[3H]OT (human, mouse, rat)


SMILES CC[C@@H]([C@@H]1NC(=O)[C@H](Cc2ccc(cc2)O)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCC(=O)N)CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CC(C)C)C
InChIKey XNOPRXBHLZRZKH-DSZYJQQASA-N
Sequence CYIQNCPLG

Chemical properties

Hydrogen bond acceptors 15
Hydrogen bond donors 12
Rotatable bonds 17
Molecular weight (Da) 1006.4

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
V1B V1BR Human Vasopressin and oxytocin A pKd 5.8 5.8 5.8 Guide to Pharmacology
V2 V2R Human Vasopressin and oxytocin A pKd 5.8 5.8 5.8 Guide to Pharmacology
OT OXYR Human Vasopressin and oxytocin A pKd 8.2 8.85 9.5 Guide to Pharmacology
OT OXYR Human Vasopressin and oxytocin A pKd 8.17 8.17 8.17 ChEMBL
OT OXYR Human Vasopressin and oxytocin A pKi 8.02 8.85 9.36 ChEMBL
V1B V1BR Human Vasopressin and oxytocin A pKi 5.75 5.75 5.75 ChEMBL
V2 V2R Human Vasopressin and oxytocin A pKi 5.46 5.63 5.81 ChEMBL
V1A V1AR Human Vasopressin and oxytocin A pKi 6.92 7.25 7.7 ChEMBL
OT OXYR Rat Vasopressin and oxytocin A pKi 8.77 8.91 9.05 ChEMBL
V1A V1AR Human Vasopressin and oxytocin A pKd 6.9 6.9 6.9 Guide to Pharmacology
V2 V2R Rat Vasopressin and oxytocin A pKi 7.06 7.13 7.21 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
OT OXYR Mouse Vasopressin and oxytocin A pEC50 8.7 8.7 8.7 ChEMBL
OT OXYR Human Vasopressin and oxytocin A pIC50 8.57 8.57 8.57 ChEMBL
OT OXYR Human Vasopressin and oxytocin A pEC50 7.58 8.83 11.0 ChEMBL
V1B V1BR Human Vasopressin and oxytocin A pEC50 6.62 7.73 9.7 ChEMBL
V2 V2R Human Vasopressin and oxytocin A pEC50 6.09 7.11 8.14 ChEMBL
V1A V1AR Human Vasopressin and oxytocin A pEC50 6.58 8.28 9.74 ChEMBL