CCOC(=O)C(C)[C@@]1(O)CC2CC[C@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)C2(C)C | 10.1021/jm00099a020 | |||
| 44273013 | 199670 | 0 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 543 | 7 | 2 | 6 | 2.2 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(NCCO)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| CHEMBL283126 | 199670 | 0 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 543 | 7 | 2 | 6 | 2.2 | CC1(C)C2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](N1C(=O)CC(NCCO)C1=O)C2 | 10.1016/0960-894X(94)00469-V | |||
| 14981574 | 160374 | 0 | None | None | None | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 568 | 10 | 2 | 7 | 1.8 | CN[C@@H](CCS(C)(=O)=O)C(=O)N[C@H]1CC2CC[C@]1(CS(=O)(=O)N1CCN(c3ccccc3C)CC1)C2(C)C | 10.1021/jm00031a004 | |||
| CHEMBL2112898 | 160374 | 0 | None | None | None | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 568 | 10 | 2 | 7 | 1.8 | CN[C@@H](CCS(C)(=O)=O)C(=O)N[C@H]1CC2CC[C@]1(CS(=O)(=O)N1CCN(c3ccccc3C)CC1)C2(C)C | 10.1021/jm00031a004 | |||
| 10483105 | 174420 | 1 | None | None | None | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 568 | 10 | 2 | 7 | 1.8 | CN[C@@H](CCS(C)(=O)=O)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCN(c3ccccc3C)CC1)C2(C)C | 10.1016/j.bmcl.2012.10.116 | |||
| CHEMBL2391300 | 174420 | 1 | None | None | None | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 568 | 10 | 2 | 7 | 1.8 | CN[C@@H](CCS(C)(=O)=O)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCN(c3ccccc3C)CC1)C2(C)C | 10.1016/j.bmcl.2012.10.116 | |||
| 44352372 | 44491 | 0 | None | None | None | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 558 | 9 | 4 | 6 | 1.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)[C@@H](N)CCC(N)=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL130848 | 44491 | 0 | None | None | None | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 558 | 9 | 4 | 6 | 1.6 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CNC(=O)[C@@H](N)CCC(N)=O)C2 | 10.1021/jm00077a002 | |||
| 44352141 | 45297 | 0 | None | None | None | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 7 | 2 | 5 | 2.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](C(=O)[C@H](N)CC(N)=O)C2 | 10.1021/jm00077a002 | |||
| CHEMBL131538 | 45297 | 0 | None | None | None | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 501 | 7 | 2 | 5 | 2.5 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](C(=O)[C@H](N)CC(N)=O)C2 | 10.1021/jm00077a002 | |||
| 10347587 | 329938 | 0 | None | None | None | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 552 | 8 | 3 | 5 | 3.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)Cc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL422612 | 329938 | 0 | None | None | None | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 552 | 8 | 3 | 5 | 3.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)Cc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| 10030231 | 42775 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 541 | 6 | 1 | 4 | 4.5 | CC(C)CC1NC(=O)N([C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1021/jm00077a002 | |||
| CHEMBL128489 | 42775 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 541 | 6 | 1 | 4 | 4.5 | CC(C)CC1NC(=O)N([C@H]2C[C@H]3CC[C@]2(CS(=O)(=O)N2CCC4(CCc5ccccc54)CC2)C3(C)C)C1=O | 10.1021/jm00077a002 | |||
| 10097994 | 235191 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 514 | 5 | 3 | 4 | 2.3 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C1CNC(=O)N1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL335876 | 235191 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 514 | 5 | 3 | 4 | 2.3 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)C1CNC(=O)N1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL2112650 | 485102 | 0 | None | None | None | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 728 | 6 | 2 | 6 | 2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 10256281 | 42763 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 524 | 7 | 2 | 4 | 4.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL128422 | 42763 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 524 | 7 | 2 | 4 | 4.0 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)CCc1c[nH]cn1)C2 | 10.1021/jm00077a002 | |||
| 10414380 | 234995 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 521 | 6 | 1 | 4 | 4.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1ccccn1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL335634 | 234995 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 521 | 6 | 1 | 4 | 4.2 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(CCc4ccccc43)CC1)[C@@H](NC(=O)Cc1ccccn1)C2 | 10.1021/jm00077a002 | |||
| 10392781 | 237099 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 549 | 7 | 2 | 5 | 4.1 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)c1cccnc1)C2 | 10.1021/jm00077a002 | |||
| CHEMBL340964 | 237099 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 549 | 7 | 2 | 5 | 4.1 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CCNC(=O)c1cccnc1)C2 | 10.1021/jm00077a002 | |||
| 44350979 | 232109 | 0 | None | None | None | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 415 | 3 | 1 | 3 | 3.8 | C[C@H]1C2CC[C@@](CS(=O)(=O)N3CCC4(C=Cc5ccccc54)CC3)([C@@H]1O)C2(C)C | 10.1021/jm00099a020 | |||
| CHEMBL340237 | 232109 | 0 | None | None | None | Rat | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 415 | 3 | 1 | 3 | 3.8 | C[C@H]1C2CC[C@@](CS(=O)(=O)N3CCC4(C=Cc5ccccc54)CC3)([C@@H]1O)C2(C)C | 10.1021/jm00099a020 | |||
| 90663156 | 216271 | 0 | None | None | None | Human | 9.6 | pKd | = | 9.6 | Binding | ChEMBL | 1377 | 36 | 13 | 17 | 0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)CC1(SCCC(N)=O)CCCCC1)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc1ccc(N=[N+]=[N-])c(I)c1)C(N)=O)[C@@H](C)O | 10.1021/jm010125u | |||
| CHEMBL3142790 | 216271 | 0 | None | None | None | Human | 9.6 | pKd | = | 9.6 | Binding | ChEMBL | 1377 | 36 | 13 | 17 | 0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)CC1(SCCC(N)=O)CCCCC1)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc1ccc(N=[N+]=[N-])c(I)c1)C(N)=O)[C@@H](C)O | 10.1021/jm010125u | |||
| 136961688 | 237391 | 0 | None | 14 | 3 | Human | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | 1206 | 23 | 5 | 13 | 7.4 | CCN1/C(=C\C=C\C=C\C2=[N+](CC)c3cc(S(=O)(=O)[O-])ccc3C2(C)C)C(C)(CCCC(=O)NCCNC(=O)CCc2ccc(S(=O)(=O)N(CC(=O)N/N=C3\C(=O)Nc4ccccc43)c3ccc(Cl)cc3)cc2)c2cc(S(=O)(=O)O)ccc21 | 10.1021/jm501395b | |||
| CHEMBL3416750 | 237391 | 0 | None | 14 | 3 | Human | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | 1206 | 23 | 5 | 13 | 7.4 | CCN1/C(=C\C=C\C=C\C2=[N+](CC)c3cc(S(=O)(=O)[O-])ccc3C2(C)C)C(C)(CCCC(=O)NCCNC(=O)CCc2ccc(S(=O)(=O)N(CC(=O)N/N=C3\C(=O)Nc4ccccc43)c3ccc(Cl)cc3)cc2)c2cc(S(=O)(=O)O)ccc21 | 10.1021/jm501395b | |||
| 118753720 | 239499 | 0 | None | None | None | Human | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 1051 | 28 | 4 | 17 | 6.7 | COc1ccc(-n2c(COCCOCCOCCOCCNC(=O)CCCCCNC(=O)c3ccc(-c4c5ccc(=O)cc-5oc5cc(O)ccc45)c(C(=O)O)c3)nnc2N2CC(Oc3ccc(F)cc3Cl)C2)cn1 | 10.1021/jm501395b | |||
| CHEMBL3559144 | 239499 | 0 | None | None | None | Human | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 1051 | 28 | 4 | 17 | 6.7 | COc1ccc(-n2c(COCCOCCOCCOCCNC(=O)CCCCCNC(=O)c3ccc(-c4c5ccc(=O)cc-5oc5cc(O)ccc45)c(C(=O)O)c3)nnc2N2CC(Oc3ccc(F)cc3Cl)C2)cn1 | 10.1021/jm501395b | |||
| 145947419 | 332426 | 0 | None | 323 | 2 | Human | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 1204 | 30 | 2 | 18 | 7.6 | CCN1/C(=C\C=C\C=C\C2=[N+](CC)c3cc(S(=O)(=O)[O-])ccc3C2(C)C)C(C)(CCCC(=O)NCCOCCOCCOCCOCc2nnc(N3CC(Oc4ccc(F)cc4Cl)C3)n2-c2ccc(OC)nc2)c2cc(S(=O)(=O)O)ccc21 | 10.1021/jm501395b | |||
| CHEMBL4301807 | 332426 | 0 | None | 323 | 2 | Human | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 1204 | 30 | 2 | 18 | 7.6 | CCN1/C(=C\C=C\C=C\C2=[N+](CC)c3cc(S(=O)(=O)[O-])ccc3C2(C)C)C(C)(CCCC(=O)NCCOCCOCCOCCOCc2nnc(N3CC(Oc4ccc(F)cc4Cl)C3)n2-c2ccc(OC)nc2)c2cc(S(=O)(=O)O)ccc21 | 10.1021/jm501395b | |||
| 136961687 | 237390 | 0 | None | 35 | 3 | Human | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 1053 | 21 | 7 | 12 | 6.4 | O=C(CCCCCNC(=O)c1ccc(-c2c3ccc(=O)cc-3oc3cc(O)ccc23)c(C(=O)O)c1)NCCNC(=O)CCc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm501395b | |||
| CHEMBL3416749 | 237390 | 0 | None | 35 | 3 | Human | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 1053 | 21 | 7 | 12 | 6.4 | O=C(CCCCCNC(=O)c1ccc(-c2c3ccc(=O)cc-3oc3cc(O)ccc23)c(C(=O)O)c1)NCCNC(=O)CCc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm501395b | |||
| 145947801 | 332482 | 0 | None | 190 | 2 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 1381 | 42 | 2 | 22 | 7.7 | CCN1/C(=C\C=C\C=C\C2=[N+](CC)c3cc(S(=O)(=O)[O-])ccc3C2(C)C)C(C)(CCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCc2nnc(N3CC(Oc4ccc(F)cc4Cl)C3)n2-c2ccc(OC)nc2)c2cc(S(=O)(=O)O)ccc21 | 10.1021/jm501395b | |||
| CHEMBL4302530 | 332482 | 0 | None | 190 | 2 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 1381 | 42 | 2 | 22 | 7.7 | CCN1/C(=C\C=C\C=C\C2=[N+](CC)c3cc(S(=O)(=O)[O-])ccc3C2(C)C)C(C)(CCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCc2nnc(N3CC(Oc4ccc(F)cc4Cl)C3)n2-c2ccc(OC)nc2)c2cc(S(=O)(=O)O)ccc21 | 10.1021/jm501395b | |||
| 44324579 | 197358 | 0 | None | None | None | Rat | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 1157 | 31 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C(C)(C)S | 10.1021/jm00014a022 | |||
| CHEMBL266898 | 197358 | 0 | None | None | None | Rat | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 1157 | 31 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C(C)(C)S | 10.1021/jm00014a022 | |||
| 10011419 | 197335 | 0 | None | 1 | 3 | Rat | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 1092 | 17 | 11 | 13 | -1.0 | CC(C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| 44294474 | 197335 | 0 | None | 1 | 3 | Rat | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 1092 | 17 | 11 | 13 | -1.0 | CC(C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL266643 | 197335 | 0 | None | 1 | 3 | Rat | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 1092 | 17 | 11 | 13 | -1.0 | CC(C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3350125 | 197335 | 0 | None | 1 | 3 | Rat | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 1092 | 17 | 11 | 13 | -1.0 | CC(C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| 118718384 | 234321 | 0 | None | 7 | 3 | Rat | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 1154 | 18 | 12 | 16 | -0.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3349465 | 234321 | 0 | None | 7 | 3 | Rat | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 1154 | 18 | 12 | 16 | -0.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| 56671727 | 125949 | 0 | None | None | None | Rat | 5.0 | pKd | = | 5.0 | Binding | ChEMBL | 1101 | 29 | 15 | 14 | -2.5 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)[C@@H](C)O | 10.1021/jm00014a022 | |||
| CHEMBL1790762 | 125949 | 0 | None | None | None | Rat | 5.0 | pKd | = | 5.0 | Binding | ChEMBL | 1101 | 29 | 15 | 14 | -2.5 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)[C@@H](C)O | 10.1021/jm00014a022 | |||
| 90669116 | 219284 | 0 | None | 2 | 2 | Human | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 1019 | 17 | 11 | 14 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00187a002 | |||
| CHEMBL3229632 | 219284 | 0 | None | 2 | 2 | Human | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 1019 | 17 | 11 | 14 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00187a002 | |||
| 90669116 | 219284 | 0 | None | -2 | 2 | Rat | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 1019 | 17 | 11 | 14 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00200a007 | |||
| CHEMBL3229632 | 219284 | 0 | None | -2 | 2 | Rat | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 1019 | 17 | 11 | 14 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00200a007 | |||
| 90669121 | 219289 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1032 | 15 | 11 | 14 | -0.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00191a019 | |||
| CHEMBL3229637 | 219289 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1032 | 15 | 11 | 14 | -0.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00191a019 | |||
| 44324578 | 196924 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| 44324596 | 196924 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| 44324601 | 196924 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| 44324625 | 196924 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL263153 | 196924 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL268779 | 196924 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL386547 | 196924 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL439482 | 196924 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| 10463677 | 234323 | 4 | None | 38 | 3 | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 991 | 15 | 10 | 14 | -0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3349468 | 234323 | 4 | None | 38 | 3 | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 991 | 15 | 10 | 14 | -0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| 90669124 | 219292 | 0 | None | None | None | Rat | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 1048 | 18 | 11 | 15 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00191a019 | |||
| CHEMBL3229640 | 219292 | 0 | None | None | None | Rat | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 1048 | 18 | 11 | 15 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00191a019 | |||
| CHEMBL2370976 | 477420 | 13 | None | -2 | 3 | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1136 | 19 | 11 | 14 | -0.6 | CCOc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 | 10.1021/jm00010a020 | |||
| 71312201 | 234350 | 14 | None | 1 | 2 | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1074 | 19 | 11 | 15 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3350118 | 234350 | 14 | None | 1 | 2 | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1074 | 19 | 11 | 15 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| 118718750 | 234352 | 0 | None | -3 | 3 | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1151 | 19 | 12 | 15 | -2.3 | CN1C(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| 118718751 | 234352 | 0 | None | -3 | 3 | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1151 | 19 | 12 | 15 | -2.3 | CN1C(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| CHEMBL3350120 | 234352 | 0 | None | -3 | 3 | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1151 | 19 | 12 | 15 | -2.3 | CN1C(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| CHEMBL3350123 | 234352 | 0 | None | -3 | 3 | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1151 | 19 | 12 | 15 | -2.3 | CN1C(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| CHEMBL3245748 | 486666 | 1 | None | -4 | 3 | Human | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 1034 | 17 | 12 | 15 | -2.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)C(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00187a002 | |||
| CHEMBL3245748 | 486666 | 1 | None | -4 | 3 | Rat | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 1034 | 17 | 12 | 15 | -2.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)C(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00200a007 | |||
| 44324578 | 196924 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| 44324596 | 196924 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| 44324601 | 196924 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| 44324625 | 196924 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL263153 | 196924 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL268779 | 196924 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL386547 | 196924 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL439482 | 196924 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| 118718383 | 234320 | 0 | None | 66 | 3 | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1000 | 14 | 11 | 13 | 0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| 118718385 | 234320 | 0 | None | 66 | 3 | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1000 | 14 | 11 | 13 | 0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3349464 | 234320 | 0 | None | 66 | 3 | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1000 | 14 | 11 | 13 | 0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3349466 | 234320 | 0 | None | 66 | 3 | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1000 | 14 | 11 | 13 | 0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| 44320759 | 316382 | 0 | None | 8 | 2 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1036 | 22 | 12 | 15 | -4.4 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@H](C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1021/jm00028a008 | |||
| CHEMBL411420 | 316382 | 0 | None | 8 | 2 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1036 | 22 | 12 | 15 | -4.4 | CCOc1ccc(C[C@@H]2NC(=O)CCSSC[C@H](C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1021/jm00028a008 | |||
| 90669121 | 219289 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1032 | 15 | 11 | 14 | -0.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00191a019 | |||
| CHEMBL3229637 | 219289 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1032 | 15 | 11 | 14 | -0.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00191a019 | |||
| 90669122 | 219290 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1033 | 18 | 10 | 14 | -1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00191a019 | |||
| CHEMBL3229638 | 219290 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1033 | 18 | 10 | 14 | -1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00191a019 | |||
| 90669118 | 219286 | 0 | None | -1 | 2 | Rat | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 1047 | 19 | 11 | 14 | -1.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(CC)(CC)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00191a019 | |||
| CHEMBL3229634 | 219286 | 0 | None | -1 | 2 | Rat | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 1047 | 19 | 11 | 14 | -1.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(CC)(CC)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00191a019 | |||
| 90669123 | 219291 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1006 | 16 | 10 | 14 | -1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00191a019 | |||
| CHEMBL3229639 | 219291 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1006 | 16 | 10 | 14 | -1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00191a019 | |||
| 44324578 | 196924 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| 44324596 | 196924 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| 44324601 | 196924 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| 44324625 | 196924 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL263153 | 196924 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL268779 | 196924 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL386547 | 196924 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL439482 | 196924 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| 118718747 | 234349 | 0 | None | 1 | 2 | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1126 | 19 | 13 | 14 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| 118718748 | 234349 | 0 | None | 1 | 2 | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1126 | 19 | 13 | 14 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3350115 | 234349 | 0 | None | 1 | 2 | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1126 | 19 | 13 | 14 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3350116 | 234349 | 0 | None | 1 | 2 | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1126 | 19 | 13 | 14 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| 44320761 | 197170 | 0 | None | 1 | 2 | Human | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 1110 | 20 | 13 | 15 | -3.2 | CN(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C(=O)[C@H]1CSSC2(CCCCC2)CC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm00028a008 | |||
| 44321207 | 197170 | 0 | None | 1 | 2 | Human | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 1110 | 20 | 13 | 15 | -3.2 | CN(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C(=O)[C@H]1CSSC2(CCCCC2)CC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm00028a008 | |||
| CHEMBL265264 | 197170 | 0 | None | 1 | 2 | Human | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 1110 | 20 | 13 | 15 | -3.2 | CN(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C(=O)[C@H]1CSSC2(CCCCC2)CC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm00028a008 | |||
| CHEMBL384292 | 197170 | 0 | None | 1 | 2 | Human | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 1110 | 20 | 13 | 15 | -3.2 | CN(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C(=O)[C@H]1CSSC2(CCCCC2)CC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm00028a008 | |||
| CHEMBL3245750 | 486667 | 0 | None | None | None | Human | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 1019 | 16 | 11 | 14 | -1.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)C(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC1=O | 10.1021/jm00187a002 | |||
| 90669122 | 219290 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1033 | 18 | 10 | 14 | -1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00191a019 | |||
| CHEMBL3229638 | 219290 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1033 | 18 | 10 | 14 | -1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00191a019 | |||
| 44321134 | 222042 | 0 | None | 45 | 2 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 963 | 16 | 9 | 14 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@H]2C(=O)N(C)CC(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00028a008 | |||
| CHEMBL330022 | 222042 | 0 | None | 45 | 2 | Human | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 963 | 16 | 9 | 14 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@H]2C(=O)N(C)CC(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00028a008 | |||
| 10011419 | 197335 | 0 | None | 1 | 3 | Rat | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1092 | 17 | 11 | 13 | -1.0 | CC(C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| 44294474 | 197335 | 0 | None | 1 | 3 | Rat | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1092 | 17 | 11 | 13 | -1.0 | CC(C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL266643 | 197335 | 0 | None | 1 | 3 | Rat | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1092 | 17 | 11 | 13 | -1.0 | CC(C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3350125 | 197335 | 0 | None | 1 | 3 | Rat | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1092 | 17 | 11 | 13 | -1.0 | CC(C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| 118718386 | 234322 | 0 | None | 12 | 3 | Rat | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 991 | 14 | 10 | 14 | -0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3349467 | 234322 | 0 | None | 12 | 3 | Rat | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 991 | 14 | 10 | 14 | -0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| 90678222 | 220926 | 0 | None | None | None | Rat | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 1019 | 17 | 11 | 14 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSSCC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00224a010 | |||
| CHEMBL3273609 | 220926 | 0 | None | None | None | Rat | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 1019 | 17 | 11 | 14 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSSCC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00224a010 | |||
| 90669119 | 219287 | 0 | None | None | None | Rat | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1020 | 17 | 11 | 14 | -0.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(CC)(CC)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00191a019 | |||
| CHEMBL3229635 | 219287 | 0 | None | None | None | Rat | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1020 | 17 | 11 | 14 | -0.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(CC)(CC)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00191a019 | |||
| 70693566 | 159935 | 0 | None | 2 | 2 | Human | 5.7 | pKd | = | 5.7 | Binding | ChEMBL | 1018 | 18 | 12 | 14 | -4.5 | CC[C@H](C)[C@H]1NC(=O)[C@]2(CCc3ccccc3C2)NC(=O)CCSSC[C@H](C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/s0960-894x(99)00041-4 | |||
| CHEMBL2110297 | 159935 | 0 | None | 2 | 2 | Human | 5.7 | pKd | = | 5.7 | Binding | ChEMBL | 1018 | 18 | 12 | 14 | -4.5 | CC[C@H](C)[C@H]1NC(=O)[C@]2(CCc3ccccc3C2)NC(=O)CCSSC[C@H](C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/s0960-894x(99)00041-4 | |||
| 118753721 | 239500 | 0 | None | None | None | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 1227 | 40 | 4 | 21 | 6.8 | COc1ccc(-n2c(COCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCCCNC(=O)c3ccc(-c4c5ccc(=O)cc-5oc5cc(O)ccc45)c(C(=O)O)c3)nnc2N2CC(Oc3ccc(F)cc3Cl)C2)cn1 | 10.1021/jm501395b | |||
| CHEMBL3559145 | 239500 | 0 | None | None | None | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 1227 | 40 | 4 | 21 | 6.8 | COc1ccc(-n2c(COCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCCCNC(=O)c3ccc(-c4c5ccc(=O)cc-5oc5cc(O)ccc45)c(C(=O)O)c3)nnc2N2CC(Oc3ccc(F)cc3Cl)C2)cn1 | 10.1021/jm501395b | |||
| 44320718 | 333533 | 0 | None | 1 | 2 | Human | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1139 | 22 | 12 | 15 | -2.5 | CCOc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 | 10.1021/jm00028a008 | |||
| CHEMBL438387 | 333533 | 0 | None | 1 | 2 | Human | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1139 | 22 | 12 | 15 | -2.5 | CCOc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 | 10.1021/jm00028a008 | |||
| CHEMBL3350121 | 486861 | 0 | None | None | None | Rat | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)CC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](N)CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| 118718383 | 234320 | 0 | None | 66 | 3 | Rat | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1000 | 14 | 11 | 13 | 0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| 118718385 | 234320 | 0 | None | 66 | 3 | Rat | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1000 | 14 | 11 | 13 | 0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3349464 | 234320 | 0 | None | 66 | 3 | Rat | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1000 | 14 | 11 | 13 | 0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3349466 | 234320 | 0 | None | 66 | 3 | Rat | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1000 | 14 | 11 | 13 | 0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| 118718753 | 234353 | 0 | None | 1 | 3 | Rat | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1074 | 18 | 11 | 15 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3350126 | 234353 | 0 | None | 1 | 3 | Rat | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1074 | 18 | 11 | 15 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| 90669123 | 219291 | 0 | None | None | None | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1006 | 16 | 10 | 14 | -1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00191a019 | |||
| CHEMBL3229639 | 219291 | 0 | None | None | None | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1006 | 16 | 10 | 14 | -1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00191a019 | |||
| 118718383 | 234320 | 0 | None | 66 | 3 | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1000 | 14 | 11 | 13 | 0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| 118718385 | 234320 | 0 | None | 66 | 3 | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1000 | 14 | 11 | 13 | 0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3349464 | 234320 | 0 | None | 66 | 3 | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1000 | 14 | 11 | 13 | 0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3349466 | 234320 | 0 | None | 66 | 3 | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1000 | 14 | 11 | 13 | 0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| 10396464 | 234324 | 1 | None | 8 | 2 | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1154 | 19 | 12 | 16 | -0.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3349469 | 234324 | 1 | None | 8 | 2 | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1154 | 19 | 12 | 16 | -0.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| 90669116 | 219284 | 0 | None | -2 | 2 | Rat | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 1019 | 17 | 11 | 14 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00191a019 | |||
| CHEMBL3229632 | 219284 | 0 | None | -2 | 2 | Rat | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 1019 | 17 | 11 | 14 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00191a019 | |||
| 90669120 | 219288 | 1 | None | None | None | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1059 | 17 | 11 | 14 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00191a019 | |||
| CHEMBL3229636 | 219288 | 1 | None | None | None | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1059 | 17 | 11 | 14 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00191a019 | |||
| CHEMBL2372311 | 477732 | 6 | None | None | None | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1110 | 20 | 12 | 15 | -3.3 | COc1ccc(C[C@@H]2NC(=O)CC(C)(C)SSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 | 10.1021/jm00191a019 | |||
| 90669124 | 219292 | 0 | None | None | None | Rat | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 1048 | 18 | 11 | 15 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00191a019 | |||
| CHEMBL3229640 | 219292 | 0 | None | None | None | Rat | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 1048 | 18 | 11 | 15 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00191a019 | |||
| 118718750 | 234352 | 0 | None | -3 | 3 | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1151 | 19 | 12 | 15 | -2.3 | CN1C(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| 118718751 | 234352 | 0 | None | -3 | 3 | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1151 | 19 | 12 | 15 | -2.3 | CN1C(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| CHEMBL3350120 | 234352 | 0 | None | -3 | 3 | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1151 | 19 | 12 | 15 | -2.3 | CN1C(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| CHEMBL3350123 | 234352 | 0 | None | -3 | 3 | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1151 | 19 | 12 | 15 | -2.3 | CN1C(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| 118718386 | 234322 | 0 | None | 12 | 3 | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 991 | 14 | 10 | 14 | -0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3349467 | 234322 | 0 | None | 12 | 3 | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 991 | 14 | 10 | 14 | -0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| 90669117 | 219285 | 1 | None | None | None | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 992 | 15 | 11 | 14 | -1.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00200a007 | |||
| CHEMBL3229633 | 219285 | 1 | None | None | None | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 992 | 15 | 11 | 14 | -1.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00200a007 | |||
| 118718749 | 234351 | 0 | None | -1 | 3 | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1136 | 18 | 11 | 14 | -0.5 | CCN1C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| 118718752 | 234351 | 0 | None | -1 | 3 | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1136 | 18 | 11 | 14 | -0.5 | CCN1C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| CHEMBL3350119 | 234351 | 0 | None | -1 | 3 | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1136 | 18 | 11 | 14 | -0.5 | CCN1C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| CHEMBL3350124 | 234351 | 0 | None | -1 | 3 | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1136 | 18 | 11 | 14 | -0.5 | CCN1C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| 56678404 | 126039 | 0 | None | -1 | 2 | Human | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 1060 | 20 | 12 | 14 | -3.1 | CC[C@H](C)[C@@H]1NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm00028a008 | |||
| CHEMBL1793955 | 126039 | 0 | None | -1 | 2 | Human | 6.6 | pKd | = | 6.6 | Binding | ChEMBL | 1060 | 20 | 12 | 14 | -3.1 | CC[C@H](C)[C@@H]1NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC1=O | 10.1021/jm00028a008 | |||
| 44321188 | 317415 | 0 | None | 1 | 2 | Human | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1105 | 22 | 12 | 15 | -2.7 | CCOc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@H](C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1021/jm00028a008 | |||
| CHEMBL415230 | 317415 | 0 | None | 1 | 2 | Human | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1105 | 22 | 12 | 15 | -2.7 | CCOc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@H](C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1021/jm00028a008 | |||
| 90669118 | 219286 | 0 | None | -1 | 2 | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1047 | 19 | 11 | 14 | -1.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(CC)(CC)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00191a019 | |||
| CHEMBL3229634 | 219286 | 0 | None | -1 | 2 | Rat | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 1047 | 19 | 11 | 14 | -1.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(CC)(CC)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00191a019 | |||
| 118718747 | 234349 | 0 | None | 1 | 2 | Rat | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 1126 | 19 | 13 | 14 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| 118718748 | 234349 | 0 | None | 1 | 2 | Rat | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 1126 | 19 | 13 | 14 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3350115 | 234349 | 0 | None | 1 | 2 | Rat | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 1126 | 19 | 13 | 14 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3350116 | 234349 | 0 | None | 1 | 2 | Rat | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 1126 | 19 | 13 | 14 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL2370976 | 477420 | 13 | None | -2 | 3 | Rat | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 1136 | 19 | 11 | 14 | -0.6 | CCOc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 | 10.1021/jm00010a020 | |||
| 71312201 | 234350 | 14 | None | 1 | 2 | Rat | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 1074 | 19 | 11 | 15 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3350118 | 234350 | 14 | None | 1 | 2 | Rat | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 1074 | 19 | 11 | 15 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| 90669117 | 219285 | 1 | None | None | None | Rat | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 992 | 15 | 11 | 14 | -1.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00191a019 | |||
| CHEMBL3229633 | 219285 | 1 | None | None | None | Rat | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 992 | 15 | 11 | 14 | -1.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00191a019 | |||
| 44324600 | 333609 | 0 | None | None | None | Rat | 5.5 | pKd | = | 5.5 | Binding | ChEMBL | 1157 | 32 | 16 | 14 | -2.4 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL439098 | 333609 | 0 | None | None | None | Rat | 5.5 | pKd | = | 5.5 | Binding | ChEMBL | 1157 | 32 | 16 | 14 | -2.4 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL3245748 | 486666 | 1 | None | 4 | 3 | Chicken | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 1034 | 17 | 12 | 15 | -2.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)C(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00201a017 | |||
| 90669117 | 219285 | 1 | None | None | None | Rat | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 992 | 15 | 11 | 14 | -1.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00187a002 | |||
| CHEMBL3229633 | 219285 | 1 | None | None | None | Rat | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 992 | 15 | 11 | 14 | -1.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00187a002 | |||
| 118718747 | 234349 | 0 | None | 1 | 2 | Rat | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 1126 | 19 | 13 | 14 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| 118718748 | 234349 | 0 | None | 1 | 2 | Rat | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 1126 | 19 | 13 | 14 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3350115 | 234349 | 0 | None | 1 | 2 | Rat | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 1126 | 19 | 13 | 14 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3350116 | 234349 | 0 | None | 1 | 2 | Rat | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 1126 | 19 | 13 | 14 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| 90669117 | 219285 | 1 | None | None | None | Rat | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 992 | 15 | 11 | 14 | -1.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00200a007 | |||
| CHEMBL3229633 | 219285 | 1 | None | None | None | Rat | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 992 | 15 | 11 | 14 | -1.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00200a007 | |||
| CHEMBL3229641 | 486644 | 0 | None | None | None | Rat | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1097 | 20 | 14 | 16 | -4.9 | COc1ccc(C[C@@H]2NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 | 10.1021/jm00191a019 | |||
| 118718753 | 234353 | 0 | None | 1 | 3 | Rat | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1074 | 18 | 11 | 15 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3350126 | 234353 | 0 | None | 1 | 3 | Rat | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1074 | 18 | 11 | 15 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| 70693557 | 159925 | 0 | None | 6 | 2 | Human | 6.4 | pKd | = | 6.4 | Binding | ChEMBL | 1018 | 18 | 12 | 14 | -4.5 | CC[C@H](C)[C@H]1NC(=O)[C@@]2(CCc3ccccc3C2)NC(=O)CCSSC[C@H](C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/s0960-894x(99)00041-4 | |||
| CHEMBL2110163 | 159925 | 0 | None | 6 | 2 | Human | 6.4 | pKd | = | 6.4 | Binding | ChEMBL | 1018 | 18 | 12 | 14 | -4.5 | CC[C@H](C)[C@H]1NC(=O)[C@@]2(CCc3ccccc3C2)NC(=O)CCSSC[C@H](C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/s0960-894x(99)00041-4 | |||
| 90669120 | 219288 | 1 | None | None | None | Rat | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1059 | 17 | 11 | 14 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00187a002 | |||
| CHEMBL3229636 | 219288 | 1 | None | None | None | Rat | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1059 | 17 | 11 | 14 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00187a002 | |||
| 90669120 | 219288 | 1 | None | None | None | Rat | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1059 | 17 | 11 | 14 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00200a007 | |||
| CHEMBL3229636 | 219288 | 1 | None | None | None | Rat | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1059 | 17 | 11 | 14 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00200a007 | |||
| 90669120 | 219288 | 1 | None | None | None | Rat | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1059 | 17 | 11 | 14 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00200a007 | |||
| CHEMBL3229636 | 219288 | 1 | None | None | None | Rat | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1059 | 17 | 11 | 14 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00200a007 | |||
| 118718749 | 234351 | 0 | None | -1 | 3 | Rat | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1136 | 18 | 11 | 14 | -0.5 | CCN1C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| 118718752 | 234351 | 0 | None | -1 | 3 | Rat | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1136 | 18 | 11 | 14 | -0.5 | CCN1C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| CHEMBL3350119 | 234351 | 0 | None | -1 | 3 | Rat | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1136 | 18 | 11 | 14 | -0.5 | CCN1C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| CHEMBL3350124 | 234351 | 0 | None | -1 | 3 | Rat | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1136 | 18 | 11 | 14 | -0.5 | CCN1C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| 44373715 | 311636 | 0 | None | 131 | 2 | Human | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1031 | 20 | 13 | 14 | -4.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CCSSC[C@@H](C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC1=O | 10.1016/s0960-894x(99)00041-4 | |||
| CHEMBL405165 | 311636 | 0 | None | 131 | 2 | Human | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1031 | 20 | 13 | 14 | -4.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CCSSC[C@@H](C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC1=O | 10.1016/s0960-894x(99)00041-4 | |||
| 118718384 | 234321 | 0 | None | 7 | 3 | Rat | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1154 | 18 | 12 | 16 | -0.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3349465 | 234321 | 0 | None | 7 | 3 | Rat | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1154 | 18 | 12 | 16 | -0.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| 44324574 | 197195 | 0 | None | None | None | Rat | 5.4 | pKd | = | 5.4 | Binding | ChEMBL | 1114 | 30 | 15 | 14 | -3.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL265490 | 197195 | 0 | None | None | None | Rat | 5.4 | pKd | = | 5.4 | Binding | ChEMBL | 1114 | 30 | 15 | 14 | -3.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL2370617 | 477411 | 0 | None | 1 | 3 | Rat | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 1136 | 19 | 11 | 14 | -0.6 | CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 | 10.1021/jm00010a020 | |||
| CHEMBL2370617 | 477411 | 0 | None | 1 | 3 | Rat | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1136 | 19 | 11 | 14 | -0.6 | CCOc1ccc(C[C@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 | 10.1021/jm00010a020 | |||
| 90669119 | 219287 | 0 | None | None | None | Rat | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1020 | 17 | 11 | 14 | -0.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(CC)(CC)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00191a019 | |||
| CHEMBL3229635 | 219287 | 0 | None | None | None | Rat | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1020 | 17 | 11 | 14 | -0.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(CC)(CC)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00191a019 | |||
| 10011419 | 197335 | 0 | None | 1 | 3 | Rat | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1092 | 17 | 11 | 13 | -1.0 | CC(C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| 44294474 | 197335 | 0 | None | 1 | 3 | Rat | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1092 | 17 | 11 | 13 | -1.0 | CC(C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL266643 | 197335 | 0 | None | 1 | 3 | Rat | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1092 | 17 | 11 | 13 | -1.0 | CC(C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3350125 | 197335 | 0 | None | 1 | 3 | Rat | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 1092 | 17 | 11 | 13 | -1.0 | CC(C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| 44324578 | 196924 | 0 | None | None | None | Rat | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| 44324596 | 196924 | 0 | None | None | None | Rat | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| 44324601 | 196924 | 0 | None | None | None | Rat | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| 44324625 | 196924 | 0 | None | None | None | Rat | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL263153 | 196924 | 0 | None | None | None | Rat | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL268779 | 196924 | 0 | None | None | None | Rat | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL386547 | 196924 | 0 | None | None | None | Rat | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL439482 | 196924 | 0 | None | None | None | Rat | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| 10011419 | 197335 | 0 | None | 1 | 3 | Rat | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1092 | 17 | 11 | 13 | -1.0 | CC(C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| 44294474 | 197335 | 0 | None | 1 | 3 | Rat | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1092 | 17 | 11 | 13 | -1.0 | CC(C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL266643 | 197335 | 0 | None | 1 | 3 | Rat | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1092 | 17 | 11 | 13 | -1.0 | CC(C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3350125 | 197335 | 0 | None | 1 | 3 | Rat | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1092 | 17 | 11 | 13 | -1.0 | CC(C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| 118718747 | 234349 | 0 | None | 1 | 2 | Rat | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1126 | 19 | 13 | 14 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| 118718748 | 234349 | 0 | None | 1 | 2 | Rat | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1126 | 19 | 13 | 14 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3350115 | 234349 | 0 | None | 1 | 2 | Rat | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1126 | 19 | 13 | 14 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3350116 | 234349 | 0 | None | 1 | 2 | Rat | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1126 | 19 | 13 | 14 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| 10396464 | 234324 | 1 | None | 8 | 2 | Rat | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1154 | 19 | 12 | 16 | -0.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3349469 | 234324 | 1 | None | 8 | 2 | Rat | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 1154 | 19 | 12 | 16 | -0.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| 10463677 | 234323 | 4 | None | 38 | 3 | Rat | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 991 | 15 | 10 | 14 | -0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3349468 | 234323 | 4 | None | 38 | 3 | Rat | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 991 | 15 | 10 | 14 | -0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| 90673598 | 220033 | 0 | None | None | None | Chicken | 7.3 | pKd | = | 7.3 | Binding | ChEMBL | 957 | 17 | 12 | 12 | -3.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)NCCCC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00201a017 | |||
| CHEMBL3249128 | 220033 | 0 | None | None | None | Chicken | 7.3 | pKd | = | 7.3 | Binding | ChEMBL | 957 | 17 | 12 | 12 | -3.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)NCCCC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00201a017 | |||
| 90669118 | 219286 | 0 | None | 1 | 2 | Human | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 1047 | 19 | 11 | 14 | -1.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(CC)(CC)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00187a002 | |||
| CHEMBL3229634 | 219286 | 0 | None | 1 | 2 | Human | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 1047 | 19 | 11 | 14 | -1.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(CC)(CC)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00187a002 | |||
| 118718749 | 234351 | 0 | None | -1 | 3 | Rat | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 1136 | 18 | 11 | 14 | -0.5 | CCN1C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| 118718752 | 234351 | 0 | None | -1 | 3 | Rat | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 1136 | 18 | 11 | 14 | -0.5 | CCN1C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| CHEMBL3350119 | 234351 | 0 | None | -1 | 3 | Rat | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 1136 | 18 | 11 | 14 | -0.5 | CCN1C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| CHEMBL3350124 | 234351 | 0 | None | -1 | 3 | Rat | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 1136 | 18 | 11 | 14 | -0.5 | CCN1C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| 118718750 | 234352 | 0 | None | -3 | 3 | Rat | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 1151 | 19 | 12 | 15 | -2.3 | CN1C(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| 118718751 | 234352 | 0 | None | -3 | 3 | Rat | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 1151 | 19 | 12 | 15 | -2.3 | CN1C(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| CHEMBL3350120 | 234352 | 0 | None | -3 | 3 | Rat | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 1151 | 19 | 12 | 15 | -2.3 | CN1C(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| CHEMBL3350123 | 234352 | 0 | None | -3 | 3 | Rat | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 1151 | 19 | 12 | 15 | -2.3 | CN1C(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| CHEMBL2371240 | 477685 | 0 | None | None | None | Human | 4.2 | pKd | = | 4.2 | Binding | ChEMBL | 1043 | 18 | 12 | 14 | -3.9 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2c3[nH]c4ccccc4c3CCN2C(=O)CCSSC[C@H](C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/s0960-894x(99)00041-4 | |||
| 44324577 | 196784 | 0 | None | None | None | Rat | 5.2 | pKd | = | 5.2 | Binding | ChEMBL | 1128 | 31 | 15 | 14 | -2.6 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL262157 | 196784 | 0 | None | None | None | Rat | 5.2 | pKd | = | 5.2 | Binding | ChEMBL | 1128 | 31 | 15 | 14 | -2.6 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL3350121 | 486861 | 0 | None | None | None | Rat | 5.2 | pKd | = | 5.2 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)CC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](N)CSSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm00010a020 | |||
| 90669117 | 219285 | 1 | None | None | None | Rat | 6.2 | pKd | = | 6.2 | Binding | ChEMBL | 992 | 15 | 11 | 14 | -1.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00191a019 | |||
| CHEMBL3229633 | 219285 | 1 | None | None | None | Rat | 6.2 | pKd | = | 6.2 | Binding | ChEMBL | 992 | 15 | 11 | 14 | -1.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00191a019 | |||
| 44324597 | 197562 | 0 | None | None | None | Rat | 5.2 | pKd | = | 5.2 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@@H](C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL268778 | 197562 | 0 | None | None | None | Rat | 5.2 | pKd | = | 5.2 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@@H](C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| 44373714 | 197048 | 0 | None | -1 | 2 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1148 | 32 | 14 | 16 | -3.1 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc(=O)oc2cc(OC)ccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)O | 10.1016/s0960-894x(99)00041-4 | |||
| CHEMBL264208 | 197048 | 0 | None | -1 | 2 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1148 | 32 | 14 | 16 | -3.1 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)c1cc(=O)oc2cc(OC)ccc12)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)O | 10.1016/s0960-894x(99)00041-4 | |||
| 44321189 | 198523 | 0 | None | None | None | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1017 | 20 | 14 | 14 | -4.6 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CCSSC[C@H](C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00028a008 | |||
| CHEMBL274397 | 198523 | 0 | None | None | None | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1017 | 20 | 14 | 14 | -4.6 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CCSSC[C@H](C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00028a008 | |||
| 118718749 | 234351 | 0 | None | -1 | 3 | Rat | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1136 | 18 | 11 | 14 | -0.5 | CCN1C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| 118718752 | 234351 | 0 | None | -1 | 3 | Rat | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1136 | 18 | 11 | 14 | -0.5 | CCN1C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| CHEMBL3350119 | 234351 | 0 | None | -1 | 3 | Rat | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1136 | 18 | 11 | 14 | -0.5 | CCN1C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| CHEMBL3350124 | 234351 | 0 | None | -1 | 3 | Rat | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1136 | 18 | 11 | 14 | -0.5 | CCN1C(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| 2042 | 8014 | 41 | None | 40 | 4 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/s0960-894x(99)00041-4 | |||
| 2176 | 8014 | 41 | None | 40 | 4 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/s0960-894x(99)00041-4 | |||
| 439302 | 8014 | 41 | None | 40 | 4 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/s0960-894x(99)00041-4 | |||
| CHEMBL395429 | 8014 | 41 | None | 40 | 4 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/s0960-894x(99)00041-4 | |||
| 2042 | 8014 | 41 | None | 40 | 4 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm00028a008 | |||
| 2176 | 8014 | 41 | None | 40 | 4 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm00028a008 | |||
| 439302 | 8014 | 41 | None | 40 | 4 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm00028a008 | |||
| CHEMBL395429 | 8014 | 41 | None | 40 | 4 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm00028a008 | |||
| 90678222 | 220926 | 0 | None | None | None | Rat | 5.2 | pKd | = | 5.2 | Binding | ChEMBL | 1019 | 17 | 11 | 14 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSSCC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00224a010 | |||
| CHEMBL3273609 | 220926 | 0 | None | None | None | Rat | 5.2 | pKd | = | 5.2 | Binding | ChEMBL | 1019 | 17 | 11 | 14 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSSCC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00224a010 | |||
| 44321206 | 197129 | 0 | None | 13 | 2 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1094 | 20 | 12 | 14 | -2.9 | CN(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C(=O)[C@@H]1CSSC2(CCCCC2)CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm00028a008 | |||
| CHEMBL265017 | 197129 | 0 | None | 13 | 2 | Human | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1094 | 20 | 12 | 14 | -2.9 | CN(CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C(=O)[C@@H]1CSSC2(CCCCC2)CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm00028a008 | |||
| 118718750 | 234352 | 0 | None | -3 | 3 | Rat | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 1151 | 19 | 12 | 15 | -2.3 | CN1C(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| 118718751 | 234352 | 0 | None | -3 | 3 | Rat | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 1151 | 19 | 12 | 15 | -2.3 | CN1C(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| CHEMBL3350120 | 234352 | 0 | None | -3 | 3 | Rat | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 1151 | 19 | 12 | 15 | -2.3 | CN1C(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| CHEMBL3350123 | 234352 | 0 | None | -3 | 3 | Rat | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 1151 | 19 | 12 | 15 | -2.3 | CN1C(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]1Cc1ccc(O)cc1 | 10.1021/jm00010a020 | |||
| 90669120 | 219288 | 1 | None | None | None | Rat | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 1059 | 17 | 11 | 14 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00191a019 | |||
| CHEMBL3229636 | 219288 | 1 | None | None | None | Rat | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 1059 | 17 | 11 | 14 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00191a019 | |||
| CHEMBL3245755 | 486668 | 0 | None | None | None | Rat | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 984 | 17 | 11 | 14 | -2.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00187a002 | |||
| 90669116 | 219284 | 0 | None | -2 | 2 | Rat | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 1019 | 17 | 11 | 14 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00200a007 | |||
| CHEMBL3229632 | 219284 | 0 | None | -2 | 2 | Rat | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 1019 | 17 | 11 | 14 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00200a007 | |||
| 90669116 | 219284 | 0 | None | -2 | 2 | Rat | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 1019 | 17 | 11 | 14 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00191a019 | |||
| CHEMBL3229632 | 219284 | 0 | None | -2 | 2 | Rat | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 1019 | 17 | 11 | 14 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(C)(C)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00191a019 | |||
| 44324578 | 196924 | 0 | None | None | None | Rat | 5.1 | pKd | = | 5.1 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| 44324596 | 196924 | 0 | None | None | None | Rat | 5.1 | pKd | = | 5.1 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| 44324601 | 196924 | 0 | None | None | None | Rat | 5.1 | pKd | = | 5.1 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| 44324625 | 196924 | 0 | None | None | None | Rat | 5.1 | pKd | = | 5.1 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL263153 | 196924 | 0 | None | None | None | Rat | 5.1 | pKd | = | 5.1 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL268779 | 196924 | 0 | None | None | None | Rat | 5.1 | pKd | = | 5.1 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL386547 | 196924 | 0 | None | None | None | Rat | 5.1 | pKd | = | 5.1 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| CHEMBL439482 | 196924 | 0 | None | None | None | Rat | 5.1 | pKd | = | 5.1 | Binding | ChEMBL | 1129 | 31 | 15 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CC1(S)CCCCC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(N)=O | 10.1021/jm00014a022 | |||
| 44373744 | 104407 | 0 | None | 52 | 2 | Human | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 993 | 20 | 12 | 14 | -4.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSSC[C@@H](C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC1=O | 10.1016/s0960-894x(99)00041-4 | |||
| CHEMBL157988 | 104407 | 0 | None | 52 | 2 | Human | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 993 | 20 | 12 | 14 | -4.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSSC[C@@H](C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC1=O | 10.1016/s0960-894x(99)00041-4 | |||
| 44321133 | 317350 | 0 | None | 38 | 2 | Human | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 1060 | 20 | 12 | 14 | -3.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00028a008 | |||
| CHEMBL414582 | 317350 | 0 | None | 38 | 2 | Human | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 1060 | 20 | 12 | 14 | -3.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00028a008 | |||
| 44320760 | 473352 | 0 | None | 52 | 2 | Human | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 992 | 20 | 12 | 14 | -4.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSSC[C@H](C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00028a008 | |||
| CHEMBL87636 | 473352 | 0 | None | 52 | 2 | Human | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 992 | 20 | 12 | 14 | -4.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CCSSC[C@H](C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00028a008 | |||
| 90672304 | 219968 | 0 | None | None | None | Rat | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 1203 | 19 | 11 | 14 | 0.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cc(Br)c(O)c(Br)c2)NC(=O)CC(CC)(CC)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00187a002 | |||
| CHEMBL3245753 | 219968 | 0 | None | None | None | Rat | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 1203 | 19 | 11 | 14 | 0.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cc(Br)c(O)c(Br)c2)NC(=O)CC(CC)(CC)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00187a002 | |||
| CHEMBL2371240 | 477685 | 0 | None | None | None | Human | 5.1 | pKd | = | 5.1 | Binding | ChEMBL | 1043 | 18 | 12 | 14 | -3.9 | CC[C@H](C)[C@@H]1NC(=O)[C@@H]2c3[nH]c4ccccc4c3CCN2C(=O)CCSSC[C@H](C(=O)N(C)CC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/s0960-894x(99)00041-4 | |||
| 90672303 | 219967 | 0 | None | None | None | Rat | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 1147 | 17 | 11 | 14 | -1.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cc(Br)c(O)c(Br)c2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00187a002 | |||
| CHEMBL3245752 | 219967 | 0 | None | None | None | Rat | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 1147 | 17 | 11 | 14 | -1.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2cc(Br)c(O)c(Br)c2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00187a002 | |||
| 118718383 | 234320 | 0 | None | 66 | 3 | Rat | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 1000 | 14 | 11 | 13 | 0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| 118718385 | 234320 | 0 | None | 66 | 3 | Rat | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 1000 | 14 | 11 | 13 | 0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3349464 | 234320 | 0 | None | 66 | 3 | Rat | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 1000 | 14 | 11 | 13 | 0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| CHEMBL3349466 | 234320 | 0 | None | 66 | 3 | Rat | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 1000 | 14 | 11 | 13 | 0.2 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2cc3ccccc3[nH]2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC1=O | 10.1021/jm00010a020 | |||
| 90672302 | 219966 | 0 | None | None | None | Human | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 1033 | 18 | 10 | 13 | 0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(CC)(CC)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC1=O | 10.1021/jm00187a002 | |||
| CHEMBL3245751 | 219966 | 0 | None | None | None | Human | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 1033 | 18 | 10 | 13 | 0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(CC)(CC)SSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC1=O | 10.1021/jm00187a002 | |||
| CHEMBL3273606 | 486700 | 0 | None | None | None | Rat | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 1034 | 17 | 12 | 15 | -2.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CCSSCC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm00224a010 | |||
| 56950588 | 157009 | 0 | None | None | None | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 518 | 7 | 1 | 5 | 2.8 | CCC(CC)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1ccc(C)nc1 | 10.1021/jm201287w | |||
| CHEMBL2037514 | 157009 | 0 | None | None | None | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 518 | 7 | 1 | 5 | 2.8 | CCC(CC)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1ccc(C)nc1 | 10.1021/jm201287w | |||
| 11554957 | 157011 | 0 | None | None | None | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 490 | 7 | 1 | 4 | 3.4 | CCC(CC)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(C)nc1C | 10.1021/jm201287w | |||
| CHEMBL2037516 | 157011 | 0 | None | None | None | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 490 | 7 | 1 | 4 | 3.4 | CCC(CC)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(C)nc1C | 10.1021/jm201287w | |||
| 11570070 | 157012 | 0 | None | None | None | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 532 | 7 | 1 | 5 | 3.1 | CCC(CC)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1ccc(C)nc1C | 10.1021/jm201287w | |||
| CHEMBL2037517 | 157012 | 0 | None | None | None | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 532 | 7 | 1 | 5 | 3.1 | CCC(CC)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1ccc(C)nc1C | 10.1021/jm201287w | |||
| 11605341 | 157002 | 0 | None | None | None | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 476 | 6 | 1 | 4 | 3.0 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1cnc(C)cc1C | 10.1021/jm201287w | |||
| CHEMBL2037507 | 157002 | 0 | None | None | None | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 476 | 6 | 1 | 4 | 3.0 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1cnc(C)cc1C | 10.1021/jm201287w | |||
| 57722466 | 157003 | 0 | None | None | None | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 518 | 6 | 1 | 5 | 2.8 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1cnc(C)cc1C | 10.1021/jm201287w | |||
| CHEMBL2037508 | 157003 | 0 | None | None | None | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 518 | 6 | 1 | 5 | 2.8 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1cnc(C)cc1C | 10.1021/jm201287w | |||
| 11547430 | 157008 | 0 | None | None | None | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 3.1 | CCC(CC)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(C)nc1 | 10.1021/jm201287w | |||
| CHEMBL2037513 | 157008 | 0 | None | None | None | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 3.1 | CCC(CC)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(C)nc1 | 10.1021/jm201287w | |||
| 11691437 | 157010 | 0 | None | None | None | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 3.0 | CCC(CC)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC)c1ccc(C)nc1C | 10.1021/jm201287w | |||
| CHEMBL2037515 | 157010 | 0 | None | None | None | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 3.0 | CCC(CC)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC)c1ccc(C)nc1C | 10.1021/jm201287w | |||
| 56950040 | 156991 | 0 | None | None | None | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 476 | 5 | 1 | 4 | 3.1 | Cc1ccc([C@H](C(=O)N(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)(C)C)cn1 | 10.1021/jm201287w | |||
| CHEMBL2037496 | 156991 | 0 | None | None | None | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 476 | 5 | 1 | 4 | 3.1 | Cc1ccc([C@H](C(=O)N(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)(C)C)cn1 | 10.1021/jm201287w | |||
| 11669836 | 157001 | 0 | None | None | None | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 462 | 6 | 2 | 4 | 2.6 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC)c1cnc(C)cc1C | 10.1021/jm201287w | |||
| CHEMBL2037506 | 157001 | 0 | None | None | None | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 462 | 6 | 2 | 4 | 2.6 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC)c1cnc(C)cc1C | 10.1021/jm201287w | |||
| 56950041 | 156992 | 0 | None | None | None | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 518 | 5 | 1 | 5 | 2.8 | Cc1ccc([C@H](C(=O)N2CCOCC2)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)(C)C)cn1 | 10.1021/jm201287w | |||
| CHEMBL2037497 | 156992 | 0 | None | None | None | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 518 | 5 | 1 | 5 | 2.8 | Cc1ccc([C@H](C(=O)N2CCOCC2)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)(C)C)cn1 | 10.1021/jm201287w | |||
| 11719871 | 157005 | 0 | None | None | None | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 476 | 6 | 1 | 4 | 3.0 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(C)nc1C | 10.1021/jm201287w | |||
| CHEMBL2037510 | 157005 | 0 | None | None | None | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 476 | 6 | 1 | 4 | 3.0 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(C)nc1C | 10.1021/jm201287w | |||
| 11465834 | 275790 | 0 | None | 23 | 4 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 483 | 6 | 1 | 3 | 3.3 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(F)cc1F | 10.1021/jm201287w | |||
| CHEMBL377414 | 275790 | 0 | None | 23 | 4 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 483 | 6 | 1 | 3 | 3.3 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(F)cc1F | 10.1021/jm201287w | |||
| 56675150 | 125937 | 0 | None | 85 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 1382 | 21 | 14 | 19 | -1.2 | CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)C(O)CSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCNC(=O)c2ccc(C3=C4C=CC(N(C)C)=CC4OC4=CC(=[N+](C)C)C=CC43)c(C(=O)O)c2)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC1=O | 10.1021/jm010526+ | |||
| CHEMBL1790723 | 125937 | 0 | None | 85 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 1382 | 21 | 14 | 19 | -1.2 | CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)C(O)CSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCNC(=O)c2ccc(C3=C4C=CC(N(C)C)=CC4OC4=CC(=[N+](C)C)C=CC43)c(C(=O)O)c2)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC1=O | 10.1021/jm010526+ | |||
| 11421025 | 311103 | 0 | None | None | None | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 519 | 7 | 2 | 4 | 4.0 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(C(F)(F)F)o1 | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL401960 | 311103 | 0 | None | None | None | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 519 | 7 | 2 | 4 | 4.0 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(C(F)(F)F)o1 | 10.1016/j.bmcl.2007.11.008 | |||
| 11576272 | 157007 | 0 | None | None | None | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 462 | 7 | 2 | 4 | 2.7 | CCC(CC)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC)c1ccc(C)nc1 | 10.1021/jm201287w | |||
| CHEMBL2037512 | 157007 | 0 | None | None | None | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 462 | 7 | 2 | 4 | 2.7 | CCC(CC)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC)c1ccc(C)nc1 | 10.1021/jm201287w | |||
| 11598736 | 159647 | 0 | None | None | None | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 513 | 8 | 2 | 4 | 2.6 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)CCO)c1ccc(F)cc1F | 10.1021/jm060073e | |||
| CHEMBL210029 | 159647 | 0 | None | None | None | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 513 | 8 | 2 | 4 | 2.6 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)CCO)c1ccc(F)cc1F | 10.1021/jm060073e | |||
| 11634973 | 157006 | 17 | None | 31622 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 518 | 6 | 1 | 5 | 2.8 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1ccc(C)nc1C | 10.1021/jm201287w | |||
| CHEMBL2037511 | 157006 | 17 | None | 31622 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 518 | 6 | 1 | 5 | 2.8 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1ccc(C)nc1C | 10.1021/jm201287w | |||
| DB11934 | 157006 | 17 | None | 31622 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 518 | 6 | 1 | 5 | 2.8 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1ccc(C)nc1C | 10.1021/jm201287w | |||
| 44456151 | 196002 | 0 | None | None | None | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 520 | 7 | 2 | 5 | 3.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1coc(C(F)(F)F)n1 | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL257916 | 196002 | 0 | None | None | None | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 520 | 7 | 2 | 5 | 3.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1coc(C(F)(F)F)n1 | 10.1016/j.bmcl.2007.11.008 | |||
| 56950167 | 156996 | 0 | None | None | None | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 504 | 6 | 1 | 5 | 2.4 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1ccc(C)nc1 | 10.1021/jm201287w | |||
| CHEMBL2037501 | 156996 | 0 | None | None | None | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 504 | 6 | 1 | 5 | 2.4 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1ccc(C)nc1 | 10.1021/jm201287w | |||
| 56657868 | 125932 | 0 | None | 69 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 1297 | 16 | 15 | 21 | -0.8 | CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)C(O)CSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](C(C)O)NC1=O | 10.1021/jm010526+ | |||
| CHEMBL1790719 | 125932 | 0 | None | 69 | 3 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 1297 | 16 | 15 | 21 | -0.8 | CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)C(O)CSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](C(C)O)NC1=O | 10.1021/jm010526+ | |||
| 56671720 | 125934 | 0 | None | 67 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 1324 | 18 | 15 | 21 | -0.9 | CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)C(O)CSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC1=O | 10.1021/jm010526+ | |||
| CHEMBL1790720 | 125934 | 0 | None | 67 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 1324 | 18 | 15 | 21 | -0.9 | CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)C(O)CSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC1=O | 10.1021/jm010526+ | |||
| 56950311 | 156994 | 0 | None | None | None | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 2.7 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(C)nc1 | 10.1021/jm201287w | |||
| CHEMBL2037499 | 156994 | 0 | None | None | None | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 2.7 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(C)nc1 | 10.1021/jm201287w | |||
| 56678446 | 125925 | 0 | None | 18 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 1125 | 16 | 13 | 16 | -0.3 | CC[C@@H](C)[C@H]1NC(=O)[C@@](C)(c2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCN)C(=O)N[C@H](C(N)=O)c2ccc(O)cc2)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]([C@@H](C)O)NC1=O | 10.1021/jm010526+ | |||
| CHEMBL1790712 | 125925 | 0 | None | 18 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 1125 | 16 | 13 | 16 | -0.3 | CC[C@@H](C)[C@H]1NC(=O)[C@@](C)(c2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCN)C(=O)N[C@H](C(N)=O)c2ccc(O)cc2)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]([C@@H](C)O)NC1=O | 10.1021/jm010526+ | |||
| 118734326 | 237393 | 0 | None | None | None | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 1203 | 19 | 13 | 17 | -1.3 | COc1ccc(C[C@@H]2NC(=O)C(N)C3(CCCCC3)SSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 | 10.1021/jm501395b | |||
| CHEMBL3416758 | 237393 | 0 | None | None | None | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 1203 | 19 | 13 | 17 | -1.3 | COc1ccc(C[C@@H]2NC(=O)C(N)C3(CCCCC3)SSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 | 10.1021/jm501395b | |||
| 56664849 | 125935 | 0 | None | 426 | 3 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 1308 | 18 | 14 | 20 | 0.2 | CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC1=O | 10.1021/jm010526+ | |||
| CHEMBL1790721 | 125935 | 0 | None | 426 | 3 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 1308 | 18 | 14 | 20 | 0.2 | CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC1=O | 10.1021/jm010526+ | |||
| 56949758 | 156982 | 0 | None | None | None | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 520 | 7 | 1 | 6 | 2.1 | COc1ccc([C@H](C(=O)N2CCOCC2)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cn1 | 10.1021/jm201287w | |||
| CHEMBL2037487 | 156982 | 0 | None | None | None | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 520 | 7 | 1 | 6 | 2.1 | COc1ccc([C@H](C(=O)N2CCOCC2)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cn1 | 10.1021/jm201287w | |||
| 56949760 | 156984 | 0 | None | None | None | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 491 | 7 | 1 | 5 | 2.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(N(C)C)nc1 | 10.1021/jm201287w | |||
| CHEMBL2037489 | 156984 | 0 | None | None | None | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 491 | 7 | 1 | 5 | 2.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(N(C)C)nc1 | 10.1021/jm201287w | |||
| 56664848 | 125931 | 0 | None | 199 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 1322 | 19 | 14 | 20 | 0.5 | CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC1=O | 10.1021/jm010526+ | |||
| CHEMBL1790718 | 125931 | 0 | None | 199 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 1322 | 19 | 14 | 20 | 0.5 | CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC1=O | 10.1021/jm010526+ | |||
| 53316559 | 119138 | 0 | None | None | None | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 1026 | 17 | 12 | 14 | -3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)C[Se]SC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| CHEMBL1630522 | 119138 | 0 | None | None | None | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 1026 | 17 | 12 | 14 | -3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)C[Se]SC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| 90663156 | 216271 | 0 | None | None | None | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 1377 | 36 | 13 | 17 | 0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)CC1(SCCC(N)=O)CCCCC1)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc1ccc(N=[N+]=[N-])c(I)c1)C(N)=O)[C@@H](C)O | 10.1021/jm010125u | |||
| CHEMBL3142790 | 216271 | 0 | None | None | None | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 1377 | 36 | 13 | 17 | 0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)CC1(SCCC(N)=O)CCCCC1)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc1ccc(N=[N+]=[N-])c(I)c1)C(N)=O)[C@@H](C)O | 10.1021/jm010125u | |||
| 56950039 | 156985 | 0 | None | None | None | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 533 | 7 | 1 | 6 | 2.2 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1ccc(N(C)C)nc1 | 10.1021/jm201287w | |||
| CHEMBL2037490 | 156985 | 0 | None | None | None | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 533 | 7 | 1 | 6 | 2.2 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1ccc(N(C)C)nc1 | 10.1021/jm201287w | |||
| 56671723 | 125939 | 0 | None | 53 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 1311 | 17 | 15 | 21 | -0.4 | CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)C(O)CSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](C(C)O)NC1=O | 10.1021/jm010526+ | |||
| CHEMBL1790729 | 125939 | 0 | None | 53 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 1311 | 17 | 15 | 21 | -0.4 | CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)C(O)CSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](C(C)O)NC1=O | 10.1021/jm010526+ | |||
| 449224 | 333602 | 12 | None | None | None | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 991 | 17 | 11 | 14 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | |||
| CHEMBL439044 | 333602 | 12 | None | None | None | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 991 | 17 | 11 | 14 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | |||
| DB13798 | 333602 | 12 | None | None | None | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 991 | 17 | 11 | 14 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | |||
| 56657867 | 125930 | 0 | None | 40 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 1338 | 19 | 15 | 21 | -0.5 | CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)C(O)CSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC1=O | 10.1021/jm010526+ | |||
| CHEMBL1790717 | 125930 | 0 | None | 40 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 1338 | 19 | 15 | 21 | -0.5 | CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)C(O)CSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](CCC(N)=O)NC1=O | 10.1021/jm010526+ | |||
| 44456352 | 313996 | 0 | None | None | None | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 468 | 6 | 1 | 5 | 2.7 | Cc1nc([C@H](C(=O)N(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cs1 | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL408691 | 313996 | 0 | None | None | None | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 468 | 6 | 1 | 5 | 2.7 | Cc1nc([C@H](C(=O)N(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cs1 | 10.1016/j.bmcl.2007.11.008 | |||
| 11662784 | 276618 | 0 | None | None | None | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 469 | 6 | 2 | 3 | 2.9 | CNC(=O)[C@@H](c1ccc(F)cc1F)N1C(=O)[C@@H](C2Cc3ccccc3C2)NC(=O)[C@H]1CC(C)C | 10.1021/jm060073e | |||
| CHEMBL379192 | 276618 | 0 | None | None | None | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 469 | 6 | 2 | 3 | 2.9 | CNC(=O)[C@@H](c1ccc(F)cc1F)N1C(=O)[C@@H](C2Cc3ccccc3C2)NC(=O)[C@H]1CC(C)C | 10.1021/jm060073e | |||
| 56949757 | 156981 | 0 | None | None | None | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 478 | 7 | 1 | 5 | 2.4 | COc1ccc([C@H](C(=O)N(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cn1 | 10.1021/jm201287w | |||
| CHEMBL2037486 | 156981 | 0 | None | None | None | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 478 | 7 | 1 | 5 | 2.4 | COc1ccc([C@H](C(=O)N(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cn1 | 10.1021/jm201287w | |||
| 56949906 | 156987 | 0 | None | None | None | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 504 | 6 | 1 | 5 | 2.4 | Cc1ccc([C@H](C(=O)N2CCOCC2)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cn1 | 10.1021/jm201287w | |||
| CHEMBL2037492 | 156987 | 0 | None | None | None | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 504 | 6 | 1 | 5 | 2.4 | Cc1ccc([C@H](C(=O)N2CCOCC2)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cn1 | 10.1021/jm201287w | |||
| 11705315 | 157004 | 0 | None | None | None | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 462 | 6 | 2 | 4 | 2.6 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC)c1ccc(C)nc1C | 10.1021/jm201287w | |||
| CHEMBL2037509 | 157004 | 0 | None | None | None | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 462 | 6 | 2 | 4 | 2.6 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC)c1ccc(C)nc1C | 10.1021/jm201287w | |||
| 56657866 | 125924 | 0 | None | 75 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 1281 | 16 | 14 | 20 | 0.3 | CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]([C@H](C)O)NC1=O | 10.1021/jm010526+ | |||
| CHEMBL1790711 | 125924 | 0 | None | 75 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 1281 | 16 | 14 | 20 | 0.3 | CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]([C@H](C)O)NC1=O | 10.1021/jm010526+ | |||
| 2042 | 8014 | 41 | None | -1 | 6 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmc.2016.05.062 | |||
| 2176 | 8014 | 41 | None | -1 | 6 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmc.2016.05.062 | |||
| 439302 | 8014 | 41 | None | -1 | 6 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmc.2016.05.062 | |||
| CHEMBL395429 | 8014 | 41 | None | -1 | 6 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmc.2016.05.062 | |||
| 118734326 | 237393 | 0 | None | None | None | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 1203 | 19 | 13 | 17 | -1.3 | COc1ccc(C[C@@H]2NC(=O)C(N)C3(CCCCC3)SSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 | 10.1021/jm501395b | |||
| CHEMBL3416758 | 237393 | 0 | None | None | None | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 1203 | 19 | 13 | 17 | -1.3 | COc1ccc(C[C@@H]2NC(=O)C(N)C3(CCCCC3)SSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 | 10.1021/jm501395b | |||
| 10461270 | 7472 | 18 | None | 2 | 5 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 603 | 9 | 0 | 5 | 6.9 | CCN(C(=O)c1ccc(c(c1)[C@@]1(C)c2cc(Cl)ccc2N(C1=O)Cc1ccc(cc1OC)OC)Cl)Cc1cccnc1 | 10.1021/jm901812z | |||
| 2201 | 7472 | 18 | None | 2 | 5 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 603 | 9 | 0 | 5 | 6.9 | CCN(C(=O)c1ccc(c(c1)[C@@]1(C)c2cc(Cl)ccc2N(C1=O)Cc1ccc(cc1OC)OC)Cl)Cc1cccnc1 | 10.1021/jm901812z | |||
| CHEMBL1615640 | 7472 | 18 | None | 2 | 5 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 603 | 9 | 0 | 5 | 6.9 | CCN(C(=O)c1ccc(c(c1)[C@@]1(C)c2cc(Cl)ccc2N(C1=O)Cc1ccc(cc1OC)OC)Cl)Cc1cccnc1 | 10.1021/jm901812z | |||
| 44279520 | 200209 | 0 | None | None | None | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 626 | 7 | 1 | 10 | 2.9 | O=C(Cn1ccc(N2CCOCC2)nc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL286895 | 200209 | 0 | None | None | None | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 626 | 7 | 1 | 10 | 2.9 | O=C(Cn1ccc(N2CCOCC2)nc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| 11590596 | 333551 | 0 | None | None | None | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 455 | 6 | 2 | 3 | 2.6 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(N)=O)c1ccc(F)cc1F | 10.1021/jm060073e | |||
| CHEMBL438609 | 333551 | 0 | None | None | None | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 455 | 6 | 2 | 3 | 2.6 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(N)=O)c1ccc(F)cc1F | 10.1021/jm060073e | |||
| 56949907 | 156988 | 0 | None | None | None | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 488 | 6 | 1 | 4 | 3.2 | Cc1ccc([C@H](C(=O)N2CCCC2)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cn1 | 10.1021/jm201287w | |||
| CHEMBL2037493 | 156988 | 0 | None | None | None | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 488 | 6 | 1 | 4 | 3.2 | Cc1ccc([C@H](C(=O)N2CCCC2)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cn1 | 10.1021/jm201287w | |||
| 56950043 | 156995 | 0 | None | None | None | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 504 | 6 | 1 | 5 | 2.4 | CC[C@@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1ccc(C)nc1 | 10.1021/jm201287w | |||
| CHEMBL2037500 | 156995 | 0 | None | None | None | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 504 | 6 | 1 | 5 | 2.4 | CC[C@@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1ccc(C)nc1 | 10.1021/jm201287w | |||
| 155536940 | 336772 | 0 | None | None | None | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 1074 | 20 | 12 | 15 | -2.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | |||
| CHEMBL4474284 | 336772 | 0 | None | None | None | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 1074 | 20 | 12 | 15 | -2.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | |||
| 2042 | 8014 | 41 | None | -1 | 6 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.8b01691 | |||
| 2176 | 8014 | 41 | None | -1 | 6 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.8b01691 | |||
| 439302 | 8014 | 41 | None | -1 | 6 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.8b01691 | |||
| CHEMBL395429 | 8014 | 41 | None | -1 | 6 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/acs.jmedchem.8b01691 | |||
| 18700180 | 195209 | 0 | None | 1 | 2 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 533 | 6 | 0 | 6 | 4.2 | O=C(Cc1ccc(N2CCOCC2)cc1OCC(F)(F)F)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL25353 | 195209 | 0 | None | 1 | 2 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 533 | 6 | 0 | 6 | 4.2 | O=C(Cc1ccc(N2CCOCC2)cc1OCC(F)(F)F)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| 90663155 | 216270 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1363 | 35 | 14 | 17 | 0.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CC1(SCCC(N)=O)CCCCC1)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc1ccc(N=[N+]=[N-])c(I)c1)C(N)=O)[C@@H](C)O | 10.1021/jm010125u | |||
| CHEMBL3142789 | 216270 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1363 | 35 | 14 | 17 | 0.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CC1(SCCC(N)=O)CCCCC1)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc1ccc(N=[N+]=[N-])c(I)c1)C(N)=O)[C@@H](C)O | 10.1021/jm010125u | |||
| 11340891 | 6755 | 33 | None | 891 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 10.1021/jm901812z | |||
| 8403 | 6755 | 33 | None | 891 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 10.1021/jm901812z | |||
| CHEMBL429736 | 6755 | 33 | None | 891 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 10.1021/jm901812z | |||
| DB11818 | 6755 | 33 | None | 891 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 10.1021/jm901812z | |||
| 11590614 | 161183 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 456 | 6 | 2 | 3 | 3.2 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)O)c1ccc(F)cc1F | 10.1021/jm060073e | |||
| CHEMBL211556 | 161183 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 456 | 6 | 2 | 3 | 3.2 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)O)c1ccc(F)cc1F | 10.1021/jm060073e | |||
| 11295207 | 275772 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 511 | 6 | 2 | 4 | 2.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CC(O)C1)c1ccc(F)cc1F | 10.1021/jm060073e | |||
| CHEMBL377315 | 275772 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 511 | 6 | 2 | 4 | 2.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CC(O)C1)c1ccc(F)cc1F | 10.1021/jm060073e | |||
| 11465834 | 275790 | 0 | None | 23 | 4 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 483 | 6 | 1 | 3 | 3.3 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(F)cc1F | 10.1021/jm060073e | |||
| CHEMBL377414 | 275790 | 0 | None | 23 | 4 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 483 | 6 | 1 | 3 | 3.3 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(F)cc1F | 10.1021/jm060073e | |||
| 11569527 | 276489 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 495 | 6 | 1 | 3 | 3.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCC1)c1ccc(F)cc1F | 10.1021/jm060073e | |||
| CHEMBL378718 | 276489 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 495 | 6 | 1 | 3 | 3.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCC1)c1ccc(F)cc1F | 10.1021/jm060073e | |||
| 11340891 | 6755 | 33 | None | 891 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 10.1016/j.bmcl.2007.11.008 | |||
| 8403 | 6755 | 33 | None | 891 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL429736 | 6755 | 33 | None | 891 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 10.1016/j.bmcl.2007.11.008 | |||
| DB11818 | 6755 | 33 | None | 891 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 10.1016/j.bmcl.2007.11.008 | |||
| 135413562 | 4496 | 12 | None | 1 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 624 | 14 | 3 | 7 | 1.1 | CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C | 10.1021/jm050645f | |||
| 2194 | 4496 | 12 | None | 1 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 624 | 14 | 3 | 7 | 1.1 | CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C | 10.1021/jm050645f | |||
| CHEMBL445816 | 4496 | 12 | None | 1 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 624 | 14 | 3 | 7 | 1.1 | CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C | 10.1021/jm050645f | |||
| 135413562 | 4496 | 12 | None | 1 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 624 | 14 | 3 | 7 | 1.1 | CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C | 10.1021/jm901812z | |||
| 2194 | 4496 | 12 | None | 1 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 624 | 14 | 3 | 7 | 1.1 | CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C | 10.1021/jm901812z | |||
| CHEMBL445816 | 4496 | 12 | None | 1 | 5 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 624 | 14 | 3 | 7 | 1.1 | CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C | 10.1021/jm901812z | |||
| 44297449 | 333859 | 0 | None | -1 | 3 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1315 | 37 | 15 | 16 | -2.2 | CN(C(=O)Cc1cccc(N=[N+]=[N-])c1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | 10.1021/jm00038a013 | |||
| CHEMBL441195 | 333859 | 0 | None | -1 | 3 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1315 | 37 | 15 | 16 | -2.2 | CN(C(=O)Cc1cccc(N=[N+]=[N-])c1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | 10.1021/jm00038a013 | |||
| 118734326 | 237393 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1203 | 19 | 13 | 17 | -1.3 | COc1ccc(C[C@@H]2NC(=O)C(N)C3(CCCCC3)SSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 | 10.1021/jm501395b | |||
| CHEMBL3416758 | 237393 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1203 | 19 | 13 | 17 | -1.3 | COc1ccc(C[C@@H]2NC(=O)C(N)C3(CCCCC3)SSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 | 10.1021/jm501395b | |||
| 135413562 | 4496 | 12 | None | -1 | 5 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 624 | 14 | 3 | 7 | 1.1 | CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C | 10.1021/jm050645f | |||
| 2194 | 4496 | 12 | None | -1 | 5 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 624 | 14 | 3 | 7 | 1.1 | CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C | 10.1021/jm050645f | |||
| CHEMBL445816 | 4496 | 12 | None | -1 | 5 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 624 | 14 | 3 | 7 | 1.1 | CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C | 10.1021/jm050645f | |||
| 135413562 | 4496 | 12 | None | -1 | 5 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 624 | 14 | 3 | 7 | 1.1 | CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C | 10.1021/jm901812z | |||
| 2194 | 4496 | 12 | None | -1 | 5 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 624 | 14 | 3 | 7 | 1.1 | CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C | 10.1021/jm901812z | |||
| CHEMBL445816 | 4496 | 12 | None | -1 | 5 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 624 | 14 | 3 | 7 | 1.1 | CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C | 10.1021/jm901812z | |||
| 1103817 | 40884 | 7 | None | 3 | 4 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 492 | 8 | 2 | 6 | 3.1 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(C)cc2)cc1 | 10.1021/jm901812z | |||
| CHEMBL1254117 | 40884 | 7 | None | 3 | 4 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 492 | 8 | 2 | 6 | 3.1 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(C)cc2)cc1 | 10.1021/jm901812z | |||
| CHEMBL2112249 | 485097 | 2 | None | 8 | 2 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 766 | 6 | 4 | 7 | 2.6 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 9938406 | 184110 | 1 | None | 1 | 6 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 589 | 7 | 0 | 6 | 4.7 | CC(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)c(OCC(F)(F)F)c2)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL24526 | 184110 | 1 | None | 1 | 6 | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 589 | 7 | 0 | 6 | 4.7 | CC(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)c(OCC(F)(F)F)c2)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| 53317550 | 119139 | 0 | None | None | None | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1026 | 17 | 12 | 14 | -3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CS[Se]C[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| CHEMBL1630523 | 119139 | 0 | None | None | None | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1026 | 17 | 12 | 14 | -3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CS[Se]C[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| 2042 | 8014 | 41 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | |||
| 2176 | 8014 | 41 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | |||
| 439302 | 8014 | 41 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | |||
| CHEMBL395429 | 8014 | 41 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | |||
| 2042 | 8014 | 41 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | |||
| 2176 | 8014 | 41 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | |||
| 439302 | 8014 | 41 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | |||
| CHEMBL395429 | 8014 | 41 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | |||
| 2042 | 8014 | 41 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm100989w | |||
| 2176 | 8014 | 41 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm100989w | |||
| 439302 | 8014 | 41 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm100989w | |||
| CHEMBL395429 | 8014 | 41 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm100989w | |||
| 44456194 | 195726 | 0 | None | None | None | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 478 | 7 | 1 | 5 | 2.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1coc(C2CC2)n1 | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL256692 | 195726 | 0 | None | None | None | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 478 | 7 | 1 | 5 | 2.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1coc(C2CC2)n1 | 10.1016/j.bmcl.2007.11.008 | |||
| 44455964 | 197859 | 0 | None | None | None | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 529 | 7 | 2 | 4 | 3.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(Br)o1 | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL270624 | 197859 | 0 | None | None | None | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 529 | 7 | 2 | 4 | 3.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(Br)o1 | 10.1016/j.bmcl.2007.11.008 | |||
| 25212177 | 348862 | 6 | None | 7 | 4 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 463 | 7 | 0 | 7 | 3.9 | COc1ccc(N(Cc2ccc(-c3ccccc3C)cn2)S(=O)(=O)c2cn(C)c(C)n2)cn1 | 10.1016/j.bmcl.2008.11.018 | |||
| CHEMBL456263 | 348862 | 6 | None | 7 | 4 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 463 | 7 | 0 | 7 | 3.9 | COc1ccc(N(Cc2ccc(-c3ccccc3C)cn2)S(=O)(=O)c2cn(C)c(C)n2)cn1 | 10.1016/j.bmcl.2008.11.018 | |||
| 56950170 | 156999 | 0 | None | None | None | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 476 | 6 | 1 | 4 | 3.0 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1cc(C)cnc1C | 10.1021/jm201287w | |||
| CHEMBL2037504 | 156999 | 0 | None | None | None | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 476 | 6 | 1 | 4 | 3.0 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1cc(C)cnc1C | 10.1021/jm201287w | |||
| 56950171 | 157000 | 0 | None | None | None | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 518 | 6 | 1 | 5 | 2.8 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1cc(C)cnc1C | 10.1021/jm201287w | |||
| CHEMBL2037505 | 157000 | 0 | None | None | None | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 518 | 6 | 1 | 5 | 2.8 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1cc(C)cnc1C | 10.1021/jm201287w | |||
| 2042 | 8014 | 41 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm010526+ | |||
| 2176 | 8014 | 41 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm010526+ | |||
| 439302 | 8014 | 41 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm010526+ | |||
| CHEMBL395429 | 8014 | 41 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm010526+ | |||
| 2042 | 8014 | 41 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.ejmech.2015.11.050 | |||
| 2176 | 8014 | 41 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.ejmech.2015.11.050 | |||
| 439302 | 8014 | 41 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.ejmech.2015.11.050 | |||
| CHEMBL395429 | 8014 | 41 | None | -1 | 6 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.ejmech.2015.11.050 | |||
| 10627984 | 468607 | 0 | None | 4 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 646 | 8 | 0 | 7 | 5.5 | CCc1c(CN2CCC(Oc3cc(OC)c(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)cc3F)CC2)c(C)cc(C)[n+]1[O-] | 10.1021/jm9800797 | |||
| CHEMBL66985 | 468607 | 0 | None | 4 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 646 | 8 | 0 | 7 | 5.5 | CCc1c(CN2CCC(Oc3cc(OC)c(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)cc3F)CC2)c(C)cc(C)[n+]1[O-] | 10.1021/jm9800797 | |||
| 10723001 | 202424 | 0 | None | 3 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 658 | 7 | 0 | 7 | 5.3 | COc1cc(OC2CCN(Cc3ccc[n+]([O-])c3C(F)(F)F)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL303700 | 202424 | 0 | None | 3 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 658 | 7 | 0 | 7 | 5.3 | COc1cc(OC2CCN(Cc3ccc[n+]([O-])c3C(F)(F)F)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 18700180 | 195209 | 0 | None | -1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 533 | 6 | 0 | 6 | 4.2 | O=C(Cc1ccc(N2CCOCC2)cc1OCC(F)(F)F)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL25353 | 195209 | 0 | None | -1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 533 | 6 | 0 | 6 | 4.2 | O=C(Cc1ccc(N2CCOCC2)cc1OCC(F)(F)F)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| 2042 | 8014 | 41 | None | 1 | 6 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm00171a003 | |||
| 2176 | 8014 | 41 | None | 1 | 6 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm00171a003 | |||
| 439302 | 8014 | 41 | None | 1 | 6 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm00171a003 | |||
| CHEMBL395429 | 8014 | 41 | None | 1 | 6 | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm00171a003 | |||
| 135476004 | 160551 | 0 | None | 8 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 597 | 10 | 2 | 8 | 2.7 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(OCCN2CCOCC2)cc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1039/C5MD00566C | |||
| CHEMBL2113185 | 160551 | 0 | None | 8 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 597 | 10 | 2 | 8 | 2.7 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(OCCN2CCOCC2)cc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1039/C5MD00566C | |||
| 3126 | 484342 | 1 | None | None | None | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 991 | 17 | 11 | 14 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm9607156 | |||
| CHEMBL435716 | 484342 | 1 | None | None | None | Rat | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 991 | 17 | 11 | 14 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm9607156 | |||
| 135491819 | 160550 | 0 | None | 104 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 597 | 12 | 4 | 7 | 2.4 | O=C(CCc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1)NCCCO | 10.1021/jm050645f | |||
| CHEMBL2113181 | 160550 | 0 | None | 104 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 597 | 12 | 4 | 7 | 2.4 | O=C(CCc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1)NCCCO | 10.1021/jm050645f | |||
| 135476004 | 160551 | 0 | None | 8 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 597 | 10 | 2 | 8 | 2.7 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(OCCN2CCOCC2)cc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm050645f | |||
| CHEMBL2113185 | 160551 | 0 | None | 8 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 597 | 10 | 2 | 8 | 2.7 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(OCCN2CCOCC2)cc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm050645f | |||
| 155527198 | 335719 | 0 | None | None | None | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1056 | 20 | 12 | 14 | -2.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | |||
| CHEMBL4458988 | 335719 | 0 | None | None | None | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1056 | 20 | 12 | 14 | -2.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | |||
| CHEMBL3814744 | 487605 | 0 | None | None | None | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1020 | 17 | 11 | 15 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | |||
| 5311065 | 484177 | 30 | None | -2 | 8 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm060928n | |||
| 817 | 484177 | 30 | None | -2 | 8 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm060928n | |||
| CHEMBL1429 | 484177 | 30 | None | -2 | 8 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm060928n | |||
| DB00035 | 484177 | 30 | None | -2 | 8 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm060928n | |||
| 10555563 | 202203 | 0 | None | 4 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 600 | 7 | 0 | 7 | 4.8 | COc1cc(OC2CCN(Cc3c(C)cc[n+]([O-])c3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL302297 | 202203 | 0 | None | 4 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 600 | 7 | 0 | 7 | 4.8 | COc1cc(OC2CCN(Cc3c(C)cc[n+]([O-])c3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 10579886 | 213336 | 0 | None | 4 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 632 | 7 | 0 | 7 | 5.2 | COc1cc(OC2CCN(Cc3c(C)cc(C)[n+]([O-])c3C)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL308673 | 213336 | 0 | None | 4 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 632 | 7 | 0 | 7 | 5.2 | COc1cc(OC2CCN(Cc3c(C)cc(C)[n+]([O-])c3C)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 15840423 | 184002 | 0 | None | 1 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 601 | 9 | 0 | 6 | 5.6 | O=C(Cc1ccc(OC2CCN(CC3CC3)CC2)cc1OCC(F)(F)F)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL24456 | 184002 | 0 | None | 1 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 601 | 9 | 0 | 6 | 5.6 | O=C(Cc1ccc(OC2CCN(CC3CC3)CC2)cc1OCC(F)(F)F)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| 11340891 | 6755 | 33 | None | 891 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 10.1016/j.bmcl.2007.11.008 | |||
| 8403 | 6755 | 33 | None | 891 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL429736 | 6755 | 33 | None | 891 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 10.1016/j.bmcl.2007.11.008 | |||
| DB11818 | 6755 | 33 | None | 891 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 10.1016/j.bmcl.2007.11.008 | |||
| 11511019 | 159607 | 0 | None | None | None | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 465 | 7 | 2 | 4 | 3.3 | Cc1ccc([C@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)o1 | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL209864 | 159607 | 0 | None | None | None | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 465 | 7 | 2 | 4 | 3.3 | Cc1ccc([C@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)o1 | 10.1016/j.bmcl.2007.11.008 | |||
| 44456383 | 195929 | 0 | None | None | None | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 545 | 7 | 2 | 4 | 4.2 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1cc(Br)cs1 | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL257660 | 195929 | 0 | None | None | None | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 545 | 7 | 2 | 4 | 4.2 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1cc(Br)cs1 | 10.1016/j.bmcl.2007.11.008 | |||
| 44279572 | 202816 | 0 | None | None | None | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 617 | 7 | 1 | 8 | 4.7 | O=C(Cn1ccc(-c2ccccc2)nc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL30510 | 202816 | 0 | None | None | None | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 617 | 7 | 1 | 8 | 4.7 | O=C(Cn1ccc(-c2ccccc2)nc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| 11488952 | 159212 | 0 | None | 31 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 501 | 7 | 2 | 4 | 4.2 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc2occc2c1 | 10.1021/jm060073e | |||
| CHEMBL208787 | 159212 | 0 | None | 31 | 3 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 501 | 7 | 2 | 4 | 4.2 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc2occc2c1 | 10.1021/jm060073e | |||
| 56950042 | 156993 | 0 | None | None | None | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 2.7 | CC[C@@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(C)nc1 | 10.1021/jm201287w | |||
| CHEMBL2037498 | 156993 | 0 | None | None | None | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 2.7 | CC[C@@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(C)nc1 | 10.1021/jm201287w | |||
| 56950168 | 156997 | 0 | None | None | None | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 478 | 6 | 1 | 4 | 1.9 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(C)[n+]([O-])c1 | 10.1021/jm201287w | |||
| CHEMBL2037502 | 156997 | 0 | None | None | None | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 478 | 6 | 1 | 4 | 1.9 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(C)[n+]([O-])c1 | 10.1021/jm201287w | |||
| 44428107 | 24608 | 0 | None | -11 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 2058 | 46 | 18 | 25 | 6.0 | CC1CC(C)(C)Nc2c1cc1c(c2S(=O)(=O)O)OC2C(=C1c1c(Cl)c(SCC(=O)NCCCCCC(=O)N(C(=O)[C@H]3CCN(C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@@H](Cc4ccc(O)cc4)N(C)C(=O)CCc4ccc(O)cc4)C3)[C@@H](CCCCN)C(N)=O)c(Cl)c(Cl)c1C(=O)O)CC1C(=NC(C)(C)CC1C)C2S(=O)(=O)O | 10.1021/jm061404q | |||
| 91935616 | 24608 | 0 | None | -11 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 2058 | 46 | 18 | 25 | 6.0 | CC1CC(C)(C)Nc2c1cc1c(c2S(=O)(=O)O)OC2C(=C1c1c(Cl)c(SCC(=O)NCCCCCC(=O)N(C(=O)[C@H]3CCN(C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@@H](Cc4ccc(O)cc4)N(C)C(=O)CCc4ccc(O)cc4)C3)[C@@H](CCCCN)C(N)=O)c(Cl)c(Cl)c1C(=O)O)CC1C(=NC(C)(C)CC1C)C2S(=O)(=O)O | 10.1021/jm061404q | |||
| CHEMBL1161978 | 24608 | 0 | None | -11 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 2058 | 46 | 18 | 25 | 6.0 | CC1CC(C)(C)Nc2c1cc1c(c2S(=O)(=O)O)OC2C(=C1c1c(Cl)c(SCC(=O)NCCCCCC(=O)N(C(=O)[C@H]3CCN(C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@@H](Cc4ccc(O)cc4)N(C)C(=O)CCc4ccc(O)cc4)C3)[C@@H](CCCCN)C(N)=O)c(Cl)c(Cl)c1C(=O)O)CC1C(=NC(C)(C)CC1C)C2S(=O)(=O)O | 10.1021/jm061404q | |||
| CHEMBL3813894 | 487597 | 0 | None | None | None | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1020 | 17 | 11 | 15 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | |||
| 135493119 | 160559 | 0 | None | 4 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 569 | 11 | 2 | 7 | 3.3 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1039/C5MD00566C | |||
| CHEMBL2113201 | 160559 | 0 | None | 4 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 569 | 11 | 2 | 7 | 3.3 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1039/C5MD00566C | |||
| 56665480 | 125919 | 0 | None | 91 | 2 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 754 | 6 | 2 | 8 | 3.5 | CC[C@@H](C)[C@@H]1/N=C(\S)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCC=NN2C(=O)[C@H]2CCC=NN2C1=O | 10.1021/jm00171a003 | |||
| CHEMBL1790544 | 125919 | 0 | None | 91 | 2 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 754 | 6 | 2 | 8 | 3.5 | CC[C@@H](C)[C@@H]1/N=C(\S)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCC=NN2C(=O)[C@H]2CCC=NN2C1=O | 10.1021/jm00171a003 | |||
| 10531717 | 203009 | 0 | None | 4 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 604 | 7 | 0 | 7 | 4.6 | COc1cc(OC2CCN(Cc3ccc[n+]([O-])c3C)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL306416 | 203009 | 0 | None | 4 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 604 | 7 | 0 | 7 | 4.6 | COc1cc(OC2CCN(Cc3ccc[n+]([O-])c3C)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 135493119 | 160559 | 0 | None | 4 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 569 | 11 | 2 | 7 | 3.3 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113201 | 160559 | 0 | None | 4 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 569 | 11 | 2 | 7 | 3.3 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| 76073634 | 234791 | 7 | None | None | None | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1041 | 20 | 11 | 13 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | |||
| CHEMBL3354594 | 234791 | 7 | None | None | None | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1041 | 20 | 11 | 13 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | |||
| DB12932 | 234791 | 7 | None | None | None | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1041 | 20 | 11 | 13 | -1.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)Cc2ccc(F)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | |||
| 44275447 | 196766 | 0 | None | -1 | 4 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1111 | 32 | 13 | 13 | -3.6 | CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(N)=O | 10.1021/jm9804782 | |||
| CHEMBL262035 | 196766 | 0 | None | -1 | 4 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1111 | 32 | 13 | 13 | -3.6 | CN(C(=O)Cc1ccccc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(N)=O | 10.1021/jm9804782 | |||
| 146681949 | 8624 | 35 | None | -4 | 8 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm060928n | |||
| 2168 | 8624 | 35 | None | -4 | 8 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm060928n | |||
| 2810 | 8624 | 35 | None | -4 | 8 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm060928n | |||
| 644077 | 8624 | 35 | None | -4 | 8 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm060928n | |||
| CHEMBL373742 | 8624 | 35 | None | -4 | 8 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm060928n | |||
| DB00067 | 8624 | 35 | None | -4 | 8 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm060928n | |||
| P01185 | 8624 | 35 | None | -4 | 8 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm060928n | |||
| P01186 | 8624 | 35 | None | -4 | 8 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm060928n | |||
| P35455 | 8624 | 35 | None | -4 | 8 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm060928n | |||
| 10556286 | 469253 | 0 | None | 10 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 658 | 7 | 0 | 7 | 5.3 | COc1cc(OC2CCN(Cc3c[n+]([O-])ccc3C(F)(F)F)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL71540 | 469253 | 0 | None | 10 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 658 | 7 | 0 | 7 | 5.3 | COc1cc(OC2CCN(Cc3c[n+]([O-])ccc3C(F)(F)F)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 15840423 | 184002 | 0 | None | -1 | 2 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 601 | 9 | 0 | 6 | 5.6 | O=C(Cc1ccc(OC2CCN(CC3CC3)CC2)cc1OCC(F)(F)F)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL24456 | 184002 | 0 | None | -1 | 2 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 601 | 9 | 0 | 6 | 5.6 | O=C(Cc1ccc(OC2CCN(CC3CC3)CC2)cc1OCC(F)(F)F)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| 2042 | 8014 | 41 | None | -1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmc.2018.03.019 | |||
| 2176 | 8014 | 41 | None | -1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmc.2018.03.019 | |||
| 439302 | 8014 | 41 | None | -1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmc.2018.03.019 | |||
| CHEMBL395429 | 8014 | 41 | None | -1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmc.2018.03.019 | |||
| 44275525 | 387710 | 0 | None | -16 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1525 | 36 | 12 | 20 | 1.8 | CN(C)c1ccc2c(c1)Oc1cc(N(C)C)ccc1C21OC(=O)c2cc(C(=O)N(C(=O)[C@@H]3CCCN3C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccc(O)cc3)N(C)C(=O)CCc3ccc(O)cc3)[C@@H](CCCCN)C(N)=O)ccc21 | 10.1021/jm9804782 | |||
| 91931055 | 387710 | 0 | None | -16 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1525 | 36 | 12 | 20 | 1.8 | CN(C)c1ccc2c(c1)Oc1cc(N(C)C)ccc1C21OC(=O)c2cc(C(=O)N(C(=O)[C@@H]3CCCN3C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccc(O)cc3)N(C)C(=O)CCc3ccc(O)cc3)[C@@H](CCCCN)C(N)=O)ccc21 | 10.1021/jm9804782 | |||
| CHEMBL540192 | 387710 | 0 | None | -16 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1525 | 36 | 12 | 20 | 1.8 | CN(C)c1ccc2c(c1)Oc1cc(N(C)C)ccc1C21OC(=O)c2cc(C(=O)N(C(=O)[C@@H]3CCCN3C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3ccc(O)cc3)N(C)C(=O)CCc3ccc(O)cc3)[C@@H](CCCCN)C(N)=O)ccc21 | 10.1021/jm9804782 | |||
| 2239 | 2222 | 0 | None | 501 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 497 | 7 | 2 | 3 | 3.7 | CC(C[C@@H]1C(=O)N[C@@H](C(=O)N1[C@H](c1ccc(cc1F)F)C(=O)NC(C)C)C1Cc2c(C1)cccc2)C | 10.1016/j.bmcl.2007.11.008 | |||
| 6918854 | 2222 | 0 | None | 501 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 497 | 7 | 2 | 3 | 3.7 | CC(C[C@@H]1C(=O)N[C@@H](C(=O)N1[C@H](c1ccc(cc1F)F)C(=O)NC(C)C)C1Cc2c(C1)cccc2)C | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL196478 | 2222 | 0 | None | 501 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 497 | 7 | 2 | 3 | 3.7 | CC(C[C@@H]1C(=O)N[C@@H](C(=O)N1[C@H](c1ccc(cc1F)F)C(=O)NC(C)C)C1Cc2c(C1)cccc2)C | 10.1016/j.bmcl.2007.11.008 | |||
| 44456109 | 195664 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 482 | 8 | 2 | 6 | 1.6 | Cc1nc([C@H](C(=O)N(C)CCO)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)co1 | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL256391 | 195664 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 482 | 8 | 2 | 6 | 1.6 | Cc1nc([C@H](C(=O)N(C)CCO)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)co1 | 10.1016/j.bmcl.2007.11.008 | |||
| 44456004 | 198058 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 479 | 7 | 2 | 4 | 3.6 | Cc1cc([C@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)oc1C | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL271657 | 198058 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 479 | 7 | 2 | 4 | 3.6 | Cc1cc([C@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)oc1C | 10.1016/j.bmcl.2007.11.008 | |||
| 44456229 | 311095 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 466 | 7 | 2 | 5 | 2.7 | Cc1nc([C@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)co1 | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL401910 | 311095 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 466 | 7 | 2 | 5 | 2.7 | Cc1nc([C@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)co1 | 10.1016/j.bmcl.2007.11.008 | |||
| 44279607 | 200050 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 595 | 6 | 1 | 10 | 3.0 | Cn1ncc2c(=O)n(CC(=O)NCc3cc4cc(C(=O)N5CCC(N6C(=O)OCc7ccccc76)CC5)ccc4o3)cnc21 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL285820 | 200050 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 595 | 6 | 1 | 10 | 3.0 | Cn1ncc2c(=O)n(CC(=O)NCc3cc4cc(C(=O)N5CCC(N6C(=O)OCc7ccccc76)CC5)ccc4o3)cnc21 | 10.1016/s0960-894x(02)00160-9 | |||
| 2239 | 2222 | 0 | None | 501 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 497 | 7 | 2 | 3 | 3.7 | CC(C[C@@H]1C(=O)N[C@@H](C(=O)N1[C@H](c1ccc(cc1F)F)C(=O)NC(C)C)C1Cc2c(C1)cccc2)C | 10.1021/jm901812z | |||
| 6918854 | 2222 | 0 | None | 501 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 497 | 7 | 2 | 3 | 3.7 | CC(C[C@@H]1C(=O)N[C@@H](C(=O)N1[C@H](c1ccc(cc1F)F)C(=O)NC(C)C)C1Cc2c(C1)cccc2)C | 10.1021/jm901812z | |||
| CHEMBL196478 | 2222 | 0 | None | 501 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 497 | 7 | 2 | 3 | 3.7 | CC(C[C@@H]1C(=O)N[C@@H](C(=O)N1[C@H](c1ccc(cc1F)F)C(=O)NC(C)C)C1Cc2c(C1)cccc2)C | 10.1021/jm901812z | |||
| 2239 | 2222 | 0 | None | 501 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 497 | 7 | 2 | 3 | 3.7 | CC(C[C@@H]1C(=O)N[C@@H](C(=O)N1[C@H](c1ccc(cc1F)F)C(=O)NC(C)C)C1Cc2c(C1)cccc2)C | 10.1021/jm060073e | |||
| 6918854 | 2222 | 0 | None | 501 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 497 | 7 | 2 | 3 | 3.7 | CC(C[C@@H]1C(=O)N[C@@H](C(=O)N1[C@H](c1ccc(cc1F)F)C(=O)NC(C)C)C1Cc2c(C1)cccc2)C | 10.1021/jm060073e | |||
| CHEMBL196478 | 2222 | 0 | None | 501 | 3 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 497 | 7 | 2 | 3 | 3.7 | CC(C[C@@H]1C(=O)N[C@@H](C(=O)N1[C@H](c1ccc(cc1F)F)C(=O)NC(C)C)C1Cc2c(C1)cccc2)C | 10.1021/jm060073e | |||
| 11685100 | 161073 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 525 | 6 | 1 | 4 | 3.0 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1ccc(F)cc1F | 10.1021/jm060073e | |||
| CHEMBL211443 | 161073 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 525 | 6 | 1 | 4 | 3.0 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1ccc(F)cc1F | 10.1021/jm060073e | |||
| 56950169 | 156998 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 462 | 6 | 2 | 4 | 2.6 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC)c1cc(C)cnc1C | 10.1021/jm201287w | |||
| CHEMBL2037503 | 156998 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 462 | 6 | 2 | 4 | 2.6 | CC[C@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC)c1cc(C)cnc1C | 10.1021/jm201287w | |||
| 42611262 | 354432 | 0 | None | 31 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 349 | 6 | 0 | 2 | 4.7 | Cc1cc(C(=O)N(CC2CC2)CC2CCCO2)ccc1-c1ccccc1 | 10.1016/j.bmcl.2008.11.064 | |||
| CHEMBL475395 | 354432 | 0 | None | 31 | 4 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 349 | 6 | 0 | 2 | 4.7 | Cc1cc(C(=O)N(CC2CC2)CC2CCCO2)ccc1-c1ccccc1 | 10.1016/j.bmcl.2008.11.064 | |||
| CHEMBL2112248 | 485096 | 0 | None | -1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 754 | 6 | 5 | 8 | 1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCC=NN2C1=O | 10.1021/jm00099a019 | |||
| CHEMBL2112248 | 485096 | 0 | None | 1 | 2 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 754 | 6 | 5 | 8 | 1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCC=NN2C1=O | 10.1021/jm00099a019 | |||
| CHEMBL3814633 | 487604 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1020 | 17 | 11 | 15 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | |||
| 10699322 | 468600 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 640 | 7 | 0 | 7 | 5.2 | COc1cc(OC2CCN(Cc3ccc[n+]([O-])c3C(F)(F)F)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL66931 | 468600 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 640 | 7 | 0 | 7 | 5.2 | COc1cc(OC2CCN(Cc3ccc[n+]([O-])c3C(F)(F)F)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 9938406 | 184110 | 1 | None | -1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 589 | 7 | 0 | 6 | 4.7 | CC(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)c(OCC(F)(F)F)c2)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL24526 | 184110 | 1 | None | -1 | 6 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 589 | 7 | 0 | 6 | 4.7 | CC(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)c(OCC(F)(F)F)c2)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| 18700187 | 199084 | 0 | None | 1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 577 | 9 | 0 | 7 | 4.0 | O=C(Cc1ccc(OCCN2CCOCC2)cc1OCC(F)(F)F)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL278818 | 199084 | 0 | None | 1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 577 | 9 | 0 | 7 | 4.0 | O=C(Cc1ccc(OCCN2CCOCC2)cc1OCC(F)(F)F)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| 118720268 | 234776 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 991 | 21 | 12 | 14 | -3.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | |||
| CHEMBL3354579 | 234776 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 991 | 21 | 12 | 14 | -3.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCCSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | |||
| 155565903 | 349729 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1024 | 21 | 13 | 16 | -4.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | |||
| CHEMBL4583231 | 349729 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1024 | 21 | 13 | 16 | -4.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | |||
| 44297525 | 197135 | 0 | None | -7 | 3 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1329 | 38 | 15 | 16 | -1.8 | CN(C(=O)CCc1cccc(N=[N+]=[N-])c1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | 10.1021/jm00038a013 | |||
| CHEMBL265048 | 197135 | 0 | None | -7 | 3 | Rat | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1329 | 38 | 15 | 16 | -1.8 | CN(C(=O)CCc1cccc(N=[N+]=[N-])c1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | 10.1021/jm00038a013 | |||
| 10817776 | 468809 | 0 | None | 5 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 628 | 8 | 0 | 7 | 5.3 | CCc1c(CN2CCC(Oc3ccc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)c(OC)c3)CC2)c(C)cc(C)[n+]1[O-] | 10.1021/jm9800797 | |||
| CHEMBL68480 | 468809 | 0 | None | 5 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 628 | 8 | 0 | 7 | 5.3 | CCc1c(CN2CCC(Oc3ccc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)c(OC)c3)CC2)c(C)cc(C)[n+]1[O-] | 10.1021/jm9800797 | |||
| 73346893 | 180194 | 0 | None | None | None | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 989 | 17 | 12 | 14 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](N)CCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| CHEMBL2369425 | 180194 | 0 | None | None | None | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 989 | 17 | 12 | 14 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](N)CCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| 44456070 | 311306 | 0 | None | None | None | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 464 | 6 | 1 | 5 | 2.4 | Cc1nc([C@H](C(=O)N2CCC2)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)co1 | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL403149 | 311306 | 0 | None | None | None | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 464 | 6 | 1 | 5 | 2.4 | Cc1nc([C@H](C(=O)N2CCC2)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)co1 | 10.1016/j.bmcl.2007.11.008 | |||
| 44581267 | 348857 | 0 | None | None | None | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 505 | 9 | 0 | 7 | 4.9 | COc1ccc(OC)c(S(=O)(=O)N(Cc2ccc(-c3ccccc3C)cn2)c2ccc(OC)nc2)c1 | 10.1016/j.bmcl.2008.11.018 | |||
| CHEMBL456254 | 348857 | 0 | None | None | None | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 505 | 9 | 0 | 7 | 4.9 | COc1ccc(OC)c(S(=O)(=O)N(Cc2ccc(-c3ccccc3C)cn2)c2ccc(OC)nc2)c1 | 10.1016/j.bmcl.2008.11.018 | |||
| 44413575 | 331151 | 0 | None | None | None | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 546 | 8 | 2 | 5 | 3.2 | CC[C@@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(N2CCOCC2)cc1 | 10.1021/jm060073e | |||
| CHEMBL427227 | 331151 | 0 | None | None | None | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 546 | 8 | 2 | 5 | 3.2 | CC[C@@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(N2CCOCC2)cc1 | 10.1021/jm060073e | |||
| 11519207 | 271035 | 0 | None | None | None | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 518 | 8 | 3 | 4 | 3.4 | CC(=O)Nc1ccc([C@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| 11577215 | 271035 | 0 | None | None | None | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 518 | 8 | 3 | 4 | 3.4 | CC(=O)Nc1ccc([C@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| CHEMBL371008 | 271035 | 0 | None | None | None | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 518 | 8 | 3 | 4 | 3.4 | CC(=O)Nc1ccc([C@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| CHEMBL372619 | 271035 | 0 | None | None | None | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 518 | 8 | 3 | 4 | 3.4 | CC(=O)Nc1ccc([C@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| 56949905 | 156986 | 0 | None | None | None | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 2.7 | Cc1ccc([C@H](C(=O)N(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cn1 | 10.1021/jm201287w | |||
| CHEMBL2037491 | 156986 | 0 | None | None | None | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 2.7 | Cc1ccc([C@H](C(=O)N(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cn1 | 10.1021/jm201287w | |||
| 135399831 | 160552 | 0 | None | 1 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 597 | 11 | 2 | 8 | 2.7 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)NC(=O)c3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113189 | 160552 | 0 | None | 1 | 3 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 597 | 11 | 2 | 8 | 2.7 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)NC(=O)c3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| 10461270 | 7472 | 18 | None | -2 | 5 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 603 | 9 | 0 | 5 | 6.9 | CCN(C(=O)c1ccc(c(c1)[C@@]1(C)c2cc(Cl)ccc2N(C1=O)Cc1ccc(cc1OC)OC)Cl)Cc1cccnc1 | 10.1021/jm901812z | |||
| 2201 | 7472 | 18 | None | -2 | 5 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 603 | 9 | 0 | 5 | 6.9 | CCN(C(=O)c1ccc(c(c1)[C@@]1(C)c2cc(Cl)ccc2N(C1=O)Cc1ccc(cc1OC)OC)Cl)Cc1cccnc1 | 10.1021/jm901812z | |||
| CHEMBL1615640 | 7472 | 18 | None | -2 | 5 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 603 | 9 | 0 | 5 | 6.9 | CCN(C(=O)c1ccc(c(c1)[C@@]1(C)c2cc(Cl)ccc2N(C1=O)Cc1ccc(cc1OC)OC)Cl)Cc1cccnc1 | 10.1021/jm901812z | |||
| CHEMBL2372927 | 485915 | 0 | None | 199 | 2 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 766 | 6 | 4 | 7 | 2.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H]2CCCN2C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]2CCCCN2C(=O)[C@@H]2CCCCN2C1=O | 10.1021/jm00169a001 | |||
| 44275524 | 316842 | 0 | None | -9 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1471 | 34 | 14 | 20 | 1.1 | CN(C(=O)CCc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N(C(=O)c1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21)[C@@H](CCCCN)C(N)=O | 10.1021/jm9804782 | |||
| 91931053 | 316842 | 0 | None | -9 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1471 | 34 | 14 | 20 | 1.1 | CN(C(=O)CCc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N(C(=O)c1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21)[C@@H](CCCCN)C(N)=O | 10.1021/jm9804782 | |||
| CHEMBL412210 | 316842 | 0 | None | -9 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1471 | 34 | 14 | 20 | 1.1 | CN(C(=O)CCc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N(C(=O)c1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21)[C@@H](CCCCN)C(N)=O | 10.1021/jm9804782 | |||
| 146681949 | 8624 | 35 | None | -5 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm3006146 | |||
| 2168 | 8624 | 35 | None | -5 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm3006146 | |||
| 2810 | 8624 | 35 | None | -5 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm3006146 | |||
| 644077 | 8624 | 35 | None | -5 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm3006146 | |||
| CHEMBL373742 | 8624 | 35 | None | -5 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm3006146 | |||
| DB00067 | 8624 | 35 | None | -5 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm3006146 | |||
| P01185 | 8624 | 35 | None | -5 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm3006146 | |||
| P01186 | 8624 | 35 | None | -5 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm3006146 | |||
| P35455 | 8624 | 35 | None | -5 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm3006146 | |||
| 2042 | 8014 | 41 | None | 1 | 6 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm9607156 | |||
| 2176 | 8014 | 41 | None | 1 | 6 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm9607156 | |||
| 439302 | 8014 | 41 | None | 1 | 6 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm9607156 | |||
| CHEMBL395429 | 8014 | 41 | None | 1 | 6 | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm9607156 | |||
| 10675476 | 461752 | 0 | None | 5 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 630 | 6 | 0 | 7 | 5.2 | COc1cc(OC2CCN([C@H]3CCCc4c3ccc[n+]4[O-])CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL68800 | 461752 | 0 | None | 5 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 630 | 6 | 0 | 7 | 5.2 | COc1cc(OC2CCN([C@H]3CCCc4c3ccc[n+]4[O-])CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 146681949 | 8624 | 35 | None | -5 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm1016208 | |||
| 2168 | 8624 | 35 | None | -5 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm1016208 | |||
| 2810 | 8624 | 35 | None | -5 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm1016208 | |||
| 644077 | 8624 | 35 | None | -5 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm1016208 | |||
| CHEMBL373742 | 8624 | 35 | None | -5 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm1016208 | |||
| DB00067 | 8624 | 35 | None | -5 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm1016208 | |||
| P01185 | 8624 | 35 | None | -5 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm1016208 | |||
| P01186 | 8624 | 35 | None | -5 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm1016208 | |||
| P35455 | 8624 | 35 | None | -5 | 8 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm1016208 | |||
| 56675151 | 125938 | 0 | None | 14 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1295 | 17 | 14 | 20 | 0.7 | CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](C(C)O)NC1=O | 10.1021/jm010526+ | |||
| CHEMBL1790728 | 125938 | 0 | None | 14 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1295 | 17 | 14 | 20 | 0.7 | CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)NCN)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](C(C)O)NC1=O | 10.1021/jm010526+ | |||
| 11169 | 1650 | 39 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b01691 | |||
| 165708555 | 1650 | 39 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b01691 | |||
| 16681432 | 1650 | 39 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b01691 | |||
| 495 | 1650 | 39 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b01691 | |||
| CHEMBL3301668 | 1650 | 39 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b01691 | |||
| DB01282 | 1650 | 39 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | 10.1021/acs.jmedchem.8b01691 | |||
| 44428109 | 24609 | 0 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1629 | 38 | 18 | 23 | -0.0 | CN(C(=O)CCc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CC[C@H](C(=O)N(C(=O)c2ccc(-c3c4ccc(=N)c(S(=O)(=O)O)c-4oc4c(S(=O)(=O)O)c(N)ccc34)c(C(=O)O)c2)[C@@H](CCCCN)C(N)=O)C1 | 10.1021/jm061404q | |||
| 91935618 | 24609 | 0 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1629 | 38 | 18 | 23 | -0.0 | CN(C(=O)CCc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CC[C@H](C(=O)N(C(=O)c2ccc(-c3c4ccc(=N)c(S(=O)(=O)O)c-4oc4c(S(=O)(=O)O)c(N)ccc34)c(C(=O)O)c2)[C@@H](CCCCN)C(N)=O)C1 | 10.1021/jm061404q | |||
| CHEMBL1161979 | 24609 | 0 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1629 | 38 | 18 | 23 | -0.0 | CN(C(=O)CCc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CC[C@H](C(=O)N(C(=O)c2ccc(-c3c4ccc(=N)c(S(=O)(=O)O)c-4oc4c(S(=O)(=O)O)c(N)ccc34)c(C(=O)O)c2)[C@@H](CCCCN)C(N)=O)C1 | 10.1021/jm061404q | |||
| 11260438 | 197937 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | Cc1nc([C@H](C(=O)N2CCOCC2)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)co1 | 10.1016/j.bmcl.2007.11.008 | |||
| 44577873 | 197937 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | Cc1nc([C@H](C(=O)N2CCOCC2)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)co1 | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL271039 | 197937 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | Cc1nc([C@H](C(=O)N2CCOCC2)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)co1 | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL513488 | 197937 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | Cc1nc([C@H](C(=O)N2CCOCC2)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)co1 | 10.1016/j.bmcl.2007.11.008 | |||
| 44456424 | 315524 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 545 | 7 | 2 | 4 | 4.2 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(Br)s1 | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL410420 | 315524 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 545 | 7 | 2 | 4 | 4.2 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(Br)s1 | 10.1016/j.bmcl.2007.11.008 | |||
| 44279908 | 199783 | 0 | None | 794 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 585 | 8 | 1 | 9 | 3.5 | CCOc1ccn(CC(=O)NCc2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)c(=O)n1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL283894 | 199783 | 0 | None | 794 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 585 | 8 | 1 | 9 | 3.5 | CCOc1ccn(CC(=O)NCc2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)c(=O)n1 | 10.1016/s0960-894x(02)00160-9 | |||
| 10416272 | 214451 | 4 | None | 630 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 608 | 6 | 1 | 7 | 4.7 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL31065 | 214451 | 4 | None | 630 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 608 | 6 | 1 | 7 | 4.7 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| 11685194 | 272701 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 532 | 7 | 3 | 4 | 3.8 | CC(=O)Nc1ccc([C@H](C(=O)NC(C)(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| CHEMBL372554 | 272701 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 532 | 7 | 3 | 4 | 3.8 | CC(=O)Nc1ccc([C@H](C(=O)NC(C)(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| 21886866 | 272712 | 17 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 135 | 0 | 1 | 2 | 1.1 | c1ccc2c(c1)CNCO2 | 10.1021/jm050557v | |||
| CHEMBL372615 | 272712 | 17 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 135 | 0 | 1 | 2 | 1.1 | c1ccc2c(c1)CNCO2 | 10.1021/jm050557v | |||
| 2252 | 4546 | 39 | None | -1 | 5 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/s0960-894x(02)00159-2 | |||
| 6918320 | 4546 | 39 | None | -1 | 5 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL24781 | 4546 | 39 | None | -1 | 5 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/s0960-894x(02)00159-2 | |||
| 44279637 | 220934 | 0 | None | None | None | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 550 | 5 | 0 | 6 | 4.1 | Cc1cc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)cc2ccn(C[C@H]3CCCN3S(C)(=O)=O)c12 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL32745 | 220934 | 0 | None | None | None | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 550 | 5 | 0 | 6 | 4.1 | Cc1cc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)cc2ccn(C[C@H]3CCCN3S(C)(=O)=O)c12 | 10.1016/s0960-894x(02)00159-2 | |||
| 44308876 | 468866 | 0 | None | 2 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 556 | 7 | 0 | 7 | 4.9 | COc1cc(OC2CCN(Cc3cccnc3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL68914 | 468866 | 0 | None | 2 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 556 | 7 | 0 | 7 | 4.9 | COc1cc(OC2CCN(Cc3cccnc3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 44581687 | 349592 | 0 | None | None | None | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 445 | 7 | 0 | 5 | 4.9 | COc1ccc(N(Cc2ccc(-c3ccccc3C)cn2)S(=O)(=O)c2ccccc2)cn1 | 10.1016/j.bmcl.2008.11.018 | |||
| CHEMBL457998 | 349592 | 0 | None | None | None | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 445 | 7 | 0 | 5 | 4.9 | COc1ccc(N(Cc2ccc(-c3ccccc3C)cn2)S(=O)(=O)c2ccccc2)cn1 | 10.1016/j.bmcl.2008.11.018 | |||
| 44581240 | 372840 | 0 | None | 6 | 3 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 486 | 8 | 0 | 7 | 4.4 | COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3C#N)cn2)c2ccc(OC)nc2)cc1 | 10.1016/j.bmcl.2008.11.018 | |||
| CHEMBL515660 | 372840 | 0 | None | 6 | 3 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 486 | 8 | 0 | 7 | 4.4 | COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3C#N)cn2)c2ccc(OC)nc2)cc1 | 10.1016/j.bmcl.2008.11.018 | |||
| 44279573 | 199363 | 0 | None | None | None | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 625 | 6 | 1 | 8 | 4.6 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1nc2ccc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc2s1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL281081 | 199363 | 0 | None | None | None | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 625 | 6 | 1 | 8 | 4.6 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1nc2ccc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc2s1 | 10.1016/s0960-894x(02)00160-9 | |||
| 44279846 | 199767 | 0 | None | None | None | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 648 | 6 | 0 | 7 | 6.4 | O=C(c1ccc2oc(CN3CCCC[C@H]3Cn3cc(C(F)(F)F)ccc3=O)cc2c1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL283676 | 199767 | 0 | None | None | None | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 648 | 6 | 0 | 7 | 6.4 | O=C(c1ccc2oc(CN3CCCC[C@H]3Cn3cc(C(F)(F)F)ccc3=O)cc2c1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00160-9 | |||
| 44280354 | 335700 | 0 | None | None | None | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 628 | 5 | 0 | 7 | 6.5 | O=C(c1ccc2oc(-c3cccc(Cn4cc(C(F)(F)F)ccc4=O)n3)cc2c1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL445875 | 335700 | 0 | None | None | None | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 628 | 5 | 0 | 7 | 6.5 | O=C(c1ccc2oc(-c3cccc(Cn4cc(C(F)(F)F)ccc4=O)n3)cc2c1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00160-9 | |||
| 135520376 | 160567 | 0 | None | 138 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 526 | 9 | 2 | 6 | 3.8 | CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113209 | 160567 | 0 | None | 138 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 526 | 9 | 2 | 6 | 3.8 | CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| 44404012 | 142664 | 0 | None | None | None | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 539 | 8 | 2 | 5 | 2.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(S(C)(=O)=O)cc1 | 10.1021/jm050557v | |||
| 44404027 | 142664 | 0 | None | None | None | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 539 | 8 | 2 | 5 | 2.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(S(C)(=O)=O)cc1 | 10.1021/jm050557v | |||
| CHEMBL194584 | 142664 | 0 | None | None | None | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 539 | 8 | 2 | 5 | 2.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(S(C)(=O)=O)cc1 | 10.1021/jm050557v | |||
| CHEMBL197833 | 142664 | 0 | None | None | None | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 539 | 8 | 2 | 5 | 2.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(S(C)(=O)=O)cc1 | 10.1021/jm050557v | |||
| 70685417 | 155339 | 0 | None | 79 | 3 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 707 | 9 | 0 | 6 | 4.3 | CS(=O)(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)CCc5ccccc54)CC3)c(OC/C=C/I)c2)CC1 | 10.1016/j.bmc.2012.02.019 | |||
| CHEMBL2017867 | 155339 | 0 | None | 79 | 3 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 707 | 9 | 0 | 6 | 4.3 | CS(=O)(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)CCc5ccccc54)CC3)c(OC/C=C/I)c2)CC1 | 10.1016/j.bmc.2012.02.019 | |||
| 11465834 | 275790 | 0 | None | -23 | 4 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 483 | 6 | 1 | 3 | 3.3 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(F)cc1F | 10.1021/jm060073e | |||
| CHEMBL377414 | 275790 | 0 | None | -23 | 4 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 483 | 6 | 1 | 3 | 3.3 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(F)cc1F | 10.1021/jm060073e | |||
| 135520376 | 160567 | 0 | None | 138 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 526 | 9 | 2 | 6 | 3.8 | CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1039/C5MD00566C | |||
| CHEMBL2113209 | 160567 | 0 | None | 138 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 526 | 9 | 2 | 6 | 3.8 | CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1039/C5MD00566C | |||
| 67839485 | 329150 | 0 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 327 | 2 | 0 | 1 | 5.3 | O=C(c1ccc(-c2ccccc2)cc1)N1CCCCc2ccccc21 | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL4210854 | 329150 | 0 | None | -4 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 327 | 2 | 0 | 1 | 5.3 | O=C(c1ccc(-c2ccccc2)cc1)N1CCCCc2ccccc21 | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL3813722 | 487593 | 0 | None | None | None | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 1034 | 17 | 10 | 15 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | |||
| 44279688 | 200303 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 626 | 6 | 1 | 7 | 4.8 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5c(F)cccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL287628 | 200303 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 626 | 6 | 1 | 7 | 4.8 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5c(F)cccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| 44279997 | 202882 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 608 | 6 | 1 | 7 | 4.7 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2ccc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL30550 | 202882 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 608 | 6 | 1 | 7 | 4.7 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2ccc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| 1134581 | 24197 | 7 | None | 3 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 444 | 7 | 1 | 4 | 4.5 | COc1ccc(N(CC(=O)Nc2cccc(Cl)c2C)S(=O)(=O)c2ccccc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL114302 | 24197 | 7 | None | 3 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 444 | 7 | 1 | 4 | 4.5 | COc1ccc(N(CC(=O)Nc2cccc(Cl)c2C)S(=O)(=O)c2ccccc2)cc1 | 10.1021/jm050645f | |||
| 44404012 | 142664 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 539 | 8 | 2 | 5 | 2.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(S(C)(=O)=O)cc1 | 10.1021/jm050557v | |||
| 44404027 | 142664 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 539 | 8 | 2 | 5 | 2.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(S(C)(=O)=O)cc1 | 10.1021/jm050557v | |||
| CHEMBL194584 | 142664 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 539 | 8 | 2 | 5 | 2.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(S(C)(=O)=O)cc1 | 10.1021/jm050557v | |||
| CHEMBL197833 | 142664 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 539 | 8 | 2 | 5 | 2.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(S(C)(=O)=O)cc1 | 10.1021/jm050557v | |||
| 11569194 | 144330 | 0 | None | 63 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 479 | 7 | 2 | 3 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(F)cc1 | 10.1021/jm050557v | |||
| 11619939 | 144330 | 0 | None | 63 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 479 | 7 | 2 | 3 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(F)cc1 | 10.1021/jm050557v | |||
| CHEMBL197793 | 144330 | 0 | None | 63 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 479 | 7 | 2 | 3 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(F)cc1 | 10.1021/jm050557v | |||
| CHEMBL427353 | 144330 | 0 | None | 63 | 2 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 479 | 7 | 2 | 3 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(F)cc1 | 10.1021/jm050557v | |||
| 44275026 | 182394 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 488 | 7 | 2 | 4 | 3.3 | CC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)NCCc2cccc(Cl)c2)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL24074 | 182394 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 488 | 7 | 2 | 4 | 3.3 | CC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)NCCc2cccc(Cl)c2)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| 44274724 | 193876 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 522 | 7 | 2 | 4 | 4.0 | CC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)NCCc2ccc(Cl)c(Cl)c2)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL24605 | 193876 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 522 | 7 | 2 | 4 | 4.0 | CC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)NCCc2ccc(Cl)c(Cl)c2)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| 44274675 | 194063 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 572 | 12 | 2 | 5 | 4.5 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)NCCCc2cccc(Cl)c2)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL24678 | 194063 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 572 | 12 | 2 | 5 | 4.5 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)NCCCc2cccc(Cl)c2)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| 44274994 | 194327 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 504 | 7 | 2 | 4 | 3.8 | CC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)NCCc2cccc3ccccc23)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL24816 | 194327 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 504 | 7 | 2 | 4 | 3.8 | CC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)NCCc2cccc3ccccc23)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| 9797987 | 237306 | 1 | None | 1 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 339 | 2 | 0 | 2 | 3.7 | Cc1ccc(S(=O)(=O)N2CCC3(C=Cc4ccccc43)CC2)cc1 | 10.1021/jm901812z | |||
| CHEMBL341490 | 237306 | 1 | None | 1 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 339 | 2 | 0 | 2 | 3.7 | Cc1ccc(S(=O)(=O)N2CCC3(C=Cc4ccccc43)CC2)cc1 | 10.1021/jm901812z | |||
| 56682530 | 125921 | 0 | None | -245 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 1053 | 18 | 12 | 14 | -2.6 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| CHEMBL1790575 | 125921 | 0 | None | -245 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 1053 | 18 | 12 | 14 | -2.6 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| CHEMBL2369841 | 477601 | 0 | None | -301 | 4 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 1026 | 17 | 13 | 15 | -4.6 | NC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| 135510027 | 278317 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 524 | 7 | 2 | 5 | 6.4 | Cc1ccc(N(CC(=O)/N=N/c2c(O)[nH]c3ccccc23)S(=O)(=O)c2ccc(-c3ccccc3)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL382515 | 278317 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 524 | 7 | 2 | 5 | 6.4 | Cc1ccc(N(CC(=O)/N=N/c2c(O)[nH]c3ccccc23)S(=O)(=O)c2ccc(-c3ccccc3)cc2)cc1 | 10.1021/jm050645f | |||
| 145976648 | 328808 | 0 | None | -1 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 293 | 3 | 0 | 1 | 4.6 | CCCc1ccc(C(=O)N2CCCCc3ccccc32)cc1 | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL4206482 | 328808 | 0 | None | -1 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 293 | 3 | 0 | 1 | 4.6 | CCCc1ccc(C(=O)N2CCCCc3ccccc32)cc1 | 10.1021/acs.jmedchem.8b00697 | |||
| 44419039 | 274799 | 0 | None | -8511 | 8 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 1096 | 20 | 14 | 15 | -4.6 | NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm030611c | |||
| CHEMBL375324 | 274799 | 0 | None | -8511 | 8 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 1096 | 20 | 14 | 15 | -4.6 | NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm030611c | |||
| 135489430 | 160554 | 0 | None | 11 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 627 | 12 | 2 | 9 | 3.1 | COC(=O)c1cccc2c1NC(=O)/C2=N\NC(=O)CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(OCCCN(C)C)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113195 | 160554 | 0 | None | 11 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 627 | 12 | 2 | 9 | 3.1 | COC(=O)c1cccc2c1NC(=O)/C2=N\NC(=O)CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(OCCCN(C)C)cc1 | 10.1021/jm050645f | |||
| 10411308 | 462175 | 0 | None | -39 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 446 | 4 | 1 | 2 | 6.6 | O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1-c1ccccc1 | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL603708 | 462175 | 0 | None | -39 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 446 | 4 | 1 | 2 | 6.6 | O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1-c1ccccc1 | 10.1021/acs.jmedchem.8b00697 | |||
| 10411308 | 462175 | 0 | None | -39 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 446 | 4 | 1 | 2 | 6.6 | O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1-c1ccccc1 | 10.1021/jm3006146 | |||
| CHEMBL603708 | 462175 | 0 | None | -39 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 446 | 4 | 1 | 2 | 6.6 | O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1-c1ccccc1 | 10.1021/jm3006146 | |||
| 10411308 | 462175 | 0 | None | -39 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 446 | 4 | 1 | 2 | 6.6 | O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1-c1ccccc1 | 10.1021/jm901084f | |||
| CHEMBL603708 | 462175 | 0 | None | -39 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 446 | 4 | 1 | 2 | 6.6 | O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1-c1ccccc1 | 10.1021/jm901084f | |||
| 10507277 | 468944 | 0 | None | 2 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 570 | 7 | 0 | 7 | 5.2 | COc1cc(OC2CCN(Cc3cccnc3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL69520 | 468944 | 0 | None | 2 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 570 | 7 | 0 | 7 | 5.2 | COc1cc(OC2CCN(Cc3cccnc3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 10793202 | 468947 | 0 | None | 2 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 572 | 7 | 0 | 7 | 4.1 | COc1cc(OC2CCN(Cc3ccc[n+]([O-])c3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL69539 | 468947 | 0 | None | 2 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 572 | 7 | 0 | 7 | 4.1 | COc1cc(OC2CCN(Cc3ccc[n+]([O-])c3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 10507800 | 468517 | 0 | None | -5 | 2 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 600 | 8 | 0 | 7 | 4.7 | CCc1c(CN2CCC(Oc3ccc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)c(OC)c3)CC2)ccc[n+]1[O-] | 10.1021/jm9800797 | |||
| CHEMBL66240 | 468517 | 0 | None | -5 | 2 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 600 | 8 | 0 | 7 | 4.7 | CCc1c(CN2CCC(Oc3ccc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)c(OC)c3)CC2)ccc[n+]1[O-] | 10.1021/jm9800797 | |||
| 2213 | 1072 | 37 | None | -22 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2007.11.008 | |||
| 3008 | 1072 | 37 | None | -22 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2007.11.008 | |||
| 5311010 | 1072 | 37 | None | -22 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2007.11.008 | |||
| 68613 | 1072 | 37 | None | -22 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL378642 | 1072 | 37 | None | -22 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL382301 | 1072 | 37 | None | -22 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2007.11.008 | |||
| DB09059 | 1072 | 37 | None | -22 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2007.11.008 | |||
| 53320505 | 119140 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1074 | 17 | 12 | 13 | -4.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)C[Se][Se]C[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| CHEMBL1630524 | 119140 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1074 | 17 | 12 | 13 | -4.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)C[Se][Se]C[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| 135513039 | 160563 | 0 | None | 63 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 473 | 6 | 2 | 6 | 2.5 | Cc1ccc(N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)S(=O)(=O)c2ccc(C#N)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113205 | 160563 | 0 | None | 63 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 473 | 6 | 2 | 6 | 2.5 | Cc1ccc(N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)S(=O)(=O)c2ccc(C#N)cc2)cc1 | 10.1021/jm050645f | |||
| 135916059 | 451719 | 0 | None | -16 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 513 | 4 | 2 | 5 | 6.6 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1NC(=O)c1ccccc1-c1ccccc1 | 10.1021/jm901084f | |||
| CHEMBL602872 | 451719 | 0 | None | -16 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 513 | 4 | 2 | 5 | 6.6 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1NC(=O)c1ccccc1-c1ccccc1 | 10.1021/jm901084f | |||
| CHEMBL3814126 | 487599 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 1020 | 17 | 11 | 15 | -3.3 | CC[C@H](C)[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1C | 10.1016/j.bmc.2016.05.062 | |||
| 135530164 | 160558 | 0 | None | 1 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 570 | 11 | 2 | 8 | 2.7 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccncc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113200 | 160558 | 0 | None | 1 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 570 | 11 | 2 | 8 | 2.7 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccncc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| 54581533 | 125127 | 0 | None | -57 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 636 | 9 | 0 | 9 | 5.2 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3cc(CN(C)C)ccc3OC)(N3CCC[C@H]3c3ncco3)c3cc(Cl)ccc32)cc1 | 10.1016/j.bmcl.2011.03.012 | |||
| CHEMBL1779418 | 125127 | 0 | None | -57 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 636 | 9 | 0 | 9 | 5.2 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3cc(CN(C)C)ccc3OC)(N3CCC[C@H]3c3ncco3)c3cc(Cl)ccc32)cc1 | 10.1016/j.bmcl.2011.03.012 | |||
| 10005688 | 19410 | 0 | None | -2 | 2 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 487 | 6 | 0 | 6 | 5.0 | COc1cc(OC(C)c2cccnc2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL105406 | 19410 | 0 | None | -2 | 2 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 487 | 6 | 0 | 6 | 5.0 | COc1cc(OC(C)c2cccnc2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| 10841081 | 202393 | 0 | None | -3 | 2 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 586 | 7 | 0 | 7 | 4.4 | COc1cc(OC2CCN(Cc3c[n+]([O-])ccc3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL303487 | 202393 | 0 | None | -3 | 2 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 586 | 7 | 0 | 7 | 4.4 | COc1cc(OC2CCN(Cc3c[n+]([O-])ccc3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 10651439 | 202957 | 0 | None | -2 | 2 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 614 | 7 | 0 | 7 | 5.1 | COc1cc(OC2CCN(Cc3c(C)cc(C)[n+]([O-])c3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL306010 | 202957 | 0 | None | -2 | 2 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 614 | 7 | 0 | 7 | 5.1 | COc1cc(OC2CCN(Cc3c(C)cc(C)[n+]([O-])c3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 135414531 | 160566 | 0 | None | -3 | 3 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 586 | 13 | 2 | 8 | 3.1 | COCCOCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113208 | 160566 | 0 | None | -3 | 3 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 586 | 13 | 2 | 8 | 3.1 | COCCOCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| 146681949 | 8624 | 35 | None | -5 | 8 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm100989w | |||
| 2168 | 8624 | 35 | None | -5 | 8 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm100989w | |||
| 2810 | 8624 | 35 | None | -5 | 8 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm100989w | |||
| 644077 | 8624 | 35 | None | -5 | 8 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm100989w | |||
| CHEMBL373742 | 8624 | 35 | None | -5 | 8 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm100989w | |||
| DB00067 | 8624 | 35 | None | -5 | 8 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm100989w | |||
| P01185 | 8624 | 35 | None | -5 | 8 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm100989w | |||
| P01186 | 8624 | 35 | None | -5 | 8 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm100989w | |||
| P35455 | 8624 | 35 | None | -5 | 8 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/jm100989w | |||
| 44456072 | 198020 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 465 | 6 | 2 | 4 | 3.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccoc1 | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL271456 | 198020 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 465 | 6 | 2 | 4 | 3.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccoc1 | 10.1016/j.bmcl.2007.11.008 | |||
| 25212177 | 348862 | 6 | None | 7 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 463 | 7 | 0 | 7 | 3.9 | COc1ccc(N(Cc2ccc(-c3ccccc3C)cn2)S(=O)(=O)c2cn(C)c(C)n2)cn1 | 10.1016/j.bmcl.2008.11.018 | |||
| CHEMBL456263 | 348862 | 6 | None | 7 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 463 | 7 | 0 | 7 | 3.9 | COc1ccc(N(Cc2ccc(-c3ccccc3C)cn2)S(=O)(=O)c2cn(C)c(C)n2)cn1 | 10.1016/j.bmcl.2008.11.018 | |||
| 44581241 | 349862 | 0 | None | 3 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 495 | 8 | 0 | 6 | 5.2 | COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3Cl)cn2)c2ccc(OC)nc2)cc1 | 10.1016/j.bmcl.2008.11.018 | |||
| CHEMBL458634 | 349862 | 0 | None | 3 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 495 | 8 | 0 | 6 | 5.2 | COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3Cl)cn2)c2ccc(OC)nc2)cc1 | 10.1016/j.bmcl.2008.11.018 | |||
| 44581719 | 349869 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 451 | 7 | 0 | 6 | 4.9 | COc1ccc(N(Cc2ccc(-c3ccccc3C)cn2)S(=O)(=O)c2cccs2)cn1 | 10.1016/j.bmcl.2008.11.018 | |||
| CHEMBL458654 | 349869 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 451 | 7 | 0 | 6 | 4.9 | COc1ccc(N(Cc2ccc(-c3ccccc3C)cn2)S(=O)(=O)c2cccs2)cn1 | 10.1016/j.bmcl.2008.11.018 | |||
| 44581720 | 349956 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 523 | 8 | 0 | 7 | 4.3 | COc1ccc(N(Cc2ccc(-c3ccccc3C)cn2)S(=O)(=O)c2cccc(S(C)(=O)=O)c2)cn1 | 10.1016/j.bmcl.2008.11.018 | |||
| CHEMBL458872 | 349956 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 523 | 8 | 0 | 7 | 4.3 | COc1ccc(N(Cc2ccc(-c3ccccc3C)cn2)S(=O)(=O)c2cccc(S(C)(=O)=O)c2)cn1 | 10.1016/j.bmcl.2008.11.018 | |||
| 44581718 | 372649 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 480 | 7 | 0 | 7 | 4.9 | COc1ccc(N(Cc2ccc(-c3ccccc3C)cn2)S(=O)(=O)c2sc(C)nc2C)cn1 | 10.1016/j.bmcl.2008.11.018 | |||
| CHEMBL514123 | 372649 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 480 | 7 | 0 | 7 | 4.9 | COc1ccc(N(Cc2ccc(-c3ccccc3C)cn2)S(=O)(=O)c2sc(C)nc2C)cn1 | 10.1016/j.bmcl.2008.11.018 | |||
| 25212178 | 372873 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 449 | 7 | 0 | 7 | 3.6 | COc1ccc(N(Cc2ccc(-c3ccccc3C)cn2)S(=O)(=O)c2cn(C)cn2)cn1 | 10.1016/j.bmcl.2008.11.018 | |||
| CHEMBL515975 | 372873 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 449 | 7 | 0 | 7 | 3.6 | COc1ccc(N(Cc2ccc(-c3ccccc3C)cn2)S(=O)(=O)c2cn(C)cn2)cn1 | 10.1016/j.bmcl.2008.11.018 | |||
| 11495934 | 159620 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 442 | 6 | 2 | 3 | 3.2 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](CO)c1ccc(F)cc1F | 10.1021/jm060073e | |||
| CHEMBL209917 | 159620 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 442 | 6 | 2 | 3 | 3.2 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](CO)c1ccc(F)cc1F | 10.1021/jm060073e | |||
| 54581307 | 123944 | 0 | None | -9 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1097 | 21 | 12 | 15 | -1.4 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCN)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm1016208 | |||
| CHEMBL1765666 | 123944 | 0 | None | -9 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1097 | 21 | 12 | 15 | -1.4 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCN)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm1016208 | |||
| 44275618 | 198042 | 0 | None | -1 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 396 | 4 | 0 | 5 | 3.5 | COc1ccc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)c(OC)c1 | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL27157 | 198042 | 0 | None | -1 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 396 | 4 | 0 | 5 | 3.5 | COc1ccc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)c(OC)c1 | 10.1016/s0960-894x(98)00568-x | |||
| 44275618 | 198042 | 0 | None | -1 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 396 | 4 | 0 | 5 | 3.5 | COc1ccc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)c(OC)c1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL27157 | 198042 | 0 | None | -1 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 396 | 4 | 0 | 5 | 3.5 | COc1ccc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)c(OC)c1 | 10.1016/s0960-894x(99)00181-x | |||
| 16109439 | 274647 | 0 | None | -120 | 4 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 1023 | 15 | 11 | 14 | -1.7 | NC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm060928n | |||
| CHEMBL375187 | 274647 | 0 | None | -120 | 4 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 1023 | 15 | 11 | 14 | -1.7 | NC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm060928n | |||
| CHEMBL2372932 | 485917 | 0 | None | None | None | Rat | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 698 | 4 | 2 | 6 | 2.1 | C[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00169a001 | |||
| 3537 | 8682 | 25 | None | -3 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 402 | 2 | 0 | 4 | 4.8 | Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 | 10.1021/acs.jmedchem.8b00697 | |||
| 5311500 | 8682 | 25 | None | -3 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 402 | 2 | 0 | 4 | 4.8 | Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL363910 | 8682 | 25 | None | -3 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 402 | 2 | 0 | 4 | 4.8 | Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 | 10.1021/acs.jmedchem.8b00697 | |||
| 16109442 | 274800 | 0 | None | -208 | 4 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1068 | 20 | 14 | 15 | -3.3 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| CHEMBL375325 | 274800 | 0 | None | -208 | 4 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1068 | 20 | 14 | 15 | -3.3 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| 44279330 | 200254 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 389 | 2 | 0 | 4 | 3.9 | Cn1ccc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc21 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL287293 | 200254 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 389 | 2 | 0 | 4 | 3.9 | Cn1ccc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc21 | 10.1016/s0960-894x(02)00159-2 | |||
| 44278983 | 218020 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 434 | 3 | 0 | 6 | 4.3 | Cc1nc(-c2ccncc2)sc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL31986 | 218020 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 434 | 3 | 0 | 6 | 4.3 | Cc1nc(-c2ccncc2)sc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| 44279329 | 220932 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 389 | 2 | 1 | 3 | 4.2 | Cc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2[nH]1 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL32740 | 220932 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 389 | 2 | 1 | 3 | 4.2 | Cc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2[nH]1 | 10.1016/s0960-894x(02)00159-2 | |||
| 44581685 | 349590 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 461 | 8 | 0 | 6 | 4.6 | COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3)cn2)c2ccc(OC)nc2)cc1 | 10.1016/j.bmcl.2008.11.018 | |||
| CHEMBL457997 | 349590 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 461 | 8 | 0 | 6 | 4.6 | COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3)cn2)c2ccc(OC)nc2)cc1 | 10.1016/j.bmcl.2008.11.018 | |||
| 44279580 | 200227 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 536 | 5 | 0 | 6 | 3.8 | CS(=O)(=O)N1CCC[C@H]1Cn1ccc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc21 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL287042 | 200227 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 536 | 5 | 0 | 6 | 3.8 | CS(=O)(=O)N1CCC[C@H]1Cn1ccc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc21 | 10.1016/s0960-894x(02)00159-2 | |||
| 11519207 | 271035 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 518 | 8 | 3 | 4 | 3.4 | CC(=O)Nc1ccc([C@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| 11577215 | 271035 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 518 | 8 | 3 | 4 | 3.4 | CC(=O)Nc1ccc([C@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| CHEMBL371008 | 271035 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 518 | 8 | 3 | 4 | 3.4 | CC(=O)Nc1ccc([C@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| CHEMBL372619 | 271035 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 518 | 8 | 3 | 4 | 3.4 | CC(=O)Nc1ccc([C@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| CHEMBL2369842 | 477602 | 0 | None | -8 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1103 | 18 | 13 | 15 | -2.7 | NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm030611c | |||
| 56671721 | 125936 | 0 | None | 5 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1321 | 15 | 13 | 19 | 3.0 | CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](C(C)O)NC1=O | 10.1021/jm010526+ | |||
| CHEMBL1790722 | 125936 | 0 | None | 5 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1321 | 15 | 13 | 19 | 3.0 | CC[C@@H](C)[C@H]1NC(=O)[C@H](c2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](C(C)O)NC1=O | 10.1021/jm010526+ | |||
| 10507580 | 468850 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 586 | 7 | 0 | 7 | 4.4 | COc1cc(OC2CCN(Cc3cc(C)c[n+]([O-])c3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL68752 | 468850 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 586 | 7 | 0 | 7 | 4.4 | COc1cc(OC2CCN(Cc3cc(C)c[n+]([O-])c3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 10556286 | 469253 | 0 | None | -10 | 2 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 658 | 7 | 0 | 7 | 5.3 | COc1cc(OC2CCN(Cc3c[n+]([O-])ccc3C(F)(F)F)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL71540 | 469253 | 0 | None | -10 | 2 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 658 | 7 | 0 | 7 | 5.3 | COc1cc(OC2CCN(Cc3c[n+]([O-])ccc3C(F)(F)F)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 2249 | 4540 | 14 | None | -2 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 554 | 9 | 2 | 7 | 1.5 | O=C([C@H](CCS(=O)(=O)C)N)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ccccc1C)(C)C | 10.1016/j.bmcl.2012.10.116 | |||
| 9872389 | 4540 | 14 | None | -2 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 554 | 9 | 2 | 7 | 1.5 | O=C([C@H](CCS(=O)(=O)C)N)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ccccc1C)(C)C | 10.1016/j.bmcl.2012.10.116 | |||
| CHEMBL1253853 | 4540 | 14 | None | -2 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 554 | 9 | 2 | 7 | 1.5 | O=C([C@H](CCS(=O)(=O)C)N)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ccccc1C)(C)C | 10.1016/j.bmcl.2012.10.116 | |||
| 2249 | 4540 | 14 | None | -2 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 554 | 9 | 2 | 7 | 1.5 | O=C([C@H](CCS(=O)(=O)C)N)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ccccc1C)(C)C | 10.1021/jm901812z | |||
| 9872389 | 4540 | 14 | None | -2 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 554 | 9 | 2 | 7 | 1.5 | O=C([C@H](CCS(=O)(=O)C)N)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ccccc1C)(C)C | 10.1021/jm901812z | |||
| CHEMBL1253853 | 4540 | 14 | None | -2 | 7 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 554 | 9 | 2 | 7 | 1.5 | O=C([C@H](CCS(=O)(=O)C)N)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ccccc1C)(C)C | 10.1021/jm901812z | |||
| 44361406 | 78503 | 0 | None | -4 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 451 | 7 | 1 | 5 | 3.4 | CC(=O)NCCCOc1ccc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)cc1 | 10.1021/jm00023a002 | |||
| CHEMBL143304 | 78503 | 0 | None | -4 | 5 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 451 | 7 | 1 | 5 | 3.4 | CC(=O)NCCCOc1ccc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)cc1 | 10.1021/jm00023a002 | |||
| 44361387 | 238172 | 0 | None | -8 | 5 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 505 | 6 | 0 | 5 | 4.6 | CC(=O)N1CCCCC1CCOc1ccc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)cc1 | 10.1021/jm00023a002 | |||
| CHEMBL344752 | 238172 | 0 | None | -8 | 5 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 505 | 6 | 0 | 5 | 4.6 | CC(=O)N1CCCCC1CCOc1ccc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)cc1 | 10.1021/jm00023a002 | |||
| 16109448 | 278813 | 0 | None | -213 | 4 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1054 | 19 | 14 | 15 | -3.7 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| CHEMBL385068 | 278813 | 0 | None | -213 | 4 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1054 | 19 | 14 | 15 | -3.7 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| CHEMBL2369845 | 477603 | 0 | None | -169 | 4 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1039 | 18 | 12 | 14 | -2.8 | CCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| 145971417 | 329607 | 0 | None | -1 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 374 | 3 | 0 | 4 | 4.2 | Cc1ccn(-c2ccc(C(=O)N3CCCC(N(C)C)c4ccccc43)cc2)n1 | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL4216926 | 329607 | 0 | None | -1 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 374 | 3 | 0 | 4 | 4.2 | Cc1ccn(-c2ccc(C(=O)N3CCCC(N(C)C)c4ccccc43)cc2)n1 | 10.1021/acs.jmedchem.8b00697 | |||
| 16109446 | 274035 | 0 | None | -354 | 4 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 983 | 15 | 11 | 14 | -2.7 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| CHEMBL373968 | 274035 | 0 | None | -354 | 4 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 983 | 15 | 11 | 14 | -2.7 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| 2192 | 4802 | 27 | None | -5 | 3 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 471 | 7 | 2 | 5 | 3.7 | CO/N=C/1\CN([C@@H](C1)C(=O)NC[C@H](c1ccccc1)O)C(=O)c1ccc(cc1)c1ccccc1C | 10.1021/jm901812z | |||
| 9690136 | 4802 | 27 | None | -5 | 3 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 471 | 7 | 2 | 5 | 3.7 | CO/N=C/1\CN([C@@H](C1)C(=O)NC[C@H](c1ccccc1)O)C(=O)c1ccc(cc1)c1ccccc1C | 10.1021/jm901812z | |||
| CHEMBL1254024 | 4802 | 27 | None | -5 | 3 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 471 | 7 | 2 | 5 | 3.7 | CO/N=C/1\CN([C@@H](C1)C(=O)NC[C@H](c1ccccc1)O)C(=O)c1ccc(cc1)c1ccccc1C | 10.1021/jm901812z | |||
| 54582526 | 125128 | 0 | None | -34 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 622 | 9 | 1 | 9 | 4.9 | CNCc1ccc(OC)c([C@@]2(N3CCC[C@H]3c3ncco3)C(=O)N(S(=O)(=O)c3ccc(OC)cc3)c3ccc(Cl)cc32)c1 | 10.1016/j.bmcl.2011.03.012 | |||
| CHEMBL1779419 | 125128 | 0 | None | -34 | 3 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 622 | 9 | 1 | 9 | 4.9 | CNCc1ccc(OC)c([C@@]2(N3CCC[C@H]3c3ncco3)C(=O)N(S(=O)(=O)c3ccc(OC)cc3)c3ccc(Cl)cc32)c1 | 10.1016/j.bmcl.2011.03.012 | |||
| 44419025 | 175267 | 18 | None | -537 | 8 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1039 | 17 | 13 | 14 | -2.7 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| 44419026 | 175267 | 18 | None | -537 | 8 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1039 | 17 | 13 | 14 | -2.7 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| 74992363 | 175267 | 18 | None | -537 | 8 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1039 | 17 | 13 | 14 | -2.7 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| CHEMBL221436 | 175267 | 18 | None | -537 | 8 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1039 | 17 | 13 | 14 | -2.7 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| CHEMBL435323 | 175267 | 18 | None | -537 | 8 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1039 | 17 | 13 | 14 | -2.7 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| CHEMBL6015151 | 175267 | 18 | None | -537 | 8 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1039 | 17 | 13 | 14 | -2.7 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| CHEMBL2369836 | 477596 | 0 | None | -2570 | 4 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 1110 | 21 | 14 | 15 | -4.2 | NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm030611c | |||
| 135520200 | 160556 | 0 | None | None | None | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 522 | 9 | 3 | 7 | 2.4 | CCOc1ccc(S(=O)(=O)N(c2ccc(C)cc2)C(CO)C(=O)N/N=C2\C(=O)Nc3ccccc32)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113197 | 160556 | 0 | None | None | None | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 522 | 9 | 3 | 7 | 2.4 | CCOc1ccc(S(=O)(=O)N(c2ccc(C)cc2)C(CO)C(=O)N/N=C2\C(=O)Nc3ccccc32)cc1 | 10.1021/jm050645f | |||
| 10698572 | 468794 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 586 | 7 | 0 | 7 | 4.4 | COc1cc(OC2CCN(Cc3ccc(C)[n+]([O-])c3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL68373 | 468794 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 586 | 7 | 0 | 7 | 4.4 | COc1cc(OC2CCN(Cc3ccc(C)[n+]([O-])c3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 10746141 | 468478 | 0 | None | -2 | 2 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 600 | 6 | 0 | 7 | 4.1 | COc1cc(OC2CCN(C(=O)c3ccc[n+]([O-])c3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL65950 | 468478 | 0 | None | -2 | 2 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 600 | 6 | 0 | 7 | 4.1 | COc1cc(OC2CCN(C(=O)c3ccc[n+]([O-])c3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 1103817 | 40884 | 7 | None | -3 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 492 | 8 | 2 | 6 | 3.1 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(C)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL1254117 | 40884 | 7 | None | -3 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 492 | 8 | 2 | 6 | 3.1 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(C)cc2)cc1 | 10.1021/jm050645f | |||
| 1103817 | 40884 | 7 | None | -3 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 492 | 8 | 2 | 6 | 3.1 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(C)cc2)cc1 | 10.1021/jm901812z | |||
| CHEMBL1254117 | 40884 | 7 | None | -3 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 492 | 8 | 2 | 6 | 3.1 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(C)cc2)cc1 | 10.1021/jm901812z | |||
| 2253 | 4548 | 22 | None | -19 | 6 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 586 | 7 | 0 | 7 | 4.4 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)Cc1ccc[n+](c1C)[O-] | 10.1021/jm901812z | |||
| 5311202 | 4548 | 22 | None | -19 | 6 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 586 | 7 | 0 | 7 | 4.4 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)Cc1ccc[n+](c1C)[O-] | 10.1021/jm901812z | |||
| CHEMBL306645 | 4548 | 22 | None | -19 | 6 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 586 | 7 | 0 | 7 | 4.4 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)Cc1ccc[n+](c1C)[O-] | 10.1021/jm901812z | |||
| 135530164 | 160558 | 0 | None | -1 | 3 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 570 | 11 | 2 | 8 | 2.7 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccncc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113200 | 160558 | 0 | None | -1 | 3 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 570 | 11 | 2 | 8 | 2.7 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccncc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL297725 | 486403 | 0 | None | 31 | 2 | Rat | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 726 | 6 | 3 | 6 | 2.7 | CC[C@H](C)[C@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00169a001 | |||
| CHEMBL52813 | 489209 | 0 | None | 23 | 2 | Rat | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 712 | 6 | 2 | 6 | 2.3 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCN2C1=O | 10.1021/jm00169a001 | |||
| 53321821 | 119142 | 0 | None | None | None | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 975 | 10 | 11 | 14 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](C(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N2 | 10.1021/jm100989w | |||
| CHEMBL1630532 | 119142 | 0 | None | None | None | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 975 | 10 | 11 | 14 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](C(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N2 | 10.1021/jm100989w | |||
| 135413563 | 241495 | 20 | None | 1 | 8 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 600 | 4 | 2 | 7 | 4.3 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1 | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL360648 | 241495 | 20 | None | 1 | 8 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 600 | 4 | 2 | 7 | 4.3 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1 | 10.1021/acs.jmedchem.8b00697 | |||
| 145960494 | 317101 | 0 | None | 13 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1081 | 17 | 11 | 14 | -0.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2ccc(cc2)SC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2018.03.019 | |||
| CHEMBL4128839 | 317101 | 0 | None | 13 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 1081 | 17 | 11 | 14 | -0.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2ccc(cc2)SC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2018.03.019 | |||
| CHEMBL2369837 | 477597 | 0 | None | -794 | 4 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 1068 | 20 | 13 | 15 | -3.5 | NCCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| CHEMBL2369830 | 477592 | 0 | None | -338 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 1053 | 19 | 12 | 14 | -2.4 | CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| CHEMBL429161 | 488539 | 0 | None | None | None | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 1062 | 17 | 12 | 15 | -2.2 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](N)CSSC[C@@H](C(=O)N2[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)CC[C@@H]2C(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm990090m | |||
| 44419028 | 197233 | 21 | None | -1202 | 8 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 1093 | 18 | 12 | 14 | -1.6 | NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm060928n | |||
| CHEMBL265858 | 197233 | 21 | None | -1202 | 8 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 1093 | 18 | 12 | 14 | -1.6 | NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm060928n | |||
| 135413563 | 241495 | 20 | None | 1 | 8 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 600 | 4 | 2 | 7 | 4.3 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1 | 10.1021/jm901084f | |||
| CHEMBL360648 | 241495 | 20 | None | 1 | 8 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 600 | 4 | 2 | 7 | 4.3 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1 | 10.1021/jm901084f | |||
| 44335268 | 19240 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 410 | 5 | 0 | 5 | 3.9 | CCOc1ccc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)c(OC)c1 | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL104530 | 19240 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 410 | 5 | 0 | 5 | 3.9 | CCOc1ccc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)c(OC)c1 | 10.1016/s0960-894x(98)00568-x | |||
| 2253 | 4548 | 22 | None | -19 | 6 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 586 | 7 | 0 | 7 | 4.4 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)Cc1ccc[n+](c1C)[O-] | 10.1021/jm9800797 | |||
| 5311202 | 4548 | 22 | None | -19 | 6 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 586 | 7 | 0 | 7 | 4.4 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)Cc1ccc[n+](c1C)[O-] | 10.1021/jm9800797 | |||
| CHEMBL306645 | 4548 | 22 | None | -19 | 6 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 586 | 7 | 0 | 7 | 4.4 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)Cc1ccc[n+](c1C)[O-] | 10.1021/jm9800797 | |||
| 73350823 | 202597 | 0 | None | 5 | 9 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 509 | 8 | 1 | 5 | 3.7 | O=C(Cc1ccc(OC2CCNCC2)cc1OCCF)N1CCC(N2C(=O)CCc3ccccc32)CC1 | 10.1016/j.bmcl.2013.07.045 | |||
| CHEMBL3040578 | 202597 | 0 | None | 5 | 9 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 509 | 8 | 1 | 5 | 3.7 | O=C(Cc1ccc(OC2CCNCC2)cc1OCCF)N1CCC(N2C(=O)CCc3ccccc32)CC1 | 10.1016/j.bmcl.2013.07.045 | |||
| 135438560 | 272650 | 0 | None | 42 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 487 | 9 | 2 | 6 | 3.8 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C/c2ccccc2O)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL372122 | 272650 | 0 | None | 42 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 487 | 9 | 2 | 6 | 3.8 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C/c2ccccc2O)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| 135469700 | 160561 | 0 | None | -7 | 3 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 555 | 10 | 2 | 7 | 2.9 | CN(C)CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113203 | 160561 | 0 | None | -7 | 3 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 555 | 10 | 2 | 7 | 2.9 | CN(C)CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| 135438560 | 272650 | 0 | None | 42 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 487 | 9 | 2 | 6 | 3.8 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C/c2ccccc2O)c2ccc(Cl)cc2)cc1 | 10.1039/C5MD00566C | |||
| CHEMBL372122 | 272650 | 0 | None | 42 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 487 | 9 | 2 | 6 | 3.8 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C/c2ccccc2O)c2ccc(Cl)cc2)cc1 | 10.1039/C5MD00566C | |||
| 44279692 | 199860 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 504 | 6 | 2 | 6 | 2.9 | CC(=O)NCC(=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL284419 | 199860 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 504 | 6 | 2 | 6 | 2.9 | CC(=O)NCC(=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00159-2 | |||
| 44279390 | 199896 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 573 | 6 | 2 | 7 | 3.1 | CC1(C)NC(=O)N(CC(=O)NCc2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)C1=O | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL284688 | 199896 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 573 | 6 | 2 | 7 | 3.1 | CC1(C)NC(=O)N(CC(=O)NCc2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)C1=O | 10.1016/s0960-894x(02)00159-2 | |||
| 56950451 | 156712 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 489 | 8 | 2 | 3 | 4.0 | CCc1ccccc1[C@H](C(=O)NC(C)C)N1C(=O)[C@@H](C2Cc3ccccc3C2)NC(=O)[C@H]1CC(C)C | 10.1021/jm201287w | |||
| CHEMBL2035011 | 156712 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 489 | 8 | 2 | 3 | 4.0 | CCc1ccccc1[C@H](C(=O)NC(C)C)N1C(=O)[C@@H](C2Cc3ccccc3C2)NC(=O)[C@H]1CC(C)C | 10.1021/jm201287w | |||
| 10031014 | 194267 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 574 | 11 | 2 | 5 | 4.6 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)NCCc2cccc3ccccc23)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL24786 | 194267 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 574 | 11 | 2 | 5 | 4.6 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)NCCc2cccc3ccccc23)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| 11757835 | 199981 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 574 | 11 | 2 | 5 | 4.6 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)NCCc2ccc3ccccc3c2)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL285312 | 199981 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 574 | 11 | 2 | 5 | 4.6 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)NCCc2ccc3ccccc3c2)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL1790549 | 484808 | 0 | None | 18 | 2 | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 758 | 6 | 4 | 9 | 1.4 | CC[C@@H](C)[C@H]1C(=O)N2NCCC[C@@H]2C(=O)N2NCCC[C@H]2C(=O)N(C)[C@H](Cc2ccccc2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)N1O | 10.1021/jm00171a003 | |||
| 44361387 | 238172 | 0 | None | -10 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 505 | 6 | 0 | 5 | 4.6 | CC(=O)N1CCCCC1CCOc1ccc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)cc1 | 10.1021/jm00023a002 | |||
| CHEMBL344752 | 238172 | 0 | None | -10 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 505 | 6 | 0 | 5 | 4.6 | CC(=O)N1CCCCC1CCOc1ccc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)cc1 | 10.1021/jm00023a002 | |||
| 145975166 | 328759 | 0 | None | -2 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 328 | 2 | 0 | 2 | 4.7 | O=C(c1ccc(-c2cccnc2)cc1)N1CCCCc2ccccc21 | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL4205970 | 328759 | 0 | None | -2 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 328 | 2 | 0 | 2 | 4.7 | O=C(c1ccc(-c2cccnc2)cc1)N1CCCCc2ccccc21 | 10.1021/acs.jmedchem.8b00697 | |||
| 73346892 | 180193 | 0 | None | None | None | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 975 | 17 | 12 | 14 | -3.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| CHEMBL2369424 | 180193 | 0 | None | None | None | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 975 | 17 | 12 | 14 | -3.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| 44279433 | 199938 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 524 | 7 | 0 | 6 | 3.7 | CN(CCCn1ccc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc21)S(C)(=O)=O | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL285012 | 199938 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 524 | 7 | 0 | 6 | 3.7 | CN(CCCn1ccc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc21)S(C)(=O)=O | 10.1016/s0960-894x(02)00159-2 | |||
| 44279772 | 200144 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 500 | 4 | 0 | 5 | 4.4 | CC(=O)N1CCC[C@@H]1Cn1ccc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc21 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL286476 | 200144 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 500 | 4 | 0 | 5 | 4.4 | CC(=O)N1CCC[C@@H]1Cn1ccc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc21 | 10.1016/s0960-894x(02)00159-2 | |||
| 44279000 | 216853 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 434 | 3 | 0 | 6 | 4.3 | Cc1nc(-c2cccs2)ncc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL31665 | 216853 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 434 | 3 | 0 | 6 | 4.3 | Cc1nc(-c2cccs2)ncc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| 70694330 | 156717 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 519 | 8 | 2 | 5 | 3.2 | COC(=O)c1ccccc1[C@@H](C(=O)NC(C)C)N1C(=O)[C@@H](C2Cc3ccccc3C2)NC(=O)[C@H]1CC(C)C | 10.1021/jm201287w | |||
| CHEMBL2035016 | 156717 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 519 | 8 | 2 | 5 | 3.2 | COC(=O)c1ccccc1[C@@H](C(=O)NC(C)C)N1C(=O)[C@@H](C2Cc3ccccc3C2)NC(=O)[C@H]1CC(C)C | 10.1021/jm201287w | |||
| 44404013 | 143997 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 504 | 8 | 3 | 4 | 2.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccc(C(N)=O)cc1 | 10.1021/jm050557v | |||
| 44404031 | 143997 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 504 | 8 | 3 | 4 | 2.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccc(C(N)=O)cc1 | 10.1021/jm050557v | |||
| CHEMBL196688 | 143997 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 504 | 8 | 3 | 4 | 2.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccc(C(N)=O)cc1 | 10.1021/jm050557v | |||
| CHEMBL197298 | 143997 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 504 | 8 | 3 | 4 | 2.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccc(C(N)=O)cc1 | 10.1021/jm050557v | |||
| 11577662 | 144024 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 559 | 7 | 2 | 4 | 4.7 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccc(OC(F)(F)F)cc1 | 10.1021/jm050557v | |||
| 11606502 | 144024 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 559 | 7 | 2 | 4 | 4.7 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccc(OC(F)(F)F)cc1 | 10.1021/jm050557v | |||
| CHEMBL196780 | 144024 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 559 | 7 | 2 | 4 | 4.7 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccc(OC(F)(F)F)cc1 | 10.1021/jm050557v | |||
| CHEMBL372516 | 144024 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 559 | 7 | 2 | 4 | 4.7 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccc(OC(F)(F)F)cc1 | 10.1021/jm050557v | |||
| 11677875 | 144698 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 509 | 6 | 2 | 3 | 4.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)(C)C)c1ccc(Cl)cc1 | 10.1021/jm050557v | |||
| 11706166 | 144698 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 509 | 6 | 2 | 3 | 4.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)(C)C)c1ccc(Cl)cc1 | 10.1021/jm050557v | |||
| CHEMBL198964 | 144698 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 509 | 6 | 2 | 3 | 4.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)(C)C)c1ccc(Cl)cc1 | 10.1021/jm050557v | |||
| CHEMBL381024 | 144698 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 509 | 6 | 2 | 3 | 4.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)(C)C)c1ccc(Cl)cc1 | 10.1021/jm050557v | |||
| 11534310 | 272633 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 573 | 7 | 2 | 5 | 3.6 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1cccc(N2CCN(C)CC2)c1 | 10.1021/jm050557v | |||
| CHEMBL371983 | 272633 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 573 | 7 | 2 | 5 | 3.6 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1cccc(N2CCN(C)CC2)c1 | 10.1021/jm050557v | |||
| 44274970 | 331744 | 0 | None | None | None | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 502 | 7 | 1 | 4 | 3.7 | CC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N(C)CCc2cccc(Cl)c2)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL428694 | 331744 | 0 | None | None | None | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 502 | 7 | 1 | 4 | 3.7 | CC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N(C)CCc2cccc(Cl)c2)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| 10650710 | 468577 | 0 | None | 3 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 570 | 7 | 0 | 7 | 5.5 | COc1cc(OC2CCN(C(C)c3cccnc3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL66749 | 468577 | 0 | None | 3 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 570 | 7 | 0 | 7 | 5.5 | COc1cc(OC2CCN(C(C)c3cccnc3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 10675477 | 197143 | 0 | None | -6 | 2 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 630 | 6 | 0 | 7 | 5.2 | COc1cc(OC2CCN([C@@H]3CCCc4c3ccc[n+]4[O-])CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL265070 | 197143 | 0 | None | -6 | 2 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 630 | 6 | 0 | 7 | 5.2 | COc1cc(OC2CCN([C@@H]3CCCc4c3ccc[n+]4[O-])CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 10699323 | 468907 | 0 | None | -2 | 2 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 640 | 7 | 0 | 7 | 5.2 | COc1cc(OC2CCN(Cc3c[n+]([O-])ccc3C(F)(F)F)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL69265 | 468907 | 0 | None | -2 | 2 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 640 | 7 | 0 | 7 | 5.2 | COc1cc(OC2CCN(Cc3c[n+]([O-])ccc3C(F)(F)F)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 57519948 | 155341 | 4 | None | 112 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 587 | 9 | 0 | 6 | 3.4 | CS(=O)(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)CCc5ccccc54)CC3)c(OCCF)c2)CC1 | 10.1016/j.bmcl.2013.07.045 | |||
| CHEMBL2017869 | 155341 | 4 | None | 112 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 587 | 9 | 0 | 6 | 3.4 | CS(=O)(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)CCc5ccccc54)CC3)c(OCCF)c2)CC1 | 10.1016/j.bmcl.2013.07.045 | |||
| 57519948 | 155341 | 4 | None | 112 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 587 | 9 | 0 | 6 | 3.4 | CS(=O)(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)CCc5ccccc54)CC3)c(OCCF)c2)CC1 | 10.1016/j.bmc.2016.10.035 | |||
| CHEMBL2017869 | 155341 | 4 | None | 112 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 587 | 9 | 0 | 6 | 3.4 | CS(=O)(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)CCc5ccccc54)CC3)c(OCCF)c2)CC1 | 10.1016/j.bmc.2016.10.035 | |||
| 57519948 | 155341 | 4 | None | 112 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 587 | 9 | 0 | 6 | 3.4 | CS(=O)(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)CCc5ccccc54)CC3)c(OCCF)c2)CC1 | 10.1016/j.bmc.2012.02.019 | |||
| CHEMBL2017869 | 155341 | 4 | None | 112 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 587 | 9 | 0 | 6 | 3.4 | CS(=O)(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)CCc5ccccc54)CC3)c(OCCF)c2)CC1 | 10.1016/j.bmc.2012.02.019 | |||
| 155753110 | 392355 | 5 | None | -53 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 452 | 3 | 0 | 7 | 4.3 | Clc1ccc2c(c1)CC1(Cc3nnc([C@H]4CC[C@H](Oc5ccccn5)CC4)n3-2)OCCO1 | 10.1021/acs.jmedchem.3c01868 | |||
| CHEMBL5594994 | 392355 | 5 | None | -53 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 452 | 3 | 0 | 7 | 4.3 | Clc1ccc2c(c1)CC1(Cc3nnc([C@H]4CC[C@H](Oc5ccccn5)CC4)n3-2)OCCO1 | 10.1021/acs.jmedchem.3c01868 | |||
| 44334980 | 19463 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 487 | 6 | 0 | 6 | 5.0 | COc1cc(O[C@@H](C)c2ccncc2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL105673 | 19463 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 487 | 6 | 0 | 6 | 5.0 | COc1cc(O[C@@H](C)c2ccncc2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| 1153925 | 144078 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 448 | 6 | 1 | 3 | 5.1 | Cc1c(Cl)cccc1NC(=O)CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccccc1 | 10.1021/jm050645f | |||
| CHEMBL196974 | 144078 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 448 | 6 | 1 | 3 | 5.1 | Cc1c(Cl)cccc1NC(=O)CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccccc1 | 10.1021/jm050645f | |||
| 1135733 | 273445 | 9 | None | -1 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 436 | 6 | 0 | 4 | 3.5 | COc1ccc(N(CC(=O)N2CCc3ccccc3C2)S(=O)(=O)c2ccccc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL373167 | 273445 | 9 | None | -1 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 436 | 6 | 0 | 4 | 3.5 | COc1ccc(N(CC(=O)N2CCc3ccccc3C2)S(=O)(=O)c2ccccc2)cc1 | 10.1021/jm050645f | |||
| 44275210 | 195410 | 0 | None | -4 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 491 | 5 | 0 | 5 | 3.8 | CC(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc2)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL25502 | 195410 | 0 | None | -4 | 2 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 491 | 5 | 0 | 5 | 3.8 | CC(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc2)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| 9797987 | 237306 | 1 | None | -1 | 3 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 339 | 2 | 0 | 2 | 3.7 | Cc1ccc(S(=O)(=O)N2CCC3(C=Cc4ccccc43)CC2)cc1 | 10.1021/jm901812z | |||
| CHEMBL341490 | 237306 | 1 | None | -1 | 3 | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 339 | 2 | 0 | 2 | 3.7 | Cc1ccc(S(=O)(=O)N2CCC3(C=Cc4ccccc43)CC2)cc1 | 10.1021/jm901812z | |||
| CHEMBL2369847 | 477604 | 0 | None | -16 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 1087 | 18 | 12 | 14 | -2.4 | NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm030611c | |||
| 145961670 | 316908 | 0 | None | -5 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 1139 | 19 | 14 | 15 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2ccccc2CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2018.03.019 | |||
| CHEMBL4126100 | 316908 | 0 | None | -5 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 1139 | 19 | 14 | 15 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2ccccc2CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2018.03.019 | |||
| 44334970 | 19345 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 424 | 5 | 0 | 5 | 4.2 | COc1cc(OC(C)C)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL105039 | 19345 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 424 | 5 | 0 | 5 | 4.2 | COc1cc(OC(C)C)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL1790937 | 484815 | 0 | None | -2 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 755 | 6 | 5 | 7 | 1.9 | CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 135916070 | 450839 | 0 | None | 1 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 418 | 2 | 1 | 6 | 4.5 | Cc1ccn(-c2ccc(C(=O)N3Cc4cnn(C)c4Nc4ccccc43)c(Cl)c2)n1 | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL601931 | 450839 | 0 | None | 1 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 418 | 2 | 1 | 6 | 4.5 | Cc1ccn(-c2ccc(C(=O)N3Cc4cnn(C)c4Nc4ccccc43)c(Cl)c2)n1 | 10.1021/acs.jmedchem.8b00697 | |||
| 135916070 | 450839 | 0 | None | 1 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 418 | 2 | 1 | 6 | 4.5 | Cc1ccn(-c2ccc(C(=O)N3Cc4cnn(C)c4Nc4ccccc43)c(Cl)c2)n1 | 10.1021/jm901084f | |||
| CHEMBL601931 | 450839 | 0 | None | 1 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 418 | 2 | 1 | 6 | 4.5 | Cc1ccn(-c2ccc(C(=O)N3Cc4cnn(C)c4Nc4ccccc43)c(Cl)c2)n1 | 10.1021/jm901084f | |||
| 21476314 | 232095 | 3 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 554 | 9 | 2 | 7 | 1.5 | Cc1ccccc1N1CCN(S(=O)(=O)CC23CCC(CC2NC(=O)C(N)CCS(C)(=O)=O)C3(C)C)CC1 | 10.1016/j.bmc.2016.10.035 | |||
| CHEMBL3392901 | 232095 | 3 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 554 | 9 | 2 | 7 | 1.5 | Cc1ccccc1N1CCN(S(=O)(=O)CC23CCC(CC2NC(=O)C(N)CCS(C)(=O)=O)C3(C)C)CC1 | 10.1016/j.bmc.2016.10.035 | |||
| 54581530 | 125120 | 0 | None | -562 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 666 | 9 | 0 | 8 | 4.5 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3cc(CN4CCCC4)ccc3OC)(N3CCC[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)cc1 | 10.1016/j.bmcl.2011.03.012 | |||
| CHEMBL1779409 | 125120 | 0 | None | -562 | 3 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 666 | 9 | 0 | 8 | 4.5 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3cc(CN4CCCC4)ccc3OC)(N3CCC[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)cc1 | 10.1016/j.bmcl.2011.03.012 | |||
| CHEMBL292579 | 486388 | 0 | None | 32 | 2 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 744 | 9 | 5 | 8 | 0.7 | CC[C@@H](C)[C@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCN)NC(=O)[C@H]2CCNCN2C1=O | 10.1021/jm00169a001 | |||
| 135475778 | 160568 | 0 | None | 223 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 540 | 10 | 2 | 6 | 4.2 | CCCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1039/C5MD00566C | |||
| CHEMBL2113210 | 160568 | 0 | None | 223 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 540 | 10 | 2 | 6 | 4.2 | CCCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1039/C5MD00566C | |||
| CHEMBL2372252 | 477728 | 0 | None | None | None | Rat | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 1062 | 17 | 11 | 14 | -0.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(C)(C)SS[C@@H](C(=O)N2C(C(C)(C)C)CC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm990090m | |||
| 114904 | 6013 | 43 | None | -5 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 449 | 7 | 1 | 4 | 3.2 | CC(=O)NCCCOc1ccc(cc1)C(=O)N1CCC(CC1)N1C(=O)CCc2c1cccc2 | 10.1021/jm00023a002 | |||
| 2196 | 6013 | 43 | None | -5 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 449 | 7 | 1 | 4 | 3.2 | CC(=O)NCCCOc1ccc(cc1)C(=O)N1CCC(CC1)N1C(=O)CCc2c1cccc2 | 10.1021/jm00023a002 | |||
| CHEMBL296908 | 6013 | 43 | None | -5 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 449 | 7 | 1 | 4 | 3.2 | CC(=O)NCCCOc1ccc(cc1)C(=O)N1CCC(CC1)N1C(=O)CCc2c1cccc2 | 10.1021/jm00023a002 | |||
| 114904 | 6013 | 43 | None | -5 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 449 | 7 | 1 | 4 | 3.2 | CC(=O)NCCCOc1ccc(cc1)C(=O)N1CCC(CC1)N1C(=O)CCc2c1cccc2 | 10.1021/jm901812z | |||
| 2196 | 6013 | 43 | None | -5 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 449 | 7 | 1 | 4 | 3.2 | CC(=O)NCCCOc1ccc(cc1)C(=O)N1CCC(CC1)N1C(=O)CCc2c1cccc2 | 10.1021/jm901812z | |||
| CHEMBL296908 | 6013 | 43 | None | -5 | 5 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 449 | 7 | 1 | 4 | 3.2 | CC(=O)NCCCOc1ccc(cc1)C(=O)N1CCC(CC1)N1C(=O)CCc2c1cccc2 | 10.1021/jm901812z | |||
| 54585431 | 125126 | 0 | None | -141 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 662 | 9 | 0 | 9 | 5.8 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3cc(CN4CCCC4)ccc3OC)(N3CCC[C@H]3c3ncco3)c3cc(Cl)ccc32)cc1 | 10.1016/j.bmcl.2011.03.012 | |||
| CHEMBL1779417 | 125126 | 0 | None | -141 | 3 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 662 | 9 | 0 | 9 | 5.8 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3cc(CN4CCCC4)ccc3OC)(N3CCC[C@H]3c3ncco3)c3cc(Cl)ccc32)cc1 | 10.1016/j.bmcl.2011.03.012 | |||
| 135414270 | 160564 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 498 | 6 | 2 | 5 | 3.8 | Cc1ccc(N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)S(=O)(=O)c2cccc3ccccc23)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113206 | 160564 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 498 | 6 | 2 | 5 | 3.8 | Cc1ccc(N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)S(=O)(=O)c2cccc3ccccc23)cc1 | 10.1021/jm050645f | |||
| 135997467 | 160572 | 0 | None | None | None | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 538 | 8 | 2 | 5 | 4.7 | CCC(C)(C)c1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113214 | 160572 | 0 | None | None | None | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 538 | 8 | 2 | 5 | 4.7 | CCC(C)(C)c1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| 54585227 | 123947 | 0 | None | -104 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 1042 | 18 | 12 | 15 | -1.9 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)C(O)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm1016208 | |||
| CHEMBL1765669 | 123947 | 0 | None | -104 | 4 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 1042 | 18 | 12 | 15 | -1.9 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)C(O)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm1016208 | |||
| CHEMBL2370342 | 477651 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 1323 | 36 | 15 | 17 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CC1(SCCC(N)=O)CCCCC1)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc1ccc(N=[N+]=[N-])c(I)c1)C(N)=O)[C@@H](C)O | 10.1021/jm010125u | |||
| 135475778 | 160568 | 0 | None | 223 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 540 | 10 | 2 | 6 | 4.2 | CCCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113210 | 160568 | 0 | None | 223 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 540 | 10 | 2 | 6 | 4.2 | CCCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| 135520202 | 271064 | 0 | None | 33 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 528 | 8 | 2 | 7 | 5.1 | COc1ccc(S(=O)(=O)N(CC(=O)/N=N/c2c(O)[nH]c3ccccc23)c2ccc(Cl)cc2)cc1OC | 10.1021/jm050645f | |||
| CHEMBL371223 | 271064 | 0 | None | 33 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 528 | 8 | 2 | 7 | 5.1 | COc1ccc(S(=O)(=O)N(CC(=O)/N=N/c2c(O)[nH]c3ccccc23)c2ccc(Cl)cc2)cc1OC | 10.1021/jm050645f | |||
| 44297517 | 311660 | 0 | None | -120 | 3 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 1343 | 39 | 15 | 16 | -1.4 | CN(C(=O)CCCc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | 10.1021/jm00038a013 | |||
| CHEMBL405440 | 311660 | 0 | None | -120 | 3 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 1343 | 39 | 15 | 16 | -1.4 | CN(C(=O)CCCc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | 10.1021/jm00038a013 | |||
| 19690978 | 219100 | 0 | None | None | None | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 548 | 7 | 0 | 5 | 6.6 | COc1cc(OC(c2ccccc2)c2ccccc2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL322162 | 219100 | 0 | None | None | None | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 548 | 7 | 0 | 5 | 6.6 | COc1cc(OC(c2ccccc2)c2ccccc2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| 71457081 | 163802 | 0 | None | -31 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1309 | 24 | 5 | 14 | 10.2 | CCN1/C(=C/C=C/C=C/C2=[N+](CC)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)C(C)(CCCC(=O)NCCn2cc(CNC(=O)CCC(=O)NC3CCCN(C(=O)c4ccc(NC(=O)c5ccccc5-c5ccccc5)cc4)c4ccccc43)nn2)c2cc(S(=O)(=O)O)ccc21 | 10.1021/jm3006146 | |||
| 71482251 | 163802 | 0 | None | -31 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1309 | 24 | 5 | 14 | 10.2 | CCN1/C(=C/C=C/C=C/C2=[N+](CC)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)C(C)(CCCC(=O)NCCn2cc(CNC(=O)CCC(=O)NC3CCCN(C(=O)c4ccc(NC(=O)c5ccccc5-c5ccccc5)cc4)c4ccccc43)nn2)c2cc(S(=O)(=O)O)ccc21 | 10.1021/jm3006146 | |||
| CHEMBL2172289 | 163802 | 0 | None | -31 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1309 | 24 | 5 | 14 | 10.2 | CCN1/C(=C/C=C/C=C/C2=[N+](CC)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)C(C)(CCCC(=O)NCCn2cc(CNC(=O)CCC(=O)NC3CCCN(C(=O)c4ccc(NC(=O)c5ccccc5-c5ccccc5)cc4)c4ccccc43)nn2)c2cc(S(=O)(=O)O)ccc21 | 10.1021/jm3006146 | |||
| 2252 | 4546 | 39 | None | -5 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/s0960-894x(98)00568-x | |||
| 6918320 | 4546 | 39 | None | -5 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL24781 | 4546 | 39 | None | -5 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/s0960-894x(98)00568-x | |||
| 2252 | 4546 | 39 | None | -5 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/s0960-894x(99)00181-x | |||
| 6918320 | 4546 | 39 | None | -5 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL24781 | 4546 | 39 | None | -5 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/s0960-894x(99)00181-x | |||
| 2252 | 4546 | 39 | None | -5 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1021/jm00023a002 | |||
| 6918320 | 4546 | 39 | None | -5 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1021/jm00023a002 | |||
| CHEMBL24781 | 4546 | 39 | None | -5 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1021/jm00023a002 | |||
| 2252 | 4546 | 39 | None | -5 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1021/jm901812z | |||
| 6918320 | 4546 | 39 | None | -5 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1021/jm901812z | |||
| CHEMBL24781 | 4546 | 39 | None | -5 | 5 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1021/jm901812z | |||
| 2202 | 5638 | 34 | None | -10 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 10.1016/j.bmcl.2010.12.081 | |||
| 9895468 | 5638 | 34 | None | -10 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 10.1016/j.bmcl.2010.12.081 | |||
| CHEMBL582857 | 5638 | 34 | None | -10 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 10.1016/j.bmcl.2010.12.081 | |||
| DB12643 | 5638 | 34 | None | -10 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 10.1016/j.bmcl.2010.12.081 | |||
| 2202 | 5638 | 34 | None | -10 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 10.1016/j.bmcl.2009.09.050 | |||
| 9895468 | 5638 | 34 | None | -10 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 10.1016/j.bmcl.2009.09.050 | |||
| CHEMBL582857 | 5638 | 34 | None | -10 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 10.1016/j.bmcl.2009.09.050 | |||
| DB12643 | 5638 | 34 | None | -10 | 5 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 10.1016/j.bmcl.2009.09.050 | |||
| 44278943 | 199858 | 0 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 536 | 5 | 0 | 6 | 3.8 | CS(=O)(=O)N1CCC[C@@H]1Cn1ccc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc21 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL284410 | 199858 | 0 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 536 | 5 | 0 | 6 | 3.8 | CS(=O)(=O)N1CCC[C@@H]1Cn1ccc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc21 | 10.1016/s0960-894x(02)00159-2 | |||
| 44275099 | 199079 | 0 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 558 | 11 | 2 | 5 | 4.1 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)NCCc2cccc(Cl)c2)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL278802 | 199079 | 0 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 558 | 11 | 2 | 5 | 4.1 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)NCCc2cccc(Cl)c2)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| 16109443 | 278920 | 0 | None | -1023 | 4 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1040 | 18 | 14 | 15 | -4.0 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| CHEMBL385739 | 278920 | 0 | None | -1023 | 4 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1040 | 18 | 14 | 15 | -4.0 | N=C(N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| 3537 | 8682 | 25 | None | -3 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 402 | 2 | 0 | 4 | 4.8 | Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 | 10.1021/acs.jmedchem.8b00697 | |||
| 5311500 | 8682 | 25 | None | -3 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 402 | 2 | 0 | 4 | 4.8 | Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL363910 | 8682 | 25 | None | -3 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 402 | 2 | 0 | 4 | 4.8 | Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 | 10.1021/acs.jmedchem.8b00697 | |||
| 3537 | 8682 | 25 | None | -3 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 402 | 2 | 0 | 4 | 4.8 | Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 | 10.1021/jm901084f | |||
| 5311500 | 8682 | 25 | None | -3 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 402 | 2 | 0 | 4 | 4.8 | Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 | 10.1021/jm901084f | |||
| CHEMBL363910 | 8682 | 25 | None | -3 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 402 | 2 | 0 | 4 | 4.8 | Cc1ccn(n1)c1ccc(c(c1)Cl)C(=O)N1Cc2cccn2Cc2c1cccc2 | 10.1021/jm901084f | |||
| 44278944 | 199584 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 375 | 2 | 1 | 3 | 3.9 | O=C(c1ccc2cc[nH]c2c1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL282577 | 199584 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 375 | 2 | 1 | 3 | 3.9 | O=C(c1ccc2cc[nH]c2c1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| 44279485 | 200426 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 501 | 3 | 0 | 5 | 4.9 | CC(=O)N1CCCC(c2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)C1 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL288774 | 200426 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 501 | 3 | 0 | 5 | 4.9 | CC(=O)N1CCCC(c2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)C1 | 10.1016/s0960-894x(02)00159-2 | |||
| 44278929 | 215325 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 375 | 2 | 1 | 3 | 3.9 | O=C(c1ccc2[nH]ccc2c1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL31241 | 215325 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 375 | 2 | 1 | 3 | 3.9 | O=C(c1ccc2[nH]ccc2c1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| 44279774 | 217620 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 537 | 5 | 0 | 6 | 4.2 | CS(=O)(=O)N1CCC[C@@H]1Cc1coc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc12 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL31941 | 217620 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 537 | 5 | 0 | 6 | 4.2 | CS(=O)(=O)N1CCC[C@@H]1Cc1coc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc12 | 10.1016/s0960-894x(02)00159-2 | |||
| 44275002 | 183395 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 573 | 11 | 3 | 6 | 2.6 | CC(=O)CCCC(=O)NC1N=C(C)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL24353 | 183395 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 573 | 11 | 3 | 6 | 2.6 | CC(=O)CCCC(=O)NC1N=C(C)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| 44274927 | 194749 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 558 | 11 | 2 | 5 | 4.1 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)NCCc2ccccc2Cl)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL25067 | 194749 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 558 | 11 | 2 | 5 | 4.1 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)NCCc2ccccc2Cl)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| 10074886 | 19180 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 505 | 6 | 0 | 6 | 5.1 | COc1cc(O[C@H](C)c2ccncc2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL104237 | 19180 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 505 | 6 | 0 | 6 | 5.1 | COc1cc(O[C@H](C)c2ccncc2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| 44214438 | 461726 | 0 | None | 3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 630 | 6 | 0 | 7 | 5.2 | COc1cc(OC2CCN(C3CCCc4c3ccc[n+]4[O-])CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL66992 | 461726 | 0 | None | 3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 630 | 6 | 0 | 7 | 5.2 | COc1cc(OC2CCN(C3CCCc4c3ccc[n+]4[O-])CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 10416272 | 214451 | 4 | None | 630 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 608 | 6 | 1 | 7 | 4.7 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1021/jm901812z | |||
| CHEMBL31065 | 214451 | 4 | None | 630 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 608 | 6 | 1 | 7 | 4.7 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1021/jm901812z | |||
| 10416272 | 214451 | 4 | None | 630 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 608 | 6 | 1 | 7 | 4.7 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1021/jm901812z | |||
| CHEMBL31065 | 214451 | 4 | None | 630 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 608 | 6 | 1 | 7 | 4.7 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1021/jm901812z | |||
| 146681949 | 8624 | 35 | None | -5 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/acs.jmedchem.8b01691 | |||
| 2168 | 8624 | 35 | None | -5 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/acs.jmedchem.8b01691 | |||
| 2810 | 8624 | 35 | None | -5 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/acs.jmedchem.8b01691 | |||
| 644077 | 8624 | 35 | None | -5 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/acs.jmedchem.8b01691 | |||
| CHEMBL373742 | 8624 | 35 | None | -5 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/acs.jmedchem.8b01691 | |||
| DB00067 | 8624 | 35 | None | -5 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/acs.jmedchem.8b01691 | |||
| P01185 | 8624 | 35 | None | -5 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/acs.jmedchem.8b01691 | |||
| P01186 | 8624 | 35 | None | -5 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/acs.jmedchem.8b01691 | |||
| P35455 | 8624 | 35 | None | -5 | 8 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1021/acs.jmedchem.8b01691 | |||
| 135469700 | 160561 | 0 | None | 7 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 555 | 10 | 2 | 7 | 2.9 | CN(C)CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1039/C5MD00566C | |||
| CHEMBL2113203 | 160561 | 0 | None | 7 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 555 | 10 | 2 | 7 | 2.9 | CN(C)CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1039/C5MD00566C | |||
| 10507800 | 468517 | 0 | None | 5 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 600 | 8 | 0 | 7 | 4.7 | CCc1c(CN2CCC(Oc3ccc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)c(OC)c3)CC2)ccc[n+]1[O-] | 10.1021/jm9800797 | |||
| CHEMBL66240 | 468517 | 0 | None | 5 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 600 | 8 | 0 | 7 | 4.7 | CCc1c(CN2CCC(Oc3ccc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)c(OC)c3)CC2)ccc[n+]1[O-] | 10.1021/jm9800797 | |||
| 18700187 | 199084 | 0 | None | -1 | 2 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 577 | 9 | 0 | 7 | 4.0 | O=C(Cc1ccc(OCCN2CCOCC2)cc1OCC(F)(F)F)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL278818 | 199084 | 0 | None | -1 | 2 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 577 | 9 | 0 | 7 | 4.0 | O=C(Cc1ccc(OCCN2CCOCC2)cc1OCC(F)(F)F)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| 135469700 | 160561 | 0 | None | 7 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 555 | 10 | 2 | 7 | 2.9 | CN(C)CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113203 | 160561 | 0 | None | 7 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 555 | 10 | 2 | 7 | 2.9 | CN(C)CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| 10675477 | 197143 | 0 | None | 6 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 630 | 6 | 0 | 7 | 5.2 | COc1cc(OC2CCN([C@@H]3CCCc4c3ccc[n+]4[O-])CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL265070 | 197143 | 0 | None | 6 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 630 | 6 | 0 | 7 | 5.2 | COc1cc(OC2CCN([C@@H]3CCCc4c3ccc[n+]4[O-])CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 10746298 | 202175 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 610 | 6 | 0 | 7 | 6.2 | COc1cc(OC2CCN(c3cccc4ncccc34)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL302128 | 202175 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 610 | 6 | 0 | 7 | 6.2 | COc1cc(OC2CCN(c3cccc4ncccc34)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL2370343 | 477652 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1337 | 37 | 14 | 17 | -0.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)CC1(SCCC(N)=O)CCCCC1)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](Cc1ccc(N=[N+]=[N-])c(I)c1)C(N)=O)[C@@H](C)O | 10.1021/jm010125u | |||
| CHEMBL2112248 | 485096 | 0 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 754 | 6 | 5 | 8 | 1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCC=NN2C1=O | 10.1021/jm00099a019 | |||
| 18700090 | 194068 | 0 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 575 | 6 | 0 | 6 | 4.7 | CC(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)c(OC(F)(F)F)c2)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL24682 | 194068 | 0 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 575 | 6 | 0 | 6 | 4.7 | CC(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)c(OC(F)(F)F)c2)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| 10722476 | 202160 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 614 | 6 | 0 | 7 | 5.9 | COc1cc(OC2CCN(C3CCCc4ncccc43)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL302029 | 202160 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 614 | 6 | 0 | 7 | 5.9 | COc1cc(OC2CCN(C3CCCc4ncccc43)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 10603831 | 468902 | 0 | None | 3 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 614 | 9 | 0 | 7 | 5.1 | CCCc1c(CN2CCC(Oc3ccc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)c(OC)c3)CC2)ccc[n+]1[O-] | 10.1021/jm9800797 | |||
| CHEMBL69202 | 468902 | 0 | None | 3 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 614 | 9 | 0 | 7 | 5.1 | CCCc1c(CN2CCC(Oc3ccc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)c(OC)c3)CC2)ccc[n+]1[O-] | 10.1021/jm9800797 | |||
| 44456469 | 315068 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 544 | 8 | 2 | 5 | 4.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(-c2ccccn2)s1 | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL409878 | 315068 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 544 | 8 | 2 | 5 | 4.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(-c2ccccn2)s1 | 10.1016/j.bmcl.2007.11.008 | |||
| 44581268 | 348947 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 505 | 9 | 0 | 7 | 4.9 | COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3C)cn2)c2ccc(OC)nc2)c(OC)c1 | 10.1016/j.bmcl.2008.11.018 | |||
| CHEMBL456464 | 348947 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 505 | 9 | 0 | 7 | 4.9 | COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3C)cn2)c2ccc(OC)nc2)c(OC)c1 | 10.1016/j.bmcl.2008.11.018 | |||
| 44279910 | 199389 | 0 | None | 630 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 570 | 7 | 1 | 8 | 3.7 | COc1cccn(CC(=O)NCc2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)c1=O | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL281243 | 199389 | 0 | None | 630 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 570 | 7 | 1 | 8 | 3.7 | COc1cccn(CC(=O)NCc2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)c1=O | 10.1016/s0960-894x(02)00160-9 | |||
| 11591519 | 144344 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 505 | 7 | 2 | 4 | 3.8 | COc1ccc([C@@H](C(=O)NC(C)(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| 11649100 | 144344 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 505 | 7 | 2 | 4 | 3.8 | COc1ccc([C@@H](C(=O)NC(C)(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| CHEMBL197822 | 144344 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 505 | 7 | 2 | 4 | 3.8 | COc1ccc([C@@H](C(=O)NC(C)(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| CHEMBL372128 | 144344 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 505 | 7 | 2 | 4 | 3.8 | COc1ccc([C@@H](C(=O)NC(C)(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| 11677875 | 144698 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 509 | 6 | 2 | 3 | 4.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)(C)C)c1ccc(Cl)cc1 | 10.1021/jm050557v | |||
| 11706166 | 144698 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 509 | 6 | 2 | 3 | 4.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)(C)C)c1ccc(Cl)cc1 | 10.1021/jm050557v | |||
| CHEMBL198964 | 144698 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 509 | 6 | 2 | 3 | 4.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)(C)C)c1ccc(Cl)cc1 | 10.1021/jm050557v | |||
| CHEMBL381024 | 144698 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 509 | 6 | 2 | 3 | 4.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)(C)C)c1ccc(Cl)cc1 | 10.1021/jm050557v | |||
| 135399831 | 160552 | 0 | None | -1 | 3 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 597 | 11 | 2 | 8 | 2.7 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)NC(=O)c3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113189 | 160552 | 0 | None | -1 | 3 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 597 | 11 | 2 | 8 | 2.7 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)NC(=O)c3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| 44275104 | 197597 | 0 | None | -33 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1127 | 32 | 14 | 14 | -3.9 | CN(C(=O)Cc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(N)=O | 10.1021/jm9804782 | |||
| CHEMBL269012 | 197597 | 0 | None | -33 | 4 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1127 | 32 | 14 | 14 | -3.9 | CN(C(=O)Cc1ccc(O)cc1)[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(N)=O | 10.1021/jm9804782 | |||
| 18700090 | 194068 | 0 | None | -1 | 2 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 575 | 6 | 0 | 6 | 4.7 | CC(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)c(OC(F)(F)F)c2)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL24682 | 194068 | 0 | None | -1 | 2 | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 575 | 6 | 0 | 6 | 4.7 | CC(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)c(OC(F)(F)F)c2)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| 10579644 | 468901 | 0 | None | -2 | 2 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 612 | 6 | 0 | 7 | 5.0 | COc1cc(OC2CCN(C3CCCc4c3ccc[n+]4[O-])CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL69201 | 468901 | 0 | None | -2 | 2 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 612 | 6 | 0 | 7 | 5.0 | COc1cc(OC2CCN(C3CCCc4c3ccc[n+]4[O-])CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 135446053 | 160573 | 0 | None | 21 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 478 | 7 | 2 | 6 | 2.7 | COc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(C)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113215 | 160573 | 0 | None | 21 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 478 | 7 | 2 | 6 | 2.7 | COc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(C)cc2)cc1 | 10.1021/jm050645f | |||
| 54580516 | 125121 | 0 | None | -660 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 695 | 9 | 0 | 9 | 3.6 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3cc(CN4CCN(C)CC4)ccc3OC)(N3CCC[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)cc1 | 10.1016/j.bmcl.2011.03.012 | |||
| CHEMBL1779410 | 125121 | 0 | None | -660 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 695 | 9 | 0 | 9 | 3.6 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3cc(CN4CCN(C)CC4)ccc3OC)(N3CCC[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)cc1 | 10.1016/j.bmcl.2011.03.012 | |||
| 44361406 | 78503 | 0 | None | -6 | 5 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 451 | 7 | 1 | 5 | 3.4 | CC(=O)NCCCOc1ccc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)cc1 | 10.1021/jm00023a002 | |||
| CHEMBL143304 | 78503 | 0 | None | -6 | 5 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 451 | 7 | 1 | 5 | 3.4 | CC(=O)NCCCOc1ccc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)cc1 | 10.1021/jm00023a002 | |||
| 44361403 | 67461 | 1 | None | -8 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 491 | 5 | 0 | 5 | 4.1 | CC(=O)N1CCCC(COc2ccc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc2)C1 | 10.1021/jm00023a002 | |||
| CHEMBL142324 | 67461 | 1 | None | -8 | 5 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 491 | 5 | 0 | 5 | 4.1 | CC(=O)N1CCCC(COc2ccc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc2)C1 | 10.1021/jm00023a002 | |||
| CHEMBL2369838 | 477598 | 0 | None | -102 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1027 | 17 | 13 | 15 | -4.6 | NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm030611c | |||
| CHEMBL338308 | 487001 | 0 | None | -4 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 742 | 9 | 4 | 8 | 1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCN)NC(=O)[C@H]2CCC=NN2C1=O | 10.1021/jm00099a019 | |||
| 135461099 | 160574 | 0 | None | 177 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 506 | 9 | 2 | 6 | 3.5 | CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(C)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113216 | 160574 | 0 | None | 177 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 506 | 9 | 2 | 6 | 3.5 | CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(C)cc2)cc1 | 10.1021/jm050645f | |||
| 54584266 | 123943 | 0 | None | -32 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 1145 | 20 | 12 | 15 | 0.2 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)c2ccccc2N)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm1016208 | |||
| CHEMBL1765664 | 123943 | 0 | None | -32 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 1145 | 20 | 12 | 15 | 0.2 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)c2ccccc2N)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm1016208 | |||
| 52947354 | 40875 | 11 | None | -2 | 3 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 338 | 4 | 1 | 4 | 2.9 | CO/N=C1/C[C@@H](CO)N(C(=O)c2ccc(-c3ccccc3C)cc2)C1 | 10.1021/jm901812z | |||
| CHEMBL1254025 | 40875 | 11 | None | -2 | 3 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 338 | 4 | 1 | 4 | 2.9 | CO/N=C1/C[C@@H](CO)N(C(=O)c2ccc(-c3ccccc3C)cc2)C1 | 10.1021/jm901812z | |||
| DB16259 | 40875 | 11 | None | -2 | 3 | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 338 | 4 | 1 | 4 | 2.9 | CO/N=C1/C[C@@H](CO)N(C(=O)c2ccc(-c3ccccc3C)cc2)C1 | 10.1021/jm901812z | |||
| 54582318 | 123946 | 0 | None | -56 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1210 | 29 | 12 | 15 | 1.7 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCN)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm1016208 | |||
| CHEMBL1765668 | 123946 | 0 | None | -56 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1210 | 29 | 12 | 15 | 1.7 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCN)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm1016208 | |||
| 44361521 | 78556 | 0 | None | 1 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 450 | 7 | 2 | 4 | 2.9 | CC(=O)NCCCOc1ccc(C(=O)N2CCC(N3C(=O)NCc4ccccc43)CC2)cc1 | 10.1021/jm00023a002 | |||
| CHEMBL143341 | 78556 | 0 | None | 1 | 3 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 450 | 7 | 2 | 4 | 2.9 | CC(=O)NCCCOc1ccc(C(=O)N2CCC(N3C(=O)NCc4ccccc43)CC2)cc1 | 10.1021/jm00023a002 | |||
| 44316241 | 197234 | 0 | None | -5248 | 8 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1053 | 18 | 13 | 14 | -2.4 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| 44419029 | 197234 | 0 | None | -5248 | 8 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1053 | 18 | 13 | 14 | -2.4 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| CHEMBL265859 | 197234 | 0 | None | -5248 | 8 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1053 | 18 | 13 | 14 | -2.4 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| CHEMBL268306 | 197234 | 0 | None | -5248 | 8 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1053 | 18 | 13 | 14 | -2.4 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| 54584267 | 123945 | 0 | None | -35 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 1154 | 25 | 12 | 15 | 0.2 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCN)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm1016208 | |||
| CHEMBL1765667 | 123945 | 0 | None | -35 | 4 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 1154 | 25 | 12 | 15 | 0.2 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCN)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm1016208 | |||
| 16109441 | 274798 | 0 | None | -48 | 4 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 1026 | 19 | 12 | 15 | -2.8 | NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm060928n | |||
| CHEMBL375323 | 274798 | 0 | None | -48 | 4 | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 1026 | 19 | 12 | 15 | -2.8 | NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm060928n | |||
| 145963213 | 317022 | 0 | None | -3 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1095 | 17 | 11 | 14 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2ccccc2CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2018.03.019 | |||
| CHEMBL4127791 | 317022 | 0 | None | -3 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1095 | 17 | 11 | 14 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2ccccc2CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2018.03.019 | |||
| CHEMBL2369840 | 477600 | 0 | None | -28 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1126 | 18 | 13 | 14 | -1.9 | NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm030611c | |||
| CHEMBL2369829 | 477591 | 0 | None | -186 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1025 | 17 | 12 | 14 | -3.2 | CC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| 10444 | 4740 | 20 | None | 5 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 531 | 4 | 2 | 6 | 4.2 | Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C | 10.1021/acs.jmedchem.8b00697 | |||
| 145711714 | 4740 | 20 | None | 5 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 531 | 4 | 2 | 6 | 4.2 | Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL4204210 | 4740 | 20 | None | 5 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 531 | 4 | 2 | 6 | 4.2 | Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C | 10.1021/acs.jmedchem.8b00697 | |||
| 10602875 | 468553 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 556 | 7 | 0 | 7 | 4.9 | COc1cc(OC2CCN(Cc3ccccn3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL66567 | 468553 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 556 | 7 | 0 | 7 | 4.9 | COc1cc(OC2CCN(Cc3ccccn3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 114904 | 6013 | 43 | None | -8 | 5 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 449 | 7 | 1 | 4 | 3.2 | CC(=O)NCCCOc1ccc(cc1)C(=O)N1CCC(CC1)N1C(=O)CCc2c1cccc2 | 10.1021/jm00023a002 | |||
| 2196 | 6013 | 43 | None | -8 | 5 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 449 | 7 | 1 | 4 | 3.2 | CC(=O)NCCCOc1ccc(cc1)C(=O)N1CCC(CC1)N1C(=O)CCc2c1cccc2 | 10.1021/jm00023a002 | |||
| CHEMBL296908 | 6013 | 43 | None | -8 | 5 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 449 | 7 | 1 | 4 | 3.2 | CC(=O)NCCCOc1ccc(cc1)C(=O)N1CCC(CC1)N1C(=O)CCc2c1cccc2 | 10.1021/jm00023a002 | |||
| 135506374 | 275287 | 21 | None | -3 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1016/j.ejmech.2017.10.059 | |||
| CHEMBL3763342 | 275287 | 21 | None | -3 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1016/j.ejmech.2017.10.059 | |||
| 135506374 | 275287 | 21 | None | -3 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1016/j.ejmech.2015.11.050 | |||
| CHEMBL3763342 | 275287 | 21 | None | -3 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1016/j.ejmech.2015.11.050 | |||
| 114904 | 6013 | 43 | None | -8 | 5 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 449 | 7 | 1 | 4 | 3.2 | CC(=O)NCCCOc1ccc(cc1)C(=O)N1CCC(CC1)N1C(=O)CCc2c1cccc2 | 10.1021/jm901812z | |||
| 2196 | 6013 | 43 | None | -8 | 5 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 449 | 7 | 1 | 4 | 3.2 | CC(=O)NCCCOc1ccc(cc1)C(=O)N1CCC(CC1)N1C(=O)CCc2c1cccc2 | 10.1021/jm901812z | |||
| CHEMBL296908 | 6013 | 43 | None | -8 | 5 | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 449 | 7 | 1 | 4 | 3.2 | CC(=O)NCCCOc1ccc(cc1)C(=O)N1CCC(CC1)N1C(=O)CCc2c1cccc2 | 10.1021/jm901812z | |||
| 135613341 | 144599 | 4 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 423 | 7 | 2 | 5 | 3.1 | C/C(=N\NC(=O)CN(c1ccccc1)S(=O)(=O)c1ccccc1)c1ccccc1O | 10.1021/jm050645f | |||
| CHEMBL198630 | 144599 | 4 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 423 | 7 | 2 | 5 | 3.1 | C/C(=N\NC(=O)CN(c1ccccc1)S(=O)(=O)c1ccccc1)c1ccccc1O | 10.1021/jm050645f | |||
| 135491793 | 145190 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 498 | 6 | 2 | 5 | 5.8 | Cc1ccc(N(CC(=O)/N=N/c2c(O)[nH]c3ccccc23)S(=O)(=O)c2ccc3ccccc3c2)cc1 | 10.1021/jm050645f | |||
| CHEMBL200729 | 145190 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 498 | 6 | 2 | 5 | 5.8 | Cc1ccc(N(CC(=O)/N=N/c2c(O)[nH]c3ccccc23)S(=O)(=O)c2ccc3ccccc3c2)cc1 | 10.1021/jm050645f | |||
| 44361522 | 240294 | 0 | None | -4 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 477 | 4 | 0 | 5 | 3.8 | CC(=O)N1CCC(Oc2ccc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc2)CC1 | 10.1021/jm00023a002 | |||
| CHEMBL358793 | 240294 | 0 | None | -4 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 477 | 4 | 0 | 5 | 3.8 | CC(=O)N1CCC(Oc2ccc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc2)CC1 | 10.1021/jm00023a002 | |||
| 44419028 | 197233 | 21 | None | -199 | 8 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 1093 | 18 | 12 | 14 | -1.6 | NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm030611c | |||
| CHEMBL265858 | 197233 | 21 | None | -199 | 8 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 1093 | 18 | 12 | 14 | -1.6 | NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm030611c | |||
| CHEMBL2372253 | 477729 | 0 | None | None | None | Rat | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 1047 | 17 | 11 | 14 | -1.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2C(C(C)(C)C)CC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm990090m | |||
| 44275244 | 195608 | 0 | None | 2 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 424 | 6 | 0 | 5 | 3.8 | COc1ccc(CCC(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)c(OC)c1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL25611 | 195608 | 0 | None | 2 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 424 | 6 | 0 | 5 | 3.8 | COc1ccc(CCC(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)c(OC)c1 | 10.1016/s0960-894x(99)00181-x | |||
| 44361521 | 78556 | 0 | None | -1 | 3 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 450 | 7 | 2 | 4 | 2.9 | CC(=O)NCCCOc1ccc(C(=O)N2CCC(N3C(=O)NCc4ccccc43)CC2)cc1 | 10.1021/jm00023a002 | |||
| CHEMBL143341 | 78556 | 0 | None | -1 | 3 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 450 | 7 | 2 | 4 | 2.9 | CC(=O)NCCCOc1ccc(C(=O)N2CCC(N3C(=O)NCc4ccccc43)CC2)cc1 | 10.1021/jm00023a002 | |||
| 46233066 | 450837 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 632 | 5 | 1 | 6 | 4.4 | Cc1cc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1 | 10.1021/jm901084f | |||
| CHEMBL601930 | 450837 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 632 | 5 | 1 | 6 | 4.4 | Cc1cc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1 | 10.1021/jm901084f | |||
| 10507277 | 468944 | 0 | None | -2 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 570 | 7 | 0 | 7 | 5.2 | COc1cc(OC2CCN(Cc3cccnc3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL69520 | 468944 | 0 | None | -2 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 570 | 7 | 0 | 7 | 5.2 | COc1cc(OC2CCN(Cc3cccnc3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 1103817 | 40884 | 7 | None | 3 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 492 | 8 | 2 | 6 | 3.1 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(C)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL1254117 | 40884 | 7 | None | 3 | 4 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 492 | 8 | 2 | 6 | 3.1 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(C)cc2)cc1 | 10.1021/jm050645f | |||
| 135508167 | 160548 | 0 | None | -3 | 3 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 596 | 10 | 3 | 8 | 2.8 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(NCCN2CCOCC2)cc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm050645f | |||
| CHEMBL2113177 | 160548 | 0 | None | -3 | 3 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 596 | 10 | 3 | 8 | 2.8 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(NCCN2CCOCC2)cc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm050645f | |||
| 2202 | 5638 | 34 | None | -10 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 10.1016/j.bmcl.2011.03.012 | |||
| 9895468 | 5638 | 34 | None | -10 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 10.1016/j.bmcl.2011.03.012 | |||
| CHEMBL582857 | 5638 | 34 | None | -10 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 10.1016/j.bmcl.2011.03.012 | |||
| DB12643 | 5638 | 34 | None | -10 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 10.1016/j.bmcl.2011.03.012 | |||
| 44279676 | 215045 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 524 | 6 | 1 | 6 | 4.4 | O=C(Cc1cccnc1)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL31163 | 215045 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 524 | 6 | 1 | 6 | 4.4 | O=C(Cc1cccnc1)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00159-2 | |||
| 44279536 | 215195 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 559 | 6 | 1 | 7 | 2.7 | CN(Cc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1)C(=O)CN1C(=O)CNC1=O | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL31213 | 215195 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 559 | 6 | 1 | 7 | 2.7 | CN(Cc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1)C(=O)CN1C(=O)CNC1=O | 10.1016/s0960-894x(02)00159-2 | |||
| 44279368 | 217031 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 560 | 6 | 1 | 8 | 3.2 | CC1OC(=O)N(CC(=O)NCc2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)C1=O | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL31802 | 217031 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 560 | 6 | 1 | 8 | 3.2 | CC1OC(=O)N(CC(=O)NCc2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)C1=O | 10.1016/s0960-894x(02)00159-2 | |||
| 44279459 | 218855 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 487 | 3 | 0 | 5 | 4.9 | CC(=O)N1CCC[C@@H]1c1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL32187 | 218855 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 487 | 3 | 0 | 5 | 4.9 | CC(=O)N1CCC[C@@H]1c1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00159-2 | |||
| 44279238 | 318218 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 530 | 6 | 1 | 6 | 3.4 | O=C(CN1CCCC1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL417133 | 318218 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 530 | 6 | 1 | 6 | 3.4 | O=C(CN1CCCC1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00159-2 | |||
| 44280356 | 199504 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 634 | 5 | 0 | 7 | 6.2 | O=C(c1ccc2oc(CN3CCC[C@@H](n4cc(C(F)(F)F)ccc4=O)C3)cc2c1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL281988 | 199504 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 634 | 5 | 0 | 7 | 6.2 | O=C(c1ccc2oc(CN3CCC[C@@H](n4cc(C(F)(F)F)ccc4=O)C3)cc2c1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00160-9 | |||
| 44279689 | 200304 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 606 | 6 | 1 | 6 | 4.5 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)CCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL287629 | 200304 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 606 | 6 | 1 | 6 | 4.5 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)CCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| 11569672 | 143964 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 504 | 8 | 2 | 4 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(N(C)C)cc1 | 10.1021/jm050557v | |||
| 11656342 | 143964 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 504 | 8 | 2 | 4 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(N(C)C)cc1 | 10.1021/jm050557v | |||
| CHEMBL196603 | 143964 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 504 | 8 | 2 | 4 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(N(C)C)cc1 | 10.1021/jm050557v | |||
| CHEMBL371291 | 143964 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 504 | 8 | 2 | 4 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(N(C)C)cc1 | 10.1021/jm050557v | |||
| 11577790 | 278159 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 573 | 7 | 2 | 5 | 3.6 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccc(N2CCN(C)CC2)cc1 | 10.1021/jm050557v | |||
| CHEMBL382065 | 278159 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 573 | 7 | 2 | 5 | 3.6 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccc(N2CCN(C)CC2)cc1 | 10.1021/jm050557v | |||
| 44274620 | 194305 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 565 | 8 | 3 | 5 | 2.9 | CC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| 44274660 | 194305 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 565 | 8 | 3 | 5 | 2.9 | CC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL24806 | 194305 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 565 | 8 | 3 | 5 | 2.9 | CC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL422044 | 194305 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 565 | 8 | 3 | 5 | 2.9 | CC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| 10054193 | 199414 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 592 | 11 | 2 | 5 | 4.7 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)NCCc2ccc(Cl)c(Cl)c2)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL281403 | 199414 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 592 | 11 | 2 | 5 | 4.7 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)NCCc2ccc(Cl)c(Cl)c2)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL2369839 | 477599 | 0 | None | -16 | 4 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 1054 | 18 | 13 | 15 | -4.7 | NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm030611c | |||
| CHEMBL1790552 | 484810 | 0 | None | 1 | 2 | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 770 | 6 | 2 | 8 | 2.0 | CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCN(C)N2C(=O)[C@H]2CCCN(C)N2C1=O | 10.1021/jm00171a003 | |||
| 45103785 | 429849 | 0 | None | 1 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 584 | 4 | 1 | 5 | 4.6 | Cc1cc(C(=O)N2Cc3cccn3Cc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1 | 10.1021/jm901084f | |||
| CHEMBL590175 | 429849 | 0 | None | 1 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 584 | 4 | 1 | 5 | 4.6 | Cc1cc(C(=O)N2Cc3cccn3Cc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1 | 10.1021/jm901084f | |||
| 44278986 | 200088 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 376 | 2 | 0 | 4 | 4.2 | O=C(c1ccc2occc2c1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL286084 | 200088 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 376 | 2 | 0 | 4 | 4.2 | O=C(c1ccc2occc2c1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| 10413997 | 4534 | 5 | None | 1 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 510 | 6 | 2 | 4 | 3.6 | O=C(Cc1cnc[nH]1)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCC2(CC1)CCc1c2cccc1)(C)C | 10.1021/jm00077a002 | |||
| 2246 | 4534 | 5 | None | 1 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 510 | 6 | 2 | 4 | 3.6 | O=C(Cc1cnc[nH]1)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCC2(CC1)CCc1c2cccc1)(C)C | 10.1021/jm00077a002 | |||
| CHEMBL338522 | 4534 | 5 | None | 1 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 510 | 6 | 2 | 4 | 3.6 | O=C(Cc1cnc[nH]1)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCC2(CC1)CCc1c2cccc1)(C)C | 10.1021/jm00077a002 | |||
| 44335148 | 19471 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 512 | 5 | 0 | 5 | 5.9 | COc1cc(OC2CCCc3ccccc32)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL105733 | 19471 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 512 | 5 | 0 | 5 | 5.9 | COc1cc(OC2CCCc3ccccc32)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| 52946086 | 40867 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 457 | 7 | 2 | 5 | 3.4 | CO/N=C1\C[C@@H](C(=O)NCC(O)c2ccccc2)N(C(=O)c2ccc(-c3ccccc3)cc2)C1 | 10.1021/jm901812z | |||
| CHEMBL1253935 | 40867 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 457 | 7 | 2 | 5 | 3.4 | CO/N=C1\C[C@@H](C(=O)NCC(O)c2ccccc2)N(C(=O)c2ccc(-c3ccccc3)cc2)C1 | 10.1021/jm901812z | |||
| 10722297 | 468477 | 0 | None | -5 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 600 | 7 | 0 | 7 | 4.8 | COc1cc(OC2CCN(Cc3ccc(C)[n+]([O-])c3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL65949 | 468477 | 0 | None | -5 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 600 | 7 | 0 | 7 | 4.8 | COc1cc(OC2CCN(Cc3ccc(C)[n+]([O-])c3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 2213 | 1072 | 37 | None | -22 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm050645f | |||
| 3008 | 1072 | 37 | None | -22 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm050645f | |||
| 5311010 | 1072 | 37 | None | -22 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm050645f | |||
| 68613 | 1072 | 37 | None | -22 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm050645f | |||
| CHEMBL378642 | 1072 | 37 | None | -22 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm050645f | |||
| CHEMBL382301 | 1072 | 37 | None | -22 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm050645f | |||
| DB09059 | 1072 | 37 | None | -22 | 5 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm050645f | |||
| 136961690 | 237392 | 0 | None | 1 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 412 | 3 | 1 | 6 | 4.2 | Cc1ccn(Cc2ccc(C(=O)N3Cc4cnn(C)c4Nc4ccccc43)cc2C)n1 | 10.1021/jm501395b | |||
| CHEMBL3416757 | 237392 | 0 | None | 1 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 412 | 3 | 1 | 6 | 4.2 | Cc1ccn(Cc2ccc(C(=O)N3Cc4cnn(C)c4Nc4ccccc43)cc2C)n1 | 10.1021/jm501395b | |||
| 135916069 | 463841 | 0 | None | -1 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 398 | 2 | 1 | 6 | 4.1 | Cc1ccn(-c2ccc(C(=O)N3Cc4cnn(C)c4Nc4ccccc43)cc2C)n1 | 10.1021/jm901084f | |||
| CHEMBL605373 | 463841 | 0 | None | -1 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 398 | 2 | 1 | 6 | 4.1 | Cc1ccn(-c2ccc(C(=O)N3Cc4cnn(C)c4Nc4ccccc43)cc2C)n1 | 10.1021/jm901084f | |||
| 54584477 | 125114 | 0 | None | -10 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 631 | 8 | 1 | 11 | 1.7 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3nccnc3OC)(N3C[C@H](O)C[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)c(OC)c1 | 10.1016/j.bmcl.2011.03.012 | |||
| CHEMBL1779403 | 125114 | 0 | None | -10 | 3 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 631 | 8 | 1 | 11 | 1.7 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3nccnc3OC)(N3C[C@H](O)C[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)c(OC)c1 | 10.1016/j.bmcl.2011.03.012 | |||
| 11619807 | 145100 | 0 | None | -1 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 472 | 9 | 1 | 6 | 3.5 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C/c2ccccn2)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL200368 | 145100 | 0 | None | -1 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 472 | 9 | 1 | 6 | 3.5 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C/c2ccccn2)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| 11619807 | 145100 | 0 | None | -1 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 472 | 9 | 1 | 6 | 3.5 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C/c2ccccn2)c2ccc(Cl)cc2)cc1 | 10.1039/C5MD00566C | |||
| CHEMBL200368 | 145100 | 0 | None | -1 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 472 | 9 | 1 | 6 | 3.5 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C/c2ccccn2)c2ccc(Cl)cc2)cc1 | 10.1039/C5MD00566C | |||
| 44308876 | 468866 | 0 | None | -2 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 556 | 7 | 0 | 7 | 4.9 | COc1cc(OC2CCN(Cc3cccnc3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL68914 | 468866 | 0 | None | -2 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 556 | 7 | 0 | 7 | 4.9 | COc1cc(OC2CCN(Cc3cccnc3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 2192 | 4802 | 27 | None | 5 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 471 | 7 | 2 | 5 | 3.7 | CO/N=C/1\CN([C@@H](C1)C(=O)NC[C@H](c1ccccc1)O)C(=O)c1ccc(cc1)c1ccccc1C | 10.1021/jm901812z | |||
| 9690136 | 4802 | 27 | None | 5 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 471 | 7 | 2 | 5 | 3.7 | CO/N=C/1\CN([C@@H](C1)C(=O)NC[C@H](c1ccccc1)O)C(=O)c1ccc(cc1)c1ccccc1C | 10.1021/jm901812z | |||
| CHEMBL1254024 | 4802 | 27 | None | 5 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 471 | 7 | 2 | 5 | 3.7 | CO/N=C/1\CN([C@@H](C1)C(=O)NC[C@H](c1ccccc1)O)C(=O)c1ccc(cc1)c1ccccc1C | 10.1021/jm901812z | |||
| 44579399 | 370412 | 0 | None | 19 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 368 | 8 | 0 | 7 | 3.6 | CCOCc1nnc(-c2ccc(OCC)c(C)c2)n1-c1ccc(OC)nc1 | 10.1021/jm901812z | |||
| CHEMBL492029 | 370412 | 0 | None | 19 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 368 | 8 | 0 | 7 | 3.6 | CCOCc1nnc(-c2ccc(OCC)c(C)c2)n1-c1ccc(OC)nc1 | 10.1021/jm901812z | |||
| 2192 | 4802 | 27 | None | 5 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 471 | 7 | 2 | 5 | 3.7 | CO/N=C/1\CN([C@@H](C1)C(=O)NC[C@H](c1ccccc1)O)C(=O)c1ccc(cc1)c1ccccc1C | 10.1021/jm901812z | |||
| 9690136 | 4802 | 27 | None | 5 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 471 | 7 | 2 | 5 | 3.7 | CO/N=C/1\CN([C@@H](C1)C(=O)NC[C@H](c1ccccc1)O)C(=O)c1ccc(cc1)c1ccccc1C | 10.1021/jm901812z | |||
| CHEMBL1254024 | 4802 | 27 | None | 5 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 471 | 7 | 2 | 5 | 3.7 | CO/N=C/1\CN([C@@H](C1)C(=O)NC[C@H](c1ccccc1)O)C(=O)c1ccc(cc1)c1ccccc1C | 10.1021/jm901812z | |||
| 57520031 | 155346 | 0 | None | 131 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 555 | 7 | 0 | 6 | 3.0 | COc1cc(OC2CCN(S(C)(=O)=O)CC2)ccc1CC(=O)N1CCC(N2C(=O)CCc3ccccc32)CC1 | 10.1016/j.bmc.2012.02.019 | |||
| CHEMBL2017979 | 155346 | 0 | None | 131 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 555 | 7 | 0 | 6 | 3.0 | COc1cc(OC2CCN(S(C)(=O)=O)CC2)ccc1CC(=O)N1CCC(N2C(=O)CCc3ccccc32)CC1 | 10.1016/j.bmc.2012.02.019 | |||
| 54584478 | 125117 | 0 | None | -354 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 666 | 9 | 0 | 8 | 4.5 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3ccc(CN4CCCC4)cc3OC)(N3CCC[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)cc1 | 10.1016/j.bmcl.2011.03.012 | |||
| CHEMBL1779406 | 125117 | 0 | None | -354 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 666 | 9 | 0 | 8 | 4.5 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3ccc(CN4CCCC4)cc3OC)(N3CCC[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)cc1 | 10.1016/j.bmcl.2011.03.012 | |||
| 10721511 | 202732 | 0 | None | 2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 555 | 7 | 0 | 6 | 5.5 | COc1cc(OC2CCN(Cc3ccccc3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL304577 | 202732 | 0 | None | 2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 555 | 7 | 0 | 6 | 5.5 | COc1cc(OC2CCN(Cc3ccccc3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 10840517 | 468876 | 0 | None | -3 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 556 | 7 | 0 | 7 | 4.9 | COc1cc(OC2CCN(Cc3ccncc3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL68978 | 468876 | 0 | None | -3 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 556 | 7 | 0 | 7 | 4.9 | COc1cc(OC2CCN(Cc3ccncc3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 10793202 | 468947 | 0 | None | -2 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 572 | 7 | 0 | 7 | 4.1 | COc1cc(OC2CCN(Cc3ccc[n+]([O-])c3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL69539 | 468947 | 0 | None | -2 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 572 | 7 | 0 | 7 | 4.1 | COc1cc(OC2CCN(Cc3ccc[n+]([O-])c3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 54584265 | 123942 | 0 | None | -54 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1026 | 18 | 11 | 14 | -0.9 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm1016208 | |||
| CHEMBL1765663 | 123942 | 0 | None | -54 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1026 | 18 | 11 | 14 | -0.9 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm1016208 | |||
| 54581529 | 125119 | 0 | None | -112 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 696 | 10 | 0 | 9 | 4.5 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3cc(CN4CCCC4)ccc3OC)(N3CCC[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)c(OC)c1 | 10.1016/j.bmcl.2011.03.012 | |||
| CHEMBL1779408 | 125119 | 0 | None | -112 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 696 | 10 | 0 | 9 | 4.5 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3cc(CN4CCCC4)ccc3OC)(N3CCC[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)c(OC)c1 | 10.1016/j.bmcl.2011.03.012 | |||
| 10510242 | 238988 | 0 | None | None | None | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1023 | 17 | 11 | 15 | -1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm9607156 | |||
| 11083629 | 238988 | 0 | None | None | None | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1023 | 17 | 11 | 15 | -1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm9607156 | |||
| CHEMBL352836 | 238988 | 0 | None | None | None | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1023 | 17 | 11 | 15 | -1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm9607156 | |||
| CHEMBL353396 | 238988 | 0 | None | None | None | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1023 | 17 | 11 | 15 | -1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm9607156 | |||
| 135414531 | 160566 | 0 | None | 3 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 586 | 13 | 2 | 8 | 3.1 | COCCOCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113208 | 160566 | 0 | None | 3 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 586 | 13 | 2 | 8 | 3.1 | COCCOCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| 155532160 | 336257 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1006 | 21 | 13 | 15 | -4.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CCSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | |||
| CHEMBL4467042 | 336257 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1006 | 21 | 13 | 15 | -4.6 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CCSC[C@@H](C(=O)N(CCCO)CC(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/acs.jmedchem.8b01691 | |||
| 135414531 | 160566 | 0 | None | 3 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 586 | 13 | 2 | 8 | 3.1 | COCCOCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1039/C5MD00566C | |||
| CHEMBL2113208 | 160566 | 0 | None | 3 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 586 | 13 | 2 | 8 | 3.1 | COCCOCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1039/C5MD00566C | |||
| 44279410 | 196816 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 559 | 6 | 1 | 7 | 2.7 | CN1CC(=O)N(CC(=O)NCc2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)C1=O | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL262384 | 196816 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 559 | 6 | 1 | 7 | 2.7 | CN1CC(=O)N(CC(=O)NCc2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)C1=O | 10.1016/s0960-894x(02)00159-2 | |||
| 44456270 | 311352 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 466 | 6 | 1 | 5 | 2.6 | Cc1nc([C@H](C(=O)N(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)c(C)o1 | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL403477 | 311352 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 466 | 6 | 1 | 5 | 2.6 | Cc1nc([C@H](C(=O)N(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)c(C)o1 | 10.1016/j.bmcl.2007.11.008 | |||
| 11758421 | 199862 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 609 | 6 | 1 | 8 | 4.1 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cnc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL284442 | 199862 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 609 | 6 | 1 | 8 | 4.1 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cnc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| 44279542 | 216828 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 642 | 6 | 1 | 7 | 5.3 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccc(Cl)cc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL31651 | 216828 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 642 | 6 | 1 | 7 | 5.3 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccc(Cl)cc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| 11569672 | 143964 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 504 | 8 | 2 | 4 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(N(C)C)cc1 | 10.1021/jm901812z | |||
| 11656342 | 143964 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 504 | 8 | 2 | 4 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(N(C)C)cc1 | 10.1021/jm901812z | |||
| CHEMBL196603 | 143964 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 504 | 8 | 2 | 4 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(N(C)C)cc1 | 10.1021/jm901812z | |||
| CHEMBL371291 | 143964 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 504 | 8 | 2 | 4 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(N(C)C)cc1 | 10.1021/jm901812z | |||
| 11569672 | 143964 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 504 | 8 | 2 | 4 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(N(C)C)cc1 | 10.1021/jm060073e | |||
| 11656342 | 143964 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 504 | 8 | 2 | 4 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(N(C)C)cc1 | 10.1021/jm060073e | |||
| CHEMBL196603 | 143964 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 504 | 8 | 2 | 4 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(N(C)C)cc1 | 10.1021/jm060073e | |||
| CHEMBL371291 | 143964 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 504 | 8 | 2 | 4 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(N(C)C)cc1 | 10.1021/jm060073e | |||
| 11569672 | 143964 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 504 | 8 | 2 | 4 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(N(C)C)cc1 | 10.1021/jm050557v | |||
| 11656342 | 143964 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 504 | 8 | 2 | 4 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(N(C)C)cc1 | 10.1021/jm050557v | |||
| CHEMBL196603 | 143964 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 504 | 8 | 2 | 4 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(N(C)C)cc1 | 10.1021/jm050557v | |||
| CHEMBL371291 | 143964 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 504 | 8 | 2 | 4 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(N(C)C)cc1 | 10.1021/jm050557v | |||
| 56949759 | 156983 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 464 | 6 | 2 | 5 | 2.1 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(O)nc1 | 10.1021/jm201287w | |||
| CHEMBL2037488 | 156983 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 464 | 6 | 2 | 5 | 2.1 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C)c1ccc(O)nc1 | 10.1021/jm201287w | |||
| 3126 | 484342 | 1 | None | None | None | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 991 | 17 | 11 | 14 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm990090m | |||
| CHEMBL435716 | 484342 | 1 | None | None | None | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 991 | 17 | 11 | 14 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm990090m | |||
| 10723001 | 202424 | 0 | None | -3 | 2 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 658 | 7 | 0 | 7 | 5.3 | COc1cc(OC2CCN(Cc3ccc[n+]([O-])c3C(F)(F)F)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL303700 | 202424 | 0 | None | -3 | 2 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 658 | 7 | 0 | 7 | 5.3 | COc1cc(OC2CCN(Cc3ccc[n+]([O-])c3C(F)(F)F)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 10603858 | 468859 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 616 | 6 | 0 | 7 | 4.8 | COc1cc(OC2CCN(C3CCc4c3ccc[n+]4[O-])CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL68816 | 468859 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 616 | 6 | 0 | 7 | 4.8 | COc1cc(OC2CCN(C3CCc4c3ccc[n+]4[O-])CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL1790551 | 484809 | 0 | None | 229 | 2 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 795 | 8 | 2 | 9 | 2.1 | CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2C[C@@H](CN(C)C)C=NN2C(=O)[C@H]2CCC=NN2C1=O | 10.1021/jm00171a003 | |||
| 10627984 | 468607 | 0 | None | -4 | 2 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 646 | 8 | 0 | 7 | 5.5 | CCc1c(CN2CCC(Oc3cc(OC)c(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)cc3F)CC2)c(C)cc(C)[n+]1[O-] | 10.1021/jm9800797 | |||
| CHEMBL66985 | 468607 | 0 | None | -4 | 2 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 646 | 8 | 0 | 7 | 5.5 | CCc1c(CN2CCC(Oc3cc(OC)c(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)cc3F)CC2)c(C)cc(C)[n+]1[O-] | 10.1021/jm9800797 | |||
| CHEMBL435021 | 488610 | 4 | None | 1 | 2 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 780 | 6 | 4 | 7 | 2.0 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CNCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 10841081 | 202393 | 0 | None | 3 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 586 | 7 | 0 | 7 | 4.4 | COc1cc(OC2CCN(Cc3c[n+]([O-])ccc3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL303487 | 202393 | 0 | None | 3 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 586 | 7 | 0 | 7 | 4.4 | COc1cc(OC2CCN(Cc3c[n+]([O-])ccc3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 2249 | 4540 | 14 | None | 1 | 7 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 554 | 9 | 2 | 7 | 1.5 | O=C([C@H](CCS(=O)(=O)C)N)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ccccc1C)(C)C | 10.1021/jm901812z | |||
| 9872389 | 4540 | 14 | None | 1 | 7 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 554 | 9 | 2 | 7 | 1.5 | O=C([C@H](CCS(=O)(=O)C)N)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ccccc1C)(C)C | 10.1021/jm901812z | |||
| CHEMBL1253853 | 4540 | 14 | None | 1 | 7 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 554 | 9 | 2 | 7 | 1.5 | O=C([C@H](CCS(=O)(=O)C)N)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ccccc1C)(C)C | 10.1021/jm901812z | |||
| 127049296 | 277954 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 1019 | 17 | 9 | 14 | -1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | |||
| CHEMBL3815099 | 277954 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 1019 | 17 | 9 | 14 | -1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC(C)C)C(=O)N(C)CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | |||
| 135466581 | 160557 | 0 | None | 120 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 512 | 8 | 2 | 6 | 3.4 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1039/C5MD00566C | |||
| CHEMBL2113198 | 160557 | 0 | None | 120 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 512 | 8 | 2 | 6 | 3.4 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1039/C5MD00566C | |||
| 44335184 | 212985 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 487 | 6 | 0 | 6 | 5.0 | COc1cc(O[C@H](C)c2ccncc2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL322187 | 212985 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 487 | 6 | 0 | 6 | 5.0 | COc1cc(O[C@H](C)c2ccncc2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| 135466581 | 160557 | 0 | None | 120 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 512 | 8 | 2 | 6 | 3.4 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113198 | 160557 | 0 | None | 120 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 512 | 8 | 2 | 6 | 3.4 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| 44279369 | 199203 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 573 | 6 | 1 | 7 | 3.1 | CN1CCC(=O)N(CC(=O)NCc2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)C1=O | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL279782 | 199203 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 573 | 6 | 1 | 7 | 3.1 | CN1CCC(=O)N(CC(=O)NCc2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)C1=O | 10.1016/s0960-894x(02)00159-2 | |||
| 56950449 | 156710 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 495 | 7 | 2 | 3 | 4.1 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccccc1Cl | 10.1021/jm201287w | |||
| CHEMBL2035009 | 156710 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 495 | 7 | 2 | 3 | 4.1 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccccc1Cl | 10.1021/jm201287w | |||
| 44581269 | 372851 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 446 | 7 | 0 | 6 | 4.3 | COc1ccc(N(Cc2ccc(-c3ccccc3C)cn2)S(=O)(=O)c2ccccn2)cn1 | 10.1016/j.bmcl.2008.11.018 | |||
| CHEMBL515818 | 372851 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 446 | 7 | 0 | 6 | 4.3 | COc1ccc(N(Cc2ccc(-c3ccccc3C)cn2)S(=O)(=O)c2ccccn2)cn1 | 10.1016/j.bmcl.2008.11.018 | |||
| 44279590 | 219879 | 0 | None | 1000 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 609 | 6 | 1 | 8 | 4.1 | O=C(Cn1cnc(C(F)(F)F)cc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL32404 | 219879 | 0 | None | 1000 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 609 | 6 | 1 | 8 | 4.1 | O=C(Cn1cnc(C(F)(F)F)cc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| 11569194 | 144330 | 0 | None | 63 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 479 | 7 | 2 | 3 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(F)cc1 | 10.1021/jm901812z | |||
| 11619939 | 144330 | 0 | None | 63 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 479 | 7 | 2 | 3 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(F)cc1 | 10.1021/jm901812z | |||
| CHEMBL197793 | 144330 | 0 | None | 63 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 479 | 7 | 2 | 3 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(F)cc1 | 10.1021/jm901812z | |||
| CHEMBL427353 | 144330 | 0 | None | 63 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 479 | 7 | 2 | 3 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(F)cc1 | 10.1021/jm901812z | |||
| 11341369 | 161068 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 519 | 6 | 2 | 5 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccc2c(c1)OCO2 | 10.1021/jm060073e | |||
| CHEMBL211440 | 161068 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 519 | 6 | 2 | 5 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccc2c(c1)OCO2 | 10.1021/jm060073e | |||
| 11570523 | 161546 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 574 | 7 | 3 | 5 | 3.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccc(N2CCC(O)CC2)cc1 | 10.1021/jm060073e | |||
| CHEMBL213112 | 161546 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 574 | 7 | 3 | 5 | 3.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccc(N2CCC(O)CC2)cc1 | 10.1021/jm060073e | |||
| 11634960 | 276572 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 517 | 6 | 2 | 4 | 3.7 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccc2c(c1)CCO2 | 10.1021/jm060073e | |||
| CHEMBL378939 | 276572 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 517 | 6 | 2 | 4 | 3.7 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccc2c(c1)CCO2 | 10.1021/jm060073e | |||
| 11612607 | 142825 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 475 | 7 | 2 | 3 | 3.7 | Cc1ccc([C@@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| 11691416 | 142825 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 475 | 7 | 2 | 3 | 3.7 | Cc1ccc([C@@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| CHEMBL194922 | 142825 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 475 | 7 | 2 | 3 | 3.7 | Cc1ccc([C@@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| CHEMBL555148 | 142825 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 475 | 7 | 2 | 3 | 3.7 | Cc1ccc([C@@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| 11569194 | 144330 | 0 | None | 63 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 479 | 7 | 2 | 3 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(F)cc1 | 10.1021/jm050557v | |||
| 11619939 | 144330 | 0 | None | 63 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 479 | 7 | 2 | 3 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(F)cc1 | 10.1021/jm050557v | |||
| CHEMBL197793 | 144330 | 0 | None | 63 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 479 | 7 | 2 | 3 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(F)cc1 | 10.1021/jm050557v | |||
| CHEMBL427353 | 144330 | 0 | None | 63 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 479 | 7 | 2 | 3 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc(F)cc1 | 10.1021/jm050557v | |||
| 11363194 | 198471 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 461 | 7 | 2 | 3 | 3.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccccc1 | 10.1021/jm050557v | |||
| 11641200 | 198471 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 461 | 7 | 2 | 3 | 3.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccccc1 | 10.1021/jm050557v | |||
| CHEMBL273988 | 198471 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 461 | 7 | 2 | 3 | 3.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccccc1 | 10.1021/jm050557v | |||
| CHEMBL382518 | 198471 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 461 | 7 | 2 | 3 | 3.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccccc1 | 10.1021/jm050557v | |||
| 11677260 | 273133 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 475 | 7 | 1 | 3 | 3.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C(C)C)c1ccccc1 | 10.1021/jm050557v | |||
| CHEMBL372978 | 273133 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 475 | 7 | 1 | 3 | 3.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N(C)C(C)C)c1ccccc1 | 10.1021/jm050557v | |||
| CHEMBL1790548 | 484807 | 0 | None | 50 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 742 | 6 | 4 | 8 | 1.3 | CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCNN2C(=O)[C@H]2CCCNN2C1=O | 10.1021/jm00171a003 | |||
| 10627414 | 468768 | 0 | None | -5 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 600 | 7 | 0 | 7 | 4.8 | COc1cc(OC2CCN(Cc3c[n+]([O-])c(C)cc3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL68199 | 468768 | 0 | None | -5 | 2 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 600 | 7 | 0 | 7 | 4.8 | COc1cc(OC2CCN(Cc3c[n+]([O-])c(C)cc3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 11740743 | 38028 | 0 | None | -6 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 384 | 3 | 1 | 2 | 5.2 | Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1 | 10.1021/jm3006146 | |||
| CHEMBL119793 | 38028 | 0 | None | -6 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 384 | 3 | 1 | 2 | 5.2 | Cc1ccccc1C(=O)Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1 | 10.1021/jm3006146 | |||
| 54583310 | 125811 | 0 | None | -25 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1542 | 24 | 16 | 22 | 1.4 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)c2ccc(-c3c4ccc(=N)c(S(=O)(=O)O)c-4oc4c(S(=O)(=O)O)c(N)ccc34)c(C(=O)O)c2)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm1016208 | |||
| CHEMBL1789128 | 125811 | 0 | None | -25 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1542 | 24 | 16 | 22 | 1.4 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)c2ccc(-c3c4ccc(=N)c(S(=O)(=O)O)c-4oc4c(S(=O)(=O)O)c(N)ccc34)c(C(=O)O)c2)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm1016208 | |||
| 135506374 | 275287 | 21 | None | -3 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL3763342 | 275287 | 21 | None | -3 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.8b00697 | |||
| 44215484 | 352491 | 0 | None | -10 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 440 | 7 | 0 | 6 | 4.6 | Cc1nnc(-c2ccc(-c3ccccc3)cc2)n1-c1ccccc1OCCN1CCOCC1 | 10.1021/jm901812z | |||
| CHEMBL467154 | 352491 | 0 | None | -10 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 440 | 7 | 0 | 6 | 4.6 | Cc1nnc(-c2ccc(-c3ccccc3)cc2)n1-c1ccccc1OCCN1CCOCC1 | 10.1021/jm901812z | |||
| 71451750 | 163805 | 0 | None | -1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 1295 | 30 | 4 | 17 | 7.6 | CCN(CC)c1ccc2c(-c3ccc(S(=O)(=O)[O-])cc3S(=O)(=O)NCCOCCOCCOCCn3cc(CNC(=O)CCC(=O)NC4CCCN(C(=O)c5ccc(NC(=O)c6ccccc6C)cc5)c5ccccc54)nn3)c3ccc(=[N+](CC)CC)cc-3oc2c1 | 10.1021/jm3006146 | |||
| CHEMBL2172292 | 163805 | 0 | None | -1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 1295 | 30 | 4 | 17 | 7.6 | CCN(CC)c1ccc2c(-c3ccc(S(=O)(=O)[O-])cc3S(=O)(=O)NCCOCCOCCOCCn3cc(CNC(=O)CCC(=O)NC4CCCN(C(=O)c5ccc(NC(=O)c6ccccc6C)cc5)c5ccccc54)nn3)c3ccc(=[N+](CC)CC)cc-3oc2c1 | 10.1021/jm3006146 | |||
| CHEMBL3814617 | 487603 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1020 | 17 | 11 | 15 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)N(C)C(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | |||
| 56950452 | 156713 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 529 | 7 | 2 | 3 | 4.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccccc1C(F)(F)F | 10.1021/jm201287w | |||
| CHEMBL2035012 | 156713 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 529 | 7 | 2 | 3 | 4.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccccc1C(F)(F)F | 10.1021/jm201287w | |||
| 56950589 | 156714 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 491 | 8 | 2 | 4 | 3.4 | COc1ccccc1[C@H](C(=O)NC(C)C)N1C(=O)[C@@H](C2Cc3ccccc3C2)NC(=O)[C@H]1CC(C)C | 10.1021/jm201287w | |||
| CHEMBL2035013 | 156714 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 491 | 8 | 2 | 4 | 3.4 | COc1ccccc1[C@H](C(=O)NC(C)C)N1C(=O)[C@@H](C2Cc3ccccc3C2)NC(=O)[C@H]1CC(C)C | 10.1021/jm201287w | |||
| 44404013 | 143997 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 504 | 8 | 3 | 4 | 2.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccc(C(N)=O)cc1 | 10.1021/jm050557v | |||
| 44404031 | 143997 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 504 | 8 | 3 | 4 | 2.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccc(C(N)=O)cc1 | 10.1021/jm050557v | |||
| CHEMBL196688 | 143997 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 504 | 8 | 3 | 4 | 2.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccc(C(N)=O)cc1 | 10.1021/jm050557v | |||
| CHEMBL197298 | 143997 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 504 | 8 | 3 | 4 | 2.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccc(C(N)=O)cc1 | 10.1021/jm050557v | |||
| 44275003 | 198922 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 641 | 12 | 3 | 6 | 4.1 | CC(=O)CCCC(=O)NC1N=C(C2CCCCC2)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL277425 | 198922 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 641 | 12 | 3 | 6 | 4.1 | CC(=O)CCCC(=O)NC1N=C(C2CCCCC2)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| 44279509 | 199939 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 496 | 6 | 1 | 6 | 3.0 | CS(=O)(=O)NCCn1ccc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc21 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL285013 | 199939 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 496 | 6 | 1 | 6 | 3.0 | CS(=O)(=O)NCCn1ccc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc21 | 10.1016/s0960-894x(02)00159-2 | |||
| 11525173 | 142558 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 447 | 7 | 2 | 3 | 3.9 | CC(C)C[C@@H]1CN[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccccc1 | 10.1021/jm050557v | |||
| CHEMBL194431 | 142558 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 447 | 7 | 2 | 3 | 3.9 | CC(C)C[C@@H]1CN[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccccc1 | 10.1021/jm050557v | |||
| 44275048 | 195136 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 524 | 11 | 2 | 5 | 3.4 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)NCCc2ccccc2)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL25310 | 195136 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 524 | 11 | 2 | 5 | 3.4 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)NCCc2ccccc2)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| 2213 | 1072 | 37 | None | -22 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2007.11.008 | |||
| 3008 | 1072 | 37 | None | -22 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2007.11.008 | |||
| 5311010 | 1072 | 37 | None | -22 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2007.11.008 | |||
| 68613 | 1072 | 37 | None | -22 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL378642 | 1072 | 37 | None | -22 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL382301 | 1072 | 37 | None | -22 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2007.11.008 | |||
| DB09059 | 1072 | 37 | None | -22 | 5 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2007.11.008 | |||
| 10208363 | 144594 | 0 | None | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 523 | 9 | 1 | 6 | 2.7 | CCOc1ccc(S(=O)(=O)N(CC(=O)N2Cc3ccccc3CC2C(N)=O)c2ccc(OC)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL198622 | 144594 | 0 | None | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 523 | 9 | 1 | 6 | 2.7 | CCOc1ccc(S(=O)(=O)N(CC(=O)N2Cc3ccccc3CC2C(N)=O)c2ccc(OC)cc2)cc1 | 10.1021/jm050645f | |||
| 53358903 | 125107 | 0 | None | -1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 499 | 6 | 1 | 7 | 3.2 | COc1ccc2c(c1)c(CC(=O)N1CCCNCC1)c(C)n2S(=O)(=O)c1ccc(OC)c(C)c1C | 10.1016/j.bmcl.2011.04.104 | |||
| CHEMBL1779235 | 125107 | 0 | None | -1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 499 | 6 | 1 | 7 | 3.2 | COc1ccc2c(c1)c(CC(=O)N1CCCNCC1)c(C)n2S(=O)(=O)c1ccc(OC)c(C)c1C | 10.1016/j.bmcl.2011.04.104 | |||
| 135461396 | 160555 | 0 | None | 3 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 626 | 13 | 2 | 8 | 2.2 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)N(CC(N)=O)c3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113196 | 160555 | 0 | None | 3 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 626 | 13 | 2 | 8 | 2.2 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)N(CC(N)=O)c3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| 145976595 | 328683 | 0 | None | -8 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 408 | 2 | 1 | 4 | 4.9 | Cc1ccn(C(=O)Nc2ccc(C(=O)N3CCCCc4ccccc43)c(Cl)c2)n1 | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL4205046 | 328683 | 0 | None | -8 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 408 | 2 | 1 | 4 | 4.9 | Cc1ccn(C(=O)Nc2ccc(C(=O)N3CCCCc4ccccc43)c(Cl)c2)n1 | 10.1021/acs.jmedchem.8b00697 | |||
| 11366713 | 274628 | 0 | None | -724 | 8 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 1054 | 19 | 13 | 15 | -3.9 | NCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| CHEMBL375096 | 274628 | 0 | None | -724 | 8 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 1054 | 19 | 13 | 15 | -3.9 | NCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| 44275617 | 197561 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 410 | 5 | 0 | 5 | 3.4 | COc1ccc(CC(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)c(OC)c1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL26877 | 197561 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 410 | 5 | 0 | 5 | 3.4 | COc1ccc(CC(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)c(OC)c1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL338308 | 487001 | 0 | None | -4 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 742 | 9 | 4 | 8 | 1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCN)NC(=O)[C@H]2CCC=NN2C1=O | 10.1021/jm00099a019 | |||
| 135469685 | 160569 | 0 | None | -4 | 3 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 542 | 10 | 2 | 7 | 3.0 | COCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113211 | 160569 | 0 | None | -4 | 3 | Rat | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 542 | 10 | 2 | 7 | 3.0 | COCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL3814120 | 487598 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1034 | 17 | 10 | 15 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N(C)CC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | |||
| 44361403 | 67461 | 1 | None | -14 | 5 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 491 | 5 | 0 | 5 | 4.1 | CC(=O)N1CCCC(COc2ccc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc2)C1 | 10.1021/jm00023a002 | |||
| CHEMBL142324 | 67461 | 1 | None | -14 | 5 | Rat | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 491 | 5 | 0 | 5 | 4.1 | CC(=O)N1CCCC(COc2ccc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc2)C1 | 10.1021/jm00023a002 | |||
| 145964296 | 329079 | 0 | None | -1 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 329 | 2 | 0 | 3 | 4.1 | O=C(c1ccc(-c2ncccn2)cc1)N1CCCCc2ccccc21 | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL4209952 | 329079 | 0 | None | -1 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 329 | 2 | 0 | 3 | 4.1 | O=C(c1ccc(-c2ncccn2)cc1)N1CCCCc2ccccc21 | 10.1021/acs.jmedchem.8b00697 | |||
| 44419039 | 274799 | 0 | None | -27542 | 8 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 1096 | 20 | 14 | 15 | -4.6 | NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm060928n | |||
| CHEMBL375324 | 274799 | 0 | None | -27542 | 8 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 1096 | 20 | 14 | 15 | -4.6 | NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm060928n | |||
| 10602875 | 468553 | 0 | None | -1 | 2 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 556 | 7 | 0 | 7 | 4.9 | COc1cc(OC2CCN(Cc3ccccn3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL66567 | 468553 | 0 | None | -1 | 2 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 556 | 7 | 0 | 7 | 4.9 | COc1cc(OC2CCN(Cc3ccccn3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 44275233 | 199134 | 0 | None | -3 | 2 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 521 | 6 | 0 | 6 | 3.8 | COc1cc(OC2CCN(C(C)=O)CC2)ccc1CC(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL279230 | 199134 | 0 | None | -3 | 2 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 521 | 6 | 0 | 6 | 3.8 | COc1cc(OC2CCN(C(C)=O)CC2)ccc1CC(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| 135461089 | 145109 | 4 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 478 | 8 | 2 | 6 | 4.8 | CCOc1ccc(S(=O)(=O)N(CC(=O)/N=N/c2c(O)[nH]c3ccccc23)c2ccccc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL200403 | 145109 | 4 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 478 | 8 | 2 | 6 | 4.8 | CCOc1ccc(S(=O)(=O)N(CC(=O)/N=N/c2c(O)[nH]c3ccccc23)c2ccccc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL491224 | 145109 | 4 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 478 | 8 | 2 | 6 | 4.8 | CCOc1ccc(S(=O)(=O)N(CC(=O)/N=N/c2c(O)[nH]c3ccccc23)c2ccccc2)cc1 | 10.1021/jm050645f | |||
| 135438380 | 160570 | 0 | None | 58 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 510 | 8 | 2 | 5 | 4.0 | CCCc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113212 | 160570 | 0 | None | 58 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 510 | 8 | 2 | 5 | 4.0 | CCCc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2369848 | 477605 | 0 | None | -77 | 4 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 1093 | 18 | 12 | 15 | -2.3 | NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2cccs2)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm030611c | |||
| 44275617 | 197561 | 0 | None | -1 | 2 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 410 | 5 | 0 | 5 | 3.4 | COc1ccc(CC(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)c(OC)c1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL26877 | 197561 | 0 | None | -1 | 2 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 410 | 5 | 0 | 5 | 3.4 | COc1ccc(CC(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)c(OC)c1 | 10.1016/s0960-894x(99)00181-x | |||
| 135446051 | 160562 | 0 | None | 13 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 474 | 6 | 2 | 6 | 3.1 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1cccs1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm050645f | |||
| CHEMBL2113204 | 160562 | 0 | None | 13 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 474 | 6 | 2 | 6 | 3.1 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1cccs1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm050645f | |||
| 16109447 | 164761 | 0 | None | -40 | 4 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 1012 | 18 | 12 | 15 | -3.2 | NCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| CHEMBL219272 | 164761 | 0 | None | -40 | 4 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 1012 | 18 | 12 | 15 | -3.2 | NCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| 145970757 | 329707 | 0 | None | -1 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 307 | 4 | 0 | 1 | 5.0 | CCCCc1ccc(C(=O)N2CCCCc3ccccc32)cc1 | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL4218211 | 329707 | 0 | None | -1 | 3 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 307 | 4 | 0 | 1 | 5.0 | CCCCc1ccc(C(=O)N2CCCCc3ccccc32)cc1 | 10.1021/acs.jmedchem.8b00697 | |||
| 44297505 | 330720 | 0 | None | -173 | 3 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 1329 | 38 | 15 | 16 | -1.8 | CN(C(=O)CCc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | 10.1021/jm00038a013 | |||
| CHEMBL424905 | 330720 | 0 | None | -173 | 3 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 1329 | 38 | 15 | 16 | -1.8 | CN(C(=O)CCc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | 10.1021/jm00038a013 | |||
| 9981665 | 232117 | 5 | None | 1 | 6 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 459 | 5 | 2 | 4 | 3.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CC(=O)O)C2 | 10.1021/jm901812z | |||
| CHEMBL341339 | 232117 | 5 | None | 1 | 6 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 459 | 5 | 2 | 4 | 3.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CC(=O)O)C2 | 10.1021/jm901812z | |||
| 54584268 | 123948 | 0 | None | -446 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 1226 | 29 | 13 | 16 | 0.7 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)C(O)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCN)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm1016208 | |||
| CHEMBL1765671 | 123948 | 0 | None | -446 | 4 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 1226 | 29 | 13 | 16 | 0.7 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)C(O)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCN)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm1016208 | |||
| 53364234 | 136389 | 0 | None | -1584 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 485 | 8 | 2 | 3 | 4.2 | CN(C)[C@H]1CC[C@H](NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2(c3ccc(F)cc3)CC2)CC1 | 10.1016/j.bmcl.2011.05.092 | |||
| CHEMBL1807273 | 136389 | 0 | None | -1584 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 485 | 8 | 2 | 3 | 4.2 | CN(C)[C@H]1CC[C@H](NC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C2(c3ccc(F)cc3)CC2)CC1 | 10.1016/j.bmcl.2011.05.092 | |||
| 145965794 | 329318 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 462 | 5 | 3 | 7 | 2.6 | COC(=O)CNC(=O)NCc1ccc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)cc1C | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL4212928 | 329318 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 462 | 5 | 3 | 7 | 2.6 | COC(=O)CNC(=O)NCc1ccc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)cc1C | 10.1021/acs.jmedchem.8b00697 | |||
| 44279555 | 202338 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 510 | 6 | 0 | 6 | 3.3 | CN(CCn1ccc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc21)S(C)(=O)=O | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL30315 | 202338 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 510 | 6 | 0 | 6 | 3.3 | CN(CCn1ccc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc21)S(C)(=O)=O | 10.1016/s0960-894x(02)00159-2 | |||
| 44280013 | 203036 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 461 | 5 | 1 | 5 | 3.9 | CC(=O)NCCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL30667 | 203036 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 461 | 5 | 1 | 5 | 3.9 | CC(=O)NCCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00159-2 | |||
| 56950590 | 156715 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 545 | 8 | 2 | 4 | 4.3 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccccc1OC(F)(F)F | 10.1021/jm201287w | |||
| CHEMBL2035014 | 156715 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 545 | 8 | 2 | 4 | 4.3 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccccc1OC(F)(F)F | 10.1021/jm201287w | |||
| 56950591 | 156716 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 537 | 8 | 2 | 3 | 5.1 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccccc1-c1ccccc1 | 10.1021/jm201287w | |||
| CHEMBL2035015 | 156716 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 537 | 8 | 2 | 3 | 5.1 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccccc1-c1ccccc1 | 10.1021/jm201287w | |||
| 44456003 | 197939 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 508 | 8 | 3 | 5 | 2.4 | CNC(=O)c1ccc([C@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)o1 | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL271057 | 197939 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 508 | 8 | 3 | 5 | 2.4 | CNC(=O)c1ccc([C@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)o1 | 10.1016/j.bmcl.2007.11.008 | |||
| 44581682 | 372670 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 452 | 8 | 0 | 8 | 3.5 | COc1ccc(S(=O)(=O)N(Cc2noc(-c3ccccc3)n2)c2ccc(OC)nc2)cc1 | 10.1016/j.bmcl.2008.11.018 | |||
| CHEMBL514287 | 372670 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 452 | 8 | 0 | 8 | 3.5 | COc1ccc(S(=O)(=O)N(Cc2noc(-c3ccccc3)n2)c2ccc(OC)nc2)cc1 | 10.1016/j.bmcl.2008.11.018 | |||
| 44581647 | 372806 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 438 | 7 | 0 | 7 | 4.0 | COc1ccc(N(Cc2nc(-c3ccccc3)cs2)S(=O)(=O)c2ccccn2)cn1 | 10.1016/j.bmcl.2008.11.018 | |||
| CHEMBL515384 | 372806 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 438 | 7 | 0 | 7 | 4.0 | COc1ccc(N(Cc2nc(-c3ccccc3)cs2)S(=O)(=O)c2ccccn2)cn1 | 10.1016/j.bmcl.2008.11.018 | |||
| 2213 | 1072 | 37 | None | -22 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm060073e | |||
| 3008 | 1072 | 37 | None | -22 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm060073e | |||
| 5311010 | 1072 | 37 | None | -22 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm060073e | |||
| 68613 | 1072 | 37 | None | -22 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm060073e | |||
| CHEMBL378642 | 1072 | 37 | None | -22 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm060073e | |||
| CHEMBL382301 | 1072 | 37 | None | -22 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm060073e | |||
| DB09059 | 1072 | 37 | None | -22 | 5 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm060073e | |||
| 11591519 | 144344 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 505 | 7 | 2 | 4 | 3.8 | COc1ccc([C@@H](C(=O)NC(C)(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| 11649100 | 144344 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 505 | 7 | 2 | 4 | 3.8 | COc1ccc([C@@H](C(=O)NC(C)(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| CHEMBL197822 | 144344 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 505 | 7 | 2 | 4 | 3.8 | COc1ccc([C@@H](C(=O)NC(C)(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| CHEMBL372128 | 144344 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 505 | 7 | 2 | 4 | 3.8 | COc1ccc([C@@H](C(=O)NC(C)(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| 2213 | 1072 | 37 | None | -20 | 5 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm060073e | |||
| 3008 | 1072 | 37 | None | -20 | 5 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm060073e | |||
| 5311010 | 1072 | 37 | None | -20 | 5 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm060073e | |||
| 68613 | 1072 | 37 | None | -20 | 5 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm060073e | |||
| CHEMBL378642 | 1072 | 37 | None | -20 | 5 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm060073e | |||
| CHEMBL382301 | 1072 | 37 | None | -20 | 5 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm060073e | |||
| DB09059 | 1072 | 37 | None | -20 | 5 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm060073e | |||
| 44274659 | 196309 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 650 | 10 | 3 | 7 | 2.2 | NC(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)CN1C(=O)C(NC(=O)CN2CCOCC2)N=C(c2ccccc2)c2ccccc21 | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL25942 | 196309 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 650 | 10 | 3 | 7 | 2.2 | NC(=O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)CN1C(=O)C(NC(=O)CN2CCOCC2)N=C(c2ccccc2)c2ccccc21 | 10.1016/s0960-894x(01)00202-5 | |||
| 44275210 | 195410 | 0 | None | 4 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 491 | 5 | 0 | 5 | 3.8 | CC(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc2)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL25502 | 195410 | 0 | None | 4 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 491 | 5 | 0 | 5 | 3.8 | CC(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc2)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| 47177173 | 329382 | 0 | None | -8 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 377 | 1 | 0 | 1 | 4.3 | O=C(c1ccc(I)cc1)N1CCCCc2ccccc21 | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL4213812 | 329382 | 0 | None | -8 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 377 | 1 | 0 | 1 | 4.3 | O=C(c1ccc(I)cc1)N1CCCCc2ccccc21 | 10.1021/acs.jmedchem.8b00697 | |||
| 2213 | 1072 | 37 | None | -22 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2008.11.064 | |||
| 3008 | 1072 | 37 | None | -22 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2008.11.064 | |||
| 5311010 | 1072 | 37 | None | -22 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2008.11.064 | |||
| 68613 | 1072 | 37 | None | -22 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2008.11.064 | |||
| CHEMBL378642 | 1072 | 37 | None | -22 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2008.11.064 | |||
| CHEMBL382301 | 1072 | 37 | None | -22 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2008.11.064 | |||
| DB09059 | 1072 | 37 | None | -22 | 5 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1016/j.bmcl.2008.11.064 | |||
| 44279752 | 213320 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 564 | 5 | 0 | 6 | 4.4 | Cc1c(C)n(C[C@H]2CCCN2S(C)(=O)=O)c2ccc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc12 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL30865 | 213320 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 564 | 5 | 0 | 6 | 4.4 | Cc1c(C)n(C[C@H]2CCCN2S(C)(=O)=O)c2ccc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc12 | 10.1016/s0960-894x(02)00159-2 | |||
| 44279348 | 216888 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 376 | 2 | 0 | 4 | 4.2 | O=C(c1ccc2ccoc2c1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL31691 | 216888 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 376 | 2 | 0 | 4 | 4.2 | O=C(c1ccc2ccoc2c1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| 44279454 | 217060 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 460 | 5 | 1 | 5 | 3.5 | CC(=O)NCCn1ccc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc21 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL31823 | 217060 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 460 | 5 | 1 | 5 | 3.5 | CC(=O)NCCn1ccc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc21 | 10.1016/s0960-894x(02)00159-2 | |||
| 44279519 | 220145 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 511 | 6 | 0 | 7 | 2.7 | CN(CCn1cnc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc21)S(C)(=O)=O | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL32567 | 220145 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 511 | 6 | 0 | 7 | 2.7 | CN(CCn1cnc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc21)S(C)(=O)=O | 10.1016/s0960-894x(02)00159-2 | |||
| 2253 | 4548 | 22 | None | -5 | 6 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 586 | 7 | 0 | 7 | 4.4 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)Cc1ccc[n+](c1C)[O-] | 10.1021/jm9800797 | |||
| 5311202 | 4548 | 22 | None | -5 | 6 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 586 | 7 | 0 | 7 | 4.4 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)Cc1ccc[n+](c1C)[O-] | 10.1021/jm9800797 | |||
| CHEMBL306645 | 4548 | 22 | None | -5 | 6 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 586 | 7 | 0 | 7 | 4.4 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)Cc1ccc[n+](c1C)[O-] | 10.1021/jm9800797 | |||
| 10579886 | 213336 | 0 | None | -4 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 632 | 7 | 0 | 7 | 5.2 | COc1cc(OC2CCN(Cc3c(C)cc(C)[n+]([O-])c3C)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL308673 | 213336 | 0 | None | -4 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 632 | 7 | 0 | 7 | 5.2 | COc1cc(OC2CCN(Cc3c(C)cc(C)[n+]([O-])c3C)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 11340891 | 6755 | 33 | None | 891 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 10.1016/j.bmcl.2007.11.008 | |||
| 8403 | 6755 | 33 | None | 891 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL429736 | 6755 | 33 | None | 891 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 10.1016/j.bmcl.2007.11.008 | |||
| DB11818 | 6755 | 33 | None | 891 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 10.1016/j.bmcl.2007.11.008 | |||
| 135530014 | 160549 | 0 | None | 151 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 526 | 9 | 3 | 6 | 2.9 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(CCCO)cc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm050645f | |||
| CHEMBL2113179 | 160549 | 0 | None | 151 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 526 | 9 | 3 | 6 | 2.9 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(CCCO)cc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm050645f | |||
| 10651439 | 202957 | 0 | None | 2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 614 | 7 | 0 | 7 | 5.1 | COc1cc(OC2CCN(Cc3c(C)cc(C)[n+]([O-])c3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL306010 | 202957 | 0 | None | 2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 614 | 7 | 0 | 7 | 5.1 | COc1cc(OC2CCN(Cc3c(C)cc(C)[n+]([O-])c3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 44297632 | 202117 | 0 | None | 57 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 780 | 6 | 3 | 6 | 2.9 | CC[C@@H](C)[C@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)N2CCN(CC2)C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00169a001 | |||
| CHEMBL301708 | 202117 | 0 | None | 57 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 780 | 6 | 3 | 6 | 2.9 | CC[C@@H](C)[C@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)N2CCN(CC2)C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00169a001 | |||
| 10555563 | 202203 | 0 | None | -4 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 600 | 7 | 0 | 7 | 4.8 | COc1cc(OC2CCN(Cc3c(C)cc[n+]([O-])c3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL302297 | 202203 | 0 | None | -4 | 2 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 600 | 7 | 0 | 7 | 4.8 | COc1cc(OC2CCN(Cc3c(C)cc[n+]([O-])c3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 15840433 | 194848 | 0 | None | 1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 448 | 5 | 0 | 4 | 4.3 | O=C(Cc1ccccc1OCC(F)(F)F)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL25120 | 194848 | 0 | None | 1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 448 | 5 | 0 | 4 | 4.3 | O=C(Cc1ccccc1OCC(F)(F)F)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL435021 | 488610 | 4 | None | -1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 780 | 6 | 4 | 7 | 2.0 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CNCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 2252 | 4546 | 39 | None | -1 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1021/jm00023a002 | |||
| 6918320 | 4546 | 39 | None | -1 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1021/jm00023a002 | |||
| CHEMBL24781 | 4546 | 39 | None | -1 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1021/jm00023a002 | |||
| 135493119 | 160559 | 0 | None | -4 | 3 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 569 | 11 | 2 | 7 | 3.3 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113201 | 160559 | 0 | None | -4 | 3 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 569 | 11 | 2 | 7 | 3.3 | CN(C)CCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| 2252 | 4546 | 39 | None | -1 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1021/jm901812z | |||
| 6918320 | 4546 | 39 | None | -1 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1021/jm901812z | |||
| CHEMBL24781 | 4546 | 39 | None | -1 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1021/jm901812z | |||
| CHEMBL435021 | 488610 | 4 | None | -1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 780 | 6 | 4 | 7 | 2.0 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CNCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 2252 | 4546 | 39 | None | -1 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1021/jm9800797 | |||
| 6918320 | 4546 | 39 | None | -1 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1021/jm9800797 | |||
| CHEMBL24781 | 4546 | 39 | None | -1 | 5 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1021/jm9800797 | |||
| 10651225 | 213109 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 600 | 6 | 0 | 7 | 5.5 | COc1cc(OC2CCN(C3CCc4ncccc43)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL308460 | 213109 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 600 | 6 | 0 | 7 | 5.5 | COc1cc(OC2CCN(C3CCc4ncccc43)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 44297516 | 316841 | 0 | None | -19 | 3 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 1315 | 37 | 15 | 16 | -2.2 | CN(C(=O)Cc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | 10.1021/jm00038a013 | |||
| CHEMBL412192 | 316841 | 0 | None | -19 | 3 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 1315 | 37 | 15 | 16 | -2.2 | CN(C(=O)Cc1ccc(N=[N+]=[N-])cc1)[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O | 10.1021/jm00038a013 | |||
| 2253 | 4548 | 22 | None | -5 | 6 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 586 | 7 | 0 | 7 | 4.4 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)Cc1ccc[n+](c1C)[O-] | 10.1021/jm901812z | |||
| 5311202 | 4548 | 22 | None | -5 | 6 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 586 | 7 | 0 | 7 | 4.4 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)Cc1ccc[n+](c1C)[O-] | 10.1021/jm901812z | |||
| CHEMBL306645 | 4548 | 22 | None | -5 | 6 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 586 | 7 | 0 | 7 | 4.4 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)Cc1ccc[n+](c1C)[O-] | 10.1021/jm901812z | |||
| 16109440 | 317156 | 0 | None | -162 | 4 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 997 | 16 | 11 | 14 | -2.3 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| CHEMBL412973 | 317156 | 0 | None | -162 | 4 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 997 | 16 | 11 | 14 | -2.3 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| 145970269 | 328552 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 475 | 5 | 3 | 6 | 2.5 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)NCC(=O)N(C)C | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL4203314 | 328552 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 475 | 5 | 3 | 6 | 2.5 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)NCC(=O)N(C)C | 10.1021/acs.jmedchem.8b00697 | |||
| 54584476 | 125111 | 0 | None | -32 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 630 | 8 | 1 | 10 | 2.3 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3cccnc3OC)(N3C[C@H](O)C[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)c(OC)c1 | 10.1016/j.bmcl.2011.03.012 | |||
| CHEMBL1779400 | 125111 | 0 | None | -32 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 630 | 8 | 1 | 10 | 2.3 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3cccnc3OC)(N3C[C@H](O)C[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)c(OC)c1 | 10.1016/j.bmcl.2011.03.012 | |||
| 16109444 | 316992 | 0 | None | -537 | 4 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 1037 | 16 | 11 | 14 | -1.3 | NCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm060928n | |||
| CHEMBL412742 | 316992 | 0 | None | -537 | 4 | Rat | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 1037 | 16 | 11 | 14 | -1.3 | NCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm060928n | |||
| 44335300 | 18983 | 0 | None | -5 | 2 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 486 | 6 | 0 | 5 | 5.6 | COc1cc(OC(C)c2ccccc2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL102994 | 18983 | 0 | None | -5 | 2 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 486 | 6 | 0 | 5 | 5.6 | COc1cc(OC(C)c2ccccc2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| 151171 | 2408 | 36 | None | -19 | 5 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 498 | 4 | 2 | 3 | 6.5 | Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 | 10.1021/acs.jmedchem.8b00697 | |||
| 2203 | 2408 | 36 | None | -19 | 5 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 498 | 4 | 2 | 3 | 6.5 | Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 | 10.1021/acs.jmedchem.8b00697 | |||
| 732 | 2408 | 36 | None | -19 | 5 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 498 | 4 | 2 | 3 | 6.5 | Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL1755 | 2408 | 36 | None | -19 | 5 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 498 | 4 | 2 | 3 | 6.5 | Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 | 10.1021/acs.jmedchem.8b00697 | |||
| DB00872 | 2408 | 36 | None | -19 | 5 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 498 | 4 | 2 | 3 | 6.5 | Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 | 10.1021/acs.jmedchem.8b00697 | |||
| 135399794 | 160553 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 506 | 8 | 2 | 6 | 3.5 | CCOc1ccc(S(=O)(=O)N(c2ccc(C)cc2)C(C)C(=O)N/N=C2\C(=O)Nc3ccccc32)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113194 | 160553 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 506 | 8 | 2 | 6 | 3.5 | CCOc1ccc(S(=O)(=O)N(c2ccc(C)cc2)C(C)C(=O)N/N=C2\C(=O)Nc3ccccc32)cc1 | 10.1021/jm050645f | |||
| 54585429 | 125115 | 0 | None | -7 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 661 | 9 | 1 | 12 | 1.7 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3cnc(OC)nc3OC)(N3C[C@H](O)C[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)c(OC)c1 | 10.1016/j.bmcl.2011.03.012 | |||
| CHEMBL1779404 | 125115 | 0 | None | -7 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 661 | 9 | 1 | 12 | 1.7 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3cnc(OC)nc3OC)(N3C[C@H](O)C[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)c(OC)c1 | 10.1016/j.bmcl.2011.03.012 | |||
| 54586391 | 125116 | 0 | None | -54 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 696 | 10 | 0 | 9 | 4.5 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3ccc(CN4CCCC4)cc3OC)(N3CCC[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)c(OC)c1 | 10.1016/j.bmcl.2011.03.012 | |||
| CHEMBL1779405 | 125116 | 0 | None | -54 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 696 | 10 | 0 | 9 | 4.5 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3ccc(CN4CCCC4)cc3OC)(N3CCC[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)c(OC)c1 | 10.1016/j.bmcl.2011.03.012 | |||
| 999998 | 277908 | 10 | None | -1 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 420 | 5 | 0 | 3 | 3.8 | Cc1ccc(N(CC(=O)N2CCc3ccccc3C2)S(=O)(=O)c2ccccc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL381433 | 277908 | 10 | None | -1 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 420 | 5 | 0 | 3 | 3.8 | Cc1ccc(N(CC(=O)N2CCc3ccccc3C2)S(=O)(=O)c2ccccc2)cc1 | 10.1021/jm050645f | |||
| 44316235 | 316115 | 0 | None | -7 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 1011 | 16 | 12 | 14 | -3.6 | C[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| CHEMBL411148 | 316115 | 0 | None | -7 | 4 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 1011 | 16 | 12 | 14 | -3.6 | C[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| 44316241 | 197234 | 0 | None | -12022 | 8 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 1053 | 18 | 13 | 14 | -2.4 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| 44419029 | 197234 | 0 | None | -12022 | 8 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 1053 | 18 | 13 | 14 | -2.4 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| CHEMBL265859 | 197234 | 0 | None | -12022 | 8 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 1053 | 18 | 13 | 14 | -2.4 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| CHEMBL268306 | 197234 | 0 | None | -12022 | 8 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 1053 | 18 | 13 | 14 | -2.4 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| CHEMBL2369834 | 477594 | 0 | None | -37 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 1040 | 18 | 13 | 15 | -4.3 | NCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| CHEMBL2372926 | 485914 | 0 | None | 5 | 2 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 784 | 8 | 2 | 7 | 3.5 | CCOc1ccc(C[C@H]2NC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3ccccc3)N(C)C(=O)[C@@H]3CCCCN3C(=O)[C@H]3CCCCN3C(=O)[C@H]([C@@H](C)CC)NC2=O)cc1 | 10.1021/jm00169a001 | |||
| CHEMBL2372928 | 485916 | 0 | None | 10 | 2 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 782 | 9 | 5 | 7 | 2.4 | CC[C@@H](C)[C@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCN)NC(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00169a001 | |||
| CHEMBL339493 | 487019 | 0 | None | None | None | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 664 | 4 | 2 | 6 | 1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](C)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00169a001 | |||
| 135644174 | 144033 | 4 | None | -8 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 457 | 7 | 2 | 5 | 3.8 | C/C(=N\NC(=O)CN(c1cccc(Cl)c1)S(=O)(=O)c1ccccc1)c1ccccc1O | 10.1021/jm050645f | |||
| CHEMBL196816 | 144033 | 4 | None | -8 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 457 | 7 | 2 | 5 | 3.8 | C/C(=N\NC(=O)CN(c1cccc(Cl)c1)S(=O)(=O)c1ccccc1)c1ccccc1O | 10.1021/jm050645f | |||
| 71451752 | 163806 | 0 | None | -9 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 1295 | 30 | 4 | 17 | 7.6 | CCN(CC)c1ccc2c(-c3ccc(S(=O)(=O)NCCOCCOCCOCCn4cc(CNC(=O)CCC(=O)NC5CCCN(C(=O)c6ccc(NC(=O)c7ccccc7C)cc6)c6ccccc65)nn4)cc3S(=O)(=O)[O-])c3ccc(=[N+](CC)CC)cc-3oc2c1 | 10.1021/jm3006146 | |||
| CHEMBL2172293 | 163806 | 0 | None | -9 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 1295 | 30 | 4 | 17 | 7.6 | CCN(CC)c1ccc2c(-c3ccc(S(=O)(=O)NCCOCCOCCOCCn4cc(CNC(=O)CCC(=O)NC5CCCN(C(=O)c6ccc(NC(=O)c7ccccc7C)cc6)c6ccccc65)nn4)cc3S(=O)(=O)[O-])c3ccc(=[N+](CC)CC)cc-3oc2c1 | 10.1021/jm3006146 | |||
| 5311065 | 484177 | 30 | None | -4 | 8 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm030611c | |||
| 817 | 484177 | 30 | None | -4 | 8 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm030611c | |||
| CHEMBL1429 | 484177 | 30 | None | -4 | 8 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm030611c | |||
| DB00035 | 484177 | 30 | None | -4 | 8 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm030611c | |||
| 11627894 | 142520 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 529 | 7 | 2 | 3 | 4.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccc(C(F)(F)F)cc1 | 10.1021/jm050557v | |||
| 11663715 | 142520 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 529 | 7 | 2 | 3 | 4.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccc(C(F)(F)F)cc1 | 10.1021/jm050557v | |||
| CHEMBL194233 | 142520 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 529 | 7 | 2 | 3 | 4.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccc(C(F)(F)F)cc1 | 10.1021/jm050557v | |||
| CHEMBL198329 | 142520 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 529 | 7 | 2 | 3 | 4.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccc(C(F)(F)F)cc1 | 10.1021/jm050557v | |||
| 11385982 | 142544 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 475 | 6 | 2 | 3 | 3.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccccc1 | 10.1021/jm050557v | |||
| 11408910 | 142544 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 475 | 6 | 2 | 3 | 3.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccccc1 | 10.1021/jm050557v | |||
| CHEMBL194374 | 142544 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 475 | 6 | 2 | 3 | 3.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccccc1 | 10.1021/jm050557v | |||
| CHEMBL198328 | 142544 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 475 | 6 | 2 | 3 | 3.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccccc1 | 10.1021/jm050557v | |||
| 11577662 | 144024 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 559 | 7 | 2 | 4 | 4.7 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccc(OC(F)(F)F)cc1 | 10.1021/jm050557v | |||
| 11606502 | 144024 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 559 | 7 | 2 | 4 | 4.7 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccc(OC(F)(F)F)cc1 | 10.1021/jm050557v | |||
| CHEMBL196780 | 144024 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 559 | 7 | 2 | 4 | 4.7 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccc(OC(F)(F)F)cc1 | 10.1021/jm050557v | |||
| CHEMBL372516 | 144024 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 559 | 7 | 2 | 4 | 4.7 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccc(OC(F)(F)F)cc1 | 10.1021/jm050557v | |||
| 56949908 | 156989 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 460 | 6 | 1 | 4 | 2.4 | Cc1ccc([C@H](C(=O)N(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC2CC2)cn1 | 10.1021/jm201287w | |||
| CHEMBL2037494 | 156989 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 460 | 6 | 1 | 4 | 2.4 | Cc1ccc([C@H](C(=O)N(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC2CC2)cn1 | 10.1021/jm201287w | |||
| 56949909 | 156990 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 502 | 6 | 1 | 5 | 2.2 | Cc1ccc([C@H](C(=O)N2CCOCC2)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC2CC2)cn1 | 10.1021/jm201287w | |||
| CHEMBL2037495 | 156990 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 502 | 6 | 1 | 5 | 2.2 | Cc1ccc([C@H](C(=O)N2CCOCC2)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC2CC2)cn1 | 10.1021/jm201287w | |||
| 121301508 | 350186 | 8 | None | -8 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 542 | 7 | 2 | 9 | 3.6 | C[C@H](O)c1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nn1-c1cccc(Cl)c1 | 10.6019/CHEMBL5463729 | |||
| CHEMBL4594444 | 350186 | 8 | None | -8 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 542 | 7 | 2 | 9 | 3.6 | C[C@H](O)c1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nn1-c1cccc(Cl)c1 | 10.6019/CHEMBL5463729 | |||
| DB16279 | 350186 | 8 | None | -8 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 542 | 7 | 2 | 9 | 3.6 | C[C@H](O)c1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nn1-c1cccc(Cl)c1 | 10.6019/CHEMBL5463729 | |||
| 10627414 | 468768 | 0 | None | 5 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 600 | 7 | 0 | 7 | 4.8 | COc1cc(OC2CCN(Cc3c[n+]([O-])c(C)cc3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL68199 | 468768 | 0 | None | 5 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 600 | 7 | 0 | 7 | 4.8 | COc1cc(OC2CCN(Cc3c[n+]([O-])c(C)cc3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 10531717 | 203009 | 0 | None | -4 | 2 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 604 | 7 | 0 | 7 | 4.6 | COc1cc(OC2CCN(Cc3ccc[n+]([O-])c3C)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL306416 | 203009 | 0 | None | -4 | 2 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 604 | 7 | 0 | 7 | 4.6 | COc1cc(OC2CCN(Cc3ccc[n+]([O-])c3C)CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL2112249 | 485097 | 2 | None | -8 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 766 | 6 | 4 | 7 | 2.6 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 121301508 | 350186 | 8 | None | -8 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 542 | 7 | 2 | 9 | 3.6 | C[C@H](O)c1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nn1-c1cccc(Cl)c1 | 10.6019/CHEMBL5463729 | |||
| CHEMBL4594444 | 350186 | 8 | None | -8 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 542 | 7 | 2 | 9 | 3.6 | C[C@H](O)c1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nn1-c1cccc(Cl)c1 | 10.6019/CHEMBL5463729 | |||
| DB16279 | 350186 | 8 | None | -8 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 542 | 7 | 2 | 9 | 3.6 | C[C@H](O)c1nc(Cn2nc(-c3ccc(Cl)cc3)n(C[C@H](O)C(F)(F)F)c2=O)nn1-c1cccc(Cl)c1 | 10.6019/CHEMBL5463729 | |||
| 10483105 | 174420 | 1 | None | 34 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 568 | 10 | 2 | 7 | 1.8 | CN[C@@H](CCS(C)(=O)=O)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCN(c3ccccc3C)CC1)C2(C)C | 10.1016/j.bmcl.2012.10.116 | |||
| CHEMBL2391300 | 174420 | 1 | None | 34 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 568 | 10 | 2 | 7 | 1.8 | CN[C@@H](CCS(C)(=O)=O)C(=O)N[C@H]1C[C@H]2CC[C@]1(CS(=O)(=O)N1CCN(c3ccccc3C)CC1)C2(C)C | 10.1016/j.bmcl.2012.10.116 | |||
| 10722297 | 468477 | 0 | None | 5 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 600 | 7 | 0 | 7 | 4.8 | COc1cc(OC2CCN(Cc3ccc(C)[n+]([O-])c3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL65949 | 468477 | 0 | None | 5 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 600 | 7 | 0 | 7 | 4.8 | COc1cc(OC2CCN(Cc3ccc(C)[n+]([O-])c3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL54443 | 489222 | 0 | None | 70 | 2 | Rat | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 756 | 6 | 6 | 8 | 0.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCN2C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]2CCCCN2C(=O)[C@@H]2CCNCN2C1=O | 10.1021/jm00169a001 | |||
| 10005688 | 19410 | 0 | None | 2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 487 | 6 | 0 | 6 | 5.0 | COc1cc(OC(C)c2cccnc2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL105406 | 19410 | 0 | None | 2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 487 | 6 | 0 | 6 | 5.0 | COc1cc(OC(C)c2cccnc2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL3814395 | 487602 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 1020 | 18 | 12 | 15 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | |||
| 10746141 | 468478 | 0 | None | 2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 600 | 6 | 0 | 7 | 4.1 | COc1cc(OC2CCN(C(=O)c3ccc[n+]([O-])c3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL65950 | 468478 | 0 | None | 2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 600 | 6 | 0 | 7 | 4.1 | COc1cc(OC2CCN(C(=O)c3ccc[n+]([O-])c3C)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 57519947 | 155340 | 0 | None | 91 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 707 | 9 | 0 | 6 | 4.3 | CS(=O)(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)CCc5ccccc54)CC3)c(OC/C=C\I)c2)CC1 | 10.1016/j.bmc.2012.02.019 | |||
| CHEMBL2017868 | 155340 | 0 | None | 91 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 707 | 9 | 0 | 6 | 4.3 | CS(=O)(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)CCc5ccccc54)CC3)c(OC/C=C\I)c2)CC1 | 10.1016/j.bmc.2012.02.019 | |||
| CHEMBL300103 | 486408 | 0 | None | 81 | 2 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 741 | 6 | 3 | 7 | 1.8 | CC[C@H](C)[C@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCNCN2C1=O | 10.1021/jm00169a001 | |||
| 52947410 | 40894 | 0 | None | 1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 390 | 4 | 0 | 6 | 3.9 | CO/N=C1/C[C@H](c2nc(C)no2)N(C(=O)c2ccc(-c3ccccc3C)cc2)C1 | 10.1021/jm901812z | |||
| CHEMBL1254210 | 40894 | 0 | None | 1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 390 | 4 | 0 | 6 | 3.9 | CO/N=C1/C[C@H](c2nc(C)no2)N(C(=O)c2ccc(-c3ccccc3C)cc2)C1 | 10.1021/jm901812z | |||
| 145962220 | 317117 | 0 | None | 33 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 1095 | 17 | 11 | 14 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2cccc(c2)CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2018.03.019 | |||
| CHEMBL4129142 | 317117 | 0 | None | 33 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 1095 | 17 | 11 | 14 | -0.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSCc2cccc(c2)CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2018.03.019 | |||
| 44279980 | 199367 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 621 | 6 | 1 | 7 | 4.4 | Cn1c(CNC(=O)Cn2cc(C(F)(F)F)ccc2=O)cc2ccc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc21 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL281106 | 199367 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 621 | 6 | 1 | 7 | 4.4 | Cn1c(CNC(=O)Cn2cc(C(F)(F)F)ccc2=O)cc2ccc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc21 | 10.1016/s0960-894x(02)00160-9 | |||
| 11612607 | 142825 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 475 | 7 | 2 | 3 | 3.7 | Cc1ccc([C@@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| 11691416 | 142825 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 475 | 7 | 2 | 3 | 3.7 | Cc1ccc([C@@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| CHEMBL194922 | 142825 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 475 | 7 | 2 | 3 | 3.7 | Cc1ccc([C@@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| CHEMBL555148 | 142825 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 475 | 7 | 2 | 3 | 3.7 | Cc1ccc([C@@H](C(=O)NC(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)cc1 | 10.1021/jm050557v | |||
| 11363194 | 198471 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 461 | 7 | 2 | 3 | 3.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccccc1 | 10.1021/jm050557v | |||
| 11641200 | 198471 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 461 | 7 | 2 | 3 | 3.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccccc1 | 10.1021/jm050557v | |||
| CHEMBL273988 | 198471 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 461 | 7 | 2 | 3 | 3.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccccc1 | 10.1021/jm050557v | |||
| CHEMBL382518 | 198471 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 461 | 7 | 2 | 3 | 3.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccccc1 | 10.1021/jm050557v | |||
| 11519251 | 331145 | 0 | None | 3 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 521 | 9 | 1 | 5 | 3.4 | CCOc1ccc(S(=O)(=O)N(CC(=O)N2Cc3ccccc3CC2CC(N)=O)c2ccc(C)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL427190 | 331145 | 0 | None | 3 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 521 | 9 | 1 | 5 | 3.4 | CCOc1ccc(S(=O)(=O)N(CC(=O)N2Cc3ccccc3CC2CC(N)=O)c2ccc(C)cc2)cc1 | 10.1021/jm050645f | |||
| 44274621 | 197021 | 0 | None | None | None | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 601 | 9 | 3 | 6 | 2.3 | CS(=O)(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL26398 | 197021 | 0 | None | None | None | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 601 | 9 | 3 | 6 | 2.3 | CS(=O)(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| 135506374 | 275287 | 21 | None | -1 | 3 | Mouse | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.7b00965 | |||
| CHEMBL3763342 | 275287 | 21 | None | -1 | 3 | Mouse | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.7b00965 | |||
| 11692335 | 144207 | 0 | None | 3 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 537 | 10 | 1 | 6 | 3.1 | CCOc1ccc(S(=O)(=O)N(CC(=O)N2Cc3ccccc3CC2CC(N)=O)c2ccc(OC)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL197378 | 144207 | 0 | None | 3 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 537 | 10 | 1 | 6 | 3.1 | CCOc1ccc(S(=O)(=O)N(CC(=O)N2Cc3ccccc3CC2CC(N)=O)c2ccc(OC)cc2)cc1 | 10.1021/jm050645f | |||
| 44275244 | 195608 | 0 | None | -2 | 2 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 424 | 6 | 0 | 5 | 3.8 | COc1ccc(CCC(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)c(OC)c1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL25611 | 195608 | 0 | None | -2 | 2 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 424 | 6 | 0 | 5 | 3.8 | COc1ccc(CCC(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)c(OC)c1 | 10.1016/s0960-894x(99)00181-x | |||
| 10650710 | 468577 | 0 | None | -3 | 2 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 570 | 7 | 0 | 7 | 5.5 | COc1cc(OC2CCN(C(C)c3cccnc3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL66749 | 468577 | 0 | None | -3 | 2 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 570 | 7 | 0 | 7 | 5.5 | COc1cc(OC2CCN(C(C)c3cccnc3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 9981665 | 232117 | 5 | None | -1 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 459 | 5 | 2 | 4 | 3.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CC(=O)O)C2 | 10.1021/jm901812z | |||
| CHEMBL341339 | 232117 | 5 | None | -1 | 6 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 459 | 5 | 2 | 4 | 3.4 | CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N1CCC3(C=Cc4ccccc43)CC1)[C@@](O)(CC(=O)O)C2 | 10.1021/jm901812z | |||
| 19691009 | 217054 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 535 | 6 | 0 | 6 | 4.5 | COc1cc(OC(C)C2CCN(C(C)=O)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL318174 | 217054 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 535 | 6 | 0 | 6 | 4.5 | COc1cc(OC(C)C2CCN(C(C)=O)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL2372251 | 477727 | 0 | None | None | None | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 1005 | 17 | 11 | 14 | -1.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CC(C)(C)SS[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm990090m | |||
| 16109445 | 274649 | 0 | None | -213 | 4 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 1011 | 17 | 11 | 14 | -1.9 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| CHEMBL375188 | 274649 | 0 | None | -213 | 4 | Rat | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 1011 | 17 | 11 | 14 | -1.9 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| 16109438 | 196913 | 0 | None | -181 | 4 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 1051 | 17 | 11 | 14 | -1.0 | NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm060928n | |||
| CHEMBL263090 | 196913 | 0 | None | -181 | 4 | Rat | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 1051 | 17 | 11 | 14 | -1.0 | NCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm060928n | |||
| 45483204 | 404679 | 0 | None | -19 | 5 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 619 | 11 | 1 | 7 | 4.6 | COc1ccc(S(=O)(=O)N2c3ccccc3CCC2CCS(=O)(=O)N2CCC(NCC3CCCCC3)CC2)c(OC)c1 | 10.1016/j.bmcl.2009.09.050 | |||
| CHEMBL572709 | 404679 | 0 | None | -19 | 5 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 619 | 11 | 1 | 7 | 4.6 | COc1ccc(S(=O)(=O)N2c3ccccc3CCC2CCS(=O)(=O)N2CCC(NCC3CCCCC3)CC2)c(OC)c1 | 10.1016/j.bmcl.2009.09.050 | |||
| 44316236 | 470360 | 0 | None | -24 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 997 | 16 | 12 | 14 | -4.0 | NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H]1CCCN1C(=O)[C@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)NCC(=O)N[C@H](CC(N)=O)C(=O)N1 | 10.1021/jm030611c | |||
| CHEMBL80877 | 470360 | 0 | None | -24 | 4 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 997 | 16 | 12 | 14 | -4.0 | NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H]1CCCN1C(=O)[C@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)NCC(=O)N[C@H](CC(N)=O)C(=O)N1 | 10.1021/jm030611c | |||
| 44243143 | 40903 | 0 | None | 8 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 372 | 5 | 0 | 6 | 4.3 | COc1ccc(-n2c(C)nnc2-c2ccc(-c3ccccc3OC)cc2)cn1 | 10.1021/jm901812z | |||
| CHEMBL1254297 | 40903 | 0 | None | 8 | 3 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 372 | 5 | 0 | 6 | 4.3 | COc1ccc(-n2c(C)nnc2-c2ccc(-c3ccccc3OC)cc2)cn1 | 10.1021/jm901812z | |||
| 44334971 | 18948 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 500 | 7 | 0 | 5 | 6.0 | CCC(Oc1ccc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)c(OC)c1)c1ccccc1 | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL102762 | 18948 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 500 | 7 | 0 | 5 | 6.0 | CCC(Oc1ccc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)c(OC)c1)c1ccccc1 | 10.1016/s0960-894x(98)00568-x | |||
| 135506374 | 275287 | 21 | None | -3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1016/j.ejmech.2015.11.050 | |||
| CHEMBL3763342 | 275287 | 21 | None | -3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1016/j.ejmech.2015.11.050 | |||
| 135506374 | 275287 | 21 | None | -3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.7b00965 | |||
| CHEMBL3763342 | 275287 | 21 | None | -3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.7b00965 | |||
| 135506374 | 275287 | 21 | None | -3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL3763342 | 275287 | 21 | None | -3 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.8b00697 | |||
| 16109437 | 175275 | 0 | None | -309 | 4 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 1065 | 18 | 11 | 14 | -0.6 | NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm060928n | |||
| CHEMBL221485 | 175275 | 0 | None | -309 | 4 | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 1065 | 18 | 11 | 14 | -0.6 | NCCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC2CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | 10.1021/jm060928n | |||
| 10510242 | 238988 | 0 | None | None | None | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1023 | 17 | 11 | 15 | -1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm9607156 | |||
| 11083629 | 238988 | 0 | None | None | None | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1023 | 17 | 11 | 15 | -1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm9607156 | |||
| CHEMBL352836 | 238988 | 0 | None | None | None | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1023 | 17 | 11 | 15 | -1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm9607156 | |||
| CHEMBL353396 | 238988 | 0 | None | None | None | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1023 | 17 | 11 | 15 | -1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm9607156 | |||
| 15840433 | 194848 | 0 | None | -1 | 2 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 448 | 5 | 0 | 4 | 4.3 | O=C(Cc1ccccc1OCC(F)(F)F)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL25120 | 194848 | 0 | None | -1 | 2 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 448 | 5 | 0 | 4 | 4.3 | O=C(Cc1ccccc1OCC(F)(F)F)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL1790937 | 484815 | 0 | None | 2 | 2 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 755 | 6 | 5 | 7 | 1.9 | CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| CHEMBL338308 | 487001 | 0 | None | 4 | 2 | Rat | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 742 | 9 | 4 | 8 | 1.5 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@H](CCCN)NC(=O)[C@H]2CCC=NN2C1=O | 10.1021/jm00099a019 | |||
| 11257380 | 352525 | 0 | None | 64 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 376 | 4 | 0 | 7 | 3.6 | COc1ccc(-n2c(C)nnc2-c2cnc(-c3ccc(F)cc3C)cn2)cn1 | 10.1021/jm901812z | |||
| CHEMBL467378 | 352525 | 0 | None | 64 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 376 | 4 | 0 | 7 | 3.6 | COc1ccc(-n2c(C)nnc2-c2cnc(-c3ccc(F)cc3C)cn2)cn1 | 10.1021/jm901812z | |||
| 146681949 | 8624 | 35 | None | -5 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1016/j.bmc.2018.03.019 | |||
| 2168 | 8624 | 35 | None | -5 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1016/j.bmc.2018.03.019 | |||
| 2810 | 8624 | 35 | None | -5 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1016/j.bmc.2018.03.019 | |||
| 644077 | 8624 | 35 | None | -5 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1016/j.bmc.2018.03.019 | |||
| CHEMBL373742 | 8624 | 35 | None | -5 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1016/j.bmc.2018.03.019 | |||
| DB00067 | 8624 | 35 | None | -5 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1016/j.bmc.2018.03.019 | |||
| P01185 | 8624 | 35 | None | -5 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1016/j.bmc.2018.03.019 | |||
| P01186 | 8624 | 35 | None | -5 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1016/j.bmc.2018.03.019 | |||
| P35455 | 8624 | 35 | None | -5 | 8 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10.1016/j.bmc.2018.03.019 | |||
| 136961690 | 237392 | 0 | None | 1 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 412 | 3 | 1 | 6 | 4.2 | Cc1ccn(Cc2ccc(C(=O)N3Cc4cnn(C)c4Nc4ccccc43)cc2C)n1 | 10.1021/jm501395b | |||
| CHEMBL3416757 | 237392 | 0 | None | 1 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 412 | 3 | 1 | 6 | 4.2 | Cc1ccn(Cc2ccc(C(=O)N3Cc4cnn(C)c4Nc4ccccc43)cc2C)n1 | 10.1021/jm501395b | |||
| 56668257 | 125926 | 0 | None | 35 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1484 | 18 | 15 | 21 | 3.2 | CC[C@@H](C)[C@H]1NC(=O)[C@@](C)(c2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)N[C@H](C(N)=O)c2ccc(O)cc2)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]([C@@H](C)O)NC1=O | 10.1021/jm010526+ | |||
| CHEMBL1790713 | 125926 | 0 | None | 35 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1484 | 18 | 15 | 21 | 3.2 | CC[C@@H](C)[C@H]1NC(=O)[C@@](C)(c2ccc(O)cc2)NC(=O)CC2(CCCCC2)SSC[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@@H](CCCNC(=O)c2ccc3c(c2)C2(OC3=O)c3ccc(O)cc3Oc3cc(O)ccc32)C(=O)N[C@H](C(N)=O)c2ccc(O)cc2)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H]([C@@H](C)O)NC1=O | 10.1021/jm010526+ | |||
| 44279179 | 200261 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 540 | 6 | 1 | 7 | 3.7 | O=C(Cn1ccccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL287325 | 200261 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 540 | 6 | 1 | 7 | 3.7 | O=C(Cn1ccccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00159-2 | |||
| 44279411 | 216579 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 545 | 6 | 2 | 7 | 2.4 | O=C(CN1C(=O)CNC1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL31476 | 216579 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 545 | 6 | 2 | 7 | 2.4 | O=C(CN1C(=O)CNC1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00159-2 | |||
| 44456382 | 197743 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 467 | 7 | 2 | 4 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1cccs1 | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL270013 | 197743 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 467 | 7 | 2 | 4 | 3.5 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1cccs1 | 10.1016/j.bmcl.2007.11.008 | |||
| 44456036 | 197984 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 451 | 7 | 2 | 4 | 3.0 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccco1 | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL271266 | 197984 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 451 | 7 | 2 | 4 | 3.0 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccco1 | 10.1016/j.bmcl.2007.11.008 | |||
| 44456034 | 308722 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(C)n1 | 10.1016/j.bmcl.2007.11.008 | |||
| CHEMBL401858 | 308722 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H](C)[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(C)n1 | 10.1016/j.bmcl.2007.11.008 | |||
| 44581266 | 349398 | 0 | None | 7 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 479 | 8 | 0 | 6 | 4.7 | COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3F)cn2)c2ccc(OC)nc2)cc1 | 10.1016/j.bmcl.2008.11.018 | |||
| CHEMBL457544 | 349398 | 0 | None | 7 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 479 | 8 | 0 | 6 | 4.7 | COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3F)cn2)c2ccc(OC)nc2)cc1 | 10.1016/j.bmcl.2008.11.018 | |||
| 44581686 | 372703 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 523 | 8 | 0 | 7 | 4.3 | COc1ccc(N(Cc2ccc(-c3ccccc3C)cn2)S(=O)(=O)c2ccc(S(C)(=O)=O)cc2)cn1 | 10.1016/j.bmcl.2008.11.018 | |||
| CHEMBL514586 | 372703 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 523 | 8 | 0 | 7 | 4.3 | COc1ccc(N(Cc2ccc(-c3ccccc3C)cn2)S(=O)(=O)c2ccc(S(C)(=O)=O)cc2)cn1 | 10.1016/j.bmcl.2008.11.018 | |||
| 2252 | 4546 | 39 | None | -1 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/s0960-894x(02)00160-9 | |||
| 6918320 | 4546 | 39 | None | -1 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL24781 | 4546 | 39 | None | -1 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/s0960-894x(02)00160-9 | |||
| 44279909 | 199356 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 590 | 6 | 1 | 7 | 4.8 | O=C(Cn1ccc2ccccc2c1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL281044 | 199356 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 590 | 6 | 1 | 7 | 4.8 | O=C(Cn1ccc2ccccc2c1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| 44279710 | 199572 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 626 | 6 | 1 | 7 | 4.8 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccc(F)cc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL282494 | 199572 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 626 | 6 | 1 | 7 | 4.8 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccc(F)cc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| 44279711 | 199657 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 626 | 6 | 1 | 7 | 4.8 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5cc(F)ccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL283039 | 199657 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 626 | 6 | 1 | 7 | 4.8 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5cc(F)ccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| 44279179 | 200261 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 540 | 6 | 1 | 7 | 3.7 | O=C(Cn1ccccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL287325 | 200261 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 540 | 6 | 1 | 7 | 3.7 | O=C(Cn1ccccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| 11613469 | 142084 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 532 | 7 | 3 | 4 | 3.8 | CC(=O)Nc1cccc([C@H](C(=O)NC(C)(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)c1 | 10.1021/jm050557v | |||
| CHEMBL193773 | 142084 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 532 | 7 | 3 | 4 | 3.8 | CC(=O)Nc1cccc([C@H](C(=O)NC(C)(C)C)N2C(=O)[C@@H](C3Cc4ccccc4C3)NC(=O)[C@H]2CC(C)C)c1 | 10.1021/jm050557v | |||
| CHEMBL2112249 | 485097 | 2 | None | -8 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 766 | 6 | 4 | 7 | 2.6 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 2042 | 8014 | 41 | None | -1 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | |||
| 2176 | 8014 | 41 | None | -1 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | |||
| 439302 | 8014 | 41 | None | -1 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | |||
| CHEMBL395429 | 8014 | 41 | None | -1 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | |||
| 136961690 | 237392 | 0 | None | 1 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 412 | 3 | 1 | 6 | 4.2 | Cc1ccn(Cc2ccc(C(=O)N3Cc4cnn(C)c4Nc4ccccc43)cc2C)n1 | 10.1021/jm501395b | |||
| CHEMBL3416757 | 237392 | 0 | None | 1 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 412 | 3 | 1 | 6 | 4.2 | Cc1ccn(Cc2ccc(C(=O)N3Cc4cnn(C)c4Nc4ccccc43)cc2C)n1 | 10.1021/jm501395b | |||
| 10699323 | 468907 | 0 | None | 2 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 640 | 7 | 0 | 7 | 5.2 | COc1cc(OC2CCN(Cc3c[n+]([O-])ccc3C(F)(F)F)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL69265 | 468907 | 0 | None | 2 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 640 | 7 | 0 | 7 | 5.2 | COc1cc(OC2CCN(Cc3c[n+]([O-])ccc3C(F)(F)F)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL3814165 | 487600 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1020 | 17 | 11 | 15 | -3.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)N(C)C(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | |||
| 2042 | 8014 | 41 | None | -1 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmcl.2008.11.064 | |||
| 2176 | 8014 | 41 | None | -1 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmcl.2008.11.064 | |||
| 439302 | 8014 | 41 | None | -1 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmcl.2008.11.064 | |||
| CHEMBL395429 | 8014 | 41 | None | -1 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1016/j.bmcl.2008.11.064 | |||
| 135475964 | 145086 | 0 | None | 53 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 467 | 9 | 2 | 6 | 3.4 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C/c2ccccc2O)c2ccc(C)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL200329 | 145086 | 0 | None | 53 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 467 | 9 | 2 | 6 | 3.4 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C/c2ccccc2O)c2ccc(C)cc2)cc1 | 10.1021/jm050645f | |||
| 145974527 | 329683 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 491 | 5 | 3 | 6 | 3.3 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)NCC(=S)N(C)C | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL4217872 | 329683 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 491 | 5 | 3 | 6 | 3.3 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)NCC(=S)N(C)C | 10.1021/acs.jmedchem.8b00697 | |||
| 135414288 | 160571 | 0 | None | 79 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 524 | 6 | 2 | 5 | 4.3 | CC(C)(C)c1ccc(S(=O)(=O)N(CC(=O)N/N=C2/C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113213 | 160571 | 0 | None | 79 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 524 | 6 | 2 | 5 | 4.3 | CC(C)(C)c1ccc(S(=O)(=O)N(CC(=O)N/N=C2/C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| 10413997 | 4534 | 5 | None | -1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 510 | 6 | 2 | 4 | 3.6 | O=C(Cc1cnc[nH]1)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCC2(CC1)CCc1c2cccc1)(C)C | 10.1021/jm00077a002 | |||
| 2246 | 4534 | 5 | None | -1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 510 | 6 | 2 | 4 | 3.6 | O=C(Cc1cnc[nH]1)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCC2(CC1)CCc1c2cccc1)(C)C | 10.1021/jm00077a002 | |||
| CHEMBL338522 | 4534 | 5 | None | -1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 510 | 6 | 2 | 4 | 3.6 | O=C(Cc1cnc[nH]1)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCC2(CC1)CCc1c2cccc1)(C)C | 10.1021/jm00077a002 | |||
| 54581528 | 125112 | 0 | None | -16 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 614 | 8 | 0 | 9 | 3.3 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3cccnc3OC)(N3CCC[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)c(OC)c1 | 10.1016/j.bmcl.2011.03.012 | |||
| CHEMBL1779401 | 125112 | 0 | None | -16 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 614 | 8 | 0 | 9 | 3.3 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3cccnc3OC)(N3CCC[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)c(OC)c1 | 10.1016/j.bmcl.2011.03.012 | |||
| 1107812 | 144643 | 7 | None | None | None | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 488 | 8 | 1 | 5 | 4.8 | COc1ccc(S(=O)(=O)N(CC(=O)Nc2cccc(Cl)c2C)c2ccc(C)cc2)cc1OC | 10.1021/jm050645f | |||
| CHEMBL198780 | 144643 | 7 | None | None | None | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 488 | 8 | 1 | 5 | 4.8 | COc1ccc(S(=O)(=O)N(CC(=O)Nc2cccc(Cl)c2C)c2ccc(C)cc2)cc1OC | 10.1021/jm050645f | |||
| 10411308 | 462175 | 0 | None | -39 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 446 | 4 | 1 | 2 | 6.6 | O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1-c1ccccc1 | 10.1021/jm3006146 | |||
| CHEMBL603708 | 462175 | 0 | None | -39 | 3 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 446 | 4 | 1 | 2 | 6.6 | O=C(Nc1ccc(C(=O)N2CCCCc3ccccc32)cc1)c1ccccc1-c1ccccc1 | 10.1021/jm3006146 | |||
| 44279151 | 199616 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 552 | 5 | 0 | 7 | 3.3 | CS(=O)(=O)N1CCN(Cc2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL282781 | 199616 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 552 | 5 | 0 | 7 | 3.3 | CS(=O)(=O)N1CCN(Cc2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| 44279568 | 200220 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 474 | 5 | 0 | 5 | 3.9 | CC(=O)N(C)CCn1ccc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc21 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL286979 | 200220 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 474 | 5 | 0 | 5 | 3.9 | CC(=O)N(C)CCn1ccc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc21 | 10.1016/s0960-894x(02)00159-2 | |||
| 44279165 | 215820 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 4 | 1 | 5 | 3.8 | CC(=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL31350 | 215820 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 447 | 4 | 1 | 5 | 3.8 | CC(=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00159-2 | |||
| 44279483 | 216760 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 501 | 3 | 0 | 5 | 4.9 | CC(=O)N1CCC(c2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL31606 | 216760 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 501 | 3 | 0 | 5 | 4.9 | CC(=O)N1CCC(c2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| 44581683 | 350130 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 423 | 7 | 0 | 8 | 2.9 | COc1ccc(N(Cc2nc(-c3ccccc3)no2)S(=O)(=O)c2ccccn2)cn1 | 10.1016/j.bmcl.2008.11.018 | |||
| CHEMBL459291 | 350130 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 423 | 7 | 0 | 8 | 2.9 | COc1ccc(N(Cc2nc(-c3ccccc3)no2)S(=O)(=O)c2ccccn2)cn1 | 10.1016/j.bmcl.2008.11.018 | |||
| 44581684 | 372648 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 437 | 7 | 0 | 6 | 4.6 | COc1ccc(N(Cc2csc(-c3ccccc3)n2)S(=O)(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2008.11.018 | |||
| CHEMBL514113 | 372648 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 437 | 7 | 0 | 6 | 4.6 | COc1ccc(N(Cc2csc(-c3ccccc3)n2)S(=O)(=O)c2ccccn2)cc1 | 10.1016/j.bmcl.2008.11.018 | |||
| 44279795 | 200187 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 628 | 5 | 0 | 7 | 6.5 | O=C(c1ccc2oc(-c3cncc(Cn4cc(C(F)(F)F)ccc4=O)c3)cc2c1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL286771 | 200187 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 628 | 5 | 0 | 7 | 6.5 | O=C(c1ccc2oc(-c3cncc(Cn4cc(C(F)(F)F)ccc4=O)c3)cc2c1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00160-9 | |||
| 11598556 | 142559 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 501 | 9 | 1 | 3 | 4.3 | C=CCN1C(=O)[C@@H](CC(C)C)N([C@@H](C(=O)NC(C)C)c2ccccc2)C(=O)[C@H]1C1Cc2ccccc2C1 | 10.1021/jm050557v | |||
| CHEMBL194432 | 142559 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 501 | 9 | 1 | 3 | 4.3 | C=CCN1C(=O)[C@@H](CC(C)C)N([C@@H](C(=O)NC(C)C)c2ccccc2)C(=O)[C@H]1C1Cc2ccccc2C1 | 10.1021/jm050557v | |||
| 11488952 | 159212 | 0 | None | -31 | 3 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 501 | 7 | 2 | 4 | 4.2 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc2occc2c1 | 10.1021/jm060073e | |||
| CHEMBL208787 | 159212 | 0 | None | -31 | 3 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 501 | 7 | 2 | 4 | 4.2 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)C)c1ccc2occc2c1 | 10.1021/jm060073e | |||
| 135520373 | 160560 | 0 | None | 56 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 513 | 8 | 2 | 7 | 2.8 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccncc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113202 | 160560 | 0 | None | 56 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 513 | 8 | 2 | 7 | 2.8 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccncc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| 44419030 | 317154 | 22 | None | -407 | 4 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 1025 | 18 | 11 | 14 | -1.5 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| CHEMBL412972 | 317154 | 22 | None | -407 | 4 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 1025 | 18 | 11 | 14 | -1.5 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| 135520373 | 160560 | 0 | None | 56 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 513 | 8 | 2 | 7 | 2.8 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccncc32)c2ccc(Cl)cc2)cc1 | 10.1039/C5MD00566C | |||
| CHEMBL2113202 | 160560 | 0 | None | 56 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 513 | 8 | 2 | 7 | 2.8 | CCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccncc32)c2ccc(Cl)cc2)cc1 | 10.1039/C5MD00566C | |||
| 10721511 | 202732 | 0 | None | -2 | 2 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 555 | 7 | 0 | 6 | 5.5 | COc1cc(OC2CCN(Cc3ccccc3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL304577 | 202732 | 0 | None | -2 | 2 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 555 | 7 | 0 | 6 | 5.5 | COc1cc(OC2CCN(Cc3ccccc3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 119369 | 5304 | 49 | None | -5 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 427 | 4 | 1 | 3 | 5.3 | O=C(N1CCCC(c2c1cccc2)N(C)C)c1ccc(cc1)NC(=O)c1ccccc1C | 10.1021/jm3006146 | |||
| 2197 | 5304 | 49 | None | -5 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 427 | 4 | 1 | 3 | 5.3 | O=C(N1CCCC(c2c1cccc2)N(C)C)c1ccc(cc1)NC(=O)c1ccccc1C | 10.1021/jm3006146 | |||
| 4004 | 5304 | 49 | None | -5 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 427 | 4 | 1 | 3 | 5.3 | O=C(N1CCCC(c2c1cccc2)N(C)C)c1ccc(cc1)NC(=O)c1ccccc1C | 10.1021/jm3006146 | |||
| CHEMBL420762 | 5304 | 49 | None | -5 | 6 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 427 | 4 | 1 | 3 | 5.3 | O=C(N1CCCC(c2c1cccc2)N(C)C)c1ccc(cc1)NC(=O)c1ccccc1C | 10.1021/jm3006146 | |||
| CHEMBL2369835 | 477595 | 0 | None | -4 | 4 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 1069 | 19 | 13 | 15 | -3.7 | NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N1 | 10.1021/jm030611c | |||
| 71451749 | 163801 | 0 | None | -25 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 1205 | 25 | 7 | 15 | 9.2 | O=C(CCC(=O)NC1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc21)NCc1cn(CCOCCOCCOCCNC(=S)Nc2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)nn1 | 10.1021/jm3006146 | |||
| CHEMBL2172288 | 163801 | 0 | None | -25 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 1205 | 25 | 7 | 15 | 9.2 | O=C(CCC(=O)NC1CCCN(C(=O)c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2)c2ccccc21)NCc1cn(CCOCCOCCOCCNC(=S)Nc2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)nn1 | 10.1021/jm3006146 | |||
| 135515655 | 24368 | 7 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 423 | 7 | 2 | 5 | 3.0 | Cc1ccc(N(CC(=O)N/N=C/c2ccccc2O)S(=O)(=O)c2ccccc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL115305 | 24368 | 7 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 423 | 7 | 2 | 5 | 3.0 | Cc1ccc(N(CC(=O)N/N=C/c2ccccc2O)S(=O)(=O)c2ccccc2)cc1 | 10.1021/jm050645f | |||
| 135537472 | 145202 | 2 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 443 | 7 | 2 | 5 | 3.4 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccccc1)N/N=C/c1ccccc1O | 10.1021/jm050645f | |||
| CHEMBL200792 | 145202 | 2 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 443 | 7 | 2 | 5 | 3.4 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccccc1)N/N=C/c1ccccc1O | 10.1021/jm050645f | |||
| CHEMBL3813858 | 487595 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 1034 | 17 | 10 | 15 | -2.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC(C)C)C(=O)NCC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | |||
| 145974638 | 329526 | 0 | None | -4 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 347 | 2 | 1 | 4 | 3.7 | Cc1ccn(-c2ccc(C(=O)N3CCCC(O)c4ccccc43)cc2)n1 | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL4215696 | 329526 | 0 | None | -4 | 3 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 347 | 2 | 1 | 4 | 3.7 | Cc1ccn(-c2ccc(C(=O)N3CCCC(O)c4ccccc43)cc2)n1 | 10.1021/acs.jmedchem.8b00697 | |||
| 44361522 | 240294 | 0 | None | -12 | 5 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 477 | 4 | 0 | 5 | 3.8 | CC(=O)N1CCC(Oc2ccc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc2)CC1 | 10.1021/jm00023a002 | |||
| CHEMBL358793 | 240294 | 0 | None | -12 | 5 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 477 | 4 | 0 | 5 | 3.8 | CC(=O)N1CCC(Oc2ccc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc2)CC1 | 10.1021/jm00023a002 | |||
| 10579644 | 468901 | 0 | None | 2 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 612 | 6 | 0 | 7 | 5.0 | COc1cc(OC2CCN(C3CCCc4c3ccc[n+]4[O-])CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL69201 | 468901 | 0 | None | 2 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 612 | 6 | 0 | 7 | 5.0 | COc1cc(OC2CCN(C3CCCc4c3ccc[n+]4[O-])CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 135508167 | 160548 | 0 | None | 3 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 596 | 10 | 3 | 8 | 2.8 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(NCCN2CCOCC2)cc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm050645f | |||
| CHEMBL2113177 | 160548 | 0 | None | 3 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 596 | 10 | 3 | 8 | 2.8 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(NCCN2CCOCC2)cc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm050645f | |||
| 135469685 | 160569 | 0 | None | 4 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 542 | 10 | 2 | 7 | 3.0 | COCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL2113211 | 160569 | 0 | None | 4 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 542 | 10 | 2 | 7 | 3.0 | COCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1021/jm050645f | |||
| 54586392 | 125118 | 0 | None | -177 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 695 | 9 | 0 | 9 | 3.6 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3ccc(CN4CCN(C)CC4)cc3OC)(N3CCC[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)cc1 | 10.1016/j.bmcl.2011.03.012 | |||
| CHEMBL1779407 | 125118 | 0 | None | -177 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 695 | 9 | 0 | 9 | 3.6 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3ccc(CN4CCN(C)CC4)cc3OC)(N3CCC[C@H]3C(=O)N(C)C)c3cc(Cl)ccc32)cc1 | 10.1016/j.bmcl.2011.03.012 | |||
| 135469685 | 160569 | 0 | None | 4 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 542 | 10 | 2 | 7 | 3.0 | COCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1039/C5MD00566C | |||
| CHEMBL2113211 | 160569 | 0 | None | 4 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 542 | 10 | 2 | 7 | 3.0 | COCCOc1ccc(S(=O)(=O)N(CC(=O)N/N=C2\C(=O)Nc3ccccc32)c2ccc(Cl)cc2)cc1 | 10.1039/C5MD00566C | |||
| CHEMBL1790546 | 484183 | 0 | None | 85 | 2 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 738 | 6 | 2 | 8 | 2.3 | CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCC=NN2C(=O)[C@H]2CCC=NN2C1=O | 10.1021/jm00171a003 | |||
| 2241 | 4522 | 5 | None | -2 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 738 | 6 | 2 | 8 | 2.3 | CC[C@@H]([C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](N(C(=O)[C@H]2N(C(=O)[C@@H]3N(C1=O)N=CCC3)N=CCC2)C)Cc1ccccc1)C | 10.1021/jm00099a019 | |||
| 9810632 | 4522 | 5 | None | -2 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 738 | 6 | 2 | 8 | 2.3 | CC[C@@H]([C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](N(C(=O)[C@H]2N(C(=O)[C@@H]3N(C1=O)N=CCC3)N=CCC2)C)Cc1ccccc1)C | 10.1021/jm00099a019 | |||
| CHEMBL127686 | 4522 | 5 | None | -2 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 738 | 6 | 2 | 8 | 2.3 | CC[C@@H]([C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](N(C(=O)[C@H]2N(C(=O)[C@@H]3N(C1=O)N=CCC3)N=CCC2)C)Cc1ccccc1)C | 10.1021/jm00099a019 | |||
| 2241 | 4522 | 5 | None | -2 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 738 | 6 | 2 | 8 | 2.3 | CC[C@@H]([C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](N(C(=O)[C@H]2N(C(=O)[C@@H]3N(C1=O)N=CCC3)N=CCC2)C)Cc1ccccc1)C | 10.1021/jm00169a001 | |||
| 9810632 | 4522 | 5 | None | -2 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 738 | 6 | 2 | 8 | 2.3 | CC[C@@H]([C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](N(C(=O)[C@H]2N(C(=O)[C@@H]3N(C1=O)N=CCC3)N=CCC2)C)Cc1ccccc1)C | 10.1021/jm00169a001 | |||
| CHEMBL127686 | 4522 | 5 | None | -2 | 4 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 738 | 6 | 2 | 8 | 2.3 | CC[C@@H]([C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](N(C(=O)[C@H]2N(C(=O)[C@@H]3N(C1=O)N=CCC3)N=CCC2)C)Cc1ccccc1)C | 10.1021/jm00169a001 | |||
| 11756466 | 19427 | 0 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 521 | 6 | 0 | 6 | 4.4 | COc1cc(O[C@H](C)c2cc[n+]([O-])cc2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL105514 | 19427 | 0 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 521 | 6 | 0 | 6 | 4.4 | COc1cc(O[C@H](C)c2cc[n+]([O-])cc2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| 53319051 | 119141 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 1174 | 17 | 12 | 13 | -4.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)C[Te][Te]C[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| CHEMBL1630525 | 119141 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 1174 | 17 | 12 | 13 | -4.4 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)C[Te][Te]C[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| 44214438 | 461726 | 0 | None | -3 | 2 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 630 | 6 | 0 | 7 | 5.2 | COc1cc(OC2CCN(C3CCCc4c3ccc[n+]4[O-])CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL66992 | 461726 | 0 | None | -3 | 2 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 630 | 6 | 0 | 7 | 5.2 | COc1cc(OC2CCN(C3CCCc4c3ccc[n+]4[O-])CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 10840517 | 468876 | 0 | None | 3 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 556 | 7 | 0 | 7 | 4.9 | COc1cc(OC2CCN(Cc3ccncc3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL68978 | 468876 | 0 | None | 3 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 556 | 7 | 0 | 7 | 4.9 | COc1cc(OC2CCN(Cc3ccncc3)CC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL52176 | 489105 | 0 | None | 229 | 2 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 755 | 6 | 5 | 7 | 1.9 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCN2C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H]2CCCCN2C(=O)[C@@H]2CCCCN2C1=O | 10.1021/jm00169a001 | |||
| 44335300 | 18983 | 0 | None | 5 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 486 | 6 | 0 | 5 | 5.6 | COc1cc(OC(C)c2ccccc2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL102994 | 18983 | 0 | None | 5 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 486 | 6 | 0 | 5 | 5.6 | COc1cc(OC(C)c2ccccc2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| 56950450 | 156711 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 475 | 7 | 2 | 3 | 3.7 | Cc1ccccc1[C@H](C(=O)NC(C)C)N1C(=O)[C@@H](C2Cc3ccccc3C2)NC(=O)[C@H]1CC(C)C | 10.1021/jm201287w | |||
| CHEMBL2035010 | 156711 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 475 | 7 | 2 | 3 | 3.7 | Cc1ccccc1[C@H](C(=O)NC(C)C)N1C(=O)[C@@H](C2Cc3ccccc3C2)NC(=O)[C@H]1CC(C)C | 10.1021/jm201287w | |||
| 44581242 | 349863 | 0 | None | 3 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 475 | 8 | 0 | 6 | 4.9 | COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3C)cn2)c2ccc(OC)nc2)cc1 | 10.1016/j.bmcl.2008.11.018 | |||
| CHEMBL458635 | 349863 | 0 | None | 3 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 475 | 8 | 0 | 6 | 4.9 | COc1ccc(S(=O)(=O)N(Cc2ccc(-c3ccccc3C)cn2)c2ccc(OC)nc2)cc1 | 10.1016/j.bmcl.2008.11.018 | |||
| 44279521 | 200235 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 626 | 6 | 1 | 7 | 4.8 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)c(F)cc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL287101 | 200235 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 626 | 6 | 1 | 7 | 4.8 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)c(F)cc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| 44279709 | 213533 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 626 | 6 | 1 | 7 | 4.8 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5cccc(F)c54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL30910 | 213533 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 626 | 6 | 1 | 7 | 4.8 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1cc2cc(C(=O)N3CCC(N4C(=O)OCc5cccc(F)c54)CC3)ccc2o1 | 10.1016/s0960-894x(02)00160-9 | |||
| 44459838 | 199816 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 635 | 12 | 3 | 6 | 3.6 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL284120 | 199816 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 635 | 12 | 3 | 6 | 3.6 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| 2204 | 8913 | 7 | None | -229 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 616 | 5 | 1 | 5 | 6.4 | O=C(N1CCC(CC1)N1CCCCC1)/C=C\1/c2ccccc2N(CCC1(F)F)C(=O)c1ccc(cc1)NC(=O)c1ccoc1C | 10.1021/acs.jmedchem.8b00697 | |||
| 9917025 | 8913 | 7 | None | -229 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 616 | 5 | 1 | 5 | 6.4 | O=C(N1CCC(CC1)N1CCCCC1)/C=C\1/c2ccccc2N(CCC1(F)F)C(=O)c1ccc(cc1)NC(=O)c1ccoc1C | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL3307200 | 8913 | 7 | None | -229 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 616 | 5 | 1 | 5 | 6.4 | O=C(N1CCC(CC1)N1CCCCC1)/C=C\1/c2ccccc2N(CCC1(F)F)C(=O)c1ccc(cc1)NC(=O)c1ccoc1C | 10.1021/acs.jmedchem.8b00697 | |||
| 19691006 | 19509 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 493 | 6 | 1 | 6 | 4.2 | COc1cc(OC(C)C2CCNCC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL105960 | 19509 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 493 | 6 | 1 | 6 | 4.2 | COc1cc(OC(C)C2CCNCC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| 44334990 | 217810 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 472 | 6 | 0 | 5 | 5.0 | COc1cc(OCc2ccccc2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL319646 | 217810 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 472 | 6 | 0 | 5 | 5.0 | COc1cc(OCc2ccccc2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| 137212770 | 275439 | 0 | None | -28 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 532 | 10 | 1 | 8 | 4.4 | COc1cc(CN2CCN(CCCCCC(=O)N3Cc4cnn(C)c4Nc4ccccc43)CC2)cc(OC)c1 | 10.1016/j.ejmech.2015.11.050 | |||
| CHEMBL3765356 | 275439 | 0 | None | -28 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 532 | 10 | 1 | 8 | 4.4 | COc1cc(CN2CCN(CCCCCC(=O)N3Cc4cnn(C)c4Nc4ccccc43)CC2)cc(OC)c1 | 10.1016/j.ejmech.2015.11.050 | |||
| 15951937 | 237441 | 0 | None | -1905 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 366 | 1 | 1 | 2 | 4.5 | O=C(c1c[nH]c2cc(Cl)ccc12)N1CCC2(CC1)OCc1ccccc12 | 10.1021/jm501745f | |||
| CHEMBL3416861 | 237441 | 0 | None | -1905 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 366 | 1 | 1 | 2 | 4.5 | O=C(c1c[nH]c2cc(Cl)ccc12)N1CCC2(CC1)OCc1ccccc12 | 10.1021/jm501745f | |||
| 2213 | 1072 | 37 | None | -20 | 5 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm050645f | |||
| 3008 | 1072 | 37 | None | -20 | 5 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm050645f | |||
| 5311010 | 1072 | 37 | None | -20 | 5 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm050645f | |||
| 68613 | 1072 | 37 | None | -20 | 5 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm050645f | |||
| CHEMBL378642 | 1072 | 37 | None | -20 | 5 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm050645f | |||
| CHEMBL382301 | 1072 | 37 | None | -20 | 5 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm050645f | |||
| DB09059 | 1072 | 37 | None | -20 | 5 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10.1021/jm050645f | |||
| 11620428 | 278509 | 0 | None | 2 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 509 | 9 | 1 | 6 | 2.9 | CCOc1ccc(S(=O)(=O)N(CC(=O)N2Cc3ccccc3C2C(N)=O)c2ccc(OC)cc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL383149 | 278509 | 0 | None | 2 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 509 | 9 | 1 | 6 | 2.9 | CCOc1ccc(S(=O)(=O)N(CC(=O)N2Cc3ccccc3C2C(N)=O)c2ccc(OC)cc2)cc1 | 10.1021/jm050645f | |||
| 70685423 | 155348 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 541 | 6 | 1 | 6 | 2.7 | CS(=O)(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)CCc5ccccc54)CC3)c(O)c2)CC1 | 10.1016/j.bmc.2012.02.019 | |||
| CHEMBL2017980 | 155348 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 541 | 6 | 1 | 6 | 2.7 | CS(=O)(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)CCc5ccccc54)CC3)c(O)c2)CC1 | 10.1016/j.bmc.2012.02.019 | |||
| 44279168 | 200119 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 516 | 4 | 0 | 6 | 3.9 | CC(=O)N1CCN(Cc2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL28627 | 200119 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 516 | 4 | 0 | 6 | 3.9 | CC(=O)N1CCN(Cc2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| 44279482 | 217934 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 537 | 4 | 0 | 6 | 4.3 | CS(=O)(=O)N1CCC(c2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL31978 | 217934 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 537 | 4 | 0 | 6 | 4.3 | CS(=O)(=O)N1CCC(c2cc3cc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)ccc3o2)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| 44279574 | 199612 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 625 | 6 | 1 | 8 | 4.6 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1nc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2s1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL282767 | 199612 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 625 | 6 | 1 | 8 | 4.6 | O=C(Cn1cc(C(F)(F)F)ccc1=O)NCc1nc2cc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)ccc2s1 | 10.1016/s0960-894x(02)00160-9 | |||
| 11627894 | 142520 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 529 | 7 | 2 | 3 | 4.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccc(C(F)(F)F)cc1 | 10.1021/jm050557v | |||
| 11663715 | 142520 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 529 | 7 | 2 | 3 | 4.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccc(C(F)(F)F)cc1 | 10.1021/jm050557v | |||
| CHEMBL194233 | 142520 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 529 | 7 | 2 | 3 | 4.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccc(C(F)(F)F)cc1 | 10.1021/jm050557v | |||
| CHEMBL198329 | 142520 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 529 | 7 | 2 | 3 | 4.4 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@H](C(=O)NC(C)C)c1ccc(C(F)(F)F)cc1 | 10.1021/jm050557v | |||
| 11385982 | 142544 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 475 | 6 | 2 | 3 | 3.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccccc1 | 10.1021/jm050557v | |||
| 11408910 | 142544 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 475 | 6 | 2 | 3 | 3.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccccc1 | 10.1021/jm050557v | |||
| CHEMBL194374 | 142544 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 475 | 6 | 2 | 3 | 3.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccccc1 | 10.1021/jm050557v | |||
| CHEMBL198328 | 142544 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 475 | 6 | 2 | 3 | 3.8 | CC(C)C[C@@H]1C(=O)N[C@H](C2Cc3ccccc3C2)C(=O)N1[C@@H](C(=O)NC(C)(C)C)c1ccccc1 | 10.1021/jm050557v | |||
| 44274944 | 333340 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 585 | 12 | 3 | 6 | 2.4 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(F)cc2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL436540 | 333340 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 585 | 12 | 3 | 6 | 2.4 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(F)cc2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| 44279556 | 200229 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 389 | 2 | 1 | 3 | 4.2 | Cc1c[nH]c2ccc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc12 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL287067 | 200229 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 389 | 2 | 1 | 3 | 4.2 | Cc1c[nH]c2ccc(C(=O)N3CCC(N4C(=O)OCc5ccccc54)CC3)cc12 | 10.1016/s0960-894x(02)00159-2 | |||
| 44279260 | 216817 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 376 | 2 | 1 | 4 | 3.3 | O=C(c1ccc2[nH]ccc2n1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL31645 | 216817 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 376 | 2 | 1 | 4 | 3.3 | O=C(c1ccc2[nH]ccc2n1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| 44278973 | 218206 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 393 | 2 | 0 | 5 | 4.1 | O=C(c1ccc2ncsc2c1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| CHEMBL32054 | 218206 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 393 | 2 | 0 | 5 | 4.1 | O=C(c1ccc2ncsc2c1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00159-2 | |||
| 44279714 | 202938 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 634 | 5 | 0 | 7 | 6.2 | O=C(c1ccc2oc(CN3CCC(n4cc(C(F)(F)F)ccc4=O)CC3)cc2c1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL30587 | 202938 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 634 | 5 | 0 | 7 | 6.2 | O=C(c1ccc2oc(CN3CCC(n4cc(C(F)(F)F)ccc4=O)CC3)cc2c1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00160-9 | |||
| 44279794 | 216694 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 627 | 5 | 0 | 6 | 7.1 | O=C(c1ccc2oc(-c3cccc(Cn4cc(C(F)(F)F)ccc4=O)c3)cc2c1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00160-9 | |||
| CHEMBL31556 | 216694 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 627 | 5 | 0 | 6 | 7.1 | O=C(c1ccc2oc(-c3cccc(Cn4cc(C(F)(F)F)ccc4=O)c3)cc2c1)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(02)00160-9 | |||
| 44274620 | 194305 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 565 | 8 | 3 | 5 | 2.9 | CC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| 44274660 | 194305 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 565 | 8 | 3 | 5 | 2.9 | CC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL24806 | 194305 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 565 | 8 | 3 | 5 | 2.9 | CC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL422044 | 194305 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 565 | 8 | 3 | 5 | 2.9 | CC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| 44274928 | 199007 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 573 | 12 | 3 | 6 | 3.0 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@@H](CC2CCCCC2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL278093 | 199007 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 573 | 12 | 3 | 6 | 3.0 | CC(=O)CCCC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)N[C@@H](CC2CCCCC2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| 44275001 | 199057 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 639 | 13 | 3 | 8 | 2.4 | CC(=O)CCCC(=O)NC1N=C(Cn2ccnc2)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL278619 | 199057 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 639 | 13 | 3 | 8 | 2.4 | CC(=O)CCCC(=O)NC1N=C(Cn2ccnc2)c2ccccc2N(CC(=O)N[C@@H](Cc2ccc(Cl)c(Cl)c2)C(N)=O)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| 44275012 | 199104 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 508 | 7 | 2 | 7 | 2.7 | CC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)NCc2nc(-c3ccccc3)no2)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| CHEMBL278988 | 199104 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 508 | 7 | 2 | 7 | 2.7 | CC(=O)NC1N=C(c2ccccc2)c2ccccc2N(CC(=O)NCc2nc(-c3ccccc3)no2)C1=O | 10.1016/s0960-894x(01)00202-5 | |||
| 10817776 | 468809 | 0 | None | -5 | 2 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 628 | 8 | 0 | 7 | 5.3 | CCc1c(CN2CCC(Oc3ccc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)c(OC)c3)CC2)c(C)cc(C)[n+]1[O-] | 10.1021/jm9800797 | |||
| CHEMBL68480 | 468809 | 0 | None | -5 | 2 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 628 | 8 | 0 | 7 | 5.3 | CCc1c(CN2CCC(Oc3ccc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)c(OC)c3)CC2)c(C)cc(C)[n+]1[O-] | 10.1021/jm9800797 | |||
| 135476004 | 160551 | 0 | None | -8 | 3 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 597 | 10 | 2 | 8 | 2.7 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(OCCN2CCOCC2)cc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm050645f | |||
| CHEMBL2113185 | 160551 | 0 | None | -8 | 3 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 597 | 10 | 2 | 8 | 2.7 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccc(OCCN2CCOCC2)cc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm050645f | |||
| CHEMBL1790547 | 484806 | 0 | None | 57 | 2 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 736 | 6 | 2 | 8 | 2.0 | CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2C=CC=NN2C(=O)[C@H]2CCC=NN2C1=O | 10.1021/jm00171a003 | |||
| CHEMBL300642 | 486409 | 0 | None | 32 | 2 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 779 | 6 | 3 | 6 | 3.6 | CC[C@H](C)[C@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00169a001 | |||
| 10675476 | 461752 | 0 | None | -5 | 2 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 630 | 6 | 0 | 7 | 5.2 | COc1cc(OC2CCN([C@H]3CCCc4c3ccc[n+]4[O-])CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL68800 | 461752 | 0 | None | -5 | 2 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 630 | 6 | 0 | 7 | 5.2 | COc1cc(OC2CCN([C@H]3CCCc4c3ccc[n+]4[O-])CC2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 10603831 | 468902 | 0 | None | -3 | 2 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 614 | 9 | 0 | 7 | 5.1 | CCCc1c(CN2CCC(Oc3ccc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)c(OC)c3)CC2)ccc[n+]1[O-] | 10.1021/jm9800797 | |||
| CHEMBL69202 | 468902 | 0 | None | -3 | 2 | Rat | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 614 | 9 | 0 | 7 | 5.1 | CCCc1c(CN2CCC(Oc3ccc(C(=O)N4CCC(N5C(=O)OCc6ccccc65)CC4)c(OC)c3)CC2)ccc[n+]1[O-] | 10.1021/jm9800797 | |||
| 135438362 | 160565 | 0 | None | 70 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 468 | 6 | 2 | 5 | 3.0 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccccc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm050645f | |||
| CHEMBL2113207 | 160565 | 0 | None | 70 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 468 | 6 | 2 | 5 | 3.0 | O=C(CN(c1ccc(Cl)cc1)S(=O)(=O)c1ccccc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm050645f | |||
| 1134627 | 145178 | 9 | None | -11 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 444 | 7 | 1 | 4 | 4.5 | COc1ccc(N(CC(=O)Nc2ccc(Cl)cc2C)S(=O)(=O)c2ccccc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL200682 | 145178 | 9 | None | -11 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 444 | 7 | 1 | 4 | 4.5 | COc1ccc(N(CC(=O)Nc2ccc(Cl)cc2C)S(=O)(=O)c2ccccc2)cc1 | 10.1021/jm050645f | |||
| 145976546 | 328610 | 0 | None | -7 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 381 | 2 | 1 | 4 | 4.3 | Cc1ccn(-c2ccc(C(=O)N3CCCC(O)c4ccccc43)c(Cl)c2)n1 | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL4204008 | 328610 | 0 | None | -7 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 381 | 2 | 1 | 4 | 4.3 | Cc1ccn(-c2ccc(C(=O)N3CCCC(O)c4ccccc43)c(Cl)c2)n1 | 10.1021/acs.jmedchem.8b00697 | |||
| 137212772 | 275327 | 0 | None | -12 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 609 | 7 | 2 | 8 | 4.7 | COc1cc(CN2CCN(C(=O)NCc3ccc(C(=O)N4Cc5cnn(C)c5Nc5ccccc54)cc3C)CC2)cc(OC)c1 | 10.1016/j.ejmech.2017.10.059 | |||
| CHEMBL3763951 | 275327 | 0 | None | -12 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 609 | 7 | 2 | 8 | 4.7 | COc1cc(CN2CCN(C(=O)NCc3ccc(C(=O)N4Cc5cnn(C)c5Nc5ccccc54)cc3C)CC2)cc(OC)c1 | 10.1016/j.ejmech.2017.10.059 | |||
| 137212772 | 275327 | 0 | None | -12 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 609 | 7 | 2 | 8 | 4.7 | COc1cc(CN2CCN(C(=O)NCc3ccc(C(=O)N4Cc5cnn(C)c5Nc5ccccc54)cc3C)CC2)cc(OC)c1 | 10.1016/j.ejmech.2015.11.050 | |||
| CHEMBL3763951 | 275327 | 0 | None | -12 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 609 | 7 | 2 | 8 | 4.7 | COc1cc(CN2CCN(C(=O)NCc3ccc(C(=O)N4Cc5cnn(C)c5Nc5ccccc54)cc3C)CC2)cc(OC)c1 | 10.1016/j.ejmech.2015.11.050 | |||
| 71455302 | 163803 | 0 | None | -194 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 1441 | 33 | 5 | 17 | 10.3 | CCN1/C(=C/C=C/C=C/C2=[N+](CC)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)C(C)(CCCC(=O)NCCOCCOCCOCCn2cc(CNC(=O)CCC(=O)NC3CCCN(C(=O)c4ccc(NC(=O)c5ccccc5-c5ccccc5)cc4)c4ccccc43)nn2)c2cc(S(=O)(=O)O)ccc21 | 10.1021/jm3006146 | |||
| 71482380 | 163803 | 0 | None | -194 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 1441 | 33 | 5 | 17 | 10.3 | CCN1/C(=C/C=C/C=C/C2=[N+](CC)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)C(C)(CCCC(=O)NCCOCCOCCOCCn2cc(CNC(=O)CCC(=O)NC3CCCN(C(=O)c4ccc(NC(=O)c5ccccc5-c5ccccc5)cc4)c4ccccc43)nn2)c2cc(S(=O)(=O)O)ccc21 | 10.1021/jm3006146 | |||
| CHEMBL2172290 | 163803 | 0 | None | -194 | 3 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 1441 | 33 | 5 | 17 | 10.3 | CCN1/C(=C/C=C/C=C/C2=[N+](CC)c3ccc(S(=O)(=O)[O-])cc3C2(C)C)C(C)(CCCC(=O)NCCOCCOCCOCCn2cc(CNC(=O)CCC(=O)NC3CCCN(C(=O)c4ccc(NC(=O)c5ccccc5-c5ccccc5)cc4)c4ccccc43)nn2)c2cc(S(=O)(=O)O)ccc21 | 10.1021/jm3006146 | |||
| 10837896 | 468941 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 3.6 | COc1cc(OC2CCNCC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| CHEMBL69498 | 468941 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 3.6 | COc1cc(OC2CCNCC2)ccc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1021/jm9800797 | |||
| 44419025 | 175267 | 18 | None | -3311 | 8 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 1039 | 17 | 13 | 14 | -2.7 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| 44419026 | 175267 | 18 | None | -3311 | 8 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 1039 | 17 | 13 | 14 | -2.7 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| 74992363 | 175267 | 18 | None | -3311 | 8 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 1039 | 17 | 13 | 14 | -2.7 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| CHEMBL221436 | 175267 | 18 | None | -3311 | 8 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 1039 | 17 | 13 | 14 | -2.7 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| CHEMBL435323 | 175267 | 18 | None | -3311 | 8 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 1039 | 17 | 13 | 14 | -2.7 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| CHEMBL6015151 | 175267 | 18 | None | -3311 | 8 | Rat | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 1039 | 17 | 13 | 14 | -2.7 | CC(C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| CHEMBL339118 | 487010 | 0 | None | 19 | 2 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 740 | 6 | 2 | 6 | 3.1 | CC[C@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00169a001 | |||
| 137212776 | 275320 | 0 | None | -128 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 532 | 10 | 3 | 8 | 4.6 | Cn1ncc2c1Nc1ccccc1N(C(=O)CCCCCCCN1CCN(Cc3cc(O)cc(O)c3)CC1)C2 | 10.1016/j.ejmech.2017.10.059 | |||
| CHEMBL3763823 | 275320 | 0 | None | -128 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 532 | 10 | 3 | 8 | 4.6 | Cn1ncc2c1Nc1ccccc1N(C(=O)CCCCCCCN1CCN(Cc3cc(O)cc(O)c3)CC1)C2 | 10.1016/j.ejmech.2017.10.059 | |||
| 137212776 | 275320 | 0 | None | -128 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 532 | 10 | 3 | 8 | 4.6 | Cn1ncc2c1Nc1ccccc1N(C(=O)CCCCCCCN1CCN(Cc3cc(O)cc(O)c3)CC1)C2 | 10.1016/j.ejmech.2015.11.050 | |||
| CHEMBL3763823 | 275320 | 0 | None | -128 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 532 | 10 | 3 | 8 | 4.6 | Cn1ncc2c1Nc1ccccc1N(C(=O)CCCCCCCN1CCN(Cc3cc(O)cc(O)c3)CC1)C2 | 10.1016/j.ejmech.2015.11.050 | |||
| 145978570 | 328785 | 0 | None | -2 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 331 | 2 | 0 | 3 | 4.2 | Cc1ccn(-c2ccc(C(=O)N3CCCCc4ccccc43)cc2)n1 | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL4206233 | 328785 | 0 | None | -2 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 331 | 2 | 0 | 3 | 4.2 | Cc1ccn(-c2ccc(C(=O)N3CCCCc4ccccc43)cc2)n1 | 10.1021/acs.jmedchem.8b00697 | |||
| 46233065 | 451524 | 0 | None | -1 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 548 | 4 | 2 | 5 | 4.1 | Cc1cc(C(=O)N2CCCNc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1 | 10.1021/jm901084f | |||
| CHEMBL602671 | 451524 | 0 | None | -1 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 548 | 4 | 2 | 5 | 4.1 | Cc1cc(C(=O)N2CCCNc3ccccc32)ccc1CNC(=O)N1CCC[C@H]1C(=S)N1CCCN(C)CC1 | 10.1021/jm901084f | |||
| 73346892 | 180193 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 975 | 17 | 12 | 14 | -3.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| CHEMBL2369424 | 180193 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 975 | 17 | 12 | 14 | -3.7 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1021/jm100989w | |||
| 44275618 | 198042 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 396 | 4 | 0 | 5 | 3.5 | COc1ccc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)c(OC)c1 | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL27157 | 198042 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 396 | 4 | 0 | 5 | 3.5 | COc1ccc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)c(OC)c1 | 10.1016/s0960-894x(98)00568-x | |||
| 44275618 | 198042 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 396 | 4 | 0 | 5 | 3.5 | COc1ccc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)c(OC)c1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL27157 | 198042 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 396 | 4 | 0 | 5 | 3.5 | COc1ccc(C(=O)N2CCC(N3C(=O)OCc4ccccc43)CC2)c(OC)c1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL1790543 | 484805 | 0 | None | 61 | 2 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 756 | 6 | 4 | 8 | 0.8 | CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCC(=O)NN2C(=O)[C@H]2CCCNN2C1=O | 10.1021/jm00171a003 | |||
| 54580518 | 125129 | 0 | None | -69 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 691 | 9 | 0 | 10 | 4.9 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3cc(CN4CCN(C)CC4)ccc3OC)(N3CCC[C@H]3c3ncco3)c3cc(Cl)ccc32)cc1 | 10.1016/j.bmcl.2011.03.012 | |||
| CHEMBL1779420 | 125129 | 0 | None | -69 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 691 | 9 | 0 | 10 | 4.9 | COc1ccc(S(=O)(=O)N2C(=O)[C@@](c3cc(CN4CCN(C)CC4)ccc3OC)(N3CCC[C@H]3c3ncco3)c3cc(Cl)ccc32)cc1 | 10.1016/j.bmcl.2011.03.012 | |||
| 25212177 | 348862 | 6 | None | 7 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 463 | 7 | 0 | 7 | 3.9 | COc1ccc(N(Cc2ccc(-c3ccccc3C)cn2)S(=O)(=O)c2cn(C)c(C)n2)cn1 | 10.1021/jm901812z | |||
| CHEMBL456263 | 348862 | 6 | None | 7 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 463 | 7 | 0 | 7 | 3.9 | COc1ccc(N(Cc2ccc(-c3ccccc3C)cn2)S(=O)(=O)c2cn(C)c(C)n2)cn1 | 10.1021/jm901812z | |||
| 2252 | 4546 | 39 | None | -1 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/s0960-894x(98)00568-x | |||
| 6918320 | 4546 | 39 | None | -1 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL24781 | 4546 | 39 | None | -1 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/s0960-894x(98)00568-x | |||
| 2252 | 4546 | 39 | None | -1 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/s0960-894x(99)00181-x | |||
| 6918320 | 4546 | 39 | None | -1 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL24781 | 4546 | 39 | None | -1 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL1790937 | 484815 | 0 | None | -2 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 755 | 6 | 5 | 7 | 1.9 | CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H]2CCCCN2C(=O)[C@H]2CCCCN2C1=O | 10.1021/jm00099a019 | |||
| 11683187 | 444222 | 42 | None | 117 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 419 | 7 | 0 | 8 | 2.9 | COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/jm901812z | |||
| CHEMBL594828 | 444222 | 42 | None | 117 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 419 | 7 | 0 | 8 | 2.9 | COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/jm901812z | |||
| 11683187 | 444222 | 42 | None | 117 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 419 | 7 | 0 | 8 | 2.9 | COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/jm901812z | |||
| CHEMBL594828 | 444222 | 42 | None | 117 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 419 | 7 | 0 | 8 | 2.9 | COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1 | 10.1021/jm901812z | |||
| 2042 | 8014 | 41 | None | -1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | |||
| 2176 | 8014 | 41 | None | -1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | |||
| 439302 | 8014 | 41 | None | -1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | |||
| CHEMBL395429 | 8014 | 41 | None | -1 | 6 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10.1021/jm501395b | |||
| CHEMBL1790542 | 484804 | 0 | None | 346 | 2 | Rat | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 754 | 6 | 3 | 8 | 1.3 | CC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2ccccc2)N(C)C(=O)[C@@H]2CCC(=O)NN2C(=O)[C@H]2CCC=NN2C1=O | 10.1021/jm00171a003 | |||
| 44275233 | 199134 | 0 | None | 3 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 521 | 6 | 0 | 6 | 3.8 | COc1cc(OC2CCN(C(C)=O)CC2)ccc1CC(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| CHEMBL279230 | 199134 | 0 | None | 3 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 521 | 6 | 0 | 6 | 3.8 | COc1cc(OC2CCN(C(C)=O)CC2)ccc1CC(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(99)00181-x | |||
| 11756466 | 19427 | 0 | None | -1 | 2 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 521 | 6 | 0 | 6 | 4.4 | COc1cc(O[C@H](C)c2cc[n+]([O-])cc2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| CHEMBL105514 | 19427 | 0 | None | -1 | 2 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 521 | 6 | 0 | 6 | 4.4 | COc1cc(O[C@H](C)c2cc[n+]([O-])cc2)c(F)cc1C(=O)N1CCC(N2C(=O)OCc3ccccc32)CC1 | 10.1016/s0960-894x(98)00568-x | |||
| 1103932 | 40883 | 8 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 434 | 6 | 2 | 5 | 2.4 | O=C(CN(c1ccccc1)S(=O)(=O)c1ccccc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm050645f | |||
| CHEMBL1254116 | 40883 | 8 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 434 | 6 | 2 | 5 | 2.4 | O=C(CN(c1ccccc1)S(=O)(=O)c1ccccc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm050645f | |||
| 1103932 | 40883 | 8 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 434 | 6 | 2 | 5 | 2.4 | O=C(CN(c1ccccc1)S(=O)(=O)c1ccccc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm901812z | |||
| CHEMBL1254116 | 40883 | 8 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 434 | 6 | 2 | 5 | 2.4 | O=C(CN(c1ccccc1)S(=O)(=O)c1ccccc1)N/N=C1\C(=O)Nc2ccccc21 | 10.1021/jm901812z | |||
| CHEMBL2369831 | 477593 | 1 | None | -91 | 4 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 1041 | 17 | 13 | 15 | -4.2 | C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm030611c | |||
| 1368921 | 145113 | 6 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 428 | 6 | 1 | 3 | 4.8 | Cc1ccc(N(CC(=O)Nc2cccc(Cl)c2C)S(=O)(=O)c2ccccc2)cc1 | 10.1021/jm050645f | |||
| CHEMBL200415 | 145113 | 6 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 428 | 6 | 1 | 3 | 4.8 | Cc1ccc(N(CC(=O)Nc2cccc(Cl)c2C)S(=O)(=O)c2ccccc2)cc1 | 10.1021/jm050645f | |||
| 52947354 | 40875 | 11 | None | 2 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 338 | 4 | 1 | 4 | 2.9 | CO/N=C1/C[C@@H](CO)N(C(=O)c2ccc(-c3ccccc3C)cc2)C1 | 10.1021/jm901812z | |||
| CHEMBL1254025 | 40875 | 11 | None | 2 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 338 | 4 | 1 | 4 | 2.9 | CO/N=C1/C[C@@H](CO)N(C(=O)c2ccc(-c3ccccc3C)cc2)C1 | 10.1021/jm901812z | |||
| DB16259 | 40875 | 11 | None | 2 | 3 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 338 | 4 | 1 | 4 | 2.9 | CO/N=C1/C[C@@H](CO)N(C(=O)c2ccc(-c3ccccc3C)cc2)C1 | 10.1021/jm901812z | |||
| 54580303 | 125812 | 0 | None | -6 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 1558 | 24 | 17 | 23 | 0.3 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)C(O)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)c2ccc(-c3c4ccc(=N)c(S(=O)(=O)O)c-4oc4c(S(=O)(=O)O)c(N)ccc34)c(C(=O)O)c2)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm1016208 | |||
| CHEMBL1789152 | 125812 | 0 | None | -6 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 1558 | 24 | 17 | 23 | 0.3 | CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)C(O)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCNC(=O)c2ccc(-c3c4ccc(=N)c(S(=O)(=O)O)c-4oc4c(S(=O)(=O)O)c(N)ccc34)c(C(=O)O)c2)C(=O)NCC(=O)O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm1016208 | |||
| 135506374 | 275287 | 21 | None | -3 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL3763342 | 275287 | 21 | None | -3 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 581 | 5 | 4 | 8 | 4.1 | Cc1cc(C(=O)N2Cc3cnn(C)c3Nc3ccccc32)ccc1CNC(=O)N1CCN(Cc2cc(O)cc(O)c2)CC1 | 10.1021/acs.jmedchem.8b00697 | |||
| CHEMBL3814232 | 487601 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 1034 | 18 | 11 | 15 | -3.0 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](NC)CSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)N(C)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | 10.1016/j.bmc.2016.05.062 | |||
| 11366713 | 274628 | 0 | None | -2238 | 8 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 1054 | 19 | 13 | 15 | -3.9 | NCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| CHEMBL375096 | 274628 | 0 | None | -2238 | 8 | Rat | 6.0 | pKi | = | 6 | Binding | ChEMBL | 1054 | 19 | 13 | 15 | -3.9 | NCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O | 10.1021/jm060928n | |||
| 3484 | 7856 | 0 | None | None | None | Human | 10.4 | pKd | = | 10.4 | Binding | Guide to Pharmacology | 626 | 8 | 0 | 6 | 3.9 | O=C(N1CCC(CC1)N1C(=O)CCc2c1cccc2)Cc1ccc(cc1OCC(F)(F)F)OC1CCN(CC1)[35S](=O)(=O)C | 12176104 | |||
| 73755057 | 7856 | 0 | None | None | None | Human | 10.4 | pKd | = | 10.4 | Binding | Guide to Pharmacology | 626 | 8 | 0 | 6 | 3.9 | O=C(N1CCC(CC1)N1C(=O)CCc2c1cccc2)Cc1ccc(cc1OCC(F)(F)F)OC1CCN(CC1)[35S](=O)(=O)C | 12176104 | |||
| 3756 | 7534 | 0 | None | None | None | Human | 8.3 | pKd | = | 8.3 | Binding | Guide to Pharmacology | None | None | None | None | 12942128 | |||||
| 2042 | 8014 | 41 | None | 40 | 4 | Human | 8.9 | pKd | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 6278592 | |||
| 2042 | 8014 | 41 | None | 40 | 4 | Human | 8.9 | pKd | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7475979 | |||
| 2042 | 8014 | 41 | None | 40 | 4 | Human | 8.9 | pKd | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7774575 | |||
| 2042 | 8014 | 41 | None | 40 | 4 | Human | 8.9 | pKd | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7921228 | |||
| 2176 | 8014 | 41 | None | 40 | 4 | Human | 8.9 | pKd | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 6278592 | |||
| 2176 | 8014 | 41 | None | 40 | 4 | Human | 8.9 | pKd | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7475979 | |||
| 2176 | 8014 | 41 | None | 40 | 4 | Human | 8.9 | pKd | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7774575 | |||
| 2176 | 8014 | 41 | None | 40 | 4 | Human | 8.9 | pKd | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7921228 | |||
| 439302 | 8014 | 41 | None | 40 | 4 | Human | 8.9 | pKd | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 6278592 | |||
| 439302 | 8014 | 41 | None | 40 | 4 | Human | 8.9 | pKd | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7475979 | |||
| 439302 | 8014 | 41 | None | 40 | 4 | Human | 8.9 | pKd | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7774575 | |||
| 439302 | 8014 | 41 | None | 40 | 4 | Human | 8.9 | pKd | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7921228 | |||
| CHEMBL395429 | 8014 | 41 | None | 40 | 4 | Human | 8.9 | pKd | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 6278592 | |||
| CHEMBL395429 | 8014 | 41 | None | 40 | 4 | Human | 8.9 | pKd | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7475979 | |||
| CHEMBL395429 | 8014 | 41 | None | 40 | 4 | Human | 8.9 | pKd | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7774575 | |||
| CHEMBL395429 | 8014 | 41 | None | 40 | 4 | Human | 8.9 | pKd | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7921228 | |||
| 3778 | 7644 | 0 | None | None | None | Human | 10.0 | pKd | None | 10 | Binding | Guide to Pharmacology | None | None | None | None | None | |||||
| 10124389 | 7880 | 0 | None | -3 | 5 | Human | 8.9 | pKd | None | 8.9 | Binding | Guide to Pharmacology | 1085 | 31 | 16 | 16 | -5.9 | NC(=O)CC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O | 11337500 | |||
| 10124389 | 7880 | 0 | None | -3 | 5 | Human | 8.9 | pKd | None | 8.9 | Binding | Guide to Pharmacology | 1085 | 31 | 16 | 16 | -5.9 | NC(=O)CC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O | 7774575 | |||
| 2175 | 7880 | 0 | None | -3 | 5 | Human | 8.9 | pKd | None | 8.9 | Binding | Guide to Pharmacology | 1085 | 31 | 16 | 16 | -5.9 | NC(=O)CC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O | 11337500 | |||
| 2175 | 7880 | 0 | None | -3 | 5 | Human | 8.9 | pKd | None | 8.9 | Binding | Guide to Pharmacology | 1085 | 31 | 16 | 16 | -5.9 | NC(=O)CC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O | 7774575 | |||
| 2218 | 2789 | 0 | None | 1 | 2 | Human | 9.6 | pKd | None | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 11337500 | |||||
| 2220 | 2791 | 0 | None | 7 | 2 | Human | 9.9 | pKd | None | 9.9 | Binding | Guide to Pharmacology | None | None | None | None | 11337500 | |||||
| 2220 | 2791 | 0 | None | 7 | 2 | Human | 9.9 | pKd | None | 9.9 | Binding | Guide to Pharmacology | None | None | None | None | 7774575 | |||||
| 2220 | 2791 | 0 | None | 7 | 2 | Human | 9.9 | pKd | None | 9.9 | Binding | Guide to Pharmacology | None | None | None | None | 8955347 | |||||
| 119369 | 5304 | 49 | None | -5 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 427 | 4 | 1 | 3 | 5.3 | O=C(N1CCCC(c2c1cccc2)N(C)C)c1ccc(cc1)NC(=O)c1ccccc1C | None | |||
| 2197 | 5304 | 49 | None | -5 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 427 | 4 | 1 | 3 | 5.3 | O=C(N1CCCC(c2c1cccc2)N(C)C)c1ccc(cc1)NC(=O)c1ccccc1C | None | |||
| 4004 | 5304 | 49 | None | -5 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 427 | 4 | 1 | 3 | 5.3 | O=C(N1CCCC(c2c1cccc2)N(C)C)c1ccc(cc1)NC(=O)c1ccccc1C | None | |||
| CHEMBL420762 | 5304 | 49 | None | -5 | 6 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 427 | 4 | 1 | 3 | 5.3 | O=C(N1CCCC(c2c1cccc2)N(C)C)c1ccc(cc1)NC(=O)c1ccccc1C | None | |||
| 151171 | 2408 | 36 | None | -19 | 5 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 498 | 4 | 2 | 3 | 6.5 | Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 | None | |||
| 2203 | 2408 | 36 | None | -19 | 5 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 498 | 4 | 2 | 3 | 6.5 | Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 | None | |||
| 732 | 2408 | 36 | None | -19 | 5 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 498 | 4 | 2 | 3 | 6.5 | Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 | None | |||
| CHEMBL1755 | 2408 | 36 | None | -19 | 5 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 498 | 4 | 2 | 3 | 6.5 | Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 | None | |||
| DB00872 | 2408 | 36 | None | -19 | 5 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 498 | 4 | 2 | 3 | 6.5 | Cc1[nH]c2c(n1)c1ccccc1N(CC2)C(=O)c1ccc(cc1)NC(=O)c1ccccc1c1ccccc1 | None | |||
| 2213 | 1072 | 37 | None | -20 | 5 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | None | |||
| 3008 | 1072 | 37 | None | -20 | 5 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | None | |||
| 5311010 | 1072 | 37 | None | -20 | 5 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | None | |||
| 68613 | 1072 | 37 | None | -20 | 5 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | None | |||
| CHEMBL378642 | 1072 | 37 | None | -20 | 5 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | None | |||
| CHEMBL382301 | 1072 | 37 | None | -20 | 5 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | None | |||
| DB09059 | 1072 | 37 | None | -20 | 5 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | None | |||
| 5311065 | 484177 | 30 | None | -4 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | None | |||
| 817 | 484177 | 30 | None | -4 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | None | |||
| CHEMBL1429 | 484177 | 30 | None | -4 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | None | |||
| DB00035 | 484177 | 30 | None | -4 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | None | |||
| 2213 | 1072 | 37 | None | -22 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | None | |||
| 3008 | 1072 | 37 | None | -22 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | None | |||
| 5311010 | 1072 | 37 | None | -22 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | None | |||
| 68613 | 1072 | 37 | None | -22 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | None | |||
| CHEMBL378642 | 1072 | 37 | None | -22 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | None | |||
| CHEMBL382301 | 1072 | 37 | None | -22 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | None | |||
| DB09059 | 1072 | 37 | None | -22 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | None | |||
| 11169 | 1650 | 39 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | None | |||
| 165708555 | 1650 | 39 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | None | |||
| 16681432 | 1650 | 39 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | None | |||
| 495 | 1650 | 39 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | None | |||
| CHEMBL3301668 | 1650 | 39 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | None | |||
| DB01282 | 1650 | 39 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 987 | 18 | 10 | 13 | -2.5 | CC[C@@H]([C@@H]1NC(=O)[C@@H](NC(=O)CCCSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)Cc1ccc(cc1)OC)C | None | |||
| 146681949 | 8624 | 35 | None | -5 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | None | |||
| 2168 | 8624 | 35 | None | -5 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | None | |||
| 2810 | 8624 | 35 | None | -5 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | None | |||
| 644077 | 8624 | 35 | None | -5 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | None | |||
| CHEMBL373742 | 8624 | 35 | None | -5 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | None | |||
| DB00067 | 8624 | 35 | None | -5 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | None | |||
| P01185 | 8624 | 35 | None | -5 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | None | |||
| P01186 | 8624 | 35 | None | -5 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | None | |||
| P35455 | 8624 | 35 | None | -5 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | None | |||
| 146681949 | 8624 | 35 | None | -4 | 8 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | None | |||
| 2168 | 8624 | 35 | None | -4 | 8 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | None | |||
| 2810 | 8624 | 35 | None | -4 | 8 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | None | |||
| 644077 | 8624 | 35 | None | -4 | 8 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | None | |||
| CHEMBL373742 | 8624 | 35 | None | -4 | 8 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | None | |||
| DB00067 | 8624 | 35 | None | -4 | 8 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | None | |||
| P01185 | 8624 | 35 | None | -4 | 8 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | None | |||
| P01186 | 8624 | 35 | None | -4 | 8 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | None | |||
| P35455 | 8624 | 35 | None | -4 | 8 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | None | |||
| 5311065 | 484177 | 30 | None | -2 | 8 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | None | |||
| 817 | 484177 | 30 | None | -2 | 8 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | None | |||
| CHEMBL1429 | 484177 | 30 | None | -2 | 8 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | None | |||
| DB00035 | 484177 | 30 | None | -2 | 8 | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 1068 | 19 | 14 | 15 | -4.1 | N=C(N)NCCC[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1)C(=O)NCC(N)=O | None | |||
| 3126 | 484342 | 1 | None | None | None | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 991 | 17 | 11 | 14 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | None | |||
| CHEMBL435716 | 484342 | 1 | None | None | None | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 991 | 17 | 11 | 14 | -2.5 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)CCSSC[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O | None | |||
| 2042 | 6074 | 0 | None | -1 | 7 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | None | |||
| 2174 | 6074 | 0 | None | -1 | 7 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | None | |||
| 439302 | 6074 | 0 | None | -1 | 7 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | None | |||
| CHEMBL395429 | 6074 | 0 | None | -1 | 7 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | None | |||
| DB00107 | 6074 | 0 | None | -1 | 7 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | None | |||
| P01178 | 6074 | 0 | None | -1 | 7 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | None | |||
| P01179 | 6074 | 0 | None | -1 | 7 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | None | |||
| P35454 | 6074 | 0 | None | -1 | 7 | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | None | |||
| 2042 | 6074 | 0 | None | 1 | 7 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | None | |||
| 2174 | 6074 | 0 | None | 1 | 7 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | None | |||
| 439302 | 6074 | 0 | None | 1 | 7 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | None | |||
| CHEMBL395429 | 6074 | 0 | None | 1 | 7 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | None | |||
| DB00107 | 6074 | 0 | None | 1 | 7 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | None | |||
| P01178 | 6074 | 0 | None | 1 | 7 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | None | |||
| P01179 | 6074 | 0 | None | 1 | 7 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | None | |||
| P35454 | 6074 | 0 | None | 1 | 7 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | None | |||
| 10444 | 4740 | 20 | None | 5 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 531 | 4 | 2 | 6 | 4.2 | Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C | 30199637 | |||
| 145711714 | 4740 | 20 | None | 5 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 531 | 4 | 2 | 6 | 4.2 | Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C | 30199637 | |||
| CHEMBL4204210 | 4740 | 20 | None | 5 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 531 | 4 | 2 | 6 | 4.2 | Cc1c(ccc(c1)C(=O)N1Cc2c(Nc3ccccc13)n(nc2)C)CNC(=O)N1CCC[C@H]1C(=S)N(C)C | 30199637 | |||
| 8529 | 6823 | 0 | None | -10000 | 3 | Human | 5.0 | pKi | = | 5 | Binding | Guide to Pharmacology | 439 | 4 | 0 | 4 | 3.9 | CN(CCN1CC(c2c1cc(Cl)cc2)C(=O)N1CCC2(CC1)OCc1c2cccc1)C | 25654260 | |||
| 91827367 | 6823 | 0 | None | -10000 | 3 | Human | 5.0 | pKi | = | 5 | Binding | Guide to Pharmacology | 439 | 4 | 0 | 4 | 3.9 | CN(CCN1CC(c2c1cc(Cl)cc2)C(=O)N1CCC2(CC1)OCc1c2cccc1)C | 25654260 | |||
| 10615 | 1182 | 36 | None | -10000 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | Guide to Pharmacology | 409 | 3 | 0 | 6 | 4.4 | CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 | 31951127 | |||
| 46200932 | 1182 | 36 | None | -10000 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | Guide to Pharmacology | 409 | 3 | 0 | 6 | 4.4 | CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 | 31951127 | |||
| CHEMBL4297183 | 1182 | 36 | None | -10000 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | Guide to Pharmacology | 409 | 3 | 0 | 6 | 4.4 | CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 | 31951127 | |||
| DB14823 | 1182 | 36 | None | -10000 | 3 | Human | 5.2 | pKi | = | 5.2 | Binding | Guide to Pharmacology | 409 | 3 | 0 | 6 | 4.4 | CN1Cc2cc(Cl)ccc2n2c(C1)nnc2[C@@H]1CC[C@H](CC1)Oc1ccccn1 | 31951127 | |||
| 2179 | 8306 | 0 | None | 44 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 939 | 28 | 14 | 15 | -4.8 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)CS)CC(=O)N)[C@H](O)C)NC(=O)[C@@H](NC(=O)[C@H](C=S)N)Cc1ccc(cc1)O)C | 23723434 | |||
| 2179 | 8306 | 0 | None | 44 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 939 | 28 | 14 | 15 | -4.8 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)CS)CC(=O)N)[C@H](O)C)NC(=O)[C@@H](NC(=O)[C@H](C=S)N)Cc1ccc(cc1)O)C | 2827511 | |||
| 2179 | 8306 | 0 | None | 44 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 939 | 28 | 14 | 15 | -4.8 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)CS)CC(=O)N)[C@H](O)C)NC(=O)[C@@H](NC(=O)[C@H](C=S)N)Cc1ccc(cc1)O)C | 7475979 | |||
| 2179 | 8306 | 0 | None | 44 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 939 | 28 | 14 | 15 | -4.8 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)CS)CC(=O)N)[C@H](O)C)NC(=O)[C@@H](NC(=O)[C@H](C=S)N)Cc1ccc(cc1)O)C | 8955347 | |||
| 3080871 | 8306 | 0 | None | 44 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 939 | 28 | 14 | 15 | -4.8 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)CS)CC(=O)N)[C@H](O)C)NC(=O)[C@@H](NC(=O)[C@H](C=S)N)Cc1ccc(cc1)O)C | 23723434 | |||
| 3080871 | 8306 | 0 | None | 44 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 939 | 28 | 14 | 15 | -4.8 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)CS)CC(=O)N)[C@H](O)C)NC(=O)[C@@H](NC(=O)[C@H](C=S)N)Cc1ccc(cc1)O)C | 2827511 | |||
| 3080871 | 8306 | 0 | None | 44 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 939 | 28 | 14 | 15 | -4.8 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)CS)CC(=O)N)[C@H](O)C)NC(=O)[C@@H](NC(=O)[C@H](C=S)N)Cc1ccc(cc1)O)C | 7475979 | |||
| 3080871 | 8306 | 0 | None | 44 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 939 | 28 | 14 | 15 | -4.8 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)CS)CC(=O)N)[C@H](O)C)NC(=O)[C@@H](NC(=O)[C@H](C=S)N)Cc1ccc(cc1)O)C | 8955347 | |||
| 2253 | 4548 | 22 | None | -5 | 6 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 586 | 7 | 0 | 7 | 4.4 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)Cc1ccc[n+](c1C)[O-] | 9622556 | |||
| 5311202 | 4548 | 22 | None | -5 | 6 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 586 | 7 | 0 | 7 | 4.4 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)Cc1ccc[n+](c1C)[O-] | 9622556 | |||
| CHEMBL306645 | 4548 | 22 | None | -5 | 6 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 586 | 7 | 0 | 7 | 4.4 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)Cc1ccc[n+](c1C)[O-] | 9622556 | |||
| 3870 | 2853 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | None | |||||
| 2252 | 4546 | 39 | None | -1 | 5 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 16158071 | |||
| 6918320 | 4546 | 39 | None | -1 | 5 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 16158071 | |||
| CHEMBL24781 | 4546 | 39 | None | -1 | 5 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 507 | 5 | 0 | 6 | 3.8 | COc1cc(ccc1C(=O)N1CCC(CC1)N1C(=O)OCc2c1cccc2)OC1CCN(CC1)C(=O)C | 16158071 | |||
| 2042 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10519430 | |||
| 2042 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 12660315 | |||
| 2042 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 16158071 | |||
| 2042 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7475979 | |||
| 2042 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7774575 | |||
| 2042 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 8955347 | |||
| 2174 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10519430 | |||
| 2174 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 12660315 | |||
| 2174 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 16158071 | |||
| 2174 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7475979 | |||
| 2174 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7774575 | |||
| 2174 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 8955347 | |||
| 439302 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10519430 | |||
| 439302 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 12660315 | |||
| 439302 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 16158071 | |||
| 439302 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7475979 | |||
| 439302 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7774575 | |||
| 439302 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 8955347 | |||
| CHEMBL395429 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10519430 | |||
| CHEMBL395429 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 12660315 | |||
| CHEMBL395429 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 16158071 | |||
| CHEMBL395429 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7475979 | |||
| CHEMBL395429 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7774575 | |||
| CHEMBL395429 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 8955347 | |||
| DB00107 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10519430 | |||
| DB00107 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 12660315 | |||
| DB00107 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 16158071 | |||
| DB00107 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7475979 | |||
| DB00107 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7774575 | |||
| DB00107 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 8955347 | |||
| P01178 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10519430 | |||
| P01178 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 12660315 | |||
| P01178 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 16158071 | |||
| P01178 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7475979 | |||
| P01178 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7774575 | |||
| P01178 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 8955347 | |||
| P01179 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10519430 | |||
| P01179 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 12660315 | |||
| P01179 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 16158071 | |||
| P01179 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7475979 | |||
| P01179 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7774575 | |||
| P01179 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 8955347 | |||
| P35454 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 10519430 | |||
| P35454 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 12660315 | |||
| P35454 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 16158071 | |||
| P35454 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7475979 | |||
| P35454 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 7774575 | |||
| P35454 | 6074 | 0 | None | 1 | 7 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 8955347 | |||
| 10461270 | 7472 | 18 | None | 2 | 5 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 603 | 9 | 0 | 5 | 6.9 | CCN(C(=O)c1ccc(c(c1)[C@@]1(C)c2cc(Cl)ccc2N(C1=O)Cc1ccc(cc1OC)OC)Cl)Cc1cccnc1 | 14722330 | |||
| 2201 | 7472 | 18 | None | 2 | 5 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 603 | 9 | 0 | 5 | 6.9 | CCN(C(=O)c1ccc(c(c1)[C@@]1(C)c2cc(Cl)ccc2N(C1=O)Cc1ccc(cc1OC)OC)Cl)Cc1cccnc1 | 14722330 | |||
| CHEMBL1615640 | 7472 | 18 | None | 2 | 5 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 603 | 9 | 0 | 5 | 6.9 | CCN(C(=O)c1ccc(c(c1)[C@@]1(C)c2cc(Cl)ccc2N(C1=O)Cc1ccc(cc1OC)OC)Cl)Cc1cccnc1 | 14722330 | |||
| 11340891 | 6755 | 33 | None | 891 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 17395790 | |||
| 11340891 | 6755 | 33 | None | 891 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 18032036 | |||
| 8403 | 6755 | 33 | None | 891 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 17395790 | |||
| 8403 | 6755 | 33 | None | 891 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 18032036 | |||
| CHEMBL429736 | 6755 | 33 | None | 891 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 17395790 | |||
| CHEMBL429736 | 6755 | 33 | None | 891 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 18032036 | |||
| DB11818 | 6755 | 33 | None | 891 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 17395790 | |||
| DB11818 | 6755 | 33 | None | 891 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 494 | 6 | 1 | 6 | 2.0 | CC[C@@H]([C@@H]1C(=O)N[C@@H](C(=O)N1[C@@H](C(=O)N1CCOCC1)c1coc(n1)C)C1Cc2c(C1)cccc2)C | 18032036 | |||
| 2169 | 963 | 0 | None | 7 | 5 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 1049 | 19 | 14 | 16 | -5.6 | CC[C@@H](C1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCCC1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)C | 7774575 | |||
| 2169 | 963 | 0 | None | 7 | 5 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 1049 | 19 | 14 | 16 | -5.6 | CC[C@@H](C1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCCC1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)C | 8955347 | |||
| 68649 | 963 | 0 | None | 7 | 5 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 1049 | 19 | 14 | 16 | -5.6 | CC[C@@H](C1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCCC1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)C | 7774575 | |||
| 68649 | 963 | 0 | None | 7 | 5 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 1049 | 19 | 14 | 16 | -5.6 | CC[C@@H](C1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCCC1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)C | 8955347 | |||
| 2188 | 2768 | 0 | None | -316 | 4 | Rat | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | None | None | None | None | 17300166 | |||||
| 2186 | 2766 | 0 | None | -501 | 4 | Rat | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | None | None | None | None | 17300166 | |||||
| 2242 | 4526 | 0 | None | None | None | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 459 | 5 | 2 | 4 | 3.4 | OC(=O)CC1(O)CC2C(C1(CC2)CS(=O)(=O)N1CCC2(CC1)C=Cc1c2cccc1)(C)C | 7475979 | |||
| 3083288 | 4526 | 0 | None | None | None | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 459 | 5 | 2 | 4 | 3.4 | OC(=O)CC1(O)CC2C(C1(CC2)CS(=O)(=O)N1CCC2(CC1)C=Cc1c2cccc1)(C)C | 7475979 | |||
| 2190 | 2975 | 0 | None | -398 | 4 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | None | None | None | None | 15084136 | |||||
| 2200 | 6732 | 0 | None | -89 | 4 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 619 | 7 | 2 | 7 | 3.3 | COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl | 10519430 | |||
| 2200 | 6732 | 0 | None | -89 | 4 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 619 | 7 | 2 | 7 | 3.3 | COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl | 16158071 | |||
| 60943 | 6732 | 0 | None | -89 | 4 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 619 | 7 | 2 | 7 | 3.3 | COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl | 10519430 | |||
| 60943 | 6732 | 0 | None | -89 | 4 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 619 | 7 | 2 | 7 | 3.3 | COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl | 16158071 | |||
| CHEMBL419667 | 6732 | 0 | None | -89 | 4 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 619 | 7 | 2 | 7 | 3.3 | COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl | 10519430 | |||
| CHEMBL419667 | 6732 | 0 | None | -89 | 4 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 619 | 7 | 2 | 7 | 3.3 | COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl | 16158071 | |||
| DB13929 | 6732 | 0 | None | -89 | 4 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 619 | 7 | 2 | 7 | 3.3 | COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl | 10519430 | |||
| DB13929 | 6732 | 0 | None | -89 | 4 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 619 | 7 | 2 | 7 | 3.3 | COc1ccc(cc1OC)S(=O)(=O)N1c2ccc(cc2[C@]([C@@H]1C(=O)N1CCC[C@H]1C(=O)N)(O)c1ccccc1Cl)Cl | 16158071 | |||
| 2213 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10519430 | |||
| 2213 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 12660315 | |||
| 2213 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 14722330 | |||
| 2213 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 15880385 | |||
| 2213 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 7475979 | |||
| 3008 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10519430 | |||
| 3008 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 12660315 | |||
| 3008 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 14722330 | |||
| 3008 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 15880385 | |||
| 3008 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 7475979 | |||
| 5311010 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10519430 | |||
| 5311010 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 12660315 | |||
| 5311010 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 14722330 | |||
| 5311010 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 15880385 | |||
| 5311010 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 7475979 | |||
| 68613 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10519430 | |||
| 68613 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 12660315 | |||
| 68613 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 14722330 | |||
| 68613 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 15880385 | |||
| 68613 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 7475979 | |||
| CHEMBL378642 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10519430 | |||
| CHEMBL378642 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 12660315 | |||
| CHEMBL378642 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 14722330 | |||
| CHEMBL378642 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 15880385 | |||
| CHEMBL378642 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 7475979 | |||
| CHEMBL382301 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10519430 | |||
| CHEMBL382301 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 12660315 | |||
| CHEMBL382301 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 14722330 | |||
| CHEMBL382301 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 15880385 | |||
| CHEMBL382301 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 7475979 | |||
| DB09059 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 10519430 | |||
| DB09059 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 12660315 | |||
| DB09059 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 14722330 | |||
| DB09059 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 15880385 | |||
| DB09059 | 1072 | 37 | None | -22 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 7475979 | |||
| 114904 | 6013 | 43 | None | -5 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 449 | 7 | 1 | 4 | 3.2 | CC(=O)NCCCOc1ccc(cc1)C(=O)N1CCC(CC1)N1C(=O)CCc2c1cccc2 | 7475979 | |||
| 2196 | 6013 | 43 | None | -5 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 449 | 7 | 1 | 4 | 3.2 | CC(=O)NCCCOc1ccc(cc1)C(=O)N1CCC(CC1)N1C(=O)CCc2c1cccc2 | 7475979 | |||
| CHEMBL296908 | 6013 | 43 | None | -5 | 5 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 449 | 7 | 1 | 4 | 3.2 | CC(=O)NCCCOc1ccc(cc1)C(=O)N1CCC(CC1)N1C(=O)CCc2c1cccc2 | 7475979 | |||
| 2189 | 2977 | 0 | None | -316 | 4 | Rat | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | None | None | None | None | 17300166 | |||||
| 2192 | 4802 | 27 | None | -5 | 3 | Rat | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 471 | 7 | 2 | 5 | 3.7 | CO/N=C/1\CN([C@@H](C1)C(=O)NC[C@H](c1ccccc1)O)C(=O)c1ccc(cc1)c1ccccc1C | 12660315 | |||
| 9690136 | 4802 | 27 | None | -5 | 3 | Rat | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 471 | 7 | 2 | 5 | 3.7 | CO/N=C/1\CN([C@@H](C1)C(=O)NC[C@H](c1ccccc1)O)C(=O)c1ccc(cc1)c1ccccc1C | 12660315 | |||
| CHEMBL1254024 | 4802 | 27 | None | -5 | 3 | Rat | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 471 | 7 | 2 | 5 | 3.7 | CO/N=C/1\CN([C@@H](C1)C(=O)NC[C@H](c1ccccc1)O)C(=O)c1ccc(cc1)c1ccccc1C | 12660315 | |||
| 2213 | 1072 | 37 | None | -20 | 5 | Rat | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 12660315 | |||
| 3008 | 1072 | 37 | None | -20 | 5 | Rat | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 12660315 | |||
| 5311010 | 1072 | 37 | None | -20 | 5 | Rat | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 12660315 | |||
| 68613 | 1072 | 37 | None | -20 | 5 | Rat | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 12660315 | |||
| CHEMBL378642 | 1072 | 37 | None | -20 | 5 | Rat | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 12660315 | |||
| CHEMBL382301 | 1072 | 37 | None | -20 | 5 | Rat | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 12660315 | |||
| DB09059 | 1072 | 37 | None | -20 | 5 | Rat | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 993 | 18 | 11 | 15 | -3.0 | NCCC[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSCCC(=O)N[C@H](Cc2ccc(cc2)OCC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)[C@H](O)C)[C@H](CC)C | 12660315 | |||
| 16051933 | 2746 | 7 | None | -9 | 7 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 7475979 | |||
| 16051933 | 2746 | 7 | None | -9 | 7 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 7774575 | |||
| 2181 | 2746 | 7 | None | -9 | 7 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 7475979 | |||
| 2181 | 2746 | 7 | None | -9 | 7 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 7774575 | |||
| 2182 | 2746 | 7 | None | -9 | 7 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 7475979 | |||
| 2182 | 2746 | 7 | None | -9 | 7 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 7774575 | |||
| 27991 | 2746 | 7 | None | -9 | 7 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 7475979 | |||
| 27991 | 2746 | 7 | None | -9 | 7 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 7774575 | |||
| 46783812 | 2746 | 7 | None | -9 | 7 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 7475979 | |||
| 46783812 | 2746 | 7 | None | -9 | 7 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 7774575 | |||
| CHEMBL264448 | 2746 | 7 | None | -9 | 7 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 7475979 | |||
| CHEMBL264448 | 2746 | 7 | None | -9 | 7 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 7774575 | |||
| CHEMBL376685 | 2746 | 7 | None | -9 | 7 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 7475979 | |||
| CHEMBL376685 | 2746 | 7 | None | -9 | 7 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 7774575 | |||
| DB00035 | 2746 | 7 | None | -9 | 7 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 7475979 | |||
| DB00035 | 2746 | 7 | None | -9 | 7 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 7774575 | |||
| 2191 | 2979 | 0 | None | -398 | 4 | Rat | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | None | None | None | None | 17300166 | |||||
| 2187 | 2764 | 0 | None | -89 | 4 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | None | None | None | None | 12446593 | |||||
| 2187 | 2764 | 0 | None | -89 | 4 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | None | None | None | None | 16158071 | |||||
| 10413997 | 4534 | 5 | None | -1 | 2 | Human | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | 510 | 6 | 2 | 4 | 3.6 | O=C(Cc1cnc[nH]1)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCC2(CC1)CCc1c2cccc1)(C)C | 7475979 | |||
| 2246 | 4534 | 5 | None | -1 | 2 | Human | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | 510 | 6 | 2 | 4 | 3.6 | O=C(Cc1cnc[nH]1)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCC2(CC1)CCc1c2cccc1)(C)C | 7475979 | |||
| CHEMBL338522 | 4534 | 5 | None | -1 | 2 | Human | 7.6 | pKi | None | 7.6 | Binding | Guide to Pharmacology | 510 | 6 | 2 | 4 | 3.6 | O=C(Cc1cnc[nH]1)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCC2(CC1)CCc1c2cccc1)(C)C | 7475979 | |||
| 2192 | 4802 | 27 | None | 5 | 3 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 471 | 7 | 2 | 5 | 3.7 | CO/N=C/1\CN([C@@H](C1)C(=O)NC[C@H](c1ccccc1)O)C(=O)c1ccc(cc1)c1ccccc1C | 12660315 | |||
| 9690136 | 4802 | 27 | None | 5 | 3 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 471 | 7 | 2 | 5 | 3.7 | CO/N=C/1\CN([C@@H](C1)C(=O)NC[C@H](c1ccccc1)O)C(=O)c1ccc(cc1)c1ccccc1C | 12660315 | |||
| CHEMBL1254024 | 4802 | 27 | None | 5 | 3 | Human | 7.7 | pKi | None | 7.7 | Binding | Guide to Pharmacology | 471 | 7 | 2 | 5 | 3.7 | CO/N=C/1\CN([C@@H](C1)C(=O)NC[C@H](c1ccccc1)O)C(=O)c1ccc(cc1)c1ccccc1C | 12660315 | |||
| 2202 | 5638 | 34 | None | -10 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 11861823 | |||
| 2202 | 5638 | 34 | None | -10 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 16158071 | |||
| 9895468 | 5638 | 34 | None | -10 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 11861823 | |||
| 9895468 | 5638 | 34 | None | -10 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 16158071 | |||
| CHEMBL582857 | 5638 | 34 | None | -10 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 11861823 | |||
| CHEMBL582857 | 5638 | 34 | None | -10 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 16158071 | |||
| DB12643 | 5638 | 34 | None | -10 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 11861823 | |||
| DB12643 | 5638 | 34 | None | -10 | 5 | Human | 7.8 | pKi | None | 7.8 | Binding | Guide to Pharmacology | 629 | 8 | 1 | 9 | 2.9 | COc1cc(OC)ccc1S(=O)(=O)N1c2ccc(cc2[C@@](C1=O)(N1C[C@@H](C[C@H]1C(=O)N(C)C)O)c1ccccc1OC)Cl | 16158071 | |||
| 2247 | 4536 | 0 | None | None | None | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | None | None | None | None | 7475979 | |||||
| 2249 | 4540 | 14 | None | -2 | 7 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 554 | 9 | 2 | 7 | 1.5 | O=C([C@H](CCS(=O)(=O)C)N)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ccccc1C)(C)C | 7475979 | |||
| 9872389 | 4540 | 14 | None | -2 | 7 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 554 | 9 | 2 | 7 | 1.5 | O=C([C@H](CCS(=O)(=O)C)N)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ccccc1C)(C)C | 7475979 | |||
| CHEMBL1253853 | 4540 | 14 | None | -2 | 7 | Human | 8.1 | pKi | None | 8.1 | Binding | Guide to Pharmacology | 554 | 9 | 2 | 7 | 1.5 | O=C([C@H](CCS(=O)(=O)C)N)N[C@H]1C[C@@H]2C([C@]1(CC2)CS(=O)(=O)N1CCN(CC1)c1ccccc1C)(C)C | 7475979 | |||
| 146681949 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10519430 | |||
| 146681949 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 11337500 | |||
| 146681949 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 12446593 | |||
| 146681949 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 15084136 | |||
| 146681949 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 16158071 | |||
| 146681949 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 7475979 | |||
| 146681949 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 7774575 | |||
| 146681949 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 8955347 | |||
| 2168 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10519430 | |||
| 2168 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 11337500 | |||
| 2168 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 12446593 | |||
| 2168 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 15084136 | |||
| 2168 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 16158071 | |||
| 2168 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 7475979 | |||
| 2168 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 7774575 | |||
| 2168 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 8955347 | |||
| 2810 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10519430 | |||
| 2810 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 11337500 | |||
| 2810 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 12446593 | |||
| 2810 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 15084136 | |||
| 2810 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 16158071 | |||
| 2810 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 7475979 | |||
| 2810 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 7774575 | |||
| 2810 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 8955347 | |||
| 644077 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10519430 | |||
| 644077 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 11337500 | |||
| 644077 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 12446593 | |||
| 644077 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 15084136 | |||
| 644077 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 16158071 | |||
| 644077 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 7475979 | |||
| 644077 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 7774575 | |||
| 644077 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 8955347 | |||
| CHEMBL373742 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10519430 | |||
| CHEMBL373742 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 11337500 | |||
| CHEMBL373742 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 12446593 | |||
| CHEMBL373742 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 15084136 | |||
| CHEMBL373742 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 16158071 | |||
| CHEMBL373742 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 7475979 | |||
| CHEMBL373742 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 7774575 | |||
| CHEMBL373742 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 8955347 | |||
| DB00067 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10519430 | |||
| DB00067 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 11337500 | |||
| DB00067 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 12446593 | |||
| DB00067 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 15084136 | |||
| DB00067 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 16158071 | |||
| DB00067 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 7475979 | |||
| DB00067 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 7774575 | |||
| DB00067 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 8955347 | |||
| P01185 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10519430 | |||
| P01185 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 11337500 | |||
| P01185 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 12446593 | |||
| P01185 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 15084136 | |||
| P01185 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 16158071 | |||
| P01185 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 7475979 | |||
| P01185 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 7774575 | |||
| P01185 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 8955347 | |||
| P01186 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10519430 | |||
| P01186 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 11337500 | |||
| P01186 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 12446593 | |||
| P01186 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 15084136 | |||
| P01186 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 16158071 | |||
| P01186 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 7475979 | |||
| P01186 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 7774575 | |||
| P01186 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 8955347 | |||
| P35455 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 10519430 | |||
| P35455 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 11337500 | |||
| P35455 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 12446593 | |||
| P35455 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 15084136 | |||
| P35455 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 16158071 | |||
| P35455 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 7475979 | |||
| P35455 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 7774575 | |||
| P35455 | 8624 | 35 | None | -5 | 8 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1083 | 19 | 14 | 16 | -5.4 | NC(=O)C[C@@H]1NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@H](CSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)N | 8955347 | |||
| 16051933 | 2746 | 7 | None | -9 | 7 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 15084136 | |||
| 2181 | 2746 | 7 | None | -9 | 7 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 15084136 | |||
| 2182 | 2746 | 7 | None | -9 | 7 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 15084136 | |||
| 27991 | 2746 | 7 | None | -9 | 7 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 15084136 | |||
| 46783812 | 2746 | 7 | None | -9 | 7 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 15084136 | |||
| CHEMBL264448 | 2746 | 7 | None | -9 | 7 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 15084136 | |||
| CHEMBL376685 | 2746 | 7 | None | -9 | 7 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 15084136 | |||
| DB00035 | 2746 | 7 | None | -9 | 7 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1068 | 19 | 13 | 15 | -4.3 | NC(=O)CC1NC(=O)C(CCC(=O)N)NC(=O)C(Cc2ccccc2)NC(=O)C(NC(=O)CCSSCC(NC1=O)C(=O)N1CCCC1C(=O)NC(C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O | 15084136 | |||
| 2223 | 2784 | 0 | None | -3 | 4 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1151 | 20 | 12 | 15 | -2.3 | COc1ccc(cc1)C[C@H]1NC(=O)CC2(CCCCC2)SSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)Cc1ccccc1)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N | 7475979 | |||
| 6917952 | 2784 | 0 | None | -3 | 4 | Human | 8.3 | pKi | None | 8.3 | Binding | Guide to Pharmacology | 1151 | 20 | 12 | 15 | -2.3 | COc1ccc(cc1)C[C@H]1NC(=O)CC2(CCCCC2)SSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)Cc1ccccc1)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N | 7475979 | |||
| 196819 | 4528 | 0 | None | None | None | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 755 | 14 | 5 | 8 | 1.7 | C=C[C@@H]([C@@H](C(=O)N1CCCC[C@]1(C=O)C(=O)N1CCCCC1)NC(=O)[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1cnc[nH]1)N)C | 7475979 | |||
| 2243 | 4528 | 0 | None | None | None | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | 755 | 14 | 5 | 8 | 1.7 | C=C[C@@H]([C@@H](C(=O)N1CCCC[C@]1(C=O)C(=O)N1CCCCC1)NC(=O)[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1cnc[nH]1)N)C | 7475979 | |||
| 2248 | 4538 | 0 | None | None | None | Human | 8.4 | pKi | None | 8.4 | Binding | Guide to Pharmacology | None | None | None | None | 7475979 | |||||
| 2241 | 4522 | 5 | None | 2 | 4 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 738 | 6 | 2 | 8 | 2.3 | CC[C@@H]([C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](N(C(=O)[C@H]2N(C(=O)[C@@H]3N(C1=O)N=CCC3)N=CCC2)C)Cc1ccccc1)C | 7475979 | |||
| 9810632 | 4522 | 5 | None | 2 | 4 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 738 | 6 | 2 | 8 | 2.3 | CC[C@@H]([C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](N(C(=O)[C@H]2N(C(=O)[C@@H]3N(C1=O)N=CCC3)N=CCC2)C)Cc1ccccc1)C | 7475979 | |||
| CHEMBL127686 | 4522 | 5 | None | 2 | 4 | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | 738 | 6 | 2 | 8 | 2.3 | CC[C@@H]([C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](N(C(=O)[C@H]2N(C(=O)[C@@H]3N(C1=O)N=CCC3)N=CCC2)C)Cc1ccccc1)C | 7475979 | |||
| 2250 | 4542 | 0 | None | None | None | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 7475979 | |||||
| 2251 | 4544 | 0 | None | None | None | Human | 8.5 | pKi | None | 8.5 | Binding | Guide to Pharmacology | None | None | None | None | 7475979 | |||||
| 188397 | 4532 | 0 | None | None | None | Human | 8.6 | pKi | None | 8.6 | Binding | Guide to Pharmacology | 768 | 14 | 3 | 10 | 2.3 | CC[C@@H]([C@@H](C(=O)[C@@]1(C=O)CCCN1C(=O)[C@@H](CC1=NC(N=C1)(C(=O)N1CCCCC1)C(=O)N1CCCCC1)N)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)N)C | 7475979 | |||
| 2245 | 4532 | 0 | None | None | None | Human | 8.6 | pKi | None | 8.6 | Binding | Guide to Pharmacology | 768 | 14 | 3 | 10 | 2.3 | CC[C@@H]([C@@H](C(=O)[C@@]1(C=O)CCCN1C(=O)[C@@H](CC1=NC(N=C1)(C(=O)N1CCCCC1)C(=O)N1CCCCC1)N)NC(=O)[C@H](Cc1ccc2c(c1)cccc2)N)C | 7475979 | |||
| 2042 | 6074 | 0 | None | -1 | 7 | Rat | 8.7 | pKi | None | 8.7 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 12660315 | |||
| 2174 | 6074 | 0 | None | -1 | 7 | Rat | 8.7 | pKi | None | 8.7 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 12660315 | |||
| 439302 | 6074 | 0 | None | -1 | 7 | Rat | 8.7 | pKi | None | 8.7 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 12660315 | |||
| CHEMBL395429 | 6074 | 0 | None | -1 | 7 | Rat | 8.7 | pKi | None | 8.7 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 12660315 | |||
| DB00107 | 6074 | 0 | None | -1 | 7 | Rat | 8.7 | pKi | None | 8.7 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 12660315 | |||
| P01178 | 6074 | 0 | None | -1 | 7 | Rat | 8.7 | pKi | None | 8.7 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 12660315 | |||
| P01179 | 6074 | 0 | None | -1 | 7 | Rat | 8.7 | pKi | None | 8.7 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 12660315 | |||
| P35454 | 6074 | 0 | None | -1 | 7 | Rat | 8.7 | pKi | None | 8.7 | Binding | Guide to Pharmacology | 1006 | 17 | 12 | 15 | -3.6 | CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C | 12660315 | |||
| 164712 | 6321 | 0 | None | 50 | 3 | Human | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 1040 | 17 | 12 | 15 | -3.4 | CC(C[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(cc2)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)CCC(=O)N)Cc1ccccc1)C | 7774575 | |||
| 164712 | 6321 | 0 | None | 50 | 3 | Human | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 1040 | 17 | 12 | 15 | -3.4 | CC(C[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(cc2)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)CCC(=O)N)Cc1ccccc1)C | 8955347 | |||
| 2178 | 6321 | 0 | None | 50 | 3 | Human | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 1040 | 17 | 12 | 15 | -3.4 | CC(C[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(cc2)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)CCC(=O)N)Cc1ccccc1)C | 7774575 | |||
| 2178 | 6321 | 0 | None | 50 | 3 | Human | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 1040 | 17 | 12 | 15 | -3.4 | CC(C[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(cc2)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)CCC(=O)N)Cc1ccccc1)C | 8955347 | |||
| CHEMBL3272682 | 6321 | 0 | None | 50 | 3 | Human | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 1040 | 17 | 12 | 15 | -3.4 | CC(C[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(cc2)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)CCC(=O)N)Cc1ccccc1)C | 7774575 | |||
| CHEMBL3272682 | 6321 | 0 | None | 50 | 3 | Human | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | 1040 | 17 | 12 | 15 | -3.4 | CC(C[C@@H](C(=O)NCC(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](Cc2ccc(cc2)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC(=O)N)CCC(=O)N)Cc1ccccc1)C | 8955347 | |||
| 2239 | 2222 | 0 | None | 501 | 3 | Human | 8.9 | pKi | None | 8.9 | Binding | Guide to Pharmacology | 497 | 7 | 2 | 3 | 3.7 | CC(C[C@@H]1C(=O)N[C@@H](C(=O)N1[C@H](c1ccc(cc1F)F)C(=O)NC(C)C)C1Cc2c(C1)cccc2)C | 16250654 | |||
| 6918854 | 2222 | 0 | None | 501 | 3 | Human | 8.9 | pKi | None | 8.9 | Binding | Guide to Pharmacology | 497 | 7 | 2 | 3 | 3.7 | CC(C[C@@H]1C(=O)N[C@@H](C(=O)N1[C@H](c1ccc(cc1F)F)C(=O)NC(C)C)C1Cc2c(C1)cccc2)C | 16250654 | |||
| CHEMBL196478 | 2222 | 0 | None | 501 | 3 | Human | 8.9 | pKi | None | 8.9 | Binding | Guide to Pharmacology | 497 | 7 | 2 | 3 | 3.7 | CC(C[C@@H]1C(=O)N[C@@H](C(=O)N1[C@H](c1ccc(cc1F)F)C(=O)NC(C)C)C1Cc2c(C1)cccc2)C | 16250654 | |||
| 2219 | 2788 | 0 | None | 1 | 4 | Human | 9.0 | pKi | None | 9 | Binding | Guide to Pharmacology | None | None | None | None | 11337500 | |||||
| 135413562 | 4496 | 12 | None | 1 | 5 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 624 | 14 | 3 | 7 | 1.1 | CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C | 16302826 | |||
| 135413562 | 4496 | 12 | None | -1 | 5 | Rat | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 624 | 14 | 3 | 7 | 1.1 | CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C | 16302826 | |||
| 2194 | 4496 | 12 | None | 1 | 5 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 624 | 14 | 3 | 7 | 1.1 | CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C | 16302826 | |||
| 2194 | 4496 | 12 | None | -1 | 5 | Rat | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 624 | 14 | 3 | 7 | 1.1 | CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C | 16302826 | |||
| CHEMBL445816 | 4496 | 12 | None | 1 | 5 | Human | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 624 | 14 | 3 | 7 | 1.1 | CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C | 16302826 | |||
| CHEMBL445816 | 4496 | 12 | None | -1 | 5 | Rat | 9.2 | pKi | None | 9.2 | Binding | Guide to Pharmacology | 624 | 14 | 3 | 7 | 1.1 | CN(CCCNC(=O)CCc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)Cl)CC(=O)NNC1=c2ccccc2=NC1=O)C | 16302826 | |||
| 2244 | 4530 | 0 | None | None | None | Human | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 7475979 | |||||
| 2221 | 2793 | 0 | None | 17 | 4 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 15880385 | |||||
| 2221 | 2793 | 0 | None | 17 | 4 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | None | None | None | None | 16158071 | |||||