d(CH2)5[Tyr(Me)2]AVP


SMILES COc1ccc(cc1)C[C@H]1NC(=O)CC2(CCCCC2)SSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)Cc1ccccc1)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N
InChIKey QVQOGNOOAMQKCE-OVSZNHMYSA-N
Sequence CYFQNCPRG

Chemical properties

Hydrogen bond acceptors 15
Hydrogen bond donors 12
Rotatable bonds 20
Molecular weight (Da) 1150.5

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
V1A V1AR Human Vasopressin and oxytocin A pKi 8.4 8.8 9.2 Guide to Pharmacology
V2 V2R Human Vasopressin and oxytocin A pKi 6.7 6.9 7.1 Guide to Pharmacology
OT OXYR Human Vasopressin and oxytocin A pKi 8.3 8.3 8.3 Guide to Pharmacology
V1B V1BR Human Vasopressin and oxytocin A pKi 6.4 6.7 7.0 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database