L-365,209


SMILES CC[C@@H]([C@@H]1NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](N(C(=O)[C@H]2N(C(=O)[C@@H]3N(C1=O)N=CCC3)N=CCC2)C)Cc1ccccc1)C
InChIKey IFHSSGUGRIXWQU-NSTWBPGMSA-N
Sequence XXFPFI

Chemical properties

Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 6
Molecular weight (Da) 738.4

Drug properties

Molecular type Peptide
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
OT OXYR Human Vasopressin and oxytocin A pKi 8.5 8.5 8.5 Guide to Pharmacology
V1A V1AR Rat Vasopressin and oxytocin A pKi 6.43 6.43 6.43 ChEMBL
V2 V2R Rat Vasopressin and oxytocin A pKi 6.09 6.18 6.27 ChEMBL
OT OXYR Rat Vasopressin and oxytocin A pKi 8.14 8.14 8.14 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
V1A V1AR Rat Vasopressin and oxytocin A pIC50 5.89 5.89 5.89 ChEMBL
V2 V2R Rat Vasopressin and oxytocin A pIC50 5.64 5.64 5.64 ChEMBL
OT OXYR Rat Vasopressin and oxytocin A pIC50 7.75 7.75 7.75 ChEMBL