Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
AssayType |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 172198 | 866 | 40 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | ||
| 2504 | 866 | 40 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | ||
| 5272 | 866 | 40 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL408403 | 866 | 40 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | ||
| DB11842 | 866 | 40 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | ||
| P01015 | 866 | 40 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | ||
| P01019 | 866 | 40 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | ||
| P11859 | 866 | 40 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | ||
| 172198 | 866 | 40 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | ||
| 2504 | 866 | 40 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | ||
| 5272 | 866 | 40 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL408403 | 866 | 40 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | ||
| DB11842 | 866 | 40 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | ||
| P01015 | 866 | 40 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | ||
| P01019 | 866 | 40 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | ||
| P11859 | 866 | 40 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | ||
| 172198 | 866 | 40 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| 2504 | 866 | 40 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| 5272 | 866 | 40 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| CHEMBL408403 | 866 | 40 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| DB11842 | 866 | 40 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| P01015 | 866 | 40 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| P01019 | 866 | 40 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| P11859 | 866 | 40 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| 172198 | 866 | 40 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| 2504 | 866 | 40 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| 5272 | 866 | 40 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| CHEMBL408403 | 866 | 40 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| DB11842 | 866 | 40 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| P01015 | 866 | 40 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| P01019 | 866 | 40 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| P11859 | 866 | 40 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| 127030943 | 276523 | 0 | None | None | None | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787700 | 276523 | 0 | None | None | None | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| 127030943 | 276523 | 0 | None | None | None | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787700 | 276523 | 0 | None | None | None | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| 172198 | 866 | 40 | None | -1 | 2 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | ||
| 2504 | 866 | 40 | None | -1 | 2 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | ||
| 5272 | 866 | 40 | None | -1 | 2 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | ||
| CHEMBL408403 | 866 | 40 | None | -1 | 2 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | ||
| DB11842 | 866 | 40 | None | -1 | 2 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | ||
| P01015 | 866 | 40 | None | -1 | 2 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | ||
| P01019 | 866 | 40 | None | -1 | 2 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | ||
| P11859 | 866 | 40 | None | -1 | 2 | Rat | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | ||
| 127029976 | 276543 | 0 | None | None | None | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787767 | 276543 | 0 | None | None | None | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| 127029976 | 276543 | 0 | None | None | None | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787767 | 276543 | 0 | None | None | None | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| 172198 | 866 | 40 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| 2504 | 866 | 40 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| 5272 | 866 | 40 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| CHEMBL408403 | 866 | 40 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| DB11842 | 866 | 40 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| P01015 | 866 | 40 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| P01019 | 866 | 40 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| P11859 | 866 | 40 | None | 1 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | ||
| 178294851 | 466751 | 0 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 1485 | 38 | 14 | 14 | 5.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | ||
| CHEMBL6160173 | 466751 | 0 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 1485 | 38 | 14 | 14 | 5.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | ||
| 155564502 | 349273 | 0 | None | 2 | 2 | Rat | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 2296 | 33 | 30 | 27 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | ||
| CHEMBL4572408 | 349273 | 0 | None | 2 | 2 | Rat | 7.0 | pEC50 | = | 7 | Functional | ChEMBL | 2296 | 33 | 30 | 27 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | ||
| 11943 | 8428 | 0 | None | 14 | 2 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | nan | ||
| 145925549 | 8428 | 0 | None | 14 | 2 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | nan | ||
| 162679549 | 8428 | 0 | None | 14 | 2 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | nan | ||
| CHEMBL4438122 | 8428 | 0 | None | 14 | 2 | Rat | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | nan | ||
| 155558059 | 348723 | 0 | None | -5 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 790 | 23 | 12 | 11 | -4.6 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C | nan | ||
| CHEMBL4559239 | 348723 | 0 | None | -5 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 790 | 23 | 12 | 11 | -4.6 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C | nan | ||
| 178294851 | 466751 | 0 | None | None | None | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 1485 | 38 | 14 | 14 | 5.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | ||
| CHEMBL6160173 | 466751 | 0 | None | None | None | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 1485 | 38 | 14 | 14 | 5.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | ||
| 155541440 | 347135 | 0 | None | -1 | 2 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | ||
| CHEMBL4518530 | 347135 | 0 | None | -1 | 2 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | ||
| 11316919 | 6249 | 31 | None | -2 | 8 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 451 | 4 | 0 | 4 | 5.3 | Clc1c(cccc1)n1nc2C(=O)N(CCOc2c1c1ccc(cc1)Cl)CC(C)(F)F | 10.6019/CHEMBL5442687 | ||
| 11693 | 6249 | 31 | None | -2 | 8 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 451 | 4 | 0 | 4 | 5.3 | Clc1c(cccc1)n1nc2C(=O)N(CCOc2c1c1ccc(cc1)Cl)CC(C)(F)F | 10.6019/CHEMBL5442687 | ||
| CHEMBL484929 | 6249 | 31 | None | -2 | 8 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 451 | 4 | 0 | 4 | 5.3 | Clc1c(cccc1)n1nc2C(=O)N(CCOc2c1c1ccc(cc1)Cl)CC(C)(F)F | 10.6019/CHEMBL5442687 | ||
| 178312143 | 466237 | 0 | None | None | None | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 1644 | 47 | 15 | 17 | 5.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CCOCCOCCNC(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | ||
| CHEMBL6133895 | 466237 | 0 | None | None | None | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 1644 | 47 | 15 | 17 | 5.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CCOCCOCCNC(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | ||
| 155541295 | 347127 | 0 | None | 4 | 2 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 926 | 25 | 12 | 12 | -2.0 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | ||
| CHEMBL4518318 | 347127 | 0 | None | 4 | 2 | Rat | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 926 | 25 | 12 | 12 | -2.0 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | ||
| 155540639 | 347052 | 0 | None | -6 | 2 | Rat | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| 155552475 | 347052 | 0 | None | -6 | 2 | Rat | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| CHEMBL4516768 | 347052 | 0 | None | -6 | 2 | Rat | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| CHEMBL4543860 | 347052 | 0 | None | -6 | 2 | Rat | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| CHEMBL2028943 | 485018 | 0 | None | -1 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 1018 | 28 | 13 | 13 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O | nan | ||
| 155553930 | 349442 | 0 | None | -1 | 2 | Rat | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 1177 | 26 | 13 | 12 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL4576650 | 349442 | 0 | None | -1 | 2 | Rat | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 1177 | 26 | 13 | 12 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| 155540033 | 347010 | 0 | None | -2 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | ||
| CHEMBL4515768 | 347010 | 0 | None | -2 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | ||
| 127029977 | 276544 | 0 | None | None | None | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787768 | 276544 | 0 | None | None | None | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| 127029977 | 276544 | 0 | None | None | None | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787768 | 276544 | 0 | None | None | None | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | ||
| 127031545 | 276524 | 0 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787701 | 276524 | 0 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| 127031545 | 276524 | 0 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| CHEMBL3787701 | 276524 | 0 | None | None | None | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | ||
| 172198 | 866 | 40 | None | 1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | ||
| 2504 | 866 | 40 | None | 1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | ||
| 5272 | 866 | 40 | None | 1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | ||
| CHEMBL408403 | 866 | 40 | None | 1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | ||
| DB11842 | 866 | 40 | None | 1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | ||
| P01015 | 866 | 40 | None | 1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | ||
| P01019 | 866 | 40 | None | 1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | ||
| P11859 | 866 | 40 | None | 1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | ||
| 155541440 | 347135 | 0 | None | 1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | ||
| CHEMBL4518530 | 347135 | 0 | None | 1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | ||
| 10533900 | 349944 | 16 | None | 10 | 2 | Rat | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | ||
| CHEMBL4588454 | 349944 | 16 | None | 10 | 2 | Rat | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | ||
| 155556507 | 348534 | 0 | None | 2 | 2 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 910 | 26 | 12 | 11 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL4554466 | 348534 | 0 | None | 2 | 2 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 910 | 26 | 12 | 11 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| 155563538 | 349310 | 0 | None | -1 | 2 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 925 | 26 | 13 | 12 | -2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O | nan | ||
| CHEMBL4573250 | 349310 | 0 | None | -1 | 2 | Rat | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 925 | 26 | 13 | 12 | -2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O | nan | ||
| 178298467 | 466518 | 0 | None | None | None | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 1414 | 32 | 13 | 16 | 2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)NC(=O)c1ccccc1-c1c2ccc(=[N+](C)C)cc-2oc2cc(N(C)C)ccc12)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | ||
| CHEMBL6147645 | 466518 | 0 | None | None | None | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 1414 | 32 | 13 | 16 | 2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)NC(=O)c1ccccc1-c1c2ccc(=[N+](C)C)cc-2oc2cc(N(C)C)ccc12)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | ||
| 155559104 | 348841 | 0 | None | 2 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 940 | 26 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | ||
| CHEMBL4562270 | 348841 | 0 | None | 2 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 940 | 26 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | ||
| 155554865 | 348406 | 0 | None | 2 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 2269 | 27 | 21 | 24 | 3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | ||
| CHEMBL4551317 | 348406 | 0 | None | 2 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 2269 | 27 | 21 | 24 | 3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | ||
| 155540328 | 347021 | 0 | None | -3 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | ||
| CHEMBL4516066 | 347021 | 0 | None | -3 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | ||
| 155553479 | 348239 | 0 | None | 3 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 949 | 26 | 14 | 13 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | ||
| CHEMBL4547423 | 348239 | 0 | None | 3 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 949 | 26 | 14 | 13 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | ||
| 155558003 | 348733 | 0 | None | 1 | 2 | Rat | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 1015 | 28 | 13 | 16 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL4559421 | 348733 | 0 | None | 1 | 2 | Rat | 5.6 | pEC50 | = | 5.6 | Functional | ChEMBL | 1015 | 28 | 13 | 16 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| 155547428 | 347706 | 0 | None | -22 | 2 | Rat | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | 959 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL4533618 | 347706 | 0 | None | -22 | 2 | Rat | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | 959 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| 155566196 | 349730 | 0 | None | -5 | 2 | Rat | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | 954 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL4583284 | 349730 | 0 | None | -5 | 2 | Rat | 4.6 | pEC50 | = | 4.6 | Functional | ChEMBL | 954 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| 155558428 | 348767 | 0 | None | 1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 897 | 26 | 15 | 12 | -3.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | ||
| CHEMBL4560224 | 348767 | 0 | None | 1 | 2 | Rat | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 897 | 26 | 15 | 12 | -3.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | ||
| 155552190 | 348136 | 0 | None | 4 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 869 | 26 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | ||
| CHEMBL4544228 | 348136 | 0 | None | 4 | 2 | Rat | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 869 | 26 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | ||
| CHEMBL77838 | 489382 | 3 | None | -1 | 2 | Rat | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 954 | 27 | 12 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O | nan | ||
| 155540639 | 347052 | 0 | None | 6 | 2 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| 155552475 | 347052 | 0 | None | 6 | 2 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| CHEMBL4516768 | 347052 | 0 | None | 6 | 2 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| CHEMBL4543860 | 347052 | 0 | None | 6 | 2 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| 155542907 | 347287 | 0 | None | 3 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 904 | 24 | 13 | 12 | -1.5 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C | nan | ||
| CHEMBL4522038 | 347287 | 0 | None | 3 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 904 | 24 | 13 | 12 | -1.5 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C | nan | ||
| CHEMBL2028943 | 485018 | 0 | None | 1 | 2 | Rat | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 1018 | 28 | 13 | 13 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O | nan | ||
| 155540639 | 347052 | 0 | None | -6 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| 155552475 | 347052 | 0 | None | -6 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| CHEMBL4516768 | 347052 | 0 | None | -6 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| CHEMBL4543860 | 347052 | 0 | None | -6 | 2 | Rat | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | ||
| 155556530 | 348559 | 0 | None | 2 | 2 | Rat | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 911 | 25 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C | nan | ||
| CHEMBL4555119 | 348559 | 0 | None | 2 | 2 | Rat | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 911 | 25 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C | nan | ||
| 155561376 | 349666 | 0 | None | 12 | 2 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 917 | 28 | 12 | 11 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O | nan | ||
| CHEMBL4581718 | 349666 | 0 | None | 12 | 2 | Rat | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 917 | 28 | 12 | 11 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O | nan | ||
| 155541125 | 347083 | 0 | None | 6 | 2 | Rat | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | nan | ||
| CHEMBL4517561 | 347083 | 0 | None | 6 | 2 | Rat | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | nan | ||
| 178298467 | 466518 | 0 | None | None | None | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 1414 | 32 | 13 | 16 | 2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)NC(=O)c1ccccc1-c1c2ccc(=[N+](C)C)cc-2oc2cc(N(C)C)ccc12)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | ||
| CHEMBL6147645 | 466518 | 0 | None | None | None | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 1414 | 32 | 13 | 16 | 2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)NC(=O)c1ccccc1-c1c2ccc(=[N+](C)C)cc-2oc2cc(N(C)C)ccc12)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | ||
| 178312143 | 466237 | 0 | None | None | None | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 1644 | 47 | 15 | 17 | 5.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CCOCCOCCNC(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | ||
| CHEMBL6133895 | 466237 | 0 | None | None | None | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 1644 | 47 | 15 | 17 | 5.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CCOCCOCCNC(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | ||
| 24892627 | 118474 | 4 | None | -5 | 2 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 548 | 8 | 0 | 6 | 5.0 | Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1 | nan | ||
| CHEMBL1621632 | 118474 | 4 | None | -5 | 2 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 548 | 8 | 0 | 6 | 5.0 | Cc1ccc2nc(N(CCCN(C)C)C(=O)c3ccc(S(=O)(=O)N4CCc5ccccc5C4)cc3)sc2c1 | nan | ||
| 155558059 | 348723 | 0 | None | 5 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 790 | 23 | 12 | 11 | -4.6 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C | nan | ||
| CHEMBL4559239 | 348723 | 0 | None | 5 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 790 | 23 | 12 | 11 | -4.6 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C | nan | ||
| 3542 | 484387 | 24 | None | 1 | 2 | Rat | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | ||
| CHEMBL938 | 484387 | 24 | None | 1 | 2 | Rat | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | ||
| CHEMBL312754 | 484256 | 17 | None | 1 | 2 | Rat | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 926 | 26 | 12 | 12 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | ||
| 154573825 | 349963 | 16 | None | 8 | 2 | Rat | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | ||
| CHEMBL4588946 | 349963 | 16 | None | 8 | 2 | Rat | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | ||
| 155560463 | 349067 | 0 | None | -1 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 1052 | 28 | 14 | 13 | -0.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | nan | ||
| CHEMBL4567667 | 349067 | 0 | None | -1 | 2 | Rat | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 1052 | 28 | 14 | 13 | -0.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | nan | ||
| 155553003 | 348142 | 0 | None | 1 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | ||
| CHEMBL4544308 | 348142 | 0 | None | 1 | 2 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | ||
| 10533900 | 349944 | 16 | None | -10 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | ||
| CHEMBL4588454 | 349944 | 16 | None | -10 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | ||
| CHEMBL2392353 | 485980 | 4 | None | 1 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 970 | 27 | 14 | 13 | -2.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | ||
| 155553098 | 348173 | 0 | None | 22 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 969 | 28 | 16 | 13 | -3.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | ||
| CHEMBL4545153 | 348173 | 0 | None | 22 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 969 | 28 | 16 | 13 | -3.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | ||
| 1588251 | 122058 | 6 | None | None | None | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 436 | 4 | 0 | 5 | 5.8 | CCN1C(c2ccccc2)=C(c2ccccc2)S/C1=C\C=C1/SC(=S)N(C)C1=O | nan | ||
| CHEMBL1704271 | 122058 | 6 | None | None | None | Human | 5.1 | pEC50 | = | 5.1 | Functional | ChEMBL | 436 | 4 | 0 | 5 | 5.8 | CCN1C(c2ccccc2)=C(c2ccccc2)S/C1=C\C=C1/SC(=S)N(C)C1=O | nan | ||
| 155540328 | 347021 | 0 | None | 3 | 2 | Rat | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | ||
| CHEMBL4516066 | 347021 | 0 | None | 3 | 2 | Rat | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | ||
| 155540033 | 347010 | 0 | None | 2 | 2 | Rat | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | ||
| CHEMBL4515768 | 347010 | 0 | None | 2 | 2 | Rat | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | ||
| 155539838 | 347015 | 0 | None | 2 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| 155543091 | 347015 | 0 | None | 2 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| 155553311 | 347015 | 0 | None | 2 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| 155568318 | 347015 | 0 | None | 2 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL4515848 | 347015 | 0 | None | 2 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL4522246 | 347015 | 0 | None | 2 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL4546162 | 347015 | 0 | None | 2 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL4591448 | 347015 | 0 | None | 2 | 2 | Rat | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | ||
| CHEMBL312754 | 484256 | 17 | None | -1 | 2 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 926 | 26 | 12 | 12 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | 10.1021/acs.jmedchem.4c01693 | ||
| 178312143 | 466237 | 0 | None | None | None | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 1644 | 47 | 15 | 17 | 5.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CCOCCOCCNC(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | ||
| CHEMBL6133895 | 466237 | 0 | None | None | None | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 1644 | 47 | 15 | 17 | 5.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CCOCCOCCNC(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | ||
| 178298467 | 466518 | 0 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 1414 | 32 | 13 | 16 | 2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)NC(=O)c1ccccc1-c1c2ccc(=[N+](C)C)cc-2oc2cc(N(C)C)ccc12)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | ||
| CHEMBL6147645 | 466518 | 0 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 1414 | 32 | 13 | 16 | 2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)NC(=O)c1ccccc1-c1c2ccc(=[N+](C)C)cc-2oc2cc(N(C)C)ccc12)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | ||
| CHEMBL312754 | 484256 | 17 | None | -1 | 2 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 926 | 26 | 12 | 12 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | 10.1021/acs.jmedchem.4c01693 | ||
| CHEMBL2370909 | 485633 | 0 | None | 7 | 2 | Rat | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 984 | 29 | 13 | 13 | -2.3 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O | nan | ||
| 178294851 | 466751 | 0 | None | None | None | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 1485 | 38 | 14 | 14 | 5.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | ||
| CHEMBL6160173 | 466751 | 0 | None | None | None | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 1485 | 38 | 14 | 14 | 5.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | ||
| 155558784 | 348813 | 0 | None | -2 | 2 | Rat | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 756 | 9 | 7 | 8 | 1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | ||
| CHEMBL4561366 | 348813 | 0 | None | -2 | 2 | Rat | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 756 | 9 | 7 | 8 | 1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | ||
| 154573825 | 349963 | 16 | None | -8 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | ||
| CHEMBL4588946 | 349963 | 16 | None | -8 | 2 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | ||
| 155553003 | 348142 | 0 | None | -1 | 2 | Rat | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | ||
| CHEMBL4544308 | 348142 | 0 | None | -1 | 2 | Rat | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | ||
| 3025727 | 367402 | 5 | None | 10000 | 2 | Rabbit | 10.3 | pIC50 | = | 10.3 | Functional | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL48242 | 367402 | 5 | None | 10000 | 2 | Rabbit | 10.3 | pIC50 | = | 10.3 | Functional | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 14971704 | 221870 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL329616 | 221870 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 133031 | 201002 | 20 | None | 1 | 3 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm1013693 | ||
| CHEMBL293511 | 201002 | 20 | None | 1 | 3 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm1013693 | ||
| 9892554 | 200364 | 5 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 510 | 9 | 1 | 8 | 3.5 | CCCCc1nc2ccn(CC(=O)N(C)C)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL288246 | 200364 | 5 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 510 | 9 | 1 | 8 | 3.5 | CCCCc1nc2ccn(CC(=O)N(C)C)c(=O)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 14971715 | 332949 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 492 | 10 | 2 | 6 | 5.4 | CCCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL433646 | 332949 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 492 | 10 | 2 | 6 | 5.4 | CCCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971716 | 38432 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 506 | 11 | 2 | 6 | 5.6 | CCCCc1nn(CCc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120199 | 38432 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 506 | 11 | 2 | 6 | 5.6 | CCCCc1nn(CCc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971706 | 474119 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL92654 | 474119 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 183134 | 7963 | 16 | None | -4 | 6 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm1013693 | ||
| 3939 | 7963 | 16 | None | -4 | 6 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm1013693 | ||
| CHEMBL7550 | 7963 | 16 | None | -4 | 6 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm1013693 | ||
| 14971698 | 474196 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2ccccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL93226 | 474196 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2ccccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 9827346 | 199926 | 6 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 501 | 7 | 2 | 8 | 3.4 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL284918 | 199926 | 6 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 501 | 7 | 2 | 8 | 3.4 | CCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/c(=N/C(=O)C2=C(C(=O)O)CCC2)s1 | 10.1016/j.bmc.2010.10.043 | ||
| 4906 | 143124 | 59 | None | 15 | 2 | Rabbit | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 9870652 | 143124 | 59 | None | 15 | 2 | Rabbit | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951143 | 143124 | 59 | None | 15 | 2 | Rabbit | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| DB09279 | 143124 | 59 | None | 15 | 2 | Rabbit | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14971720 | 233815 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.0 | CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL334145 | 233815 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.0 | CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 14971720 | 233815 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.0 | CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL334145 | 233815 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.0 | CCCc1nn(Cc2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971705 | 473696 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 492 | 9 | 2 | 6 | 5.7 | CCCCc1nn(-c2ccccc2C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL90011 | 473696 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 492 | 9 | 2 | 6 | 5.7 | CCCCc1nn(-c2ccccc2C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10325927 | 473821 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 580 | 9 | 2 | 6 | 7.3 | CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL90774 | 473821 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 580 | 9 | 2 | 6 | 7.3 | CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971714 | 199410 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 484 | 9 | 2 | 6 | 4.9 | CCCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL281386 | 199410 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 484 | 9 | 2 | 6 | 4.9 | CCCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 183134 | 7963 | 16 | None | -2 | 6 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm00078a013 | ||
| 183134 | 7963 | 16 | None | -2 | 6 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm00078a014 | ||
| 3939 | 7963 | 16 | None | -2 | 6 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm00078a013 | ||
| 3939 | 7963 | 16 | None | -2 | 6 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm00078a014 | ||
| CHEMBL7550 | 7963 | 16 | None | -2 | 6 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm00078a013 | ||
| CHEMBL7550 | 7963 | 16 | None | -2 | 6 | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm00078a014 | ||
| 14971639 | 233154 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.1 | CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL332897 | 233154 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.1 | CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 14971639 | 233154 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.1 | CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL332897 | 233154 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.1 | CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971702 | 474094 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL92472 | 474094 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 4673492 | 8951 | 9 | None | 6 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.6019/CHEMBL5442687 | ||
| 8324 | 8951 | 9 | None | 6 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.6019/CHEMBL5442687 | ||
| CHEMBL159096 | 8951 | 9 | None | 6 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.6019/CHEMBL5442687 | ||
| 14971710 | 474292 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 554 | 10 | 2 | 6 | 7.0 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL93886 | 474292 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 554 | 10 | 2 | 6 | 7.0 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971717 | 38488 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 532 | 8 | 2 | 6 | 6.0 | CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120457 | 38488 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 532 | 8 | 2 | 6 | 6.0 | CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10369813 | 235848 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 532 | 8 | 2 | 6 | 6.3 | CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL338740 | 235848 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 532 | 8 | 2 | 6 | 6.3 | CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 142534045 | 331296 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 543 | 9 | 1 | 7 | 4.9 | CCCCc1nc(C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4278280 | 331296 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 543 | 9 | 1 | 7 | 4.9 | CCCCc1nc(C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 14956763 | 328375 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 526 | 10 | 1 | 10 | 4.2 | CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL419483 | 328375 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 526 | 10 | 1 | 10 | 4.2 | CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14971701 | 474312 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL94002 | 474312 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971708 | 233599 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 508 | 10 | 2 | 7 | 5.4 | CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL333800 | 233599 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 508 | 10 | 2 | 7 | 5.4 | CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10393717 | 235028 | 0 | None | 524 | 2 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 595 | 11 | 1 | 7 | 6.1 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 | 10.1021/jm00078a014 | ||
| CHEMBL335722 | 235028 | 0 | None | 524 | 2 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 595 | 11 | 1 | 7 | 6.1 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 | 10.1021/jm00078a014 | ||
| 9914666 | 235569 | 0 | None | 3388 | 2 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 520 | 5 | 1 | 6 | 6.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| CHEMBL337086 | 235569 | 0 | None | 3388 | 2 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 520 | 5 | 1 | 6 | 6.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| 14956739 | 473279 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87074 | 473279 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 192567 | 235555 | 4 | None | 223 | 2 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 581 | 10 | 1 | 7 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL337007 | 235555 | 4 | None | 223 | 2 | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 581 | 10 | 1 | 7 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)NS(=O)(=O)c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| 10140613 | 215780 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 479 | 10 | 1 | 7 | 4.5 | CCCCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313371 | 215780 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 479 | 10 | 1 | 7 | 4.5 | CCCCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956772 | 215632 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 510 | 10 | 1 | 9 | 4.6 | CCCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL312913 | 215632 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 510 | 10 | 1 | 9 | 4.6 | CCCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 192345 | 59916 | 3 | None | 12022 | 2 | Rabbit | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 496 | 6 | 1 | 7 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | ||
| CHEMBL135775 | 59916 | 3 | None | 12022 | 2 | Rabbit | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 496 | 6 | 1 | 7 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | ||
| 10326140 | 235554 | 0 | None | 2884 | 2 | Rabbit | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 593 | 11 | 1 | 7 | 5.9 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 | 10.1021/jm00078a014 | ||
| CHEMBL337006 | 235554 | 0 | None | 2884 | 2 | Rabbit | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 593 | 11 | 1 | 7 | 5.9 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)NS(=O)(=O)c1ccccc1)c1ccccc1 | 10.1021/jm00078a014 | ||
| 9807766 | 143116 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 555 | 9 | 1 | 8 | 4.0 | CCCCc1nc(C)c(CC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951136 | 143116 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 555 | 9 | 1 | 8 | 4.0 | CCCCc1nc(C)c(CC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 60770 | 334073 | 18 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 506 | 8 | 2 | 6 | 5.1 | CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL443269 | 334073 | 18 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 506 | 8 | 2 | 6 | 5.1 | CCCc1nc(C(F)(F)C(F)(F)F)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 142534141 | 331970 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 557 | 9 | 1 | 7 | 5.3 | CCCCc1nc(C)c(CC(=S)N2CCCC2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4291216 | 331970 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 557 | 9 | 1 | 7 | 5.3 | CCCCc1nc(C)c(CC(=S)N2CCCC2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 14956757 | 139872 | 0 | None | 831 | 2 | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL19018 | 139872 | 0 | None | 831 | 2 | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14971700 | 474348 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL94221 | 474348 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 9871638 | 143125 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 529 | 11 | 1 | 7 | 5.0 | CCCCc1nc(C)c(CC(=S)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951144 | 143125 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 529 | 11 | 1 | 7 | 5.0 | CCCCc1nc(C)c(CC(=S)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 44320012 | 332677 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 493 | 9 | 1 | 7 | 5.4 | CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL431411 | 332677 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 493 | 9 | 1 | 7 | 5.4 | CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 155542482 | 347240 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 487 | 9 | 1 | 6 | 5.5 | CCCCC1=NC(C)=C(CC(=S)N(C)C)CN1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2018.12.043 | ||
| CHEMBL4520827 | 347240 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 487 | 9 | 1 | 6 | 5.5 | CCCCC1=NC(C)=C(CC(=S)N(C)C)CN1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2018.12.043 | ||
| 44213341 | 143109 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 511 | 9 | 1 | 7 | 4.0 | CCCCc1nc(C)c(CC(=O)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951129 | 143109 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 511 | 9 | 1 | 7 | 4.0 | CCCCc1nc(C)c(CC(=O)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 137532858 | 331889 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 517 | 9 | 1 | 7 | 4.4 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4289788 | 331889 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 517 | 9 | 1 | 7 | 4.4 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 14971719 | 233790 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 470 | 8 | 2 | 6 | 4.5 | CCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL333978 | 233790 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 470 | 8 | 2 | 6 | 4.5 | CCCc1nn(CC(F)(F)F)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971711 | 40440 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 479 | 9 | 2 | 7 | 4.7 | CCCCc1nn(-c2ccccn2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL123767 | 40440 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 479 | 9 | 2 | 7 | 4.7 | CCCCc1nn(-c2ccccn2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971707 | 474236 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 523 | 10 | 2 | 8 | 5.3 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL93547 | 474236 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 523 | 10 | 2 | 8 | 5.3 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 44213349 | 143115 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 527 | 9 | 1 | 8 | 3.2 | CCCCc1nc(C)c(CC(=O)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951135 | 143115 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 527 | 9 | 1 | 8 | 3.2 | CCCCc1nc(C)c(CC(=O)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 20081627 | 182962 | 0 | None | 1 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 502 | 6 | 2 | 7 | 4.7 | CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL24224 | 182962 | 0 | None | 1 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 502 | 6 | 2 | 7 | 4.7 | CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/j.bmc.2010.10.043 | ||
| 145981239 | 331424 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 571 | 9 | 1 | 7 | 5.7 | CCCCc1nc(C)c(CC(=S)N2[C@H](C)CC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4280574 | 331424 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 571 | 9 | 1 | 7 | 5.7 | CCCCc1nc(C)c(CC(=S)N2[C@H](C)CC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 131654 | 473370 | 11 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87778 | 473370 | 11 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956781 | 470957 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 443 | 8 | 1 | 7 | 4.4 | CCCCc1nn(C2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86314 | 470957 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 443 | 8 | 1 | 7 | 4.4 | CCCCc1nn(C2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 9845644 | 473400 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 431 | 9 | 1 | 7 | 4.3 | CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87964 | 473400 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 431 | 9 | 1 | 7 | 4.3 | CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 1610 | 7967 | 67 | None | -2 | 8 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0603163 | ||
| 3941 | 7967 | 67 | None | -2 | 8 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0603163 | ||
| 3961 | 7967 | 67 | None | -2 | 8 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0603163 | ||
| CHEMBL191 | 7967 | 67 | None | -2 | 8 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0603163 | ||
| 10095589 | 234457 | 0 | None | 851 | 2 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 456 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
| CHEMBL335289 | 234457 | 0 | None | 851 | 2 | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 456 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
| 19939399 | 215844 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 609 | 11 | 2 | 10 | 5.2 | CCCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313696 | 215844 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 609 | 11 | 2 | 10 | 5.2 | CCCCc1nn(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10222835 | 470930 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 403 | 8 | 1 | 7 | 3.3 | CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86084 | 470930 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 403 | 8 | 1 | 7 | 3.3 | CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 142533975 | 331851 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 571 | 10 | 1 | 7 | 5.7 | CCCCc1nc(C(C)C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4288964 | 331851 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 571 | 10 | 1 | 7 | 5.7 | CCCCc1nc(C(C)C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 44348352 | 40415 | 0 | None | 1 | 2 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 459 | 8 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL123713 | 40415 | 0 | None | 1 | 2 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 459 | 8 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC | 10.1016/j.bmc.2010.10.043 | ||
| 14971675 | 473901 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 540 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL91287 | 473901 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 540 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccc(Cl)cc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10048220 | 59871 | 0 | None | 109 | 2 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 428 | 7 | 2 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
| CHEMBL135704 | 59871 | 0 | None | 109 | 2 | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 428 | 7 | 2 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
| 14956760 | 330377 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 466 | 8 | 2 | 8 | 3.9 | CCCCc1nn(-c2ccccc2N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL424053 | 330377 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 466 | 8 | 2 | 8 | 3.9 | CCCCc1nn(-c2ccccc2N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956777 | 473303 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 415 | 8 | 1 | 7 | 3.6 | CCCCc1nn(C2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87276 | 473303 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 415 | 8 | 1 | 7 | 3.6 | CCCCc1nn(C2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 164611301 | 368322 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 416 | 7 | 1 | 5 | 3.9 | CCCC[C@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@H]2CCCN21 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4854916 | 368322 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 416 | 7 | 1 | 5 | 3.9 | CCCC[C@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@H]2CCCN21 | 10.1021/acsmedchemlett.1c00240 | ||
| 1240113 | 63124 | 6 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 265 | 3 | 0 | 2 | 4.8 | Cc1cccc(CSc2cccc3cccnc23)c1 | nan | ||
| CHEMBL1384550 | 63124 | 6 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 265 | 3 | 0 | 2 | 4.8 | Cc1cccc(CSc2cccc3cccnc23)c1 | nan | ||
| 164622816 | 369157 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 416 | 7 | 1 | 5 | 3.9 | CCCC[C@@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@@H]2CCCN21 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4868159 | 369157 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 416 | 7 | 1 | 5 | 3.9 | CCCC[C@@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@@H]2CCCN21 | 10.1021/acsmedchemlett.1c00240 | ||
| 5411796 | 144151 | 7 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 335 | 4 | 1 | 3 | 3.9 | O=C(N/N=C(\c1ccccc1)c1ccccn1)c1ccccc1Cl | nan | ||
| CHEMBL1972216 | 144151 | 7 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 335 | 4 | 1 | 3 | 3.9 | O=C(N/N=C(\c1ccccc1)c1ccccn1)c1ccccc1Cl | nan | ||
| 5740287 | 83629 | 6 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 394 | 6 | 0 | 7 | 4.3 | COc1cc(/C=C/c2ccc3cccc(OC)c3n2)c(OC(C)=O)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1480264 | 83629 | 6 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 394 | 6 | 0 | 7 | 4.3 | COc1cc(/C=C/c2ccc3cccc(OC)c3n2)c(OC(C)=O)c([N+](=O)[O-])c1 | nan | ||
| 5738419 | 101706 | 13 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 253 | 2 | 1 | 3 | 4.2 | Oc1cccc2ccc(/C=C/c3cccs3)nc12 | nan | ||
| CHEMBL1555793 | 101706 | 13 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 253 | 2 | 1 | 3 | 4.2 | Oc1cccc2ccc(/C=C/c3cccs3)nc12 | nan | ||
| 659124 | 81888 | 8 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 406 | 7 | 1 | 7 | 4.4 | CCCCn1c(NC(=O)c2ccco2)c(C(=O)OCC)c2nc3ccccc3nc21 | nan | ||
| CHEMBL1463829 | 81888 | 8 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 406 | 7 | 1 | 7 | 4.4 | CCCCn1c(NC(=O)c2ccco2)c(C(=O)OCC)c2nc3ccccc3nc21 | nan | ||
| 1183382 | 47330 | 13 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 367 | 5 | 0 | 7 | 3.3 | COc1cc(/C=C/[N+](=O)[O-])ccc1OC(=O)c1cc2ccccc2oc1=O | nan | ||
| CHEMBL1333737 | 47330 | 13 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 367 | 5 | 0 | 7 | 3.3 | COc1cc(/C=C/[N+](=O)[O-])ccc1OC(=O)c1cc2ccccc2oc1=O | nan | ||
| 1334532 | 80391 | 6 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 365 | 2 | 3 | 4 | 3.0 | Cc1cc(O)ccc1NC(=S)NC(=O)c1cncc(Br)c1 | nan | ||
| CHEMBL1451169 | 80391 | 6 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 365 | 2 | 3 | 4 | 3.0 | Cc1cc(O)ccc1NC(=S)NC(=O)c1cncc(Br)c1 | nan | ||
| 10257526 | 221857 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2cc(Cl)ccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL329541 | 221857 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2cc(Cl)ccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 5952109 | 144269 | 8 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 389 | 4 | 1 | 5 | 5.6 | CC(=O)/C(=N\Nc1ccc(Cl)cc1Cl)Sc1cccc2cccnc12 | nan | ||
| CHEMBL1976317 | 144269 | 8 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 389 | 4 | 1 | 5 | 5.6 | CC(=O)/C(=N\Nc1ccc(Cl)cc1Cl)Sc1cccc2cccnc12 | nan | ||
| 2236648 | 62364 | 8 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 355 | 2 | 3 | 3 | 3.0 | CC(C)(C)C(=O)NC(=S)NNC(=O)c1ccc(-c2ccccc2)cc1 | nan | ||
| CHEMBL1377849 | 62364 | 8 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 355 | 2 | 3 | 3 | 3.0 | CC(C)(C)C(=O)NC(=S)NNC(=O)c1ccc(-c2ccccc2)cc1 | nan | ||
| 6154033 | 218088 | 6 | None | 1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 319 | 4 | 1 | 3 | 3.4 | O=C(N/N=C(\c1ccccc1)c1cccnc1)c1cccc(F)c1 | nan | ||
| CHEMBL3199403 | 218088 | 6 | None | 1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 319 | 4 | 1 | 3 | 3.4 | O=C(N/N=C(\c1ccccc1)c1cccnc1)c1cccc(F)c1 | nan | ||
| 4116022 | 104230 | 4 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 368 | 10 | 1 | 9 | 3.4 | CCCSc1cc(NCCOC(=O)CCC)c([N+](=O)[O-])c2nonc12 | nan | ||
| CHEMBL1578324 | 104230 | 4 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 368 | 10 | 1 | 9 | 3.4 | CCCSc1cc(NCCOC(=O)CCC)c([N+](=O)[O-])c2nonc12 | nan | ||
| 19939367 | 215635 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL312921 | 215635 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956804 | 215683 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 493 | 11 | 1 | 7 | 4.9 | CCCCc1nn(CCCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313222 | 215683 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 493 | 11 | 1 | 7 | 4.9 | CCCCc1nn(CCCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956792 | 216427 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314447 | 216427 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956754 | 313285 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 541 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL407827 | 313285 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 541 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956787 | 473319 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 461 | 9 | 1 | 9 | 3.0 | CCCCc1nn(C(C)C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87363 | 473319 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 461 | 9 | 1 | 9 | 3.0 | CCCCc1nn(C(C)C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 44373246 | 332975 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 435 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 | 10.1021/jm9504722 | ||
| CHEMBL433895 | 332975 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 435 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 | 10.1021/jm9504722 | ||
| 14956796 | 470608 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2cccc(C(=O)OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL83182 | 470608 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2cccc(C(=O)OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10094520 | 58452 | 0 | None | 11 | 2 | Rabbit | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C | 10.1021/jm00078a013 | ||
| CHEMBL134433 | 58452 | 0 | None | 11 | 2 | Rabbit | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1C | 10.1021/jm00078a013 | ||
| 3504072 | 67246 | 9 | None | 1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 299 | 2 | 2 | 3 | 2.1 | O=C(NNC(=O)C12CC3CC(CC(C3)C1)C2)c1ccccn1 | nan | ||
| CHEMBL1421427 | 67246 | 9 | None | 1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 299 | 2 | 2 | 3 | 2.1 | O=C(NNC(=O)C12CC3CC(CC(C3)C1)C2)c1ccccn1 | nan | ||
| 869765 | 82038 | 6 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 322 | 5 | 2 | 6 | 3.1 | COc1ccc(-c2cc(-c3ccccc3)nc(NN)n2)cc1OC | nan | ||
| CHEMBL1464917 | 82038 | 6 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 322 | 5 | 2 | 6 | 3.1 | COc1ccc(-c2cc(-c3ccccc3)nc(NN)n2)cc1OC | nan | ||
| 16446215 | 100872 | 8 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 467 | 7 | 1 | 6 | 4.3 | Cc1ccc(CS(=O)(=O)c2ncc(Cl)c(C(=O)Nc3ccc(OC(F)F)cc3)n2)cc1 | nan | ||
| CHEMBL1546607 | 100872 | 8 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 467 | 7 | 1 | 6 | 4.3 | Cc1ccc(CS(=O)(=O)c2ncc(Cl)c(C(=O)Nc3ccc(OC(F)F)cc3)n2)cc1 | nan | ||
| 5295671 | 78988 | 7 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 314 | 2 | 0 | 6 | 2.1 | CC(=O)C1=C(c2ccccc2)N(C(C)=O)n2c(C)nnc2S1 | nan | ||
| CHEMBL1438779 | 78988 | 7 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 314 | 2 | 0 | 6 | 2.1 | CC(=O)C1=C(c2ccccc2)N(C(C)=O)n2c(C)nnc2S1 | nan | ||
| 1653161 | 83758 | 10 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 319 | 3 | 3 | 5 | 1.2 | COc1ccccc1C(=O)NNC(=S)NC(=O)c1ccco1 | nan | ||
| CHEMBL1481281 | 83758 | 10 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 319 | 3 | 3 | 5 | 1.2 | COc1ccccc1C(=O)NNC(=S)NC(=O)c1ccco1 | nan | ||
| 14956759 | 470888 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 495 | 9 | 2 | 8 | 4.0 | CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85704 | 470888 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 495 | 9 | 2 | 8 | 4.0 | CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 5335659 | 218071 | 8 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 257 | 3 | 1 | 3 | 2.4 | C/C(=N\NC(=O)c1ccccc1F)c1ccccn1 | nan | ||
| CHEMBL3199216 | 218071 | 8 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 257 | 3 | 1 | 3 | 2.4 | C/C(=N\NC(=O)c1ccccc1F)c1ccccn1 | nan | ||
| 16446684 | 86411 | 7 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 405 | 5 | 1 | 5 | 3.5 | O=C(Nc1ccc(F)cc1)c1nc(S(=O)(=O)Cc2ccccc2)ncc1Cl | nan | ||
| CHEMBL1504077 | 86411 | 7 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 405 | 5 | 1 | 5 | 3.5 | O=C(Nc1ccc(F)cc1)c1nc(S(=O)(=O)Cc2ccccc2)ncc1Cl | nan | ||
| 2426231 | 81576 | 3 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 394 | 3 | 3 | 3 | 5.3 | Cc1c(Cl)cccc1N=C(S)NNc1ncc(C(F)(F)F)cc1Cl | nan | ||
| CHEMBL1461119 | 81576 | 3 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 394 | 3 | 3 | 3 | 5.3 | Cc1c(Cl)cccc1N=C(S)NNc1ncc(C(F)(F)F)cc1Cl | nan | ||
| 53319274 | 120395 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 559 | 9 | 1 | 7 | 4.2 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL1668000 | 120395 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 559 | 9 | 1 | 7 | 4.2 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | ||
| 10027714 | 234387 | 0 | None | 398 | 2 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 470 | 9 | 1 | 5 | 6.0 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| CHEMBL335066 | 234387 | 0 | None | 398 | 2 | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 470 | 9 | 1 | 5 | 6.0 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| 14956793 | 473284 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87129 | 473284 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956791 | 473314 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 459 | 8 | 2 | 8 | 3.4 | CCCCc1nn(C2CCCC2O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87341 | 473314 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 459 | 8 | 2 | 8 | 3.4 | CCCCc1nn(C2CCCC2O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956798 | 473376 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.0 | CCCCc1nn(C(C(=O)OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87798 | 473376 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.0 | CCCCc1nn(C(C(=O)OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14951059 | 473396 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 493 | 10 | 1 | 8 | 4.2 | CCCCc1nn(CC(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87942 | 473396 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 493 | 10 | 1 | 8 | 4.2 | CCCCc1nn(CC(=O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 11744670 | 234237 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 453 | 5 | 0 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2C#N)c1 | 10.1021/jm00078a013 | ||
| CHEMBL334775 | 234237 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 453 | 5 | 0 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2c(Cl)cccc2C#N)c1 | 10.1021/jm00078a013 | ||
| 14956742 | 473302 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2cccc(Cl)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87275 | 473302 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2cccc(Cl)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 5187118 | 105094 | 5 | None | -5 | 3 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 338 | 3 | 1 | 3 | 4.8 | Oc1c(C(c2ccccc2Cl)N2CCCC2)ccc2cccnc12 | nan | ||
| CHEMBL1585527 | 105094 | 5 | None | -5 | 3 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 338 | 3 | 1 | 3 | 4.8 | Oc1c(C(c2ccccc2Cl)N2CCCC2)ccc2cccnc12 | nan | ||
| 2313746 | 105351 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 333 | 4 | 4 | 7 | 0.6 | O=C1OCC(CO)(CO)N=C1NNc1cc(Cl)ccc1Cl | nan | ||
| CHEMBL1587672 | 105351 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 333 | 4 | 4 | 7 | 0.6 | O=C1OCC(CO)(CO)N=C1NNc1cc(Cl)ccc1Cl | nan | ||
| 6917582 | 98952 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 378 | 3 | 1 | 5 | 3.1 | COc1ccc2c(c1)C(=O)[C@H](O)[C@@H](c1ccc(OC)c(Br)c1)O2 | nan | ||
| 9548123 | 98952 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 378 | 3 | 1 | 5 | 3.1 | COc1ccc2c(c1)C(=O)[C@H](O)[C@@H](c1ccc(OC)c(Br)c1)O2 | nan | ||
| CHEMBL1529805 | 98952 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 378 | 3 | 1 | 5 | 3.1 | COc1ccc2c(c1)C(=O)[C@H](O)[C@@H](c1ccc(OC)c(Br)c1)O2 | nan | ||
| CHEMBL1548173 | 98952 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 378 | 3 | 1 | 5 | 3.1 | COc1ccc2c(c1)C(=O)[C@H](O)[C@@H](c1ccc(OC)c(Br)c1)O2 | nan | ||
| 665535 | 98278 | 4 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 425 | 7 | 1 | 9 | 1.8 | COC(=O)CS(=O)(=O)c1nnc([C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)o1 | nan | ||
| CHEMBL1523699 | 98278 | 4 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 425 | 7 | 1 | 9 | 1.8 | COC(=O)CS(=O)(=O)c1nnc([C@H](Cc2ccccc2)NC(=O)OC(C)(C)C)o1 | nan | ||
| 2812568 | 80666 | 2 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 286 | 3 | 2 | 3 | 3.8 | O=C(NNc1ccc(Cl)cc1)c1sccc1Cl | nan | ||
| CHEMBL1453309 | 80666 | 2 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 286 | 3 | 2 | 3 | 3.8 | O=C(NNc1ccc(Cl)cc1)c1sccc1Cl | nan | ||
| 921731 | 105406 | 6 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 321 | 5 | 0 | 7 | 2.1 | O=C(COC(=O)c1cnccn1)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1588194 | 105406 | 6 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 321 | 5 | 0 | 7 | 2.1 | O=C(COC(=O)c1cnccn1)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| 6173110 | 217777 | 1 | None | 1 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 331 | 5 | 1 | 4 | 3.3 | COc1cccc(C(=O)N/N=C(/c2ccccc2)c2ccccn2)c1 | nan | ||
| CHEMBL3196139 | 217777 | 1 | None | 1 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 331 | 5 | 1 | 4 | 3.3 | COc1cccc(C(=O)N/N=C(/c2ccccc2)c2ccccn2)c1 | nan | ||
| 2351493 | 103026 | 1 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 301 | 4 | 1 | 3 | 3.3 | O=C(NN=C(c1ccccc1)c1ccccn1)c1ccccc1 | nan | ||
| CHEMBL1567294 | 103026 | 1 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 301 | 4 | 1 | 3 | 3.3 | O=C(NN=C(c1ccccc1)c1ccccn1)c1ccccc1 | nan | ||
| 11467216 | 241175 | 0 | None | None | None | Rabbit | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 567 | 15 | 1 | 10 | 5.2 | CCCCc1nc(Cl)c(COC(=O)CCCCO[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm049681p | ||
| CHEMBL360220 | 241175 | 0 | None | None | None | Rabbit | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 567 | 15 | 1 | 10 | 5.2 | CCCCc1nc(Cl)c(COC(=O)CCCCO[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm049681p | ||
| 135457059 | 104250 | 20 | None | -2 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 329 | 4 | 1 | 5 | 4.2 | Oc1cc(CSc2ccc(Cl)cc2)nc(-c2ccccn2)n1 | nan | ||
| CHEMBL1578482 | 104250 | 20 | None | -2 | 2 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 329 | 4 | 1 | 5 | 4.2 | Oc1cc(CSc2ccc(Cl)cc2)nc(-c2ccccn2)n1 | nan | ||
| 2303647 | 62085 | 5 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 262 | 3 | 2 | 4 | 3.1 | NNc1nc(-c2ccccc2)cc(-c2ccccc2)n1 | nan | ||
| CHEMBL1375248 | 62085 | 5 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 262 | 3 | 2 | 4 | 3.1 | NNc1nc(-c2ccccc2)cc(-c2ccccc2)n1 | nan | ||
| 11328757 | 470765 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 464 | 6 | 1 | 5 | 6.3 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(C)nc3ccccc23)cc1 | 10.1021/jm0603163 | ||
| CHEMBL84573 | 470765 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 464 | 6 | 1 | 5 | 6.3 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(C)nc3ccccc23)cc1 | 10.1021/jm0603163 | ||
| 9896251 | 199018 | 0 | None | 1 | 3 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 682 | 12 | 1 | 9 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1016/j.bmc.2012.06.011 | ||
| CHEMBL278176 | 199018 | 0 | None | 1 | 3 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 682 | 12 | 1 | 9 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1016/j.bmc.2012.06.011 | ||
| 9958963 | 474137 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 540 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL92821 | 474137 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 540 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971680 | 474270 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 520 | 10 | 1 | 7 | 6.1 | CCCCc1nn(-c2ccccc2C)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL93735 | 474270 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 520 | 10 | 1 | 7 | 6.1 | CCCCc1nn(-c2ccccc2C)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 57391456 | 143123 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 569 | 10 | 1 | 8 | 4.4 | CCCCc1nc(C)c(CCC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951142 | 143123 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 569 | 10 | 1 | 8 | 4.4 | CCCCc1nc(C)c(CCC(=O)N2CC(C)OC(C)C2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14971687 | 38714 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 430 | 9 | 2 | 6 | 4.4 | CCCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120716 | 38714 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 430 | 9 | 2 | 6 | 4.4 | CCCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956812 | 216336 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 463 | 8 | 1 | 7 | 4.1 | O=c1n(CCc2ccccc2)nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314333 | 216336 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 463 | 8 | 1 | 7 | 4.1 | O=c1n(CCc2ccccc2)nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 793621 | 60253 | 8 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 281 | 1 | 1 | 5 | 3.3 | CC1=NC(Nc2nc(C)c3ccccc3n2)=NC(C)(C)C1 | nan | ||
| CHEMBL1361034 | 60253 | 8 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 281 | 1 | 1 | 5 | 3.3 | CC1=NC(Nc2nc(C)c3ccccc3n2)=NC(C)(C)C1 | nan | ||
| 2420694 | 66670 | 3 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 360 | 3 | 3 | 3 | 4.8 | Cc1cccc(NC(S)=NNc2ncc(C(F)(F)F)cc2Cl)c1 | nan | ||
| CHEMBL1416497 | 66670 | 3 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 360 | 3 | 3 | 3 | 4.8 | Cc1cccc(NC(S)=NNc2ncc(C(F)(F)F)cc2Cl)c1 | nan | ||
| 1477595 | 97945 | 25 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 264 | 3 | 0 | 5 | 1.8 | O=[N+]([O-])c1ccc(S(=O)(=O)c2ccccc2)nc1 | nan | ||
| CHEMBL1520753 | 97945 | 25 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 264 | 3 | 0 | 5 | 1.8 | O=[N+]([O-])c1ccc(S(=O)(=O)c2ccccc2)nc1 | nan | ||
| 1336836 | 66631 | 8 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 398 | 5 | 0 | 6 | 4.5 | Cc1ccc2nc(C)cc(C(=O)OCC(=O)c3ccc(Cl)c([N+](=O)[O-])c3)c2c1 | nan | ||
| CHEMBL1416155 | 66631 | 8 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 398 | 5 | 0 | 6 | 4.5 | Cc1ccc2nc(C)cc(C(=O)OCC(=O)c3ccc(Cl)c([N+](=O)[O-])c3)c2c1 | nan | ||
| 135489943 | 217492 | 4 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 387 | 9 | 2 | 5 | 4.0 | CCCCN(CCCC)C(=S)N/N=C/c1c(C)nn(-c2ccccc2)c1O | nan | ||
| CHEMBL3192625 | 217492 | 4 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 387 | 9 | 2 | 5 | 4.0 | CCCCN(CCCC)C(=S)N/N=C/c1c(C)nn(-c2ccccc2)c1O | nan | ||
| 1139588 | 81812 | 9 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 363 | 5 | 0 | 6 | 3.2 | O=C(Cn1nnc2ccccc21)OCC(=O)c1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL1463168 | 81812 | 9 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 363 | 5 | 0 | 6 | 3.2 | O=C(Cn1nnc2ccccc21)OCC(=O)c1ccc(Cl)c(Cl)c1 | nan | ||
| 6873170 | 218072 | 9 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 249 | 2 | 1 | 3 | 1.2 | S=C(N/N=C/c1ccccc1)N1CCOCC1 | nan | ||
| CHEMBL3199234 | 218072 | 9 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 249 | 2 | 1 | 3 | 1.2 | S=C(N/N=C/c1ccccc1)N1CCOCC1 | nan | ||
| 804442 | 116687 | 35 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 289 | 4 | 1 | 2 | 3.7 | O=C(CNc1ccc(Br)cc1)c1ccccc1 | nan | ||
| CHEMBL1604367 | 116687 | 35 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 289 | 4 | 1 | 2 | 3.7 | O=C(CNc1ccc(Br)cc1)c1ccccc1 | nan | ||
| 929469 | 99831 | 8 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 287 | 5 | 0 | 7 | 1.4 | O=C(COC(=O)c1cnccn1)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1537991 | 99831 | 8 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 287 | 5 | 0 | 7 | 1.4 | O=C(COC(=O)c1cnccn1)c1cccc([N+](=O)[O-])c1 | nan | ||
| 3244543 | 431498 | 28 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 188 | 0 | 2 | 3 | 2.1 | Cc1cc(C)c2ccc(N)nc2c1O | nan | ||
| CHEMBL591834 | 431498 | 28 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 188 | 0 | 2 | 3 | 2.1 | Cc1cc(C)c2ccc(N)nc2c1O | nan | ||
| 43001 | 106000 | 20 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 230 | 1 | 1 | 4 | 2.0 | Nc1c(N2CCCC2)c2ccccc2oc1=O | nan | ||
| CHEMBL1594894 | 106000 | 20 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 230 | 1 | 1 | 4 | 2.0 | Nc1c(N2CCCC2)c2ccccc2oc1=O | nan | ||
| 788616 | 106288 | 5 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 269 | 5 | 1 | 4 | 2.8 | COC(=O)c1ccc(NCC(=O)c2ccccc2)cc1 | nan | ||
| CHEMBL1597563 | 106288 | 5 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 269 | 5 | 1 | 4 | 2.8 | COC(=O)c1ccc(NCC(=O)c2ccccc2)cc1 | nan | ||
| 2998385 | 58846 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 381 | 8 | 1 | 6 | 2.7 | CC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1 | nan | ||
| CHEMBL1347643 | 58846 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 381 | 8 | 1 | 6 | 2.7 | CC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1 | nan | ||
| 9549748 | 47064 | 7 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 287 | 1 | 1 | 1 | 4.4 | SC1=NCCc2ccccc2C1c1ccccc1Cl | nan | ||
| CHEMBL1331656 | 47064 | 7 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 287 | 1 | 1 | 1 | 4.4 | SC1=NCCc2ccccc2C1c1ccccc1Cl | nan | ||
| 2939261 | 45948 | 5 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 329 | 4 | 3 | 4 | 3.4 | CCC(C)c1ccc(O)c(NC(=S)NC(=O)c2cccnc2)c1 | nan | ||
| CHEMBL1322052 | 45948 | 5 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 329 | 4 | 3 | 4 | 3.4 | CCC(C)c1ccc(O)c(NC(=S)NC(=O)c2cccnc2)c1 | nan | ||
| 14956799 | 216555 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314590 | 216555 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956766 | 216634 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 471 | 7 | 1 | 7 | 4.5 | CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL315128 | 216634 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 471 | 7 | 1 | 7 | 4.5 | CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956813 | 473312 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 477 | 9 | 1 | 7 | 4.1 | O=c1n(CCc2ccccc2)nc(CC2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87330 | 473312 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 477 | 9 | 1 | 7 | 4.1 | O=c1n(CCc2ccccc2)nc(CC2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 44211606 | 201344 | 0 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 591 | 10 | 1 | 10 | 5.2 | CCCCc1nc2ccc(C3(C)CC(C(=O)OCC)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL295905 | 201344 | 0 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 591 | 10 | 1 | 10 | 5.2 | CCCCc1nc2ccc(C3(C)CC(C(=O)OCC)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 44246747 | 116495 | 5 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 429 | 3 | 2 | 5 | 3.2 | O=C1/C(=C/c2ccccc2)C[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)C1O5 | nan | ||
| 5310988 | 116495 | 5 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 429 | 3 | 2 | 5 | 3.2 | O=C1/C(=C/c2ccccc2)C[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)C1O5 | nan | ||
| CHEMBL1623128 | 116495 | 5 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 429 | 3 | 2 | 5 | 3.2 | O=C1/C(=C/c2ccccc2)C[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)C1O5 | nan | ||
| CHEMBL252172 | 116495 | 5 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 429 | 3 | 2 | 5 | 3.2 | O=C1/C(=C/c2ccccc2)C[C@@]2(O)[C@H]3Cc4ccc(O)c5c4[C@@]2(CCN3CC2CC2)C1O5 | nan | ||
| 135501733 | 80523 | 17 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 336 | 3 | 2 | 5 | 2.4 | Cc1nc(-n2nc3c(c2O)CCCC3)[nH]c(=O)c1Cc1ccccc1 | nan | ||
| CHEMBL1452116 | 80523 | 17 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 336 | 3 | 2 | 5 | 2.4 | Cc1nc(-n2nc3c(c2O)CCCC3)[nH]c(=O)c1Cc1ccccc1 | nan | ||
| 2898747 | 80231 | 10 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 418 | 6 | 0 | 7 | 1.8 | O=C(CN1C(=O)C2C3C=CC(C3)C2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1449757 | 80231 | 10 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 418 | 6 | 0 | 7 | 1.8 | O=C(CN1C(=O)C2C3C=CC(C3)C2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| 788619 | 98847 | 8 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 273 | 4 | 1 | 2 | 4.3 | Cc1ccc(C)c(NCC(=O)c2ccc(Cl)cc2)c1 | nan | ||
| CHEMBL1528883 | 98847 | 8 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 273 | 4 | 1 | 2 | 4.3 | Cc1ccc(C)c(NCC(=O)c2ccc(Cl)cc2)c1 | nan | ||
| 3648468 | 104740 | 5 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 373 | 4 | 1 | 3 | 4.6 | O=C(CNc1ccc(Br)cc1)c1ccc(Br)s1 | nan | ||
| CHEMBL1582697 | 104740 | 5 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 373 | 4 | 1 | 3 | 4.6 | O=C(CNc1ccc(Br)cc1)c1ccc(Br)s1 | nan | ||
| 135419079 | 63874 | 4 | None | -1 | 3 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 340 | 2 | 2 | 5 | 4.0 | Cc1[nH]c2ccccc2c1/C=C1\SC(=N)N(c2nccs2)C1=O | nan | ||
| CHEMBL1390716 | 63874 | 4 | None | -1 | 3 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 340 | 2 | 2 | 5 | 4.0 | Cc1[nH]c2ccccc2c1/C=C1\SC(=N)N(c2nccs2)C1=O | nan | ||
| 877472 | 80141 | 7 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 323 | 4 | 1 | 2 | 4.4 | O=C(CNc1cccc(Cl)c1)c1ccc(Br)cc1 | nan | ||
| CHEMBL1449035 | 80141 | 7 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 323 | 4 | 1 | 2 | 4.4 | O=C(CNc1cccc(Cl)c1)c1ccc(Br)cc1 | nan | ||
| 902793 | 86628 | 16 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 309 | 4 | 0 | 4 | 3.4 | O=C(COC(=O)c1ccncc1)c1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL1505893 | 86628 | 16 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 309 | 4 | 0 | 4 | 3.4 | O=C(COC(=O)c1ccncc1)c1ccc(Cl)c(Cl)c1 | nan | ||
| 67903280 | 369478 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 430 | 8 | 1 | 5 | 4.9 | CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4872989 | 369478 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 430 | 8 | 1 | 5 | 4.9 | CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 44355662 | 60136 | 0 | None | 125 | 2 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 506 | 6 | 1 | 5 | 6.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| CHEMBL135999 | 60136 | 0 | None | 125 | 2 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 506 | 6 | 1 | 5 | 6.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cc(Cl)c(Cl)cc2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| 10004013 | 235591 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 452 | 7 | 1 | 7 | 4.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(c2ccccc2)c2nnn[nH]2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL337217 | 235591 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 452 | 7 | 1 | 7 | 4.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(c2ccccc2)c2nnn[nH]2)cc1 | 10.1021/jm00078a014 | ||
| 14956744 | 470948 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2cccc(OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86255 | 470948 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2cccc(OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 1726745 | 47749 | 9 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 390 | 8 | 1 | 6 | 3.4 | O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)Nc1ccccc1Cl | nan | ||
| CHEMBL1337184 | 47749 | 9 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 390 | 8 | 1 | 6 | 3.4 | O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)Nc1ccccc1Cl | nan | ||
| 5731702 | 369917 | 7 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 277 | 3 | 1 | 3 | 4.1 | COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1 | nan | ||
| CHEMBL488140 | 369917 | 7 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 277 | 3 | 1 | 3 | 4.1 | COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1 | nan | ||
| 2476054 | 101157 | 2 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 347 | 3 | 3 | 4 | 3.9 | FC(F)(F)c1cnc(NN=C(S)Nc2cccnc2)c(Cl)c1 | nan | ||
| CHEMBL1549272 | 101157 | 2 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 347 | 3 | 3 | 4 | 3.9 | FC(F)(F)c1cnc(NN=C(S)Nc2cccnc2)c(Cl)c1 | nan | ||
| 2458676 | 65038 | 2 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 373 | 6 | 1 | 6 | 2.4 | CNS(=O)(=O)c1cccc(C(=O)OCC(=O)c2cc3ccccc3o2)c1 | nan | ||
| CHEMBL1402558 | 65038 | 2 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 373 | 6 | 1 | 6 | 2.4 | CNS(=O)(=O)c1cccc(C(=O)OCC(=O)c2cc3ccccc3o2)c1 | nan | ||
| 2221657 | 78007 | 9 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 353 | 2 | 0 | 5 | 3.6 | O=C1c2cccc3c([N+](=O)[O-])ccc(c23)C(=O)N1c1ccc(Cl)cn1 | nan | ||
| CHEMBL1428950 | 78007 | 9 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 353 | 2 | 0 | 5 | 3.6 | O=C1c2cccc3c([N+](=O)[O-])ccc(c23)C(=O)N1c1ccc(Cl)cn1 | nan | ||
| 44342039 | 24584 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 418 | 7 | 1 | 3 | 5.7 | CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL116170 | 24584 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 418 | 7 | 1 | 3 | 5.7 | CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 2426360 | 100156 | 3 | None | -8 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 382 | 3 | 3 | 3 | 4.6 | Fc1ccc(N=C(S)NNc2ncc(C(F)(F)F)cc2Cl)c(F)c1 | nan | ||
| CHEMBL1540808 | 100156 | 3 | None | -8 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 382 | 3 | 3 | 3 | 4.6 | Fc1ccc(N=C(S)NNc2ncc(C(F)(F)F)cc2Cl)c(F)c1 | nan | ||
| 9653239 | 217281 | 6 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 291 | 3 | 2 | 4 | 2.7 | O=C(N/N=C/c1cccc2cccnc12)c1ccccc1O | nan | ||
| CHEMBL3190198 | 217281 | 6 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 291 | 3 | 2 | 4 | 2.7 | O=C(N/N=C/c1cccc2cccnc12)c1ccccc1O | nan | ||
| 5730138 | 78285 | 10 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 307 | 4 | 1 | 4 | 4.1 | COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC | nan | ||
| CHEMBL1431014 | 78285 | 10 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 307 | 4 | 1 | 4 | 4.1 | COc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC | nan | ||
| 12005285 | 106278 | 5 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 402 | 8 | 1 | 9 | 4.0 | CC(=O)OCCCNc1cc(Sc2ccc(C)cc2)c2nonc2c1[N+](=O)[O-] | nan | ||
| CHEMBL1597454 | 106278 | 5 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 402 | 8 | 1 | 9 | 4.0 | CC(=O)OCCCNc1cc(Sc2ccc(C)cc2)c2nonc2c1[N+](=O)[O-] | nan | ||
| 1767917 | 64865 | 8 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 375 | 5 | 3 | 4 | 2.2 | Cc1nn(CCC(=O)NNC(S)=NCC(C)C)c(C)c1Br | nan | ||
| CHEMBL1401122 | 64865 | 8 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 375 | 5 | 3 | 4 | 2.2 | Cc1nn(CCC(=O)NNC(S)=NCC(C)C)c(C)c1Br | nan | ||
| 14956806 | 216586 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 497 | 10 | 1 | 8 | 5.0 | CCCCc1nn(CSc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314810 | 216586 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 497 | 10 | 1 | 8 | 5.0 | CCCCc1nn(CSc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956768 | 216626 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 499 | 8 | 1 | 7 | 5.2 | CC(C)CCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL315077 | 216626 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 499 | 8 | 1 | 7 | 5.2 | CC(C)CCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956745 | 473248 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccc(C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86906 | 473248 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccc(C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14951062 | 473358 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 429 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CC2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87669 | 473358 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 429 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CC2CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 131590 | 44552 | 36 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.6019/CHEMBL5442687 | ||
| CHEMBL130896 | 44552 | 36 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.6019/CHEMBL5442687 | ||
| 14971694 | 38596 | 0 | None | None | None | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120605 | 38596 | 0 | None | None | None | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1n[nH]c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 44355660 | 45398 | 0 | None | 89 | 2 | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 483 | 7 | 1 | 7 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| CHEMBL131676 | 45398 | 0 | None | 89 | 2 | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 483 | 7 | 1 | 7 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2cccc([N+](=O)[O-])c2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| 10410730 | 58314 | 0 | None | 6 | 2 | Rabbit | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 | 10.1021/jm00078a013 | ||
| CHEMBL134307 | 58314 | 0 | None | 6 | 2 | Rabbit | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1cccc(C)c1 | 10.1021/jm00078a013 | ||
| 2898434 | 116728 | 11 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 406 | 6 | 0 | 7 | 1.9 | O=C(CN1C(=O)C2CC=CCC2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1604741 | 116728 | 11 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 406 | 6 | 0 | 7 | 1.9 | O=C(CN1C(=O)C2CC=CCC2C1=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| 3532334 | 85770 | 9 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 303 | 2 | 1 | 4 | 3.2 | O=c1c2cc(Cl)ccc2[nH]c(=S)n1Cc1ccccn1 | nan | ||
| CHEMBL1498428 | 85770 | 9 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 303 | 2 | 1 | 4 | 3.2 | O=c1c2cc(Cl)ccc2[nH]c(=S)n1Cc1ccccn1 | nan | ||
| 2640418 | 45981 | 4 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 377 | 6 | 0 | 6 | 2.5 | O=C(COC(=O)c1ccco1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 | nan | ||
| CHEMBL1322344 | 45981 | 4 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 377 | 6 | 0 | 6 | 2.5 | O=C(COC(=O)c1ccco1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 | nan | ||
| 5687785 | 218014 | 1 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 346 | 5 | 1 | 5 | 3.2 | O=C(N/N=C(\c1ccccc1)c1ccccn1)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL3198576 | 218014 | 1 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 346 | 5 | 1 | 5 | 3.2 | O=C(N/N=C(\c1ccccc1)c1ccccn1)c1cccc([N+](=O)[O-])c1 | nan | ||
| 5735740 | 85072 | 8 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 321 | 5 | 1 | 4 | 4.5 | CCOc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC | nan | ||
| CHEMBL1491932 | 85072 | 8 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 321 | 5 | 1 | 4 | 4.5 | CCOc1cccc(/C=C/c2ccc3cccc(O)c3n2)c1OC | nan | ||
| 2320855 | 80019 | 4 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 333 | 4 | 4 | 7 | 0.6 | O=C1OCC(CO)(CO)N=C1NNc1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL1448161 | 80019 | 4 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 333 | 4 | 4 | 7 | 0.6 | O=C1OCC(CO)(CO)N=C1NNc1ccc(Cl)c(Cl)c1 | nan | ||
| 5091521 | 58987 | 6 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 402 | 2 | 2 | 9 | 2.9 | CC1(C)Cc2c(c(N3CCOCC3)nc3sc4c(NN)ncnc4c23)CS1 | nan | ||
| CHEMBL1348954 | 58987 | 6 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 402 | 2 | 2 | 9 | 2.9 | CC1(C)Cc2c(c(N3CCOCC3)nc3sc4c(NN)ncnc4c23)CS1 | nan | ||
| 2121806 | 85485 | 3 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 266 | 4 | 1 | 6 | 2.3 | CCSc1nnc(NC(=O)c2ccccn2)s1 | nan | ||
| CHEMBL1495849 | 85485 | 3 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 266 | 4 | 1 | 6 | 2.3 | CCSc1nnc(NC(=O)c2ccccn2)s1 | nan | ||
| 2733001 | 62951 | 2 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 288 | 5 | 1 | 4 | 3.7 | Cc1ccc(C(C[N+](=O)[O-])Sc2ccc(N)cc2)cc1 | nan | ||
| CHEMBL1382939 | 62951 | 2 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 288 | 5 | 1 | 4 | 3.7 | Cc1ccc(C(C[N+](=O)[O-])Sc2ccc(N)cc2)cc1 | nan | ||
| 25162518 | 83291 | 3 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 417 | 8 | 0 | 6 | 2.7 | O=C(COc1ccccc1)OCC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1 | nan | ||
| CHEMBL1477291 | 83291 | 3 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 417 | 8 | 0 | 6 | 2.7 | O=C(COc1ccccc1)OCC(=O)c1ccc(S(=O)(=O)N2CCCCC2)cc1 | nan | ||
| 14956784 | 216222 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 447 | 9 | 1 | 9 | 2.5 | CCCCc1nn(CC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314179 | 216222 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 447 | 9 | 1 | 9 | 2.5 | CCCCc1nn(CC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956764 | 470864 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 541 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85541 | 470864 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 541 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 44355628 | 58599 | 0 | None | 5 | 2 | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 508 | 6 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O | 10.1021/jm00078a013 | ||
| CHEMBL134567 | 58599 | 0 | None | 5 | 2 | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 508 | 6 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2Cc1cc(Cl)c(Cl)cc1C(=O)O | 10.1021/jm00078a013 | ||
| 10095493 | 59736 | 0 | None | 93 | 2 | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 454 | 6 | 0 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 | 10.1021/jm00078a013 | ||
| CHEMBL135521 | 59736 | 0 | None | 93 | 2 | Rabbit | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 454 | 6 | 0 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)OC)c1ccccc1 | 10.1021/jm00078a013 | ||
| 1336623 | 81738 | 17 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 350 | 5 | 0 | 6 | 3.5 | Cc1cc(C(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)c2ccccc2n1 | nan | ||
| CHEMBL1462517 | 81738 | 17 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 350 | 5 | 0 | 6 | 3.5 | Cc1cc(C(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)c2ccccc2n1 | nan | ||
| 2165745 | 78172 | 7 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 425 | 8 | 1 | 8 | 0.7 | O=C(CN1C(=O)c2ccccc2C1=O)NCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1430172 | 78172 | 7 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 425 | 8 | 1 | 8 | 0.7 | O=C(CN1C(=O)c2ccccc2C1=O)NCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 659805 | 45799 | 5 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 302 | 1 | 2 | 4 | 3.7 | ON1C(c2ccc(Cl)cc2Cl)N(O)[C@@H]2CCCC[C@@H]21 | nan | ||
| CHEMBL1320678 | 45799 | 5 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 302 | 1 | 2 | 4 | 3.7 | ON1C(c2ccc(Cl)cc2Cl)N(O)[C@@H]2CCCC[C@@H]21 | nan | ||
| 135415440 | 426136 | 12 | None | -10 | 4 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 295 | 3 | 2 | 6 | 3.0 | Cc1ccc(Nc2cc(C)nn2-c2nc(C)cc(O)n2)cc1 | nan | ||
| CHEMBL586135 | 426136 | 12 | None | -10 | 4 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 295 | 3 | 2 | 6 | 3.0 | Cc1ccc(Nc2cc(C)nn2-c2nc(C)cc(O)n2)cc1 | nan | ||
| 579121 | 102376 | 9 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 377 | 4 | 1 | 4 | 4.7 | COc1ccc(NC2(c3ccc(Cl)cc3)C(=O)c3ccccc3C2=O)cc1 | nan | ||
| CHEMBL1561907 | 102376 | 9 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 377 | 4 | 1 | 4 | 4.7 | COc1ccc(NC2(c3ccc(Cl)cc3)C(=O)c3ccccc3C2=O)cc1 | nan | ||
| 24983202 | 61480 | 3 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 444 | 7 | 1 | 6 | 2.9 | CC(=O)Nc1cccc(C(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)c1 | nan | ||
| CHEMBL1371002 | 61480 | 3 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 444 | 7 | 1 | 6 | 2.9 | CC(=O)Nc1cccc(C(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)c1 | nan | ||
| 14971686 | 39146 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 507 | 10 | 1 | 8 | 5.2 | CCCCc1nn(-c2ccccn2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL121125 | 39146 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 507 | 10 | 1 | 8 | 5.2 | CCCCc1nn(-c2ccccn2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10414429 | 234932 | 0 | None | 363 | 2 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 522 | 5 | 1 | 5 | 5.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)ccc(Cl)c1C(=O)O | 10.1021/jm00078a013 | ||
| CHEMBL335535 | 234932 | 0 | None | 363 | 2 | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 522 | 5 | 1 | 5 | 5.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1c(Cl)ccc(Cl)c1C(=O)O | 10.1021/jm00078a013 | ||
| 10322211 | 334048 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 464 | 6 | 1 | 7 | 4.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(c1ccccc1)c1nnn[nH]1 | 10.1021/jm00078a013 | ||
| CHEMBL442963 | 334048 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 464 | 6 | 1 | 7 | 4.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(c1ccccc1)c1nnn[nH]1 | 10.1021/jm00078a013 | ||
| 14956741 | 216703 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL315615 | 216703 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 44292094 | 201567 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 585 | 9 | 1 | 9 | 6.4 | CCCCc1nc2ccc(C3CC(c4cc(C)co4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL297583 | 201567 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 585 | 9 | 1 | 9 | 6.4 | CCCCc1nc2ccc(C3CC(c4cc(C)co4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 23205 | 235794 | 35 | None | -7 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 262 | 0 | 1 | 4 | 1.2 | C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](O)[C@H]12 | nan | ||
| CHEMBL338474 | 235794 | 35 | None | -7 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 262 | 0 | 1 | 4 | 1.2 | C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](O)[C@H]12 | nan | ||
| 24981067 | 98487 | 3 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 480 | 8 | 1 | 7 | 1.8 | CNS(=O)(=O)c1cccc(C(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)c1 | nan | ||
| CHEMBL1525764 | 98487 | 3 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 480 | 8 | 1 | 7 | 1.8 | CNS(=O)(=O)c1cccc(C(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)c1 | nan | ||
| 768473 | 103210 | 5 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 267 | 6 | 0 | 2 | 3.9 | CCN(CC)CC(=O)c1ccc(-c2ccccc2)cc1 | nan | ||
| CHEMBL1568922 | 103210 | 5 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 267 | 6 | 0 | 2 | 3.9 | CCN(CC)CC(=O)c1ccc(-c2ccccc2)cc1 | nan | ||
| 4799115 | 58226 | 5 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 332 | 3 | 2 | 4 | 4.1 | O=C(Nc1nc(-c2ccccn2)cs1)Nc1ccc(F)cc1F | nan | ||
| CHEMBL1342423 | 58226 | 5 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 332 | 3 | 2 | 4 | 4.1 | O=C(Nc1nc(-c2ccccn2)cs1)Nc1ccc(F)cc1F | nan | ||
| 11957260 | 66635 | 5 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 389 | 6 | 2 | 10 | 3.3 | O=[N+]([O-])c1c(NCCO)cc(Sc2nc3ccccc3s2)c2nonc12 | nan | ||
| CHEMBL1416184 | 66635 | 5 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 389 | 6 | 2 | 10 | 3.3 | O=[N+]([O-])c1c(NCCO)cc(Sc2nc3ccccc3s2)c2nonc12 | nan | ||
| 1610 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| 3941 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| 3961 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| CHEMBL191 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| 10069786 | 333714 | 3 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 404 | 7 | 1 | 3 | 5.3 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL439968 | 333714 | 3 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 404 | 7 | 1 | 3 | 5.3 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 10393397 | 46628 | 0 | None | 6 | 2 | Rabbit | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 578 | 8 | 1 | 5 | 7.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL132807 | 46628 | 0 | None | 6 | 2 | Rabbit | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 578 | 8 | 1 | 5 | 7.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 | 10.1021/jm00078a014 | ||
| 568849 | 65348 | 4 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 313 | 7 | 0 | 5 | 3.0 | O=C(CCc1ccccc1)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1405657 | 65348 | 4 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 313 | 7 | 0 | 5 | 3.0 | O=C(CCc1ccccc1)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 5720743 | 217863 | 7 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 257 | 3 | 1 | 3 | 2.4 | C/C(=N\NC(=O)c1ccc(F)cc1)c1ccccn1 | nan | ||
| CHEMBL3197070 | 217863 | 7 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 257 | 3 | 1 | 3 | 2.4 | C/C(=N\NC(=O)c1ccc(F)cc1)c1ccccn1 | nan | ||
| 761850 | 82244 | 8 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 300 | 5 | 0 | 6 | 2.3 | Cc1ccc(C(=O)COC(=O)c2ccncc2)cc1[N+](=O)[O-] | nan | ||
| CHEMBL1466556 | 82244 | 8 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 300 | 5 | 0 | 6 | 2.3 | Cc1ccc(C(=O)COC(=O)c2ccncc2)cc1[N+](=O)[O-] | nan | ||
| 142534050 | 331774 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 545 | 11 | 1 | 7 | 5.2 | CCCCc1nc(C)c(CC(=S)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4287379 | 331774 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 545 | 11 | 1 | 7 | 5.2 | CCCCc1nc(C)c(CC(=S)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 14971712 | 199800 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 402 | 8 | 3 | 5 | 3.9 | CCCCc1n[nH]c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL283975 | 199800 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 402 | 8 | 3 | 5 | 3.9 | CCCCc1n[nH]c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956756 | 473339 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 529 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2ccccc2Br)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87513 | 473339 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 529 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2ccccc2Br)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 20081627 | 182962 | 0 | None | -1 | 2 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 502 | 6 | 2 | 7 | 4.7 | CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL24224 | 182962 | 0 | None | -1 | 2 | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 502 | 6 | 2 | 7 | 4.7 | CC1CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| 44459871 | 183338 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 573 | 8 | 1 | 8 | 4.2 | CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)CCC1=O | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL24319 | 183338 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 573 | 8 | 1 | 8 | 4.2 | CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)CCC1=O | 10.1016/S0960-894X(01)80348-6 | ||
| 44459655 | 184029 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 575 | 9 | 1 | 8 | 4.3 | CCCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL24478 | 184029 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 575 | 9 | 1 | 8 | 4.3 | CCCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | ||
| 44459835 | 332777 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 587 | 8 | 1 | 8 | 4.5 | CC1CC(=O)N(CC(=O)N(C)C)N=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL432271 | 332777 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 587 | 8 | 1 | 8 | 4.5 | CC1CC(=O)N(CC(=O)N(C)C)N=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| 44459654 | 332839 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 601 | 8 | 1 | 8 | 4.9 | CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)(C)CC1=O | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL432847 | 332839 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 601 | 8 | 1 | 8 | 4.9 | CN(C)C(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)(C)CC1=O | 10.1016/S0960-894X(01)80348-6 | ||
| 22942227 | 143110 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 569 | 10 | 1 | 9 | 3.5 | CCCCc1nc(C)c(CC(=O)N2CCC[C@H]2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951130 | 143110 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 569 | 10 | 1 | 9 | 3.5 | CCCCc1nc(C)c(CC(=O)N2CCC[C@H]2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 22942226 | 143111 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 554 | 10 | 2 | 8 | 2.8 | CCCCc1nc(C)c(CC(=O)N2CCC[C@H]2C(N)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951131 | 143111 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 554 | 10 | 2 | 8 | 2.8 | CCCCc1nc(C)c(CC(=O)N2CCC[C@H]2C(N)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 142534121 | 331534 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 559 | 11 | 1 | 7 | 5.4 | CCCCc1nc(C)c(CC(=S)N(C)CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4282931 | 331534 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 559 | 11 | 1 | 7 | 5.4 | CCCCc1nc(C)c(CC(=S)N(C)CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 14971638 | 233869 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.5 | CCCCc1nc(-c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL334192 | 233869 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.5 | CCCCc1nc(-c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 9845644 | 473400 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 431 | 9 | 1 | 7 | 4.3 | CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87964 | 473400 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 431 | 9 | 1 | 7 | 4.3 | CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956779 | 140932 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 445 | 8 | 1 | 7 | 4.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL19202 | 140932 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 445 | 8 | 1 | 7 | 4.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 142533975 | 331851 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 571 | 10 | 1 | 7 | 5.7 | CCCCc1nc(C(C)C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4288964 | 331851 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 571 | 10 | 1 | 7 | 5.7 | CCCCc1nc(C(C)C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 155517399 | 334739 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 557 | 10 | 1 | 6 | 6.8 | CCCCC1=NC(C(C)C)=C(CC(=S)N2CCCC2)CN1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.12.043 | ||
| CHEMBL4444760 | 334739 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 557 | 10 | 1 | 6 | 6.8 | CCCCC1=NC(C(C)C)=C(CC(=S)N2CCCC2)CN1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.12.043 | ||
| 14971699 | 222257 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2cccc(Cl)c2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL330571 | 222257 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2cccc(Cl)c2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 44213343 | 143106 | 33 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 485 | 9 | 1 | 7 | 3.4 | CCCCc1nc(C)c(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951126 | 143106 | 33 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 485 | 9 | 1 | 7 | 3.4 | CCCCc1nc(C)c(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 9935106 | 137582 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL18287 | 137582 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 44213346 | 143112 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 525 | 9 | 1 | 7 | 4.3 | CCCCc1nc(C)c(CC(=O)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951132 | 143112 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 525 | 9 | 1 | 7 | 4.3 | CCCCc1nc(C)c(CC(=O)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14971709 | 39239 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 553 | 11 | 2 | 9 | 5.3 | CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL121416 | 39239 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 553 | 11 | 2 | 9 | 5.3 | CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 57401930 | 143100 | 1 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 500 | 11 | 1 | 8 | 4.3 | CCCCc1nc(C)c(CCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951120 | 143100 | 1 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 500 | 11 | 1 | 8 | 4.3 | CCCCc1nc(C)c(CCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 44213342 | 143103 | 22 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 458 | 9 | 2 | 7 | 3.4 | CCCCc1nc(C)c(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951123 | 143103 | 22 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 458 | 9 | 2 | 7 | 3.4 | CCCCc1nc(C)c(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14971713 | 332730 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 430 | 9 | 2 | 6 | 4.4 | CCCCc1nn(CC)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL431887 | 332730 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 430 | 9 | 2 | 6 | 4.4 | CCCCc1nn(CC)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 57393227 | 143114 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 543 | 9 | 1 | 8 | 3.9 | CCCCc1nc(C)c(CC(=O)N2CCSCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951134 | 143114 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 543 | 9 | 1 | 8 | 3.9 | CCCCc1nc(C)c(CC(=O)N2CCSCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 108185 | 3317 | 57 | None | -3 | 4 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00075a014 | ||
| 586 | 3317 | 57 | None | -3 | 4 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00075a014 | ||
| CHEMBL907 | 3317 | 57 | None | -3 | 4 | Rabbit | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00075a014 | ||
| 14971697 | 221039 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.4 | CCCCc1nn(-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL327982 | 221039 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 478 | 9 | 2 | 6 | 5.4 | CCCCc1nn(-c2ccccc2)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10298977 | 473297 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 471 | 9 | 1 | 7 | 4.9 | CCCCc1nn(CC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87239 | 473297 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 471 | 9 | 1 | 7 | 4.9 | CCCCc1nn(CC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 131654 | 473370 | 11 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87778 | 473370 | 11 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 1481 | 7955 | 73 | None | -8 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.6019/CHEMBL5442687 | ||
| 3749 | 7955 | 73 | None | -8 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.6019/CHEMBL5442687 | ||
| 6908 | 7955 | 73 | None | -8 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.6019/CHEMBL5442687 | ||
| CHEMBL1513 | 7955 | 73 | None | -8 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.6019/CHEMBL5442687 | ||
| 14971683 | 38762 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 536 | 11 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120750 | 38762 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 536 | 11 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccc(OC)cc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971692 | 222411 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 560 | 9 | 1 | 7 | 6.7 | CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL331078 | 222411 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 560 | 9 | 1 | 7 | 6.7 | CCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10026868 | 47679 | 0 | None | 331 | 2 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 452 | 5 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| CHEMBL133653 | 47679 | 0 | None | 331 | 2 | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 452 | 5 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| 14956766 | 216634 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 471 | 7 | 1 | 7 | 4.5 | CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL315128 | 216634 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 471 | 7 | 1 | 7 | 4.5 | CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 2540 | 18749 | 72 | None | -28 | 3 | Rabbit | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 475 | 18749 | 72 | None | -28 | 3 | Rabbit | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL1014 | 18749 | 72 | None | -28 | 3 | Rabbit | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| DB00796 | 18749 | 72 | None | -28 | 3 | Rabbit | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 10409549 | 234913 | 0 | None | 104 | 2 | Rabbit | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 414 | 7 | 2 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL335514 | 234913 | 0 | None | 104 | 2 | Rabbit | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 414 | 7 | 2 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| 10345459 | 235660 | 0 | None | 43 | 2 | Rabbit | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 490 | 9 | 1 | 5 | 5.8 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1cc(F)ccc1F | 10.1021/jm00078a014 | ||
| CHEMBL337663 | 235660 | 0 | None | 43 | 2 | Rabbit | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 490 | 9 | 1 | 5 | 5.8 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1cc(F)ccc1F | 10.1021/jm00078a014 | ||
| 25163176 | 97383 | 3 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 431 | 8 | 0 | 6 | 2.8 | COc1ccc(CC(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)cc1 | nan | ||
| CHEMBL1514866 | 97383 | 3 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 431 | 8 | 0 | 6 | 2.8 | COc1ccc(CC(=O)OCC(=O)c2ccc(S(=O)(=O)N3CCCCC3)cc2)cc1 | nan | ||
| 3116640 | 44257 | 9 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 542 | 6 | 0 | 7 | 2.1 | O=C(CN1C(=O)C2C3CC(C(Br)C3Br)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1306605 | 44257 | 9 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 542 | 6 | 0 | 7 | 2.1 | O=C(CN1C(=O)C2C3CC(C(Br)C3Br)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 1653162 | 103236 | 8 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 335 | 3 | 3 | 5 | 1.7 | COc1ccccc1C(=O)NNC(=S)NC(=O)c1cccs1 | nan | ||
| CHEMBL1569107 | 103236 | 8 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 335 | 3 | 3 | 5 | 1.7 | COc1ccccc1C(=O)NNC(=S)NC(=O)c1cccs1 | nan | ||
| 11957180 | 46574 | 5 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 403 | 7 | 2 | 10 | 3.7 | O=[N+]([O-])c1c(NCCCO)cc(Sc2nc3ccccc3s2)c2nonc12 | nan | ||
| CHEMBL1327721 | 46574 | 5 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 403 | 7 | 2 | 10 | 3.7 | O=[N+]([O-])c1c(NCCCO)cc(Sc2nc3ccccc3s2)c2nonc12 | nan | ||
| 11957209 | 86450 | 5 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 445 | 8 | 1 | 11 | 4.3 | CC(=O)OCCCNc1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] | nan | ||
| CHEMBL1504429 | 86450 | 5 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 445 | 8 | 1 | 11 | 4.3 | CC(=O)OCCCNc1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] | nan | ||
| 9550611 | 103005 | 5 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 403 | 6 | 1 | 10 | 3.3 | CN(CCO)c1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] | nan | ||
| CHEMBL1567159 | 103005 | 5 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 403 | 6 | 1 | 10 | 3.3 | CN(CCO)c1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] | nan | ||
| 780302 | 65510 | 5 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 340 | 3 | 2 | 4 | 3.9 | NNc1nc(-c2ccccc2)cc(-c2ccc(Br)cc2)n1 | nan | ||
| CHEMBL1407100 | 65510 | 5 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 340 | 3 | 2 | 4 | 3.9 | NNc1nc(-c2ccccc2)cc(-c2ccc(Br)cc2)n1 | nan | ||
| 14971681 | 221019 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL327862 | 221019 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956771 | 473325 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 482 | 8 | 1 | 9 | 3.8 | CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87392 | 473325 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 482 | 8 | 1 | 9 | 3.8 | CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956750 | 470872 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccc(F)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85596 | 470872 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccc(F)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 2412928 | 45555 | 4 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 500 | 7 | 1 | 11 | 1.5 | Cn1c(N)c(C(=O)COC(=O)c2ccccc2C(=O)c2ccc(Cl)c([N+](=O)[O-])c2)c(=O)n(C)c1=O | nan | ||
| CHEMBL1318653 | 45555 | 4 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 500 | 7 | 1 | 11 | 1.5 | Cn1c(N)c(C(=O)COC(=O)c2ccccc2C(=O)c2ccc(Cl)c([N+](=O)[O-])c2)c(=O)n(C)c1=O | nan | ||
| 6418891 | 46645 | 9 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 401 | 3 | 0 | 4 | 5.7 | FC(F)(F)c1cccc(Sc2nc(-c3ccccc3)nnc2C(F)(F)F)c1 | nan | ||
| CHEMBL1328168 | 46645 | 9 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 401 | 3 | 0 | 4 | 5.7 | FC(F)(F)c1cccc(Sc2nc(-c3ccccc3)nnc2C(F)(F)F)c1 | nan | ||
| 2815589 | 85095 | 2 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 272 | 5 | 2 | 3 | 2.2 | NC(=O)c1ccccc1NCC(=O)c1ccc(F)cc1 | nan | ||
| CHEMBL1492089 | 85095 | 2 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 272 | 5 | 2 | 3 | 2.2 | NC(=O)c1ccccc1NCC(=O)c1ccc(F)cc1 | nan | ||
| 16436605 | 81911 | 7 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 486 | 6 | 1 | 7 | 2.6 | CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N3CCCC(C)C3)cc2)n1 | nan | ||
| CHEMBL1464024 | 81911 | 7 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 486 | 6 | 1 | 7 | 2.6 | CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N3CCCC(C)C3)cc2)n1 | nan | ||
| 11159916 | 251910 | 3 | None | None | None | Rabbit | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 197 | 4 | 1 | 4 | 1.1 | O=C(O)c1cccc(CO[N+](=O)[O-])c1 | 10.1021/jm049681p | ||
| CHEMBL362550 | 251910 | 3 | None | None | None | Rabbit | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 197 | 4 | 1 | 4 | 1.1 | O=C(O)c1cccc(CO[N+](=O)[O-])c1 | 10.1021/jm049681p | ||
| 442142 | 368760 | 19 | None | -4 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 304 | 1 | 0 | 5 | 1.8 | C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(C)=O)[C@H]12 | nan | ||
| CHEMBL486196 | 368760 | 19 | None | -4 | 2 | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 304 | 1 | 0 | 5 | 1.8 | C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(C)=O)[C@H]12 | nan | ||
| 53317942 | 120393 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 444 | 7 | 1 | 7 | 3.3 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL1667999 | 120393 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 444 | 7 | 1 | 7 | 3.3 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | ||
| 14971695 | 38771 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 506 | 10 | 1 | 7 | 5.5 | CCCc1nn(Cc2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120762 | 38771 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 506 | 10 | 1 | 7 | 5.5 | CCCc1nn(Cc2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 44292181 | 201298 | 0 | None | None | None | Bovine | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL295529 | 201298 | 0 | None | None | None | Bovine | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 9982177 | 60173 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 470 | 9 | 1 | 5 | 5.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC(C)C)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL136028 | 60173 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 470 | 9 | 1 | 5 | 5.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC(C)C)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| 10275744 | 470903 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 451 | 8 | 1 | 7 | 4.3 | CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85876 | 470903 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 451 | 8 | 1 | 7 | 4.3 | CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 2939837 | 80731 | 5 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 363 | 2 | 3 | 4 | 3.9 | CC(C)(C)c1cc(Cl)c(O)c(NC(=S)NC(=O)c2cccnc2)c1 | nan | ||
| CHEMBL1453857 | 80731 | 5 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 363 | 2 | 3 | 4 | 3.9 | CC(C)(C)c1cc(Cl)c(O)c(NC(=S)NC(=O)c2cccnc2)c1 | nan | ||
| 800048 | 58181 | 25 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 252 | 2 | 0 | 4 | 2.6 | CCn1c(=O)c([N+](=O)[O-])c(Cl)c2ccccc21 | nan | ||
| CHEMBL1342053 | 58181 | 25 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 252 | 2 | 0 | 4 | 2.6 | CCn1c(=O)c([N+](=O)[O-])c(Cl)c2ccccc21 | nan | ||
| 972880 | 386845 | 7 | None | 1 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 268 | 3 | 1 | 5 | 3.7 | Cc1cccnc1Nc1nc(-c2ccccn2)cs1 | nan | ||
| CHEMBL528694 | 386845 | 7 | None | 1 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 268 | 3 | 1 | 5 | 3.7 | Cc1cccnc1Nc1nc(-c2ccccn2)cs1 | nan | ||
| 9660957 | 144969 | 9 | None | -1 | 4 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 330 | 4 | 0 | 5 | 2.3 | CCn1c(Cl)c(C=O)s/c1=N\S(=O)(=O)c1ccccc1 | nan | ||
| CHEMBL1999049 | 144969 | 9 | None | -1 | 4 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 330 | 4 | 0 | 5 | 2.3 | CCn1c(Cl)c(C=O)s/c1=N\S(=O)(=O)c1ccccc1 | nan | ||
| 1472225 | 58439 | 9 | None | -5 | 5 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 398 | 6 | 1 | 4 | 3.9 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(C)cc2)cn1 | nan | ||
| CHEMBL1344225 | 58439 | 9 | None | -5 | 5 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 398 | 6 | 1 | 4 | 3.9 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(C)cc2)cn1 | nan | ||
| 3734285 | 99883 | 12 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 399 | 7 | 1 | 4 | 4.8 | CN(C)CCCNC(=O)c1ccc(-c2nc(-c3ccc(Cl)cc3)cs2)cc1 | nan | ||
| CHEMBL1538399 | 99883 | 12 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 399 | 7 | 1 | 4 | 4.8 | CN(C)CCCNC(=O)c1ccc(-c2nc(-c3ccc(Cl)cc3)cs2)cc1 | nan | ||
| 5335941 | 217535 | 8 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 279 | 2 | 2 | 2 | 3.4 | CC1CC2=C(CC1/C=N/NC(N)=S)C(C)(C)CCC2 | nan | ||
| CHEMBL3193181 | 217535 | 8 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 279 | 2 | 2 | 2 | 3.4 | CC1CC2=C(CC1/C=N/NC(N)=S)C(C)(C)CCC2 | nan | ||
| 9590741 | 217475 | 7 | None | -2 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 273 | 3 | 1 | 3 | 2.9 | C/C(=N\NC(=O)c1ccc(Cl)cc1)c1ccccn1 | nan | ||
| CHEMBL3192432 | 217475 | 7 | None | -2 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 273 | 3 | 1 | 3 | 2.9 | C/C(=N\NC(=O)c1ccc(Cl)cc1)c1ccccn1 | nan | ||
| 2539399 | 83328 | 4 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 392 | 4 | 2 | 5 | 2.4 | Cc1cc(C)nc(NNS(=O)(=O)c2c(F)cc(F)cc2Br)n1 | nan | ||
| CHEMBL1477553 | 83328 | 4 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 392 | 4 | 2 | 5 | 2.4 | Cc1cc(C)nc(NNS(=O)(=O)c2c(F)cc(F)cc2Br)n1 | nan | ||
| 11159916 | 251910 | 3 | None | None | None | Rabbit | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 197 | 4 | 1 | 4 | 1.1 | O=C(O)c1cccc(CO[N+](=O)[O-])c1 | 10.1021/jm049681p | ||
| CHEMBL362550 | 251910 | 3 | None | None | None | Rabbit | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 197 | 4 | 1 | 4 | 1.1 | O=C(O)c1cccc(CO[N+](=O)[O-])c1 | 10.1021/jm049681p | ||
| 2283939 | 97700 | 8 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 404 | 8 | 1 | 6 | 3.7 | Cc1ccc(C(=O)COC(=O)CCC(=O)Nc2ccccc2Cl)cc1[N+](=O)[O-] | nan | ||
| CHEMBL1518619 | 97700 | 8 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 404 | 8 | 1 | 6 | 3.7 | Cc1ccc(C(=O)COC(=O)CCC(=O)Nc2ccccc2Cl)cc1[N+](=O)[O-] | nan | ||
| 14971685 | 312440 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 582 | 11 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL406791 | 312440 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 582 | 11 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10113613 | 216420 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 431 | 7 | 1 | 7 | 4.0 | CCCCc1nn(C(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314436 | 216420 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 431 | 7 | 1 | 7 | 4.0 | CCCCc1nn(C(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956797 | 473386 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87885 | 473386 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10048776 | 234205 | 0 | None | None | None | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 438 | 6 | 1 | 5 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| CHEMBL334622 | 234205 | 0 | None | None | None | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 438 | 6 | 1 | 5 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)O)c1 | 10.1021/jm00078a013 | ||
| 1096078 | 102861 | 2 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 364 | 4 | 1 | 4 | 4.2 | COc1ccc(NS(=O)(=O)c2ccc3ccccc3c2)c2ncccc12 | nan | ||
| CHEMBL1566084 | 102861 | 2 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 364 | 4 | 1 | 4 | 4.2 | COc1ccc(NS(=O)(=O)c2ccc3ccccc3c2)c2ncccc12 | nan | ||
| 2645512 | 66085 | 3 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 455 | 6 | 0 | 6 | 3.3 | O=C(COC(=O)c1ccc(Br)o1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 | nan | ||
| CHEMBL1411597 | 66085 | 3 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 455 | 6 | 0 | 6 | 3.3 | O=C(COC(=O)c1ccc(Br)o1)c1ccc(S(=O)(=O)N2CCCCC2)cc1 | nan | ||
| 2171031 | 82623 | 8 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 356 | 8 | 1 | 6 | 1.7 | O=C(Cc1ccccc1)NCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1469682 | 82623 | 8 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 356 | 8 | 1 | 6 | 1.7 | O=C(Cc1ccccc1)NCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 889369 | 117333 | 5 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 315 | 3 | 3 | 4 | 3.0 | CC(C)c1ccc(O)c(NC(=S)NC(=O)c2cccnc2)c1 | nan | ||
| CHEMBL1609718 | 117333 | 5 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 315 | 3 | 3 | 4 | 3.0 | CC(C)c1ccc(O)c(NC(=S)NC(=O)c2cccnc2)c1 | nan | ||
| 2905495 | 43870 | 12 | None | 1 | 3 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 400 | 4 | 1 | 9 | 3.3 | Cc1c(Nc2cc(Cl)c3nonc3c2[N+](=O)[O-])c(=O)n(-c2ccccc2)n1C | nan | ||
| CHEMBL1303426 | 43870 | 12 | None | 1 | 3 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 400 | 4 | 1 | 9 | 3.3 | Cc1c(Nc2cc(Cl)c3nonc3c2[N+](=O)[O-])c(=O)n(-c2ccccc2)n1C | nan | ||
| 3239204 | 116872 | 8 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 319 | 4 | 1 | 7 | 4.0 | COc1cccc2sc(Nc3nc(C)c(C(C)=O)s3)nc12 | nan | ||
| CHEMBL1605977 | 116872 | 8 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 319 | 4 | 1 | 7 | 4.0 | COc1cccc2sc(Nc3nc(C)c(C(C)=O)s3)nc12 | nan | ||
| 2848041 | 45915 | 3 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 298 | 3 | 1 | 3 | 3.3 | Cc1ccc2cccc(NS(=O)(=O)c3ccccc3)c2n1 | nan | ||
| CHEMBL1321754 | 45915 | 3 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 298 | 3 | 1 | 3 | 3.3 | Cc1ccc2cccc(NS(=O)(=O)c3ccccc3)c2n1 | nan | ||
| 1472220 | 85316 | 9 | None | 4 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 418 | 6 | 1 | 4 | 4.3 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(Cl)cc2)cn1 | nan | ||
| CHEMBL1494120 | 85316 | 9 | None | 4 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 418 | 6 | 1 | 4 | 4.3 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccc(Cl)cc2)cn1 | nan | ||
| 135636104 | 97366 | 7 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 217 | 3 | 1 | 5 | 2.7 | O=[N+]([O-])c1ccc(N=Nc2ncc[nH]2)cc1 | nan | ||
| CHEMBL1514691 | 97366 | 7 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 217 | 3 | 1 | 5 | 2.7 | O=[N+]([O-])c1ccc(N=Nc2ncc[nH]2)cc1 | nan | ||
| 936147 | 105888 | 6 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 306 | 6 | 0 | 4 | 4.3 | CCCN(CCC)c1nc(-c2ccccn2)nc2ccccc12 | nan | ||
| CHEMBL1593888 | 105888 | 6 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 306 | 6 | 0 | 4 | 4.3 | CCCN(CCC)c1nc(-c2ccccn2)nc2ccccc12 | nan | ||
| 8480343 | 97211 | 3 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 330 | 4 | 2 | 5 | 2.2 | Cc1cc(C)nc(NNS(=O)(=O)c2ccc(F)c(Cl)c2)n1 | nan | ||
| CHEMBL1512236 | 97211 | 3 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 330 | 4 | 2 | 5 | 2.2 | Cc1cc(C)nc(NNS(=O)(=O)c2ccc(F)c(Cl)c2)n1 | nan | ||
| 2632794 | 46590 | 2 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 312 | 5 | 0 | 4 | 3.5 | O=C(Cc1ccc(F)cc1)OCC(=O)c1cc2ccccc2o1 | nan | ||
| CHEMBL1327815 | 46590 | 2 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 312 | 5 | 0 | 4 | 3.5 | O=C(Cc1ccc(F)cc1)OCC(=O)c1cc2ccccc2o1 | nan | ||
| 14956786 | 216620 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 433 | 9 | 2 | 8 | 2.8 | CCCCc1nn(C(C)CO)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL315012 | 216620 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 433 | 9 | 2 | 8 | 2.8 | CCCCc1nn(C(C)CO)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 1610 | 7967 | 67 | None | -1 | 8 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.6019/CHEMBL5442687 | ||
| 3941 | 7967 | 67 | None | -1 | 8 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.6019/CHEMBL5442687 | ||
| 3961 | 7967 | 67 | None | -1 | 8 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.6019/CHEMBL5442687 | ||
| CHEMBL191 | 7967 | 67 | None | -1 | 8 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.6019/CHEMBL5442687 | ||
| 10250898 | 237286 | 0 | None | 37 | 2 | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 408 | 4 | 0 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2)c1 | 10.1021/jm00078a013 | ||
| CHEMBL341407 | 237286 | 0 | None | 37 | 2 | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 408 | 4 | 0 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2)c1 | 10.1021/jm00078a013 | ||
| 6908540 | 217378 | 20 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 305 | 5 | 1 | 5 | 1.9 | O=[N+]([O-])c1cccc(/C=N/NS(=O)(=O)c2ccccc2)c1 | nan | ||
| CHEMBL3191392 | 217378 | 20 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 305 | 5 | 1 | 5 | 1.9 | O=[N+]([O-])c1cccc(/C=N/NS(=O)(=O)c2ccccc2)c1 | nan | ||
| 2739277 | 63345 | 2 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 364 | 4 | 2 | 5 | 4.3 | O=C(NNc1ccc(-c2csnn2)cc1)c1cc(Cl)cc(Cl)c1 | nan | ||
| CHEMBL1386393 | 63345 | 2 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 364 | 4 | 2 | 5 | 4.3 | O=C(NNc1ccc(-c2csnn2)cc1)c1cc(Cl)cc(Cl)c1 | nan | ||
| 135478724 | 78613 | 27 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 240 | 1 | 1 | 2 | 2.9 | O=C1Nc2ccccc2C1=Nc1ccc(F)cc1 | nan | ||
| CHEMBL1434292 | 78613 | 27 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 240 | 1 | 1 | 2 | 2.9 | O=C1Nc2ccccc2C1=Nc1ccc(F)cc1 | nan | ||
| 3118020 | 100752 | 10 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 400 | 6 | 0 | 7 | 1.7 | CC(C(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)N1C(=O)C2C3CCC(C3)C2C1=O | nan | ||
| CHEMBL1545561 | 100752 | 10 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 400 | 6 | 0 | 7 | 1.7 | CC(C(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)N1C(=O)C2C3CCC(C3)C2C1=O | nan | ||
| 164613537 | 368426 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 464 | 8 | 1 | 5 | 5.4 | CCCCC1=NC(C)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4856425 | 368426 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 464 | 8 | 1 | 5 | 5.4 | CCCCC1=NC(C)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 10025873 | 234472 | 0 | None | None | None | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 433 | 4 | 0 | 6 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C#N)c1 | 10.1021/jm00078a013 | ||
| CHEMBL335323 | 234472 | 0 | None | None | None | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 433 | 4 | 0 | 6 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2C#N)c1 | 10.1021/jm00078a013 | ||
| 14956765 | 473389 | 0 | None | None | None | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 469 | 6 | 1 | 7 | 4.5 | O=c1n(-c2ccccc2Cl)nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87890 | 473389 | 0 | None | None | None | Rabbit | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 469 | 6 | 1 | 7 | 4.5 | O=c1n(-c2ccccc2Cl)nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 773605 | 98462 | 27 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 253 | 2 | 2 | 3 | 3.3 | Fc1ccc(NC(S)=Nc2nccs2)cc1 | nan | ||
| CHEMBL1525546 | 98462 | 27 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 253 | 2 | 2 | 3 | 3.3 | Fc1ccc(NC(S)=Nc2nccs2)cc1 | nan | ||
| 3754656 | 101192 | 6 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 362 | 8 | 1 | 6 | 2.6 | O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)NC1CCCCC1 | nan | ||
| CHEMBL1549587 | 101192 | 6 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 362 | 8 | 1 | 6 | 2.6 | O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)NC1CCCCC1 | nan | ||
| 933895 | 46547 | 27 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 166 | 2 | 2 | 5 | 1.0 | CC(C)c1nc(C#N)c(NN)o1 | nan | ||
| CHEMBL1327546 | 46547 | 27 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 166 | 2 | 2 | 5 | 1.0 | CC(C)c1nc(C#N)c(NN)o1 | nan | ||
| 42600949 | 117235 | 0 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 385 | 4 | 1 | 5 | 3.9 | CCC1Nc2ncnc(N3CCCCC3)c2N(Cc2ccc(Cl)cc2)C1=O | nan | ||
| CHEMBL1608922 | 117235 | 0 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 385 | 4 | 1 | 5 | 3.9 | CCC1Nc2ncnc(N3CCCCC3)c2N(Cc2ccc(Cl)cc2)C1=O | nan | ||
| 2811327 | 77816 | 2 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 288 | 4 | 2 | 2 | 4.0 | CCc1ccc(C(=O)NNc2ccc(C)c(Cl)c2)cc1 | nan | ||
| CHEMBL1427235 | 77816 | 2 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 288 | 4 | 2 | 2 | 4.0 | CCc1ccc(C(=O)NNc2ccc(C)c(Cl)c2)cc1 | nan | ||
| 2896074 | 98939 | 8 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 491 | 3 | 2 | 7 | 5.2 | O=C1Nc2ccc(F)cc2C12Nc1ccccc1-c1nnc(SCc3ccccc3Cl)nc1O2 | nan | ||
| CHEMBL1529705 | 98939 | 8 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 491 | 3 | 2 | 7 | 5.2 | O=C1Nc2ccc(F)cc2C12Nc1ccccc1-c1nnc(SCc3ccccc3Cl)nc1O2 | nan | ||
| 2813088 | 101796 | 2 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 290 | 3 | 2 | 5 | 2.9 | Cc1nnsc1C(=O)NNc1ccc(C(C)(C)C)cc1 | nan | ||
| CHEMBL1556712 | 101796 | 2 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 290 | 3 | 2 | 5 | 2.9 | Cc1nnsc1C(=O)NNc1ccc(C(C)(C)C)cc1 | nan | ||
| 6887818 | 217755 | 5 | None | 1 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 430 | 4 | 1 | 4 | 4.8 | O=C(N/N=C/c1ccccn1)c1cc(-c2ccc(Br)cc2)nc2ccccc12 | nan | ||
| CHEMBL3195898 | 217755 | 5 | None | 1 | 2 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 430 | 4 | 1 | 4 | 4.8 | O=C(N/N=C/c1ccccn1)c1cc(-c2ccc(Br)cc2)nc2ccccc12 | nan | ||
| 2883150 | 104183 | 13 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 413 | 9 | 2 | 7 | 2.7 | CC(=O)Nc1ccc(NC(=O)CCC(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)cc1 | nan | ||
| CHEMBL1577988 | 104183 | 13 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 413 | 9 | 2 | 7 | 2.7 | CC(=O)Nc1ccc(NC(=O)CCC(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)cc1 | nan | ||
| 14956788 | 216682 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 447 | 9 | 2 | 8 | 2.9 | CCCCc1nn(C(C)C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL315469 | 216682 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 447 | 9 | 2 | 8 | 2.9 | CCCCc1nn(C(C)C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 2321121 | 118281 | 0 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 557 | 7 | 1 | 5 | 6.3 | O=C(C[n+]1ccc(-c2cc(C(=O)Nc3cccc(C(F)(F)F)c3)c3ccccc3n2)cc1)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1619819 | 118281 | 0 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 557 | 7 | 1 | 5 | 6.3 | O=C(C[n+]1ccc(-c2cc(C(=O)Nc3cccc(C(F)(F)F)c3)c3ccccc3n2)cc1)c1cccc([N+](=O)[O-])c1 | nan | ||
| 2378336 | 79593 | 1 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 271 | 6 | 2 | 4 | 2.5 | COc1ccc(C(=O)CNc2ccccc2CO)cc1 | nan | ||
| CHEMBL1444275 | 79593 | 1 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 271 | 6 | 2 | 4 | 2.5 | COc1ccc(C(=O)CNc2ccccc2CO)cc1 | nan | ||
| 3118009 | 97931 | 8 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 386 | 6 | 0 | 7 | 1.4 | O=C(CN1C(=O)C2C3CCC(C3)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1520643 | 97931 | 8 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 386 | 6 | 0 | 7 | 1.4 | O=C(CN1C(=O)C2C3CCC(C3)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 135492609 | 217869 | 2 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 521 | 2 | 1 | 7 | 3.6 | CN1/C(=c2/s/c(=C3/C(=O)N(c4ccccc4)N=C3Nc3ccccc3)n(C)c2=O)C(C)(C)c2ccccc21 | nan | ||
| CHEMBL3197135 | 217869 | 2 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 521 | 2 | 1 | 7 | 3.6 | CN1/C(=c2/s/c(=C3/C(=O)N(c4ccccc4)N=C3Nc3ccccc3)n(C)c2=O)C(C)(C)c2ccccc21 | nan | ||
| 183134 | 7963 | 16 | None | -134 | 6 | Bovine | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1016/S0960-894X(00)80366-2 | ||
| 3939 | 7963 | 16 | None | -134 | 6 | Bovine | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1016/S0960-894X(00)80366-2 | ||
| CHEMBL7550 | 7963 | 16 | None | -134 | 6 | Bovine | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1016/S0960-894X(00)80366-2 | ||
| 11527144 | 346775 | 0 | None | None | None | Bovine | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL47177 | 346775 | 0 | None | None | None | Bovine | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 14956749 | 473203 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.8 | CCCCc1nn(-c2ccc(CC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86613 | 473203 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.8 | CCCCc1nn(-c2ccc(CC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956803 | 473264 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nn(Cc2ccc3ccccc3c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86986 | 473264 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nn(Cc2ccc3ccccc3c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956767 | 473354 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 483 | 7 | 1 | 7 | 4.5 | O=c1n(-c2ccccc2Cl)nc(CC2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87650 | 473354 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 483 | 7 | 1 | 7 | 4.5 | O=c1n(-c2ccccc2Cl)nc(CC2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 54500223 | 143104 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 444 | 8 | 2 | 7 | 3.0 | CCCc1nc(C)c(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951124 | 143104 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 444 | 8 | 2 | 7 | 3.0 | CCCc1nc(C)c(CC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 324450 | 84342 | 23 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 219 | 3 | 2 | 3 | 1.4 | O=C(CCl)NNc1cccc(Cl)n1 | nan | ||
| CHEMBL1486528 | 84342 | 23 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 219 | 3 | 2 | 3 | 1.4 | O=C(CCl)NNc1cccc(Cl)n1 | nan | ||
| 3103390 | 98125 | 8 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 410 | 7 | 1 | 7 | 2.1 | O=C(CNC(=O)c1ccc(Br)o1)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1522230 | 98125 | 8 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 410 | 7 | 1 | 7 | 2.1 | O=C(CNC(=O)c1ccc(Br)o1)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 1231596 | 79322 | 11 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 406 | 4 | 1 | 7 | 4.2 | COc1cc(/C=C2\SC(=O)N(c3cccc(Cl)c3)C2=O)cc([N+](=O)[O-])c1O | nan | ||
| CHEMBL1441794 | 79322 | 11 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 406 | 4 | 1 | 7 | 4.2 | COc1cc(/C=C2\SC(=O)N(c3cccc(Cl)c3)C2=O)cc([N+](=O)[O-])c1O | nan | ||
| 9653430 | 143974 | 2 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 331 | 3 | 2 | 3 | 4.2 | COc1cccc(NC(=S)N/N=C2\CC3CCC2(C)C3(C)C)c1 | nan | ||
| CHEMBL1966283 | 143974 | 2 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 331 | 3 | 2 | 3 | 4.2 | COc1cccc(NC(=S)N/N=C2\CC3CCC2(C)C3(C)C)c1 | nan | ||
| 161167 | 195858 | 32 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 284 | 3 | 1 | 3 | 3.0 | O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 | nan | ||
| CHEMBL257286 | 195858 | 32 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 284 | 3 | 1 | 3 | 3.0 | O=S(=O)(Nc1cccc2cccnc12)c1ccccc1 | nan | ||
| 3235730 | 105371 | 10 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 432 | 8 | 1 | 9 | 3.4 | CCSC1(SCC)N=C(N)C2(C#N)C(c3ccc(OC)c(OC)c3OC)C12C#N | nan | ||
| CHEMBL1587831 | 105371 | 10 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 432 | 8 | 1 | 9 | 3.4 | CCSC1(SCC)N=C(N)C2(C#N)C(c3ccc(OC)c(OC)c3OC)C12C#N | nan | ||
| 793994 | 61211 | 5 | None | -3 | 4 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 304 | 2 | 1 | 4 | 4.9 | Oc1c(C=Nc2cccc3cccnc23)sc2ccccc12 | nan | ||
| CHEMBL1369123 | 61211 | 5 | None | -3 | 4 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 304 | 2 | 1 | 4 | 4.9 | Oc1c(C=Nc2cccc3cccnc23)sc2ccccc12 | nan | ||
| CHEMBL3190827 | 61211 | 5 | None | -3 | 4 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 304 | 2 | 1 | 4 | 4.9 | Oc1c(C=Nc2cccc3cccnc23)sc2ccccc12 | nan | ||
| 135444079 | 82593 | 11 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 270 | 1 | 1 | 2 | 3.7 | Cc1cccc2c1NC(=O)C2=Nc1ccc(Cl)cc1 | nan | ||
| CHEMBL1469448 | 82593 | 11 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 270 | 1 | 1 | 2 | 3.7 | Cc1cccc2c1NC(=O)C2=Nc1ccc(Cl)cc1 | nan | ||
| 2412176 | 117749 | 4 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 259 | 5 | 1 | 3 | 3.1 | COc1ccc(C(=O)CNc2cccc(F)c2)cc1 | nan | ||
| CHEMBL1613520 | 117749 | 4 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 259 | 5 | 1 | 3 | 3.1 | COc1ccc(C(=O)CNc2cccc(F)c2)cc1 | nan | ||
| 10411101 | 330537 | 0 | None | 676 | 2 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 442 | 7 | 2 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2C)c(C)c1 | 10.1021/jm00078a014 | ||
| CHEMBL424465 | 330537 | 0 | None | 676 | 2 | Rabbit | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 442 | 7 | 2 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2ccccc2C)c(C)c1 | 10.1021/jm00078a014 | ||
| 10371403 | 139210 | 20 | None | None | None | Rabbit | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 601 | 13 | 1 | 10 | 5.8 | CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N+](=O)[O-])c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm049681p | ||
| CHEMBL186572 | 139210 | 20 | None | None | None | Rabbit | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 601 | 13 | 1 | 10 | 5.8 | CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N+](=O)[O-])c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm049681p | ||
| 3119388 | 100602 | 9 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 556 | 7 | 0 | 7 | 2.5 | O=C(CCN1C(=O)C2C3CC(C(Br)C3Br)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1544373 | 100602 | 9 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 556 | 7 | 0 | 7 | 2.5 | O=C(CCN1C(=O)C2C3CC(C(Br)C3Br)C2C1=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 4691872 | 100524 | 1 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 372 | 5 | 1 | 6 | 2.8 | COC(=O)C1NN=C(C(=O)c2ccc(Cl)cc2)C1c1ccc(OC)cc1 | nan | ||
| CHEMBL1543866 | 100524 | 1 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 372 | 5 | 1 | 6 | 2.8 | COC(=O)C1NN=C(C(=O)c2ccc(Cl)cc2)C1c1ccc(OC)cc1 | nan | ||
| 135557876 | 217868 | 2 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 326 | 4 | 3 | 6 | 2.4 | Cc1ncc(CO)c(/C=N/Nc2ccc(C(F)(F)F)cn2)c1O | nan | ||
| CHEMBL3197126 | 217868 | 2 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 326 | 4 | 3 | 6 | 2.4 | Cc1ncc(CO)c(/C=N/Nc2ccc(C(F)(F)F)cn2)c1O | nan | ||
| 2767330 | 196720 | 22 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 272 | 1 | 0 | 3 | 3.7 | Cc1ccc(-c2cc3c(nn2)-c2ccccc2C3=O)cc1 | nan | ||
| CHEMBL261693 | 196720 | 22 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 272 | 1 | 0 | 3 | 3.7 | Cc1ccc(-c2cc3c(nn2)-c2ccccc2C3=O)cc1 | nan | ||
| 852940 | 103081 | 10 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 257 | 2 | 1 | 5 | 3.0 | CCc1cc2c(O)nc(-c3ccccn3)nc2s1 | nan | ||
| CHEMBL1567827 | 103081 | 10 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 257 | 2 | 1 | 5 | 3.0 | CCc1cc2c(O)nc(-c3ccccn3)nc2s1 | nan | ||
| 3138587 | 78011 | 1 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 391 | 6 | 5 | 10 | -2.3 | CN(C)c1ccc2nc3c(=O)[nH]c(=O)nc-3n(CC(O)C(O)C(O)CO)c2c1 | nan | ||
| CHEMBL1428985 | 78011 | 1 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 391 | 6 | 5 | 10 | -2.3 | CN(C)c1ccc2nc3c(=O)[nH]c(=O)nc-3n(CC(O)C(O)C(O)CO)c2c1 | nan | ||
| 1472222 | 62349 | 9 | None | 2 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 414 | 7 | 1 | 5 | 3.6 | COc1ccc(C[S+]([O-])/C(Cl)=C(/Cl)C(=O)Nc2ccc(OC)nc2)cc1 | nan | ||
| CHEMBL1377737 | 62349 | 9 | None | 2 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 414 | 7 | 1 | 5 | 3.6 | COc1ccc(C[S+]([O-])/C(Cl)=C(/Cl)C(=O)Nc2ccc(OC)nc2)cc1 | nan | ||
| 135443160 | 65344 | 4 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 435 | 2 | 1 | 5 | 4.5 | O=C1Nc2ccc(Br)cc2C1=Nc1ccc(-c2nnc3n2CCCCC3)cc1 | nan | ||
| CHEMBL1405610 | 65344 | 4 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 435 | 2 | 1 | 5 | 4.5 | O=C1Nc2ccc(Br)cc2C1=Nc1ccc(-c2nnc3n2CCCCC3)cc1 | nan | ||
| 2920316 | 81129 | 7 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 446 | 9 | 1 | 6 | 3.6 | Cc1ccc(C(=O)COC(=O)CNC(=O)C(c2ccccc2)c2ccccc2)cc1[N+](=O)[O-] | nan | ||
| CHEMBL1457414 | 81129 | 7 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 446 | 9 | 1 | 6 | 3.6 | Cc1ccc(C(=O)COC(=O)CNC(=O)C(c2ccccc2)c2ccccc2)cc1[N+](=O)[O-] | nan | ||
| 4146306 | 58911 | 1 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 347 | 2 | 1 | 4 | 3.3 | O=c1c2cc(Br)ccc2[nH]c(=S)n1Cc1ccccn1 | nan | ||
| CHEMBL1348215 | 58911 | 1 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 347 | 2 | 1 | 4 | 3.3 | O=c1c2cc(Br)ccc2[nH]c(=S)n1Cc1ccccn1 | nan | ||
| 1610 | 7967 | 67 | None | -2 | 8 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80348-6 | ||
| 3941 | 7967 | 67 | None | -2 | 8 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80348-6 | ||
| 3961 | 7967 | 67 | None | -2 | 8 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL191 | 7967 | 67 | None | -2 | 8 | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80348-6 | ||
| 20081616 | 183049 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 500 | 6 | 2 | 8 | 5.3 | Cc1cc(O)nnc1-c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL24266 | 183049 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 500 | 6 | 2 | 8 | 5.3 | Cc1cc(O)nnc1-c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| 44459656 | 199820 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 3.9 | CCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL284140 | 199820 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 3.9 | CCc1nc2ccc(C3=NN(CC(=O)N(C)C)C(=O)CC3)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | ||
| 14956814 | 470609 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 493 | 10 | 1 | 7 | 4.8 | CC(C)CCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL83194 | 470609 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 493 | 10 | 1 | 7 | 4.8 | CC(C)CCc1nn(CCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14971703 | 216734 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2cc(Cl)ccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL315878 | 216734 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 546 | 9 | 2 | 6 | 6.7 | CCCCc1nn(-c2cc(Cl)ccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956761 | 215656 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 494 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313025 | 215656 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 494 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956778 | 473271 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 431 | 9 | 1 | 7 | 3.9 | CCCCc1nn(CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87057 | 473271 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 431 | 9 | 1 | 7 | 3.9 | CCCCc1nn(CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 44320509 | 473311 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 465 | 6 | 2 | 6 | 5.5 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 | 10.1021/jm0603163 | ||
| CHEMBL87327 | 473311 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 465 | 6 | 2 | 6 | 5.5 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)c(N)nc3ccccc23)cc1 | 10.1021/jm0603163 | ||
| 22942224 | 143117 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 583 | 11 | 1 | 9 | 3.9 | CCCCc1nc(C)c(CCC(=O)N2CCC[C@H]2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951137 | 143117 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 583 | 11 | 1 | 9 | 3.9 | CCCCc1nc(C)c(CCC(=O)N2CCC[C@H]2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 44292471 | 313449 | 0 | None | None | None | Bovine | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 563 | 10 | 3 | 8 | 5.0 | CCCCc1nc2ccc(C(C)(O)C[C@H]3CCCN3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | ||
| CHEMBL408033 | 313449 | 0 | None | None | None | Bovine | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 563 | 10 | 3 | 8 | 5.0 | CCCCc1nc2ccc(C(C)(O)C[C@H]3CCCN3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | ||
| 54277224 | 143113 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 540 | 9 | 1 | 8 | 3.1 | CCCCc1nc(C)c(CC(=O)N2CCN(C)CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951133 | 143113 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 540 | 9 | 1 | 8 | 3.1 | CCCCc1nc(C)c(CC(=O)N2CCN(C)CC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14971718 | 39425 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 388 | 7 | 3 | 5 | 3.5 | CCCc1n[nH]c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL121847 | 39425 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 388 | 7 | 3 | 5 | 3.5 | CCCc1n[nH]c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956753 | 216718 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 527 | 9 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL315776 | 216718 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 527 | 9 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14971721 | 222639 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 544 | 8 | 2 | 6 | 6.3 | O=C(O)c1c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CC2CC2)nn1-c1c(Cl)cccc1Cl | 10.1021/jm00075a014 | ||
| CHEMBL331475 | 222639 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 544 | 8 | 2 | 6 | 6.3 | O=C(O)c1c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CC2CC2)nn1-c1c(Cl)cccc1Cl | 10.1021/jm00075a014 | ||
| 4673492 | 8951 | 9 | None | -6 | 2 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1021/jm9504722 | ||
| 8324 | 8951 | 9 | None | -6 | 2 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1021/jm9504722 | ||
| CHEMBL159096 | 8951 | 9 | None | -6 | 2 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1021/jm9504722 | ||
| 14971689 | 26479 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 512 | 10 | 1 | 7 | 5.4 | CCCCc1nn(CC(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL118431 | 26479 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 512 | 10 | 1 | 7 | 5.4 | CCCCc1nn(CC(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 44211605 | 335305 | 0 | None | None | None | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 577 | 10 | 1 | 10 | 5.0 | CCCCc1nc2ccc(C3CC(C(=O)OCC)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL44526 | 335305 | 0 | None | None | None | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 577 | 10 | 1 | 10 | 5.0 | CCCCc1nc2ccc(C3CC(C(=O)OCC)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 14956809 | 215871 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 656 | 15 | 1 | 9 | 6.5 | CCCCc1nn(CCCN(Cc2ccccc2)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313837 | 215871 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 656 | 15 | 1 | 9 | 6.5 | CCCCc1nn(CCCN(Cc2ccccc2)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 132562 | 199875 | 5 | None | None | None | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm9504722 | ||
| CHEMBL284536 | 199875 | 5 | None | None | None | Guinea pig | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm9504722 | ||
| 57403666 | 143102 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 472 | 9 | 1 | 8 | 3.5 | CCOC(=O)CCc1c(C)nc(CC)n(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c1=O | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951122 | 143102 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 472 | 9 | 1 | 8 | 3.5 | CCOC(=O)CCc1c(C)nc(CC)n(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c1=O | 10.1016/j.bmcl.2011.12.116 | ||
| 57396698 | 143107 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 513 | 11 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=O)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951127 | 143107 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 513 | 11 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=O)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 6918269 | 198737 | 11 | None | -5 | 2 | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL275875 | 198737 | 11 | None | -5 | 2 | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 10027636 | 58290 | 0 | None | 70 | 2 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 468 | 9 | 1 | 5 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL134286 | 58290 | 0 | None | 70 | 2 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 468 | 9 | 1 | 5 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC2CC2)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| 135406019 | 57730 | 9 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 264 | 2 | 1 | 3 | 3.0 | CC(=O)c1ccc(N=C2C(=O)Nc3ccccc32)cc1 | nan | ||
| CHEMBL1338100 | 57730 | 9 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 264 | 2 | 1 | 3 | 3.0 | CC(=O)c1ccc(N=C2C(=O)Nc3ccccc32)cc1 | nan | ||
| 3395163 | 63490 | 3 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 441 | 11 | 1 | 7 | 3.5 | CSCCC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1 | nan | ||
| CHEMBL1387520 | 63490 | 3 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 441 | 11 | 1 | 7 | 3.5 | CSCCC(NC(=O)COc1ccccc1)C(=O)OCC(=O)c1cc2ccccc2o1 | nan | ||
| 6603703 | 427 | 11 | None | -2 | 12 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 329 | 2 | 3 | 4 | 3.3 | NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3 | 10.6019/CHEMBL5442687 | ||
| 9637 | 427 | 11 | None | -2 | 12 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 329 | 2 | 3 | 4 | 3.3 | NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3 | 10.6019/CHEMBL5442687 | ||
| CHEMBL291143 | 427 | 11 | None | -2 | 12 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 329 | 2 | 3 | 4 | 3.3 | NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3 | 10.6019/CHEMBL5442687 | ||
| 16012865 | 47166 | 7 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 480 | 6 | 1 | 7 | 2.6 | CN(c1ccccc1)S(=O)(=O)c1ccc(NC(=O)c2nc(S(C)(=O)=O)ncc2Cl)cc1 | nan | ||
| CHEMBL1332454 | 47166 | 7 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 480 | 6 | 1 | 7 | 2.6 | CN(c1ccccc1)S(=O)(=O)c1ccc(NC(=O)c2nc(S(C)(=O)=O)ncc2Cl)cc1 | nan | ||
| 67903275 | 369789 | 8 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 402 | 7 | 1 | 5 | 4.2 | CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4877651 | 369789 | 8 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 402 | 7 | 1 | 5 | 4.2 | CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 142534170 | 331616 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 591 | 9 | 1 | 7 | 5.8 | CCCCc1nc(C)c(CC(=S)N2Cc3ccccc3C2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4284403 | 331616 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 591 | 9 | 1 | 7 | 5.8 | CCCCc1nc(C)c(CC(=S)N2Cc3ccccc3C2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 44292039 | 355925 | 1 | None | None | None | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 547 | 8 | 1 | 8 | 5.5 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL47817 | 355925 | 1 | None | None | None | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 547 | 8 | 1 | 8 | 5.5 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 14956801 | 470896 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 555 | 9 | 1 | 7 | 5.0 | CCCCc1nn(Cc2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85765 | 470896 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 555 | 9 | 1 | 7 | 5.0 | CCCCc1nn(Cc2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10251520 | 199062 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 419 | 5 | 0 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C#N)c1 | 10.1021/jm00078a013 | ||
| CHEMBL278656 | 199062 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 419 | 5 | 0 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C#N)c1 | 10.1021/jm00078a013 | ||
| 5731496 | 106396 | 7 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 281 | 2 | 1 | 2 | 4.8 | Oc1cccc2ccc(/C=C/c3ccccc3Cl)nc12 | nan | ||
| CHEMBL1598569 | 106396 | 7 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 281 | 2 | 1 | 2 | 4.8 | Oc1cccc2ccc(/C=C/c3ccccc3Cl)nc12 | nan | ||
| 1613606 | 101283 | 11 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 392 | 8 | 1 | 7 | 1.6 | Cc1ccc(C(=O)COC(=O)CNS(=O)(=O)c2ccccc2)cc1[N+](=O)[O-] | nan | ||
| CHEMBL1550301 | 101283 | 11 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 392 | 8 | 1 | 7 | 1.6 | Cc1ccc(C(=O)COC(=O)CNS(=O)(=O)c2ccccc2)cc1[N+](=O)[O-] | nan | ||
| 44417426 | 278790 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 469 | 6 | 2 | 5 | 5.1 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(C2c3ccccc3C(C)(O)C2C(=O)O)cc1 | 10.1021/jm0603163 | ||
| CHEMBL384936 | 278790 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 469 | 6 | 2 | 5 | 5.1 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(C2c3ccccc3C(C)(O)C2C(=O)O)cc1 | 10.1021/jm0603163 | ||
| 14956751 | 473278 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87073 | 473278 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956802 | 473291 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nn(Cc2cccc3ccccc23)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87184 | 473291 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 515 | 9 | 1 | 7 | 5.5 | CCCCc1nn(Cc2cccc3ccccc23)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 1610 | 7967 | 67 | None | -19 | 8 | Bovine | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80365-0 | ||
| 3941 | 7967 | 67 | None | -19 | 8 | Bovine | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80365-0 | ||
| 3961 | 7967 | 67 | None | -19 | 8 | Bovine | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL191 | 7967 | 67 | None | -19 | 8 | Bovine | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80365-0 | ||
| 44355656 | 235014 | 0 | None | None | None | Rabbit | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 467 | 6 | 1 | 6 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2NC(=O)OC)c1 | 10.1021/jm00078a013 | ||
| CHEMBL335680 | 235014 | 0 | None | None | None | Rabbit | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 467 | 6 | 1 | 6 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2NC(=O)OC)c1 | 10.1021/jm00078a013 | ||
| 44202070 | 83059 | 0 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 271 | 1 | 0 | 2 | 3.5 | Cc1ccc2c(c1)C(=O)C(=O)N2c1ccc(Cl)cc1 | nan | ||
| CHEMBL1474191 | 83059 | 0 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 271 | 1 | 0 | 2 | 3.5 | Cc1ccc2c(c1)C(=O)C(=O)N2c1ccc(Cl)cc1 | nan | ||
| 1730709 | 57737 | 9 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 370 | 8 | 1 | 6 | 3.0 | Cc1ccccc1NC(=O)CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1338165 | 57737 | 9 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 370 | 8 | 1 | 6 | 3.0 | Cc1ccccc1NC(=O)CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 2899190 | 105773 | 8 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 386 | 6 | 0 | 7 | 1.6 | Cc1ccc(C(=O)COC(=O)CN2C(=O)C3CC=CCC3C2=O)cc1[N+](=O)[O-] | nan | ||
| CHEMBL1592181 | 105773 | 8 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 386 | 6 | 0 | 7 | 1.6 | Cc1ccc(C(=O)COC(=O)CN2C(=O)C3CC=CCC3C2=O)cc1[N+](=O)[O-] | nan | ||
| 2285607 | 82011 | 8 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 400 | 9 | 1 | 7 | 3.1 | COc1ccccc1NC(=O)CCC(=O)OCC(=O)c1ccc(C)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1464749 | 82011 | 8 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 400 | 9 | 1 | 7 | 3.1 | COc1ccccc1NC(=O)CCC(=O)OCC(=O)c1ccc(C)c([N+](=O)[O-])c1 | nan | ||
| 44201736 | 61128 | 0 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 586 | 9 | 2 | 5 | 5.2 | O=C1NC[C@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H]1CC(=O)N(CCO)Cc1ccccc1 | nan | ||
| CHEMBL1368499 | 61128 | 0 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 586 | 9 | 2 | 5 | 5.2 | O=C1NC[C@H](c2ccccc2)OC(=O)[C@@H](Cc2ccc(F)cc2)CC/C=C/C[C@@H]1CC(=O)N(CCO)Cc1ccccc1 | nan | ||
| 16195321 | 104278 | 2 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 413 | 6 | 0 | 5 | 4.9 | CN(C)CCN(Cc1ccco1)C(=O)c1cc2c(Cl)nc3ccccc3c2s1 | nan | ||
| CHEMBL1578651 | 104278 | 2 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 413 | 6 | 0 | 5 | 4.9 | CN(C)CCN(Cc1ccco1)C(=O)c1cc2c(Cl)nc3ccccc3c2s1 | nan | ||
| 10344571 | 235520 | 0 | None | 125 | 2 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 468 | 9 | 1 | 5 | 5.8 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| CHEMBL336773 | 235520 | 0 | None | 125 | 2 | Rabbit | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 468 | 9 | 1 | 5 | 5.8 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| 4210369 | 85847 | 11 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 424 | 8 | 1 | 6 | 4.0 | O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)Nc1cccc(Cl)c1Cl | nan | ||
| CHEMBL1499072 | 85847 | 11 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 424 | 8 | 1 | 6 | 4.0 | O=C(CCC(=O)OCC(=O)c1cccc([N+](=O)[O-])c1)Nc1cccc(Cl)c1Cl | nan | ||
| 1726742 | 67011 | 11 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 398 | 9 | 1 | 7 | 2.9 | CC(=O)c1ccc(NC(=O)CCC(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)cc1 | nan | ||
| CHEMBL1419495 | 67011 | 11 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 398 | 9 | 1 | 7 | 2.9 | CC(=O)c1ccc(NC(=O)CCC(=O)OCC(=O)c2cccc([N+](=O)[O-])c2)cc1 | nan | ||
| 6917582 | 98952 | 0 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 378 | 3 | 1 | 5 | 3.1 | COc1ccc2c(c1)C(=O)[C@H](O)[C@@H](c1ccc(OC)c(Br)c1)O2 | nan | ||
| 9548123 | 98952 | 0 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 378 | 3 | 1 | 5 | 3.1 | COc1ccc2c(c1)C(=O)[C@H](O)[C@@H](c1ccc(OC)c(Br)c1)O2 | nan | ||
| CHEMBL1529805 | 98952 | 0 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 378 | 3 | 1 | 5 | 3.1 | COc1ccc2c(c1)C(=O)[C@H](O)[C@@H](c1ccc(OC)c(Br)c1)O2 | nan | ||
| CHEMBL1548173 | 98952 | 0 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 378 | 3 | 1 | 5 | 3.1 | COc1ccc2c(c1)C(=O)[C@H](O)[C@@H](c1ccc(OC)c(Br)c1)O2 | nan | ||
| 5416363 | 217800 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 295 | 3 | 1 | 3 | 3.5 | C/C(=N/NC(=O)c1ccc(C(C)(C)C)cc1)c1ccccn1 | nan | ||
| CHEMBL3196324 | 217800 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 295 | 3 | 1 | 3 | 3.5 | C/C(=N/NC(=O)c1ccc(C(C)(C)C)cc1)c1ccccn1 | nan | ||
| 44292214 | 349866 | 0 | None | None | None | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 577 | 9 | 2 | 9 | 4.6 | CCCCc1nc2ccc([C@]3(CO)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL45864 | 349866 | 0 | None | None | None | Bovine | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 577 | 9 | 2 | 9 | 4.6 | CCCCc1nc2ccc([C@]3(CO)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 10364891 | 59925 | 0 | None | 33 | 2 | Rabbit | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 421 | 5 | 0 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1 | 10.1021/jm00078a013 | ||
| CHEMBL135792 | 59925 | 0 | None | 33 | 2 | Rabbit | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 421 | 5 | 0 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccccc1 | 10.1021/jm00078a013 | ||
| 9550553 | 117368 | 5 | None | 2 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 445 | 8 | 1 | 11 | 4.3 | CCC(=O)OCCNc1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] | nan | ||
| CHEMBL1610025 | 117368 | 5 | None | 2 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 445 | 8 | 1 | 11 | 4.3 | CCC(=O)OCCNc1cc(Sc2nc3ccccc3s2)c2nonc2c1[N+](=O)[O-] | nan | ||
| 1266032 | 84305 | 3 | None | 3 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 343 | 2 | 0 | 3 | 4.9 | O=C(Sc1cccc2cccnc12)c1ccccc1Br | nan | ||
| CHEMBL1486214 | 84305 | 3 | None | 3 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 343 | 2 | 0 | 3 | 4.9 | O=C(Sc1cccc2cccnc12)c1ccccc1Br | nan | ||
| 9608279 | 217419 | 6 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 366 | 6 | 1 | 8 | 3.1 | COc1ccc(/C=N/Nc2cc(C)nc(-n3nc(C)cc3C)n2)c(OC)c1 | nan | ||
| CHEMBL3191846 | 217419 | 6 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 366 | 6 | 1 | 8 | 3.1 | COc1ccc(/C=N/Nc2cc(C)nc(-n3nc(C)cc3C)n2)c(OC)c1 | nan | ||
| 5341487 | 144563 | 23 | None | -1 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 317 | 3 | 1 | 3 | 3.0 | C/C(=N\NC(=O)c1cccc(Br)c1)c1ccccn1 | nan | ||
| CHEMBL1984876 | 144563 | 23 | None | -1 | 2 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 317 | 3 | 1 | 3 | 3.0 | C/C(=N\NC(=O)c1cccc(Br)c1)c1ccccn1 | nan | ||
| 11100 | 253948 | 58 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 192 | 3 | 1 | 4 | 1.8 | O=C(c1ccco1)C(O)c1ccco1 | nan | ||
| CHEMBL364893 | 253948 | 58 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 192 | 3 | 1 | 4 | 1.8 | O=C(c1ccco1)C(O)c1ccco1 | nan | ||
| 135472780 | 62105 | 5 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 277 | 2 | 1 | 4 | 5.0 | Cc1ccc(N=Nc2ccc(O)c3ncccc23)cc1C | nan | ||
| CHEMBL1375373 | 62105 | 5 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 277 | 2 | 1 | 4 | 5.0 | Cc1ccc(N=Nc2ccc(O)c3ncccc23)cc1C | nan | ||
| 2360979 | 82400 | 3 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 275 | 5 | 1 | 3 | 3.6 | COc1ccccc1NCC(=O)c1ccc(Cl)cc1 | nan | ||
| CHEMBL1467838 | 82400 | 3 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 275 | 5 | 1 | 3 | 3.6 | COc1ccccc1NCC(=O)c1ccc(Cl)cc1 | nan | ||
| 3106500 | 58483 | 7 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 306 | 3 | 1 | 7 | 1.5 | CC1=NN(C(N)=S)C(=O)C1N=Nc1ccc([N+](=O)[O-])cc1 | nan | ||
| CHEMBL1344603 | 58483 | 7 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 306 | 3 | 1 | 7 | 1.5 | CC1=NN(C(N)=S)C(=O)C1N=Nc1ccc([N+](=O)[O-])cc1 | nan | ||
| 2431535 | 82373 | 3 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 343 | 4 | 0 | 4 | 4.1 | O=C(COC(=O)c1cccnc1Cl)c1ccc(Cl)cc1Cl | nan | ||
| CHEMBL1467556 | 82373 | 3 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 343 | 4 | 0 | 4 | 4.1 | O=C(COC(=O)c1cccnc1Cl)c1ccc(Cl)cc1Cl | nan | ||
| 2324620 | 58592 | 11 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 455 | 4 | 4 | 4 | 4.3 | CC(C)(C)c1cc(CCC(=O)NNC(=S)NC(=O)c2ccccc2)cc(C(C)(C)C)c1O | nan | ||
| CHEMBL1345564 | 58592 | 11 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 455 | 4 | 4 | 4 | 4.3 | CC(C)(C)c1cc(CCC(=O)NNC(=S)NC(=O)c2ccccc2)cc(C(C)(C)C)c1O | nan | ||
| 1875884 | 58200 | 5 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 436 | 5 | 3 | 6 | 3.0 | COc1ccc(/C=C/C(=O)NC(=S)NNC(=O)c2c(-c3ccccc3)noc2C)cc1 | nan | ||
| CHEMBL1342221 | 58200 | 5 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 436 | 5 | 3 | 6 | 3.0 | COc1ccc(/C=C/C(=O)NC(=S)NNC(=O)c2c(-c3ccccc3)noc2C)cc1 | nan | ||
| 16012896 | 66621 | 8 | None | 1 | 3 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 494 | 7 | 1 | 7 | 3.0 | CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N(C)c3ccccc3)cc2)n1 | nan | ||
| CHEMBL1416089 | 66621 | 8 | None | 1 | 3 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 494 | 7 | 1 | 7 | 3.0 | CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N(C)c3ccccc3)cc2)n1 | nan | ||
| 2352555 | 105599 | 3 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 309 | 4 | 0 | 4 | 3.4 | O=C(OCC(=O)c1ccc(Cl)cc1Cl)c1ccccn1 | nan | ||
| CHEMBL1589900 | 105599 | 3 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Functional | ChEMBL | 309 | 4 | 0 | 4 | 3.4 | O=C(OCC(=O)c1ccc(Cl)cc1Cl)c1ccccn1 | nan | ||
| 3146836 | 217291 | 7 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 399 | 4 | 1 | 6 | 5.6 | CCOC(=O)C1=C(C)N=C2CC(c3cccs3)CC(O)=C2C1c1cccs1 | nan | ||
| CHEMBL3190347 | 217291 | 7 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 399 | 4 | 1 | 6 | 5.6 | CCOC(=O)C1=C(C)N=C2CC(c3cccs3)CC(O)=C2C1c1cccs1 | nan | ||
| 52936725 | 124010 | 25 | None | -758 | 9 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 432 | 6 | 2 | 4 | 6.3 | Cc1cc(C)cc(-c2cnc3cc(Cl)c(-c4cccc(O)c4)cc3c2OCCCN)c1 | 10.6019/CHEMBL5442687 | ||
| CHEMBL1766103 | 124010 | 25 | None | -758 | 9 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 432 | 6 | 2 | 4 | 6.3 | Cc1cc(C)cc(-c2cnc3cc(Cl)c(-c4cccc(O)c4)cc3c2OCCCN)c1 | 10.6019/CHEMBL5442687 | ||
| 135400342 | 83206 | 6 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 293 | 4 | 2 | 7 | 2.2 | O=[N+]([O-])c1ccc(O)c(/C=N/Nc2ccc(Cl)nn2)c1 | nan | ||
| CHEMBL1476264 | 83206 | 6 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 293 | 4 | 2 | 7 | 2.2 | O=[N+]([O-])c1ccc(O)c(/C=N/Nc2ccc(Cl)nn2)c1 | nan | ||
| 1612942 | 84263 | 8 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 370 | 7 | 1 | 6 | 2.4 | Cc1ccc(C(=O)NCC(=O)OCC(=O)c2ccc(C)c([N+](=O)[O-])c2)cc1 | nan | ||
| CHEMBL1485784 | 84263 | 8 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 370 | 7 | 1 | 6 | 2.4 | Cc1ccc(C(=O)NCC(=O)OCC(=O)c2ccc(C)c([N+](=O)[O-])c2)cc1 | nan | ||
| 24818379 | 84524 | 3 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 353 | 6 | 2 | 8 | 1.3 | COc1ccc(S(=O)(=O)NNc2nc(C)cc(C)n2)cc1[N+](=O)[O-] | nan | ||
| CHEMBL1487991 | 84524 | 3 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 353 | 6 | 2 | 8 | 1.3 | COc1ccc(S(=O)(=O)NNc2nc(C)cc(C)n2)cc1[N+](=O)[O-] | nan | ||
| 82533 | 84471 | 48 | None | -6 | 4 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 298 | 3 | 1 | 3 | 3.3 | Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)cc1 | nan | ||
| CHEMBL1487635 | 84471 | 48 | None | -6 | 4 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 298 | 3 | 1 | 3 | 3.3 | Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)cc1 | nan | ||
| 5286934 | 102543 | 5 | None | -2 | 4 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 294 | 9 | 0 | 4 | 2.4 | CCCCS(=O)(=O)/C=C\C=C/S(=O)(=O)CCCC | nan | ||
| CHEMBL1563483 | 102543 | 5 | None | -2 | 4 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 294 | 9 | 0 | 4 | 2.4 | CCCCS(=O)(=O)/C=C\C=C/S(=O)(=O)CCCC | nan | ||
| 930382 | 77501 | 9 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 309 | 4 | 0 | 4 | 3.4 | O=C(COC(=O)c1cccnc1)c1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL1424582 | 77501 | 9 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 309 | 4 | 0 | 4 | 3.4 | O=C(COC(=O)c1cccnc1)c1ccc(Cl)c(Cl)c1 | nan | ||
| 2811457 | 77913 | 2 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 273 | 4 | 2 | 4 | 3.2 | Cc1noc(C)c1C(=O)NNc1ccc(C(C)C)cc1 | nan | ||
| CHEMBL1428121 | 77913 | 2 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 273 | 4 | 2 | 4 | 3.2 | Cc1noc(C)c1C(=O)NNc1ccc(C(C)C)cc1 | nan | ||
| 621 | 6180 | 31 | None | -10471 | 5 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 554 | 9 | 4 | 5 | 5.6 | O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] | 10.6019/CHEMBL5442687 | ||
| 9937534 | 6180 | 31 | None | -10471 | 5 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 554 | 9 | 4 | 5 | 5.6 | O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] | 10.6019/CHEMBL5442687 | ||
| CHEMBL329650 | 6180 | 31 | None | -10471 | 5 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 554 | 9 | 4 | 5 | 5.6 | O=C(N[C@](C(=O)NCC1(CCCCC1)c1ccccn1)(Cc1c[nH]c2c1cccc2)C)Nc1ccc(cc1)[N+](=O)[O-] | 10.6019/CHEMBL5442687 | ||
| 14971679 | 221144 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 608 | 10 | 1 | 7 | 7.8 | CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL328598 | 221144 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 608 | 10 | 1 | 7 | 7.8 | CCCCc1nn(-c2c(Cl)cc(Cl)cc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 108185 | 3317 | 57 | None | -3 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00069a015 | ||
| 586 | 3317 | 57 | None | -3 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00069a015 | ||
| CHEMBL907 | 3317 | 57 | None | -3 | 4 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00069a015 | ||
| 14956783 | 470589 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 414 | 8 | 1 | 8 | 2.8 | CCCCc1nn(CC#N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL82920 | 470589 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 414 | 8 | 1 | 8 | 2.8 | CCCCc1nn(CC#N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 9612783 | 217550 | 2 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 345 | 6 | 1 | 4 | 3.7 | C/C(=N\NC(=O)COc1ccccc1-c1ccccc1)c1ccccn1 | nan | ||
| CHEMBL3193378 | 217550 | 2 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 345 | 6 | 1 | 4 | 3.7 | C/C(=N\NC(=O)COc1ccccc1-c1ccccc1)c1ccccn1 | nan | ||
| 142534004 | 332143 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 557 | 9 | 1 | 7 | 5.3 | CCCCc1nc(C)c(CC(=S)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4294618 | 332143 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 557 | 9 | 1 | 7 | 5.3 | CCCCc1nc(C)c(CC(=S)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 15229102 | 201325 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.9 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL295695 | 201325 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.9 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 9982458 | 60183 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 476 | 8 | 1 | 5 | 6.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2Cl)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL136034 | 60183 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 476 | 8 | 1 | 5 | 6.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2Cl)cc1 | 10.1021/jm00078a014 | ||
| 1720698 | 43389 | 8 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 378 | 8 | 1 | 7 | 1.3 | O=C(CNS(=O)(=O)c1ccccc1)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL1299557 | 43389 | 8 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 378 | 8 | 1 | 7 | 1.3 | O=C(CNS(=O)(=O)c1ccccc1)OCC(=O)c1cccc([N+](=O)[O-])c1 | nan | ||
| 2812498 | 87058 | 2 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 362 | 5 | 2 | 4 | 4.3 | Cc1ccc(NNC(=O)c2cc(C(C)(C)C)nn2Cc2ccccc2)cc1 | nan | ||
| CHEMBL1509694 | 87058 | 2 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 362 | 5 | 2 | 4 | 4.3 | Cc1ccc(NNC(=O)c2cc(C(C)(C)C)nn2Cc2ccccc2)cc1 | nan | ||
| 888488 | 103934 | 9 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 301 | 5 | 0 | 7 | 1.7 | Cc1ccc(C(=O)COC(=O)c2cnccn2)cc1[N+](=O)[O-] | nan | ||
| CHEMBL1575784 | 103934 | 9 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 301 | 5 | 0 | 7 | 1.7 | Cc1ccc(C(=O)COC(=O)c2cnccn2)cc1[N+](=O)[O-] | nan | ||
| 2766929 | 103545 | 21 | None | -20 | 4 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 287 | 1 | 0 | 4 | 3.1 | CC(C)(C)c1ccc(-n2nc(C#N)c(Cl)cc2=O)cc1 | nan | ||
| CHEMBL1572001 | 103545 | 21 | None | -20 | 4 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 287 | 1 | 0 | 4 | 3.1 | CC(C)(C)c1ccc(-n2nc(C#N)c(Cl)cc2=O)cc1 | nan | ||
| 130606 | 79739 | 48 | None | -9 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 328 | 4 | 1 | 4 | 3.4 | COc1cc(NS(=O)(=O)c2ccc(C)cc2)c2ncccc2c1 | nan | ||
| CHEMBL1445650 | 79739 | 48 | None | -9 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 328 | 4 | 1 | 4 | 3.4 | COc1cc(NS(=O)(=O)c2ccc(C)cc2)c2ncccc2c1 | nan | ||
| 44292173 | 336972 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.3 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL44798 | 336972 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.3 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 164616479 | 368610 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 404 | 7 | 2 | 5 | 3.8 | CCCCC1NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL4859498 | 368610 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 404 | 7 | 2 | 5 | 3.8 | CCCCC1NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 2426323 | 81027 | 3 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 360 | 3 | 3 | 3 | 4.6 | Cc1ccccc1N=C(S)NNc1ncc(C(F)(F)F)cc1Cl | nan | ||
| CHEMBL1456428 | 81027 | 3 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 360 | 3 | 3 | 3 | 4.6 | Cc1ccccc1N=C(S)NNc1ncc(C(F)(F)F)cc1Cl | nan | ||
| 1472216 | 103849 | 9 | None | -3 | 3 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 384 | 6 | 1 | 4 | 3.6 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccccc2)cn1 | nan | ||
| CHEMBL1574879 | 103849 | 9 | None | -3 | 3 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 384 | 6 | 1 | 4 | 3.6 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccccc2)cn1 | nan | ||
| 135421501 | 103070 | 10 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 344 | 2 | 1 | 3 | 3.8 | COc1ccc(N=C2C(=O)Nc3ccc(C)c(Br)c32)cc1 | nan | ||
| CHEMBL1567702 | 103070 | 10 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 344 | 2 | 1 | 3 | 3.8 | COc1ccc(N=C2C(=O)Nc3ccc(C)c(Br)c32)cc1 | nan | ||
| 16193016 | 118942 | 4 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 354 | 4 | 0 | 2 | 3.4 | O=C(C[N+]1(CC#Cc2ccccc2)CCOCC1)c1ccc(Cl)cc1 | nan | ||
| CHEMBL1625597 | 118942 | 4 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 354 | 4 | 0 | 2 | 3.4 | O=C(C[N+]1(CC#Cc2ccccc2)CCOCC1)c1ccc(Cl)cc1 | nan | ||
| 3368605 | 43671 | 6 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 504 | 5 | 0 | 6 | 5.4 | O=C(OCC(=O)c1ccc(Cl)cc1Cl)c1ccc2c(c1)C(=O)N(c1cccc3ncccc13)C2=O | nan | ||
| CHEMBL1301939 | 43671 | 6 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 504 | 5 | 0 | 6 | 5.4 | O=C(OCC(=O)c1ccc(Cl)cc1Cl)c1ccc2c(c1)C(=O)N(c1cccc3ncccc13)C2=O | nan | ||
| 2114872 | 44632 | 3 | None | 1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 273 | 2 | 1 | 4 | 3.1 | O=C(Nc1nc2ccc(F)cc2s1)c1ccccn1 | nan | ||
| CHEMBL1309573 | 44632 | 3 | None | 1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 273 | 2 | 1 | 4 | 3.1 | O=C(Nc1nc2ccc(F)cc2s1)c1ccccn1 | nan | ||
| 2928370 | 98747 | 7 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 356 | 5 | 1 | 5 | 3.2 | CCOC(=O)C1=NNC(C(=O)c2ccc(Cl)cc2)C1c1ccccc1 | nan | ||
| CHEMBL1528033 | 98747 | 7 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 356 | 5 | 1 | 5 | 3.2 | CCOC(=O)C1=NNC(C(=O)c2ccc(Cl)cc2)C1c1ccccc1 | nan | ||
| 135426090 | 77838 | 10 | None | 3 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 318 | 3 | 2 | 6 | 4.0 | Cc1ccc2oc(Nc3nc(O)cc(-c4ccccc4)n3)nc2c1 | nan | ||
| CHEMBL1427431 | 77838 | 10 | None | 3 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 318 | 3 | 2 | 6 | 4.0 | Cc1ccc2oc(Nc3nc(O)cc(-c4ccccc4)n3)nc2c1 | nan | ||
| 135632169 | 104901 | 6 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 419 | 5 | 2 | 7 | 2.4 | O=C1N=C(NS(=O)(=O)Cc2ccccc2)S/C1=C/c1cc([N+](=O)[O-])ccc1O | nan | ||
| 136087362 | 104901 | 6 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 419 | 5 | 2 | 7 | 2.4 | O=C1N=C(NS(=O)(=O)Cc2ccccc2)S/C1=C/c1cc([N+](=O)[O-])ccc1O | nan | ||
| CHEMBL1583998 | 104901 | 6 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 419 | 5 | 2 | 7 | 2.4 | O=C1N=C(NS(=O)(=O)Cc2ccccc2)S/C1=C/c1cc([N+](=O)[O-])ccc1O | nan | ||
| 10456041 | 59545 | 0 | None | 186 | 2 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 442 | 8 | 1 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL135346 | 59545 | 0 | None | 186 | 2 | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 442 | 8 | 1 | 5 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| 44459595 | 199658 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 516 | 6 | 2 | 7 | 5.1 | CC1(C)CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL283055 | 199658 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 516 | 6 | 2 | 7 | 5.1 | CC1(C)CC(=O)NN=C1c1ccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)80348-6 | ||
| 44459878 | 199898 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 574 | 8 | 1 | 9 | 4.6 | COC(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)CC1=O | 10.1016/S0960-894X(01)80348-6 | ||
| CHEMBL284704 | 199898 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 574 | 8 | 1 | 9 | 4.6 | COC(=O)CN1N=C(c2ccc3nc(C4CC4)n(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)C(C)CC1=O | 10.1016/S0960-894X(01)80348-6 | ||
| 53657506 | 143118 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 557 | 10 | 1 | 8 | 4.3 | CCCCc1nc(C)c(CCC(=O)N2CCSCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951138 | 143118 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 557 | 10 | 1 | 8 | 4.3 | CCCCc1nc(C)c(CCC(=O)N2CCSCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14956738 | 470607 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL83180 | 470607 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 4906 | 143124 | 59 | None | -15 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 9870652 | 143124 | 59 | None | -15 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL1951143 | 143124 | 59 | None | -15 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| DB09279 | 143124 | 59 | None | -15 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 11974939 | 163566 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 466 | 5 | 1 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)n(C)c(=O)c3ccccc23)cc1 | 10.1021/jm0603163 | ||
| CHEMBL216747 | 163566 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 466 | 5 | 1 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(C(=O)O)n(C)c(=O)c3ccccc23)cc1 | 10.1021/jm0603163 | ||
| 10183373 | 329922 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 465 | 9 | 1 | 7 | 4.3 | CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL422593 | 329922 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 465 | 9 | 1 | 7 | 4.3 | CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10183373 | 329922 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 465 | 9 | 1 | 7 | 4.3 | CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL422593 | 329922 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 465 | 9 | 1 | 7 | 4.3 | CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 54199501 | 143099 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 486 | 10 | 1 | 8 | 3.9 | CCCCc1nc(C)c(CC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951119 | 143099 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 486 | 10 | 1 | 8 | 3.9 | CCCCc1nc(C)c(CC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 54558598 | 143108 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 499 | 10 | 1 | 7 | 3.8 | CCCc1nc(C)c(CC(=O)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951128 | 143108 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 499 | 10 | 1 | 7 | 3.8 | CCCc1nc(C)c(CC(=O)N(CC)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 142534183 | 332060 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 503 | 8 | 1 | 7 | 4.0 | CCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4293170 | 332060 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 503 | 8 | 1 | 7 | 4.0 | CCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 14956794 | 470865 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.9 | CCCCc1nn(C(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85545 | 470865 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 479 | 9 | 1 | 7 | 4.9 | CCCCc1nn(C(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 1610 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a014 | ||
| 3941 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a014 | ||
| 3961 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a014 | ||
| CHEMBL191 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a014 | ||
| 5335625 | 218284 | 11 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 293 | 3 | 1 | 3 | 3.2 | O=C(N/N=C/c1ccccn1)c1ccc(Cl)c(Cl)c1 | nan | ||
| CHEMBL3208035 | 218284 | 11 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 293 | 3 | 1 | 3 | 3.2 | O=C(N/N=C/c1ccccn1)c1ccc(Cl)c(Cl)c1 | nan | ||
| 46495021 | 217455 | 4 | None | 1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 315 | 5 | 1 | 7 | 1.7 | O=C(N/N=C/c1ccccn1)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1 | nan | ||
| CHEMBL3192235 | 217455 | 4 | None | 1 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 315 | 5 | 1 | 7 | 1.7 | O=C(N/N=C/c1ccccn1)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1 | nan | ||
| 14971636 | 233807 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 506 | 10 | 1 | 7 | 6.0 | CCCCc1nc(-c2ccccc2)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL334083 | 233807 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 506 | 10 | 1 | 7 | 6.0 | CCCCc1nc(-c2ccccc2)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 44292040 | 201269 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 601 | 9 | 1 | 9 | 6.9 | CCCCc1nc2ccc(C3CC(c4cc(C)cs4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL295279 | 201269 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 601 | 9 | 1 | 9 | 6.9 | CCCCc1nc2ccc(C3CC(c4cc(C)cs4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 5759185 | 82127 | 6 | None | -5 | 4 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 300 | 4 | 0 | 6 | 2.8 | CC(C)(C)C(=O)/C(=C\c1cccc([N+](=O)[O-])c1)n1cncn1 | nan | ||
| CHEMBL1465592 | 82127 | 6 | None | -5 | 4 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 300 | 4 | 0 | 6 | 2.8 | CC(C)(C)C(=O)/C(=C\c1cccc([N+](=O)[O-])c1)n1cncn1 | nan | ||
| 44634573 | 5612 | 1 | None | -1122 | 14 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 465 | 6 | 0 | 2 | 5.0 | Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 | 10.6019/CHEMBL5442687 | ||
| 9168 | 5612 | 1 | None | -1122 | 14 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 465 | 6 | 0 | 2 | 5.0 | Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 | 10.6019/CHEMBL5442687 | ||
| CHEMBL1474387 | 5612 | 1 | None | -1122 | 14 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 465 | 6 | 0 | 2 | 5.0 | Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 | 10.6019/CHEMBL5442687 | ||
| CHEMBL1622930 | 5612 | 1 | None | -1122 | 14 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 465 | 6 | 0 | 2 | 5.0 | Cc1n(C/C=C/c2ccccc2)c2[n+](c1P(=S)(c1ccccc1)c1ccccc1)cccc2 | 10.6019/CHEMBL5442687 | ||
| 5217512 | 85818 | 2 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 278 | 3 | 3 | 5 | 2.8 | NNc1nc(-c2ccccc2)cc(-c2ccccc2O)n1 | nan | ||
| CHEMBL1498886 | 85818 | 2 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 278 | 3 | 3 | 5 | 2.8 | NNc1nc(-c2ccccc2)cc(-c2ccccc2O)n1 | nan | ||
| 10371403 | 139210 | 20 | None | None | None | Rabbit | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 601 | 13 | 1 | 10 | 5.8 | CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N+](=O)[O-])c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm049681p | ||
| CHEMBL186572 | 139210 | 20 | None | None | None | Rabbit | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 601 | 13 | 1 | 10 | 5.8 | CCCCc1nc(Cl)c(COC(=O)c2cccc(CO[N+](=O)[O-])c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm049681p | ||
| 14956743 | 329058 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL420970 | 329058 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 56991879 | 143101 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 528 | 13 | 1 | 8 | 4.9 | CCCCc1nc(CCC)c(CCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951121 | 143101 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 528 | 13 | 1 | 8 | 4.9 | CCCCc1nc(CCC)c(CCC(=O)OCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 1692 | 4398 | 23 | None | -144 | 17 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 411 | 6 | 2 | 4 | 5.5 | CCc1ccc(cc1)OCc1ccccc1C(=O)Nc1ccc2c(c1)c(N)cc(n2)C | 10.6019/CHEMBL5442687 | ||
| 5311340 | 4398 | 23 | None | -144 | 17 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 411 | 6 | 2 | 4 | 5.5 | CCc1ccc(cc1)OCc1ccccc1C(=O)Nc1ccc2c(c1)c(N)cc(n2)C | 10.6019/CHEMBL5442687 | ||
| CHEMBL140979 | 4398 | 23 | None | -144 | 17 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 411 | 6 | 2 | 4 | 5.5 | CCc1ccc(cc1)OCc1ccccc1C(=O)Nc1ccc2c(c1)c(N)cc(n2)C | 10.6019/CHEMBL5442687 | ||
| 9618012 | 159501 | 7 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 289 | 3 | 1 | 3 | 3.4 | C/C(=N\NC(=O)c1cccc2ccccc12)c1ccccn1 | nan | ||
| CHEMBL2094484 | 159501 | 7 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 289 | 3 | 1 | 3 | 3.4 | C/C(=N\NC(=O)c1cccc2ccccc12)c1ccccn1 | nan | ||
| 1475345 | 62892 | 9 | None | -1 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 418 | 6 | 1 | 4 | 4.3 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccccc2Cl)cn1 | nan | ||
| CHEMBL1382438 | 62892 | 9 | None | -1 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 418 | 6 | 1 | 4 | 4.3 | COc1ccc(NC(=O)/C(Cl)=C(/Cl)[S+]([O-])Cc2ccccc2Cl)cn1 | nan | ||
| 18666499 | 349612 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 591 | 9 | 2 | 9 | 4.7 | CCCCc1nc2ccc([C@]3(C(=O)O)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL45805 | 349612 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 591 | 9 | 2 | 9 | 4.7 | CCCCc1nc2ccc([C@]3(C(=O)O)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 11743704 | 234437 | 0 | None | 3 | 2 | Rabbit | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccc(C)cc1 | 10.1021/jm00078a013 | ||
| CHEMBL335179 | 234437 | 0 | None | 3 | 2 | Rabbit | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 435 | 5 | 0 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C#N)c1ccc(C)cc1 | 10.1021/jm00078a013 | ||
| 44292038 | 346809 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL47873 | 346809 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 5218417 | 58508 | 4 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 285 | 3 | 0 | 2 | 3.9 | CC1CCCN(CC(=O)c2ccc(Cl)c(Cl)c2)C1 | nan | ||
| CHEMBL1344824 | 58508 | 4 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 285 | 3 | 0 | 2 | 3.9 | CC1CCCN(CC(=O)c2ccc(Cl)c(Cl)c2)C1 | nan | ||
| 10411653 | 58119 | 0 | None | 208 | 2 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 454 | 5 | 1 | 5 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C(=O)O | 10.1021/jm00078a013 | ||
| CHEMBL134151 | 58119 | 0 | None | 208 | 2 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 454 | 5 | 1 | 5 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C(=O)O | 10.1021/jm00078a013 | ||
| 9893924 | 19088 | 27 | None | -1 | 7 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 554 | 11 | 3 | 4 | 5.4 | S=C(NCCCc1c[nH]cn1)NCCCN(Cc1ccc(Cl)c(Cl)c1)c1ccc(Br)cn1 | 10.6019/CHEMBL5442687 | ||
| CHEMBL103769 | 19088 | 27 | None | -1 | 7 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 554 | 11 | 3 | 4 | 5.4 | S=C(NCCCc1c[nH]cn1)NCCCN(Cc1ccc(Cl)c(Cl)c1)c1ccc(Br)cn1 | 10.6019/CHEMBL5442687 | ||
| 14956799 | 216555 | 0 | None | None | None | Rabbit | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314590 | 216555 | 0 | None | None | None | Rabbit | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 6873617 | 144629 | 7 | None | -3 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 386 | 4 | 1 | 4 | 4.7 | O=C(N/N=C/c1ccccn1)c1cc(-c2ccc(Cl)cc2)nc2ccccc12 | nan | ||
| CHEMBL1987579 | 144629 | 7 | None | -3 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 386 | 4 | 1 | 4 | 4.7 | O=C(N/N=C/c1ccccn1)c1cc(-c2ccc(Cl)cc2)nc2ccccc12 | nan | ||
| 10367704 | 46173 | 0 | None | 25 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 476 | 5 | 1 | 8 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | ||
| CHEMBL132408 | 46173 | 0 | None | 25 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 476 | 5 | 1 | 8 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | ||
| 131654 | 473370 | 11 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87778 | 473370 | 11 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956748 | 470771 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccc(OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL84627 | 470771 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccc(OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 9887844 | 328199 | 5 | None | None | None | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1021/jm9504722 | ||
| CHEMBL418226 | 328199 | 5 | None | None | None | Guinea pig | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1021/jm9504722 | ||
| 54393565 | 143119 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 541 | 10 | 1 | 8 | 3.6 | CCCCc1nc(C)c(CCC(=O)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951139 | 143119 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 541 | 10 | 1 | 8 | 3.6 | CCCCc1nc(C)c(CCC(=O)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 10004112 | 59220 | 0 | None | 93 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 454 | 9 | 1 | 5 | 5.5 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| CHEMBL135089 | 59220 | 0 | None | 93 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 454 | 9 | 1 | 5 | 5.5 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| 10344052 | 235514 | 0 | None | 107 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 456 | 9 | 1 | 5 | 5.7 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| CHEMBL336738 | 235514 | 0 | None | 107 | 2 | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 456 | 9 | 1 | 5 | 5.7 | CCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| 2583 | 8231 | 75 | None | -2 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.6019/CHEMBL5442687 | ||
| 592 | 8231 | 75 | None | -2 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.6019/CHEMBL5442687 | ||
| 65999 | 8231 | 75 | None | -2 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.6019/CHEMBL5442687 | ||
| CHEMBL1017 | 8231 | 75 | None | -2 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.6019/CHEMBL5442687 | ||
| DB00966 | 8231 | 75 | None | -2 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.6019/CHEMBL5442687 | ||
| 142534191 | 331595 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 559 | 9 | 1 | 8 | 4.2 | CCCCc1nc(C)c(CC(=S)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4284022 | 331595 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 559 | 9 | 1 | 8 | 4.2 | CCCCc1nc(C)c(CC(=S)N2CCOCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 14956758 | 216199 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL314042 | 216199 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956769 | 216759 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 499 | 9 | 1 | 7 | 5.3 | CCCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL316052 | 216759 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 499 | 9 | 1 | 7 | 5.3 | CCCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956762 | 199071 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 519 | 8 | 1 | 7 | 5.6 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL278741 | 199071 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 519 | 8 | 1 | 7 | 5.6 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 54479908 | 143121 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 525 | 10 | 1 | 7 | 4.3 | CCCCc1nc(C)c(CCC(=O)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951140 | 143121 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 525 | 10 | 1 | 7 | 4.3 | CCCCc1nc(C)c(CCC(=O)N2CCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14956759 | 470888 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 495 | 9 | 2 | 8 | 4.0 | CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85704 | 470888 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 495 | 9 | 2 | 8 | 4.0 | CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956800 | 470935 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86143 | 470935 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 1610 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| 3941 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| 3961 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| CHEMBL191 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00069a015 | ||
| 14956805 | 473316 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 515 | 10 | 1 | 8 | 5.0 | CCCCc1nn(COc2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87354 | 473316 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 515 | 10 | 1 | 8 | 5.0 | CCCCc1nn(COc2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 9893748 | 356343 | 0 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 549 | 9 | 2 | 9 | 4.5 | CCCCc1nc2ccc(C3CC(C(=O)O)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL47872 | 356343 | 0 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 549 | 9 | 2 | 9 | 4.5 | CCCCc1nc2ccc(C3CC(C(=O)O)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 742856 | 116630 | 13 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 279 | 4 | 1 | 2 | 4.3 | O=C(CNc1cccc(Cl)c1)c1ccc(Cl)cc1 | nan | ||
| CHEMBL1603871 | 116630 | 13 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 279 | 4 | 1 | 2 | 4.3 | O=C(CNc1cccc(Cl)c1)c1ccc(Cl)cc1 | nan | ||
| 14956789 | 473406 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 489 | 10 | 1 | 9 | 3.7 | CCCCc1nn(C(C(=O)OC)C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL88002 | 473406 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 489 | 10 | 1 | 9 | 3.7 | CCCCc1nn(C(C(=O)OC)C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 2811329 | 62311 | 2 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 279 | 3 | 2 | 4 | 3.0 | Cc1ccc(NNC(=O)c2c(C)noc2C)cc1Cl | nan | ||
| CHEMBL1377329 | 62311 | 2 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 279 | 3 | 2 | 4 | 3.0 | Cc1ccc(NNC(=O)c2c(C)noc2C)cc1Cl | nan | ||
| 4328866 | 43343 | 3 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 247 | 3 | 0 | 4 | 1.2 | CC(C)OC(=O)CN1C(=O)C(=O)c2ccccc21 | nan | ||
| CHEMBL1299266 | 43343 | 3 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 247 | 3 | 0 | 4 | 1.2 | CC(C)OC(=O)CN1C(=O)C(=O)c2ccccc21 | nan | ||
| 5770964 | 60129 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 444 | 9 | 2 | 6 | 2.6 | COc1ccc(C(=O)/C=C/C(=O)N(CC(=O)NC2CCCCC2)CC2CCCO2)c(O)c1 | nan | ||
| CHEMBL1359902 | 60129 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 444 | 9 | 2 | 6 | 2.6 | COc1ccc(C(=O)/C=C/C(=O)N(CC(=O)NC2CCCCC2)CC2CCCO2)c(O)c1 | nan | ||
| 2744279 | 60331 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 351 | 5 | 0 | 10 | 2.5 | CCn1nc(C)cc1-c1nnc(Sc2ncc([N+](=O)[O-])s2)n1C | nan | ||
| CHEMBL1361740 | 60331 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 351 | 5 | 0 | 10 | 2.5 | CCn1nc(C)cc1-c1nnc(Sc2ncc([N+](=O)[O-])s2)n1C | nan | ||
| 4068403 | 44571 | 10 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 360 | 4 | 1 | 6 | 4.0 | O=C(Nc1nc(-c2ccccn2)cs1)c1cc(Cl)ccc1[N+](=O)[O-] | nan | ||
| CHEMBL1309127 | 44571 | 10 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 360 | 4 | 1 | 6 | 4.0 | O=C(Nc1nc(-c2ccccn2)cs1)c1cc(Cl)ccc1[N+](=O)[O-] | nan | ||
| 1610 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a013 | ||
| 1610 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a014 | ||
| 3941 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a013 | ||
| 3941 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a014 | ||
| 3961 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a013 | ||
| 3961 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a014 | ||
| CHEMBL191 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a013 | ||
| CHEMBL191 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00078a014 | ||
| 788411 | 61036 | 8 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 273 | 4 | 1 | 2 | 4.3 | Cc1ccc(C(=O)CNc2ccc(C)c(Cl)c2)cc1 | nan | ||
| CHEMBL1367827 | 61036 | 8 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 273 | 4 | 1 | 2 | 4.3 | Cc1ccc(C(=O)CNc2ccc(C)c(Cl)c2)cc1 | nan | ||
| 14971674 | 474202 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 540 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2cccc(Cl)c2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL93289 | 474202 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 540 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2cccc(Cl)c2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 15233933 | 193778 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL295532 | 193778 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 14971693 | 222369 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 560 | 9 | 1 | 7 | 6.5 | CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL331063 | 222369 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 560 | 9 | 1 | 7 | 6.5 | CCCc1nn(-c2ccccc2C(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 18655851 | 201431 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 623 | 9 | 1 | 8 | 6.7 | CCCCc1nc2ccc([C@]3(c4ccccc4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL296519 | 201431 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 623 | 9 | 1 | 8 | 6.7 | CCCCc1nc2ccc([C@]3(c4ccccc4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 100520 | 66349 | 2 | None | -4 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 240 | 3 | 0 | 7 | 2.0 | O=[N+]([O-])c1cnc(Sc2ccncn2)s1 | nan | ||
| CHEMBL1413680 | 66349 | 2 | None | -4 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 240 | 3 | 0 | 7 | 2.0 | O=[N+]([O-])c1cnc(Sc2ccncn2)s1 | nan | ||
| 788410 | 45017 | 10 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 259 | 4 | 1 | 2 | 3.9 | Cc1ccc(NCC(=O)c2ccccc2)cc1Cl | nan | ||
| CHEMBL1312651 | 45017 | 10 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 259 | 4 | 1 | 2 | 3.9 | Cc1ccc(NCC(=O)c2ccccc2)cc1Cl | nan | ||
| 44292072 | 201430 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 618 | 9 | 1 | 9 | 4.7 | CCCCc1nc2ccc([C@]3(C(=O)N(C)C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL296518 | 201430 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 618 | 9 | 1 | 9 | 4.7 | CCCCc1nc2ccc([C@]3(C(=O)N(C)C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 14956773 | 470881 | 0 | None | None | None | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 504 | 9 | 2 | 6 | 5.0 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL85659 | 470881 | 0 | None | None | None | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 504 | 9 | 2 | 6 | 5.0 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00069a015 | ||
| 44292162 | 336815 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 575 | 9 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@@]3(CC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL44749 | 336815 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 575 | 9 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@@]3(CC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 16446380 | 65249 | 8 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 447 | 7 | 1 | 7 | 3.4 | COc1ccc(OC)c(NC(=O)c2nc(S(=O)(=O)Cc3ccccc3)ncc2Cl)c1 | nan | ||
| CHEMBL1404578 | 65249 | 8 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 447 | 7 | 1 | 7 | 3.4 | COc1ccc(OC)c(NC(=O)c2nc(S(=O)(=O)Cc3ccccc3)ncc2Cl)c1 | nan | ||
| 718402 | 77379 | 10 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 300 | 5 | 0 | 6 | 2.6 | COc1cc(/C=C/[N+](=O)[O-])ccc1OC(=O)c1cccnc1 | nan | ||
| CHEMBL1423567 | 77379 | 10 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 300 | 5 | 0 | 6 | 2.6 | COc1cc(/C=C/[N+](=O)[O-])ccc1OC(=O)c1cccnc1 | nan | ||
| 16437205 | 65630 | 8 | None | -5 | 3 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 486 | 6 | 1 | 7 | 2.7 | CCC1CCCCN1S(=O)(=O)c1ccc(NC(=O)c2nc(S(C)(=O)=O)ncc2Cl)cc1 | nan | ||
| CHEMBL1407961 | 65630 | 8 | None | -5 | 3 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 486 | 6 | 1 | 7 | 2.7 | CCC1CCCCN1S(=O)(=O)c1ccc(NC(=O)c2nc(S(C)(=O)=O)ncc2Cl)cc1 | nan | ||
| 6873485 | 217211 | 9 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 410 | 7 | 1 | 5 | 4.9 | CCCOc1cccc(-c2cc(C(=O)N/N=C/c3ccccn3)c3ccccc3n2)c1 | nan | ||
| CHEMBL3189289 | 217211 | 9 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 410 | 7 | 1 | 5 | 4.9 | CCCOc1cccc(-c2cc(C(=O)N/N=C/c3ccccn3)c3ccccc3n2)c1 | nan | ||
| 9569064 | 144469 | 1 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 363 | 6 | 1 | 4 | 4.0 | C/C(=N\NC(=O)c1ccccc1OCc1ccc(F)cc1)c1ccccn1 | nan | ||
| CHEMBL1981898 | 144469 | 1 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 363 | 6 | 1 | 4 | 4.0 | C/C(=N\NC(=O)c1ccccc1OCc1ccc(F)cc1)c1ccccn1 | nan | ||
| 1481 | 7955 | 73 | None | -8 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| 3749 | 7955 | 73 | None | -8 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| 6908 | 7955 | 73 | None | -8 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL1513 | 7955 | 73 | None | -8 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/acsmedchemlett.1c00240 | ||
| 108185 | 3317 | 57 | None | -3 | 4 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00069a015 | ||
| 586 | 3317 | 57 | None | -3 | 4 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00069a015 | ||
| CHEMBL907 | 3317 | 57 | None | -3 | 4 | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00069a015 | ||
| 57393229 | 143126 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 555 | 9 | 1 | 7 | 5.5 | CCCCc1nc(C)c(CC(=S)N2CCCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951145 | 143126 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 555 | 9 | 1 | 7 | 5.5 | CCCCc1nc(C)c(CC(=S)N2CCCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14956740 | 470617 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL83248 | 470617 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14971677 | 221010 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL327837 | 221010 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2ccc(Cl)cc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956775 | 468943 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 375 | 7 | 2 | 7 | 3.2 | CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL69508 | 468943 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 375 | 7 | 2 | 7 | 3.2 | CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956808 | 473398 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 580 | 13 | 1 | 9 | 4.9 | CCCCc1nn(CCCN(C)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87957 | 473398 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 580 | 13 | 1 | 9 | 4.9 | CCCCc1nn(CCCN(C)C(=O)OCc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 330973 | 102930 | 0 | None | -3 | 3 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 592 | 4 | 0 | 10 | 3.0 | C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 | nan | ||
| CHEMBL1566610 | 102930 | 0 | None | -3 | 3 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 592 | 4 | 0 | 10 | 3.0 | C=C1C(=O)O[C@@H]2C[C@@H](C)[C@@H]3C=CC(=O)[C@@]3(C)[C@@H](OC(=O)CC(=O)O[C@H]3[C@@H]4C(=C)C(=O)O[C@@H]4C[C@@H](C)[C@@H]4C=CC(=O)[C@@]34C)[C@H]12 | nan | ||
| 2812572 | 58716 | 2 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 274 | 4 | 2 | 2 | 3.7 | CCc1ccc(C(=O)NNc2ccc(Cl)cc2)cc1 | nan | ||
| CHEMBL1346661 | 58716 | 2 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 274 | 4 | 2 | 2 | 3.7 | CCc1ccc(C(=O)NNc2ccc(Cl)cc2)cc1 | nan | ||
| 890649 | 106840 | 12 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 342 | 3 | 0 | 6 | 3.6 | O=S1(=O)C=C(Sc2nnc(-c3ccccc3)o2)c2ccccc21 | nan | ||
| CHEMBL1602759 | 106840 | 12 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 342 | 3 | 0 | 6 | 3.6 | O=S1(=O)C=C(Sc2nnc(-c3ccccc3)o2)c2ccccc21 | nan | ||
| 44292456 | 201296 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 658 | 9 | 1 | 9 | 5.6 | CCCCc1nc2ccc(C3(C(=O)N4CCCCC4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL295514 | 201296 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 658 | 9 | 1 | 9 | 5.6 | CCCCc1nc2ccc(C3(C(=O)N4CCCCC4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 1610 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2011.12.116 | ||
| 3941 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2011.12.116 | ||
| 3961 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL191 | 7967 | 67 | None | -2 | 8 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2011.12.116 | ||
| 16436607 | 57761 | 9 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 486 | 6 | 1 | 7 | 2.6 | CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N3CCC(C)CC3)cc2)n1 | nan | ||
| CHEMBL1338304 | 57761 | 9 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 486 | 6 | 1 | 7 | 2.6 | CCS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(S(=O)(=O)N3CCC(C)CC3)cc2)n1 | nan | ||
| 9619214 | 217698 | 6 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 351 | 5 | 1 | 8 | 2.9 | Cc1cc(N/N=C/c2ccccc2[N+](=O)[O-])nc(-n2nc(C)cc2C)n1 | nan | ||
| CHEMBL3195226 | 217698 | 6 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 351 | 5 | 1 | 8 | 2.9 | Cc1cc(N/N=C/c2ccccc2[N+](=O)[O-])nc(-n2nc(C)cc2C)n1 | nan | ||
| 11744592 | 234441 | 0 | None | 33 | 2 | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 452 | 6 | 0 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)OC)c1 | 10.1021/jm00078a013 | ||
| CHEMBL335228 | 234441 | 0 | None | 33 | 2 | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 452 | 6 | 0 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2C(=O)OC)c1 | 10.1021/jm00078a013 | ||
| 6091989 | 103092 | 6 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 337 | 5 | 1 | 5 | 4.1 | COc1cc(/C=C/c2ccc3cccc(O)c3n2)cc(OC)c1OC | nan | ||
| CHEMBL1567899 | 103092 | 6 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 337 | 5 | 1 | 5 | 4.1 | COc1cc(/C=C/c2ccc3cccc(O)c3n2)cc(OC)c1OC | nan | ||
| 42611190 | 6416 | 21 | None | -1479 | 21 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL5442687 | ||
| 5802 | 6416 | 21 | None | -1479 | 21 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL5442687 | ||
| CHEMBL1800685 | 6416 | 21 | None | -1479 | 21 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL5442687 | ||
| 44292070 | 327833 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 589 | 8 | 1 | 8 | 6.4 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL44690 | 327833 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 589 | 8 | 1 | 8 | 6.4 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 44292342 | 351211 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.3 | CCCCc1nc2ccc([C@@H]3C[C@@]4(C)CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL46361 | 351211 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 575 | 8 | 1 | 8 | 6.3 | CCCCc1nc2ccc([C@@H]3C[C@@]4(C)CCCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 6883924 | 143919 | 8 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 315 | 3 | 1 | 4 | 3.7 | O=C(N/N=C/c1ccccn1)c1sc2ccccc2c1Cl | nan | ||
| CHEMBL1964873 | 143919 | 8 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 315 | 3 | 1 | 4 | 3.7 | O=C(N/N=C/c1ccccn1)c1sc2ccccc2c1Cl | nan | ||
| 10366811 | 58520 | 0 | None | 31 | 2 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 456 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cccc(C)c2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL134491 | 58520 | 0 | None | 31 | 2 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 456 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cccc(C)c2)cc1 | 10.1021/jm00078a014 | ||
| 3117 | 474710 | 66 | None | -18 | 17 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | nan | ||
| 928 | 474710 | 66 | None | -18 | 17 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | nan | ||
| CHEMBL964 | 474710 | 66 | None | -18 | 17 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | nan | ||
| DB00822 | 474710 | 66 | None | -18 | 17 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 296 | 4 | 0 | 4 | 3.6 | CCN(CC)C(=S)SSC(=S)N(CC)CC | nan | ||
| 780062 | 62605 | 5 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 276 | 3 | 2 | 4 | 3.4 | Cc1ccc(-c2cc(-c3ccccc3)nc(NN)n2)cc1 | nan | ||
| CHEMBL1380035 | 62605 | 5 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 276 | 3 | 2 | 4 | 3.4 | Cc1ccc(-c2cc(-c3ccccc3)nc(NN)n2)cc1 | nan | ||
| 10048602 | 59738 | 0 | None | 37 | 2 | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 435 | 4 | 0 | 5 | 4.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C#N | 10.1021/jm00078a013 | ||
| CHEMBL135522 | 59738 | 0 | None | 37 | 2 | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 435 | 4 | 0 | 5 | 4.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1C#N | 10.1021/jm00078a013 | ||
| 9556585 | 310920 | 9 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 303 | 3 | 1 | 3 | 2.6 | O=C(N/N=C/c1ccccn1)c1ccc(Br)cc1 | nan | ||
| CHEMBL400912 | 310920 | 9 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 303 | 3 | 1 | 3 | 2.6 | O=C(N/N=C/c1ccccn1)c1ccc(Br)cc1 | nan | ||
| 14956800 | 470935 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86143 | 470935 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956810 | 470944 | 0 | None | None | None | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 566 | 10 | 1 | 8 | 5.9 | CCCCc1nn(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86232 | 470944 | 0 | None | None | None | Rabbit | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 566 | 10 | 1 | 8 | 5.9 | CCCCc1nn(Cc2ccc(-c3ccccc3C#N)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 135449568 | 85084 | 2 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 286 | 4 | 2 | 7 | 2.5 | COCc1cc(O)nc(Nc2nc3ccc(C)cc3o2)n1 | nan | ||
| CHEMBL1492017 | 85084 | 2 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 286 | 4 | 2 | 7 | 2.5 | COCc1cc(O)nc(Nc2nc3ccc(C)cc3o2)n1 | nan | ||
| 44292428 | 201229 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 644 | 9 | 1 | 9 | 5.3 | CCCCc1nc2ccc(C3(C(=O)N4CCCC4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL294992 | 201229 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 644 | 9 | 1 | 9 | 5.3 | CCCCc1nc2ccc(C3(C(=O)N4CCCC4)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 44291956 | 335814 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 619 | 10 | 1 | 10 | 5.3 | CCCCc1nc2ccc([C@H]3ON4CCCC4C3C(=O)OCC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL44605 | 335814 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 619 | 10 | 1 | 10 | 5.3 | CCCCc1nc2ccc([C@H]3ON4CCCC4C3C(=O)OCC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 14956746 | 473179 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86440 | 473179 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 379338 | 40771 | 22 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 288 | 2 | 0 | 4 | 3.4 | COc1ccc(-c2cc3c(nn2)-c2ccccc2C3=O)cc1 | nan | ||
| CHEMBL125044 | 40771 | 22 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 288 | 2 | 0 | 4 | 3.4 | COc1ccc(-c2cc3c(nn2)-c2ccccc2C3=O)cc1 | nan | ||
| 14956807 | 215807 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 566 | 12 | 1 | 9 | 4.9 | CCCCc1nn(CCCOC(=O)N(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313435 | 215807 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 566 | 12 | 1 | 9 | 4.9 | CCCCc1nn(CCCOC(=O)N(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956755 | 215829 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccccc2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313579 | 215829 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccccc2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10202093 | 473402 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 417 | 8 | 1 | 7 | 3.9 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87985 | 473402 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 417 | 8 | 1 | 7 | 3.9 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 145987183 | 332024 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 597 | 9 | 1 | 7 | 6.1 | CCCCc1nc(C)c(CC(=S)N2CC[C@@H]3CCCC[C@H]32)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| CHEMBL4292297 | 332024 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 597 | 9 | 1 | 7 | 6.1 | CCCCc1nc(C)c(CC(=S)N2CC[C@@H]3CCCC[C@H]32)c(=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmcl.2018.08.036 | ||
| 44291955 | 196960 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 589 | 8 | 1 | 8 | 6.4 | CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL263471 | 196960 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 589 | 8 | 1 | 8 | 6.4 | CCCCc1nc2ccc([C@@]3(C)C[C@H]4CCC(C)(C)N4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 18942289 | 201460 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 595 | 9 | 1 | 8 | 6.8 | CCCCc1nc2ccc(C3CC(c4ccc(C)cc4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL296719 | 201460 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 595 | 9 | 1 | 8 | 6.8 | CCCCc1nc2ccc(C3CC(c4ccc(C)cc4)=NO3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 10003482 | 330612 | 0 | None | 158 | 2 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 442 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
| CHEMBL424643 | 330612 | 0 | None | 158 | 2 | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 442 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)c(C)c1 | 10.1021/jm00078a014 | ||
| 14956776 | 215653 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 389 | 7 | 1 | 7 | 2.8 | CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313017 | 215653 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 389 | 7 | 1 | 7 | 2.8 | CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956790 | 335889 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 475 | 10 | 2 | 8 | 3.6 | CCCCc1nn(C(C(=O)O)C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL446152 | 335889 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 475 | 10 | 2 | 8 | 3.6 | CCCCc1nn(C(C(=O)O)C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 851388 | 118064 | 10 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 229 | 4 | 1 | 2 | 3.1 | O=C(CNc1ccc(F)cc1)c1ccccc1 | nan | ||
| CHEMBL1617841 | 118064 | 10 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 229 | 4 | 1 | 2 | 3.1 | O=C(CNc1ccc(F)cc1)c1ccccc1 | nan | ||
| 1728272 | 98121 | 8 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 309 | 5 | 3 | 4 | 1.5 | CCCOc1ccc(C(=O)NNC(=S)NC(=O)CC)cc1 | nan | ||
| CHEMBL1522211 | 98121 | 8 | None | 1 | 2 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 309 | 5 | 3 | 4 | 1.5 | CCCOc1ccc(C(=O)NNC(=S)NC(=O)CC)cc1 | nan | ||
| 135411933 | 84641 | 17 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 300 | 1 | 1 | 2 | 3.5 | O=C1Nc2ccccc2C1=Nc1ccc(Br)cc1 | nan | ||
| CHEMBL1488802 | 84641 | 17 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 300 | 1 | 1 | 2 | 3.5 | O=C1Nc2ccccc2C1=Nc1ccc(Br)cc1 | nan | ||
| 2796987 | 47198 | 2 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 288 | 5 | 2 | 3 | 2.7 | NC(=O)c1ccccc1NCC(=O)c1ccc(Cl)cc1 | nan | ||
| CHEMBL1332717 | 47198 | 2 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 288 | 5 | 2 | 3 | 2.7 | NC(=O)c1ccccc1NCC(=O)c1ccc(Cl)cc1 | nan | ||
| 379337 | 329156 | 22 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 258 | 1 | 0 | 3 | 3.4 | O=C1c2ccccc2-c2nnc(-c3ccccc3)cc21 | nan | ||
| CHEMBL421088 | 329156 | 22 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 258 | 1 | 0 | 3 | 3.4 | O=C1c2ccccc2-c2nnc(-c3ccccc3)cc21 | nan | ||
| 788612 | 105554 | 7 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 303 | 4 | 1 | 2 | 4.1 | Cc1ccc(C(=O)CNc2ccc(Br)cc2)cc1 | nan | ||
| CHEMBL1589540 | 105554 | 7 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 303 | 4 | 1 | 2 | 4.1 | Cc1ccc(C(=O)CNc2ccc(Br)cc2)cc1 | nan | ||
| 583493 | 86151 | 4 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 255 | 5 | 2 | 3 | 2.7 | O=C(CNc1ccccc1C(=O)O)c1ccccc1 | nan | ||
| CHEMBL1501792 | 86151 | 4 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 255 | 5 | 2 | 3 | 2.7 | O=C(CNc1ccccc1C(=O)O)c1ccccc1 | nan | ||
| 1593681 | 64013 | 7 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 423 | 9 | 2 | 8 | 1.1 | O=C(CNC(=O)c1ccco1)NCC(=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1391919 | 64013 | 7 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 423 | 9 | 2 | 8 | 1.1 | O=C(CNC(=O)c1ccco1)NCC(=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| 10258828 | 38564 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 498 | 9 | 1 | 7 | 5.0 | CCCc1nn(CC(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120549 | 38564 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 498 | 9 | 1 | 7 | 5.0 | CCCc1nn(CC(F)(F)F)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14971696 | 232473 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 572 | 9 | 1 | 7 | 6.7 | CCOC(=O)c1c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CC2CC2)nn1-c1c(Cl)cccc1Cl | 10.1021/jm00075a014 | ||
| CHEMBL331886 | 232473 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 572 | 9 | 1 | 7 | 6.7 | CCOC(=O)c1c(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CC2CC2)nn1-c1c(Cl)cccc1Cl | 10.1021/jm00075a014 | ||
| 14956782 | 473372 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 457 | 8 | 1 | 7 | 3.8 | CCCCc1nn(CC(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87780 | 473372 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 457 | 8 | 1 | 7 | 3.8 | CCCCc1nn(CC(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 44341650 | 334452 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 406 | 7 | 2 | 3 | 4.8 | CCCCC1NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL444060 | 334452 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 406 | 7 | 2 | 3 | 4.8 | CCCCC1NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 135400371 | 106512 | 15 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 314 | 1 | 1 | 2 | 3.8 | Cc1ccc(N=C2C(=O)Nc3ccc(Br)cc32)cc1 | nan | ||
| CHEMBL1599499 | 106512 | 15 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 314 | 1 | 1 | 2 | 3.8 | Cc1ccc(N=C2C(=O)Nc3ccc(Br)cc32)cc1 | nan | ||
| 135403068 | 47328 | 10 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 358 | 3 | 1 | 3 | 4.2 | CCOc1ccc(N=C2C(=O)Nc3ccc(C)c(Br)c32)cc1 | nan | ||
| CHEMBL1333730 | 47328 | 10 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 358 | 3 | 1 | 3 | 4.2 | CCOc1ccc(N=C2C(=O)Nc3ccc(C)c(Br)c32)cc1 | nan | ||
| 6884203 | 217858 | 9 | None | -1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 352 | 4 | 1 | 4 | 4.1 | O=C(N/N=C/c1ccccn1)c1cc(-c2ccccc2)nc2ccccc12 | nan | ||
| CHEMBL3197021 | 217858 | 9 | None | -1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 352 | 4 | 1 | 4 | 4.1 | O=C(N/N=C/c1ccccn1)c1cc(-c2ccccc2)nc2ccccc12 | nan | ||
| 2989697 | 101995 | 12 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 377 | 5 | 1 | 6 | 2.4 | CS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(OC(F)F)cc2)n1 | nan | ||
| CHEMBL1558462 | 101995 | 12 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 377 | 5 | 1 | 6 | 2.4 | CS(=O)(=O)c1ncc(Cl)c(C(=O)Nc2ccc(OC(F)F)cc2)n1 | nan | ||
| 10435200 | 47683 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 478 | 5 | 1 | 7 | 4.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1-c1nn[nH]n1 | 10.1021/jm00078a013 | ||
| CHEMBL133654 | 47683 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 478 | 5 | 1 | 7 | 4.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(=O)c1ccccc1-c1nn[nH]n1 | 10.1021/jm00078a013 | ||
| 5953874 | 84528 | 3 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 277 | 2 | 1 | 6 | 2.8 | N=C1S/C(=C\c2ccco2)C(=O)N1c1nccs1 | nan | ||
| CHEMBL1488024 | 84528 | 3 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 277 | 2 | 1 | 6 | 2.8 | N=C1S/C(=C\c2ccco2)C(=O)N1c1nccs1 | nan | ||
| 9675542 | 217437 | 4 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 273 | 3 | 1 | 3 | 2.8 | Cc1cccc(/C=N/NC(=O)c2cccc(Cl)c2)n1 | nan | ||
| CHEMBL3191999 | 217437 | 4 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 273 | 3 | 1 | 3 | 2.8 | Cc1cccc(/C=N/NC(=O)c2cccc(Cl)c2)n1 | nan | ||
| 44292215 | 349441 | 0 | None | None | None | Bovine | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 605 | 9 | 1 | 10 | 4.8 | CCCCc1nc2ccc([C@]3(C(=O)OC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL45766 | 349441 | 0 | None | None | None | Bovine | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 605 | 9 | 1 | 10 | 4.8 | CCCCc1nc2ccc([C@]3(C(=O)OC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 14956774 | 473219 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 452 | 8 | 1 | 8 | 3.7 | CCCCc1nn(-c2ccccn2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86741 | 473219 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 452 | 8 | 1 | 8 | 3.7 | CCCCc1nn(-c2ccccn2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 6873171 | 218314 | 6 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 283 | 2 | 1 | 3 | 1.9 | S=C(N/N=C/c1ccc(Cl)cc1)N1CCOCC1 | nan | ||
| CHEMBL3208447 | 218314 | 6 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 283 | 2 | 1 | 3 | 1.9 | S=C(N/N=C/c1ccc(Cl)cc1)N1CCOCC1 | nan | ||
| 14971678 | 38452 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL120290 | 38452 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 10365283 | 59543 | 0 | None | 416 | 2 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL135345 | 59543 | 0 | None | 416 | 2 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 428 | 7 | 1 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| 10223724 | 470571 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 417 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL82797 | 470571 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 417 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 10479472 | 234208 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 462 | 6 | 1 | 7 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | ||
| CHEMBL334660 | 234208 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 462 | 6 | 1 | 7 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2Cc2ccccc2-c2nn[nH]n2)c1 | 10.1021/jm00078a013 | ||
| 10344235 | 470945 | 0 | None | -1 | 2 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 460 | 5 | 1 | 7 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 | 10.1021/jm0603163 | ||
| CHEMBL86247 | 470945 | 0 | None | -1 | 2 | Rabbit | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 460 | 5 | 1 | 7 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 | 10.1021/jm0603163 | ||
| 10322504 | 60059 | 0 | None | 19 | 2 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 470 | 9 | 1 | 5 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C(C)CC)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL135929 | 60059 | 0 | None | 19 | 2 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 470 | 9 | 1 | 5 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(C(C)CC)C(C(=O)O)c2ccccc2)cc1 | 10.1021/jm00078a014 | ||
| 14956747 | 470772 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL84630 | 470772 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14971673 | 221846 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 506 | 10 | 1 | 7 | 5.8 | CCCCc1nn(-c2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL329466 | 221846 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 506 | 10 | 1 | 7 | 5.8 | CCCCc1nn(-c2ccccc2)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 5339648 | 145161 | 14 | None | 1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 270 | 4 | 1 | 5 | 1.8 | O=C(N/N=C/c1ccccn1)c1cccc([N+](=O)[O-])c1 | nan | ||
| CHEMBL2005961 | 145161 | 14 | None | 1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 270 | 4 | 1 | 5 | 1.8 | O=C(N/N=C/c1ccccn1)c1cccc([N+](=O)[O-])c1 | nan | ||
| 10322995 | 234245 | 0 | None | 134 | 2 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 482 | 9 | 1 | 5 | 6.1 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1C | 10.1021/jm00078a014 | ||
| CHEMBL334832 | 234245 | 0 | None | 134 | 2 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 482 | 9 | 1 | 5 | 6.1 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1C)C(C(=O)O)c1ccccc1C | 10.1021/jm00078a014 | ||
| 10026268 | 235804 | 0 | None | 173 | 2 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 440 | 6 | 1 | 5 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)O)c1ccccc1 | 10.1021/jm00078a013 | ||
| CHEMBL338505 | 235804 | 0 | None | 173 | 2 | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 440 | 6 | 1 | 5 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(C(=O)O)c1ccccc1 | 10.1021/jm00078a013 | ||
| 854200 | 79502 | 6 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 239 | 4 | 1 | 2 | 3.6 | Cc1ccc(C(=O)CNc2ccccc2C)cc1 | nan | ||
| CHEMBL1443417 | 79502 | 6 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 239 | 4 | 1 | 2 | 3.6 | Cc1ccc(C(=O)CNc2ccccc2C)cc1 | nan | ||
| 973504 | 195596 | 8 | None | -1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 343 | 4 | 1 | 5 | 3.3 | Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL256042 | 195596 | 8 | None | -1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 343 | 4 | 1 | 5 | 3.3 | Cc1ccc(S(=O)(=O)Nc2cccc3cccnc23)c([N+](=O)[O-])c1 | nan | ||
| 44292180 | 346794 | 0 | None | None | None | Bovine | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 575 | 9 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@]3(CC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| CHEMBL47583 | 346794 | 0 | None | None | None | Bovine | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 575 | 9 | 1 | 8 | 6.0 | CCCCc1nc2ccc([C@]3(CC)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80365-0 | ||
| 200953 | 99115 | 4 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 196 | 1 | 0 | 2 | 2.5 | O=C(C#Cc1ccccc1)c1ccco1 | nan | ||
| CHEMBL1531308 | 99115 | 4 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 196 | 1 | 0 | 2 | 2.5 | O=C(C#Cc1ccccc1)c1ccco1 | nan | ||
| 2812483 | 86999 | 2 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 245 | 3 | 2 | 4 | 2.4 | Cc1cc(C(=O)NNc2ccc(C)c(C)c2)no1 | nan | ||
| CHEMBL1509162 | 86999 | 2 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 245 | 3 | 2 | 4 | 2.4 | Cc1cc(C(=O)NNc2ccc(C)c(C)c2)no1 | nan | ||
| 6873172 | 218663 | 12 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 263 | 2 | 1 | 3 | 1.5 | Cc1ccc(/C=N/NC(=S)N2CCOCC2)cc1 | nan | ||
| CHEMBL3213140 | 218663 | 12 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 263 | 2 | 1 | 3 | 1.5 | Cc1ccc(/C=N/NC(=S)N2CCOCC2)cc1 | nan | ||
| 10437543 | 59946 | 0 | None | 7 | 2 | Rabbit | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 550 | 7 | 2 | 5 | 6.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL135819 | 59946 | 0 | None | 7 | 2 | Rabbit | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 550 | 7 | 2 | 5 | 6.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(NC(C(=O)O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 | 10.1021/jm00078a014 | ||
| 878879 | 81636 | 7 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 303 | 4 | 1 | 2 | 4.1 | Cc1ccccc1NCC(=O)c1ccc(Br)cc1 | nan | ||
| CHEMBL1461745 | 81636 | 7 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 303 | 4 | 1 | 2 | 4.1 | Cc1ccccc1NCC(=O)c1ccc(Br)cc1 | nan | ||
| 44341785 | 24446 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 438 | 6 | 1 | 3 | 5.3 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2Cc2ccccc2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| CHEMBL115771 | 24446 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 438 | 6 | 1 | 3 | 5.3 | O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2Cc2ccccc2)cc1 | 10.1021/acsmedchemlett.1c00240 | ||
| 6792924 | 217612 | 7 | None | 1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 259 | 3 | 1 | 3 | 2.5 | O=C(N/N=C/c1ccccn1)c1ccc(Cl)cc1 | nan | ||
| CHEMBL3194040 | 217612 | 7 | None | 1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 259 | 3 | 1 | 3 | 2.5 | O=C(N/N=C/c1ccccn1)c1ccc(Cl)cc1 | nan | ||
| 1511959 | 44975 | 7 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 359 | 3 | 0 | 8 | 2.0 | CC(=O)C1=C(c2cccc([N+](=O)[O-])c2)N(C(C)=O)n2c(C)nnc2S1 | nan | ||
| CHEMBL1312377 | 44975 | 7 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 359 | 3 | 0 | 8 | 2.0 | CC(=O)C1=C(c2cccc([N+](=O)[O-])c2)N(C(C)=O)n2c(C)nnc2S1 | nan | ||
| 10050755 | 234449 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 478 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(F)ccc2F)cc1 | 10.1021/jm00078a014 | ||
| CHEMBL335276 | 234449 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 478 | 8 | 1 | 5 | 5.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(N(CC)C(C(=O)O)c2cc(F)ccc2F)cc1 | 10.1021/jm00078a014 | ||
| 54508770 | 143105 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 472 | 10 | 2 | 7 | 3.8 | CCCCc1nc(C)c(CCC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951125 | 143105 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 472 | 10 | 2 | 7 | 3.8 | CCCCc1nc(C)c(CCC(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14971682 | 220986 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 551 | 11 | 1 | 9 | 5.7 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL327718 | 220986 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 551 | 11 | 1 | 9 | 5.7 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956771 | 473325 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 482 | 8 | 1 | 9 | 3.8 | CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87392 | 473325 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 482 | 8 | 1 | 9 | 3.8 | CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 57393228 | 143122 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 539 | 10 | 1 | 7 | 4.7 | CCCCc1nc(C)c(CCC(=O)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| CHEMBL1951141 | 143122 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 539 | 10 | 1 | 7 | 4.7 | CCCCc1nc(C)c(CCC(=O)N2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2011.12.116 | ||
| 14971676 | 328353 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| CHEMBL419321 | 328353 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 574 | 10 | 1 | 7 | 7.1 | CCCCc1nn(-c2cccc(Cl)c2Cl)c(C(=O)OCC)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00075a014 | ||
| 14956776 | 215653 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 389 | 7 | 1 | 7 | 2.8 | CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL313017 | 215653 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 389 | 7 | 1 | 7 | 2.8 | CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 824082 | 60155 | 7 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 326 | 5 | 0 | 5 | 2.6 | Cc1ccc(OCCN2C(=O)c3ccccc3C2=O)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1360149 | 60155 | 7 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 326 | 5 | 0 | 5 | 2.6 | Cc1ccc(OCCN2C(=O)c3ccccc3C2=O)c([N+](=O)[O-])c1 | nan | ||
| 2564786 | 97986 | 4 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 225 | 4 | 1 | 2 | 3.3 | Cc1ccc(C(=O)CNc2ccccc2)cc1 | nan | ||
| CHEMBL1521054 | 97986 | 4 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 225 | 4 | 1 | 2 | 3.3 | Cc1ccc(C(=O)CNc2ccccc2)cc1 | nan | ||
| 11754335 | 58995 | 0 | None | 186 | 2 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 467 | 5 | 2 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2NC(=O)O)c1 | 10.1021/jm00078a013 | ||
| CHEMBL134901 | 58995 | 0 | None | 186 | 2 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 467 | 5 | 2 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2ccccc2NC(=O)O)c1 | 10.1021/jm00078a013 | ||
| 1625575 | 117134 | 8 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 297 | 5 | 1 | 5 | 1.5 | CCOC(=O)/C=C/S(=O)(=O)c1ccc(NC(C)=O)cc1 | nan | ||
| CHEMBL1608078 | 117134 | 8 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 297 | 5 | 1 | 5 | 1.5 | CCOC(=O)/C=C/S(=O)(=O)c1ccc(NC(C)=O)cc1 | nan | ||
| 5680364 | 117748 | 3 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 272 | 2 | 1 | 4 | 0.9 | CCOC(=O)C1=C2NC(=O)c3ccccc3N2C(=O)C1 | nan | ||
| CHEMBL1613515 | 117748 | 3 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 272 | 2 | 1 | 4 | 0.9 | CCOC(=O)C1=C2NC(=O)c3ccccc3N2C(=O)C1 | nan | ||
| 2411934 | 118277 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 451 | 10 | 2 | 6 | 4.3 | CCOC(=O)c1c(-c2ccc(-c3ccccc3)cc2)csc1NC(=O)CNCCN(C)C | nan | ||
| CHEMBL1619798 | 118277 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 451 | 10 | 2 | 6 | 4.3 | CCOC(=O)c1c(-c2ccc(-c3ccccc3)cc2)csc1NC(=O)CNCCN(C)C | nan | ||
| 2170433 | 99463 | 8 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 390 | 8 | 1 | 6 | 2.3 | O=C(Cc1ccccc1)NCC(=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| CHEMBL1534477 | 99463 | 8 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 390 | 8 | 1 | 6 | 2.3 | O=C(Cc1ccccc1)NCC(=O)OCC(=O)c1ccc(Cl)c([N+](=O)[O-])c1 | nan | ||
| 9590742 | 217207 | 2 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 273 | 3 | 1 | 3 | 2.9 | C/C(=N\NC(=O)c1ccccc1Cl)c1ccccn1 | nan | ||
| CHEMBL3189245 | 217207 | 2 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 273 | 3 | 1 | 3 | 2.9 | C/C(=N\NC(=O)c1ccccc1Cl)c1ccccn1 | nan | ||
| 10434876 | 235523 | 0 | None | 7 | 2 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 470 | 10 | 1 | 5 | 6.1 | CCCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| CHEMBL336808 | 235523 | 0 | None | 7 | 2 | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 470 | 10 | 1 | 5 | 6.1 | CCCCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm00078a014 | ||
| 2474590 | 86582 | 3 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 291 | 2 | 1 | 4 | 3.2 | O=C(Nc1nc2c(F)cc(F)cc2s1)c1ccccn1 | nan | ||
| CHEMBL1505604 | 86582 | 3 | None | -1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 291 | 2 | 1 | 4 | 3.2 | O=C(Nc1nc2c(F)cc(F)cc2s1)c1ccccn1 | nan | ||
| 9667523 | 218437 | 11 | None | -3 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 328 | 6 | 1 | 6 | 2.3 | C/C(=N\NC(=O)C(C)Oc1ccc([N+](=O)[O-])cc1)c1ccccn1 | nan | ||
| CHEMBL3210072 | 218437 | 11 | None | -3 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 328 | 6 | 1 | 6 | 2.3 | C/C(=N\NC(=O)C(C)Oc1ccc([N+](=O)[O-])cc1)c1ccccn1 | nan | ||
| 14956770 | 473237 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 480 | 7 | 1 | 9 | 3.7 | O=c1n(-c2ccccc2[N+](=O)[O-])nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL86853 | 473237 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 480 | 7 | 1 | 9 | 3.7 | O=c1n(-c2ccccc2[N+](=O)[O-])nc(C2CC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 14956785 | 473359 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 460 | 9 | 2 | 8 | 2.6 | CCCCc1nn(C(C)C(=O)NC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| CHEMBL87682 | 473359 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 460 | 9 | 2 | 8 | 2.6 | CCCCc1nn(C(C)C(=O)NC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00069a015 | ||
| 1487013 | 105195 | 11 | None | 1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 317 | 3 | 1 | 6 | 1.4 | CNC(=O)c1nnsc1S(=O)(=O)c1ccc(Cl)cc1 | nan | ||
| CHEMBL1586425 | 105195 | 11 | None | 1 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 317 | 3 | 1 | 6 | 1.4 | CNC(=O)c1nnsc1S(=O)(=O)c1ccc(Cl)cc1 | nan | ||
| 5337284 | 98985 | 4 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 342 | 5 | 1 | 3 | 4.5 | Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3ccncc3)cc2)c1 | nan | ||
| CHEMBL1530173 | 98985 | 4 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 342 | 5 | 1 | 3 | 4.5 | Cc1cccc(C(=O)Nc2ccc(C(=O)/C=C/c3ccncc3)cc2)c1 | nan | ||
| 991372 | 116710 | 41 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 382 | 1 | 2 | 5 | 4.5 | CC1(C)CC(=O)C2=C(C1)OC1=C(C(=O)CC(C)(C)C1)C2c1ccc(O)cc1O | nan | ||
| CHEMBL1604546 | 116710 | 41 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 382 | 1 | 2 | 5 | 4.5 | CC1(C)CC(=O)C2=C(C1)OC1=C(C(=O)CC(C)(C)C1)C2c1ccc(O)cc1O | nan | ||
| 135472791 | 46165 | 5 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 277 | 2 | 1 | 4 | 5.0 | Cc1ccc(C)c(N=Nc2ccc(O)c3ncccc23)c1 | nan | ||
| CHEMBL1324011 | 46165 | 5 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 277 | 2 | 1 | 4 | 5.0 | Cc1ccc(C)c(N=Nc2ccc(O)c3ncccc23)c1 | nan | ||
| 788618 | 43854 | 8 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 253 | 4 | 1 | 2 | 3.9 | Cc1ccc(C(=O)CNc2cc(C)ccc2C)cc1 | nan | ||
| CHEMBL1303334 | 43854 | 8 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 253 | 4 | 1 | 2 | 3.9 | Cc1ccc(C(=O)CNc2cc(C)ccc2C)cc1 | nan | ||
| 788408 | 86960 | 10 | None | None | None | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 259 | 4 | 1 | 2 | 3.9 | Cc1ccc(C(=O)CNc2cccc(Cl)c2)cc1 | nan | ||
| CHEMBL1508797 | 86960 | 10 | None | None | None | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 259 | 4 | 1 | 2 | 3.9 | Cc1ccc(C(=O)CNc2cccc(Cl)c2)cc1 | nan | ||
| 6918269 | 198737 | 11 | None | None | None | Human | 10.9 | pKd | = | 10.9 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL275875 | 198737 | 11 | None | None | None | Human | 10.9 | pKd | = | 10.9 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 11527144 | 346775 | 0 | None | None | None | Human | 10.9 | pKd | = | 10.9 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL47177 | 346775 | 0 | None | None | None | Human | 10.9 | pKd | = | 10.9 | Functional | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 133031 | 201002 | 20 | None | None | None | Rabbit | 10.3 | pKd | = | 10.3 | Functional | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL293511 | 201002 | 20 | None | None | None | Rabbit | 10.3 | pKd | = | 10.3 | Functional | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 9887844 | 328199 | 5 | None | None | None | Rabbit | 10.3 | pKd | = | 10.3 | Functional | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL418226 | 328199 | 5 | None | None | None | Rabbit | 10.3 | pKd | = | 10.3 | Functional | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/j.bmc.2010.10.043 | ||
| 9911332 | 97987 | 1 | None | None | None | Rabbit | 10.2 | pKd | = | 10.2 | Functional | ChEMBL | 444 | 7 | 2 | 6 | 4.7 | CCCn1nc(C(C)(C)C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9604383 | ||
| CHEMBL152106 | 97987 | 1 | None | None | None | Rabbit | 10.2 | pKd | = | 10.2 | Functional | ChEMBL | 444 | 7 | 2 | 6 | 4.7 | CCCn1nc(C(C)(C)C)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9604383 | ||
| 132387 | 7872 | 20 | None | None | None | Rabbit | 10.1 | pKd | = | 10.1 | Functional | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(c1ncccc1C(=O)O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.bmc.2010.10.043 | ||
| 3938 | 7872 | 20 | None | None | None | Rabbit | 10.1 | pKd | = | 10.1 | Functional | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(c1ncccc1C(=O)O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL416477 | 7872 | 20 | None | None | None | Rabbit | 10.1 | pKd | = | 10.1 | Functional | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(c1ncccc1C(=O)O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.bmc.2010.10.043 | ||
| 108185 | 3317 | 57 | None | None | None | Rabbit | 10.1 | pKd | = | 10.1 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 586 | 3317 | 57 | None | None | None | Rabbit | 10.1 | pKd | = | 10.1 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL907 | 3317 | 57 | None | None | None | Rabbit | 10.1 | pKd | = | 10.1 | Functional | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 9802561 | 316804 | 27 | None | None | None | Rabbit | 10.0 | pKd | = | 10.0 | Functional | ChEMBL | 426 | 6 | 1 | 6 | 4.6 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CCCC2 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL41194 | 316804 | 27 | None | None | None | Rabbit | 10.0 | pKd | = | 10.0 | Functional | ChEMBL | 426 | 6 | 1 | 6 | 4.6 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CCCC2 | 10.1016/j.bmc.2010.10.043 | ||
| 19890807 | 221032 | 0 | None | None | None | Rabbit | 10.0 | pKd | = | 10 | Functional | ChEMBL | 466 | 8 | 1 | 7 | 5.4 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2nc(OC(C)C)ccc2n1 | 10.1021/jm00070a012 | ||
| CHEMBL327932 | 221032 | 0 | None | None | None | Rabbit | 10.0 | pKd | = | 10 | Functional | ChEMBL | 466 | 8 | 1 | 7 | 5.4 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2nc(OC(C)C)ccc2n1 | 10.1021/jm00070a012 | ||
| 15657904 | 370717 | 3 | None | None | None | Rabbit | 9.9 | pKd | = | 9.9 | Functional | ChEMBL | 415 | 8 | 2 | 7 | 3.4 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL49410 | 370717 | 3 | None | None | None | Rabbit | 9.9 | pKd | = | 9.9 | Functional | ChEMBL | 415 | 8 | 2 | 7 | 3.4 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1016/j.bmc.2010.10.043 | ||
| 19017678 | 350121 | 0 | None | None | None | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 474 | 11 | 2 | 8 | 4.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nnn(CC(C)C)c1C(=O)O | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL45927 | 350121 | 0 | None | None | None | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 474 | 11 | 2 | 8 | 4.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nnn(CC(C)C)c1C(=O)O | 10.1016/j.bmc.2010.10.043 | ||
| 9935096 | 474642 | 1 | None | None | None | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 5.3 | CCCCc1cn([C@@H]2[C@@H](C)CCC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL9599 | 474642 | 1 | None | None | None | Human | 9.3 | pKd | = | 9.3 | Functional | ChEMBL | 485 | 8 | 1 | 7 | 5.3 | CCCCc1cn([C@@H]2[C@@H](C)CCC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | ||
| 44373246 | 332975 | 0 | None | None | None | Rabbit | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 435 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL433895 | 332975 | 0 | None | None | None | Rabbit | 9.2 | pKd | = | 9.2 | Functional | ChEMBL | 435 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL2373017 | 485943 | 0 | None | None | None | Rat | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 987 | 21 | 12 | 14 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCSSCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)O | 10.1021/jm00169a019 | ||
| 9912059 | 368648 | 0 | None | None | None | Rabbit | 9.0 | pKd | = | 9 | Functional | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL48602 | 368648 | 0 | None | None | None | Rabbit | 9.0 | pKd | = | 9 | Functional | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 131654 | 473370 | 11 | None | None | None | Rabbit | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL87778 | 473370 | 11 | None | None | None | Rabbit | 8.9 | pKd | = | 8.9 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 9801006 | 238448 | 0 | None | None | None | Rabbit | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 398 | 6 | 1 | 7 | 3.6 | CCc1nc2c(CC)cn(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)n2n1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL347610 | 238448 | 0 | None | None | None | Rabbit | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 398 | 6 | 1 | 7 | 3.6 | CCc1nc2c(CC)cn(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)n2n1 | 10.1016/j.bmc.2010.10.043 | ||
| 178553 | 238915 | 19 | None | None | None | Rabbit | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 387 | 6 | 1 | 6 | 4.1 | COc1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL352257 | 238915 | 19 | None | None | None | Rabbit | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 387 | 6 | 1 | 6 | 4.1 | COc1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1016/j.bmc.2010.10.043 | ||
| 70682146 | 157989 | 0 | None | None | None | Rabbit | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| CHEMBL2058860 | 157989 | 0 | None | None | None | Rabbit | 8.8 | pKd | = | 8.8 | Functional | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| 46910493 | 157993 | 0 | None | None | None | Rabbit | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 615 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| CHEMBL2058864 | 157993 | 0 | None | None | None | Rabbit | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 615 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| 9931685 | 470871 | 0 | None | None | None | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL85595 | 470871 | 0 | None | None | None | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1016/j.bmc.2010.10.043 | ||
| 131857 | 469183 | 22 | None | None | None | Rabbit | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 383 | 5 | 1 | 4 | 5.0 | Cc1ccnc2c1nc(C1CC1)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL71162 | 469183 | 22 | None | None | None | Rabbit | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 383 | 5 | 1 | 4 | 5.0 | Cc1ccnc2c1nc(C1CC1)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 44438885 | 181770 | 0 | None | None | None | Rabbit | 8.0 | pKd | = | 8 | Functional | ChEMBL | 417 | 8 | 2 | 5 | 4.6 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL239378 | 181770 | 0 | None | None | None | Rabbit | 8.0 | pKd | = | 8 | Functional | ChEMBL | 417 | 8 | 2 | 5 | 4.6 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 2541 | 7891 | 68 | None | None | None | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2007.11.008 | ||
| 6907 | 7891 | 68 | None | None | None | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL1016 | 7891 | 68 | None | None | None | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2007.11.008 | ||
| 10094851 | 45147 | 0 | None | None | None | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 441 | 8 | 2 | 4 | 5.8 | CCCCc1nc2cc(NC(C)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL131365 | 45147 | 0 | None | None | None | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 441 | 8 | 2 | 4 | 5.8 | CCCCc1nc2cc(NC(C)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| 1610 | 7967 | 67 | None | None | None | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.056 | ||
| 3941 | 7967 | 67 | None | None | None | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.056 | ||
| 3961 | 7967 | 67 | None | None | None | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL191 | 7967 | 67 | None | None | None | Rat | 8.0 | pKd | = | 8 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.056 | ||
| 24827770 | 196237 | 0 | None | None | None | Rabbit | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | ||
| CHEMBL259114 | 196237 | 0 | None | None | None | Rabbit | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | ||
| 44438869 | 293044 | 0 | None | None | None | Rabbit | 7.0 | pKd | = | 7 | Functional | ChEMBL | 413 | 5 | 1 | 8 | 3.2 | COC(=O)c1cccc2nc(C)n(Cc3ccc(-n4cccc4-c4nnn[nH]4)cc3)c12 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL392118 | 293044 | 0 | None | None | None | Rabbit | 7.0 | pKd | = | 7 | Functional | ChEMBL | 413 | 5 | 1 | 8 | 3.2 | COC(=O)c1cccc2nc(C)n(Cc3ccc(-n4cccc4-c4nnn[nH]4)cc3)c12 | 10.1016/j.bmcl.2007.02.042 | ||
| 44438900 | 294540 | 0 | None | None | None | Rabbit | 7.0 | pKd | = | 7 | Functional | ChEMBL | 403 | 7 | 2 | 5 | 4.2 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL393305 | 294540 | 0 | None | None | None | Rabbit | 7.0 | pKd | = | 7 | Functional | ChEMBL | 403 | 7 | 2 | 5 | 4.2 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 44570265 | 352323 | 0 | None | None | None | Rat | 7.0 | pKd | = | 7 | Functional | ChEMBL | 519 | 12 | 2 | 5 | 5.9 | CCCCNS(=O)(=O)c1ccc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL465929 | 352323 | 0 | None | None | None | Rat | 7.0 | pKd | = | 7 | Functional | ChEMBL | 519 | 12 | 2 | 5 | 5.9 | CCCCNS(=O)(=O)c1ccc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 19351553 | 237495 | 0 | None | None | None | Rabbit | 7.0 | pKd | = | 7 | Functional | ChEMBL | 389 | 10 | 4 | 6 | 3.1 | CCCCCCC(C(=O)O)n1cnc(NC(=O)c2cccc(O)c2C(=O)O)c1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL341716 | 237495 | 0 | None | None | None | Rabbit | 7.0 | pKd | = | 7 | Functional | ChEMBL | 389 | 10 | 4 | 6 | 3.1 | CCCCCCC(C(=O)O)n1cnc(NC(=O)c2cccc(O)c2C(=O)O)c1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL264230 | 486122 | 0 | None | None | None | Rabbit | 7.0 | pKd | = | 7.0 | Functional | ChEMBL | 1096 | 28 | 13 | 13 | -0.9 | CC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | ||
| CHEMBL384349 | 487636 | 0 | None | None | None | Rabbit | 7.0 | pKd | = | 7.0 | Functional | ChEMBL | 1276 | 42 | 11 | 13 | 5.5 | CCCCCCCCCCCCCCCC(=O)Oc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccc3ccccc3c2)C(=O)O)C(C)C)cc1 | 10.1021/jm9608669 | ||
| 1610 | 7967 | 67 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | ||
| 3941 | 7967 | 67 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | ||
| 3961 | 7967 | 67 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL191 | 7967 | 67 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | ||
| 44438865 | 184168 | 0 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 441 | 7 | 1 | 8 | 3.8 | CCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL245644 | 184168 | 0 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 441 | 7 | 1 | 8 | 3.8 | CCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 1610 | 7967 | 67 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | ||
| 3941 | 7967 | 67 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | ||
| 3961 | 7967 | 67 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | ||
| CHEMBL191 | 7967 | 67 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | ||
| 44570305 | 373411 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 545 | 10 | 2 | 5 | 6.4 | CCCCc1nc2cc(S(=O)(=O)NC3CCCCC3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL517626 | 373411 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 545 | 10 | 2 | 5 | 6.4 | CCCCc1nc2cc(S(=O)(=O)NC3CCCCC3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 1610 | 7967 | 67 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | ||
| 3941 | 7967 | 67 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | ||
| 3961 | 7967 | 67 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | ||
| CHEMBL191 | 7967 | 67 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | ||
| 44348352 | 40415 | 0 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 459 | 8 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL123713 | 40415 | 0 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 459 | 8 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC | 10.1016/j.bmc.2010.10.043 | ||
| 1610 | 7967 | 67 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 3941 | 7967 | 67 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 3961 | 7967 | 67 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL191 | 7967 | 67 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 44570215 | 366887 | 0 | None | None | None | Rat | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 477 | 9 | 2 | 5 | 4.7 | CCCCc1nc2cc(S(=O)(=O)NC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL480018 | 366887 | 0 | None | None | None | Rat | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 477 | 9 | 2 | 5 | 4.7 | CCCCc1nc2cc(S(=O)(=O)NC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 9906367 | 105379 | 0 | None | None | None | Human | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 349 | 4 | 1 | 5 | 3.1 | C[C@H]1CN(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C[C@@H](C)O1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL158794 | 105379 | 0 | None | None | None | Human | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 349 | 4 | 1 | 5 | 3.1 | C[C@H]1CN(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C[C@@H](C)O1 | 10.1016/j.bmc.2010.10.043 | ||
| 44438902 | 333979 | 0 | None | None | None | Rabbit | 5.9 | pKd | = | 5.9 | Functional | ChEMBL | 375 | 5 | 2 | 5 | 3.6 | Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL442251 | 333979 | 0 | None | None | None | Rabbit | 5.9 | pKd | = | 5.9 | Functional | ChEMBL | 375 | 5 | 2 | 5 | 3.6 | Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 46910495 | 157990 | 0 | None | None | None | Rabbit | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 585 | 11 | 2 | 7 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| CHEMBL2058861 | 157990 | 0 | None | None | None | Rabbit | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 585 | 11 | 2 | 7 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| 24828707 | 196294 | 0 | None | None | None | Rabbit | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c2ncccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | ||
| CHEMBL259353 | 196294 | 0 | None | None | None | Rabbit | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c2ncccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | ||
| 44438870 | 182801 | 0 | None | None | None | Rabbit | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 469 | 9 | 1 | 8 | 4.6 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL241685 | 182801 | 0 | None | None | None | Rabbit | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 469 | 9 | 1 | 8 | 4.6 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 10250336 | 42745 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 399 | 7 | 2 | 4 | 5.4 | CCCCc1nc2cc(N)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL128318 | 42745 | 0 | None | None | None | Rat | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 399 | 7 | 2 | 4 | 5.4 | CCCCc1nc2cc(N)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| 53323218 | 123021 | 0 | None | None | None | Guinea pig | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 417 | 7 | 2 | 5 | 4.5 | CCCc1nc2cc(C(=O)OC)[nH]c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL1741079 | 123021 | 0 | None | None | None | Guinea pig | 7.8 | pKd | = | 7.8 | Functional | ChEMBL | 417 | 7 | 2 | 5 | 4.5 | CCCc1nc2cc(C(=O)OC)[nH]c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 25110812 | 352940 | 0 | None | None | None | Rat | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 455 | 9 | 2 | 4 | 6.1 | CCCCc1nc2cc(NC(=O)CC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL471334 | 352940 | 0 | None | None | None | Rat | 7.7 | pKd | = | 7.7 | Functional | ChEMBL | 455 | 9 | 2 | 4 | 6.1 | CCCCc1nc2cc(NC(=O)CC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| 1610 | 7967 | 67 | None | None | None | Rabbit | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | ||
| 3941 | 7967 | 67 | None | None | None | Rabbit | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | ||
| 3961 | 7967 | 67 | None | None | None | Rabbit | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | ||
| CHEMBL191 | 7967 | 67 | None | None | None | Rabbit | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | ||
| 44570214 | 366886 | 0 | None | None | None | Rat | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 463 | 8 | 2 | 5 | 4.4 | CCCCc1nc2cc(S(N)(=O)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL480017 | 366886 | 0 | None | None | None | Rat | 6.7 | pKd | = | 6.7 | Functional | ChEMBL | 463 | 8 | 2 | 5 | 4.4 | CCCCc1nc2cc(S(N)(=O)=O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 9932483 | 474712 | 0 | None | None | None | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL9642 | 474712 | 0 | None | None | None | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | ||
| 9954408 | 474825 | 0 | None | None | None | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 430 | 10 | 1 | 6 | 4.7 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL9714 | 474825 | 0 | None | None | None | Human | 8.7 | pKd | = | 8.7 | Functional | ChEMBL | 430 | 10 | 1 | 6 | 4.7 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 25112615 | 369174 | 0 | None | None | None | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 503 | 9 | 2 | 4 | 7.0 | CCCCc1nc2cc(NC(=O)c3ccccc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL486847 | 369174 | 0 | None | None | None | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 503 | 9 | 2 | 4 | 7.0 | CCCCc1nc2cc(NC(=O)c3ccccc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| 44570306 | 352212 | 0 | None | None | None | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 464 | 8 | 2 | 5 | 5.0 | CCCCc1nc2cc(S(=O)(=O)O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL465097 | 352212 | 0 | None | None | None | Rat | 6.6 | pKd | = | 6.6 | Functional | ChEMBL | 464 | 8 | 2 | 5 | 5.0 | CCCCc1nc2cc(S(=O)(=O)O)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 15224471 | 310852 | 0 | None | None | None | Rabbit | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 441 | 8 | 2 | 7 | 4.1 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL400424 | 310852 | 0 | None | None | None | Rabbit | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 441 | 8 | 2 | 7 | 4.1 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 2541 | 7891 | 68 | None | None | None | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2008.10.056 | ||
| 6907 | 7891 | 68 | None | None | None | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL1016 | 7891 | 68 | None | None | None | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2008.10.056 | ||
| 4110026 | 469805 | 1 | None | None | None | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 384 | 7 | 1 | 3 | 5.8 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL7632 | 469805 | 1 | None | None | None | Rat | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 384 | 7 | 1 | 3 | 5.8 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 57380647 | 142598 | 0 | None | None | None | Rabbit | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
| CHEMBL1945010 | 142598 | 0 | None | None | None | Rabbit | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
| 9823146 | 43217 | 0 | None | None | None | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n(CCCC)n1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL12909 | 43217 | 0 | None | None | None | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n(CCCC)n1 | 10.1016/j.bmc.2010.10.043 | ||
| 1610 | 7967 | 67 | None | None | None | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 3941 | 7967 | 67 | None | None | None | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 3961 | 7967 | 67 | None | None | None | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL191 | 7967 | 67 | None | None | None | Human | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2010.10.043 | ||
| 9801627 | 105293 | 15 | None | None | None | Rabbit | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 409 | 7 | 1 | 6 | 4.7 | CCCCc1nc2cccnc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL158725 | 105293 | 15 | None | None | None | Rabbit | 8.5 | pKd | = | 8.5 | Functional | ChEMBL | 409 | 7 | 1 | 6 | 4.7 | CCCCc1nc2cccnc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 17748251 | 184140 | 0 | None | None | None | Rabbit | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL245444 | 184140 | 0 | None | None | None | Rabbit | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 44570266 | 373893 | 0 | None | None | None | Rat | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 519 | 9 | 2 | 5 | 5.9 | CCCCc1nc2cc(S(=O)(=O)NC(C)(C)C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL518388 | 373893 | 0 | None | None | None | Rat | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 519 | 9 | 2 | 5 | 5.9 | CCCCc1nc2cc(S(=O)(=O)NC(C)(C)C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 9938452 | 236748 | 0 | None | None | None | Rabbit | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 591 | 13 | 2 | 6 | 8.1 | CCCCCc1nc(SCc2ccc(-c3ccccc3C(=O)O)cc2)nn1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL340315 | 236748 | 0 | None | None | None | Rabbit | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 591 | 13 | 2 | 6 | 8.1 | CCCCCc1nc(SCc2ccc(-c3ccccc3C(=O)O)cc2)nn1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 17748251 | 184140 | 0 | None | None | None | Rabbit | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL245444 | 184140 | 0 | None | None | None | Rabbit | 8.4 | pKd | = | 8.4 | Functional | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 44438868 | 182800 | 0 | None | None | None | Rabbit | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 427 | 6 | 1 | 8 | 3.4 | CCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL241684 | 182800 | 0 | None | None | None | Rabbit | 7.5 | pKd | = | 7.5 | Functional | ChEMBL | 427 | 6 | 1 | 8 | 3.4 | CCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 44438901 | 182783 | 0 | None | None | None | Rabbit | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 389 | 6 | 2 | 5 | 3.8 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL241529 | 182783 | 0 | None | None | None | Rabbit | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 389 | 6 | 2 | 5 | 3.8 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 25112616 | 369175 | 0 | None | None | None | Rat | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 537 | 9 | 2 | 4 | 7.7 | CCCCc1nc2cc(NC(=O)c3ccccc3Cl)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL486848 | 369175 | 0 | None | None | None | Rat | 6.5 | pKd | = | 6.5 | Functional | ChEMBL | 537 | 9 | 2 | 4 | 7.7 | CCCCc1nc2cc(NC(=O)c3ccccc3Cl)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL415157 | 488385 | 0 | None | None | None | Rabbit | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 1226 | 42 | 11 | 13 | 4.4 | CCCCCCCCCCCCCCCC(=O)Oc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)C(C)C)cc1 | 10.1021/jm9608669 | ||
| 1610 | 7967 | 67 | None | None | None | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2007.11.008 | ||
| 3941 | 7967 | 67 | None | None | None | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2007.11.008 | ||
| 3961 | 7967 | 67 | None | None | None | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL191 | 7967 | 67 | None | None | None | Rat | 7.4 | pKd | = | 7.4 | Functional | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2007.11.008 | ||
| 25112614 | 374684 | 0 | None | None | None | Rat | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 483 | 11 | 2 | 4 | 6.9 | CCCCC(=O)Nc1ccc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL519564 | 374684 | 0 | None | None | None | Rat | 6.4 | pKd | = | 6.4 | Functional | ChEMBL | 483 | 11 | 2 | 4 | 6.9 | CCCCC(=O)Nc1ccc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| 70686410 | 157988 | 0 | None | None | None | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 555 | 10 | 2 | 6 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| CHEMBL2058859 | 157988 | 0 | None | None | None | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 555 | 10 | 2 | 6 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | ||
| 57380414 | 142773 | 0 | None | None | None | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
| CHEMBL1947131 | 142773 | 0 | None | None | None | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
| 10629796 | 197209 | 0 | None | None | None | Rabbit | 5.3 | pKd | = | 5.3 | Functional | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | ||
| 44339988 | 197209 | 0 | None | None | None | Rabbit | 5.3 | pKd | = | 5.3 | Functional | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | ||
| CHEMBL265681 | 197209 | 0 | None | None | None | Rabbit | 5.3 | pKd | = | 5.3 | Functional | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | ||
| CHEMBL411624 | 197209 | 0 | None | None | None | Rabbit | 5.3 | pKd | = | 5.3 | Functional | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | ||
| 132562 | 199875 | 5 | None | None | None | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL284536 | 199875 | 5 | None | None | None | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/j.bmc.2010.10.043 | ||
| 53325868 | 120396 | 1 | None | None | None | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 515 | 12 | 2 | 6 | 5.8 | CCCCc1nc2cc(OC)cc(C(=O)O)c2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL1668002 | 120396 | 1 | None | None | None | Rabbit | 8.3 | pKd | = | 8.3 | Functional | ChEMBL | 515 | 12 | 2 | 6 | 5.8 | CCCCc1nc2cc(OC)cc(C(=O)O)c2n1Cc1ccc(N(CC)C(C(=O)O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 44438880 | 182782 | 0 | None | None | None | Rabbit | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 427 | 7 | 2 | 7 | 3.7 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL241523 | 182782 | 0 | None | None | None | Rabbit | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 427 | 7 | 2 | 7 | 3.7 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 132706 | 3445 | 23 | None | None | None | Human | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | ||
| 6896 | 3445 | 23 | None | None | None | Human | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL315021 | 3445 | 23 | None | None | None | Human | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | ||
| DB01342 | 3445 | 23 | None | None | None | Human | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | ||
| 57380412 | 142771 | 0 | None | None | None | Rabbit | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
| CHEMBL1947129 | 142771 | 0 | None | None | None | Rabbit | 8.2 | pKd | = | 8.2 | Functional | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | ||
| 44570264 | 373790 | 0 | None | None | None | Rat | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 505 | 10 | 2 | 5 | 5.5 | CCCCc1nc2cc(S(=O)(=O)NC(C)C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL518230 | 373790 | 0 | None | None | None | Rat | 7.2 | pKd | = | 7.2 | Functional | ChEMBL | 505 | 10 | 2 | 5 | 5.5 | CCCCc1nc2cc(S(=O)(=O)NC(C)C)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 25112617 | 370021 | 0 | None | None | None | Rat | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 537 | 9 | 2 | 4 | 7.7 | CCCCc1nc2cc(NC(=O)c3ccc(Cl)cc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL488883 | 370021 | 0 | None | None | None | Rat | 6.2 | pKd | = | 6.2 | Functional | ChEMBL | 537 | 9 | 2 | 4 | 7.7 | CCCCc1nc2cc(NC(=O)c3ccc(Cl)cc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL268804 | 486271 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Functional | ChEMBL | 1038 | 27 | 12 | 12 | -0.1 | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | ||
| 44438872 | 333719 | 0 | None | None | None | Rabbit | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| CHEMBL440051 | 333719 | 0 | None | None | None | Rabbit | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | ||
| 15069306 | 352963 | 0 | None | None | None | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 469 | 10 | 2 | 4 | 6.5 | CCCCc1nc2cc(NC(=O)CCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| CHEMBL471505 | 352963 | 0 | None | None | None | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 469 | 10 | 2 | 4 | 6.5 | CCCCc1nc2cc(NC(=O)CCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2007.11.008 | ||
| 44570217 | 366582 | 0 | None | None | None | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 505 | 11 | 2 | 5 | 5.5 | CCCCc1nc2cc(S(=O)(=O)NCCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL479626 | 366582 | 0 | None | None | None | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 505 | 11 | 2 | 5 | 5.5 | CCCCc1nc2cc(S(=O)(=O)NCCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 44570216 | 373154 | 0 | None | None | None | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 491 | 10 | 2 | 5 | 5.1 | CCCCc1nc2cc(S(=O)(=O)NCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| CHEMBL517230 | 373154 | 0 | None | None | None | Rat | 7.1 | pKd | = | 7.1 | Functional | ChEMBL | 491 | 10 | 2 | 5 | 5.1 | CCCCc1nc2cc(S(=O)(=O)NCC)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2008.10.056 | ||
| 6918269 | 198737 | 11 | None | None | None | Rabbit | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| CHEMBL275875 | 198737 | 11 | None | None | None | Rabbit | 8.0 | pKd | = | 8.0 | Functional | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | ||
| 6917 | 271 | 0 | None | None | None | Human | 7.8 | pA2 | = | 7.8 | Functional | Guide to Pharmacology | 348 | 7 | 1 | 3 | 4.9 | CCCCc1cnc(n1Cc1ccc(cc1)c1ccccc1C)C(=O)O | 22889560 | ||
| 73755250 | 271 | 0 | None | None | None | Human | 7.8 | pA2 | = | 7.8 | Functional | Guide to Pharmacology | 348 | 7 | 1 | 3 | 4.9 | CCCCc1cnc(n1Cc1ccc(cc1)c1ccccc1C)C(=O)O | 22889560 | ||
| 11943 | 8428 | 0 | None | -14 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | Guide to Pharmacology | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | None | ||
| 145925549 | 8428 | 0 | None | -14 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | Guide to Pharmacology | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | None | ||
| 162679549 | 8428 | 0 | None | -14 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | Guide to Pharmacology | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | None | ||
| CHEMBL4438122 | 8428 | 0 | None | -14 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | Guide to Pharmacology | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | None | ||
| 123814 | 870 | 31 | None | None | None | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | 774 | 19 | 8 | 9 | 1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 12006574 | ||
| 5368 | 870 | 31 | None | None | None | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | 774 | 19 | 8 | 9 | 1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 12006574 | ||
| CHEMBL261120 | 870 | 31 | None | None | None | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | 774 | 19 | 8 | 9 | 1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 12006574 | ||
| P01015 | 870 | 31 | None | None | None | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | 774 | 19 | 8 | 9 | 1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 12006574 | ||
| P01019 | 870 | 31 | None | None | None | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | 774 | 19 | 8 | 9 | 1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 12006574 | ||
| P11859 | 870 | 31 | None | None | None | Human | 5.9 | pEC50 | = | 5.9 | Functional | Guide to Pharmacology | 774 | 19 | 8 | 9 | 1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 12006574 | ||
| 6894 | 864 | 0 | None | None | None | Human | 8.2 | pEC50 | = | 8.2 | Functional | Guide to Pharmacology | 1002 | 27 | 12 | 12 | -0.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 21464395 | ||
| 91691124 | 864 | 0 | None | None | None | Human | 8.2 | pEC50 | = | 8.2 | Functional | Guide to Pharmacology | 1002 | 27 | 12 | 12 | -0.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 21464395 | ||
| P01019 | 864 | 0 | None | None | None | Human | 8.2 | pEC50 | = | 8.2 | Functional | Guide to Pharmacology | 1002 | 27 | 12 | 12 | -0.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 21464395 | ||
| 6905 | 7086 | 0 | None | None | None | Rat | 8.8 | pEC50 | = | 8.8 | Functional | Guide to Pharmacology | None | None | None | None | 7499361 | ||||
| 11238823 | 156165 | 50 | None | -2 | 3 | Bovine | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 568 | 9 | 1 | 11 | 4.7 | CCOc1nc2cccc(C(=O)OCc3oc(=O)oc3C)c2n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | None | ||
| 135409642 | 156165 | 50 | None | -2 | 3 | Bovine | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 568 | 9 | 1 | 11 | 4.7 | CCOc1nc2cccc(C(=O)OCc3oc(=O)oc3C)c2n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | None | ||
| 4322 | 156165 | 50 | None | -2 | 3 | Bovine | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 568 | 9 | 1 | 11 | 4.7 | CCOc1nc2cccc(C(=O)OCc3oc(=O)oc3C)c2n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | None | ||
| CHEMBL2028661 | 156165 | 50 | None | -2 | 3 | Bovine | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 568 | 9 | 1 | 11 | 4.7 | CCOc1nc2cccc(C(=O)OCc3oc(=O)oc3C)c2n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | None | ||
| DB08822 | 156165 | 50 | None | -2 | 3 | Bovine | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 568 | 9 | 1 | 11 | 4.7 | CCOc1nc2cccc(C(=O)OCc3oc(=O)oc3C)c2n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | None | ||
| 2540 | 18749 | 72 | None | 1 | 3 | Bovine | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | ||
| 475 | 18749 | 72 | None | 1 | 3 | Bovine | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | ||
| CHEMBL1014 | 18749 | 72 | None | 1 | 3 | Bovine | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | ||
| DB00796 | 18749 | 72 | None | 1 | 3 | Bovine | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | ||
| 3839 | 8193 | 57 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | None | ||
| 60919 | 8193 | 57 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | None | ||
| 6898 | 8193 | 57 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | None | ||
| CHEMBL432162 | 8193 | 57 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | None | ||
| DB01349 | 8193 | 57 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | None | ||
| 130881 | 5949 | 68 | None | -1 | 2 | Bovine | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| 1985 | 5949 | 68 | None | -1 | 2 | Bovine | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| 591 | 5949 | 68 | None | -1 | 2 | Bovine | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| CHEMBL1200692 | 5949 | 68 | None | -1 | 2 | Bovine | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| DB00275 | 5949 | 68 | None | -1 | 2 | Bovine | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| 130881 | 5949 | 68 | None | 1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| 1985 | 5949 | 68 | None | 1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| 591 | 5949 | 68 | None | 1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| CHEMBL1200692 | 5949 | 68 | None | 1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| DB00275 | 5949 | 68 | None | 1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | None | ||
| 11238823 | 156165 | 50 | None | -3 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 568 | 9 | 1 | 11 | 4.7 | CCOc1nc2cccc(C(=O)OCc3oc(=O)oc3C)c2n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | None | ||
| 135409642 | 156165 | 50 | None | -3 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 568 | 9 | 1 | 11 | 4.7 | CCOc1nc2cccc(C(=O)OCc3oc(=O)oc3C)c2n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | None | ||
| 4322 | 156165 | 50 | None | -3 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 568 | 9 | 1 | 11 | 4.7 | CCOc1nc2cccc(C(=O)OCc3oc(=O)oc3C)c2n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | None | ||
| CHEMBL2028661 | 156165 | 50 | None | -3 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 568 | 9 | 1 | 11 | 4.7 | CCOc1nc2cccc(C(=O)OCc3oc(=O)oc3C)c2n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | None | ||
| DB08822 | 156165 | 50 | None | -3 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 568 | 9 | 1 | 11 | 4.7 | CCOc1nc2cccc(C(=O)OCc3oc(=O)oc3C)c2n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | None | ||
| 172198 | 866 | 40 | None | -3 | 3 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | ||
| 2504 | 866 | 40 | None | -3 | 3 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | ||
| 5272 | 866 | 40 | None | -3 | 3 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | ||
| CHEMBL408403 | 866 | 40 | None | -3 | 3 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | ||
| DB11842 | 866 | 40 | None | -3 | 3 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | ||
| P01015 | 866 | 40 | None | -3 | 3 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | ||
| P01019 | 866 | 40 | None | -3 | 3 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | ||
| P11859 | 866 | 40 | None | -3 | 3 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | ||
| 4906 | 143124 | 59 | None | -15 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | None | ||
| 9870652 | 143124 | 59 | None | -15 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | None | ||
| CHEMBL1951143 | 143124 | 59 | None | -15 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | None | ||
| DB09279 | 143124 | 59 | None | -15 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 501 | 9 | 1 | 7 | 4.2 | CCCCc1nc(C)c(CC(=S)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | None | ||
| 1610 | 4782 | 0 | None | -1 | 5 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
| 3961 | 4782 | 0 | None | -1 | 5 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
| 590 | 4782 | 0 | None | -1 | 5 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
| CHEMBL191 | 4782 | 0 | None | -1 | 5 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
| DB00678 | 4782 | 0 | None | -1 | 5 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | ||
| 3936 | 4506 | 37 | None | -1 | 3 | Human | 7.9 | pIC50 | = | 7.9 | Functional | Guide to Pharmacology | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 7829475 | ||
| 6603900 | 4506 | 37 | None | -1 | 3 | Human | 7.9 | pIC50 | = | 7.9 | Functional | Guide to Pharmacology | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 7829475 | ||
| CHEMBL288174 | 4506 | 37 | None | -1 | 3 | Human | 7.9 | pIC50 | = | 7.9 | Functional | Guide to Pharmacology | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 7829475 | ||
| 6895 | 4508 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Functional | Guide to Pharmacology | 580 | 9 | 1 | 6 | 6.6 | CCc1nc2c(n1Cc1ccc(cc1)c1cc(ccc1S(=O)(=O)NC(=O)c1ccccc1)CC(C)C)nc(cc2C)C | 9383393 | ||
| 73755245 | 4508 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Functional | Guide to Pharmacology | 580 | 9 | 1 | 6 | 6.6 | CCc1nc2c(n1Cc1ccc(cc1)c1cc(ccc1S(=O)(=O)NC(=O)c1ccccc1)CC(C)C)nc(cc2C)C | 9383393 | ||
| 1610 | 4782 | 0 | None | -1 | 5 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 26315714 | ||
| 1610 | 4782 | 0 | None | -1 | 5 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8372104 | ||
| 3961 | 4782 | 0 | None | -1 | 5 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 26315714 | ||
| 3961 | 4782 | 0 | None | -1 | 5 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8372104 | ||
| 590 | 4782 | 0 | None | -1 | 5 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 26315714 | ||
| 590 | 4782 | 0 | None | -1 | 5 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8372104 | ||
| CHEMBL191 | 4782 | 0 | None | -1 | 5 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 26315714 | ||
| CHEMBL191 | 4782 | 0 | None | -1 | 5 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8372104 | ||
| DB00678 | 4782 | 0 | None | -1 | 5 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 26315714 | ||
| DB00678 | 4782 | 0 | None | -1 | 5 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8372104 | ||
| 6911 | 5790 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 714 | 11 | 0 | 10 | 2.6 | CCCCc1n([c+]nc1Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na])Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na].[Br-] | 23376252 | ||
| 73755247 | 5790 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 714 | 11 | 0 | 10 | 2.6 | CCCCc1n([c+]nc1Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na])Cc1ccc(cc1)c1ccccc1c1nnn(n1)[Na].[Br-] | 23376252 | ||
| 130881 | 5949 | 68 | None | 1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 11451212 | ||
| 1985 | 5949 | 68 | None | 1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 11451212 | ||
| 591 | 5949 | 68 | None | 1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 11451212 | ||
| CHEMBL1200692 | 5949 | 68 | None | 1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 11451212 | ||
| DB00275 | 5949 | 68 | None | 1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 11451212 | ||
| 135415867 | 1158 | 71 | None | 53 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 24739538 | ||
| 135415867 | 1158 | 71 | None | 53 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 24742498 | ||
| 6901 | 1158 | 71 | None | 53 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 24739538 | ||
| 6901 | 1158 | 71 | None | 53 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 24742498 | ||
| CHEMBL57242 | 1158 | 71 | None | 53 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 24739538 | ||
| CHEMBL57242 | 1158 | 71 | None | 53 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | Guide to Pharmacology | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 24742498 | ||
| 10416728 | 4894 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 642 | 14 | 4 | 9 | 3.7 | CCCCCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O | 11303957 | ||
| 6909 | 4894 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 642 | 14 | 4 | 9 | 3.7 | CCCCCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O | 11303957 | ||
| 6910 | 4894 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 642 | 14 | 4 | 9 | 3.7 | CCCCCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O | 11303957 | ||
| 73755246 | 4894 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 642 | 14 | 4 | 9 | 3.7 | CCCCCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O | 11303957 | ||
| CHEMBL344662 | 4894 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 642 | 14 | 4 | 9 | 3.7 | CCCCCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O | 11303957 | ||
| 10416728 | 4894 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 642 | 14 | 4 | 9 | 3.7 | CCCCCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O | 11303957 | ||
| 6909 | 4894 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 642 | 14 | 4 | 9 | 3.7 | CCCCCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O | 11303957 | ||
| 6910 | 4894 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 642 | 14 | 4 | 9 | 3.7 | CCCCCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O | 11303957 | ||
| 73755246 | 4894 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 642 | 14 | 4 | 9 | 3.7 | CCCCCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O | 11303957 | ||
| CHEMBL344662 | 4894 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Functional | Guide to Pharmacology | 642 | 14 | 4 | 9 | 3.7 | CCCCCC[C@@H](C(=O)N1C[C@H](C[C@H]1C(=O)O)Oc1ccc(cc1)C(=O)O)n1cnc(c1)NC(=O)c1ccccc1S(=O)(=O)O | 11303957 | ||
| 132706 | 3445 | 23 | None | 1 | 2 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 7505365 | ||
| 6896 | 3445 | 23 | None | 1 | 2 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 7505365 | ||
| CHEMBL315021 | 3445 | 23 | None | 1 | 2 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 7505365 | ||
| DB01342 | 3445 | 23 | None | 1 | 2 | Rat | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 7505365 | ||
| 2583 | 8231 | 75 | None | -2 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 9878991 | ||
| 592 | 8231 | 75 | None | -2 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 9878991 | ||
| 65999 | 8231 | 75 | None | -2 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 9878991 | ||
| CHEMBL1017 | 8231 | 75 | None | -2 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 9878991 | ||
| DB00966 | 8231 | 75 | None | -2 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 9878991 | ||
| 4673492 | 8951 | 9 | None | -6 | 2 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 8576904 | ||
| 8324 | 8951 | 9 | None | -6 | 2 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 8576904 | ||
| CHEMBL159096 | 8951 | 9 | None | -6 | 2 | Guinea pig | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 8576904 | ||
| 108185 | 3317 | 57 | None | 3 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10193788 | ||
| 108185 | 3317 | 57 | None | 3 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 8372104 | ||
| 586 | 3317 | 57 | None | 3 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10193788 | ||
| 586 | 3317 | 57 | None | 3 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 8372104 | ||
| CHEMBL907 | 3317 | 57 | None | 3 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10193788 | ||
| CHEMBL907 | 3317 | 57 | None | 3 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 8372104 | ||
| 44299731 | 868 | 0 | None | -2 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 884 | 24 | 12 | 12 | -2.4 | NC(=NCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)O)Cc1[nH]cnc1)C(C)C)Cc1ccc(cc1)O)C(C)C)NC(=O)[C@H](CC(=O)O)N)N | 26315714 | ||
| 585 | 868 | 0 | None | -2 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 884 | 24 | 12 | 12 | -2.4 | NC(=NCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)O)Cc1[nH]cnc1)C(C)C)Cc1ccc(cc1)O)C(C)C)NC(=O)[C@H](CC(=O)O)N)N | 26315714 | ||
| CHEMBL56448 | 868 | 0 | None | -2 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 884 | 24 | 12 | 12 | -2.4 | NC(=NCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)O)Cc1[nH]cnc1)C(C)C)Cc1ccc(cc1)O)C(C)C)NC(=O)[C@H](CC(=O)O)N)N | 26315714 | ||
| P01015 | 868 | 0 | None | -2 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 884 | 24 | 12 | 12 | -2.4 | NC(=NCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)O)Cc1[nH]cnc1)C(C)C)Cc1ccc(cc1)O)C(C)C)NC(=O)[C@H](CC(=O)O)N)N | 26315714 | ||
| P01019 | 868 | 0 | None | -2 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 884 | 24 | 12 | 12 | -2.4 | NC(=NCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)O)Cc1[nH]cnc1)C(C)C)Cc1ccc(cc1)O)C(C)C)NC(=O)[C@H](CC(=O)O)N)N | 26315714 | ||
| P11859 | 868 | 0 | None | -2 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 884 | 24 | 12 | 12 | -2.4 | NC(=NCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)O)Cc1[nH]cnc1)C(C)C)Cc1ccc(cc1)O)C(C)C)NC(=O)[C@H](CC(=O)O)N)N | 26315714 | ||
| 6917 | 271 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 348 | 7 | 1 | 3 | 4.9 | CCCCc1cnc(n1Cc1ccc(cc1)c1ccccc1C)C(=O)O | 22889560 | ||
| 73755250 | 271 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Functional | Guide to Pharmacology | 348 | 7 | 1 | 3 | 4.9 | CCCCc1cnc(n1Cc1ccc(cc1)c1ccccc1C)C(=O)O | 22889560 | ||
| 1037 | 3247 | 0 | None | 1 | 2 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 1309870 | ||
| 5281037 | 3247 | 0 | None | 1 | 2 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 1309870 | ||
| 588 | 3247 | 0 | None | 1 | 2 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 1309870 | ||
| CHEMBL813 | 3247 | 0 | None | 1 | 2 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 1309870 | ||
| DB00876 | 3247 | 0 | None | 1 | 2 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 1309870 | ||
| 24755620 | 8610 | 72 | None | -10 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8577935 | ||
| 2806 | 8610 | 72 | None | -10 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8577935 | ||
| 3937 | 8610 | 72 | None | -10 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8577935 | ||
| 5284633 | 8610 | 72 | None | -10 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8577935 | ||
| 60846 | 8610 | 72 | None | -10 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8577935 | ||
| CHEMBL1069 | 8610 | 72 | None | -10 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8577935 | ||
| CHEMBL115622 | 8610 | 72 | None | -10 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8577935 | ||
| CHEMBL5315276 | 8610 | 72 | None | -10 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8577935 | ||
| DB00177 | 8610 | 72 | None | -10 | 3 | Human | 8.6 | pIC50 | = | 8.6 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8577935 | ||
| 1481 | 4225 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10193788 | ||
| 3749 | 4225 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10193788 | ||
| 589 | 4225 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10193788 | ||
| CHEMBL1513 | 4225 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10193788 | ||
| DB01029 | 4225 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10193788 | ||
| 136218976 | 307 | 0 | None | None | None | Rat | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 423 | 9 | 2 | 5 | 3.7 | CCC[C@H](N(C(=O)CC)Cc1ccc(cc1)c1ccccc1c1noc(=O)[nH]1)C(=O)O | 22410249 | ||
| 6913 | 307 | 0 | None | None | None | Rat | 8.8 | pIC50 | = | 8.8 | Functional | Guide to Pharmacology | 423 | 9 | 2 | 5 | 3.7 | CCC[C@H](N(C(=O)CC)Cc1ccc(cc1)c1ccccc1c1noc(=O)[nH]1)C(=O)O | 22410249 | ||
| 2806 | 8083 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 11206708 | ||
| 593 | 8083 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 11206708 | ||
| 60846 | 8083 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 11206708 | ||
| CHEMBL1069 | 8083 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 11206708 | ||
| 3839 | 8193 | 57 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 11046101 | ||
| 60919 | 8193 | 57 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 11046101 | ||
| 6898 | 8193 | 57 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 11046101 | ||
| CHEMBL432162 | 8193 | 57 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 11046101 | ||
| DB01349 | 8193 | 57 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Functional | Guide to Pharmacology | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 11046101 | ||
| 172198 | 866 | 40 | None | -3 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10193788 | ||
| 172198 | 866 | 40 | None | -3 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 26315714 | ||
| 2504 | 866 | 40 | None | -3 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10193788 | ||
| 2504 | 866 | 40 | None | -3 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 26315714 | ||
| 5272 | 866 | 40 | None | -3 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10193788 | ||
| 5272 | 866 | 40 | None | -3 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 26315714 | ||
| CHEMBL408403 | 866 | 40 | None | -3 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10193788 | ||
| CHEMBL408403 | 866 | 40 | None | -3 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 26315714 | ||
| DB11842 | 866 | 40 | None | -3 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10193788 | ||
| DB11842 | 866 | 40 | None | -3 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 26315714 | ||
| P01015 | 866 | 40 | None | -3 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10193788 | ||
| P01015 | 866 | 40 | None | -3 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 26315714 | ||
| P01019 | 866 | 40 | None | -3 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10193788 | ||
| P01019 | 866 | 40 | None | -3 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 26315714 | ||
| P11859 | 866 | 40 | None | -3 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10193788 | ||
| P11859 | 866 | 40 | None | -3 | 3 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 26315714 | ||
| 6894 | 864 | 0 | None | -2 | 2 | Rat | 9.5 | pIC50 | = | 9.5 | Functional | Guide to Pharmacology | 1002 | 27 | 12 | 12 | -0.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 17138938 | ||
| 91691124 | 864 | 0 | None | -2 | 2 | Rat | 9.5 | pIC50 | = | 9.5 | Functional | Guide to Pharmacology | 1002 | 27 | 12 | 12 | -0.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 17138938 | ||
| P01019 | 864 | 0 | None | -2 | 2 | Rat | 9.5 | pIC50 | = | 9.5 | Functional | Guide to Pharmacology | 1002 | 27 | 12 | 12 | -0.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 17138938 | ||
| 2541 | 1626 | 0 | None | None | None | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10193788 | ||
| 587 | 1626 | 0 | None | None | None | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10193788 | ||
| CHEMBL1016 | 1626 | 0 | None | None | None | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10193788 | ||
| DB00796 | 1626 | 0 | None | None | None | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10193788 | ||
| DB13919 | 1626 | 0 | None | None | None | Human | 9.6 | pIC50 | = | 9.6 | Functional | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10193788 | ||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Similar- ity |
Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
Assay Type |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 2541 | 7891 | 68 | None | None | None | Human | 9.4 | pAC50 | = | 9.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| 6907 | 7891 | 68 | None | None | None | Human | 9.4 | pAC50 | = | 9.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1016 | 7891 | 68 | None | None | None | Human | 9.4 | pAC50 | = | 9.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| 158781 | 97454 | 64 | None | None | None | Human | 9.4 | pAC50 | = | 9.4 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1516 | 97454 | 64 | None | None | None | Human | 9.4 | pAC50 | = | 9.4 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1038/s41467-023-40064-9 | |||
| DB00275 | 97454 | 64 | None | None | None | Human | 9.4 | pAC50 | = | 9.4 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 2541 | 7891 | 68 | None | None | None | Human | 9.3 | pAC50 | = | 9.3 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| 6907 | 7891 | 68 | None | None | None | Human | 9.3 | pAC50 | = | 9.3 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1016 | 7891 | 68 | None | None | None | Human | 9.3 | pAC50 | = | 9.3 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1038/s41467-023-40064-9 | |||
| 1481 | 7955 | 73 | None | None | None | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 3749 | 7955 | 73 | None | None | None | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 6908 | 7955 | 73 | None | None | None | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1513 | 7955 | 73 | None | None | None | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 158781 | 97454 | 64 | None | None | None | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1516 | 97454 | 64 | None | None | None | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1038/s41467-023-40064-9 | |||
| DB00275 | 97454 | 64 | None | None | None | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 130881 | 5949 | 68 | None | None | None | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| 1985 | 5949 | 68 | None | None | None | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| 591 | 5949 | 68 | None | None | None | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1200692 | 5949 | 68 | None | None | None | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| DB00275 | 5949 | 68 | None | None | None | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| 1481 | 7955 | 73 | None | None | None | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 3749 | 7955 | 73 | None | None | None | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 6908 | 7955 | 73 | None | None | None | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1513 | 7955 | 73 | None | None | None | Human | 9.1 | pAC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 2583 | 8231 | 75 | None | None | None | Human | 9.0 | pAC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1038/s41467-023-40064-9 | |||
| 592 | 8231 | 75 | None | None | None | Human | 9.0 | pAC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1038/s41467-023-40064-9 | |||
| 65999 | 8231 | 75 | None | None | None | Human | 9.0 | pAC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1017 | 8231 | 75 | None | None | None | Human | 9.0 | pAC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1038/s41467-023-40064-9 | |||
| DB00966 | 8231 | 75 | None | None | None | Human | 9.0 | pAC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1038/s41467-023-40064-9 | |||
| 130881 | 5949 | 68 | None | None | None | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| 1985 | 5949 | 68 | None | None | None | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| 591 | 5949 | 68 | None | None | None | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1200692 | 5949 | 68 | None | None | None | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| DB00275 | 5949 | 68 | None | None | None | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 558 | 10 | 2 | 11 | 4.2 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)C(=O)OCc1oc(=O)oc1C)C(O)(C)C | 10.1038/s41467-023-40064-9 | |||
| 1481 | 7955 | 73 | None | None | None | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 3749 | 7955 | 73 | None | None | None | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 6908 | 7955 | 73 | None | None | None | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1513 | 7955 | 73 | None | None | None | Human | 8.8 | pAC50 | = | 8.8 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1038/s41467-023-40064-9 | |||
| 1037 | 7928 | 51 | None | None | None | Human | 8.7 | pAC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 3940 | 7928 | 51 | None | None | None | Human | 8.7 | pAC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 5281037 | 7928 | 51 | None | None | None | Human | 8.7 | pAC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL813 | 7928 | 51 | None | None | None | Human | 8.7 | pAC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 242 | 971 | 74 | None | None | None | Human | 6.0 | pAC50 | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1038/s41467-023-40064-9 | |||
| 34 | 971 | 74 | None | None | None | Human | 6.0 | pAC50 | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1038/s41467-023-40064-9 | |||
| 60795 | 971 | 74 | None | None | None | Human | 6.0 | pAC50 | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1112 | 971 | 74 | None | None | None | Human | 6.0 | pAC50 | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1038/s41467-023-40064-9 | |||
| DB01238 | 971 | 74 | None | None | None | Human | 6.0 | pAC50 | = | 6 | Binding | ChEMBL | 447 | 7 | 1 | 4 | 4.9 | O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl | 10.1038/s41467-023-40064-9 | |||
| 216239 | 47615 | 74 | None | None | None | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 464 | 5 | 3 | 4 | 5.6 | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 | 10.1038/s41467-023-40064-9 | |||
| 2459 | 47615 | 74 | None | None | None | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 464 | 5 | 3 | 4 | 5.6 | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1336 | 47615 | 74 | None | None | None | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 464 | 5 | 3 | 4 | 5.6 | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 | 10.1038/s41467-023-40064-9 | |||
| DB00398 | 47615 | 74 | None | None | None | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 464 | 5 | 3 | 4 | 5.6 | CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1 | 10.1038/s41467-023-40064-9 | |||
| 25025298 | 159796 | 46 | None | None | None | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 574 | 9 | 2 | 9 | 5.0 | CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 25181577 | 159796 | 46 | None | None | None | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 574 | 9 | 2 | 9 | 5.0 | CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL2105695 | 159796 | 46 | None | None | None | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 574 | 9 | 2 | 9 | 5.0 | CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| DB12095 | 159796 | 46 | None | None | None | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 574 | 9 | 2 | 9 | 5.0 | CCOC(=O)[C@@H](N)Cc1ccc(-c2cc(O[C@H](c3ccc(Cl)cc3-n3ccc(C)n3)C(F)(F)F)nc(N)n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 54682461 | 175643 | 46 | None | None | None | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 602 | 11 | 2 | 6 | 7.3 | CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL222559 | 175643 | 46 | None | None | None | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 602 | 11 | 2 | 6 | 7.3 | CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1 | 10.1038/s41467-023-40064-9 | |||
| DB00932 | 175643 | 46 | None | None | None | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 602 | 11 | 2 | 6 | 7.3 | CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1 | 10.1038/s41467-023-40064-9 | |||
| 441290 | 38389 | 20 | None | None | None | Human | 5.9 | pAC50 | = | 5.9 | Binding | ChEMBL | 529 | 5 | 1 | 5 | 4.4 | C=CC[N+]1([C@H]2C[C@H]3[C@@H]4CC[C@H]5C[C@H](O)[C@@H](N6CCOCC6)C[C@]5(C)[C@H]4CC[C@]3(C)[C@H]2OC(C)=O)CCCC1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1201244 | 38389 | 20 | None | None | None | Human | 5.9 | pAC50 | = | 5.9 | Binding | ChEMBL | 529 | 5 | 1 | 5 | 4.4 | C=CC[N+]1([C@H]2C[C@H]3[C@@H]4CC[C@H]5C[C@H](O)[C@@H](N6CCOCC6)C[C@]5(C)[C@H]4CC[C@]3(C)[C@H]2OC(C)=O)CCCC1 | 10.1038/s41467-023-40064-9 | |||
| DB00728 | 38389 | 20 | None | None | None | Human | 5.9 | pAC50 | = | 5.9 | Binding | ChEMBL | 529 | 5 | 1 | 5 | 4.4 | C=CC[N+]1([C@H]2C[C@H]3[C@@H]4CC[C@H]5C[C@H](O)[C@@H](N6CCOCC6)C[C@]5(C)[C@H]4CC[C@]3(C)[C@H]2OC(C)=O)CCCC1 | 10.1038/s41467-023-40064-9 | |||
| 65948 | 42417 | 69 | None | None | None | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 582 | 9 | 2 | 9 | 4.7 | CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1275868 | 42417 | 69 | None | None | None | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 582 | 9 | 2 | 9 | 4.7 | CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1 | 10.1038/s41467-023-40064-9 | |||
| DB09230 | 42417 | 69 | None | None | None | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 582 | 9 | 2 | 9 | 4.7 | CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC2CN(C(c3ccccc3)c3ccccc3)C2)=C(N)N1 | 10.1038/s41467-023-40064-9 | |||
| 5077 | 7273 | 69 | None | None | None | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 496 | 12 | 1 | 7 | 3.9 | O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| 7552 | 7273 | 69 | None | None | None | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 496 | 12 | 1 | 7 | 3.9 | O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| 9913767 | 7273 | 69 | None | None | None | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 496 | 12 | 1 | 7 | 3.9 | O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL238804 | 7273 | 69 | None | None | None | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 496 | 12 | 1 | 7 | 3.9 | O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| DB11362 | 7273 | 69 | None | None | None | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 496 | 12 | 1 | 7 | 3.9 | O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| 64139 | 175742 | 64 | None | None | None | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 315 | 0 | 1 | 2 | 4.1 | O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL223228 | 175742 | 64 | None | None | None | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 315 | 0 | 1 | 2 | 4.1 | O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 | 10.1038/s41467-023-40064-9 | |||
| DB00625 | 175742 | 64 | None | None | None | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 315 | 0 | 1 | 2 | 4.1 | O=C1Nc2ccc(Cl)cc2[C@@](C#CC2CC2)(C(F)(F)F)O1 | 10.1038/s41467-023-40064-9 | |||
| 2540 | 18749 | 72 | None | None | None | Human | 7.9 | pAC50 | = | 7.9 | Binding | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 475 | 18749 | 72 | None | None | None | Human | 7.9 | pAC50 | = | 7.9 | Binding | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1014 | 18749 | 72 | None | None | None | Human | 7.9 | pAC50 | = | 7.9 | Binding | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| DB00796 | 18749 | 72 | None | None | None | Human | 7.9 | pAC50 | = | 7.9 | Binding | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 180 | 829 | 44 | None | None | None | Human | 5.9 | pAC50 | = | 5.9 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
| 200 | 829 | 44 | None | None | None | Human | 5.9 | pAC50 | = | 5.9 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
| 2160 | 829 | 44 | None | None | None | Human | 5.9 | pAC50 | = | 5.9 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL629 | 829 | 44 | None | None | None | Human | 5.9 | pAC50 | = | 5.9 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
| DB00321 | 829 | 44 | None | None | None | Human | 5.9 | pAC50 | = | 5.9 | Binding | ChEMBL | 277 | 3 | 0 | 1 | 4.2 | CN(CCC=C1c2ccccc2CCc2c1cccc2)C | 10.1038/s41467-023-40064-9 | |||
| 3149 | 26881 | 13 | None | None | None | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 334 | 15 | 0 | 1 | 6.1 | CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1187011 | 26881 | 13 | None | None | None | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 334 | 15 | 0 | 1 | 6.1 | CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| DB11594 | 26881 | 13 | None | None | None | Human | 4.9 | pAC50 | = | 4.9 | Binding | ChEMBL | 334 | 15 | 0 | 1 | 6.1 | CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| 1549120 | 393450 | 55 | None | None | None | Human | 5.8 | pAC50 | = | 5.8 | Binding | ChEMBL | 319 | 4 | 1 | 4 | 2.9 | CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL56337 | 393450 | 55 | None | None | None | Human | 5.8 | pAC50 | = | 5.8 | Binding | ChEMBL | 319 | 4 | 1 | 4 | 2.9 | CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| DB15293 | 393450 | 55 | None | None | None | Human | 5.8 | pAC50 | = | 5.8 | Binding | ChEMBL | 319 | 4 | 1 | 4 | 2.9 | CC(/C=C1\SC(=S)N(CC(=O)O)C1=O)=C\c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| 5281034 | 38338 | 18 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 332 | 0 | 2 | 3 | 4.4 | C[C@]12C/C(=C/O)C(=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1200585 | 38338 | 18 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 332 | 0 | 2 | 3 | 4.4 | C[C@]12C/C(=C/O)C(=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O | 10.1038/s41467-023-40064-9 | |||
| DB06412 | 38338 | 18 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 332 | 0 | 2 | 3 | 4.4 | C[C@]12C/C(=C/O)C(=O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@]2(C)O | 10.1038/s41467-023-40064-9 | |||
| 3599 | 40761 | 62 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 407 | 20 | 0 | 4 | 5.7 | CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL125 | 40761 | 62 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 407 | 20 | 0 | 4 | 5.7 | CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C | 10.1038/s41467-023-40064-9 | |||
| DB09031 | 40761 | 62 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 407 | 20 | 0 | 4 | 5.7 | CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C | 10.1038/s41467-023-40064-9 | |||
| 2767 | 313429 | 63 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 441 | 5 | 2 | 6 | 4.4 | Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 | 10.1038/s41467-023-40064-9 | |||
| 5591 | 313429 | 63 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 441 | 5 | 2 | 6 | 4.4 | Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL408 | 313429 | 63 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 441 | 5 | 2 | 6 | 4.4 | Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 | 10.1038/s41467-023-40064-9 | |||
| DB00197 | 313429 | 63 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 441 | 5 | 2 | 6 | 4.4 | Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2 | 10.1038/s41467-023-40064-9 | |||
| 1150567 | 371619 | 67 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 379 | 6 | 0 | 4 | 4.4 | COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2 | 10.1038/s41467-023-40064-9 | |||
| 3152 | 371619 | 67 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 379 | 6 | 0 | 4 | 4.4 | COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2 | 10.1038/s41467-023-40064-9 | |||
| 946 | 371619 | 67 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 379 | 6 | 0 | 4 | 4.4 | COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL502 | 371619 | 67 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 379 | 6 | 0 | 4 | 4.4 | COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2 | 10.1038/s41467-023-40064-9 | |||
| DB00843 | 371619 | 67 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 379 | 6 | 0 | 4 | 4.4 | COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2 | 10.1038/s41467-023-40064-9 | |||
| DB07701 | 371619 | 67 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 379 | 6 | 0 | 4 | 4.4 | COc1cc2c(cc1OC)C(=O)C(CC1CCN(Cc3ccccc3)CC1)C2 | 10.1038/s41467-023-40064-9 | |||
| 2333 | 279489 | 72 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 422 | 3 | 1 | 3 | 5.5 | CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 | 10.1038/s41467-023-40064-9 | |||
| 318 | 279489 | 72 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 422 | 3 | 1 | 3 | 5.5 | CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL388590 | 279489 | 72 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 422 | 3 | 1 | 3 | 5.5 | CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 | 10.1038/s41467-023-40064-9 | |||
| DB12319 | 279489 | 72 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 422 | 3 | 1 | 3 | 5.5 | CCc1oc2ccccc2c1C(=O)c1cc(Br)c(O)c(Br)c1 | 10.1038/s41467-023-40064-9 | |||
| 5803 | 317723 | 64 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 622 | 4 | 2 | 3 | 4.6 | O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL41632 | 317723 | 64 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 622 | 4 | 2 | 3 | 4.6 | O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1 | 10.1038/s41467-023-40064-9 | |||
| DB03604 | 317723 | 64 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 622 | 4 | 2 | 3 | 4.6 | O=C(O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1 | 10.1038/s41467-023-40064-9 | |||
| 104850 | 6773 | 56 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
| 4150 | 6773 | 56 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
| 743 | 6773 | 56 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL111 | 6773 | 56 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
| DB06155 | 6773 | 56 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 462 | 4 | 1 | 4 | 5.9 | Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1 | 10.1038/s41467-023-40064-9 | |||
| 2540 | 18749 | 72 | None | None | None | Human | 7.8 | pAC50 | = | 7.8 | Binding | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 475 | 18749 | 72 | None | None | None | Human | 7.8 | pAC50 | = | 7.8 | Binding | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1014 | 18749 | 72 | None | None | None | Human | 7.8 | pAC50 | = | 7.8 | Binding | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| DB00796 | 18749 | 72 | None | None | None | Human | 7.8 | pAC50 | = | 7.8 | Binding | ChEMBL | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 5852 | 5328 | 56 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 419 | 11 | 1 | 5 | 4.9 | OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| 9931891 | 5328 | 56 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 419 | 11 | 1 | 5 | 4.9 | OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL239226 | 5328 | 56 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 419 | 11 | 1 | 5 | 4.9 | OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C | 10.1038/s41467-023-40064-9 | |||
| 5318 | 39468 | 43 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 396 | 6 | 0 | 3 | 6.5 | Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1221 | 39468 | 43 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 396 | 6 | 0 | 3 | 6.5 | Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
| DB06820 | 39468 | 43 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 396 | 6 | 0 | 3 | 6.5 | Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
| 1385580 | 62931 | 59 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 4.1 | O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 | 10.1038/s41467-023-40064-9 | |||
| 2014 | 62931 | 59 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 4.1 | O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 | 10.1038/s41467-023-40064-9 | |||
| 4615 | 62931 | 59 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 4.1 | O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL13828 | 62931 | 59 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 4.1 | O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 | 10.1038/s41467-023-40064-9 | |||
| DB12877 | 62931 | 59 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 4.1 | O=c1[nH]c2ccccc2n1CCCN1CCN(C(c2ccccc2)c2ccccc2)CC1 | 10.1038/s41467-023-40064-9 | |||
| 1056 | 6857 | 72 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1038/s41467-023-40064-9 | |||
| 2405 | 6857 | 72 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1038/s41467-023-40064-9 | |||
| 77999 | 6857 | 72 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL121 | 6857 | 72 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1038/s41467-023-40064-9 | |||
| DB00412 | 6857 | 72 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1038/s41467-023-40064-9 | |||
| 40973 | 99309 | 54 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 310 | 1 | 1 | 1 | 4.9 | C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1533 | 99309 | 54 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 310 | 1 | 1 | 1 | 4.9 | C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC | 10.1038/s41467-023-40064-9 | |||
| DB00304 | 99309 | 54 | None | None | None | Human | 4.8 | pAC50 | = | 4.8 | Binding | ChEMBL | 310 | 1 | 1 | 1 | 4.9 | C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC | 10.1038/s41467-023-40064-9 | |||
| 135409453 | 8225 | 26 | None | None | None | Human | 5.8 | pAC50 | = | 5.8 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1038/s41467-023-40064-9 | |||
| 226 | 8225 | 26 | None | None | None | Human | 5.8 | pAC50 | = | 5.8 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1038/s41467-023-40064-9 | |||
| 2579 | 8225 | 26 | None | None | None | Human | 5.8 | pAC50 | = | 5.8 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1038/s41467-023-40064-9 | |||
| 5362436 | 8225 | 26 | None | None | None | Human | 5.8 | pAC50 | = | 5.8 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1038/s41467-023-40064-9 | |||
| CHEMBL76370 | 8225 | 26 | None | None | None | Human | 5.8 | pAC50 | = | 5.8 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1038/s41467-023-40064-9 | |||
| DB01079 | 8225 | 26 | None | None | None | Human | 5.8 | pAC50 | = | 5.8 | Binding | ChEMBL | 301 | 7 | 3 | 3 | 2.6 | CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N | 10.1038/s41467-023-40064-9 | |||
| 3516 | 474969 | 76 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 198 | 5 | 2 | 4 | 0.4 | COc1ccccc1OCC(O)CO | 10.1038/s41467-023-40064-9 | |||
| CHEMBL980 | 474969 | 76 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 198 | 5 | 2 | 4 | 0.4 | COc1ccccc1OCC(O)CO | 10.1038/s41467-023-40064-9 | |||
| DB00874 | 474969 | 76 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 198 | 5 | 2 | 4 | 0.4 | COc1ccccc1OCC(O)CO | 10.1038/s41467-023-40064-9 | |||
| 135398735 | 270475 | 30 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 822 | 4 | 6 | 15 | 4.3 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | |||
| 136262914 | 270475 | 30 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 822 | 4 | 6 | 15 | 4.3 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | |||
| 5381226 | 270475 | 30 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 822 | 4 | 6 | 15 | 4.3 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL374478 | 270475 | 30 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 822 | 4 | 6 | 15 | 4.3 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | |||
| DB01045 | 270475 | 30 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 822 | 4 | 6 | 15 | 4.3 | CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C | 10.1038/s41467-023-40064-9 | |||
| 72093 | 78550 | 5 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 483 | 16 | 1 | 4 | 6.3 | CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1433361 | 78550 | 5 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 483 | 16 | 1 | 4 | 6.3 | CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 | 10.1038/s41467-023-40064-9 | |||
| DB13500 | 78550 | 5 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 483 | 16 | 1 | 4 | 6.3 | CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 | 10.1038/s41467-023-40064-9 | |||
| 4495 | 393509 | 69 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 308 | 5 | 1 | 5 | 2.8 | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL56367 | 393509 | 69 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 308 | 5 | 1 | 5 | 2.8 | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| DB04743 | 393509 | 69 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 308 | 5 | 1 | 5 | 2.8 | CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| 2303 | 6476 | 48 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| 4946 | 6476 | 48 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| 564 | 6476 | 48 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| 63 | 6476 | 48 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| 91536 | 6476 | 48 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL27 | 6476 | 48 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL452861 | 6476 | 48 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| DB00571 | 6476 | 48 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 259 | 6 | 2 | 3 | 2.6 | O[C@H](COc1cccc2c1cccc2)CNC(C)C | 10.1038/s41467-023-40064-9 | |||
| 25025298 | 159727 | 42 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 546 | 8 | 3 | 8 | 4.5 | Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL2103855 | 159727 | 42 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 546 | 8 | 3 | 8 | 4.5 | Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1 | 10.1038/s41467-023-40064-9 | |||
| DB14218 | 159727 | 42 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 546 | 8 | 3 | 8 | 4.5 | Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1 | 10.1038/s41467-023-40064-9 | |||
| 5280453 | 470769 | 51 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 416 | 6 | 3 | 3 | 5.7 | C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL846 | 470769 | 51 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 416 | 6 | 3 | 3 | 5.7 | C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O | 10.1038/s41467-023-40064-9 | |||
| DB00136 | 470769 | 51 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 416 | 6 | 3 | 3 | 5.7 | C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O | 10.1038/s41467-023-40064-9 | |||
| 54454 | 19595 | 56 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 418 | 6 | 1 | 5 | 4.6 | CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1064 | 19595 | 56 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 418 | 6 | 1 | 5 | 4.6 | CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 | 10.1038/s41467-023-40064-9 | |||
| DB00641 | 19595 | 56 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 418 | 6 | 1 | 5 | 4.6 | CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 | 10.1038/s41467-023-40064-9 | |||
| 6540478 | 38360 | 37 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 369 | 2 | 1 | 4 | 4.7 | C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=C/C(=N/O)CC[C@@H]4[C@H]3CC[C@@]21CC | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1200934 | 38360 | 37 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 369 | 2 | 1 | 4 | 4.7 | C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=C/C(=N/O)CC[C@@H]4[C@H]3CC[C@@]21CC | 10.1038/s41467-023-40064-9 | |||
| DB00957 | 38360 | 37 | None | None | None | Human | 4.7 | pAC50 | = | 4.7 | Binding | ChEMBL | 369 | 2 | 1 | 4 | 4.7 | C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=C/C(=N/O)CC[C@@H]4[C@H]3CC[C@@]21CC | 10.1038/s41467-023-40064-9 | |||
| 51755 | 120201 | 39 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 454 | 8 | 0 | 4 | 7.3 | Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1651990 | 120201 | 39 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 454 | 8 | 0 | 4 | 7.3 | Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1 | 10.1038/s41467-023-40064-9 | |||
| DB13434 | 120201 | 39 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 454 | 8 | 0 | 4 | 7.3 | Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1 | 10.1038/s41467-023-40064-9 | |||
| 1353 | 3909 | 69 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
| 3559 | 3909 | 69 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
| 86 | 3909 | 69 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL54 | 3909 | 69 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
| DB00502 | 3909 | 69 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | 10.1038/s41467-023-40064-9 | |||
| 11980903 | 38402 | 12 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 5.3 | Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| 22526 | 38402 | 12 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 5.3 | Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| 5281035 | 38402 | 12 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 5.3 | Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1201303 | 38402 | 12 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 5.3 | Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| DB06816 | 38402 | 12 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 382 | 4 | 0 | 2 | 5.3 | Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 | 10.1038/s41467-023-40064-9 | |||
| 5564 | 470800 | 75 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 288 | 2 | 1 | 2 | 5.1 | Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL849 | 470800 | 75 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 288 | 2 | 1 | 2 | 5.1 | Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl | 10.1038/s41467-023-40064-9 | |||
| DB08604 | 470800 | 75 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 288 | 2 | 1 | 2 | 5.1 | Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl | 10.1038/s41467-023-40064-9 | |||
| 3899 | 474645 | 75 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 270 | 2 | 1 | 3 | 3.3 | Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL960 | 474645 | 75 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 270 | 2 | 1 | 3 | 3.3 | Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 | 10.1038/s41467-023-40064-9 | |||
| DB01097 | 474645 | 75 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 270 | 2 | 1 | 3 | 3.3 | Cc1oncc1C(=O)Nc1ccc(C(F)(F)F)cc1 | 10.1038/s41467-023-40064-9 | |||
| 24826799 | 25079 | 69 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 532 | 4 | 1 | 6 | 4.5 | Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1171837 | 25079 | 69 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 532 | 4 | 1 | 6 | 4.5 | Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 | 10.1038/s41467-023-40064-9 | |||
| DB08901 | 25079 | 69 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 532 | 4 | 1 | 6 | 4.5 | Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12 | 10.1038/s41467-023-40064-9 | |||
| 2335 | 26122 | 15 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 412 | 11 | 0 | 2 | 6.1 | CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 3018 | 26122 | 15 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 412 | 11 | 0 | 2 | 6.1 | CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1182210 | 26122 | 15 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 412 | 11 | 0 | 2 | 6.1 | CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 | 10.1038/s41467-023-40064-9 | |||
| DB11125 | 26122 | 15 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 412 | 11 | 0 | 2 | 6.1 | CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 2585 | 1662 | 62 | None | None | None | Human | 6.6 | pAC50 | = | 6.6 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | 10.1038/s41467-023-40064-9 | |||
| 522 | 1662 | 62 | None | None | None | Human | 6.6 | pAC50 | = | 6.6 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | 10.1038/s41467-023-40064-9 | |||
| 551 | 1662 | 62 | None | None | None | Human | 6.6 | pAC50 | = | 6.6 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL723 | 1662 | 62 | None | None | None | Human | 6.6 | pAC50 | = | 6.6 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | 10.1038/s41467-023-40064-9 | |||
| DB01136 | 1662 | 62 | None | None | None | Human | 6.6 | pAC50 | = | 6.6 | Binding | ChEMBL | 406 | 10 | 3 | 5 | 3.7 | COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O | 10.1038/s41467-023-40064-9 | |||
| 1610 | 7967 | 67 | None | None | None | Human | 7.6 | pAC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3941 | 7967 | 67 | None | None | None | Human | 7.6 | pAC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3961 | 7967 | 67 | None | None | None | Human | 7.6 | pAC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Human | 7.6 | pAC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 16220172 | 145252 | 74 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 392 | 2 | 3 | 3 | 5.1 | CC(C)(C)c1cc(C(C)(C)C)c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL2010601 | 145252 | 74 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 392 | 2 | 3 | 3 | 5.1 | CC(C)(C)c1cc(C(C)(C)C)c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O | 10.1038/s41467-023-40064-9 | |||
| DB08820 | 145252 | 74 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 392 | 2 | 3 | 3 | 5.1 | CC(C)(C)c1cc(C(C)(C)C)c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O | 10.1038/s41467-023-40064-9 | |||
| 3926 | 474146 | 33 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 491 | 9 | 1 | 3 | 5.8 | Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL92870 | 474146 | 33 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 491 | 9 | 1 | 3 | 5.8 | Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1038/s41467-023-40064-9 | |||
| DB13766 | 474146 | 33 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 491 | 9 | 1 | 3 | 5.8 | Cc1cccc(C)c1NC(=O)CN1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 | 10.1038/s41467-023-40064-9 | |||
| 54585 | 38412 | 52 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 357 | 7 | 4 | 6 | 2.7 | O=C(O)CCNC(=O)c1ccc(/N=N/c2ccc(O)c(C(=O)O)c2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 6335412 | 38412 | 52 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 357 | 7 | 4 | 6 | 2.7 | O=C(O)CCNC(=O)c1ccc(/N=N/c2ccc(O)c(C(=O)O)c2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1201346 | 38412 | 52 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 357 | 7 | 4 | 6 | 2.7 | O=C(O)CCNC(=O)c1ccc(/N=N/c2ccc(O)c(C(=O)O)c2)cc1 | 10.1038/s41467-023-40064-9 | |||
| DB01014 | 38412 | 52 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 357 | 7 | 4 | 6 | 2.7 | O=C(O)CCNC(=O)c1ccc(/N=N/c2ccc(O)c(C(=O)O)c2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 2812 | 19119 | 69 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | 10.1038/s41467-023-40064-9 | |||
| 719 | 19119 | 69 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL104 | 19119 | 69 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | 10.1038/s41467-023-40064-9 | |||
| DB00257 | 19119 | 69 | None | None | None | Human | 4.6 | pAC50 | = | 4.6 | Binding | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | 10.1038/s41467-023-40064-9 | |||
| 11626560 | 450637 | 63 | None | None | None | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 449 | 5 | 2 | 6 | 5.0 | C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL601719 | 450637 | 63 | None | None | None | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 449 | 5 | 2 | 6 | 5.0 | C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl | 10.1038/s41467-023-40064-9 | |||
| DB08865 | 450637 | 63 | None | None | None | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 449 | 5 | 2 | 6 | 5.0 | C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl | 10.1038/s41467-023-40064-9 | |||
| 47472 | 43289 | 46 | None | None | None | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 410 | 7 | 0 | 3 | 6.6 | Clc1ccc(CCC(Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1295 | 43289 | 46 | None | None | None | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 410 | 7 | 0 | 3 | 6.6 | Clc1ccc(CCC(Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
| DB00639 | 43289 | 46 | None | None | None | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 410 | 7 | 0 | 3 | 6.6 | Clc1ccc(CCC(Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1 | 10.1038/s41467-023-40064-9 | |||
| 16362 | 6358 | 55 | None | None | None | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
| 2172 | 6358 | 55 | None | None | None | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
| 90 | 6358 | 55 | None | None | None | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1423 | 6358 | 55 | None | None | None | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
| DB01100 | 6358 | 55 | None | None | None | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 461 | 7 | 1 | 3 | 5.9 | Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2 | 10.1038/s41467-023-40064-9 | |||
| 2391 | 6779 | 65 | None | None | None | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 720 | 17 | 4 | 9 | 5.9 | O=C(N[C@H]([C@H](C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)NC(=O)N(Cc1csc(n1)C(C)C)C)O)Cc1ccccc1)OCc1cncs1 | 10.1038/s41467-023-40064-9 | |||
| 392622 | 6779 | 65 | None | None | None | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 720 | 17 | 4 | 9 | 5.9 | O=C(N[C@H]([C@H](C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)NC(=O)N(Cc1csc(n1)C(C)C)C)O)Cc1ccccc1)OCc1cncs1 | 10.1038/s41467-023-40064-9 | |||
| 8804 | 6779 | 65 | None | None | None | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 720 | 17 | 4 | 9 | 5.9 | O=C(N[C@H]([C@H](C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)NC(=O)N(Cc1csc(n1)C(C)C)C)O)Cc1ccccc1)OCc1cncs1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL163 | 6779 | 65 | None | None | None | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 720 | 17 | 4 | 9 | 5.9 | O=C(N[C@H]([C@H](C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)NC(=O)N(Cc1csc(n1)C(C)C)C)O)Cc1ccccc1)OCc1cncs1 | 10.1038/s41467-023-40064-9 | |||
| DB00503 | 6779 | 65 | None | None | None | Human | 4.5 | pAC50 | = | 4.5 | Binding | ChEMBL | 720 | 17 | 4 | 9 | 5.9 | O=C(N[C@H]([C@H](C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)NC(=O)N(Cc1csc(n1)C(C)C)C)O)Cc1ccccc1)OCc1cncs1 | 10.1038/s41467-023-40064-9 | |||
| 1922 | 141633 | 77 | None | None | None | Human | 4.4 | pAC50 | = | 4.4 | Binding | ChEMBL | 346 | 4 | 1 | 7 | 2.2 | COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-] | 10.1038/s41467-023-40064-9 | |||
| 4485 | 141633 | 77 | None | None | None | Human | 4.4 | pAC50 | = | 4.4 | Binding | ChEMBL | 346 | 4 | 1 | 7 | 2.2 | COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-] | 10.1038/s41467-023-40064-9 | |||
| CHEMBL193 | 141633 | 77 | None | None | None | Human | 4.4 | pAC50 | = | 4.4 | Binding | ChEMBL | 346 | 4 | 1 | 7 | 2.2 | COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-] | 10.1038/s41467-023-40064-9 | |||
| DB01115 | 141633 | 77 | None | None | None | Human | 4.4 | pAC50 | = | 4.4 | Binding | ChEMBL | 346 | 4 | 1 | 7 | 2.2 | COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-] | 10.1038/s41467-023-40064-9 | |||
| 1612 | 371819 | 62 | None | None | None | Human | 4.4 | pAC50 | = | 4.4 | Binding | ChEMBL | 404 | 6 | 1 | 5 | 4.2 | CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 | 10.1038/s41467-023-40064-9 | |||
| 53232 | 371819 | 62 | None | None | None | Human | 4.4 | pAC50 | = | 4.4 | Binding | ChEMBL | 404 | 6 | 1 | 5 | 4.2 | CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL503 | 371819 | 62 | None | None | None | Human | 4.4 | pAC50 | = | 4.4 | Binding | ChEMBL | 404 | 6 | 1 | 5 | 4.2 | CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 | 10.1038/s41467-023-40064-9 | |||
| DB00227 | 371819 | 62 | None | None | None | Human | 4.4 | pAC50 | = | 4.4 | Binding | ChEMBL | 404 | 6 | 1 | 5 | 4.2 | CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 | 10.1038/s41467-023-40064-9 | |||
| 1037 | 7928 | 51 | None | None | None | Human | 8.4 | pAC50 | = | 8.4 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 3940 | 7928 | 51 | None | None | None | Human | 8.4 | pAC50 | = | 8.4 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 5281037 | 7928 | 51 | None | None | None | Human | 8.4 | pAC50 | = | 8.4 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL813 | 7928 | 51 | None | None | None | Human | 8.4 | pAC50 | = | 8.4 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 5329102 | 387203 | 55 | None | None | None | Human | 5.4 | pAC50 | = | 5.4 | Binding | ChEMBL | 398 | 7 | 3 | 3 | 3.3 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL535 | 387203 | 55 | None | None | None | Human | 5.4 | pAC50 | = | 5.4 | Binding | ChEMBL | 398 | 7 | 3 | 3 | 3.3 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | 10.1038/s41467-023-40064-9 | |||
| DB01268 | 387203 | 55 | None | None | None | Human | 5.4 | pAC50 | = | 5.4 | Binding | ChEMBL | 398 | 7 | 3 | 3 | 3.3 | CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C | 10.1038/s41467-023-40064-9 | |||
| 1037 | 7928 | 51 | None | None | None | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 3940 | 7928 | 51 | None | None | None | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 5281037 | 7928 | 51 | None | None | None | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL813 | 7928 | 51 | None | None | None | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 1610 | 7967 | 67 | None | None | None | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3941 | 7967 | 67 | None | None | None | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3961 | 7967 | 67 | None | None | None | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 1037 | 7928 | 51 | None | None | None | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 3940 | 7928 | 51 | None | None | None | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 5281037 | 7928 | 51 | None | None | None | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL813 | 7928 | 51 | None | None | None | Human | 8.3 | pAC50 | = | 8.3 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1038/s41467-023-40064-9 | |||
| 2855 | 8939 | 68 | None | None | None | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1038/s41467-023-40064-9 | |||
| 3322 | 8939 | 68 | None | None | None | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1038/s41467-023-40064-9 | |||
| 5717 | 8939 | 68 | None | None | None | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL603 | 8939 | 68 | None | None | None | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1038/s41467-023-40064-9 | |||
| DB00549 | 8939 | 68 | None | None | None | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1038/s41467-023-40064-9 | |||
| 1142 | 83603 | 74 | None | None | None | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 383 | 4 | 1 | 5 | 4.0 | CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(Cl)c1Cl | 10.1038/s41467-023-40064-9 | |||
| 3333 | 83603 | 74 | None | None | None | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 383 | 4 | 1 | 5 | 4.0 | CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(Cl)c1Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1480 | 83603 | 74 | None | None | None | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 383 | 4 | 1 | 5 | 4.0 | CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(Cl)c1Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL3196476 | 83603 | 74 | None | None | None | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 383 | 4 | 1 | 5 | 4.0 | CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(Cl)c1Cl | 10.1038/s41467-023-40064-9 | |||
| DB01023 | 83603 | 74 | None | None | None | Human | 4.3 | pAC50 | = | 4.3 | Binding | ChEMBL | 383 | 4 | 1 | 5 | 4.0 | CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(Cl)c1Cl | 10.1038/s41467-023-40064-9 | |||
| 41684 | 64851 | 70 | None | None | None | Human | 5.3 | pAC50 | = | 5.3 | Binding | ChEMBL | 307 | 4 | 1 | 7 | 2.2 | CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1401 | 64851 | 70 | None | None | None | Human | 5.3 | pAC50 | = | 5.3 | Binding | ChEMBL | 307 | 4 | 1 | 7 | 2.2 | CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 | 10.1038/s41467-023-40064-9 | |||
| DB00507 | 64851 | 70 | None | None | None | Human | 5.3 | pAC50 | = | 5.3 | Binding | ChEMBL | 307 | 4 | 1 | 7 | 2.2 | CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 | 10.1038/s41467-023-40064-9 | |||
| 146015366 | 475220 | 47 | None | None | None | Human | 5.2 | pAC50 | = | 5.2 | Binding | ChEMBL | 319 | 9 | 5 | 4 | 0.5 | CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O | 10.1038/s41467-023-40064-9 | |||
| 60852 | 475220 | 47 | None | None | None | Human | 5.2 | pAC50 | = | 5.2 | Binding | ChEMBL | 319 | 9 | 5 | 4 | 0.5 | CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL997 | 475220 | 47 | None | None | None | Human | 5.2 | pAC50 | = | 5.2 | Binding | ChEMBL | 319 | 9 | 5 | 4 | 0.5 | CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O | 10.1038/s41467-023-40064-9 | |||
| DB00710 | 475220 | 47 | None | None | None | Human | 5.2 | pAC50 | = | 5.2 | Binding | ChEMBL | 319 | 9 | 5 | 4 | 0.5 | CCCCCN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O | 10.1038/s41467-023-40064-9 | |||
| 275196 | 251180 | 36 | None | None | None | Human | 6.2 | pAC50 | = | 6.2 | Binding | ChEMBL | 413 | 4 | 0 | 8 | 2.9 | COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C | 10.1038/s41467-023-40064-9 | |||
| CHEMBL364713 | 251180 | 36 | None | None | None | Human | 6.2 | pAC50 | = | 6.2 | Binding | ChEMBL | 413 | 4 | 0 | 8 | 2.9 | COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C | 10.1038/s41467-023-40064-9 | |||
| DB06174 | 251180 | 36 | None | None | None | Human | 6.2 | pAC50 | = | 6.2 | Binding | ChEMBL | 413 | 4 | 0 | 8 | 2.9 | COc1ccc2c(c1OC)C(=O)O[C@@H]2[C@H]1c2c(cc3c(c2OC)OCO3)CCN1C | 10.1038/s41467-023-40064-9 | |||
| 4494 | 373282 | 59 | None | None | None | Human | 4.2 | pAC50 | = | 4.2 | Binding | ChEMBL | 385 | 5 | 1 | 8 | 2.5 | COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL517427 | 373282 | 59 | None | None | None | Human | 4.2 | pAC50 | = | 4.2 | Binding | ChEMBL | 385 | 5 | 1 | 8 | 2.5 | COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1 | 10.1038/s41467-023-40064-9 | |||
| DB06712 | 373282 | 59 | None | None | None | Human | 4.2 | pAC50 | = | 4.2 | Binding | ChEMBL | 385 | 5 | 1 | 8 | 2.5 | COC(=O)C1=C(C#N)NC(C)=C(C(=O)OC(C)C)C1c1cccc([N+](=O)[O-])c1 | 10.1038/s41467-023-40064-9 | |||
| 5282219 | 79340 | 49 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 450 | 12 | 1 | 5 | 5.7 | CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1441961 | 79340 | 49 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 450 | 12 | 1 | 5 | 5.7 | CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1 | 10.1038/s41467-023-40064-9 | |||
| DB05197 | 79340 | 49 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 450 | 12 | 1 | 5 | 5.7 | CC(C)=CCOc1ccc(/C=C/C(=O)c2ccc(OCC=C(C)C)cc2OCC(=O)O)cc1 | 10.1038/s41467-023-40064-9 | |||
| 135565674 | 387474 | 64 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 627 | 15 | 3 | 10 | 5.8 | CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 | 10.1038/s41467-023-40064-9 | |||
| 213023 | 387474 | 64 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 627 | 15 | 3 | 10 | 5.8 | CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 | 10.1038/s41467-023-40064-9 | |||
| 6445226 | 387474 | 64 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 627 | 15 | 3 | 10 | 5.8 | CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 | 10.1038/s41467-023-40064-9 | |||
| 9578572 | 387474 | 64 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 627 | 15 | 3 | 10 | 5.8 | CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL539697 | 387474 | 64 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 627 | 15 | 3 | 10 | 5.8 | CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 | 10.1038/s41467-023-40064-9 | |||
| DB06695 | 387474 | 64 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 627 | 15 | 3 | 10 | 5.8 | CCCCCCOC(=O)NC(=N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1 | 10.1038/s41467-023-40064-9 | |||
| 4209 | 8026 | 58 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | 10.1038/s41467-023-40064-9 | |||
| 4893 | 8026 | 58 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | 10.1038/s41467-023-40064-9 | |||
| 5385 | 8026 | 58 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL2 | 8026 | 58 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | 10.1038/s41467-023-40064-9 | |||
| 5282181 | 106733 | 43 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 400 | 6 | 2 | 2 | 6.6 | C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]23)C[C@@H](O)C[C@@H]1O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1601669 | 106733 | 43 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 400 | 6 | 2 | 2 | 6.6 | C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]23)C[C@@H](O)C[C@@H]1O | 10.1038/s41467-023-40064-9 | |||
| DB01436 | 106733 | 43 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 400 | 6 | 2 | 2 | 6.6 | C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@H]23)C[C@@H](O)C[C@@H]1O | 10.1038/s41467-023-40064-9 | |||
| CHEMBL5314356 | 387076 | 0 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | None | None | None | None | 10.1038/s41467-023-40064-9 | |||||
| 135564886 | 38403 | 5 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| 135673376 | 38403 | 5 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| 137157436 | 38403 | 5 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| 145948239 | 38403 | 5 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| 71587099 | 38403 | 5 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL1201304 | 38403 | 5 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| DB16024 | 38403 | 5 | None | None | None | Human | 5.1 | pAC50 | = | 5.1 | Binding | ChEMBL | 752 | 14 | 1 | 6 | 8.7 | CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21 | 10.1038/s41467-023-40064-9 | |||
| 1610 | 7967 | 67 | None | None | None | Human | 8.0 | pAC50 | = | 8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3941 | 7967 | 67 | None | None | None | Human | 8.0 | pAC50 | = | 8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 3961 | 7967 | 67 | None | None | None | Human | 8.0 | pAC50 | = | 8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Human | 8.0 | pAC50 | = | 8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1038/s41467-023-40064-9 | |||
| 2194 | 125802 | 64 | None | None | None | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 240 | 2 | 0 | 4 | 4.2 | COc1ccc(-c2cc(=S)ss2)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL178862 | 125802 | 64 | None | None | None | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 240 | 2 | 0 | 4 | 4.2 | COc1ccc(-c2cc(=S)ss2)cc1 | 10.1038/s41467-023-40064-9 | |||
| DB13853 | 125802 | 64 | None | None | None | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 240 | 2 | 0 | 4 | 4.2 | COc1ccc(-c2cc(=S)ss2)cc1 | 10.1038/s41467-023-40064-9 | |||
| 71329 | 353163 | 67 | None | None | None | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 441 | 11 | 2 | 6 | 2.0 | CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1 | 10.1038/s41467-023-40064-9 | |||
| CHEMBL473 | 353163 | 67 | None | None | None | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 441 | 11 | 2 | 6 | 2.0 | CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1 | 10.1038/s41467-023-40064-9 | |||
| DB00204 | 353163 | 67 | None | None | None | Human | 5.0 | pAC50 | = | 5.0 | Binding | ChEMBL | 441 | 11 | 2 | 6 | 2.0 | CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1 | 10.1038/s41467-023-40064-9 | |||
| 155540547 | 337039 | 0 | None | None | None | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 945 | 26 | 13 | 13 | -2.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4483576 | 337039 | 0 | None | None | None | Human | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 945 | 26 | 13 | 13 | -2.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155539027 | 346949 | 0 | None | None | None | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 944 | 26 | 13 | 12 | -1.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4514079 | 346949 | 0 | None | None | None | Rat | 8.0 | pEC50 | = | 8 | Binding | ChEMBL | 944 | 26 | 13 | 12 | -1.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155541295 | 347127 | 0 | None | None | None | Human | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 926 | 25 | 12 | 12 | -2.0 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4518318 | 347127 | 0 | None | None | None | Human | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 926 | 25 | 12 | 12 | -2.0 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155547844 | 347782 | 0 | None | None | None | Human | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 942 | 26 | 14 | 13 | -2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4535678 | 347782 | 0 | None | None | None | Human | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 942 | 26 | 14 | 13 | -2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155565112 | 349494 | 0 | None | None | None | Rat | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 1081 | 26 | 13 | 12 | -0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4577692 | 349494 | 0 | None | None | None | Rat | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 1081 | 26 | 13 | 12 | -0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155546362 | 347644 | 0 | None | None | None | Human | 6.0 | pEC50 | = | 6 | Binding | ChEMBL | 966 | 26 | 12 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4532075 | 347644 | 0 | None | None | None | Human | 6.0 | pEC50 | = | 6 | Binding | ChEMBL | 966 | 26 | 12 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155568289 | 350095 | 0 | None | None | None | Human | 6.0 | pEC50 | = | 6 | Binding | ChEMBL | 898 | 26 | 11 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4592000 | 350095 | 0 | None | None | None | Human | 6.0 | pEC50 | = | 6 | Binding | ChEMBL | 898 | 26 | 11 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155557139 | 348591 | 0 | None | None | None | Human | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 980 | 26 | 12 | 12 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4556070 | 348591 | 0 | None | None | None | Human | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 980 | 26 | 12 | 12 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155520024 | 347348 | 0 | None | None | None | Rat | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 959 | 27 | 13 | 12 | -1.6 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4524570 | 347348 | 0 | None | None | None | Rat | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 959 | 27 | 13 | 12 | -1.6 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155557139 | 348591 | 0 | None | None | None | Rat | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 980 | 26 | 12 | 12 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4556070 | 348591 | 0 | None | None | None | Rat | 5.0 | pEC50 | = | 5 | Binding | ChEMBL | 980 | 26 | 12 | 12 | -0.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 3542 | 484387 | 24 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | |||
| CHEMBL938 | 484387 | 24 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | |||
| 155544988 | 347539 | 0 | None | None | None | Rat | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 853 | 24 | 12 | 11 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O | nan | |||
| CHEMBL4529051 | 347539 | 0 | None | None | None | Rat | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 853 | 24 | 12 | 11 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O | nan | |||
| 155541440 | 347135 | 0 | None | None | None | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | |||
| CHEMBL4518530 | 347135 | 0 | None | None | None | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | |||
| 155540033 | 347010 | 0 | None | None | None | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | |||
| CHEMBL4515768 | 347010 | 0 | None | None | None | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | |||
| 155541125 | 347083 | 0 | None | None | None | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | nan | |||
| CHEMBL4517561 | 347083 | 0 | None | None | None | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | nan | |||
| 155540470 | 336995 | 0 | None | None | None | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.3 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4482867 | 336995 | 0 | None | None | None | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.3 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155559120 | 348823 | 0 | None | None | None | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -1.8 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4561769 | 348823 | 0 | None | None | None | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -1.8 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155564502 | 349273 | 0 | None | None | None | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 2296 | 33 | 30 | 27 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| CHEMBL4572408 | 349273 | 0 | None | None | None | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 2296 | 33 | 30 | 27 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| 54696627 | 198621 | 0 | None | None | None | Bovine | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 486 | 5 | 2 | 7 | 5.0 | Cc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL27511 | 198621 | 0 | None | None | None | Bovine | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 486 | 5 | 2 | 7 | 5.0 | Cc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1 | 10.1016/S0960-894X(01)81134-3 | |||
| 54726669 | 199484 | 0 | None | None | None | Bovine | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 461 | 5 | 2 | 6 | 4.6 | O=c1c(-c2ccccc2)c(O)c2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL281887 | 199484 | 0 | None | None | None | Bovine | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 461 | 5 | 2 | 6 | 4.6 | O=c1c(-c2ccccc2)c(O)c2c(n1Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)CCC2 | 10.1016/S0960-894X(01)81134-3 | |||
| 155539027 | 346949 | 0 | None | None | None | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 944 | 26 | 13 | 12 | -1.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4514079 | 346949 | 0 | None | None | None | Human | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 944 | 26 | 13 | 12 | -1.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(F)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155547428 | 347706 | 0 | None | None | None | Rat | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4533618 | 347706 | 0 | None | None | None | Rat | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155550799 | 348331 | 0 | None | None | None | Rat | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4549405 | 348331 | 0 | None | None | None | Rat | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155539838 | 347015 | 0 | None | None | None | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155543091 | 347015 | 0 | None | None | None | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155553311 | 347015 | 0 | None | None | None | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155568318 | 347015 | 0 | None | None | None | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4515848 | 347015 | 0 | None | None | None | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4522246 | 347015 | 0 | None | None | None | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4546162 | 347015 | 0 | None | None | None | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4591448 | 347015 | 0 | None | None | None | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155520014 | 347337 | 0 | None | None | None | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 975 | 27 | 14 | 13 | -1.9 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4524300 | 347337 | 0 | None | None | None | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 975 | 27 | 14 | 13 | -1.9 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL2028943 | 485018 | 0 | None | None | None | Rat | 7.9 | pEC50 | = | 7.9 | Binding | ChEMBL | 1018 | 28 | 13 | 13 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O | nan | |||
| CHEMBL2370909 | 485633 | 0 | None | None | None | Rat | 6.9 | pEC50 | = | 6.9 | Binding | ChEMBL | 984 | 29 | 13 | 13 | -2.3 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O | nan | |||
| 155542907 | 347287 | 0 | None | None | None | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 904 | 24 | 13 | 12 | -1.5 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C | nan | |||
| CHEMBL4522038 | 347287 | 0 | None | None | None | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 904 | 24 | 13 | 12 | -1.5 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C | nan | |||
| 155563676 | 349350 | 0 | None | None | None | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155565687 | 349350 | 0 | None | None | None | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4574199 | 349350 | 0 | None | None | None | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4579604 | 349350 | 0 | None | None | None | Human | 5.9 | pEC50 | = | 5.9 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL2392353 | 485980 | 4 | None | None | None | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 970 | 27 | 14 | 13 | -2.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| 3082475 | 8432 | 22 | None | None | None | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 926 | 26 | 12 | 12 | -2.1 | CNCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(=O)O)C)Cc1[nH]cnc1)[C@H](CC)C)Cc1ccc(cc1)O)C(C)C)CCCN=C(N)N | nan | |||
| 6902 | 8432 | 22 | None | None | None | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 926 | 26 | 12 | 12 | -2.1 | CNCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(=O)O)C)Cc1[nH]cnc1)[C@H](CC)C)Cc1ccc(cc1)O)C(C)C)CCCN=C(N)N | nan | |||
| CHEMBL4297447 | 8432 | 22 | None | None | None | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 926 | 26 | 12 | 12 | -2.1 | CNCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(=O)O)C)Cc1[nH]cnc1)[C@H](CC)C)Cc1ccc(cc1)O)C(C)C)CCCN=C(N)N | nan | |||
| DB12199 | 8432 | 22 | None | None | None | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 926 | 26 | 12 | 12 | -2.1 | CNCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(=O)O)C)Cc1[nH]cnc1)[C@H](CC)C)Cc1ccc(cc1)O)C(C)C)CCCN=C(N)N | nan | |||
| 155552429 | 348219 | 0 | None | None | None | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155568804 | 348219 | 0 | None | None | None | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4546799 | 348219 | 0 | None | None | None | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4591857 | 348219 | 0 | None | None | None | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155541240 | 347132 | 0 | None | None | None | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 928 | 26 | 12 | 11 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4518420 | 347132 | 0 | None | None | None | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 928 | 26 | 12 | 11 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155563538 | 349310 | 0 | None | None | None | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 925 | 26 | 13 | 12 | -2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O | nan | |||
| CHEMBL4573250 | 349310 | 0 | None | None | None | Human | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 925 | 26 | 13 | 12 | -2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O | nan | |||
| 155554529 | 348677 | 0 | None | None | None | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 961 | 26 | 13 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4557984 | 348677 | 0 | None | None | None | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 961 | 26 | 13 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 10533900 | 349944 | 16 | None | None | None | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | |||
| CHEMBL4588454 | 349944 | 16 | None | None | None | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | |||
| 155544246 | 347463 | 0 | None | None | None | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 887 | 24 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4527484 | 347463 | 0 | None | None | None | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 887 | 24 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155553003 | 348142 | 0 | None | None | None | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | |||
| CHEMBL4544308 | 348142 | 0 | None | None | None | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | |||
| 155561477 | 349208 | 0 | None | None | None | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 811 | 22 | 12 | 11 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4570840 | 349208 | 0 | None | None | None | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 811 | 22 | 12 | 11 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155562469 | 349236 | 0 | None | None | None | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 966 | 29 | 12 | 12 | -1.1 | C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 | nan | |||
| CHEMBL4571382 | 349236 | 0 | None | None | None | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 966 | 29 | 12 | 12 | -1.1 | C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 | nan | |||
| 155553930 | 349442 | 0 | None | None | None | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 1177 | 26 | 13 | 12 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4576650 | 349442 | 0 | None | None | None | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 1177 | 26 | 13 | 12 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155551279 | 348055 | 0 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 877 | 29 | 13 | 12 | -2.3 | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)CN[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | 10.1021/acs.jmedchem.8b00435 | |||
| CHEMBL4542269 | 348055 | 0 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 877 | 29 | 13 | 12 | -2.3 | CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)CN[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | 10.1021/acs.jmedchem.8b00435 | |||
| 3082475 | 8432 | 22 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 926 | 26 | 12 | 12 | -2.1 | CNCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(=O)O)C)Cc1[nH]cnc1)[C@H](CC)C)Cc1ccc(cc1)O)C(C)C)CCCN=C(N)N | nan | |||
| 6902 | 8432 | 22 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 926 | 26 | 12 | 12 | -2.1 | CNCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(=O)O)C)Cc1[nH]cnc1)[C@H](CC)C)Cc1ccc(cc1)O)C(C)C)CCCN=C(N)N | nan | |||
| CHEMBL4297447 | 8432 | 22 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 926 | 26 | 12 | 12 | -2.1 | CNCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(=O)O)C)Cc1[nH]cnc1)[C@H](CC)C)Cc1ccc(cc1)O)C(C)C)CCCN=C(N)N | nan | |||
| DB12199 | 8432 | 22 | None | None | None | Human | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 926 | 26 | 12 | 12 | -2.1 | CNCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(=O)O)C)Cc1[nH]cnc1)[C@H](CC)C)Cc1ccc(cc1)O)C(C)C)CCCN=C(N)N | nan | |||
| 70538373 | 349493 | 0 | None | None | None | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 840 | 23 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C | nan | |||
| CHEMBL4577691 | 349493 | 0 | None | None | None | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 840 | 23 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C | nan | |||
| 155554865 | 348406 | 0 | None | None | None | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 2269 | 27 | 21 | 24 | 3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| CHEMBL4551317 | 348406 | 0 | None | None | None | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 2269 | 27 | 21 | 24 | 3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| 54726671 | 195024 | 0 | None | None | None | Bovine | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 471 | 5 | 2 | 6 | 5.3 | O=c1c(-c2ccccc2)c(O)c2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL25226 | 195024 | 0 | None | None | None | Bovine | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 471 | 5 | 2 | 6 | 5.3 | O=c1c(-c2ccccc2)c(O)c2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81134-3 | |||
| 155560095 | 348952 | 0 | None | None | None | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 975 | 26 | 14 | 13 | -2.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4564950 | 348952 | 0 | None | None | None | Rat | 7.8 | pEC50 | = | 7.8 | Binding | ChEMBL | 975 | 26 | 14 | 13 | -2.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155563538 | 349310 | 0 | None | None | None | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 925 | 26 | 13 | 12 | -2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O | nan | |||
| CHEMBL4573250 | 349310 | 0 | None | None | None | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 925 | 26 | 13 | 12 | -2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O | nan | |||
| 155563676 | 349350 | 0 | None | None | None | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155565687 | 349350 | 0 | None | None | None | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4574199 | 349350 | 0 | None | None | None | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4579604 | 349350 | 0 | None | None | None | Rat | 6.8 | pEC50 | = | 6.8 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155556507 | 348534 | 0 | None | None | None | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 910 | 26 | 12 | 11 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4554466 | 348534 | 0 | None | None | None | Human | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 910 | 26 | 12 | 11 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 54726670 | 194379 | 0 | None | None | None | Bovine | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 491 | 7 | 2 | 5 | 6.2 | CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL24842 | 194379 | 0 | None | None | None | Bovine | 5.8 | pEC50 | = | 5.8 | Binding | ChEMBL | 491 | 7 | 2 | 5 | 6.2 | CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| 155560463 | 349067 | 0 | None | None | None | Rat | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1052 | 28 | 14 | 13 | -0.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | nan | |||
| CHEMBL4567667 | 349067 | 0 | None | None | None | Rat | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1052 | 28 | 14 | 13 | -0.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | nan | |||
| 155553003 | 348142 | 0 | None | None | None | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | |||
| CHEMBL4544308 | 348142 | 0 | None | None | None | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 791 | 23 | 12 | 11 | -4.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O)C(C)C)C(C)C | nan | |||
| 155554865 | 348406 | 0 | None | None | None | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 2269 | 27 | 21 | 24 | 3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| CHEMBL4551317 | 348406 | 0 | None | None | None | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 2269 | 27 | 21 | 24 | 3.8 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| 155564502 | 349273 | 0 | None | None | None | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 2296 | 33 | 30 | 27 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| CHEMBL4572408 | 349273 | 0 | None | None | None | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 2296 | 33 | 30 | 27 | -2.1 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| 155560463 | 349067 | 0 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1052 | 28 | 14 | 13 | -0.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | nan | |||
| CHEMBL4567667 | 349067 | 0 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 1052 | 28 | 14 | 13 | -0.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C | nan | |||
| 155551762 | 348078 | 0 | None | None | None | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 911 | 26 | 13 | 12 | -2.2 | CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4542709 | 348078 | 0 | None | None | None | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 911 | 26 | 13 | 12 | -2.2 | CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155552995 | 348175 | 0 | None | None | None | Rat | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 940 | 27 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL4545399 | 348175 | 0 | None | None | None | Rat | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 940 | 27 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| 155556530 | 348559 | 0 | None | None | None | Rat | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C | nan | |||
| CHEMBL4555119 | 348559 | 0 | None | None | None | Rat | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C | nan | |||
| 155568109 | 350012 | 0 | None | None | None | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -2.0 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4590381 | 350012 | 0 | None | None | None | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -2.0 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL2392353 | 485980 | 4 | None | None | None | Human | 7.7 | pEC50 | = | 7.7 | Binding | ChEMBL | 970 | 27 | 14 | 13 | -2.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| 155556530 | 348559 | 0 | None | None | None | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C | nan | |||
| CHEMBL4555119 | 348559 | 0 | None | None | None | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C)C(C)C | nan | |||
| 155552190 | 348136 | 0 | None | None | None | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 869 | 26 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4544228 | 348136 | 0 | None | None | None | Human | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 869 | 26 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155540470 | 336995 | 0 | None | None | None | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.3 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4482867 | 336995 | 0 | None | None | None | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.3 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155539838 | 347015 | 0 | None | None | None | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155543091 | 347015 | 0 | None | None | None | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155553311 | 347015 | 0 | None | None | None | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155568318 | 347015 | 0 | None | None | None | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4515848 | 347015 | 0 | None | None | None | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4522246 | 347015 | 0 | None | None | None | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4546162 | 347015 | 0 | None | None | None | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4591448 | 347015 | 0 | None | None | None | Rat | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 154573825 | 349963 | 16 | None | None | None | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | |||
| CHEMBL4588946 | 349963 | 16 | None | None | None | Human | 6.7 | pEC50 | = | 6.7 | Binding | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | |||
| 54726676 | 199445 | 0 | None | None | None | Bovine | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 501 | 6 | 2 | 7 | 5.3 | COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL28162 | 199445 | 0 | None | None | None | Bovine | 5.7 | pEC50 | = | 5.7 | Binding | ChEMBL | 501 | 6 | 2 | 7 | 5.3 | COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| 155540328 | 347021 | 0 | None | None | None | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | |||
| CHEMBL4516066 | 347021 | 0 | None | None | None | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | |||
| 155539838 | 347015 | 0 | None | None | None | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155543091 | 347015 | 0 | None | None | None | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155553311 | 347015 | 0 | None | None | None | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155568318 | 347015 | 0 | None | None | None | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4515848 | 347015 | 0 | None | None | None | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4522246 | 347015 | 0 | None | None | None | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4546162 | 347015 | 0 | None | None | None | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4591448 | 347015 | 0 | None | None | None | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155547428 | 347706 | 0 | None | None | None | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4533618 | 347706 | 0 | None | None | None | Human | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(Cl)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155559827 | 348945 | 0 | None | None | None | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 970 | 27 | 13 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4564617 | 348945 | 0 | None | None | None | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 970 | 27 | 13 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155565112 | 349494 | 0 | None | None | None | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 1081 | 26 | 13 | 12 | -0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4577692 | 349494 | 0 | None | None | None | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 1081 | 26 | 13 | 12 | -0.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155558784 | 348813 | 0 | None | None | None | Rat | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 756 | 9 | 7 | 8 | 1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| CHEMBL4561366 | 348813 | 0 | None | None | None | Rat | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 756 | 9 | 7 | 8 | 1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| 155540639 | 347052 | 0 | None | None | None | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155552475 | 347052 | 0 | None | None | None | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4516768 | 347052 | 0 | None | None | None | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4543860 | 347052 | 0 | None | None | None | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155553479 | 348239 | 0 | None | None | None | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 949 | 26 | 14 | 13 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4547423 | 348239 | 0 | None | None | None | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 949 | 26 | 14 | 13 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155558428 | 348767 | 0 | None | None | None | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 897 | 26 | 15 | 12 | -3.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4560224 | 348767 | 0 | None | None | None | Rat | 7.6 | pEC50 | = | 7.6 | Binding | ChEMBL | 897 | 26 | 15 | 12 | -3.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155553479 | 348239 | 0 | None | None | None | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 949 | 26 | 14 | 13 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4547423 | 348239 | 0 | None | None | None | Human | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 949 | 26 | 14 | 13 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155543972 | 349043 | 0 | None | None | None | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 917 | 28 | 13 | 12 | -1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4567103 | 349043 | 0 | None | None | None | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 917 | 28 | 13 | 12 | -1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155567790 | 350026 | 0 | None | None | None | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 877 | 24 | 13 | 12 | -3.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4590589 | 350026 | 0 | None | None | None | Rat | 6.6 | pEC50 | = | 6.6 | Binding | ChEMBL | 877 | 24 | 13 | 12 | -3.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155556507 | 348534 | 0 | None | None | None | Rat | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 910 | 26 | 12 | 11 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4554466 | 348534 | 0 | None | None | None | Rat | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 910 | 26 | 12 | 11 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 130762 | 198532 | 5 | None | None | None | Bovine | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL274447 | 198532 | 5 | None | None | None | Bovine | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81134-3 | |||
| 155568109 | 350012 | 0 | None | None | None | Rat | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -2.0 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4590381 | 350012 | 0 | None | None | None | Rat | 5.6 | pEC50 | = | 5.6 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -2.0 | CN[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL77838 | 489382 | 3 | None | None | None | Human | 8.5 | pEC50 | = | 8.5 | Binding | ChEMBL | 954 | 27 | 12 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O | nan | |||
| 155558428 | 348767 | 0 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 897 | 26 | 15 | 12 | -3.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4560224 | 348767 | 0 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 897 | 26 | 15 | 12 | -3.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155560095 | 348952 | 0 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 975 | 26 | 14 | 13 | -2.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4564950 | 348952 | 0 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 975 | 26 | 14 | 13 | -2.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155548506 | 347835 | 0 | None | None | None | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 926 | 25 | 13 | 12 | -1.9 | CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | |||
| CHEMBL4536886 | 347835 | 0 | None | None | None | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 926 | 25 | 13 | 12 | -1.9 | CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | |||
| 155569246 | 350148 | 0 | None | None | None | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 869 | 25 | 13 | 12 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4593310 | 350148 | 0 | None | None | None | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 869 | 25 | 13 | 12 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155552429 | 348219 | 0 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155568804 | 348219 | 0 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4546799 | 348219 | 0 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4591857 | 348219 | 0 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155539838 | 347015 | 0 | None | None | None | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155543091 | 347015 | 0 | None | None | None | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155553311 | 347015 | 0 | None | None | None | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155568318 | 347015 | 0 | None | None | None | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4515848 | 347015 | 0 | None | None | None | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4522246 | 347015 | 0 | None | None | None | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4546162 | 347015 | 0 | None | None | None | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4591448 | 347015 | 0 | None | None | None | Rat | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155539838 | 347015 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155543091 | 347015 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155553311 | 347015 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155568318 | 347015 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4515848 | 347015 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4522246 | 347015 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4546162 | 347015 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4591448 | 347015 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155550799 | 348331 | 0 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4549405 | 348331 | 0 | None | None | None | Human | 7.5 | pEC50 | = | 7.5 | Binding | ChEMBL | 959 | 26 | 13 | 12 | -1.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155540639 | 347052 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155552475 | 347052 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4516768 | 347052 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4543860 | 347052 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155544988 | 347539 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 853 | 24 | 12 | 11 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O | nan | |||
| CHEMBL4529051 | 347539 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 853 | 24 | 12 | 11 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(N)=O | nan | |||
| 155563676 | 349350 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155565687 | 349350 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4574199 | 349350 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4579604 | 349350 | 0 | None | None | None | Human | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 1610 | 7967 | 67 | None | None | None | Bovine | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81134-3 | |||
| 3941 | 7967 | 67 | None | None | None | Bovine | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81134-3 | |||
| 3961 | 7967 | 67 | None | None | None | Bovine | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Bovine | 6.5 | pEC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81134-3 | |||
| 155563973 | 349366 | 0 | None | None | None | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 941 | 27 | 14 | 13 | -3.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4574655 | 349366 | 0 | None | None | None | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 941 | 27 | 14 | 13 | -3.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155541295 | 347127 | 0 | None | None | None | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 926 | 25 | 12 | 12 | -2.0 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4518318 | 347127 | 0 | None | None | None | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 926 | 25 | 12 | 12 | -2.0 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 11944 | 8430 | 0 | None | None | None | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 903 | 24 | 12 | 12 | -2.3 | CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CC3=CN=CN3)C(=O)N4CCC[C@H]4C(=O)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC | nan | |||
| 145925550 | 8430 | 0 | None | None | None | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 903 | 24 | 12 | 12 | -2.3 | CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CC3=CN=CN3)C(=O)N4CCC[C@H]4C(=O)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC | nan | |||
| CHEMBL4577270 | 8430 | 0 | None | None | None | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 903 | 24 | 12 | 12 | -2.3 | CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CC3=CN=CN3)C(=O)N4CCC[C@H]4C(=O)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC | nan | |||
| 155539838 | 347015 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155543091 | 347015 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155553311 | 347015 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155568318 | 347015 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4515848 | 347015 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4522246 | 347015 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4546162 | 347015 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4591448 | 347015 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 11943 | 8428 | 0 | None | None | None | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | nan | |||
| 145925549 | 8428 | 0 | None | None | None | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | nan | |||
| 162679549 | 8428 | 0 | None | None | None | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | nan | |||
| CHEMBL4438122 | 8428 | 0 | None | None | None | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | nan | |||
| 155540033 | 347010 | 0 | None | None | None | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | |||
| CHEMBL4515768 | 347010 | 0 | None | None | None | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 953 | 27 | 13 | 12 | -1.9 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(C)C)C(N)=O | nan | |||
| 155520014 | 347337 | 0 | None | None | None | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 975 | 27 | 14 | 13 | -1.9 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4524300 | 347337 | 0 | None | None | None | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 975 | 27 | 14 | 13 | -1.9 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL312754 | 484256 | 17 | None | None | None | Rat | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 926 | 26 | 12 | 12 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| 155548506 | 347835 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 926 | 25 | 13 | 12 | -1.9 | CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | |||
| CHEMBL4536886 | 347835 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 926 | 25 | 13 | 12 | -1.9 | CN[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | |||
| 155548148 | 347798 | 0 | None | None | None | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 943 | 26 | 14 | 14 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4535997 | 347798 | 0 | None | None | None | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 943 | 26 | 14 | 14 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155554529 | 348677 | 0 | None | None | None | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 961 | 26 | 13 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4557984 | 348677 | 0 | None | None | None | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 961 | 26 | 13 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(F)cc(O)cc1F)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155566196 | 349730 | 0 | None | None | None | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 954 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4583284 | 349730 | 0 | None | None | None | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 954 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155558003 | 348733 | 0 | None | None | None | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 1015 | 28 | 13 | 16 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4559421 | 348733 | 0 | None | None | None | Rat | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 1015 | 28 | 13 | 16 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 70538373 | 349493 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 840 | 23 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C | nan | |||
| CHEMBL4577691 | 349493 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 840 | 23 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C | nan | |||
| 154573825 | 349963 | 16 | None | None | None | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | |||
| CHEMBL4588946 | 349963 | 16 | None | None | None | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 742 | 22 | 12 | 10 | -2.4 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O)C(C)C)C(C)C | nan | |||
| 155561477 | 349208 | 0 | None | None | None | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 811 | 22 | 12 | 11 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4570840 | 349208 | 0 | None | None | None | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 811 | 22 | 12 | 11 | -3.0 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155559104 | 348841 | 0 | None | None | None | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 940 | 26 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL4562270 | 348841 | 0 | None | None | None | Rat | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 940 | 26 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| 155540639 | 347052 | 0 | None | None | None | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155552475 | 347052 | 0 | None | None | None | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4516768 | 347052 | 0 | None | None | None | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4543860 | 347052 | 0 | None | None | None | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155560024 | 348921 | 0 | None | None | None | Rat | 4.4 | pEC50 | = | 4.4 | Binding | ChEMBL | 782 | 21 | 11 | 10 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4564094 | 348921 | 0 | None | None | None | Rat | 4.4 | pEC50 | = | 4.4 | Binding | ChEMBL | 782 | 21 | 11 | 10 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 11943 | 8428 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | 10.1021/acs.jmedchem.8b00435 | |||
| 145925549 | 8428 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | 10.1021/acs.jmedchem.8b00435 | |||
| 162679549 | 8428 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | 10.1021/acs.jmedchem.8b00435 | |||
| CHEMBL4438122 | 8428 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | 10.1021/acs.jmedchem.8b00435 | |||
| 11943 | 8428 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | nan | |||
| 145925549 | 8428 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | nan | |||
| 162679549 | 8428 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | nan | |||
| CHEMBL4438122 | 8428 | 0 | None | None | None | Human | 7.4 | pEC50 | = | 7.4 | Binding | ChEMBL | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | nan | |||
| 155542907 | 347287 | 0 | None | None | None | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 904 | 24 | 13 | 12 | -1.5 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C | nan | |||
| CHEMBL4522038 | 347287 | 0 | None | None | None | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 904 | 24 | 13 | 12 | -1.5 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C | nan | |||
| 155541125 | 347083 | 0 | None | None | None | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | nan | |||
| CHEMBL4517561 | 347083 | 0 | None | None | None | Human | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | nan | |||
| 155540639 | 347052 | 0 | None | None | None | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155552475 | 347052 | 0 | None | None | None | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4516768 | 347052 | 0 | None | None | None | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4543860 | 347052 | 0 | None | None | None | Rat | 6.4 | pEC50 | = | 6.4 | Binding | ChEMBL | 947 | 25 | 14 | 13 | -2.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155561376 | 349666 | 0 | None | None | None | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 917 | 28 | 12 | 11 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O | nan | |||
| CHEMBL4581718 | 349666 | 0 | None | None | None | Human | 5.4 | pEC50 | = | 5.4 | Binding | ChEMBL | 917 | 28 | 12 | 11 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(N)=O | nan | |||
| 155560024 | 348921 | 0 | None | None | None | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 782 | 21 | 11 | 10 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4564094 | 348921 | 0 | None | None | None | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 782 | 21 | 11 | 10 | -1.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155553098 | 348173 | 0 | None | None | None | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 969 | 28 | 16 | 13 | -3.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4545153 | 348173 | 0 | None | None | None | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 969 | 28 | 16 | 13 | -3.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155539838 | 347015 | 0 | None | None | None | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155543091 | 347015 | 0 | None | None | None | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155553311 | 347015 | 0 | None | None | None | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155568318 | 347015 | 0 | None | None | None | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4515848 | 347015 | 0 | None | None | None | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4522246 | 347015 | 0 | None | None | None | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4546162 | 347015 | 0 | None | None | None | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4591448 | 347015 | 0 | None | None | None | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155540547 | 337039 | 0 | None | None | None | Rat | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 945 | 26 | 13 | 13 | -2.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4483576 | 337039 | 0 | None | None | None | Rat | 8.3 | pEC50 | = | 8.3 | Binding | ChEMBL | 945 | 26 | 13 | 13 | -2.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(F)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155548148 | 347798 | 0 | None | None | None | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 943 | 26 | 14 | 14 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4535997 | 347798 | 0 | None | None | None | Human | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 943 | 26 | 14 | 14 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(O)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155551762 | 348078 | 0 | None | None | None | Rat | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 911 | 26 | 13 | 12 | -2.2 | CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4542709 | 348078 | 0 | None | None | None | Rat | 7.3 | pEC50 | = | 7.3 | Binding | ChEMBL | 911 | 26 | 13 | 12 | -2.2 | CCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155546362 | 347644 | 0 | None | None | None | Rat | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 966 | 26 | 12 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4532075 | 347644 | 0 | None | None | None | Rat | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 966 | 26 | 12 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN1CCCC1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155553930 | 349442 | 0 | None | None | None | Rat | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 1177 | 26 | 13 | 12 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4576650 | 349442 | 0 | None | None | None | Rat | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 1177 | 26 | 13 | 12 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 54726675 | 199581 | 0 | None | None | None | Bovine | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 515 | 7 | 2 | 7 | 5.7 | CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL282566 | 199581 | 0 | None | None | None | Bovine | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 515 | 7 | 2 | 7 | 5.7 | CCOc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| 155558003 | 348733 | 0 | None | None | None | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 1015 | 28 | 13 | 16 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4559421 | 348733 | 0 | None | None | None | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 1015 | 28 | 13 | 16 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 86727577 | 234911 | 0 | None | None | None | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 422 | 2 | 1 | 5 | 3.6 | C[C@H]1CN(C)CC[C@H]1c1cc2c(cc1-c1ccccc1F)OCC1=NNC(=O)[C@@H](C)N12 | 10.1021/jm5013006 | |||
| CHEMBL3355127 | 234911 | 0 | None | None | None | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 422 | 2 | 1 | 5 | 3.6 | C[C@H]1CN(C)CC[C@H]1c1cc2c(cc1-c1ccccc1F)OCC1=NNC(=O)[C@@H](C)N12 | 10.1021/jm5013006 | |||
| 155555310 | 348411 | 0 | None | None | None | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 931 | 25 | 13 | 12 | -2.2 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4551431 | 348411 | 0 | None | None | None | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 931 | 25 | 13 | 12 | -2.2 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155555310 | 348411 | 0 | None | None | None | Rat | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 931 | 25 | 13 | 12 | -2.2 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4551431 | 348411 | 0 | None | None | None | Rat | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 931 | 25 | 13 | 12 | -2.2 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 10533900 | 349944 | 16 | None | None | None | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | |||
| CHEMBL4588454 | 349944 | 16 | None | None | None | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 955 | 27 | 14 | 13 | -2.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O | nan | |||
| 90219582 | 234912 | 0 | None | None | None | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 436 | 2 | 1 | 5 | 3.9 | Cc1ccc(-c2cc3c(cc2[C@@H]2CCN(C)C[C@@H]2C)N2C(=NNC(=O)[C@H]2C)CO3)c(F)c1 | 10.1021/jm5013006 | |||
| CHEMBL3355137 | 234912 | 0 | None | None | None | Human | 5.3 | pEC50 | = | 5.3 | Binding | ChEMBL | 436 | 2 | 1 | 5 | 3.9 | Cc1ccc(-c2cc3c(cc2[C@@H]2CCN(C)C[C@@H]2C)N2C(=NNC(=O)[C@H]2C)CO3)c(F)c1 | 10.1021/jm5013006 | |||
| 155552995 | 348175 | 0 | None | None | None | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 940 | 27 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL4545399 | 348175 | 0 | None | None | None | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 940 | 27 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OC)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL77838 | 489382 | 3 | None | None | None | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 954 | 27 | 12 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(C)C)C(=O)O | nan | |||
| 172198 | 866 | 40 | None | None | None | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | |||
| 2504 | 866 | 40 | None | None | None | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | |||
| 5272 | 866 | 40 | None | None | None | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | |||
| CHEMBL408403 | 866 | 40 | None | None | None | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | |||
| DB11842 | 866 | 40 | None | None | None | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | |||
| P01015 | 866 | 40 | None | None | None | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | |||
| P01019 | 866 | 40 | None | None | None | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | |||
| P11859 | 866 | 40 | None | None | None | Rat | 8.2 | pEC50 | = | 8.2 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | |||
| 54726672 | 199519 | 0 | None | None | None | Bovine | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 517 | 6 | 2 | 7 | 6.0 | CSc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL282082 | 199519 | 0 | None | None | None | Bovine | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 517 | 6 | 2 | 7 | 6.0 | CSc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| 54726668 | 197558 | 0 | None | None | None | Bovine | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 477 | 5 | 2 | 7 | 5.3 | O=c1c(-c2ccccc2)c(O)c2sccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL26875 | 197558 | 0 | None | None | None | Bovine | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 477 | 5 | 2 | 7 | 5.3 | O=c1c(-c2ccccc2)c(O)c2sccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81134-3 | |||
| 155559827 | 348945 | 0 | None | None | None | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 970 | 27 | 13 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4564617 | 348945 | 0 | None | None | None | Human | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 970 | 27 | 13 | 14 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c([N+](=O)[O-])c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155539838 | 347015 | 0 | None | None | None | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155543091 | 347015 | 0 | None | None | None | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155553311 | 347015 | 0 | None | None | None | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155568318 | 347015 | 0 | None | None | None | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4515848 | 347015 | 0 | None | None | None | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4522246 | 347015 | 0 | None | None | None | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4546162 | 347015 | 0 | None | None | None | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4591448 | 347015 | 0 | None | None | None | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 940 | 26 | 13 | 12 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155547844 | 347782 | 0 | None | None | None | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 942 | 26 | 14 | 13 | -2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4535678 | 347782 | 0 | None | None | None | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 942 | 26 | 14 | 13 | -2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)c(O)c1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155553098 | 348173 | 0 | None | None | None | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 969 | 28 | 16 | 13 | -3.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| CHEMBL4545153 | 348173 | 0 | None | None | None | Rat | 7.2 | pEC50 | = | 7.2 | Binding | ChEMBL | 969 | 28 | 16 | 13 | -3.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C | nan | |||
| 155566196 | 349730 | 0 | None | None | None | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 954 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4583284 | 349730 | 0 | None | None | None | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 954 | 26 | 13 | 12 | -1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c(C)cc(O)cc1C)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155567790 | 350026 | 0 | None | None | None | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 877 | 24 | 13 | 12 | -3.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4590589 | 350026 | 0 | None | None | None | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 877 | 24 | 13 | 12 | -3.1 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155562469 | 349236 | 0 | None | None | None | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 966 | 29 | 12 | 12 | -1.1 | C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 | nan | |||
| CHEMBL4571382 | 349236 | 0 | None | None | None | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 966 | 29 | 12 | 12 | -1.1 | C=CCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N2CCC[C@H]2C(=O)N[C@H](C)C(=O)O)[C@@H](C)CC)cc1 | nan | |||
| 155568289 | 350095 | 0 | None | None | None | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 898 | 26 | 11 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4592000 | 350095 | 0 | None | None | None | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 898 | 26 | 11 | 12 | -1.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 155544246 | 347463 | 0 | None | None | None | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 887 | 24 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4527484 | 347463 | 0 | None | None | None | Rat | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 887 | 24 | 12 | 11 | -1.8 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155520024 | 347348 | 0 | None | None | None | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 959 | 27 | 13 | 12 | -1.6 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4524570 | 347348 | 0 | None | None | None | Human | 5.2 | pEC50 | = | 5.2 | Binding | ChEMBL | 959 | 27 | 13 | 12 | -1.6 | CN[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155558784 | 348813 | 0 | None | None | None | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 756 | 9 | 7 | 8 | 1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| CHEMBL4561366 | 348813 | 0 | None | None | None | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 756 | 9 | 7 | 8 | 1.3 | CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2cnc[nH]2)NC1=O | nan | |||
| 155543972 | 349043 | 0 | None | None | None | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 917 | 28 | 13 | 12 | -1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4567103 | 349043 | 0 | None | None | None | Human | 6.2 | pEC50 | = | 6.2 | Binding | ChEMBL | 917 | 28 | 13 | 12 | -1.7 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| 3542 | 484387 | 24 | None | None | None | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | |||
| CHEMBL938 | 484387 | 24 | None | None | None | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | nan | |||
| 155552886 | 348161 | 0 | None | None | None | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 961 | 26 | 13 | 13 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4544902 | 348161 | 0 | None | None | None | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 961 | 26 | 13 | 13 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155552886 | 348161 | 0 | None | None | None | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 961 | 26 | 13 | 13 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4544902 | 348161 | 0 | None | None | None | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 961 | 26 | 13 | 13 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)c(Cl)c1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 11944 | 8430 | 0 | None | None | None | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 903 | 24 | 12 | 12 | -2.3 | CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CC3=CN=CN3)C(=O)N4CCC[C@H]4C(=O)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC | nan | |||
| 145925550 | 8430 | 0 | None | None | None | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 903 | 24 | 12 | 12 | -2.3 | CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CC3=CN=CN3)C(=O)N4CCC[C@H]4C(=O)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC | nan | |||
| CHEMBL4577270 | 8430 | 0 | None | None | None | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 903 | 24 | 12 | 12 | -2.3 | CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CC3=CN=CN3)C(=O)N4CCC[C@H]4C(=O)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC | nan | |||
| 155559104 | 348841 | 0 | None | None | None | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 940 | 26 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| CHEMBL4562270 | 348841 | 0 | None | None | None | Human | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 940 | 26 | 12 | 12 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| 155541240 | 347132 | 0 | None | None | None | Rat | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 928 | 26 | 12 | 11 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL4518420 | 347132 | 0 | None | None | None | Rat | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 928 | 26 | 12 | 11 | -1.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(=O)O | nan | |||
| CHEMBL2028943 | 485018 | 0 | None | None | None | Human | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 1018 | 28 | 13 | 13 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O | nan | |||
| 155552429 | 348219 | 0 | None | None | None | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155568804 | 348219 | 0 | None | None | None | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4546799 | 348219 | 0 | None | None | None | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4591857 | 348219 | 0 | None | None | None | Rat | 8.1 | pEC50 | = | 8.1 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155540328 | 347021 | 0 | None | None | None | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | |||
| CHEMBL4516066 | 347021 | 0 | None | None | None | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 1017 | 28 | 14 | 13 | -1.6 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(N)=O | nan | |||
| 155563676 | 349350 | 0 | None | None | None | Rat | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155565687 | 349350 | 0 | None | None | None | Rat | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4574199 | 349350 | 0 | None | None | None | Rat | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4579604 | 349350 | 0 | None | None | None | Rat | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 961 | 26 | 14 | 13 | -2.1 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| 155559120 | 348823 | 0 | None | None | None | Rat | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -1.8 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL4561769 | 348823 | 0 | None | None | None | Rat | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 945 | 26 | 13 | 12 | -1.8 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O | nan | |||
| CHEMBL2370909 | 485633 | 0 | None | None | None | Human | 6.1 | pEC50 | = | 6.1 | Binding | ChEMBL | 984 | 29 | 13 | 13 | -2.3 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)O | nan | |||
| 155552429 | 348219 | 0 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| 155568804 | 348219 | 0 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4546799 | 348219 | 0 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL4591857 | 348219 | 0 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 927 | 26 | 13 | 13 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)[C@@H](C)OC)C(C)C | nan | |||
| CHEMBL312754 | 484256 | 17 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 926 | 26 | 12 | 12 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | nan | |||
| 155541440 | 347135 | 0 | None | None | None | Rat | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | |||
| CHEMBL4518530 | 347135 | 0 | None | None | None | Rat | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 954 | 28 | 13 | 12 | -1.1 | CCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | nan | |||
| 172198 | 866 | 40 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | |||
| 2504 | 866 | 40 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | |||
| 5272 | 866 | 40 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | |||
| CHEMBL408403 | 866 | 40 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | |||
| DB11842 | 866 | 40 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | |||
| P01015 | 866 | 40 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | |||
| P01019 | 866 | 40 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | |||
| P11859 | 866 | 40 | None | None | None | Human | 8.0 | pEC50 | = | 8.0 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | nan | |||
| 54726674 | 199919 | 0 | None | None | None | Bovine | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 505 | 6 | 2 | 7 | 5.9 | CCc1cc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2s1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL284877 | 199919 | 0 | None | None | None | Bovine | 7.1 | pEC50 | = | 7.1 | Binding | ChEMBL | 505 | 6 | 2 | 7 | 5.9 | CCc1cc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2s1 | 10.1016/S0960-894X(01)81134-3 | |||
| 155552190 | 348136 | 0 | None | None | None | Rat | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 869 | 26 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4544228 | 348136 | 0 | None | None | None | Rat | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 869 | 26 | 13 | 12 | -2.9 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 155558059 | 348723 | 0 | None | None | None | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 790 | 23 | 12 | 11 | -4.6 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C | nan | |||
| CHEMBL4559239 | 348723 | 0 | None | None | None | Human | 6.0 | pEC50 | = | 6.0 | Binding | ChEMBL | 790 | 23 | 12 | 11 | -4.6 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O)C(C)C)C(C)C | nan | |||
| 155569246 | 350148 | 0 | None | None | None | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 869 | 25 | 13 | 12 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| CHEMBL4593310 | 350148 | 0 | None | None | None | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 869 | 25 | 13 | 12 | -3.2 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C | nan | |||
| 54726673 | 199442 | 0 | None | None | None | Bovine | 5.0 | pEC50 | = | 5.0 | Binding | ChEMBL | 477 | 6 | 2 | 5 | 5.8 | COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| CHEMBL28160 | 199442 | 0 | None | None | None | Bovine | 5.0 | pEC50 | = | 5.0 | Binding | ChEMBL | 477 | 6 | 2 | 5 | 5.8 | COc1ccc2c(O)c(-c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/S0960-894X(01)81134-3 | |||
| 10032858 | 63414 | 0 | None | None | None | Rabbit | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 729 | 12 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL138690 | 63414 | 0 | None | None | None | Rabbit | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 729 | 12 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10032858 | 63414 | 0 | None | None | None | Rabbit | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 729 | 12 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL138690 | 63414 | 0 | None | None | None | Rabbit | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | 729 | 12 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00052a006 | |||
| 9895212 | 238372 | 0 | None | None | None | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 614 | 9 | 1 | 6 | 7.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL346728 | 238372 | 0 | None | None | None | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 614 | 9 | 1 | 6 | 7.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| 10417251 | 197229 | 0 | None | None | None | Rabbit | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL265797 | 197229 | 0 | None | None | None | Rabbit | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10417251 | 197229 | 0 | None | None | None | Rabbit | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL265797 | 197229 | 0 | None | None | None | Rabbit | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 10417251 | 197229 | 0 | None | None | None | Rabbit | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL265797 | 197229 | 0 | None | None | None | Rabbit | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 691 | 11 | 2 | 8 | 6.5 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10349732 | 237549 | 0 | None | None | None | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 695 | 13 | 2 | 9 | 7.1 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL341828 | 237549 | 0 | None | None | None | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 695 | 13 | 2 | 9 | 7.1 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| 10032820 | 236152 | 0 | None | None | None | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339672 | 236152 | 0 | None | None | None | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| 10032820 | 236152 | 0 | None | None | None | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339672 | 236152 | 0 | None | None | None | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 10349732 | 237549 | 0 | None | None | None | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 695 | 13 | 2 | 9 | 7.1 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| CHEMBL341828 | 237549 | 0 | None | None | None | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 695 | 13 | 2 | 9 | 7.1 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| 10032820 | 236152 | 0 | None | None | None | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339672 | 236152 | 0 | None | None | None | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| 10439848 | 237984 | 0 | None | None | None | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL343309 | 237984 | 0 | None | None | None | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10439848 | 237984 | 0 | None | None | None | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL343309 | 237984 | 0 | None | None | None | Rabbit | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)C3CC3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10010071 | 236196 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339722 | 236196 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 9829012 | 183364 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL24322 | 183364 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 44311455 | 202804 | 0 | None | None | None | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 782 | 17 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL305017 | 202804 | 0 | None | None | None | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 782 | 17 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311580 | 202836 | 0 | None | None | None | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 706 | 16 | 2 | 9 | 6.9 | CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL305238 | 202836 | 0 | None | None | None | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 706 | 16 | 2 | 9 | 6.9 | CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311676 | 203110 | 0 | None | None | None | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 706 | 17 | 2 | 9 | 7.0 | CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL307318 | 203110 | 0 | None | None | None | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 706 | 17 | 2 | 9 | 7.0 | CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311435 | 468977 | 0 | None | None | None | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 693 | 17 | 1 | 9 | 7.3 | CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL69721 | 468977 | 0 | None | None | None | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 693 | 17 | 1 | 9 | 7.3 | CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311415 | 469031 | 0 | None | None | None | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 705 | 17 | 1 | 9 | 7.5 | CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70161 | 469031 | 0 | None | None | None | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 705 | 17 | 1 | 9 | 7.5 | CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311434 | 469065 | 0 | None | None | None | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 7.5 | CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70370 | 469065 | 0 | None | None | None | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 7.5 | CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311072 | 469115 | 0 | None | None | None | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 679 | 15 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70789 | 469115 | 0 | None | None | None | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 679 | 15 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311073 | 469127 | 0 | None | None | None | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 746 | 16 | 1 | 10 | 6.6 | CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70843 | 469127 | 0 | None | None | None | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 746 | 16 | 1 | 10 | 6.6 | CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311414 | 469148 | 0 | None | None | None | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 677 | 15 | 1 | 9 | 6.8 | CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70935 | 469148 | 0 | None | None | None | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 677 | 15 | 1 | 9 | 6.8 | CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 9829012 | 183364 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL24322 | 183364 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 73347893 | 183435 | 0 | None | None | None | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435828 | 183435 | 0 | None | None | None | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(NC(=O)CCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 9829012 | 183364 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24322 | 183364 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 19754061 | 202794 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 657 | 15 | 2 | 7 | 7.7 | CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL304947 | 202794 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 657 | 15 | 2 | 7 | 7.7 | CCCCC(=O)Nc1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)CCC4CCCC4)cc3)c2nc1C | 10.1016/S0960-894X(01)81115-X | |||
| 44309719 | 468833 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 544 | 9 | 1 | 6 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL68638 | 468833 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 544 | 9 | 1 | 6 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 10010071 | 236196 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339722 | 236196 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 9829012 | 183364 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL24322 | 183364 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| 9829012 | 183364 | 0 | None | None | None | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm058225d | |||
| CHEMBL24322 | 183364 | 0 | None | None | None | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 550 | 9 | 2 | 7 | 5.5 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm058225d | |||
| 9809961 | 216803 | 2 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL316300 | 216803 | 2 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10439862 | 237564 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 719 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL341934 | 237564 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 719 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10010195 | 237958 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 733 | 13 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL343142 | 237958 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 733 | 13 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 9809961 | 216803 | 2 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL316300 | 216803 | 2 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 9917295 | 203008 | 19 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 633 | 15 | 2 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL306407 | 203008 | 19 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 633 | 15 | 2 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)c(C)nc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 9809961 | 216803 | 2 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316300 | 216803 | 2 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| 9809961 | 216803 | 2 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL316300 | 216803 | 2 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10439862 | 237564 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 719 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL341934 | 237564 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 719 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NC(=O)CCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10010195 | 237958 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 733 | 13 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL343142 | 237958 | 0 | None | None | None | Rabbit | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 733 | 13 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)CC(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10395394 | 65507 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 767 | 13 | 2 | 8 | 7.7 | CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL140708 | 65507 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 767 | 13 | 2 | 8 | 7.7 | CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10032851 | 40718 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL124771 | 40718 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 9809637 | 468831 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 643 | 15 | 2 | 7 | 7.4 | CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL68618 | 468831 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 643 | 15 | 2 | 7 | 7.4 | CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 10032851 | 40718 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL124771 | 40718 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10395394 | 65507 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 767 | 13 | 2 | 8 | 7.7 | CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL140708 | 65507 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 767 | 13 | 2 | 8 | 7.7 | CCCCc1nn(-c2cc(NC(=O)Cc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44210588 | 239007 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 633 | 12 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL353037 | 239007 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 633 | 12 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10032851 | 40718 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL124771 | 40718 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10327309 | 232919 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL332576 | 232919 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1007/s00044-011-9815-x | |||
| 10395335 | 235940 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339256 | 235940 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| 10372451 | 236142 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339605 | 236142 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10327309 | 232919 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL332576 | 232919 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 691 | 12 | 2 | 9 | 6.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1021/jm00019a004 | |||
| 10395335 | 235940 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339256 | 235940 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 10372451 | 236142 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339605 | 236142 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10372093 | 222237 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 652 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330533 | 222237 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 652 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1 | 10.1021/jm00043a020 | |||
| 44314822 | 202999 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL306362 | 202999 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10259411 | 64304 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 734 | 13 | 3 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL139452 | 64304 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 734 | 13 | 3 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10485116 | 235736 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL338101 | 235736 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| 10462598 | 233158 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL332909 | 233158 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1007/s00044-011-9815-x | |||
| 10485116 | 235736 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338101 | 235736 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10395076 | 333246 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL435811 | 333246 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10462598 | 233158 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL332909 | 233158 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | |||
| 10485116 | 235736 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338101 | 235736 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10395076 | 333246 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL435811 | 333246 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10395076 | 333246 | 0 | None | None | None | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL435811 | 333246 | 0 | None | None | None | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10259411 | 64304 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 734 | 13 | 3 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL139452 | 64304 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 734 | 13 | 3 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10485116 | 235736 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| CHEMBL338101 | 235736 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| 10462598 | 233158 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL332909 | 233158 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1007/s00044-011-9815-x | |||
| 10485116 | 235736 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338101 | 235736 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.0 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10395076 | 333246 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL435811 | 333246 | 0 | None | None | None | Rabbit | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 19939453 | 221876 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 686 | 10 | 1 | 7 | 7.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL329679 | 221876 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 686 | 10 | 1 | 7 | 7.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10326797 | 474459 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 640 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94905 | 474459 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 640 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCC2)cc1 | 10.1021/jm00043a020 | |||
| 44381724 | 238976 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 651 | 11 | 3 | 7 | 6.1 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352771 | 238976 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 651 | 11 | 3 | 7 | 6.1 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44381671 | 239078 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 647 | 13 | 3 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL353800 | 239078 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 647 | 13 | 3 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10259395 | 60663 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 11 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL136465 | 60663 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 11 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10078663 | 474658 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL96075 | 474658 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| 9853391 | 235722 | 1 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338027 | 235722 | 1 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10101608 | 235894 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL339004 | 235894 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10078663 | 474658 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL96075 | 474658 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1016/S0960-894X(01)80595-3 | |||
| 9853391 | 235722 | 1 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338027 | 235722 | 1 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10101608 | 235894 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL339004 | 235894 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10009273 | 216863 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 636 | 11 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316706 | 216863 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 636 | 11 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)C(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10259395 | 60663 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 11 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL136465 | 60663 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 11 | 2 | 8 | 7.5 | CCCCc1nn(-c2cc(NC(=O)C(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10078663 | 474658 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| CHEMBL96075 | 474658 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 733 | 14 | 2 | 8 | 7.6 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| 9853391 | 235722 | 1 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338027 | 235722 | 1 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10101608 | 235894 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL339004 | 235894 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10101284 | 474296 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL93907 | 474296 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10372659 | 236917 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL340632 | 236917 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10101284 | 474296 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL93907 | 474296 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-011-9815-x | |||
| 54693559 | 469440 | 6 | None | None | None | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 425 | 4 | 2 | 8 | 3.0 | Cc1nc(C)c2c(O)cc(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1 | 10.1021/jm0204237 | |||
| CHEMBL72838 | 469440 | 6 | None | None | None | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 425 | 4 | 2 | 8 | 3.0 | Cc1nc(C)c2c(O)cc(=O)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2n1 | 10.1021/jm0204237 | |||
| 10101284 | 474296 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL93907 | 474296 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 10372659 | 236917 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL340632 | 236917 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10101284 | 474296 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL93907 | 474296 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00019a004 | |||
| 10417351 | 474816 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 706 | 10 | 1 | 8 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97075 | 474816 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 706 | 10 | 1 | 8 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| 44327912 | 474981 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 748 | 12 | 1 | 9 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3o2)cc1.CCOCC | 10.1021/jm00043a020 | |||
| CHEMBL98068 | 474981 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 748 | 12 | 1 | 9 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3o2)cc1.CCOCC | 10.1021/jm00043a020 | |||
| 10101284 | 474296 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL93907 | 474296 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44381413 | 239357 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 661 | 14 | 3 | 8 | 6.6 | CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL354779 | 239357 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 661 | 14 | 3 | 8 | 6.6 | CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10101284 | 474296 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL93907 | 474296 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 705 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-011-9815-x | |||
| 10372659 | 236917 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL340632 | 236917 | 0 | None | None | None | Rabbit | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10327537 | 235576 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 719 | 12 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL337118 | 235576 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 719 | 12 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10327537 | 235576 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 719 | 12 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL337118 | 235576 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 719 | 12 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(=O)C(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44210586 | 121796 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 619 | 12 | 3 | 8 | 5.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169221 | 121796 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 619 | 12 | 3 | 8 | 5.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44381527 | 121857 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 633 | 13 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169568 | 121857 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 633 | 13 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NCCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10462933 | 40764 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL125008 | 40764 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 76333473 | 175859 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 771 | 13 | 2 | 8 | 8.0 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL2236976 | 175859 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 771 | 13 | 2 | 8 | 8.0 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10462933 | 40764 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL125008 | 40764 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44348523 | 222635 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL331450 | 222635 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10078397 | 26380 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 692 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1184032 | 26380 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 692 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occ(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | |||
| 44315351 | 214587 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311160 | 214587 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 44314823 | 317396 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL415073 | 317396 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 44381427 | 238942 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 632 | 14 | 2 | 8 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352503 | 238942 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 632 | 14 | 2 | 8 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)CCCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10462933 | 40764 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL125008 | 40764 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 76333473 | 175859 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 771 | 13 | 2 | 8 | 8.0 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL2236976 | 175859 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 771 | 13 | 2 | 8 | 8.0 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10439837 | 40242 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL122917 | 40242 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10462683 | 232332 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL331507 | 232332 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 44311289 | 202314 | 0 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 7.7 | CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL302964 | 202314 | 0 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 7.7 | CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311456 | 202384 | 0 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 792 | 19 | 1 | 10 | 8.6 | CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL303427 | 202384 | 0 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 792 | 19 | 1 | 10 | 8.6 | CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311715 | 203244 | 0 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 17 | 1 | 10 | 6.7 | CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL308323 | 203244 | 0 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 17 | 1 | 10 | 6.7 | CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311074 | 214601 | 0 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 732 | 15 | 1 | 10 | 6.2 | CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL311253 | 214601 | 0 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 732 | 15 | 1 | 10 | 6.2 | CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311412 | 215024 | 0 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 725 | 17 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)OCCC[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL311625 | 215024 | 0 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 725 | 17 | 1 | 9 | 7.1 | CCCc1nc(CC)c(C(=O)OCCC[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311581 | 332594 | 0 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 720 | 17 | 2 | 9 | 7.3 | CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL430792 | 332594 | 0 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 720 | 17 | 2 | 9 | 7.3 | CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311582 | 469135 | 0 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 790 | 21 | 1 | 9 | 8.5 | CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70868 | 469135 | 0 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 790 | 21 | 1 | 9 | 8.5 | CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 9918412 | 469186 | 0 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 739 | 16 | 1 | 9 | 8.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL71172 | 469186 | 0 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 739 | 16 | 1 | 9 | 8.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311413 | 469267 | 0 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 709 | 17 | 1 | 9 | 8.1 | CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL71639 | 469267 | 0 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 709 | 17 | 1 | 9 | 8.1 | CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311753 | 469508 | 0 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 773 | 16 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL73283 | 469508 | 0 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 773 | 16 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 133031 | 201002 | 20 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL293511 | 201002 | 20 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 19939756 | 19377 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 534 | 9 | 1 | 7 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| CHEMBL105199 | 19377 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 534 | 9 | 1 | 7 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| 133031 | 201002 | 20 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| CHEMBL293511 | 201002 | 20 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| 44335530 | 217137 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 520 | 9 | 1 | 7 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| CHEMBL318605 | 217137 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 520 | 9 | 1 | 7 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| 133031 | 201002 | 20 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00050a002 | |||
| CHEMBL293511 | 201002 | 20 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00050a002 | |||
| 10439837 | 40242 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL122917 | 40242 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10462683 | 232332 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331507 | 232332 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44377058 | 238700 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 554 | 16 | 3 | 6 | 5.8 | CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)O)cnc2CCCC)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL350121 | 238700 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 554 | 16 | 3 | 6 | 5.8 | CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)O)cnc2CCCC)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10349512 | 474861 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 670 | 11 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97332 | 474861 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 670 | 11 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NS(=O)(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 44314761 | 202910 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL305647 | 202910 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 9853391 | 235722 | 1 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm9504722 | |||
| CHEMBL338027 | 235722 | 1 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm9504722 | |||
| 133031 | 201002 | 20 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL293511 | 201002 | 20 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| 10439837 | 40242 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL122917 | 40242 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10462683 | 232332 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL331507 | 232332 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10010234 | 198697 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL275552 | 198697 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10100951 | 234033 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL334300 | 234033 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| 9987614 | 333243 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 747 | 12 | 2 | 8 | 7.9 | CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL435792 | 333243 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 747 | 12 | 2 | 8 | 7.9 | CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10100951 | 234033 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL334300 | 234033 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| 10259468 | 237279 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL341369 | 237279 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10390872 | 235072 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 490 | 7 | 1 | 6 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 | 10.1021/jm00050a002 | |||
| CHEMBL335778 | 235072 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 490 | 7 | 1 | 6 | 4.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 | 10.1021/jm00050a002 | |||
| 10100951 | 234033 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL334300 | 234033 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| 10259468 | 237279 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL341369 | 237279 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 9895635 | 221511 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL328941 | 221511 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2occc2C)cc1 | 10.1021/jm00043a020 | |||
| 10010234 | 198697 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL275552 | 198697 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10100951 | 234033 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL334300 | 234033 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| 9987614 | 333243 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 747 | 12 | 2 | 8 | 7.9 | CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL435792 | 333243 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 747 | 12 | 2 | 8 | 7.9 | CCCCc1nn(-c2cc(NC(=O)CC(C)(C)C)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44381402 | 121946 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 647 | 12 | 2 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169967 | 121946 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 647 | 12 | 2 | 8 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10100951 | 234033 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL334300 | 234033 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| 10259468 | 237279 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL341369 | 237279 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10101606 | 39661 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122273 | 39661 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10259447 | 40809 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL125280 | 40809 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1007/s00044-011-9815-x | |||
| 10101606 | 39661 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122273 | 39661 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10259447 | 40809 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL125280 | 40809 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | |||
| 10326942 | 221878 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 652 | 10 | 1 | 8 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc(C)cc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329693 | 221878 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 652 | 10 | 1 | 8 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc(C)cc2C)cc1 | 10.1021/jm00043a020 | |||
| 10417102 | 474337 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 676 | 10 | 1 | 9 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)SCCS2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94145 | 474337 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 676 | 10 | 1 | 9 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)SCCS2)cc1 | 10.1021/jm00043a020 | |||
| 10101606 | 39661 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122273 | 39661 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10259447 | 40809 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL125280 | 40809 | 0 | None | None | None | Rabbit | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1007/s00044-011-9815-x | |||
| 10033136 | 39963 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122380 | 39963 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10033136 | 39963 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122380 | 39963 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44315078 | 469641 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74556 | 469641 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10033136 | 39963 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122380 | 39963 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10009984 | 222636 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL331455 | 222636 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10440144 | 235770 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL338342 | 235770 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10009984 | 222636 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331455 | 222636 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10440144 | 235770 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338342 | 235770 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 15292113 | 196389 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL259843 | 196389 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 9895984 | 469634 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74476 | 469634 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| 9895984 | 469634 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1021/jm9504722 | |||
| CHEMBL74476 | 469634 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1021/jm9504722 | |||
| 44381657 | 121841 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 633 | 13 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169488 | 121841 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 633 | 13 | 3 | 8 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)NCC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 9895984 | 469634 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL74476 | 469634 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10009984 | 222636 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL331455 | 222636 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10440144 | 235770 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL338342 | 235770 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10372497 | 237542 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 692 | 11 | 1 | 9 | 6.3 | CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL341783 | 237542 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 692 | 11 | 1 | 9 | 6.3 | CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10259657 | 238151 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 781 | 14 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL344597 | 238151 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 781 | 14 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10259489 | 40800 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 745 | 11 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl | 10.1007/s00044-011-9815-x | |||
| CHEMBL125231 | 40800 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 745 | 11 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl | 10.1007/s00044-011-9815-x | |||
| 19939418 | 217882 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 733 | 13 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL319730 | 217882 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 733 | 13 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 10395335 | 235940 | 0 | None | None | None | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339256 | 235940 | 0 | None | None | None | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 10259489 | 40800 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 745 | 11 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl | 10.1021/jm00019a004 | |||
| CHEMBL125231 | 40800 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 745 | 11 | 2 | 9 | 7.1 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1Cl | 10.1021/jm00019a004 | |||
| 10372497 | 237542 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 692 | 11 | 1 | 9 | 6.3 | CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL341783 | 237542 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 692 | 11 | 1 | 9 | 6.3 | CCCCc1nn(-c2cc(C(=O)OC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10259657 | 238151 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 781 | 14 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL344597 | 238151 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 781 | 14 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NC(=O)CCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44210589 | 121383 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 619 | 11 | 3 | 8 | 5.4 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL168413 | 121383 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 619 | 11 | 3 | 8 | 5.4 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC(C)C)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44381403 | 121947 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 675 | 11 | 2 | 9 | 5.4 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169968 | 121947 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 675 | 11 | 2 | 9 | 5.4 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44210585 | 239059 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 647 | 14 | 3 | 8 | 6.2 | CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCCC)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL353615 | 239059 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 647 | 14 | 3 | 8 | 6.2 | CCCCNC(=O)Nc1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCCC)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10010207 | 63844 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 735 | 13 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL139041 | 63844 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 735 | 13 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10078780 | 235790 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL338433 | 235790 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10439819 | 334454 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL444065 | 334454 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 19754068 | 202793 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 643 | 13 | 2 | 7 | 7.2 | CCCC(=O)Nc1c(C)nc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL304946 | 202793 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 643 | 13 | 2 | 7 | 7.2 | CCCC(=O)Nc1c(C)nc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC3CCCC3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| 10078780 | 235790 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338433 | 235790 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10439819 | 334454 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL444065 | 334454 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10416475 | 474582 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 624 | 10 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccco2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL95579 | 474582 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 624 | 10 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccco2)cc1 | 10.1021/jm00043a020 | |||
| 10010207 | 63844 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 735 | 13 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL139041 | 63844 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 735 | 13 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)OCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44210590 | 121501 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 605 | 11 | 3 | 8 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL168490 | 121501 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 605 | 11 | 3 | 8 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(NC(=O)NC)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10439715 | 235899 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339040 | 235899 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 44309938 | 469219 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 619 | 14 | 2 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL71388 | 469219 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 619 | 14 | 2 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 10028545 | 44854 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 490 | 8 | 1 | 6 | 4.9 | CCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm00050a002 | |||
| CHEMBL131156 | 44854 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 490 | 8 | 1 | 6 | 4.9 | CCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm00050a002 | |||
| 10439715 | 235899 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339040 | 235899 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10055534 | 313361 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL407919 | 313361 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| 9875044 | 474882 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 674 | 10 | 1 | 8 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97446 | 474882 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 674 | 10 | 1 | 8 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| 10439715 | 235899 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339040 | 235899 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 11765560 | 39430 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL121872 | 39430 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 9987414 | 235913 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339113 | 235913 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 19430442 | 469105 | 0 | None | None | None | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 725 | 15 | 1 | 9 | 7.7 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70726 | 469105 | 0 | None | None | None | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 725 | 15 | 1 | 9 | 7.7 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 11765560 | 39430 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL121872 | 39430 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 9987414 | 235913 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339113 | 235913 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10100951 | 234033 | 0 | None | None | None | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL334300 | 234033 | 0 | None | None | None | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 667 | 11 | 2 | 9 | 6.3 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| 11765560 | 39430 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL121872 | 39430 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 9987414 | 235913 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL339113 | 235913 | 0 | None | None | None | Rabbit | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 9810305 | 198833 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL276674 | 198833 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| 9810305 | 198833 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL276674 | 198833 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| 9810305 | 198833 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL276674 | 198833 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 9810305 | 198833 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL276674 | 198833 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| 9810305 | 198833 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL276674 | 198833 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| 9810305 | 198833 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL276674 | 198833 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-011-9815-x | |||
| 10439993 | 238026 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 739 | 13 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL343634 | 238026 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 739 | 13 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 183134 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1016/S0960-894X(01)81148-3 | |||
| 3939 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL7550 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1016/S0960-894X(01)81148-3 | |||
| 44311675 | 202246 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 768 | 16 | 2 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL302579 | 202246 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 768 | 16 | 2 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311537 | 202414 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 726 | 15 | 1 | 9 | 8.1 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL303647 | 202414 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 726 | 15 | 1 | 9 | 8.1 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311454 | 202995 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 692 | 17 | 2 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306340 | 202995 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 692 | 17 | 2 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311185 | 213910 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 733 | 15 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL309790 | 213910 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 733 | 15 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311752 | 214571 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 725 | 15 | 1 | 9 | 7.7 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(C(=O)c3ccccc3)c2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL311018 | 214571 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 725 | 15 | 1 | 9 | 7.7 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(C(=O)c3ccccc3)c2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311736 | 469134 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 768 | 16 | 2 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70867 | 469134 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 768 | 16 | 2 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311557 | 469204 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 703 | 14 | 1 | 9 | 8.2 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL71286 | 469204 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 703 | 14 | 1 | 9 | 8.2 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 183134 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1016/j.bmc.2010.10.043 | |||
| 3939 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL7550 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1016/j.bmc.2010.10.043 | |||
| 183134 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm00057a009 | |||
| 3939 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm00057a009 | |||
| CHEMBL7550 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm00057a009 | |||
| 73353934 | 183431 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 469 | 9 | 2 | 4 | 6.4 | CCCC(=O)Nc1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435824 | 183431 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 469 | 9 | 2 | 4 | 6.4 | CCCC(=O)Nc1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | |||
| 183134 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1016/S0960-894X(01)81119-7 | |||
| 3939 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL7550 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1016/S0960-894X(01)81119-7 | |||
| 183134 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1016/S0960-894X(01)81115-X | |||
| 3939 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL7550 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1016/S0960-894X(01)81115-X | |||
| 183134 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm00050a002 | |||
| 3939 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm00050a002 | |||
| CHEMBL7550 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm00050a002 | |||
| 10326972 | 221748 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 654 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329099 | 221748 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 654 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCCCC2)cc1 | 10.1021/jm00043a020 | |||
| 133031 | 201002 | 20 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL293511 | 201002 | 20 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 44300826 | 413375 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 544 | 7 | 1 | 7 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL58291 | 413375 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 544 | 7 | 1 | 7 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 183134 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm00067a001 | |||
| 3939 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm00067a001 | |||
| CHEMBL7550 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm00067a001 | |||
| 44372744 | 105381 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 451 | 7 | 1 | 6 | 5.5 | CCCc1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1 | 10.1021/jm9504722 | |||
| CHEMBL158795 | 105381 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 451 | 7 | 1 | 6 | 5.5 | CCCc1ccc(-c2nn[nH]n2)c(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c1 | 10.1021/jm9504722 | |||
| 9807029 | 468150 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 530 | 11 | 3 | 7 | 4.4 | CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 | 10.1021/jm9504722 | |||
| CHEMBL63998 | 468150 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 530 | 11 | 3 | 7 | 4.4 | CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(=O)O)cc1 | 10.1021/jm9504722 | |||
| 44384389 | 257752 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 572 | 2 | 2 | 7 | 5.6 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL367569 | 257752 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 572 | 2 | 2 | 7 | 5.6 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3 | 10.1016/0960-894X(96)00116-3 | |||
| 183134 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm9504722 | |||
| 3939 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm9504722 | |||
| CHEMBL7550 | 7963 | 16 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm9504722 | |||
| 10439993 | 238026 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 739 | 13 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL343634 | 238026 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 739 | 13 | 2 | 8 | 8.1 | CCCCc1nn(-c2cc(NCc3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 19102786 | 474102 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 648 | 9 | 1 | 8 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL92533 | 474102 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 648 | 9 | 1 | 8 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10032583 | 26618 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 690 | 10 | 1 | 8 | 7.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1185398 | 26618 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 690 | 10 | 1 | 8 | 7.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc3ccccc3s2)cc1 | 10.1021/jm00043a020 | |||
| 10054708 | 216796 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 626 | 10 | 1 | 7 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316273 | 216796 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 626 | 10 | 1 | 7 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCC2)cc1 | 10.1021/jm00043a020 | |||
| 10462598 | 233158 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL332909 | 233158 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1F | 10.1021/jm00019a004 | |||
| 10032820 | 236152 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339672 | 236152 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 7.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 44381552 | 238956 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 649 | 13 | 3 | 9 | 5.0 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCOC)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352629 | 238956 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 649 | 13 | 3 | 9 | 5.0 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCOC)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 9917399 | 202238 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 639 | 12 | 2 | 8 | 6.8 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL302519 | 202238 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 639 | 12 | 2 | 8 | 6.8 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| 9917399 | 202238 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 639 | 12 | 2 | 8 | 6.8 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C | 10.1021/jm9504722 | |||
| CHEMBL302519 | 202238 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 639 | 12 | 2 | 8 | 6.8 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)OCc3ccccc3)cc2)c1C | 10.1021/jm9504722 | |||
| 1610 | 7967 | 67 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| 3941 | 7967 | 67 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| 3961 | 7967 | 67 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| 44381553 | 239000 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 675 | 13 | 2 | 8 | 6.8 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352947 | 239000 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 675 | 13 | 2 | 8 | 6.8 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 136052288 | 252507 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 568 | 8 | 1 | 8 | 5.2 | CCc1cc2c(=O)n(CCc3ccc(F)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640122 | 252507 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 568 | 8 | 1 | 8 | 5.2 | CCc1cc2c(=O)n(CCc3ccc(F)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 10101351 | 333323 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL436396 | 333323 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 71652854 | 180013 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 593 | 11 | 2 | 7 | 5.9 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2366020 | 180013 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 593 | 11 | 2 | 7 | 5.9 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 10101351 | 333323 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL436396 | 333323 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 19430462 | 203034 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 735 | 16 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306638 | 203034 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 735 | 16 | 1 | 9 | 8.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 3542 | 484387 | 24 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.ejmech.2013.01.044 | |||
| CHEMBL938 | 484387 | 24 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.ejmech.2013.01.044 | |||
| 14971698 | 474196 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2ccccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1039/d2md00206j | |||
| CHEMBL93226 | 474196 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 512 | 9 | 2 | 6 | 6.0 | CCCCc1nn(-c2ccccc2Cl)c(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1039/d2md00206j | |||
| 10101351 | 333323 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL436396 | 333323 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10032342 | 474876 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 662 | 10 | 1 | 9 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2SCCS2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97394 | 474876 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 662 | 10 | 1 | 9 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2SCCS2)cc1 | 10.1021/jm00043a020 | |||
| 44381426 | 238941 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 666 | 12 | 2 | 8 | 6.8 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352502 | 238941 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 666 | 12 | 2 | 8 | 6.8 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10101351 | 333323 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL436396 | 333323 | 0 | None | None | None | Rabbit | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.2 | CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10373120 | 236442 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL340078 | 236442 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| 10373120 | 236442 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL340078 | 236442 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 19939398 | 216964 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 626 | 10 | 1 | 7 | 6.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL317547 | 216964 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 626 | 10 | 1 | 7 | 6.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10372718 | 218163 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 722 | 10 | 1 | 7 | 7.4 | O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1Cl | 10.1021/jm00043a020 | |||
| CHEMBL320222 | 218163 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 722 | 10 | 1 | 7 | 7.4 | O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1Cl | 10.1021/jm00043a020 | |||
| 10259447 | 40809 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL125280 | 40809 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 741 | 12 | 2 | 8 | 6.9 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1021/jm00019a004 | |||
| 44381656 | 238938 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 656 | 12 | 2 | 9 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccco3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL352458 | 238938 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 656 | 12 | 2 | 9 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccco3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10373120 | 236442 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL340078 | 236442 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1007/s00044-011-9815-x | |||
| 10440203 | 237767 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 773 | 13 | 2 | 8 | 8.5 | CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL342492 | 237767 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 773 | 13 | 2 | 8 | 8.5 | CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 11765454 | 236896 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL340473 | 236896 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 44310069 | 468728 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 617 | 16 | 2 | 7 | 7.0 | CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL67801 | 468728 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 617 | 16 | 2 | 7 | 7.0 | CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3cc(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 11765454 | 236896 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL340473 | 236896 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10349597 | 221113 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 680 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2(Cl)Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL328434 | 221113 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 680 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2(Cl)Cl)cc1 | 10.1021/jm00043a020 | |||
| 10440203 | 237767 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 773 | 13 | 2 | 8 | 8.5 | CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL342492 | 237767 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 773 | 13 | 2 | 8 | 8.5 | CCCCc1nn(-c2ccc(NCc3ccccc3)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 11765454 | 236896 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL340473 | 236896 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10259525 | 39510 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL122158 | 39510 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10349897 | 233443 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL333224 | 233443 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10101690 | 235744 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL338137 | 235744 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10010071 | 236196 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339722 | 236196 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10259525 | 39510 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL122158 | 39510 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10349897 | 233443 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL333224 | 233443 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10101690 | 235744 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338137 | 235744 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10259525 | 39510 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL122158 | 39510 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10349897 | 233443 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL333224 | 233443 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10101690 | 235744 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL338137 | 235744 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 44328276 | 222204 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 664 | 10 | 1 | 7 | 6.5 | C=C1C2CCC(C2)C1C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330464 | 222204 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 664 | 10 | 1 | 7 | 6.5 | C=C1C2CCC(C2)C1C(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| 44381622 | 121805 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 689 | 12 | 2 | 9 | 5.8 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169279 | 121805 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 689 | 12 | 2 | 9 | 5.8 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44311619 | 203119 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 756 | 16 | 2 | 8 | 8.8 | CCCc1nc(CC)c(C(=O)NCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL307359 | 203119 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 756 | 16 | 2 | 8 | 8.8 | CCCc1nc(CC)c(C(=O)NCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311683 | 215311 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 789 | 16 | 1 | 10 | 7.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL312301 | 215311 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 789 | 16 | 1 | 10 | 7.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311453 | 468991 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 678 | 17 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)NCCCOc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL69839 | 468991 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 678 | 17 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)NCCCOc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 73347892 | 183430 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 455 | 8 | 2 | 4 | 6.1 | CCCc1nc2c(C)cc(NC(=O)CC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435823 | 183430 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 455 | 8 | 2 | 4 | 6.1 | CCCc1nc2c(C)cc(NC(=O)CC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 172198 | 866 | 40 | None | None | None | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm7011563 | |||
| 2504 | 866 | 40 | None | None | None | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm7011563 | |||
| 5272 | 866 | 40 | None | None | None | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm7011563 | |||
| CHEMBL408403 | 866 | 40 | None | None | None | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm7011563 | |||
| DB11842 | 866 | 40 | None | None | None | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm7011563 | |||
| P01015 | 866 | 40 | None | None | None | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm7011563 | |||
| P01019 | 866 | 40 | None | None | None | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm7011563 | |||
| P11859 | 866 | 40 | None | None | None | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm7011563 | |||
| 183134 | 7963 | 16 | None | None | None | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm7011563 | |||
| 3939 | 7963 | 16 | None | None | None | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm7011563 | |||
| CHEMBL7550 | 7963 | 16 | None | None | None | Rat | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm7011563 | |||
| 3542 | 484387 | 24 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.bmc.2016.03.006 | |||
| CHEMBL938 | 484387 | 24 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.bmc.2016.03.006 | |||
| 3542 | 484387 | 24 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.bmc.2016.11.014 | |||
| CHEMBL938 | 484387 | 24 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.bmc.2016.11.014 | |||
| 10394995 | 220898 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 702 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Br)o2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL327191 | 220898 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 702 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Br)o2)cc1 | 10.1021/jm00043a020 | |||
| 10326775 | 221726 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C)o2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329089 | 221726 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C)o2)cc1 | 10.1021/jm00043a020 | |||
| 10010047 | 474811 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 712 | 10 | 1 | 7 | 7.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Br)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97020 | 474811 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 712 | 10 | 1 | 7 | 7.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Br)cc1 | 10.1021/jm00043a020 | |||
| 10439819 | 334454 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL444065 | 334454 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 5.5 | CCCCc1nn(-c2cc(C(=O)NCCOC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44384870 | 122822 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 541 | 8 | 2 | 7 | 5.5 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL173643 | 122822 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 541 | 8 | 2 | 7 | 5.5 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| 10010311 | 64174 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 12 | 2 | 8 | 7.8 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL139325 | 64174 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 12 | 2 | 8 | 7.8 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10417144 | 66602 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 679 | 11 | 1 | 9 | 6.4 | CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL141592 | 66602 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 679 | 11 | 1 | 9 | 6.4 | CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10462573 | 235874 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338889 | 235874 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10032988 | 235791 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338434 | 235791 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10462573 | 235874 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338889 | 235874 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10078132 | 216887 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 664 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2OC)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316904 | 216887 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 664 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2OC)cc1 | 10.1021/jm00043a020 | |||
| 3542 | 484387 | 24 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/acschembio.7b00481 | |||
| CHEMBL938 | 484387 | 24 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/acschembio.7b00481 | |||
| 10010311 | 64174 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 12 | 2 | 8 | 7.8 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL139325 | 64174 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 753 | 12 | 2 | 8 | 7.8 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10417144 | 66602 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 679 | 11 | 1 | 9 | 6.4 | CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL141592 | 66602 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 679 | 11 | 1 | 9 | 6.4 | CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10462573 | 235874 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338889 | 235874 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 11765541 | 237786 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL342605 | 237786 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10032988 | 235791 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338434 | 235791 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10032988 | 235791 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338434 | 235791 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10077743 | 474815 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97068 | 474815 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 | 10.1021/jm00043a020 | |||
| 11765541 | 237786 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL342605 | 237786 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 739 | 12 | 2 | 8 | 7.2 | CCCCc1nn(-c2ccc(NC(=O)CC)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10032988 | 235791 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338434 | 235791 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 9939191 | 199181 | 1 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL279629 | 199181 | 1 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1007/s00044-013-0831-x | |||
| 9939191 | 199181 | 1 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL279629 | 199181 | 1 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 9939191 | 199181 | 1 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL279629 | 199181 | 1 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00019a004 | |||
| 9939191 | 199181 | 1 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL279629 | 199181 | 1 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10349659 | 221041 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 688 | 10 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc3ccccc3c2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL327988 | 221041 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 688 | 10 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2oc3ccccc3c2C)cc1 | 10.1021/jm00043a020 | |||
| 10395335 | 235940 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339256 | 235940 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 757 | 12 | 2 | 8 | 7.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 10259468 | 237279 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL341369 | 237279 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.9 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 9939191 | 199181 | 1 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL279629 | 199181 | 1 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00052a006 | |||
| 9852499 | 239110 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 647 | 11 | 3 | 8 | 6.1 | CCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL354080 | 239110 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 647 | 11 | 3 | 8 | 6.1 | CCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10032877 | 39442 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL121907 | 39442 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10259841 | 40048 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122401 | 40048 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10032877 | 39442 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL121907 | 39442 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10259841 | 40048 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122401 | 40048 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10372451 | 236142 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339605 | 236142 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10032877 | 39442 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL121907 | 39442 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10259841 | 40048 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122401 | 40048 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 9830680 | 200791 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL292150 | 200791 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| 9830680 | 200791 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL292150 | 200791 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 9830680 | 200791 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL292150 | 200791 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10009984 | 222636 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331455 | 222636 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 705 | 12 | 2 | 9 | 6.4 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)cc1F | 10.1021/jm00019a004 | |||
| 9830680 | 200791 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm9504722 | |||
| CHEMBL292150 | 200791 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm9504722 | |||
| 9830680 | 200791 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL292150 | 200791 | 0 | None | None | None | Rabbit | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 630 | 9 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| 44312565 | 469654 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 437 | 9 | 3 | 6 | 3.1 | CC(O)CCC(=O)N(c1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)O)C(C)C | 10.1021/jm0204237 | |||
| CHEMBL74767 | 469654 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 437 | 9 | 3 | 6 | 3.1 | CC(O)CCC(=O)N(c1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)O)C(C)C | 10.1021/jm0204237 | |||
| 44348153 | 236803 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 591 | 13 | 1 | 6 | 8.6 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Oc2ccccc2)c1 | 10.1021/jm00075a033 | |||
| CHEMBL340367 | 236803 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 591 | 13 | 1 | 6 | 8.6 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Oc2ccccc2)c1 | 10.1021/jm00075a033 | |||
| 72548703 | 317107 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | |||
| CHEMBL4128926 | 317107 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | |||
| 10009968 | 222030 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329942 | 222030 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1 | 10.1021/jm00043a020 | |||
| 2583 | 8231 | 75 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2012.11.088 | |||
| 592 | 8231 | 75 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2012.11.088 | |||
| 65999 | 8231 | 75 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL1017 | 8231 | 75 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2012.11.088 | |||
| DB00966 | 8231 | 75 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2012.11.088 | |||
| 2583 | 8231 | 75 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm200409s | |||
| 592 | 8231 | 75 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm200409s | |||
| 65999 | 8231 | 75 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm200409s | |||
| CHEMBL1017 | 8231 | 75 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm200409s | |||
| DB00966 | 8231 | 75 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm200409s | |||
| 10007362 | 40140 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 536 | 12 | 2 | 8 | 4.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10030110 | 40140 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 536 | 12 | 2 | 8 | 4.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122443 | 40140 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 536 | 12 | 2 | 8 | 4.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125725 | 40140 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 536 | 12 | 2 | 8 | 4.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10254585 | 40267 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 480 | 13 | 1 | 5 | 5.2 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10480309 | 40267 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 480 | 13 | 1 | 5 | 5.2 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122969 | 40267 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 480 | 13 | 1 | 5 | 5.2 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331042 | 40267 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 480 | 13 | 1 | 5 | 5.2 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44311182 | 203077 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 703 | 14 | 1 | 9 | 8.2 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cccs2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL307008 | 203077 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 703 | 14 | 1 | 9 | 8.2 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cccs2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311452 | 469406 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 739 | 15 | 1 | 9 | 7.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL72595 | 469406 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 739 | 15 | 1 | 9 | 7.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 9940350 | 469643 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL74573 | 469643 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44275095 | 195551 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 536 | 9 | 3 | 7 | 5.2 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25585 | 195551 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 536 | 9 | 3 | 7 | 5.2 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44309704 | 469200 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 612 | 13 | 1 | 7 | 7.7 | CCCCC(=O)N(Cc1ccccc1)c1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2nc1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL71253 | 469200 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 612 | 13 | 1 | 7 | 7.7 | CCCCC(=O)N(Cc1ccccc1)c1cc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2nc1C | 10.1016/S0960-894X(01)81115-X | |||
| 183134 | 7963 | 16 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1016/S0960-894X(00)80044-X | |||
| 3939 | 7963 | 16 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1016/S0960-894X(00)80044-X | |||
| CHEMBL7550 | 7963 | 16 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1016/S0960-894X(00)80044-X | |||
| 9939191 | 199181 | 1 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL279629 | 199181 | 1 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 44379268 | 238744 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 666 | 11 | 1 | 8 | 6.4 | CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL350554 | 238744 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 666 | 11 | 1 | 8 | 6.4 | CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44377125 | 118461 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 545 | 10 | 1 | 7 | 5.0 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL162148 | 118461 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 545 | 10 | 1 | 7 | 5.0 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10032851 | 40718 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL124771 | 40718 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 11765177 | 235873 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338888 | 235873 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 19939753 | 468743 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 605 | 13 | 2 | 8 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL67921 | 468743 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 605 | 13 | 2 | 8 | 6.4 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 11765177 | 235873 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338888 | 235873 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 11765177 | 235873 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338888 | 235873 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 44315144 | 196928 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL263191 | 196928 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10439858 | 40743 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL124903 | 40743 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 18950609 | 40293 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1Cl | 10.1021/jm00075a033 | |||
| CHEMBL123084 | 40293 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1Cl | 10.1021/jm00075a033 | |||
| 10439858 | 40743 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL124903 | 40743 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10439858 | 40743 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL124903 | 40743 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 183134 | 7963 | 16 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm00075a033 | |||
| 3939 | 7963 | 16 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm00075a033 | |||
| CHEMBL7550 | 7963 | 16 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm00075a033 | |||
| 44315282 | 196958 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL263452 | 196958 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| 14971639 | 233154 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 512 | 9 | 2 | 6 | 6.1 | CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1039/d2md00206j | |||
| CHEMBL332897 | 233154 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 512 | 9 | 2 | 6 | 6.1 | CCCCc1nc(-c2ccccc2Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1039/d2md00206j | |||
| 9939191 | 199181 | 1 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL279629 | 199181 | 1 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 10101608 | 235894 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL339004 | 235894 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 751 | 14 | 2 | 8 | 7.2 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44381425 | 239104 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 681 | 12 | 3 | 8 | 7.2 | CCCc1nc2ccc(NC(=O)Nc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL353980 | 239104 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 681 | 12 | 3 | 8 | 7.2 | CCCc1nc2ccc(NC(=O)Nc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10032193 | 237922 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 649 | 10 | 2 | 8 | 6.1 | CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL342843 | 237922 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 649 | 10 | 2 | 8 | 6.1 | CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10394829 | 238119 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 683 | 10 | 2 | 8 | 6.5 | CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL344387 | 238119 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 683 | 10 | 2 | 8 | 6.5 | CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10417321 | 39509 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122157 | 39509 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10417321 | 39509 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122157 | 39509 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10438745 | 216854 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316655 | 216854 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2C)cc1 | 10.1021/jm00043a020 | |||
| 10258694 | 222066 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 648 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330165 | 222066 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 648 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2C)cc1 | 10.1021/jm00043a020 | |||
| 10010071 | 236196 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339722 | 236196 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 715 | 13 | 2 | 10 | 6.1 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10032193 | 237922 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 649 | 10 | 2 | 8 | 6.1 | CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL342843 | 237922 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 649 | 10 | 2 | 8 | 6.1 | CCCCc1nn(-c2cc(N)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10394829 | 238119 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 683 | 10 | 2 | 8 | 6.5 | CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL344387 | 238119 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 683 | 10 | 2 | 8 | 6.5 | CCCCc1nn(-c2ccc(N)cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10417321 | 39509 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL122157 | 39509 | 0 | None | None | None | Rabbit | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 19430475 | 469176 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 787 | 16 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL71125 | 469176 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 787 | 16 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 9874508 | 469570 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL73876 | 469570 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 9874508 | 469570 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1021/jm9504722 | |||
| CHEMBL73876 | 469570 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1021/jm9504722 | |||
| 3542 | 484387 | 24 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.bmc.2010.07.034 | |||
| CHEMBL938 | 484387 | 24 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.bmc.2010.07.034 | |||
| 44274855 | 197266 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 564 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(N(C)C(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL26614 | 197266 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 564 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(N(C)C(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 9960852 | 216823 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 630 | 12 | 1 | 8 | 6.3 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316482 | 216823 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 630 | 12 | 1 | 8 | 6.3 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| 10007362 | 40140 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 536 | 12 | 2 | 8 | 4.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10030110 | 40140 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 536 | 12 | 2 | 8 | 4.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122443 | 40140 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 536 | 12 | 2 | 8 | 4.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125725 | 40140 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 536 | 12 | 2 | 8 | 4.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10256602 | 40748 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 534 | 12 | 1 | 6 | 5.9 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C)s2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL124925 | 40748 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 534 | 12 | 1 | 6 | 5.9 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C)s2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10052399 | 41830 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 520 | 12 | 1 | 6 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10414338 | 41830 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 520 | 12 | 1 | 6 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL126111 | 41830 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 520 | 12 | 1 | 6 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL341295 | 41830 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 520 | 12 | 1 | 6 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44311617 | 202606 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 679 | 13 | 1 | 9 | 6.7 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL304065 | 202606 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 679 | 13 | 1 | 9 | 6.7 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311618 | 328321 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 772 | 16 | 2 | 8 | 7.8 | CCCc1nc(CC)c(C(=O)NCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL419073 | 328321 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 772 | 16 | 2 | 8 | 7.8 | CCCc1nc(CC)c(C(=O)NCc2ccccc2[S+]([O-])c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 19430479 | 469192 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL71220 | 469192 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311184 | 469326 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 727 | 16 | 1 | 9 | 8.6 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2Oc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL72099 | 469326 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 727 | 16 | 1 | 9 | 8.6 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2Oc2ccccc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311558 | 469607 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 731 | 15 | 1 | 9 | 8.8 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccsc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL74236 | 469607 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 731 | 15 | 1 | 9 | 8.8 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccsc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 3542 | 484387 | 24 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.bmc.2013.03.016 | |||
| CHEMBL938 | 484387 | 24 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.bmc.2013.03.016 | |||
| 44309902 | 203167 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 598 | 12 | 1 | 7 | 7.4 | CCCCc1nc2c(C)c(N(CCCC)C(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL307757 | 203167 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 598 | 12 | 1 | 7 | 7.4 | CCCCc1nc2c(C)c(N(CCCC)C(=O)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 44309703 | 337071 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2cc(NC(=O)N(c3ccccc3)c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL448476 | 337071 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2cc(NC(=O)N(c3ccccc3)c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 44309903 | 469301 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL71925 | 469301 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 10010027 | 474885 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 710 | 11 | 1 | 7 | 7.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2-c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97465 | 474885 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 710 | 11 | 1 | 7 | 7.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2-c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 44309903 | 469301 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL71925 | 469301 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 8.3 | CCCCc1nc2c(C)c(NC(=O)N(c3ccccc3)c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| 10372810 | 215881 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 735 | 13 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL313868 | 215881 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 735 | 13 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 15292111 | 469630 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74442 | 469630 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10485202 | 238178 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 747 | 14 | 1 | 8 | 7.4 | CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL344811 | 238178 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 747 | 14 | 1 | 8 | 7.4 | CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10485202 | 238178 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 747 | 14 | 1 | 8 | 7.4 | CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL344811 | 238178 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 747 | 14 | 1 | 8 | 7.4 | CCCCc1nn(-c2cc(C(=O)N(C)CCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 1952 | 4504 | 2 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F | 10.1021/jm00043a020 | |||
| 5312129 | 4504 | 2 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F | 10.1021/jm00043a020 | |||
| CHEMBL1182768 | 4504 | 2 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(c(=O)n1Cc1ccc(cc1)c1ccccc1S(=O)(=O)NC(=O)c1ccc(s1)C)c1ccccc1C(F)(F)F | 10.1021/jm00043a020 | |||
| 9874086 | 218694 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL321367 | 218694 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2(F)F)cc1 | 10.1021/jm00043a020 | |||
| 10439715 | 235899 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339040 | 235899 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 699 | 12 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(C(=O)NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 3542 | 484387 | 24 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/jm8007618 | |||
| CHEMBL938 | 484387 | 24 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/jm8007618 | |||
| 10350378 | 475036 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 796 | 10 | 1 | 8 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Br)sc2Br)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL98453 | 475036 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 796 | 10 | 1 | 8 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Br)sc2Br)cc1 | 10.1021/jm00043a020 | |||
| 10028460 | 235435 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 488 | 7 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00050a002 | |||
| CHEMBL336180 | 235435 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 488 | 7 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00050a002 | |||
| 10009478 | 221956 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 652 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329858 | 221956 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 652 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 | 10.1021/jm00043a020 | |||
| 2541 | 7891 | 68 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 6907 | 7891 | 68 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL1016 | 7891 | 68 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 10052399 | 41830 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 520 | 12 | 1 | 6 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10414338 | 41830 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 520 | 12 | 1 | 6 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL126111 | 41830 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 520 | 12 | 1 | 6 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL341295 | 41830 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 520 | 12 | 1 | 6 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9824776 | 238124 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 445 | 5 | 1 | 6 | 4.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NOS(=O)N2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL344407 | 238124 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 445 | 5 | 1 | 6 | 4.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NOS(=O)N2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 60148656 | 183436 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 457 | 7 | 2 | 5 | 5.9 | CCCc1nc2c(C)cc(NC(=O)OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435829 | 183436 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 457 | 7 | 2 | 5 | 5.9 | CCCc1nc2c(C)cc(NC(=O)OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 9824776 | 238124 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 445 | 5 | 1 | 6 | 4.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NOS(=O)N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL344407 | 238124 | 0 | None | None | None | Rabbit | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 445 | 5 | 1 | 6 | 4.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NOS(=O)N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 15292113 | 196389 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL259843 | 196389 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 693 | 11 | 2 | 9 | 5.5 | CCCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10349801 | 217564 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL319353 | 217564 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2Cl)cc1 | 10.1021/jm00043a020 | |||
| 10417431 | 218689 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 718 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Br)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL321363 | 218689 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 718 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2Br)cc1 | 10.1021/jm00043a020 | |||
| 10101606 | 39661 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122273 | 39661 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 751 | 12 | 2 | 8 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 172198 | 866 | 40 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| 2504 | 866 | 40 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| 5272 | 866 | 40 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL408403 | 866 | 40 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| DB11842 | 866 | 40 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| P01015 | 866 | 40 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| P01019 | 866 | 40 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| P11859 | 866 | 40 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| 15292112 | 202998 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL306361 | 202998 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 14956763 | 328375 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 526 | 10 | 1 | 10 | 4.2 | CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL419483 | 328375 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 526 | 10 | 1 | 10 | 4.2 | CCCCc1nn(-c2ccc(OC)cc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 19430458 | 469021 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 769 | 16 | 1 | 9 | 8.4 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70100 | 469021 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 769 | 16 | 1 | 9 | 8.4 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCc2ccccc2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 18950608 | 39561 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(C)c1 | 10.1021/jm00075a033 | |||
| CHEMBL122224 | 39561 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(C)c1 | 10.1021/jm00075a033 | |||
| 10032361 | 222203 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 664 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(OC)cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330463 | 222203 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 664 | 11 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(OC)cc2)cc1 | 10.1021/jm00043a020 | |||
| 9987414 | 235913 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL339113 | 235913 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44275095 | 195551 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 536 | 9 | 3 | 7 | 5.2 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25585 | 195551 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 536 | 9 | 3 | 7 | 5.2 | CCCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 18950586 | 39456 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Cl)c1 | 10.1021/jm00075a033 | |||
| CHEMBL122017 | 39456 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(Cl)c1 | 10.1021/jm00075a033 | |||
| 9986299 | 314323 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 616 | 12 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL409058 | 314323 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 616 | 12 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC)cc1 | 10.1021/jm00043a020 | |||
| 10349392 | 474902 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 659 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C#N)cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97557 | 474902 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 659 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C#N)cc2)cc1 | 10.1021/jm00043a020 | |||
| 10372659 | 236917 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL340632 | 236917 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 713 | 13 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 135955119 | 252514 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640129 | 252514 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 53321879 | 120392 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 470 | 8 | 1 | 5 | 5.8 | CCCCC1=N[C@](C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1667998 | 120392 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 470 | 8 | 1 | 5 | 5.8 | CCCCC1=N[C@](C)(C2CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 44315304 | 469877 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL76821 | 469877 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 73349224 | 182984 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 626 | 9 | 1 | 11 | 4.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)n2cnnn2)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL2425239 | 182984 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 626 | 9 | 1 | 11 | 4.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)n2cnnn2)cc1 | 10.1007/s00044-013-0831-x | |||
| 14956757 | 139872 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL19018 | 139872 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 14956757 | 139872 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL19018 | 139872 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00043a020 | |||
| 14956757 | 139872 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL19018 | 139872 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00052a006 | |||
| 44311538 | 203013 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 699 | 14 | 1 | 10 | 6.9 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cncnc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306435 | 203013 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 699 | 14 | 1 | 10 | 6.9 | CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2cncnc2)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311183 | 469588 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 731 | 15 | 1 | 9 | 8.8 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2cccs2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL74069 | 469588 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 731 | 15 | 1 | 9 | 8.8 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2cccs2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311735 | 469637 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OC(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL74514 | 469637 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OC(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 9914666 | 235569 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 520 | 5 | 1 | 6 | 6.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL337086 | 235569 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 520 | 5 | 1 | 6 | 6.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2c(Cl)ccc(Cl)c2C(=O)O)c1 | 10.1016/j.bmc.2010.10.043 | |||
| 44272246 | 199032 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 628 | 11 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(=O)C(C)C)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL278305 | 199032 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 628 | 11 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(=O)C(C)C)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 44272247 | 199102 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(=O)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL278977 | 199102 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(=O)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 15076146 | 216631 | 0 | None | None | None | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 4.9 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL315104 | 216631 | 0 | None | None | None | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 423 | 6 | 1 | 6 | 4.9 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 44310586 | 337159 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.3 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| CHEMBL449648 | 337159 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.3 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| 10483888 | 220956 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL327563 | 220956 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 | 10.1021/jm00043a020 | |||
| 10416501 | 221894 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 626 | 9 | 1 | 7 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329759 | 221894 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 626 | 9 | 1 | 7 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| 10483726 | 474461 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 600 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94910 | 474461 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 600 | 10 | 1 | 7 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)C)cc1 | 10.1021/jm00043a020 | |||
| 183134 | 7963 | 16 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1016/S0960-894X(01)81145-8 | |||
| 3939 | 7963 | 16 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL7550 | 7963 | 16 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1016/S0960-894X(01)81145-8 | |||
| 9961192 | 25644 | 35 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1179743 | 25644 | 35 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 654 | 10 | 1 | 8 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2sccc2C)cc1 | 10.1021/jm00043a020 | |||
| 10078554 | 235837 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338687 | 235837 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10078554 | 235837 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338687 | 235837 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10010125 | 474884 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 724 | 12 | 1 | 7 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cc2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97464 | 474884 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 724 | 12 | 1 | 7 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cc2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10078554 | 235837 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL338687 | 235837 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 44275096 | 195146 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 599 | 10 | 1 | 8 | 6.4 | CCCCc1nc2ccc(N(C)C(=O)OCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25315 | 195146 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 599 | 10 | 1 | 8 | 6.4 | CCCCc1nc2ccc(N(C)C(=O)OCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10259265 | 219585 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL323506 | 219585 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10259265 | 219585 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL323506 | 219585 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10077497 | 25647 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1179757 | 25647 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 612 | 10 | 1 | 7 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCC2)cc1 | 10.1021/jm00043a020 | |||
| 11765560 | 39430 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL121872 | 39430 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 743 | 12 | 2 | 9 | 6.3 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44314761 | 202910 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL305647 | 202910 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 701 | 11 | 3 | 7 | 6.6 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(CC)cc2F)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10394712 | 238135 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 671 | 12 | 2 | 8 | 6.2 | CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL344467 | 238135 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 671 | 12 | 2 | 8 | 6.2 | CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 14956739 | 473279 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87074 | 473279 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 10394712 | 238135 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 671 | 12 | 2 | 8 | 6.2 | CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL344467 | 238135 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 671 | 12 | 2 | 8 | 6.2 | CCCCc1nn(-c2cccc(NC(=O)CC)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44381528 | 121777 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 548 | 10 | 2 | 8 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(N)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169009 | 121777 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 548 | 10 | 2 | 8 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc(N)cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10032877 | 39442 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL121907 | 39442 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 733 | 12 | 2 | 9 | 6.6 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44314823 | 317396 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL415073 | 317396 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 679 | 13 | 2 | 8 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 10484866 | 65412 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 699 | 14 | 2 | 8 | 7.0 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL140619 | 65412 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 699 | 14 | 2 | 8 | 7.0 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| 9984181 | 237249 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 520 | 12 | 1 | 6 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccsc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL341131 | 237249 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 520 | 12 | 1 | 6 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccsc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277573 | 199740 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4cccnc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL283495 | 199740 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4cccnc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44277871 | 199891 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 599 | 10 | 1 | 9 | 5.8 | CCCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28464 | 199891 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 599 | 10 | 1 | 9 | 5.8 | CCCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 192626 | 39549 | 8 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 499 | 11 | 1 | 5 | 6.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1 | 10.1021/jm00075a033 | |||
| CHEMBL122212 | 39549 | 8 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 499 | 11 | 1 | 5 | 6.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1 | 10.1021/jm00075a033 | |||
| 1481 | 7955 | 73 | None | None | None | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)80526-6 | |||
| 3749 | 7955 | 73 | None | None | None | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)80526-6 | |||
| 6908 | 7955 | 73 | None | None | None | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL1513 | 7955 | 73 | None | None | None | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/S0960-894X(01)80526-6 | |||
| 44285267 | 295132 | 32 | None | None | None | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 414 | 6 | 1 | 5 | 4.4 | CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL39379 | 295132 | 32 | None | None | None | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 414 | 6 | 1 | 5 | 4.4 | CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 44274731 | 200243 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 498 | 8 | 1 | 7 | 4.4 | CCCCc1nc2ccc([S+](C)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL287184 | 200243 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 498 | 8 | 1 | 7 | 4.4 | CCCCc1nc2ccc([S+](C)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 70682146 | 157989 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058860 | 157989 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 10078800 | 218769 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL321531 | 218769 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 44311635 | 202313 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 581 | 10 | 2 | 9 | 4.3 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL302959 | 202313 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 581 | 10 | 2 | 9 | 4.3 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1F | 10.1016/S0960-894X(00)80076-1 | |||
| 10032988 | 235791 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338434 | 235791 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 747 | 13 | 2 | 9 | 7.6 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44385182 | 123835 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 637 | 10 | 3 | 7 | 5.7 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL176473 | 123835 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 637 | 10 | 3 | 7 | 5.7 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| 10484866 | 65412 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 699 | 14 | 2 | 8 | 7.0 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| CHEMBL140619 | 65412 | 0 | None | None | None | Rabbit | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 699 | 14 | 2 | 8 | 7.0 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1021/jm00052a006 | |||
| 10372550 | 329450 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL421478 | 329450 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10372550 | 329450 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL421478 | 329450 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10372550 | 329450 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL421478 | 329450 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 145946921 | 332370 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 592 | 11 | 1 | 7 | 5.5 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL4300967 | 332370 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 592 | 11 | 1 | 7 | 5.5 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 44314780 | 203127 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL307430 | 203127 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 14956772 | 215632 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 510 | 10 | 1 | 9 | 4.6 | CCCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL312913 | 215632 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 510 | 10 | 1 | 9 | 4.6 | CCCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 9830839 | 216587 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 640 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL314812 | 216587 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 640 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 | 10.1021/jm00043a020 | |||
| 10078780 | 235790 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338433 | 235790 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 749 | 13 | 2 | 10 | 6.4 | CCCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10373120 | 236442 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL340078 | 236442 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 791 | 12 | 2 | 8 | 8.0 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)ccc2Cl)cc1F | 10.1021/jm00019a004 | |||
| 44381739 | 121572 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL168771 | 121572 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 44274854 | 194724 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 537 | 9 | 2 | 8 | 5.1 | CCCCc1nc2ccc(OC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25056 | 194724 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 537 | 9 | 2 | 8 | 5.1 | CCCCc1nc2ccc(OC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44274731 | 200243 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 498 | 8 | 1 | 7 | 4.4 | CCCCc1nc2ccc([S+](C)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL287184 | 200243 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 498 | 8 | 1 | 7 | 4.4 | CCCCc1nc2ccc([S+](C)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10055448 | 64403 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL139582 | 64403 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 136052335 | 252510 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 622 | 8 | 1 | 8 | 5.8 | O=c1nc(-c2ccccc2-c2ccc(Cn3c(=O)n(CCc4cccc(F)c4)c(=O)c4cc(CC(F)(F)F)sc43)cc2)[nH]o1 | nan | |||
| CHEMBL3640125 | 252510 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 622 | 8 | 1 | 8 | 5.8 | O=c1nc(-c2ccccc2-c2ccc(Cn3c(=O)n(CCc4cccc(F)c4)c(=O)c4cc(CC(F)(F)F)sc43)cc2)[nH]o1 | nan | |||
| 136052364 | 252513 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 608 | 9 | 1 | 10 | 5.0 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640128 | 252513 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 608 | 9 | 1 | 10 | 5.0 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 135876075 | 252516 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 624 | 9 | 1 | 11 | 5.6 | COc1ccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3F)c2=O)cc1 | nan | |||
| CHEMBL3640131 | 252516 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 624 | 9 | 1 | 11 | 5.6 | COc1ccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3F)c2=O)cc1 | nan | |||
| 44311754 | 203047 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 757 | 16 | 1 | 9 | 9.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306761 | 203047 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 757 | 16 | 1 | 9 | 9.2 | CCCc1nc(CC)c(C(=O)OCc2ccccc2Sc2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311071 | 213151 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 8.0 | CCCCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2OC)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL308482 | 213151 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 707 | 18 | 1 | 9 | 8.0 | CCCCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2OC)c(F)c1 | 10.1016/S0960-894X(00)80077-3 | |||
| 10322211 | 334048 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 464 | 6 | 1 | 7 | 4.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(c1ccccc1)c1nnn[nH]1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL442963 | 334048 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 464 | 6 | 1 | 7 | 4.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)CCN2C(c1ccccc1)c1nnn[nH]1 | 10.1016/j.bmc.2010.10.043 | |||
| 15818748 | 200095 | 0 | None | None | None | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 543 | 9 | 1 | 5 | 5.7 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL286134 | 200095 | 0 | None | None | None | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 543 | 9 | 1 | 5 | 5.7 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 9850811 | 310767 | 0 | None | None | None | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 561 | 8 | 1 | 6 | 5.3 | CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL39996 | 310767 | 0 | None | None | None | Rat | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 561 | 8 | 1 | 6 | 5.3 | CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 2583 | 8231 | 75 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2013.08.014 | |||
| 592 | 8231 | 75 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2013.08.014 | |||
| 65999 | 8231 | 75 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL1017 | 8231 | 75 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2013.08.014 | |||
| DB00966 | 8231 | 75 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2013.08.014 | |||
| 2583 | 8231 | 75 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | |||
| 592 | 8231 | 75 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | |||
| 65999 | 8231 | 75 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1017 | 8231 | 75 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | |||
| DB00966 | 8231 | 75 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2012.01.009 | |||
| 2583 | 8231 | 75 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| 592 | 8231 | 75 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| 65999 | 8231 | 75 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL1017 | 8231 | 75 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| DB00966 | 8231 | 75 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| 19939454 | 474443 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 761 | 15 | 2 | 8 | 8.2 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4cc(CC)ccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL94793 | 474443 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 761 | 15 | 2 | 8 | 8.2 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4cc(CC)ccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1016/S0960-894X(01)80595-3 | |||
| 3036053 | 201463 | 12 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 409 | 6 | 1 | 6 | 4.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL296725 | 201463 | 12 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 409 | 6 | 1 | 6 | 4.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 9851889 | 202170 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL302102 | 202170 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)81115-X | |||
| 3036053 | 201463 | 12 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 409 | 6 | 1 | 6 | 4.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| CHEMBL296725 | 201463 | 12 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 409 | 6 | 1 | 6 | 4.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| 10417031 | 217009 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 669 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccnc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL317864 | 217009 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 669 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccnc2Cl)cc1 | 10.1021/jm00043a020 | |||
| 10439253 | 221807 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 652 | 10 | 1 | 8 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL329255 | 221807 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 652 | 10 | 1 | 8 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(C)oc2C)cc1 | 10.1021/jm00043a020 | |||
| 10439837 | 40242 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL122917 | 40242 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 717 | 12 | 2 | 8 | 6.8 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44348523 | 222635 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL331450 | 222635 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 723 | 12 | 2 | 8 | 6.1 | CCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10462683 | 232332 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331507 | 232332 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 735 | 12 | 2 | 10 | 6.0 | CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 9851082 | 201158 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 573 | 12 | 1 | 8 | 5.5 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm9504722 | |||
| CHEMBL294512 | 201158 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 573 | 12 | 1 | 8 | 5.5 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm9504722 | |||
| 44381739 | 121572 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL168771 | 121572 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 656 | 10 | 2 | 7 | 6.4 | CCCc1nc2ccc(NC(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| 3542 | 484387 | 24 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/jm701575k | |||
| CHEMBL938 | 484387 | 24 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/jm701575k | |||
| 10055448 | 64403 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL139582 | 64403 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.3 | CCCCc1nn(-c2cc(NCCC)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 136052282 | 252511 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 594 | 8 | 1 | 9 | 5.2 | O=C(Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(F)cc1 | nan | |||
| CHEMBL3640126 | 252511 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 594 | 8 | 1 | 9 | 5.2 | O=C(Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(F)cc1 | nan | |||
| 136052259 | 252517 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 606 | 9 | 1 | 11 | 5.5 | COc1cccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3)c2=O)c1 | nan | |||
| CHEMBL3640132 | 252517 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 606 | 9 | 1 | 11 | 5.5 | COc1cccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3)c2=O)c1 | nan | |||
| 44277676 | 199530 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 613 | 11 | 0 | 9 | 6.1 | CCCCCN(C(=O)c1ccccc1OC)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL282167 | 199530 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 613 | 11 | 0 | 9 | 6.1 | CCCCCN(C(=O)c1ccccc1OC)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 3936 | 4506 | 37 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116804 | |||
| 6603900 | 4506 | 37 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL288174 | 4506 | 37 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116804 | |||
| 44274692 | 196787 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 541 | 10 | 2 | 7 | 6.2 | CCCCc1nc2ccc(NCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL26217 | 196787 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 541 | 10 | 2 | 7 | 6.2 | CCCCc1nc2ccc(NCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 9955424 | 330028 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 450 | 7 | 1 | 6 | 4.9 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL422756 | 330028 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 450 | 7 | 1 | 6 | 4.9 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 127034873 | 270461 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735744 | 270461 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44379183 | 239441 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 571 | 10 | 1 | 6 | 6.2 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL355708 | 239441 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 571 | 10 | 1 | 6 | 6.2 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2(C)CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10461785 | 26197 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 639 | 10 | 1 | 9 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1182712 | 26197 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 639 | 10 | 1 | 9 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ocnc2C)cc1 | 10.1021/jm00043a020 | |||
| 10348847 | 222068 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 615 | 10 | 2 | 7 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330170 | 222068 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 615 | 10 | 2 | 7 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10484119 | 332837 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 628 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL432822 | 332837 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 628 | 10 | 1 | 7 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10054188 | 474410 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 592 | 9 | 1 | 7 | 5.1 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94582 | 474410 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 592 | 9 | 1 | 7 | 5.1 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| 10462933 | 40764 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL125008 | 40764 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 777 | 11 | 2 | 9 | 7.5 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 3936 | 4506 | 37 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm9504722 | |||
| 6603900 | 4506 | 37 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm9504722 | |||
| CHEMBL288174 | 4506 | 37 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/jm9504722 | |||
| 44381670 | 239129 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 657 | 11 | 3 | 9 | 6.0 | CCCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Oc2occc2C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL354298 | 239129 | 0 | None | None | None | Rabbit | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 657 | 11 | 3 | 9 | 6.0 | CCCCc1nc2ccc(NC(=O)NCC)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Oc2occc2C)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 10030086 | 40405 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 535 | 12 | 1 | 7 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10392378 | 40405 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 535 | 12 | 1 | 7 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL123671 | 40405 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 535 | 12 | 1 | 7 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125383 | 40405 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 535 | 12 | 1 | 7 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10325267 | 40745 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 550 | 12 | 1 | 9 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL124913 | 40745 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 550 | 12 | 1 | 9 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(N)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 14956757 | 139872 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL19018 | 139872 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 136052261 | 252509 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 618 | 8 | 1 | 8 | 5.9 | Cc1ccc(CCn2c(=O)c3cc(CC(F)(F)F)sc3n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2=O)cc1 | nan | |||
| CHEMBL3640124 | 252509 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 618 | 8 | 1 | 8 | 5.9 | Cc1ccc(CCn2c(=O)c3cc(CC(F)(F)F)sc3n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2=O)cc1 | nan | |||
| 136052281 | 252515 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 606 | 9 | 1 | 11 | 5.5 | COc1ccccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3noc(O)n3)cc2)c1=O | nan | |||
| CHEMBL3640130 | 252515 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 606 | 9 | 1 | 11 | 5.5 | COc1ccccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3noc(O)n3)cc2)c1=O | nan | |||
| 136052251 | 252526 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 544 | 7 | 1 | 9 | 4.5 | CCc1cc2c(=O)n(CC(=O)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640140 | 252526 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 544 | 7 | 1 | 9 | 4.5 | CCc1cc2c(=O)n(CC(=O)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052396 | 252544 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 610 | 6 | 1 | 9 | 5.7 | CCc1cc2c(=O)n(-c3ccc4c(c3)CC(C)(C)O4)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640158 | 252544 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 610 | 6 | 1 | 9 | 5.7 | CCc1cc2c(=O)n(-c3ccc4c(c3)CC(C)(C)O4)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 136052283 | 252545 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 556 | 7 | 1 | 9 | 4.8 | CC(C)(C)C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O | nan | |||
| CHEMBL3640159 | 252545 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 556 | 7 | 1 | 9 | 4.8 | CC(C)(C)C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O | nan | |||
| 44277677 | 199531 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 585 | 9 | 1 | 9 | 5.5 | CCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL282168 | 199531 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 585 | 9 | 1 | 9 | 5.5 | CCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 18950598 | 39435 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1C | 10.1021/jm00075a033 | |||
| CHEMBL121891 | 39435 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccccc1C | 10.1021/jm00075a033 | |||
| 73355475 | 183434 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 517 | 9 | 2 | 4 | 6.9 | CCCc1nc2c(C)cc(NC(=O)Cc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435827 | 183434 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 517 | 9 | 2 | 4 | 6.9 | CCCc1nc2c(C)cc(NC(=O)Cc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 14956757 | 139872 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL19018 | 139872 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 14956779 | 140932 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 445 | 8 | 1 | 7 | 4.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL19202 | 140932 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 445 | 8 | 1 | 7 | 4.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 10078048 | 216537 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 654 | 12 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL314514 | 216537 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 654 | 12 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1021/jm00043a020 | |||
| 9986951 | 474638 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL95955 | 474638 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)cc2)cc1 | 10.1021/jm00043a020 | |||
| 44314822 | 202999 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL306362 | 202999 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 6.7 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44315058 | 142697 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL194608 | 142697 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 9869504 | 474899 | 3 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 474 | 10 | 2 | 5 | 5.9 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c2ccccc12 | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL97533 | 474899 | 3 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 474 | 10 | 2 | 5 | 5.9 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c2ccccc12 | 10.1016/S0960-894X(01)81116-1 | |||
| 44274673 | 194157 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 451 | 7 | 2 | 7 | 4.2 | CCCCc1nc2ccc(N)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24724 | 194157 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 451 | 7 | 2 | 7 | 4.2 | CCCCc1nc2ccc(N)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10254585 | 40267 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 480 | 13 | 1 | 5 | 5.2 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10480309 | 40267 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 480 | 13 | 1 | 5 | 5.2 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122969 | 40267 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 480 | 13 | 1 | 5 | 5.2 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331042 | 40267 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 480 | 13 | 1 | 5 | 5.2 | CCCCc1ncc(/C=C2\C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 136052277 | 252539 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 656 | 10 | 1 | 11 | 5.3 | CCc1cc2c(=O)n(CC(OC(C)=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640153 | 252539 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 656 | 10 | 1 | 11 | 5.3 | CCc1cc2c(=O)n(CC(OC(C)=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 137662335 | 316430 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 593 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(C/C(=N\OC)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL4114708 | 316430 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 593 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(C/C(=N\OC)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 44277902 | 199982 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 627 | 11 | 0 | 10 | 5.3 | CC(=O)OCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28532 | 199982 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 627 | 11 | 0 | 10 | 5.3 | CC(=O)OCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44274673 | 194157 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 451 | 7 | 2 | 7 | 4.2 | CCCCc1nc2ccc(N)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL24724 | 194157 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 451 | 7 | 2 | 7 | 4.2 | CCCCc1nc2ccc(N)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 22574723 | 39828 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 549 | 11 | 2 | 7 | 5.2 | CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CC)c1 | 10.1039/C4MD00499J | |||
| CHEMBL12233 | 39828 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 549 | 11 | 2 | 7 | 5.2 | CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CC)c1 | 10.1039/C4MD00499J | |||
| 57380647 | 142598 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945010 | 142598 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 70686410 | 157988 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 555 | 10 | 2 | 6 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058859 | 157988 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 555 | 10 | 2 | 6 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 19939409 | 216802 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 710 | 12 | 1 | 7 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL316299 | 216802 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 710 | 12 | 1 | 7 | 7.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 10372341 | 332918 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 674 | 10 | 1 | 8 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)s2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL433375 | 332918 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 674 | 10 | 1 | 8 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(Cl)s2)cc1 | 10.1021/jm00043a020 | |||
| 10077929 | 474245 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 643 | 14 | 2 | 8 | 5.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL93606 | 474245 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 643 | 14 | 2 | 8 | 5.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 | 10.1021/jm00043a020 | |||
| 10326460 | 474953 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 614 | 9 | 1 | 7 | 6.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97897 | 474953 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 614 | 9 | 1 | 7 | 6.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| 10009735 | 314084 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 676 | 3 | 1 | 7 | 6.9 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)c1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL408798 | 314084 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 676 | 3 | 1 | 7 | 6.9 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)c1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| 76311803 | 175924 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 592 | 12 | 3 | 11 | 4.6 | CCCCc1nnc(SCc2ccccc2-c2nnn[nH]2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237602 | 175924 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 592 | 12 | 3 | 11 | 4.6 | CCCCc1nnc(SCc2ccccc2-c2nnn[nH]2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 9987311 | 235650 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 706 | 12 | 1 | 9 | 6.7 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL337588 | 235650 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 706 | 12 | 1 | 9 | 6.7 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10414470 | 41006 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 524 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9984303 | 41006 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 524 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125542 | 41006 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 524 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125818 | 41006 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 524 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44320012 | 332677 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 493 | 9 | 1 | 7 | 5.4 | CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL431411 | 332677 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 493 | 9 | 1 | 7 | 5.4 | CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 136052301 | 252518 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 594 | 9 | 1 | 11 | 5.2 | CCc1cc2c(=O)n(CC(=O)c3ccccc3OC)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3)c2s1 | nan | |||
| CHEMBL3640133 | 252518 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 594 | 9 | 1 | 11 | 5.2 | CCc1cc2c(=O)n(CC(=O)c3ccccc3OC)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3)c2s1 | nan | |||
| 136052255 | 252522 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 684 | 9 | 1 | 10 | 5.6 | COc1ccccc1C(=O)Cn1c(=O)c2cc(CC(F)(F)F)sc2n(Cc2c(F)cc(-c3ccccc3-c3nc(=O)o[nH]3)cc2F)c1=O | nan | |||
| CHEMBL3640137 | 252522 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 684 | 9 | 1 | 10 | 5.6 | COc1ccccc1C(=O)Cn1c(=O)c2cc(CC(F)(F)F)sc2n(Cc2c(F)cc(-c3ccccc3-c3nc(=O)o[nH]3)cc2F)c1=O | nan | |||
| 136052247 | 252532 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 558 | 7 | 2 | 9 | 4.6 | CC(C)(C)C(O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O | nan | |||
| CHEMBL3640146 | 252532 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 558 | 7 | 2 | 9 | 4.6 | CC(C)(C)C(O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O | nan | |||
| 136052300 | 252541 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 630 | 9 | 1 | 10 | 5.0 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)c(F)c3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640155 | 252541 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 630 | 9 | 1 | 10 | 5.0 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)c(F)c3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3F)c2s1 | nan | |||
| 136052332 | 252549 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 630 | 9 | 1 | 10 | 5.0 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3c(F)cc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640162 | 252549 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 630 | 9 | 1 | 10 | 5.0 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3c(F)cc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 136052372 | 252553 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 564 | 8 | 1 | 9 | 4.7 | CCc1cc2c(=O)n(CC(=O)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640166 | 252553 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 564 | 8 | 1 | 9 | 4.7 | CCc1cc2c(=O)n(CC(=O)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052324 | 252555 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 570 | 8 | 1 | 10 | 4.8 | CCc1cc2c(=O)n(CC(=O)c3cccs3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640171 | 252555 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 570 | 8 | 1 | 10 | 4.8 | CCc1cc2c(=O)n(CC(=O)c3cccs3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 10481968 | 103930 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 525 | 11 | 2 | 8 | 5.5 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL157577 | 103930 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 525 | 11 | 2 | 8 | 5.5 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 15236320 | 337120 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 548 | 10 | 1 | 7 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| CHEMBL449095 | 337120 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 548 | 10 | 1 | 7 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| 10054324 | 198627 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 600 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL275160 | 198627 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 600 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 10099040 | 238912 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 549 | 11 | 2 | 10 | 5.0 | CCCCc1nnc(SCc2ccccc2-c2nn[nH]n2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL352236 | 238912 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 549 | 11 | 2 | 10 | 5.0 | CCCCc1nnc(SCc2ccccc2-c2nn[nH]n2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 9852384 | 200576 | 6 | None | None | None | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/acs.jmedchem.9b01780 | |||
| CHEMBL290214 | 200576 | 6 | None | None | None | Rat | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/acs.jmedchem.9b01780 | |||
| 127035265 | 273971 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 601 | 11 | 2 | 7 | 7.3 | CCCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736514 | 273971 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 601 | 11 | 2 | 7 | 7.3 | CCCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10417195 | 218660 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 685 | 13 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL321313 | 218660 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 685 | 13 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10054324 | 198627 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 600 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL275160 | 198627 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 600 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10101690 | 235744 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338137 | 235744 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 767 | 11 | 2 | 9 | 7.7 | CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 9852384 | 200576 | 6 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm9504722 | |||
| CHEMBL290214 | 200576 | 6 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 640 | 12 | 1 | 8 | 7.1 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm9504722 | |||
| 9987311 | 235650 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 706 | 12 | 1 | 9 | 6.7 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL337588 | 235650 | 0 | None | None | None | Rabbit | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 706 | 12 | 1 | 9 | 6.7 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 19010048 | 175922 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 568 | 12 | 3 | 9 | 5.1 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237600 | 175922 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 568 | 12 | 3 | 9 | 5.1 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10327728 | 198415 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL273542 | 198415 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10369867 | 40266 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 534 | 12 | 1 | 6 | 5.9 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(C)cs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122966 | 40266 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 534 | 12 | 1 | 6 | 5.9 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(C)cs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 135876074 | 252512 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3F)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640127 | 252512 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3F)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052291 | 252528 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 642 | 9 | 1 | 10 | 5.3 | COc1ccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3c(F)cc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2=O)cc1 | nan | |||
| CHEMBL3640142 | 252528 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 642 | 9 | 1 | 10 | 5.3 | COc1ccc(C(=O)Cn2c(=O)c3cc(C4CC4)sc3n(Cc3c(F)cc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2=O)cc1 | nan | |||
| 136052286 | 252529 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 624 | 8 | 1 | 9 | 5.5 | O=C(Cn1c(=O)c2cc(CC(F)(F)F)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)C1CCCCC1 | nan | |||
| CHEMBL3640143 | 252529 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 624 | 8 | 1 | 9 | 5.5 | O=C(Cn1c(=O)c2cc(CC(F)(F)F)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)C1CCCCC1 | nan | |||
| 136052352 | 252531 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 573 | 8 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(C/C(=N/OC)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640145 | 252531 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 573 | 8 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(C/C(=N/OC)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052270 | 252535 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 602 | 10 | 1 | 11 | 4.0 | CCc1cc2c(=O)n(CC(=O)C(C)(C)COC(C)=O)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640149 | 252535 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 602 | 10 | 1 | 11 | 4.0 | CCc1cc2c(=O)n(CC(=O)C(C)(C)COC(C)=O)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052397 | 252537 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 604 | 8 | 1 | 10 | 5.4 | CCc1cc2c(=O)n(CC(=O)c3ccc(Cl)s3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640151 | 252537 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 604 | 8 | 1 | 10 | 5.4 | CCc1cc2c(=O)n(CC(=O)c3ccc(Cl)s3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052320 | 252538 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 614 | 9 | 2 | 10 | 4.7 | CCc1cc2c(=O)n(CC(O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640152 | 252538 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 614 | 9 | 2 | 10 | 4.7 | CCc1cc2c(=O)n(CC(O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 136052319 | 252550 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccc(F)cc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640163 | 252550 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccc(F)cc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052299 | 252552 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 570 | 8 | 1 | 9 | 5.0 | CCc1cc2c(=O)n(CC(=O)C3CCCCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640165 | 252552 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 570 | 8 | 1 | 9 | 5.0 | CCc1cc2c(=O)n(CC(=O)C3CCCCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 10481968 | 103930 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 525 | 11 | 2 | 8 | 5.5 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157577 | 103930 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 525 | 11 | 2 | 8 | 5.5 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 9850834 | 310695 | 23 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/ml500427r | |||
| CHEMBL39959 | 310695 | 23 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/ml500427r | |||
| 44379292 | 238999 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 613 | 12 | 1 | 6 | 7.4 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL352934 | 238999 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 613 | 12 | 1 | 6 | 7.4 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCC2CCCC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10327728 | 198415 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL273542 | 198415 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10438523 | 474989 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 598 | 10 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL98126 | 474989 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 598 | 10 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00043a020 | |||
| 11765454 | 236896 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL340473 | 236896 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 723 | 11 | 2 | 10 | 6.9 | CCCCc1nn(-c2cc(NC(=O)c3ccco3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44315144 | 196928 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL263191 | 196928 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 665 | 13 | 3 | 8 | 5.2 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 9851889 | 202170 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL302102 | 202170 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 44300838 | 410525 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 530 | 7 | 1 | 7 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL57976 | 410525 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 530 | 7 | 1 | 7 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 9850834 | 310695 | 23 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm9504722 | |||
| CHEMBL39959 | 310695 | 23 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/jm9504722 | |||
| 9851889 | 202170 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL302102 | 202170 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(96)00116-3 | |||
| 44211672 | 314085 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 706 | 4 | 1 | 8 | 7.4 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)OCc1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL408799 | 314085 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 706 | 4 | 1 | 8 | 7.4 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCCCN3C(=O)OCc1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| 10327728 | 198415 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL273542 | 198415 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 10484986 | 237494 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 713 | 11 | 1 | 9 | 6.8 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL341715 | 237494 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 713 | 11 | 1 | 9 | 6.8 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 136052375 | 252508 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 638 | 8 | 1 | 8 | 6.3 | O=c1nc(-c2ccccc2-c2ccc(Cn3c(=O)n(CCc4ccc(Cl)cc4)c(=O)c4cc(CC(F)(F)F)sc43)cc2)[nH]o1 | nan | |||
| CHEMBL3640123 | 252508 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 638 | 8 | 1 | 8 | 6.3 | O=c1nc(-c2ccccc2-c2ccc(Cn3c(=O)n(CCc4ccc(Cl)cc4)c(=O)c4cc(CC(F)(F)F)sc43)cc2)[nH]o1 | nan | |||
| 136052302 | 252523 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 642 | 9 | 1 | 10 | 5.3 | COc1cc(F)ccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2F)c1=O | nan | |||
| CHEMBL3640138 | 252523 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 642 | 9 | 1 | 10 | 5.3 | COc1cc(F)ccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2F)c1=O | nan | |||
| 136052246 | 252524 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 624 | 9 | 1 | 10 | 5.2 | COc1cc(F)ccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O | nan | |||
| CHEMBL3640139 | 252524 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 624 | 9 | 1 | 10 | 5.2 | COc1cc(F)ccc1C(=O)Cn1c(=O)c2cc(C3CC3)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O | nan | |||
| 136052258 | 252543 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 598 | 8 | 1 | 9 | 5.8 | CCc1cc2c(=O)n(-c3ccc(OC(C)C)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640157 | 252543 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 598 | 8 | 1 | 9 | 5.8 | CCc1cc2c(=O)n(-c3ccc(OC(C)C)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 136052298 | 252554 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 637 | 11 | 1 | 11 | 5.3 | CCO/N=C(/Cn1c(=O)c2cc(CC)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(OC)cc1 | nan | |||
| CHEMBL3640167 | 252554 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 637 | 11 | 1 | 11 | 5.3 | CCO/N=C(/Cn1c(=O)c2cc(CC)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(OC)cc1 | nan | |||
| 136052297 | 252557 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 578 | 8 | 1 | 8 | 5.8 | CCc1cc2c(=O)n(CC(C)(C)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640173 | 252557 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 578 | 8 | 1 | 8 | 5.8 | CCc1cc2c(=O)n(CC(C)(C)c3ccccc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(=O)[nH]4)cc3)c2s1 | nan | |||
| 44277903 | 199344 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 585 | 10 | 0 | 9 | 5.0 | CCOCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL280908 | 199344 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 585 | 10 | 0 | 9 | 5.0 | CCOCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 11764826 | 198567 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 648 | 11 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL274710 | 198567 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 648 | 11 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 15231091 | 194403 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24861 | 194403 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44274823 | 199302 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 551 | 10 | 2 | 8 | 5.8 | CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL280526 | 199302 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 551 | 10 | 2 | 8 | 5.8 | CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 45102750 | 136113 | 3 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL1801740 | 136113 | 3 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 45102750 | 136113 | 3 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801740 | 136113 | 3 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 19754050 | 468857 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 603 | 15 | 2 | 7 | 6.6 | CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL68786 | 468857 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 603 | 15 | 2 | 7 | 6.6 | CCCCC(=O)Nc1cnc2c(c1)nc(CCCC)n2Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 11764826 | 198567 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 648 | 11 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL274710 | 198567 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 648 | 11 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Cc2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10233056 | 216801 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 637 | 10 | 1 | 8 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccn2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL316297 | 216801 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 637 | 10 | 1 | 8 | 5.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccn2C)cc1 | 10.1021/jm00043a020 | |||
| 10259525 | 39510 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL122158 | 39510 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 753 | 10 | 2 | 9 | 7.3 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10259841 | 40048 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122401 | 40048 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 815 | 13 | 2 | 8 | 7.6 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(Cl)ccc4Cl)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44315351 | 214587 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311160 | 214587 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 687 | 10 | 3 | 7 | 6.2 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)NC(C)C)cc4c3=O)c(F)c2)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 10484986 | 237494 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 713 | 11 | 1 | 9 | 6.8 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL341715 | 237494 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 713 | 11 | 1 | 9 | 6.8 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 10030086 | 40405 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 535 | 12 | 1 | 7 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10392378 | 40405 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 535 | 12 | 1 | 7 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL123671 | 40405 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 535 | 12 | 1 | 7 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125383 | 40405 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 535 | 12 | 1 | 7 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 136052394 | 252521 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 598 | 8 | 1 | 9 | 5.4 | CCc1cc2c(=O)n(CC(=O)c3ccc(Cl)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640136 | 252521 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 598 | 8 | 1 | 9 | 5.4 | CCc1cc2c(=O)n(CC(=O)c3ccc(Cl)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052399 | 252527 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 622 | 8 | 1 | 9 | 5.6 | CCc1cc2c(=O)n(CC(=O)C34CC5CC(CC(C5)C3)C4)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640141 | 252527 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 622 | 8 | 1 | 9 | 5.6 | CCc1cc2c(=O)n(CC(=O)C34CC5CC(CC(C5)C3)C4)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052347 | 252530 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 618 | 8 | 1 | 11 | 4.6 | CCc1cc2c(=O)n(CC(=O)c3nc4ccccc4n3C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640144 | 252530 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 618 | 8 | 1 | 11 | 4.6 | CCc1cc2c(=O)n(CC(=O)c3nc4ccccc4n3C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052345 | 252533 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 530 | 7 | 1 | 9 | 3.9 | CCc1cc2c(=O)n(CC3(C)COC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640147 | 252533 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 530 | 7 | 1 | 9 | 3.9 | CCc1cc2c(=O)n(CC3(C)COC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052268 | 252534 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 560 | 7 | 2 | 10 | 3.4 | CCc1cc2c(=O)n(CC3(O)CCOCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640148 | 252534 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 560 | 7 | 2 | 10 | 3.4 | CCc1cc2c(=O)n(CC3(O)CCOCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052310 | 252542 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 626 | 10 | 1 | 10 | 5.3 | CCCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640156 | 252542 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 626 | 10 | 1 | 10 | 5.3 | CCCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 136052379 | 252548 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 672 | 9 | 1 | 11 | 5.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3Br)c2s1 | nan | |||
| CHEMBL3640161 | 252548 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 672 | 9 | 1 | 11 | 5.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3Br)c2s1 | nan | |||
| 9851889 | 202170 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| CHEMBL302102 | 202170 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| 44277573 | 199740 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4cccnc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL283495 | 199740 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4cccnc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44277442 | 200465 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28917 | 200465 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44277451 | 201048 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 601 | 10 | 0 | 8 | 6.3 | CCCCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29386 | 201048 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 601 | 10 | 0 | 8 | 6.3 | CCCCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44283174 | 200250 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 617 | 9 | 1 | 7 | 7.2 | CCCc1nc2ccc(N(C(=O)c3ccccc3)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL287250 | 200250 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 617 | 9 | 1 | 7 | 7.2 | CCCc1nc2ccc(N(C(=O)c3ccccc3)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 9851889 | 202170 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL302102 | 202170 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(01)80595-3 | |||
| 44310589 | 332827 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 488 | 6 | 1 | 5 | 5.4 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| CHEMBL432734 | 332827 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 488 | 6 | 1 | 5 | 5.4 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| 9851889 | 202170 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00019a004 | |||
| CHEMBL302102 | 202170 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00019a004 | |||
| 44377199 | 120215 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 531 | 10 | 2 | 6 | 4.9 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL165349 | 120215 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 531 | 10 | 2 | 6 | 4.9 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 9851889 | 202170 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm9504722 | |||
| CHEMBL302102 | 202170 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm9504722 | |||
| 9801006 | 238448 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 398 | 6 | 1 | 7 | 3.6 | CCc1nc2c(CC)cn(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)n2n1 | 10.1021/jm9504722 | |||
| CHEMBL347610 | 238448 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 398 | 6 | 1 | 7 | 3.6 | CCc1nc2c(CC)cn(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)n2n1 | 10.1021/jm9504722 | |||
| 9851889 | 202170 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm058225d | |||
| CHEMBL302102 | 202170 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm058225d | |||
| 9851889 | 202170 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00052a006 | |||
| CHEMBL302102 | 202170 | 0 | None | None | None | Rabbit | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00052a006 | |||
| 10258916 | 63365 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 668 | 11 | 1 | 10 | 6.1 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL138654 | 63365 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 668 | 11 | 1 | 10 | 6.1 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1007/s00044-013-0831-x | |||
| 10010164 | 236244 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL339806 | 236244 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 9845644 | 473400 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 431 | 9 | 1 | 7 | 4.3 | CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87964 | 473400 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 431 | 9 | 1 | 7 | 4.3 | CCCCc1nn(C(C)CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 136052351 | 252519 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 608 | 9 | 1 | 11 | 5.5 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3C)c2s1 | nan | |||
| CHEMBL3640134 | 252519 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 608 | 9 | 1 | 11 | 5.5 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4noc(O)n4)cc3C)c2s1 | nan | |||
| 136052241 | 252520 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 577 | 8 | 1 | 10 | 3.3 | CCc1cc2c(=O)n(CCN3CCOCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| CHEMBL3640135 | 252520 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 577 | 8 | 1 | 10 | 3.3 | CCc1cc2c(=O)n(CCN3CCOCC3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3F)c2s1 | nan | |||
| 136052269 | 252536 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 546 | 7 | 2 | 9 | 4.3 | CCc1cc2c(=O)n(CC(O)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640150 | 252536 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 546 | 7 | 2 | 9 | 4.3 | CCc1cc2c(=O)n(CC(O)C(C)(C)C)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136052400 | 252551 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4cc(F)ccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640164 | 252551 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 612 | 9 | 1 | 10 | 4.9 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4cc(F)ccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 136401533 | 316436 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 649 | 12 | 1 | 11 | 5.5 | C=CCO/N=C(\Cn1c(=O)c2cc(CC)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(OC)cc1 | nan | |||
| CHEMBL4114807 | 316436 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 649 | 12 | 1 | 11 | 5.5 | C=CCO/N=C(\Cn1c(=O)c2cc(CC)sc2n(Cc2ccc(-c3ccccc3-c3nc(=O)o[nH]3)cc2)c1=O)c1ccc(OC)cc1 | nan | |||
| 10010164 | 236244 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL339806 | 236244 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10100074 | 222040 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 598 | 9 | 1 | 6 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL330007 | 222040 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 598 | 9 | 1 | 6 | 6.4 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)C(F)(F)F)cc1 | 10.1021/jm00043a020 | |||
| 9810305 | 198833 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| CHEMBL276674 | 198833 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 701 | 11 | 2 | 9 | 6.7 | CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00019a004 | |||
| 10258916 | 63365 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 668 | 11 | 1 | 10 | 6.1 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL138654 | 63365 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 668 | 11 | 1 | 10 | 6.1 | CCCCc1nn(-c2ccc(C(=O)OCC)cc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1021/jm00052a006 | |||
| 10010164 | 236244 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL339806 | 236244 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 10394859 | 41301 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL125760 | 41301 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 9960721 | 40200 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 549 | 12 | 0 | 8 | 5.4 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122638 | 40200 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 549 | 12 | 0 | 8 | 5.4 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 59351471 | 252540 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 417 | 5 | 1 | 6 | 3.9 | CCc1cc2c(=O)[nH]c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3OC)c2s1 | nan | |||
| CHEMBL3640154 | 252540 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 417 | 5 | 1 | 6 | 3.9 | CCc1cc2c(=O)[nH]c(=O)n(Cc3ccc(-c4ccccc4C#N)cc3OC)c2s1 | nan | |||
| 136052367 | 252556 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 648 | 8 | 1 | 10 | 5.6 | CCc1cc2c(=O)n(CC(=O)c3sccc3Br)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL3640172 | 252556 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 648 | 8 | 1 | 10 | 5.6 | CCc1cc2c(=O)n(CC(=O)c3sccc3Br)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 44277652 | 200012 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 573 | 8 | 0 | 8 | 5.5 | CCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28555 | 200012 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 573 | 8 | 0 | 8 | 5.5 | CCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 10394859 | 41301 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL125760 | 41301 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44376746 | 238570 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 568 | 16 | 2 | 7 | 5.9 | CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)OC)cnc2CCCC)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL348758 | 238570 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 568 | 16 | 2 | 7 | 5.9 | CCCCCCCC(=O)NS(=O)(=O)Nc1ccccc1-c1ccc(Cn2c(C(=O)OC)cnc2CCCC)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10033136 | 39963 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122380 | 39963 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 769 | 12 | 2 | 8 | 6.7 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4cc(F)ccc4F)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44315078 | 469641 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74556 | 469641 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 693 | 13 | 2 | 8 | 6.9 | CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44303230 | 448632 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL59957 | 448632 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9504722 | |||
| 10394859 | 41301 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| CHEMBL125760 | 41301 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1007/s00044-011-9815-x | |||
| 76308179 | 175929 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 584 | 12 | 3 | 9 | 4.1 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237607 | 175929 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 584 | 12 | 3 | 9 | 4.1 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10222835 | 470930 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 403 | 8 | 1 | 7 | 3.3 | CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL86084 | 470930 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 403 | 8 | 1 | 7 | 3.3 | CCCCc1nn(CC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44459556 | 198979 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 436 | 6 | 1 | 6 | 4.6 | CCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL277902 | 198979 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 436 | 6 | 1 | 6 | 4.6 | CCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 19087866 | 199171 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 436 | 7 | 1 | 6 | 4.6 | CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL279515 | 199171 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 436 | 7 | 1 | 6 | 4.6 | CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 44459544 | 199576 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 454 | 7 | 1 | 6 | 4.8 | CCCCc1nc2cccc(F)c2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL282526 | 199576 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 454 | 7 | 1 | 6 | 4.8 | CCCCc1nc2cccc(F)c2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 44311428 | 203019 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 647 | 17 | 1 | 8 | 7.1 | CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306473 | 203019 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 647 | 17 | 1 | 8 | 7.1 | CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311543 | 213860 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 643 | 14 | 1 | 8 | 6.3 | CCCCN(Cc1ccccc1)C(=O)C#CCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL309455 | 213860 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 643 | 14 | 1 | 8 | 6.3 | CCCCN(Cc1ccccc1)C(=O)C#CCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 10325037 | 238503 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 541 | 11 | 2 | 8 | 4.5 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL348143 | 238503 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 541 | 11 | 2 | 8 | 4.5 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 73353933 | 183428 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 554 | 11 | 2 | 6 | 5.2 | CCCc1nc2c(C)cc(C(=O)NCCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435821 | 183428 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 554 | 11 | 2 | 6 | 5.2 | CCCc1nc2c(C)cc(C(=O)NCCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 70696780 | 157878 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 592 | 9 | 1 | 6 | 7.3 | CCCCc1nc2ccc(Br)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058374 | 157878 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 592 | 9 | 1 | 6 | 7.3 | CCCCc1nc2ccc(Br)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 19102815 | 474743 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 672 | 11 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL96554 | 474743 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 672 | 11 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 44311342 | 202272 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 611 | 12 | 3 | 7 | 5.9 | CCCc1nc(CNC(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL302760 | 202272 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 611 | 12 | 3 | 7 | 5.9 | CCCc1nc(CNC(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311450 | 213820 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 652 | 12 | 2 | 8 | 6.4 | CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL309365 | 213820 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 652 | 12 | 2 | 8 | 6.4 | CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311688 | 213915 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 554 | 10 | 2 | 8 | 3.5 | CCCc1nc(CN2CCN(C(=O)C3CC3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL309820 | 213915 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 554 | 10 | 2 | 8 | 3.5 | CCCc1nc(CN2CCN(C(=O)C3CC3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 15222101 | 314432 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 642 | 12 | 2 | 9 | 4.2 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL409170 | 314432 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 642 | 12 | 2 | 9 | 4.2 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311664 | 469098 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 680 | 12 | 2 | 8 | 5.9 | CCCc1nc(CN2CCN(C(=O)C(c3ccccc3)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL70638 | 469098 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 680 | 12 | 2 | 8 | 5.9 | CCCc1nc(CN2CCN(C(=O)C(c3ccccc3)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311449 | 469382 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 549 | 10 | 2 | 9 | 3.9 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL72409 | 469382 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 549 | 10 | 2 | 9 | 3.9 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 15292111 | 469630 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74442 | 469630 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 665 | 11 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10100413 | 409374 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 620 | 9 | 1 | 7 | 7.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(Cc3ccccc3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL57853 | 409374 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 620 | 9 | 1 | 7 | 7.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(Cc3ccccc3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 44300798 | 425059 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 558 | 8 | 1 | 7 | 6.1 | CCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL58499 | 425059 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 558 | 8 | 1 | 7 | 6.1 | CCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| 15287894 | 117790 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 449 | 7 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL16148 | 117790 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 449 | 7 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 10324361 | 40807 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 519 | 12 | 0 | 8 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccno2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125273 | 40807 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 519 | 12 | 0 | 8 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccno2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 172198 | 866 | 40 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1016/j.bmcl.2021.128086 | |||
| 2504 | 866 | 40 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1016/j.bmcl.2021.128086 | |||
| 5272 | 866 | 40 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1016/j.bmcl.2021.128086 | |||
| CHEMBL408403 | 866 | 40 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1016/j.bmcl.2021.128086 | |||
| DB11842 | 866 | 40 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1016/j.bmcl.2021.128086 | |||
| P01015 | 866 | 40 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1016/j.bmcl.2021.128086 | |||
| P01019 | 866 | 40 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1016/j.bmcl.2021.128086 | |||
| P11859 | 866 | 40 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1016/j.bmcl.2021.128086 | |||
| 53309130 | 136107 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 449 | 4 | 1 | 6 | 5.6 | Cc1cc(C)c2nc(C(C)C)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| CHEMBL1801734 | 136107 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 449 | 4 | 1 | 6 | 5.6 | Cc1cc(C)c2nc(C(C)C)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| 70690542 | 157879 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 532 | 9 | 1 | 6 | 6.6 | CCCCc1nc2ccc(F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058375 | 157879 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 532 | 9 | 1 | 6 | 6.6 | CCCCc1nc2ccc(F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 53309128 | 136117 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 453 | 6 | 1 | 4 | 6.4 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3C(=O)O)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801744 | 136117 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 453 | 6 | 1 | 4 | 6.4 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3C(=O)O)ccc21 | 10.1021/jm200409s | |||
| 44277549 | 199352 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 594 | 8 | 0 | 10 | 5.1 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccco4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL280988 | 199352 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 594 | 8 | 0 | 10 | 5.1 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccco4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 2541 | 7891 | 68 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 6907 | 7891 | 68 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL1016 | 7891 | 68 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 76315368 | 175909 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 510 | 10 | 2 | 8 | 5.3 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237587 | 175909 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 510 | 10 | 2 | 8 | 5.3 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956760 | 330377 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 466 | 8 | 2 | 8 | 3.9 | CCCCc1nn(-c2ccccc2N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL424053 | 330377 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 466 | 8 | 2 | 8 | 3.9 | CCCCc1nn(-c2ccccc2N)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44348352 | 40415 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 459 | 8 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC | 10.1016/S0960-894X(01)80914-8 | |||
| CHEMBL123713 | 40415 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 459 | 8 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(CC)CC | 10.1016/S0960-894X(01)80914-8 | |||
| 44285157 | 310736 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 484 | 6 | 1 | 5 | 5.2 | CC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL39978 | 310736 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 484 | 6 | 1 | 5 | 5.2 | CC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 10412300 | 101407 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 467 | 9 | 1 | 7 | 5.7 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155154 | 101407 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 467 | 9 | 1 | 7 | 5.7 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44311472 | 213514 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 669 | 14 | 3 | 8 | 5.7 | CCCc1nc(CN(CC(=O)O)C(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL308943 | 213514 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 669 | 14 | 3 | 8 | 5.7 | CCCc1nc(CN(CC(=O)O)C(=O)C(c2ccccc2)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 10500716 | 24526 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 392 | 8 | 2 | 4 | 4.5 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL116054 | 24526 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 392 | 8 | 2 | 4 | 4.5 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 9867446 | 333910 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 432 | 8 | 3 | 7 | 3.1 | CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL441649 | 333910 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 432 | 8 | 3 | 7 | 3.1 | CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 44305424 | 202561 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 388 | 6 | 2 | 6 | 2.4 | CCCc1cc(=O)[nH]c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL304032 | 202561 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 388 | 6 | 2 | 6 | 2.4 | CCCc1cc(=O)[nH]c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 10434949 | 238374 | 0 | None | None | None | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.0 | CCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL346745 | 238374 | 0 | None | None | None | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.0 | CCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10456123 | 330205 | 0 | None | None | None | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 444 | 9 | 2 | 6 | 4.9 | CCCCc1nnc(-c2ccco2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL423418 | 330205 | 0 | None | None | None | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 444 | 9 | 2 | 6 | 4.9 | CCCCc1nnc(-c2ccco2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 76310609 | 214944 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCn1nc2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115244 | 214944 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCn1nc2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| 44298831 | 389527 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 496 | 8 | 2 | 8 | 4.2 | CC(C)COc1nc2ccc(C(C)O)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL54699 | 389527 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 496 | 8 | 2 | 8 | 4.2 | CC(C)COc1nc2ccc(C(C)O)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 10434949 | 238374 | 0 | None | None | None | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.0 | CCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL346745 | 238374 | 0 | None | None | None | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.0 | CCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10456123 | 330205 | 0 | None | None | None | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 444 | 9 | 2 | 6 | 4.9 | CCCCc1nnc(-c2ccco2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL423418 | 330205 | 0 | None | None | None | Rabbit | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 444 | 9 | 2 | 6 | 4.9 | CCCCc1nnc(-c2ccco2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 15654731 | 202283 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 482 | 9 | 1 | 8 | 4.9 | CCCOc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL302815 | 202283 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 482 | 9 | 1 | 8 | 4.9 | CCCOc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 44305441 | 201085 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 388 | 5 | 1 | 7 | 2.0 | CCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL294075 | 201085 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 388 | 5 | 1 | 7 | 2.0 | CCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 44303886 | 201023 | 0 | None | None | None | Rabbit | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 522 | 11 | 1 | 3 | 6.1 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(C)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL293660 | 201023 | 0 | None | None | None | Rabbit | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 522 | 11 | 1 | 3 | 6.1 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(C)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 44303852 | 202431 | 0 | None | None | None | Rabbit | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 524 | 11 | 2 | 4 | 5.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(O)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL303755 | 202431 | 0 | None | None | None | Rabbit | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 524 | 11 | 2 | 4 | 5.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(O)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 73346387 | 183439 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 497 | 7 | 1 | 5 | 5.2 | CCCc1nc2c(C)cc(C(=O)N3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435832 | 183439 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 497 | 7 | 1 | 5 | 5.2 | CCCc1nc2c(C)cc(C(=O)N3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 9850385 | 201807 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 544 | 8 | 1 | 8 | 5.2 | CCCCc1nc2ccc(C3=NN4CCCC4C3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL299391 | 201807 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 544 | 8 | 1 | 8 | 5.2 | CCCCc1nc2ccc(C3=NN4CCCC4C3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 11757908 | 236181 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 578 | 12 | 0 | 6 | 6.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc3ccccc3c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL339709 | 236181 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 578 | 12 | 0 | 6 | 6.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc3ccccc3c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 127034874 | 273849 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735333 | 273849 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44212049 | 201587 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 560 | 8 | 1 | 7 | 6.7 | CCCCc1nc2ccc(C3CCC4CCCC4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL297714 | 201587 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 560 | 8 | 1 | 7 | 6.7 | CCCCc1nc2ccc(C3CCC4CCCC4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 44297113 | 201693 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 637 | 9 | 1 | 9 | 6.8 | CCCCc1nc2ccc([C@@H]3C[C@H]4C(c5ccc(C)cc5)=NO[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL298560 | 201693 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 637 | 9 | 1 | 9 | 6.8 | CCCCc1nc2ccc([C@@H]3C[C@H]4C(c5ccc(C)cc5)=NO[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 57380648 | 142618 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 549 | 10 | 2 | 4 | 6.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945148 | 142618 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 549 | 10 | 2 | 4 | 6.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 127034876 | 273868 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735487 | 273868 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 24827768 | 314948 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 411 | 6 | 1 | 7 | 3.5 | CCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL409744 | 314948 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 411 | 6 | 1 | 7 | 3.5 | CCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 10483230 | 100099 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 574 | 11 | 2 | 8 | 5.1 | CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL154027 | 100099 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 574 | 11 | 2 | 8 | 5.1 | CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 19939367 | 215635 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL312921 | 215635 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 14956792 | 216427 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL314447 | 216427 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 14956754 | 313285 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 541 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL407827 | 313285 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 541 | 10 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44277440 | 199197 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4cccnc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL279756 | 199197 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4cccnc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44307171 | 201064 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 481 | 5 | 2 | 5 | 4.7 | CCCc1nc2c(C)cc(C(=O)O)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL293926 | 201064 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 481 | 5 | 2 | 5 | 4.7 | CCCc1nc2c(C)cc(C(=O)O)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44373246 | 332975 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 435 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL433895 | 332975 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 435 | 5 | 1 | 6 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)C(Cc1nnn[nH]1)c1ccccc1-2 | 10.1016/j.bmc.2010.10.043 | |||
| 9824568 | 469319 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 441 | 5 | 2 | 7 | 2.8 | Cc1nc(C(=O)O)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm0204237 | |||
| CHEMBL72053 | 469319 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 441 | 5 | 2 | 7 | 2.8 | Cc1nc(C(=O)O)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm0204237 | |||
| 10052777 | 101768 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 531 | 10 | 1 | 7 | 5.5 | CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155638 | 101768 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 531 | 10 | 1 | 7 | 5.5 | CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 73355474 | 183426 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 540 | 10 | 2 | 6 | 4.8 | CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435819 | 183426 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 540 | 10 | 2 | 6 | 4.8 | CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 70696781 | 157880 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 582 | 9 | 1 | 6 | 7.5 | CCCCc1nc2ccc(C(F)(F)F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058376 | 157880 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 582 | 9 | 1 | 6 | 7.5 | CCCCc1nc2ccc(C(F)(F)F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 15236329 | 333926 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 598 | 6 | 1 | 7 | 6.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NN(c3ccccc3Br)[S+]([O-])N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL441837 | 333926 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 598 | 6 | 1 | 7 | 6.4 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NN(c3ccccc3Br)[S+]([O-])N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 10501285 | 328411 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 402 | 7 | 2 | 6 | 3.7 | CCCc1nc(C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL419762 | 328411 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 402 | 7 | 2 | 6 | 3.7 | CCCc1nc(C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 44384871 | 257250 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 726 | 14 | 1 | 7 | 8.0 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3)c(=O)c2c1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL367095 | 257250 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 726 | 14 | 1 | 7 | 8.0 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4)cc3)c(=O)c2c1 | 10.1016/0960-894X(96)00116-3 | |||
| 10095637 | 103206 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 457 | 9 | 1 | 5 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15689 | 103206 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 457 | 9 | 1 | 5 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| 19385665 | 104296 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 471 | 9 | 1 | 5 | 6.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1C | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15788 | 104296 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 471 | 9 | 1 | 5 | 6.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1C | 10.1016/0960-894X(95)00185-V | |||
| 10053367 | 236097 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 553 | 12 | 0 | 7 | 5.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C#N)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL339480 | 236097 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 553 | 12 | 0 | 7 | 5.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C#N)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10029695 | 314395 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 521 | 10 | 0 | 8 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL409136 | 314395 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 521 | 10 | 0 | 8 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9983135 | 333272 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 492 | 11 | 0 | 6 | 5.4 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2C=C(C)C)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL435994 | 333272 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 492 | 11 | 0 | 6 | 5.4 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2C=C(C)C)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 168475982 | 386192 | 3 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 315 | 3 | 1 | 4 | 2.8 | CS(=O)(=O)n1c(-c2ccccc2)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5271484 | 386192 | 3 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 315 | 3 | 1 | 4 | 2.8 | CS(=O)(=O)n1c(-c2ccccc2)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| 44309702 | 468730 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 591 | 13 | 2 | 8 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3cc(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL67805 | 468730 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 591 | 13 | 2 | 8 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3cc(NC(=O)CCCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 76322689 | 175913 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 558 | 11 | 2 | 8 | 6.0 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237591 | 175913 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 558 | 11 | 2 | 8 | 6.0 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956796 | 470608 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2cccc(C(=O)OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL83182 | 470608 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2cccc(C(=O)OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 2541 | 7891 | 68 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2010.10.043 | |||
| 6907 | 7891 | 68 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1016 | 7891 | 68 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.bmc.2010.10.043 | |||
| 2541 | 7891 | 68 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/S0960-894X(01)81118-5 | |||
| 6907 | 7891 | 68 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL1016 | 7891 | 68 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/S0960-894X(01)81118-5 | |||
| 2541 | 7891 | 68 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| 6907 | 7891 | 68 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL1016 | 7891 | 68 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| 10006742 | 101182 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 515 | 10 | 1 | 7 | 6.5 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154949 | 101182 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 515 | 10 | 1 | 7 | 6.5 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44297172 | 317714 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 587 | 8 | 2 | 10 | 2.9 | CCCCc1nc2ccc(C3=NN[C@H]4C(=O)N(C)C(=O)[C@@H]34)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL416296 | 317714 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 587 | 8 | 2 | 10 | 2.9 | CCCCc1nc2ccc(C3=NN[C@H]4C(=O)N(C)C(=O)[C@@H]34)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 10671263 | 24278 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 450 | 10 | 3 | 5 | 5.0 | CCCc1nc(C(O)(CC)CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL114788 | 24278 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 450 | 10 | 3 | 5 | 5.0 | CCCc1nc(C(O)(CC)CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10571686 | 24382 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 378 | 7 | 2 | 4 | 4.3 | CCCc1nc(C)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL115392 | 24382 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 378 | 7 | 2 | 4 | 4.3 | CCCc1nc(C)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 19939495 | 474694 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL96314 | 474694 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 2541 | 7891 | 68 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm00067a016 | |||
| 6907 | 7891 | 68 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm00067a016 | |||
| CHEMBL1016 | 7891 | 68 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm00067a016 | |||
| 4110026 | 469805 | 1 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 384 | 7 | 1 | 3 | 5.8 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL7632 | 469805 | 1 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 384 | 7 | 1 | 3 | 5.8 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| 44307088 | 202292 | 0 | None | None | None | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 465 | 4 | 1 | 6 | 3.8 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c(C(=O)OC)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL302869 | 202292 | 0 | None | None | None | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 465 | 4 | 1 | 6 | 3.8 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c(C(=O)OC)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44295557 | 201886 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299980 | 201886 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792135 | 372628 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 424 | 7 | 2 | 6 | 5.0 | CCCCc1nc2cccc(O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51399 | 372628 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 424 | 7 | 2 | 6 | 5.0 | CCCCc1nc2cccc(O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 15355267 | 385732 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 486 | 8 | 2 | 6 | 5.6 | CCCCc1nc2cc(Cl)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52343 | 385732 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 486 | 8 | 2 | 6 | 5.6 | CCCCc1nc2cc(Cl)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 4110026 | 469805 | 1 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 384 | 7 | 1 | 3 | 5.8 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL7632 | 469805 | 1 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 384 | 7 | 1 | 3 | 5.8 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| 53837978 | 5951 | 52 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| 8374 | 5951 | 52 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| 9892451 | 5951 | 52 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| 9937291 | 5951 | 52 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| CHEMBL155836 | 5951 | 52 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| CHEMBL34124 | 5951 | 52 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| CHEMBL4448705 | 5951 | 52 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| DB16266 | 5951 | 52 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| 44306628 | 468492 | 0 | None | None | None | Rabbit | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 421 | 3 | 0 | 3 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)cc(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL66056 | 468492 | 0 | None | None | None | Rabbit | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 421 | 3 | 0 | 3 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)cc(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44295557 | 201886 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299980 | 201886 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792135 | 372628 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 424 | 7 | 2 | 6 | 5.0 | CCCCc1nc2cccc(O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51399 | 372628 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 424 | 7 | 2 | 6 | 5.0 | CCCCc1nc2cccc(O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 15355267 | 385732 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 486 | 8 | 2 | 6 | 5.6 | CCCCc1nc2cc(Cl)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52343 | 385732 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 486 | 8 | 2 | 6 | 5.6 | CCCCc1nc2cc(Cl)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 127034905 | 273806 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 561 | 10 | 2 | 4 | 7.8 | CCCc1nc2c(C)cc(C(=S)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734859 | 273806 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 561 | 10 | 2 | 4 | 7.8 | CCCc1nc2c(C)cc(C(=S)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 24828714 | 196516 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 453 | 8 | 1 | 8 | 4.0 | CCCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc2c1=O | 10.1021/jm7011563 | |||
| CHEMBL260578 | 196516 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 453 | 8 | 1 | 8 | 4.0 | CCCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc2c1=O | 10.1021/jm7011563 | |||
| 178295433 | 466583 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 333 | 5 | 1 | 4 | 3.2 | CCCCN1C(=O)Cc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/acs.jmedchem.4c01617 | |||
| CHEMBL6149456 | 466583 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 333 | 5 | 1 | 4 | 3.2 | CCCCN1C(=O)Cc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/acs.jmedchem.4c01617 | |||
| 14956759 | 470888 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 495 | 9 | 2 | 8 | 4.0 | CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL85704 | 470888 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 495 | 9 | 2 | 8 | 4.0 | CCCCc1nn(-c2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 73350990 | 183427 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 545 | 11 | 2 | 4 | 7.1 | CCCc1nc2c(C)cc(C(=O)NCCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435820 | 183427 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 545 | 11 | 2 | 4 | 7.1 | CCCc1nc2c(C)cc(C(=O)NCCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 178295433 | 466583 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 333 | 5 | 1 | 4 | 3.2 | CCCCN1C(=O)Cc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/acs.jmedchem.4c01617 | |||
| CHEMBL6149456 | 466583 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 333 | 5 | 1 | 4 | 3.2 | CCCCN1C(=O)Cc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/acs.jmedchem.4c01617 | |||
| 19889359 | 315935 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ncccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| CHEMBL410939 | 315935 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ncccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| 10257293 | 40801 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 562 | 12 | 0 | 6 | 6.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc(Cl)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125233 | 40801 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 562 | 12 | 0 | 6 | 6.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc(Cl)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 70690743 | 158286 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 4.4 | CCCCc1c(Br)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063981 | 158286 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 4.4 | CCCCc1c(Br)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 70690743 | 158286 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 4.4 | CCCCc1c(Br)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063981 | 158286 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 4.4 | CCCCc1c(Br)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 14950487 | 195009 | 0 | None | None | None | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 401 | 6 | 2 | 6 | 3.8 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)O)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL25220 | 195009 | 0 | None | None | None | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 401 | 6 | 2 | 6 | 3.8 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)O)c(C)n1 | 10.1021/jm00061a016 | |||
| 70688502 | 157986 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058857 | 157986 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 44459867 | 194300 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 504 | 7 | 1 | 6 | 5.7 | CCCCc1nc2ccc(C(F)(F)F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL24802 | 194300 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 504 | 7 | 1 | 6 | 5.7 | CCCCc1nc2ccc(C(F)(F)F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 44274710 | 200116 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 562 | 7 | 1 | 6 | 5.2 | CCCCc1nc2ccc(I)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL286260 | 200116 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 562 | 7 | 1 | 6 | 5.2 | CCCCc1nc2ccc(I)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 14956793 | 473284 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87129 | 473284 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.6 | CCCCc1nn(Cc2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 14956798 | 473376 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.0 | CCCCc1nn(C(C(=O)OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87798 | 473376 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.0 | CCCCc1nn(C(C(=O)OC)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 9954408 | 474825 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 430 | 10 | 1 | 6 | 4.7 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL9714 | 474825 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 430 | 10 | 1 | 6 | 4.7 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 70684240 | 157881 | 0 | None | None | None | Bovine | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 559 | 10 | 1 | 8 | 6.4 | CCCCc1nc2ccc([N+](=O)[O-])cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058377 | 157881 | 0 | None | None | None | Bovine | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 559 | 10 | 1 | 8 | 6.4 | CCCCc1nc2ccc([N+](=O)[O-])cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 44274710 | 200116 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 562 | 7 | 1 | 6 | 5.2 | CCCCc1nc2ccc(I)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL286260 | 200116 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 562 | 7 | 1 | 6 | 5.2 | CCCCc1nc2ccc(I)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44379347 | 239132 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 544 | 9 | 1 | 7 | 4.3 | CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL354338 | 239132 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 544 | 9 | 1 | 7 | 4.3 | CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44379291 | 239158 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 702 | 15 | 2 | 8 | 7.5 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCNC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL354535 | 239158 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 702 | 15 | 2 | 8 | 7.5 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCNC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 3081289 | 24326 | 7 | None | None | None | Bovine | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL115021 | 24326 | 7 | None | None | None | Bovine | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 44377075 | 238673 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 479 | 10 | 1 | 6 | 4.1 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL349869 | 238673 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 479 | 10 | 1 | 6 | 4.1 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 44315180 | 202949 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL305956 | 202949 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 15292112 | 202998 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL306361 | 202998 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 635 | 11 | 3 | 8 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OCCC4CC4)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 44270330 | 104978 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 471 | 10 | 1 | 5 | 6.2 | CCCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15847 | 104978 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 471 | 10 | 1 | 5 | 6.2 | CCCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| 44270278 | 199103 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 443 | 8 | 1 | 5 | 5.4 | CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL278983 | 199103 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 443 | 8 | 1 | 5 | 5.4 | CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| 168475981 | 386245 | 3 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 4.7 | O=C(O)c1c(-c2ccccc2)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5272962 | 386245 | 3 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 4.7 | O=C(O)c1c(-c2ccccc2)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| 10324657 | 232752 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 528 | 12 | 0 | 6 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL332323 | 232752 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 528 | 12 | 0 | 6 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 46184983 | 177696 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 513 | 6 | 1 | 7 | 5.2 | CCc1nc2ccn(Cc3ccccc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322437 | 177696 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 513 | 6 | 1 | 7 | 5.2 | CCc1nc2ccn(Cc3ccccc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 44295057 | 201464 | 0 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 473 | 7 | 1 | 6 | 4.8 | CCOC(=O)/C=C1\CC(C)(C(C)C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL296731 | 201464 | 0 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 473 | 7 | 1 | 6 | 4.8 | CCOC(=O)/C=C1\CC(C)(C(C)C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44295068 | 372179 | 0 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL50906 | 372179 | 0 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44274691 | 195931 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 583 | 9 | 2 | 8 | 4.9 | CCCCc1nc2ccc(NS(=O)(=O)C(F)(F)F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25767 | 195931 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 583 | 9 | 2 | 8 | 4.9 | CCCCc1nc2ccc(NS(=O)(=O)C(F)(F)F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 19010044 | 175919 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 582 | 12 | 2 | 10 | 5.2 | CCCCc1nnc(SCc2ccc(C(=O)OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237597 | 175919 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 582 | 12 | 2 | 10 | 5.2 | CCCCc1nnc(SCc2ccc(C(=O)OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956742 | 473302 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2cccc(Cl)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87275 | 473302 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2cccc(Cl)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 9984755 | 101212 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 539 | 11 | 1 | 9 | 5.6 | CCCCc1nnc(SCc2ccc(C(=O)OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154975 | 101212 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 539 | 11 | 1 | 9 | 5.6 | CCCCc1nnc(SCc2ccc(C(=O)OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10074143 | 102242 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.5 | CCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156070 | 102242 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.5 | CCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 1610 | 7967 | 67 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | |||
| 3941 | 7967 | 67 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | |||
| 3961 | 7967 | 67 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2007.02.042 | |||
| 44358304 | 235679 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 521 | 5 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NS(=O)(=O)c3ccccc3N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL337787 | 235679 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 521 | 5 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NS(=O)(=O)c3ccccc3N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 1610 | 7967 | 67 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm950450f | |||
| 3941 | 7967 | 67 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm950450f | |||
| 3961 | 7967 | 67 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm950450f | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm950450f | |||
| 11754802 | 235433 | 0 | None | None | None | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 441 | 6 | 1 | 5 | 5.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(Cl)cccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL336167 | 235433 | 0 | None | None | None | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 441 | 6 | 1 | 5 | 5.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(Cl)cccc2n1 | 10.1021/jm00100a007 | |||
| 14950499 | 199717 | 0 | None | None | None | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 387 | 6 | 2 | 6 | 3.6 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL283372 | 199717 | 0 | None | None | None | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 387 | 6 | 2 | 6 | 3.6 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)c(C)n1 | 10.1021/jm00061a016 | |||
| 1610 | 7967 | 67 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| 3941 | 7967 | 67 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| 3961 | 7967 | 67 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| 15654764 | 202765 | 0 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 470 | 8 | 2 | 7 | 5.1 | CCCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL304772 | 202765 | 0 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 470 | 8 | 2 | 7 | 5.1 | CCCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 10181864 | 469217 | 0 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 442 | 6 | 2 | 7 | 4.4 | CSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL71384 | 469217 | 0 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 442 | 6 | 2 | 7 | 4.4 | CSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 19385644 | 198998 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 519 | 9 | 1 | 6 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(=O)c2ccccc2)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL278061 | 198998 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 519 | 9 | 1 | 6 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(=O)c2ccccc2)c1 | 10.1016/0960-894X(95)00185-V | |||
| 10481742 | 238764 | 0 | None | None | None | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 518 | 11 | 2 | 7 | 6.1 | CCCSc1nnc(CSc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL350697 | 238764 | 0 | None | None | None | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 518 | 11 | 2 | 7 | 6.1 | CCCSc1nnc(CSc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44352156 | 333294 | 0 | None | None | None | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 432 | 6 | 1 | 7 | 5.4 | CCSc1nc2c(C)scc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL436192 | 333294 | 0 | None | None | None | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 432 | 6 | 1 | 7 | 5.4 | CCSc1nc2c(C)scc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| 15780090 | 200610 | 0 | None | None | None | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 631 | 9 | 1 | 7 | 7.3 | CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL290669 | 200610 | 0 | None | None | None | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 631 | 9 | 1 | 7 | 7.3 | CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 10481742 | 238764 | 0 | None | None | None | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 518 | 11 | 2 | 7 | 6.1 | CCCSc1nnc(CSc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL350697 | 238764 | 0 | None | None | None | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 518 | 11 | 2 | 7 | 6.1 | CCCSc1nnc(CSc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 19792113 | 371436 | 0 | None | None | None | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 508 | 11 | 1 | 7 | 6.2 | CCCCOC(=O)c1cccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1007/s00044-009-9182-z | |||
| CHEMBL49930 | 371436 | 0 | None | None | None | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 508 | 11 | 1 | 7 | 6.2 | CCCCOC(=O)c1cccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1007/s00044-009-9182-z | |||
| 10322185 | 43786 | 0 | None | None | None | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 427 | 5 | 1 | 5 | 5.6 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(Cl)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL130275 | 43786 | 0 | None | None | None | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 427 | 5 | 1 | 5 | 5.6 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(Cl)ccc2n1 | 10.1021/jm00100a007 | |||
| 24827771 | 196729 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 439 | 7 | 1 | 7 | 4.1 | CC(C)CCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL261765 | 196729 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 439 | 7 | 1 | 7 | 4.1 | CC(C)CCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 24828035 | 197245 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 454 | 8 | 2 | 8 | 3.9 | CCCCn1c(=O)c2ccc(NC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL265958 | 197245 | 0 | None | None | None | Rat | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 454 | 8 | 2 | 8 | 3.9 | CCCCn1c(=O)c2ccc(NC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 1549111 | 45716 | 80 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 180 | 2 | 3 | 3 | 1.2 | O=C(O)/C=C\c1ccc(O)c(O)c1 | 10.1021/acs.jmedchem.1c00123 | |||
| 689043 | 45716 | 80 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 180 | 2 | 3 | 3 | 1.2 | O=C(O)/C=C\c1ccc(O)c(O)c1 | 10.1021/acs.jmedchem.1c00123 | |||
| CHEMBL1320034 | 45716 | 80 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 180 | 2 | 3 | 3 | 1.2 | O=C(O)/C=C\c1ccc(O)c(O)c1 | 10.1021/acs.jmedchem.1c00123 | |||
| CHEMBL145 | 45716 | 80 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 180 | 2 | 3 | 3 | 1.2 | O=C(O)/C=C\c1ccc(O)c(O)c1 | 10.1021/acs.jmedchem.1c00123 | |||
| DB01880 | 45716 | 80 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 180 | 2 | 3 | 3 | 1.2 | O=C(O)/C=C\c1ccc(O)c(O)c1 | 10.1021/acs.jmedchem.1c00123 | |||
| 18655106 | 447627 | 0 | None | None | None | Rabbit | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 464 | 10 | 0 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL59854 | 447627 | 0 | None | None | None | Rabbit | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 464 | 10 | 0 | 2 | 6.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)CC1 | 10.1016/S0960-894X(01)81007-6 | |||
| 76310606 | 214940 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCc1nc2cc(C(=O)NC(CC)c3ccccc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115236 | 214940 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCc1nc2cc(C(=O)NC(CC)c3ccccc3)ccc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| 127036106 | 273814 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734949 | 273814 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44275144 | 194079 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 496 | 9 | 1 | 8 | 4.7 | CCCCc1nc2cc(OC)c(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24688 | 194079 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 496 | 9 | 1 | 8 | 4.7 | CCCCc1nc2cc(OC)c(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44275144 | 194079 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 496 | 9 | 1 | 8 | 4.7 | CCCCc1nc2cc(OC)c(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL24688 | 194079 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 496 | 9 | 1 | 8 | 4.7 | CCCCc1nc2cc(OC)c(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 9896251 | 199018 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 682 | 12 | 1 | 9 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1021/jm020138n | |||
| CHEMBL278176 | 199018 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 682 | 12 | 1 | 9 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1021/jm020138n | |||
| 127034758 | 273816 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 681 | 12 | 1 | 8 | 7.7 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)cc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1039/C4MD00499J | |||
| CHEMBL3734968 | 273816 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 681 | 12 | 1 | 8 | 7.7 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)cc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 | 10.1039/C4MD00499J | |||
| 9913391 | 104396 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 488 | 8 | 1 | 7 | 5.7 | CCCCc1nn2c(C)c(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157980 | 104396 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 488 | 8 | 1 | 7 | 5.7 | CCCCc1nn2c(C)c(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 73357017 | 183438 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 483 | 10 | 2 | 4 | 6.2 | CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435831 | 183438 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 483 | 10 | 2 | 4 | 6.2 | CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | |||
| 10027148 | 235556 | 0 | None | None | None | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 421 | 6 | 1 | 5 | 5.5 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(C)cccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL337017 | 235556 | 0 | None | None | None | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 421 | 6 | 1 | 5 | 5.5 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(C)cccc2n1 | 10.1021/jm00100a007 | |||
| 44377262 | 119947 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 450 | 8 | 0 | 8 | 4.4 | CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL164617 | 119947 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 450 | 8 | 0 | 8 | 4.4 | CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10437270 | 217035 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 538 | 9 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL318042 | 217035 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 538 | 9 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1021/jm00043a020 | |||
| 10416422 | 474853 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 620 | 9 | 1 | 7 | 5.8 | CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97295 | 474853 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 620 | 9 | 1 | 7 | 5.8 | CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 44404967 | 272856 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 680 | 12 | 1 | 8 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 | 10.1021/jm058225d | |||
| CHEMBL372814 | 272856 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 680 | 12 | 1 | 8 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 | 10.1021/jm058225d | |||
| 53309129 | 136106 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 449 | 5 | 1 | 6 | 5.4 | CCCc1nc2c(C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801714 | 136106 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 449 | 5 | 1 | 6 | 5.4 | CCCc1nc2c(C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 71521416 | 177704 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 538 | 6 | 1 | 8 | 5.1 | CCc1nc2ccn(Cc3ccccc3C#N)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322445 | 177704 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 538 | 6 | 1 | 8 | 5.1 | CCc1nc2ccn(Cc3ccccc3C#N)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 76322690 | 175916 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 569 | 12 | 2 | 10 | 5.3 | CCCCc1nnc(SCc2ccccc2[N+](=O)[O-])n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237594 | 175916 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 569 | 12 | 2 | 10 | 5.3 | CCCCc1nnc(SCc2ccccc2[N+](=O)[O-])n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10055421 | 104641 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 526 | 11 | 1 | 9 | 5.7 | CCCCc1nnc(SCc2ccccc2[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL158188 | 104641 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 526 | 11 | 1 | 9 | 5.7 | CCCCc1nnc(SCc2ccccc2[N+](=O)[O-])n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 15698058 | 370374 | 0 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 412 | 8 | 2 | 4 | 5.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL49170 | 370374 | 0 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 412 | 8 | 2 | 4 | 5.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 14950501 | 175963 | 0 | None | None | None | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 371 | 5 | 1 | 5 | 4.4 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL22387 | 175963 | 0 | None | None | None | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 371 | 5 | 1 | 5 | 4.4 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C)c(C)n1 | 10.1021/jm00061a016 | |||
| 15698058 | 370374 | 0 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 412 | 8 | 2 | 4 | 5.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL49170 | 370374 | 0 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 412 | 8 | 2 | 4 | 5.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 15355266 | 387063 | 0 | None | None | None | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2cc(C)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL53074 | 387063 | 0 | None | None | None | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2cc(C)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44358503 | 61209 | 0 | None | None | None | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 523 | 5 | 2 | 6 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2Nc3ccccc3S(=O)(=O)N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL136911 | 61209 | 0 | None | None | None | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 523 | 5 | 2 | 6 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2Nc3ccccc3S(=O)(=O)N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 10455118 | 235354 | 0 | None | None | None | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 389 | 4 | 1 | 4 | 5.6 | Cc1cc(/C=C/c2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL336056 | 235354 | 0 | None | None | None | Guinea pig | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 389 | 4 | 1 | 4 | 5.6 | Cc1cc(/C=C/c2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 11757357 | 474846 | 0 | None | None | None | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 552 | 9 | 1 | 6 | 5.8 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97273 | 474846 | 0 | None | None | None | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 552 | 9 | 1 | 6 | 5.8 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| 19792113 | 371436 | 0 | None | None | None | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 508 | 11 | 1 | 7 | 6.2 | CCCCOC(=O)c1cccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1007/s00044-009-9182-z | |||
| CHEMBL49930 | 371436 | 0 | None | None | None | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 508 | 11 | 1 | 7 | 6.2 | CCCCOC(=O)c1cccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1007/s00044-009-9182-z | |||
| 15355266 | 387063 | 0 | None | None | None | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2cc(C)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL53074 | 387063 | 0 | None | None | None | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2cc(C)cc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792097 | 201746 | 0 | None | None | None | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 4.4 | CCCCc1nc2c(C(N)=O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL298950 | 201746 | 0 | None | None | None | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 4.4 | CCCCc1nc2c(C(N)=O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 15654717 | 202704 | 0 | None | None | None | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL304360 | 202704 | 0 | None | None | None | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 19792097 | 201746 | 0 | None | None | None | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 4.4 | CCCCc1nc2c(C(N)=O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL298950 | 201746 | 0 | None | None | None | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 451 | 8 | 2 | 6 | 4.4 | CCCCc1nc2c(C(N)=O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 9894381 | 202140 | 0 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 574 | 8 | 1 | 7 | 7.0 | CCCCc1nc2ccc(C3CCC4CCCCC4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL301827 | 202140 | 0 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 574 | 8 | 1 | 7 | 7.0 | CCCCc1nc2ccc(C3CCC4CCCCC4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 164625885 | 369538 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 969 | 22 | 11 | 11 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| CHEMBL4873899 | 369538 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 969 | 22 | 11 | 11 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2cc(O)ccc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| 73352461 | 183437 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 469 | 9 | 2 | 4 | 5.9 | CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435830 | 183437 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 469 | 9 | 2 | 4 | 5.9 | CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)O)cc3)c2c1 | 10.1016/j.ejmech.2013.08.014 | |||
| 176251201 | 466706 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 368 | 5 | 1 | 5 | 2.9 | CCCCC(=O)N1CCC2(CC1)CCN(c1ccccc1-c1nnn[nH]1)C2 | 10.1021/acs.jmedchem.4c01617 | |||
| CHEMBL6152464 | 466706 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 368 | 5 | 1 | 5 | 2.9 | CCCCC(=O)N1CCC2(CC1)CCN(c1ccccc1-c1nnn[nH]1)C2 | 10.1021/acs.jmedchem.4c01617 | |||
| 176251201 | 466706 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 368 | 5 | 1 | 5 | 2.9 | CCCCC(=O)N1CCC2(CC1)CCN(c1ccccc1-c1nnn[nH]1)C2 | 10.1021/acs.jmedchem.4c01617 | |||
| CHEMBL6152464 | 466706 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 368 | 5 | 1 | 5 | 2.9 | CCCCC(=O)N1CCC2(CC1)CCN(c1ccccc1-c1nnn[nH]1)C2 | 10.1021/acs.jmedchem.4c01617 | |||
| 127035247 | 273956 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 549 | 9 | 2 | 5 | 7.0 | CSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736338 | 273956 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 549 | 9 | 2 | 5 | 7.0 | CSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 19792093 | 202038 | 0 | None | None | None | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 480 | 9 | 1 | 7 | 5.5 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL301072 | 202038 | 0 | None | None | None | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 480 | 9 | 1 | 7 | 5.5 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10030665 | 102121 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL155948 | 102121 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10369225 | 102255 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL156084 | 102255 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956766 | 216634 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 471 | 7 | 1 | 7 | 4.5 | CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL315128 | 216634 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 471 | 7 | 1 | 7 | 4.5 | CCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 10030665 | 102121 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155948 | 102121 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10369225 | 102255 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156084 | 102255 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10259265 | 219585 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL323506 | 219585 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 713 | 12 | 2 | 9 | 7.0 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 15171393 | 176834 | 0 | None | None | None | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 447 | 7 | 1 | 5 | 5.7 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(Cc2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL23006 | 176834 | 0 | None | None | None | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 447 | 7 | 1 | 5 | 5.7 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(Cc2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| 14950512 | 200015 | 0 | None | None | None | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 511 | 7 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(I)c(CC)n1 | 10.1021/jm00061a016 | |||
| CHEMBL285560 | 200015 | 0 | None | None | None | Guinea pig | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 511 | 7 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(I)c(CC)n1 | 10.1021/jm00061a016 | |||
| 44305409 | 467890 | 0 | None | None | None | Bovine | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 625 | 12 | 2 | 8 | 4.8 | CCCc1cc(=O)n(CCNC(=O)C(c2ccccc2)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL62314 | 467890 | 0 | None | None | None | Bovine | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 625 | 12 | 2 | 8 | 4.8 | CCCc1cc(=O)n(CCNC(=O)C(c2ccccc2)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 19385623 | 103670 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 429 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15730 | 103670 | 0 | None | None | None | Rabbit | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 429 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C)c1 | 10.1016/0960-894X(95)00185-V | |||
| 10371118 | 39409 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 586 | 13 | 0 | 8 | 5.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(=O)OC)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL121733 | 39409 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 586 | 13 | 0 | 8 | 5.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(=O)OC)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10415119 | 236911 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 548 | 13 | 0 | 7 | 5.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2cccs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL340605 | 236911 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 548 | 13 | 0 | 7 | 5.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2cccs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10030426 | 40505 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 548 | 13 | 0 | 7 | 5.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2ccsc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL124144 | 40505 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 548 | 13 | 0 | 7 | 5.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2ccsc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 1610 | 7967 | 67 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| 3941 | 7967 | 67 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| 3961 | 7967 | 67 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| 44315304 | 469877 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL76821 | 469877 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 663 | 10 | 2 | 8 | 6.1 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC=C(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 76319035 | 175933 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 541 | 11 | 3 | 8 | 5.4 | CCCCc1nnc(NCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237611 | 175933 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 541 | 11 | 3 | 8 | 5.4 | CCCCc1nnc(NCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 15171409 | 473269 | 0 | None | None | None | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 5.0 | CCc1cc(OCc2ccc(-c3ccc(OC)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL87034 | 473269 | 0 | None | None | None | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 5.0 | CCc1cc(OCc2ccc(-c3ccc(OC)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 44348042 | 40659 | 0 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCCC2 | 10.1016/S0960-894X(01)80914-8 | |||
| CHEMBL124449 | 40659 | 0 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCCC2 | 10.1016/S0960-894X(01)80914-8 | |||
| 127028595 | 274770 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 616 | 11 | 3 | 7 | 5.9 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3753047 | 274770 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 616 | 11 | 3 | 7 | 5.9 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 9986861 | 238410 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 498 | 10 | 2 | 7 | 5.8 | CCCCc1nnc(NCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347236 | 238410 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 498 | 10 | 2 | 7 | 5.8 | CCCCc1nnc(NCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44438868 | 182800 | 0 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 427 | 6 | 1 | 8 | 3.4 | CCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL241684 | 182800 | 0 | None | None | None | Bovine | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 427 | 6 | 1 | 8 | 3.4 | CCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 10412769 | 44101 | 0 | None | None | None | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 441 | 6 | 1 | 5 | 5.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(Cl)c2n1 | 10.1021/jm00100a007 | |||
| CHEMBL130540 | 44101 | 0 | None | None | None | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 441 | 6 | 1 | 5 | 5.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(Cl)c2n1 | 10.1021/jm00100a007 | |||
| 10049787 | 46294 | 0 | None | None | None | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 421 | 6 | 1 | 5 | 5.5 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(C)cc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL132509 | 46294 | 0 | None | None | None | Guinea pig | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 421 | 6 | 1 | 5 | 5.5 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(C)cc2n1 | 10.1021/jm00100a007 | |||
| 168288304 | 374436 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 806 | 14 | 5 | 15 | 6.8 | CCCCc1nc(Cl)c(COC(=O)CCC(=O)Oc2cc(-c3oc4cc(O)cc(O)c4c(=O)c3O)ccc2O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2021.114068 | |||
| CHEMBL5192190 | 374436 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 806 | 14 | 5 | 15 | 6.8 | CCCCc1nc(Cl)c(COC(=O)CCC(=O)Oc2cc(-c3oc4cc(O)cc(O)c4c(=O)c3O)ccc2O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2021.114068 | |||
| 168293707 | 375203 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 806 | 14 | 5 | 15 | 6.8 | CCCCc1nc(Cl)c(COC(=O)CCC(=O)Oc2ccc(-c3oc4cc(O)cc(O)c4c(=O)c3O)cc2O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2021.114068 | |||
| CHEMBL5203983 | 375203 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 806 | 14 | 5 | 15 | 6.8 | CCCCc1nc(Cl)c(COC(=O)CCC(=O)Oc2ccc(-c3oc4cc(O)cc(O)c4c(=O)c3O)cc2O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2021.114068 | |||
| 19385652 | 100784 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 459 | 9 | 1 | 6 | 5.3 | CCOc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15458 | 100784 | 0 | None | None | None | Rabbit | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 459 | 9 | 1 | 6 | 5.3 | CCOc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| 10456700 | 238396 | 0 | None | None | None | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2ccncc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL347050 | 238396 | 0 | None | None | None | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2ccncc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44459583 | 184068 | 0 | None | None | None | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2c(C)cccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL24499 | 184068 | 0 | None | None | None | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2c(C)cccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 44285212 | 297123 | 1 | None | None | None | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 546 | 7 | 1 | 5 | 6.3 | O=C1N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(c2ccccc2)=NC1(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL39542 | 297123 | 1 | None | None | None | Rat | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 546 | 7 | 1 | 5 | 6.3 | O=C1N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(c2ccccc2)=NC1(c1ccccc1)c1ccccc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 10456700 | 238396 | 0 | None | None | None | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2ccncc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347050 | 238396 | 0 | None | None | None | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2ccncc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44563174 | 348471 | 0 | None | None | None | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 536 | 7 | 1 | 5 | 8.0 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncc[nH]2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| CHEMBL455286 | 348471 | 0 | None | None | None | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 536 | 7 | 1 | 5 | 8.0 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncc[nH]2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| 19792093 | 202038 | 0 | None | None | None | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 480 | 9 | 1 | 7 | 5.5 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL301072 | 202038 | 0 | None | None | None | Bovine | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 480 | 9 | 1 | 7 | 5.5 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44303888 | 468310 | 0 | None | None | None | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 552 | 12 | 2 | 4 | 5.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)O)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL64674 | 468310 | 0 | None | None | None | Rabbit | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 552 | 12 | 2 | 4 | 5.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(C(=O)O)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 44298775 | 404431 | 0 | None | None | None | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 410 | 5 | 1 | 7 | 3.1 | COc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL57090 | 404431 | 0 | None | None | None | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 410 | 5 | 1 | 7 | 3.1 | COc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 10620305 | 24409 | 0 | None | None | None | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 388 | 7 | 2 | 6 | 3.4 | CCCc1nc(C(=O)O)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL115560 | 24409 | 0 | None | None | None | Bovine | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 388 | 7 | 2 | 6 | 3.4 | CCCc1nc(C(=O)O)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 73349423 | 183429 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 441 | 7 | 2 | 4 | 5.7 | CCCc1nc2c(C)cc(NC(C)=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435822 | 183429 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 441 | 7 | 2 | 4 | 5.7 | CCCc1nc2c(C)cc(NC(C)=O)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 24828294 | 196185 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 411 | 7 | 1 | 7 | 4.3 | CCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc21 | 10.1021/jm7011563 | |||
| CHEMBL258891 | 196185 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 411 | 7 | 1 | 7 | 4.3 | CCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc21 | 10.1021/jm7011563 | |||
| 10347373 | 101786 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2cccc(C(=O)O)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL155661 | 101786 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2cccc(C(=O)O)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 11755714 | 238911 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.9 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL352235 | 238911 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.9 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956744 | 470948 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2cccc(OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL86255 | 470948 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2cccc(OC)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44459896 | 196628 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 470 | 7 | 1 | 6 | 5.3 | CCCCc1nc2cc(Cl)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL26113 | 196628 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 470 | 7 | 1 | 6 | 5.3 | CCCCc1nc2cc(Cl)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 10347373 | 101786 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2cccc(C(=O)O)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155661 | 101786 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2cccc(C(=O)O)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 11755714 | 238911 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.9 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL352235 | 238911 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.9 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44377263 | 329814 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 416 | 8 | 0 | 8 | 3.7 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL422200 | 329814 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 416 | 8 | 0 | 8 | 3.7 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10417195 | 218660 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 685 | 13 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL321313 | 218660 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 685 | 13 | 2 | 9 | 6.2 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OCC)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 44315058 | 142697 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL194608 | 142697 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 637 | 10 | 3 | 8 | 5.6 | Cc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44372814 | 238506 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 672 | 11 | 2 | 6 | 6.7 | CCCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1021/jm9504722 | |||
| CHEMBL348157 | 238506 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 672 | 11 | 2 | 6 | 6.7 | CCCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)O)C1 | 10.1021/jm9504722 | |||
| 10411441 | 105022 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 449 | 7 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15850 | 105022 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 449 | 7 | 1 | 5 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| 44381431 | 121290 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 578 | 11 | 1 | 9 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL168346 | 121290 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 578 | 11 | 1 | 9 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3ccc([N+](=O)[O-])cc3c2=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 53309273 | 136110 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 463 | 5 | 1 | 6 | 5.6 | CCc1c(C)nc2c(nc(CC)n2[C@H]2CCc3cc(-c4ccccc4-c4nnn[nH]4)ccc32)c1C | 10.1021/jm200409s | |||
| CHEMBL1801737 | 136110 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 463 | 5 | 1 | 6 | 5.6 | CCc1c(C)nc2c(nc(CC)n2[C@H]2CCc3cc(-c4ccccc4-c4nnn[nH]4)ccc32)c1C | 10.1021/jm200409s | |||
| 10006693 | 40922 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 514 | 11 | 1 | 6 | 5.4 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10324179 | 40922 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 514 | 11 | 1 | 6 | 5.4 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125454 | 40922 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 514 | 11 | 1 | 6 | 5.4 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL333126 | 40922 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 514 | 11 | 1 | 6 | 5.4 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 1610 | 7967 | 67 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00319-O | |||
| 3941 | 7967 | 67 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00319-O | |||
| 3961 | 7967 | 67 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00319-O | |||
| 44297010 | 201744 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 577 | 8 | 1 | 10 | 4.1 | CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)OC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL298943 | 201744 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 577 | 8 | 1 | 10 | 4.1 | CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)OC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 19102815 | 474743 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 672 | 11 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL96554 | 474743 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 672 | 11 | 1 | 8 | 7.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1 | 10.1016/S0960-894X(01)80595-3 | |||
| 44296547 | 371551 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 380 | 7 | 3 | 5 | 3.1 | CCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL50092 | 371551 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 380 | 7 | 3 | 5 | 3.1 | CCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 2583 | 8231 | 75 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| 592 | 8231 | 75 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| 65999 | 8231 | 75 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL1017 | 8231 | 75 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| DB00966 | 8231 | 75 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmc.2012.05.056 | |||
| 1610 | 7967 | 67 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a016 | |||
| 3941 | 7967 | 67 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a016 | |||
| 3961 | 7967 | 67 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a016 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00067a016 | |||
| 15654750 | 213322 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 456 | 7 | 2 | 7 | 4.5 | CSCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL308651 | 213322 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 456 | 7 | 2 | 7 | 4.5 | CSCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 44563176 | 335982 | 0 | None | None | None | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 537 | 7 | 1 | 6 | 7.4 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncn[nH]2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| CHEMBL446314 | 335982 | 0 | None | None | None | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 537 | 7 | 1 | 6 | 7.4 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncn[nH]2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| 19792183 | 201889 | 0 | None | None | None | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2cc(Cl)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299994 | 201889 | 0 | None | None | None | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2cc(Cl)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44210317 | 203259 | 0 | None | None | None | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 532 | 5 | 1 | 3 | 5.3 | CCCCc1nc2ccccc2n1Cc1cc(I)c(O)c(I)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL308424 | 203259 | 0 | None | None | None | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 532 | 5 | 1 | 3 | 5.3 | CCCCc1nc2ccccc2n1Cc1cc(I)c(O)c(I)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 19792183 | 201889 | 0 | None | None | None | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2cc(Cl)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299994 | 201889 | 0 | None | None | None | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2cc(Cl)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 127034757 | 273840 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 679 | 12 | 2 | 7 | 7.5 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735265 | 273840 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 679 | 12 | 2 | 7 | 7.5 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 127036104 | 273909 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 555 | 9 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)N[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735910 | 273909 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 555 | 9 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)N[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 127036294 | 273798 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 555 | 9 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)N[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734815 | 273798 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 555 | 9 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)N[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 24828567 | 196650 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 410 | 6 | 1 | 5 | 4.4 | CCCC1c2ncccc2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL261248 | 196650 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 410 | 6 | 1 | 5 | 4.4 | CCCC1c2ncccc2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 44296953 | 387239 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.7 | CCCCc1nc2ccc([C@H]3C4CCCC4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL53803 | 387239 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.7 | CCCCc1nc2ccc([C@H]3C4CCCC4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 127035514 | 273865 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735446 | 273865 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 176251170 | 466529 | 0 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 359 | 4 | 1 | 7 | 3.0 | CCc1nnc(N2Cc3ccc(-c4ccccc4-c4nnn[nH]4)cc3C2)o1 | 10.1021/acs.jmedchem.4c01617 | |||
| CHEMBL6147980 | 466529 | 0 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 359 | 4 | 1 | 7 | 3.0 | CCc1nnc(N2Cc3ccc(-c4ccccc4-c4nnn[nH]4)cc3C2)o1 | 10.1021/acs.jmedchem.4c01617 | |||
| 10371295 | 232567 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 596 | 12 | 0 | 6 | 6.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(F)(F)F)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL332152 | 232567 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 596 | 12 | 0 | 6 | 6.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(F)(F)F)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 14956745 | 473248 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccc(C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL86906 | 473248 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccc(C)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44307122 | 468048 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 349 | 3 | 1 | 4 | 4.7 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(O)c(Cl)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL63144 | 468048 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 349 | 3 | 1 | 4 | 4.7 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(O)c(Cl)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 9823146 | 43217 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n(CCCC)n1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL12909 | 43217 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n(CCCC)n1 | 10.1016/j.bmc.2010.10.043 | |||
| 127035410 | 273830 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 557 | 8 | 1 | 8 | 5.7 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C#N)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
| CHEMBL3735155 | 273830 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 557 | 8 | 1 | 8 | 5.7 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C#N)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
| 70692693 | 157873 | 0 | None | None | None | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 500 | 8 | 1 | 6 | 6.1 | CCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058369 | 157873 | 0 | None | None | None | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 500 | 8 | 1 | 6 | 6.1 | CCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 44438880 | 182782 | 0 | None | None | None | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 427 | 7 | 2 | 7 | 3.7 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL241523 | 182782 | 0 | None | None | None | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 427 | 7 | 2 | 7 | 3.7 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 44297143 | 201382 | 0 | None | None | None | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 547 | 8 | 1 | 8 | 5.3 | CCCCc1nc2ccc([C@@H]3[C@H]4CCCN3OC4)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL296173 | 201382 | 0 | None | None | None | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 547 | 8 | 1 | 8 | 5.3 | CCCCc1nc2ccc([C@@H]3[C@H]4CCCN3OC4)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 9886863 | 77410 | 0 | None | None | None | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 393 | 5 | 1 | 5 | 5.0 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL142380 | 77410 | 0 | None | None | None | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 393 | 5 | 1 | 5 | 5.0 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 10078800 | 218769 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL321531 | 218769 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 751 | 13 | 2 | 8 | 7.6 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 9886863 | 77410 | 0 | None | None | None | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 393 | 5 | 1 | 5 | 5.0 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00061a016 | |||
| CHEMBL142380 | 77410 | 0 | None | None | None | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 393 | 5 | 1 | 5 | 5.0 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00061a016 | |||
| 19811543 | 468390 | 0 | None | None | None | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 444 | 9 | 1 | 7 | 3.7 | CCCCn1c(=O)cc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL65224 | 468390 | 0 | None | None | None | Bovine | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 444 | 9 | 1 | 7 | 3.7 | CCCCn1c(=O)cc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1016/0960-894X(95)00370-9 | |||
| 19385586 | 102967 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 479 | 8 | 1 | 6 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(OC)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15669 | 102967 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 479 | 8 | 1 | 6 | 5.5 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(OC)c1 | 10.1016/0960-894X(95)00185-V | |||
| 10049400 | 311399 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 449 | 8 | 1 | 5 | 5.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL40381 | 311399 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 449 | 8 | 1 | 5 | 5.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2Cl)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 44381603 | 121897 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 532 | 8 | 2 | 7 | 3.8 | CCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169798 | 121897 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 532 | 8 | 2 | 7 | 3.8 | CCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 1610 | 7967 | 67 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/C5MD00169B | |||
| 3941 | 7967 | 67 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/C5MD00169B | |||
| 3961 | 7967 | 67 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/C5MD00169B | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/C5MD00169B | |||
| 1610 | 7967 | 67 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2013.08.014 | |||
| 3941 | 7967 | 67 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2013.08.014 | |||
| 3961 | 7967 | 67 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2013.08.014 | |||
| 1610 | 7967 | 67 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | |||
| 3941 | 7967 | 67 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | |||
| 3961 | 7967 | 67 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.01.009 | |||
| 1610 | 7967 | 67 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| 3941 | 7967 | 67 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| 3961 | 7967 | 67 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.05.056 | |||
| 10323969 | 40296 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 507 | 9 | 0 | 8 | 4.3 | CCCCc1ncc(/C=C2/C(=O)N(C)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL123091 | 40296 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 507 | 9 | 0 | 8 | 4.3 | CCCCc1ncc(/C=C2/C(=O)N(C)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 70682146 | 157989 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL2058860 | 157989 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10325767 | 222531 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 573 | 13 | 0 | 8 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331219 | 222531 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 573 | 13 | 0 | 8 | 5.6 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 53309275 | 136112 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 463 | 5 | 1 | 6 | 5.8 | CCc1cc(C)c2nc(C(C)C)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| CHEMBL1801739 | 136112 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 463 | 5 | 1 | 6 | 5.8 | CCc1cc(C)c2nc(C(C)C)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| 44306647 | 201046 | 0 | None | None | None | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 425 | 6 | 1 | 7 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL293846 | 201046 | 0 | None | None | None | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 425 | 6 | 1 | 7 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| 127034756 | 273800 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 679 | 12 | 2 | 7 | 7.5 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3734829 | 273800 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 679 | 12 | 2 | 7 | 7.5 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 15780064 | 199817 | 0 | None | None | None | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 613 | 10 | 1 | 8 | 6.7 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL284123 | 199817 | 0 | None | None | None | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 613 | 10 | 1 | 8 | 6.7 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 1610 | 7967 | 67 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.040 | |||
| 3941 | 7967 | 67 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.040 | |||
| 3961 | 7967 | 67 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.040 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2008.10.040 | |||
| 44438901 | 182783 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 389 | 6 | 2 | 5 | 3.8 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL241529 | 182783 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 389 | 6 | 2 | 5 | 3.8 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 10390316 | 45849 | 0 | None | None | None | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 441 | 6 | 1 | 5 | 5.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(Cl)cc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL132115 | 45849 | 0 | None | None | None | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 441 | 6 | 1 | 5 | 5.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(Cl)cc2n1 | 10.1021/jm00100a007 | |||
| 1610 | 7967 | 67 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| 3941 | 7967 | 67 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| 3961 | 7967 | 67 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/0960-894X(95)00370-9 | |||
| 10096347 | 102656 | 0 | None | None | None | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.4 | CCCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL156449 | 102656 | 0 | None | None | None | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.4 | CCCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44298758 | 386641 | 0 | None | None | None | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 452 | 7 | 1 | 7 | 4.2 | CCCOc1nc2ccc(C)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL52824 | 386641 | 0 | None | None | None | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 452 | 7 | 1 | 7 | 4.2 | CCCOc1nc2ccc(C)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 10096347 | 102656 | 0 | None | None | None | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.4 | CCCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156449 | 102656 | 0 | None | None | None | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 472 | 9 | 2 | 6 | 5.4 | CCCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 54768660 | 137417 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 521 | 8 | 1 | 8 | 4.9 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1cccc(C)c1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL1824000 | 137417 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 521 | 8 | 1 | 8 | 4.9 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1cccc(C)c1 | 10.1016/j.ejmech.2011.05.056 | |||
| 44309040 | 203037 | 0 | None | None | None | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 370 | 7 | 1 | 7 | 3.9 | CCCCc1nc2ccccc2n1Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL306670 | 203037 | 0 | None | None | None | Bovine | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 370 | 7 | 1 | 7 | 3.9 | CCCCc1nc2ccccc2n1Cc1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 44459707 | 184150 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 518 | 8 | 2 | 7 | 5.1 | CCCCc1nc2cc(C3=NNC(=O)CC3C)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| CHEMBL24550 | 184150 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 518 | 8 | 2 | 7 | 5.1 | CCCCc1nc2cc(C3=NNC(=O)CC3C)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| 127028618 | 274682 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 536 | 9 | 3 | 7 | 4.9 | CCCc1nc2c(C)cc(C(=O)NC(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752198 | 274682 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 536 | 9 | 3 | 7 | 4.9 | CCCc1nc2c(C)cc(C(=O)NC(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 127034903 | 273879 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)NC[C@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735641 | 273879 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)NC[C@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 24827902 | 313622 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 459 | 7 | 1 | 7 | 4.5 | CCCCn1c(=O)c2ccc(Cl)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL408227 | 313622 | 0 | None | None | None | Rat | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 459 | 7 | 1 | 7 | 4.5 | CCCCn1c(=O)c2ccc(Cl)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 76325126 | 214941 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.1 | CCCc1nn2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115241 | 214941 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.1 | CCCc1nn2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| 71653152 | 180009 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 593 | 11 | 2 | 7 | 5.9 | CCCCc1n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc[n+]1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2365924 | 180009 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 593 | 11 | 2 | 7 | 5.9 | CCCCc1n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc[n+]1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 76311800 | 175912 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 538 | 11 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237590 | 175912 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 538 | 11 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956784 | 216222 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 447 | 9 | 1 | 9 | 2.5 | CCCCc1nn(CC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL314179 | 216222 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 447 | 9 | 1 | 9 | 2.5 | CCCCc1nn(CC(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 14956764 | 470864 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 541 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL85541 | 470864 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 541 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 9889557 | 197375 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 442 | 7 | 3 | 7 | 2.7 | CCCCc1nc2c(=O)[nH][nH]c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL267056 | 197375 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 442 | 7 | 3 | 7 | 2.7 | CCCCc1nc2c(=O)[nH][nH]c(=O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 10028751 | 329831 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 495 | 10 | 1 | 7 | 6.1 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL422333 | 329831 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 495 | 10 | 1 | 7 | 6.1 | CCCCc1nnc(SCc2ccccc2C)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10010164 | 236244 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL339806 | 236244 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.0 | CCCCNC(=O)c1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10393086 | 40404 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 562 | 12 | 0 | 6 | 6.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(Cl)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL123670 | 40404 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 562 | 12 | 0 | 6 | 6.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(Cl)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 11758470 | 222469 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 612 | 12 | 0 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(Br)s2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331121 | 222469 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 612 | 12 | 0 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(Br)s2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 15780091 | 239618 | 0 | None | None | None | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 618 | 9 | 1 | 8 | 6.1 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccncc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL35638 | 239618 | 0 | None | None | None | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 618 | 9 | 1 | 8 | 6.1 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccncc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 9982960 | 238558 | 0 | None | None | None | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 488 | 8 | 1 | 7 | 5.7 | CCCCc1nn2c(-c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL348616 | 238558 | 0 | None | None | None | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 488 | 8 | 1 | 7 | 5.7 | CCCCc1nn2c(-c3ccccc3)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10475047 | 236291 | 0 | None | None | None | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 383 | 6 | 1 | 3 | 5.7 | CCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL339846 | 236291 | 0 | None | None | None | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 383 | 6 | 1 | 3 | 5.7 | CCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 10161446 | 202830 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 456 | 7 | 2 | 7 | 4.7 | CCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL305190 | 202830 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 456 | 7 | 2 | 7 | 4.7 | CCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 15654758 | 468827 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 425 | 6 | 3 | 7 | 3.7 | CNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL68597 | 468827 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 425 | 6 | 3 | 7 | 3.7 | CNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 15654742 | 469017 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 438 | 7 | 2 | 6 | 4.6 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL70074 | 469017 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 438 | 7 | 2 | 6 | 4.6 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 19385675 | 104607 | 0 | None | None | None | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 445 | 8 | 1 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(OC)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15816 | 104607 | 0 | None | None | None | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 445 | 8 | 1 | 6 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(OC)c1 | 10.1016/0960-894X(95)00185-V | |||
| 10004159 | 238295 | 0 | None | None | None | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2cccnc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL345894 | 238295 | 0 | None | None | None | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2cccnc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10004159 | 238295 | 0 | None | None | None | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2cccnc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345894 | 238295 | 0 | None | None | None | Rabbit | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 455 | 9 | 2 | 6 | 4.7 | CCCCc1nnc(-c2cccnc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 2171 | 193979 | 62 | None | None | None | Bovine | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 334 | 3 | 2 | 4 | 3.1 | COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3[nH]2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| 4823 | 193979 | 62 | None | None | None | Bovine | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 334 | 3 | 2 | 4 | 3.1 | COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3[nH]2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| CHEMBL24646 | 193979 | 62 | None | None | None | Bovine | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 334 | 3 | 2 | 4 | 3.1 | COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3[nH]2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| DB11450 | 193979 | 62 | None | None | None | Bovine | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 334 | 3 | 2 | 4 | 3.1 | COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3[nH]2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| 164620345 | 369489 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 1084 | 26 | 13 | 13 | 0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| CHEMBL4873167 | 369489 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 1084 | 26 | 13 | 13 | 0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| 44296955 | 385008 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 653 | 10 | 1 | 10 | 5.7 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)OC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL53226 | 385008 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 653 | 10 | 1 | 10 | 5.7 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)OC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 14956741 | 216703 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL315615 | 216703 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2cccc(C)c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 1610 | 7967 | 67 | None | None | None | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80295-X | |||
| 3941 | 7967 | 67 | None | None | None | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80295-X | |||
| 3961 | 7967 | 67 | None | None | None | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80295-X | |||
| 101783341 | 386177 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 391 | 4 | 1 | 4 | 4.6 | Cc1ccc(S(=O)(=O)n2c(-c3ccccc3)c(C(=O)O)c3ccccc32)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5271135 | 386177 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 391 | 4 | 1 | 4 | 4.6 | Cc1ccc(S(=O)(=O)n2c(-c3ccccc3)c(C(=O)O)c3ccccc32)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| 24827770 | 196237 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL259114 | 196237 | 0 | None | None | None | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 1610 | 7967 | 67 | None | None | None | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00100a007 | |||
| 3941 | 7967 | 67 | None | None | None | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00100a007 | |||
| 3961 | 7967 | 67 | None | None | None | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00100a007 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00100a007 | |||
| 10099830 | 218098 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 584 | 9 | 1 | 7 | 4.9 | CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL319955 | 218098 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 584 | 9 | 1 | 7 | 4.9 | CCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1021/jm00043a020 | |||
| 44315349 | 123157 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL17487 | 123157 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 1610 | 7967 | 67 | None | None | None | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00061a016 | |||
| 3941 | 7967 | 67 | None | None | None | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00061a016 | |||
| 3961 | 7967 | 67 | None | None | None | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00061a016 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Guinea pig | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00061a016 | |||
| 15287891 | 251763 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 459 | 10 | 1 | 6 | 5.3 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2OCC)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL36218 | 251763 | 0 | None | None | None | Rabbit | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 459 | 10 | 1 | 6 | 5.3 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2OCC)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 10007528 | 40182 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 542 | 12 | 0 | 6 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc(C)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122490 | 40182 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 542 | 12 | 0 | 6 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc(C)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277595 | 20654 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 621 | 9 | 0 | 10 | 5.4 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CC(=O)c4ccco4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL108190 | 20654 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 621 | 9 | 0 | 10 | 5.4 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CC(=O)c4ccco4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44294996 | 372901 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL51622 | 372901 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44296985 | 386884 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 603 | 8 | 1 | 8 | 6.9 | CCCCc1nc2ccc([C@H]3C4CCCCCCC4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL52880 | 386884 | 0 | None | None | None | Bovine | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 603 | 8 | 1 | 8 | 6.9 | CCCCc1nc2ccc([C@H]3C4CCCCCCC4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 10453972 | 46019 | 0 | None | None | None | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 369 | 5 | 1 | 3 | 5.5 | Cc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL132269 | 46019 | 0 | None | None | None | Guinea pig | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 369 | 5 | 1 | 3 | 5.5 | Cc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 44381714 | 121902 | 0 | None | None | None | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 732 | 11 | 1 | 7 | 7.6 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| CHEMBL169827 | 121902 | 0 | None | None | None | Rabbit | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 732 | 11 | 1 | 7 | 7.6 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81126-4 | |||
| 178302971 | 466996 | 0 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 435 | 7 | 1 | 5 | 5.9 | CCCCC(=O)n1cc(Cc2ccccc2)c2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/acs.jmedchem.4c01617 | |||
| CHEMBL6166097 | 466996 | 0 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 435 | 7 | 1 | 5 | 5.9 | CCCCC(=O)n1cc(Cc2ccccc2)c2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/acs.jmedchem.4c01617 | |||
| 178302971 | 466996 | 0 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 435 | 7 | 1 | 5 | 5.9 | CCCCC(=O)n1cc(Cc2ccccc2)c2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/acs.jmedchem.4c01617 | |||
| CHEMBL6166097 | 466996 | 0 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 435 | 7 | 1 | 5 | 5.9 | CCCCC(=O)n1cc(Cc2ccccc2)c2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/acs.jmedchem.4c01617 | |||
| 24827899 | 197214 | 0 | None | None | None | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 411 | 5 | 1 | 7 | 3.4 | CCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL265697 | 197214 | 0 | None | None | None | Rat | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 411 | 5 | 1 | 7 | 3.4 | CCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 44348302 | 40379 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 527 | 12 | 1 | 5 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 | 10.1021/jm00075a033 | |||
| CHEMBL123562 | 40379 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 527 | 12 | 1 | 5 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 | 10.1021/jm00075a033 | |||
| 44438870 | 182801 | 0 | None | None | None | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 469 | 9 | 1 | 8 | 4.6 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL241685 | 182801 | 0 | None | None | None | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 469 | 9 | 1 | 8 | 4.6 | CCCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 44348302 | 40379 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 527 | 12 | 1 | 5 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 | 10.1021/jm9504722 | |||
| CHEMBL123562 | 40379 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 527 | 12 | 1 | 5 | 7.3 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(CC)cc1 | 10.1021/jm9504722 | |||
| 1610 | 7967 | 67 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| 3941 | 7967 | 67 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| 3961 | 7967 | 67 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| 71521299 | 177700 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 479 | 6 | 1 | 7 | 4.8 | CCc1nc2ccn(CC(C)C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322441 | 177700 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 479 | 6 | 1 | 7 | 4.8 | CCc1nc2ccn(CC(C)C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 127036102 | 273951 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 531 | 9 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)N[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736295 | 273951 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 531 | 9 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)N[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL5075338 | 478566 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 597 | 13 | 5 | 7 | 3.5 | CCOC(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@@H](C)NC(=O)/C=C/c1ccc(O)c(O)c1 | 10.1021/acs.jmedchem.1c00123 | |||
| 70686409 | 157984 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058855 | 157984 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 71521196 | 177698 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 571 | 8 | 1 | 9 | 4.9 | CCc1nc2ccn(CC(=O)OCc3ccccc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322439 | 177698 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 571 | 8 | 1 | 9 | 4.9 | CCc1nc2ccn(CC(=O)OCc3ccccc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 10098452 | 104673 | 0 | None | None | None | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 528 | 12 | 2 | 7 | 5.6 | CCCCc1nnc(SCC(=O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL158209 | 104673 | 0 | None | None | None | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 528 | 12 | 2 | 7 | 5.6 | CCCCc1nnc(SCC(=O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10098452 | 104673 | 0 | None | None | None | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 528 | 12 | 2 | 7 | 5.6 | CCCCc1nnc(SCC(=O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL158209 | 104673 | 0 | None | None | None | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 528 | 12 | 2 | 7 | 5.6 | CCCCc1nnc(SCC(=O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 14950502 | 176567 | 0 | None | None | None | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 385 | 6 | 1 | 6 | 3.9 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C=O)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL22837 | 176567 | 0 | None | None | None | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 385 | 6 | 1 | 6 | 3.9 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C=O)c(C)n1 | 10.1021/jm00061a016 | |||
| 15654756 | 202472 | 0 | None | None | None | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 454 | 8 | 2 | 7 | 4.4 | CCCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL303955 | 202472 | 0 | None | None | None | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 454 | 8 | 2 | 7 | 4.4 | CCCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 15654741 | 468946 | 0 | None | None | None | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 410 | 5 | 2 | 6 | 3.9 | Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL69522 | 468946 | 0 | None | None | None | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 410 | 5 | 2 | 6 | 3.9 | Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 22596780 | 469306 | 4 | None | None | None | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 416 | 7 | 2 | 5 | 4.5 | CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL71954 | 469306 | 4 | None | None | None | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 416 | 7 | 2 | 5 | 4.5 | CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00067a016 | |||
| 10321914 | 238738 | 0 | None | None | None | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 458 | 8 | 2 | 6 | 5.1 | CCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL350446 | 238738 | 0 | None | None | None | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 458 | 8 | 2 | 6 | 5.1 | CCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10321914 | 238738 | 0 | None | None | None | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 458 | 8 | 2 | 6 | 5.1 | CCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL350446 | 238738 | 0 | None | None | None | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 458 | 8 | 2 | 6 | 5.1 | CCSc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 54768661 | 137418 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 535 | 8 | 1 | 8 | 5.3 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1cc(C)cc(C)c1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL1824001 | 137418 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 535 | 8 | 1 | 8 | 5.3 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1cc(C)cc(C)c1 | 10.1016/j.ejmech.2011.05.056 | |||
| 11757216 | 40504 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 547 | 12 | 0 | 8 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c(C)noc2C)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL124141 | 40504 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 547 | 12 | 0 | 8 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c(C)noc2C)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 57380649 | 142619 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 549 | 10 | 2 | 4 | 6.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945149 | 142619 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 549 | 10 | 2 | 4 | 6.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 2121583 | 47201 | 3 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 397 | 7 | 1 | 4 | 4.0 | CN(Cc1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1)C(=O)CCC(=O)O | 10.1016/j.bmc.2016.07.047 | |||
| CHEMBL1332729 | 47201 | 3 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 397 | 7 | 1 | 4 | 4.0 | CN(Cc1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1)C(=O)CCC(=O)O | 10.1016/j.bmc.2016.07.047 | |||
| 2121583 | 47201 | 3 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 397 | 7 | 1 | 4 | 4.0 | CN(Cc1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1)C(=O)CCC(=O)O | 10.1016/j.bmc.2016.07.047 | |||
| CHEMBL1332729 | 47201 | 3 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 397 | 7 | 1 | 4 | 4.0 | CN(Cc1cn(-c2ccccc2)nc1-c1ccc(Cl)cc1)C(=O)CCC(=O)O | 10.1016/j.bmc.2016.07.047 | |||
| 44274672 | 182362 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 465 | 8 | 2 | 7 | 4.7 | CCCCc1nc2ccc(NC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24053 | 182362 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 465 | 8 | 2 | 7 | 4.7 | CCCCc1nc2ccc(NC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44274824 | 199478 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 535 | 11 | 2 | 7 | 5.8 | CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL281846 | 199478 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 535 | 11 | 2 | 7 | 5.8 | CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| 14956756 | 473339 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 529 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2ccccc2Br)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87513 | 473339 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 529 | 8 | 1 | 7 | 5.0 | CCCCc1nn(-c2ccccc2Br)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 2583 | 8231 | 75 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2014.01.004 | |||
| 592 | 8231 | 75 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2014.01.004 | |||
| 65999 | 8231 | 75 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL1017 | 8231 | 75 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2014.01.004 | |||
| DB00966 | 8231 | 75 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2014.01.004 | |||
| 136401481 | 316433 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 651 | 11 | 1 | 11 | 5.7 | CCc1cc2c(=O)n(C/C(=N\OC(C)C)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| CHEMBL4114737 | 316433 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 651 | 11 | 1 | 11 | 5.7 | CCc1cc2c(=O)n(C/C(=N\OC(C)C)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3)c2s1 | nan | |||
| 44274824 | 199478 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 535 | 11 | 2 | 7 | 5.8 | CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL281846 | 199478 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 535 | 11 | 2 | 7 | 5.8 | CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80334-0 | |||
| 44311583 | 469062 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70353 | 469062 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 10209324 | 38400 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 546 | 8 | 1 | 7 | 6.2 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
| CHEMBL12013 | 38400 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 546 | 8 | 1 | 7 | 6.2 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
| 9871837 | 39101 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 535 | 10 | 2 | 7 | 4.9 | CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 | 10.1039/C4MD00499J | |||
| CHEMBL12106 | 39101 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 535 | 10 | 2 | 7 | 4.9 | CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 | 10.1039/C4MD00499J | |||
| 15222070 | 202383 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 577 | 9 | 2 | 9 | 3.8 | CCCc1nc(C(=O)N2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL303426 | 202383 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 577 | 9 | 2 | 9 | 3.8 | CCCc1nc(C(=O)N2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311662 | 202741 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 624 | 17 | 2 | 7 | 5.8 | CCCCN(Cc1nc(CCC)n(Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC)cc2)c1C(=O)O)C(=O)CCC | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL304620 | 202741 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 624 | 17 | 2 | 7 | 5.8 | CCCCN(Cc1nc(CCC)n(Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)CCC)cc2)c1C(=O)O)C(=O)CCC | 10.1016/S0960-894X(00)80076-1 | |||
| 15222094 | 203024 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 596 | 10 | 2 | 8 | 5.4 | CCCc1nc(CN2CCN(c3ccccc3Cl)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL306489 | 203024 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 596 | 10 | 2 | 8 | 5.4 | CCCc1nc(CN2CCN(c3ccccc3Cl)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311681 | 203073 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 592 | 11 | 2 | 9 | 4.8 | CCCc1nc(CN2CCN(c3ccccc3OC)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL306961 | 203073 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 592 | 11 | 2 | 9 | 4.8 | CCCc1nc(CN2CCN(c3ccccc3OC)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 15222092 | 213545 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 564 | 10 | 2 | 10 | 3.5 | CCCc1nc(CN2CCN(c3ncccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL309165 | 213545 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 564 | 10 | 2 | 10 | 3.5 | CCCc1nc(CN2CCN(c3ncccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311451 | 213821 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 576 | 10 | 2 | 8 | 5.1 | CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL309367 | 213821 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 576 | 10 | 2 | 8 | 5.1 | CCCc1nc(CN2CCN(c3ccccc3)C[C@H]2C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311497 | 332617 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 547 | 10 | 1 | 9 | 4.3 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL430997 | 332617 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 547 | 10 | 1 | 9 | 4.3 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311663 | 469117 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 561 | 10 | 2 | 7 | 5.8 | CCCc1nc(CN2CCC(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL70796 | 469117 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 561 | 10 | 2 | 7 | 5.8 | CCCc1nc(CN2CCC(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311499 | 469305 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 557 | 17 | 2 | 7 | 6.6 | CCCCCN(CCCCC)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL71953 | 469305 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 557 | 17 | 2 | 7 | 6.6 | CCCCCN(CCCCC)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1016/S0960-894X(00)80076-1 | |||
| 44311648 | 469427 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 577 | 11 | 2 | 9 | 4.5 | CCCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL72721 | 469427 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 577 | 11 | 2 | 9 | 4.5 | CCCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311758 | 469561 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 626 | 12 | 3 | 7 | 6.7 | CCCc1nc(CN(Cc2ccccc2)C(=O)Nc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL73780 | 469561 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 626 | 12 | 3 | 7 | 6.7 | CCCc1nc(CN(Cc2ccccc2)C(=O)Nc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 19742811 | 120217 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 551 | 10 | 2 | 6 | 5.4 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL165354 | 120217 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 551 | 10 | 2 | 6 | 5.4 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10077555 | 474303 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 616 | 12 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCOC)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL93956 | 474303 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 616 | 12 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCOC)cc1 | 10.1021/jm00043a020 | |||
| 10440144 | 235770 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL338342 | 235770 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 763 | 10 | 2 | 9 | 7.1 | CCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44315349 | 123157 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL17487 | 123157 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 679 | 10 | 2 | 9 | 5.1 | CCc1nc2ccc(NC(=O)N3CCOCC3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 2583 | 8231 | 75 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2019.04.030 | |||
| 592 | 8231 | 75 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2019.04.030 | |||
| 65999 | 8231 | 75 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2019.04.030 | |||
| CHEMBL1017 | 8231 | 75 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2019.04.030 | |||
| DB00966 | 8231 | 75 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.ejmech.2019.04.030 | |||
| 108185 | 3317 | 57 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| 586 | 3317 | 57 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| CHEMBL907 | 3317 | 57 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| 1037 | 7928 | 51 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 3940 | 7928 | 51 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 5281037 | 7928 | 51 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL813 | 7928 | 51 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 44285372 | 200459 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 446 | 6 | 1 | 6 | 4.3 | CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL289105 | 200459 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 446 | 6 | 1 | 6 | 4.3 | CCCC1=NC2(CCSCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 44338666 | 220477 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 551 | 9 | 1 | 8 | 5.5 | CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL326217 | 220477 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 551 | 9 | 1 | 8 | 5.5 | CCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 9850834 | 310695 | 23 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| CHEMBL39959 | 310695 | 23 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 562 | 11 | 1 | 7 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/0960-894X(96)00017-0 | |||
| 14956779 | 140932 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 445 | 8 | 1 | 7 | 4.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL19202 | 140932 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 445 | 8 | 1 | 7 | 4.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 10031067 | 200517 | 5 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/ml500427r | |||
| CHEMBL289614 | 200517 | 5 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1021/ml500427r | |||
| 127030943 | 276523 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787700 | 276523 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| 44277462 | 38673 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 665 | 11 | 2 | 10 | 5.2 | CCCCN(C(=O)c1ccc(OP(=O)(O)O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL1206522 | 38673 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 665 | 11 | 2 | 10 | 5.2 | CCCCN(C(=O)c1ccc(OP(=O)(O)O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44277548 | 199614 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 615 | 12 | 0 | 10 | 4.6 | COCCOCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL282777 | 199614 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 615 | 12 | 0 | 10 | 4.6 | COCCOCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 10479475 | 234209 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 462 | 6 | 1 | 6 | 4.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1021/jm00050a002 | |||
| CHEMBL334670 | 234209 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 462 | 6 | 1 | 6 | 4.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1021/jm00050a002 | |||
| 10393837 | 332697 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 602 | 10 | 1 | 8 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL431619 | 332697 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 602 | 10 | 1 | 8 | 5.5 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC)cc1 | 10.1021/jm00043a020 | |||
| 10462573 | 235874 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338889 | 235874 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.8 | CCCCC(=O)Nc1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10372550 | 329450 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL421478 | 329450 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 698 | 13 | 1 | 9 | 7.5 | CCCCC(=O)c1ccc(Cl)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44315344 | 214782 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311386 | 214782 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 18950607 | 103653 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 489 | 9 | 1 | 5 | 6.2 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(Cl)c1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15729 | 103653 | 0 | None | None | None | Rabbit | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 489 | 9 | 1 | 5 | 6.2 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(Cl)c1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| 10004646 | 40381 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 464 | 9 | 2 | 6 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10095986 | 40381 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 464 | 9 | 2 | 6 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL123568 | 40381 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 464 | 9 | 2 | 6 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL126037 | 40381 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 464 | 9 | 2 | 6 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 136052253 | 252547 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 624 | 10 | 1 | 11 | 4.7 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3OC)c2s1 | nan | |||
| CHEMBL3640160 | 252547 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 624 | 10 | 1 | 11 | 4.7 | CCc1cc2c(=O)n(CC(=O)c3ccc(OC)cc3)c(=O)n(Cc3ccc(-c4ccccc4-c4nc(=O)o[nH]4)cc3OC)c2s1 | nan | |||
| 44278118 | 197310 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 587 | 9 | 0 | 8 | 5.9 | CCCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL266480 | 197310 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 587 | 9 | 0 | 8 | 5.9 | CCCCN(C(=O)c1ccc(F)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44277737 | 200771 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 627 | 11 | 0 | 10 | 5.3 | CCOC(=O)CCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29192 | 200771 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 627 | 11 | 0 | 10 | 5.3 | CCOC(=O)CCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44315180 | 202949 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL305956 | 202949 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 621 | 9 | 2 | 8 | 4.9 | Cc1nc2ccc(NC(=O)N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44315059 | 469599 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74144 | 469599 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44315057 | 469710 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL75401 | 469710 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 19802473 | 412142 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 415 | 5 | 1 | 7 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL58156 | 412142 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 415 | 5 | 1 | 7 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccsc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 10101582 | 238134 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 747 | 15 | 2 | 8 | 7.4 | CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL344466 | 238134 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 747 | 15 | 2 | 8 | 7.4 | CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 | 10.1007/s00044-013-0831-x | |||
| 10342301 | 41317 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 3.7 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9979771 | 41317 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 3.7 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125766 | 41317 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 3.7 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125937 | 41317 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 3.7 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9935106 | 137582 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL18287 | 137582 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44338708 | 219979 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.0 | CCCCC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| CHEMBL324629 | 219979 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.0 | CCCCC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| 44277443 | 200466 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.0 | CCCCC(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28918 | 200466 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.0 | CCCCC(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 9935106 | 137582 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL18287 | 137582 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 57380412 | 142771 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1947129 | 142771 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 44303230 | 448632 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL59957 | 448632 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 515 | 10 | 1 | 6 | 5.0 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10349506 | 474909 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97615 | 474909 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 668 | 10 | 1 | 7 | 6.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(Cl)c2)cc1 | 10.1021/jm00043a020 | |||
| 10101582 | 238134 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 747 | 15 | 2 | 8 | 7.4 | CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 | 10.1021/jm00052a006 | |||
| CHEMBL344466 | 238134 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 747 | 15 | 2 | 8 | 7.4 | CCCCCNC(=O)c1ccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c(Cl)c1 | 10.1021/jm00052a006 | |||
| 76333687 | 176210 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 506 | 11 | 1 | 6 | 5.0 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C2(C(=O)OC)CCCC2)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2259779 | 176210 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 506 | 11 | 1 | 6 | 5.0 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C2(C(=O)OC)CCCC2)cc1 | 10.1007/s00044-009-9205-9 | |||
| 15231091 | 194403 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL24861 | 194403 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 44338697 | 219223 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 613 | 11 | 1 | 8 | 6.8 | CCCOC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| CHEMBL322471 | 219223 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 613 | 11 | 1 | 8 | 6.8 | CCCOC(=O)N(Cc1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1021/jm00073a024 | |||
| 44277738 | 200356 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 589 | 7 | 0 | 8 | 6.3 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(C(=O)c4ccccc4)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28816 | 200356 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 589 | 7 | 0 | 8 | 6.3 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(C(=O)c4ccccc4)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 76324571 | 213700 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 378 | 7 | 1 | 8 | 1.9 | CCCCc1nn(C)c(=O)n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2013.10.017 | |||
| CHEMBL3092993 | 213700 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 378 | 7 | 1 | 8 | 1.9 | CCCCc1nn(C)c(=O)n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2013.10.017 | |||
| 9939191 | 199181 | 1 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL279629 | 199181 | 1 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 15231091 | 194403 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL24861 | 194403 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| 10004646 | 40381 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 464 | 9 | 2 | 6 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10095986 | 40381 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 464 | 9 | 2 | 6 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL123568 | 40381 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 464 | 9 | 2 | 6 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL126037 | 40381 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 464 | 9 | 2 | 6 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277901 | 201520 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 10 | 1 | 9 | 4.7 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CCCCO)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29722 | 201520 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 10 | 1 | 9 | 4.7 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CCCCO)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 11764669 | 139107 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL18606 | 139107 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 46910495 | 157990 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058861 | 157990 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 54578725 | 137427 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 403 | 8 | 3 | 7 | 4.0 | CCCCn1ncc(C(=O)O)c1Nc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL1824184 | 137427 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 403 | 8 | 3 | 7 | 4.0 | CCCCn1ncc(C(=O)O)c1Nc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| 44211506 | 120336 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 557 | 10 | 1 | 6 | 5.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL166338 | 120336 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 557 | 10 | 1 | 6 | 5.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44376780 | 119303 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 509 | 10 | 1 | 7 | 4.1 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL163486 | 119303 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 509 | 10 | 1 | 7 | 4.1 | CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10349845 | 25640 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 708 | 10 | 1 | 8 | 7.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL1179731 | 25640 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 708 | 10 | 1 | 8 | 7.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(Cl)sc2Cl)cc1 | 10.1021/jm00043a020 | |||
| 11764669 | 139107 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL18606 | 139107 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.5 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10054753 | 474991 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 629 | 9 | 2 | 7 | 5.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL98140 | 474991 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 629 | 9 | 2 | 7 | 5.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)(C)C)cc1 | 10.1021/jm00043a020 | |||
| 135723840 | 276475 | 0 | None | None | None | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL3787059 | 276475 | 0 | None | None | None | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| 10414470 | 41006 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 524 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9984303 | 41006 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 524 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125542 | 41006 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 524 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125818 | 41006 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 524 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| 127035264 | 273943 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 601 | 11 | 2 | 7 | 7.3 | CCCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736244 | 273943 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 601 | 11 | 2 | 7 | 7.3 | CCCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 183134 | 7963 | 16 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm200409s | |||
| 3939 | 7963 | 16 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm200409s | |||
| CHEMBL7550 | 7963 | 16 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm200409s | |||
| 24755620 | 8610 | 72 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| 2806 | 8610 | 72 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| 3937 | 8610 | 72 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| 5284633 | 8610 | 72 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| 60846 | 8610 | 72 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL1069 | 8610 | 72 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL115622 | 8610 | 72 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL5315276 | 8610 | 72 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| DB00177 | 8610 | 72 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| 10342301 | 41317 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 3.7 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9979771 | 41317 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 3.7 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125766 | 41317 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 3.7 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125937 | 41317 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 3.7 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277547 | 199422 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 589 | 10 | 0 | 9 | 6.2 | CCCCCN(C(=O)c1cccs1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL281453 | 199422 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 589 | 10 | 0 | 9 | 6.2 | CCCCCN(C(=O)c1cccs1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44277463 | 201436 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 584 | 10 | 0 | 9 | 5.5 | CCCCCN(C(=O)c1ccncc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29654 | 201436 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 584 | 10 | 0 | 9 | 5.5 | CCCCCN(C(=O)c1ccncc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44348408 | 232613 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Cl)cc1 | 10.1021/jm00075a033 | |||
| CHEMBL332239 | 232613 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 533 | 11 | 1 | 5 | 7.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Cl)cc1 | 10.1021/jm00075a033 | |||
| 44379086 | 119377 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 543 | 9 | 1 | 6 | 5.4 | CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL164174 | 119377 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 543 | 9 | 1 | 6 | 5.4 | CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 108185 | 3317 | 57 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00043a020 | |||
| 586 | 3317 | 57 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00043a020 | |||
| CHEMBL907 | 3317 | 57 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00043a020 | |||
| 10372723 | 216949 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 724 | 12 | 1 | 7 | 7.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL317368 | 216949 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 724 | 12 | 1 | 7 | 7.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10349029 | 474943 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 628 | 10 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCOC2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97812 | 474943 | 0 | None | None | None | Rabbit | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 628 | 10 | 1 | 8 | 5.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCOC2)cc1 | 10.1021/jm00043a020 | |||
| 145946921 | 332370 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 592 | 11 | 1 | 7 | 5.5 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL4300967 | 332370 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 592 | 11 | 1 | 7 | 5.5 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[n-]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 10298977 | 473297 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 471 | 9 | 1 | 7 | 4.9 | CCCCc1nn(CC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87239 | 473297 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 471 | 9 | 1 | 7 | 4.9 | CCCCc1nn(CC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 131654 | 473370 | 11 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87778 | 473370 | 11 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1nn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 10055096 | 198568 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 656 | 15 | 1 | 7 | 7.3 | CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL274712 | 198568 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 656 | 15 | 1 | 7 | 7.3 | CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 25147556 | 347939 | 0 | None | None | None | Bovine | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 538 | 7 | 1 | 6 | 6.9 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C2=NCCN2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL453934 | 347939 | 0 | None | None | None | Bovine | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 538 | 7 | 1 | 6 | 6.9 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C2=NCCN2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 44377261 | 238620 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 402 | 8 | 1 | 7 | 3.6 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL349389 | 238620 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 402 | 8 | 1 | 7 | 3.6 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10055096 | 198568 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 656 | 15 | 1 | 7 | 7.3 | CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL274712 | 198568 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 656 | 15 | 1 | 7 | 7.3 | CCCCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nn(-c3ccccc3C(F)(F)F)c2=O)cc1 | 10.1021/jm00043a020 | |||
| 44316916 | 214470 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 474 | 12 | 4 | 5 | 4.2 | CCCCc1ncc(CN[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1016/0960-894X(94)00456-P | |||
| 44317214 | 214470 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 474 | 12 | 4 | 5 | 4.2 | CCCCc1ncc(CN[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1016/0960-894X(94)00456-P | |||
| CHEMBL310752 | 214470 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 474 | 12 | 4 | 5 | 4.2 | CCCCc1ncc(CN[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1016/0960-894X(94)00456-P | |||
| CHEMBL79242 | 214470 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 474 | 12 | 4 | 5 | 4.2 | CCCCc1ncc(CN[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1016/0960-894X(94)00456-P | |||
| 44295009 | 370420 | 0 | None | None | None | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL49207 | 370420 | 0 | None | None | None | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44275060 | 199904 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 576 | 7 | 2 | 7 | 6.3 | O=C(O)c1ccccc1-c1ccc(-c2nc3ccccc3c(=O)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL284764 | 199904 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 576 | 7 | 2 | 7 | 6.3 | O=C(O)c1ccccc1-c1ccc(-c2nc3ccccc3c(=O)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10370172 | 104064 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.5 | CCCCc1nnc(SC(C(=O)O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL157690 | 104064 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.5 | CCCCc1nnc(SC(C(=O)O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44277444 | 201078 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 569 | 11 | 0 | 8 | 6.5 | CCCCCN(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29402 | 201078 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 569 | 11 | 0 | 8 | 6.5 | CCCCCN(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44311406 | 213529 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 701 | 13 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)N(c3ccccc3)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL309081 | 213529 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 701 | 13 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)N(c3ccccc3)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44322315 | 473238 | 0 | None | None | None | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 469 | 7 | 1 | 7 | 4.7 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(=O)OC)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL86858 | 473238 | 0 | None | None | None | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 469 | 7 | 1 | 7 | 4.7 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(=O)OC)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 44285177 | 276015 | 0 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 496 | 6 | 1 | 5 | 4.9 | CCCC1=NC(C(F)(F)F)(C(F)(F)F)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL37768 | 276015 | 0 | None | None | None | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 496 | 6 | 1 | 5 | 4.9 | CCCC1=NC(C(F)(F)F)(C(F)(F)F)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 10370172 | 104064 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.5 | CCCCc1nnc(SC(C(=O)O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157690 | 104064 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.5 | CCCCc1nnc(SC(C(=O)O)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 73349424 | 183440 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 495 | 7 | 1 | 4 | 6.3 | CCCc1nc2c(C)cc(C(=O)N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435833 | 183440 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 495 | 7 | 1 | 4 | 6.3 | CCCc1nc2c(C)cc(C(=O)N3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 44311568 | 198472 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 607 | 13 | 2 | 8 | 6.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)OCC(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL273992 | 198472 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 607 | 13 | 2 | 8 | 6.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)OCC(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311636 | 469069 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 549 | 9 | 2 | 9 | 3.8 | CCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL70389 | 469069 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 549 | 9 | 2 | 9 | 3.8 | CCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311569 | 469592 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 625 | 13 | 2 | 7 | 6.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL74113 | 469592 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 625 | 13 | 2 | 7 | 6.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)Cc2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44377086 | 238649 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 546 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL349652 | 238649 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 546 | 11 | 2 | 7 | 4.8 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 44305267 | 468419 | 0 | None | None | None | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 536 | 9 | 1 | 9 | 3.7 | CCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL65503 | 468419 | 0 | None | None | None | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 536 | 9 | 1 | 9 | 3.7 | CCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 19385603 | 199024 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 455 | 9 | 1 | 5 | 5.6 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL278234 | 199024 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 455 | 9 | 1 | 5 | 5.6 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 | 10.1016/0960-894X(95)00185-V | |||
| 1481 | 7955 | 73 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/j.bmc.2010.10.043 | |||
| 3749 | 7955 | 73 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/j.bmc.2010.10.043 | |||
| 6908 | 7955 | 73 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1513 | 7955 | 73 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1016/j.bmc.2010.10.043 | |||
| 44294976 | 317205 | 0 | None | None | None | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 431 | 6 | 1 | 6 | 3.7 | CCOC(=O)/C=C1\CC(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL413098 | 317205 | 0 | None | None | None | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 431 | 6 | 1 | 6 | 3.7 | CCOC(=O)/C=C1\CC(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44459821 | 196730 | 0 | None | None | None | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 412 | 7 | 1 | 4 | 5.2 | CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL26179 | 196730 | 0 | None | None | None | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 412 | 7 | 1 | 4 | 5.2 | CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 11930 | 2105 | 0 | None | None | None | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 10.1016/S0960-894X(01)80517-5 | |||
| 15780052 | 2105 | 0 | None | None | None | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL289472 | 2105 | 0 | None | None | None | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 10.1016/S0960-894X(01)80517-5 | |||
| 44438869 | 293044 | 0 | None | None | None | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 413 | 5 | 1 | 8 | 3.2 | COC(=O)c1cccc2nc(C)n(Cc3ccc(-n4cccc4-c4nnn[nH]4)cc3)c12 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL392118 | 293044 | 0 | None | None | None | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 413 | 5 | 1 | 8 | 3.2 | COC(=O)c1cccc2nc(C)n(Cc3ccc(-n4cccc4-c4nnn[nH]4)cc3)c12 | 10.1016/j.bmcl.2007.02.042 | |||
| 10600595 | 220664 | 29 | None | None | None | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 474 | 9 | 2 | 8 | 4.1 | CCCc1nc(C(C)(C)O)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL326400 | 220664 | 29 | None | None | None | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 474 | 9 | 2 | 8 | 4.1 | CCCc1nc(C(C)(C)O)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 44341946 | 23897 | 12 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 407 | 9 | 2 | 5 | 3.5 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](C)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| 44342142 | 23897 | 12 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 407 | 9 | 2 | 5 | 3.5 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](C)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL112523 | 23897 | 12 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 407 | 9 | 2 | 5 | 3.5 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](C)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL114653 | 23897 | 12 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 407 | 9 | 2 | 5 | 3.5 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](C)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| 54768659 | 137416 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 507 | 8 | 1 | 8 | 4.6 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccccc1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL1823999 | 137416 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 507 | 8 | 1 | 8 | 4.6 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccccc1 | 10.1016/j.ejmech.2011.05.056 | |||
| 10096495 | 43232 | 0 | None | None | None | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 475 | 6 | 1 | 5 | 6.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(C(F)(F)F)c2n1 | 10.1021/jm00100a007 | |||
| CHEMBL129194 | 43232 | 0 | None | None | None | Guinea pig | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 475 | 6 | 1 | 5 | 6.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(C(F)(F)F)c2n1 | 10.1021/jm00100a007 | |||
| 10810628 | 387170 | 0 | None | None | None | Bovine | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL53322 | 387170 | 0 | None | None | None | Bovine | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 44309366 | 469044 | 0 | None | None | None | Bovine | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 294 | 5 | 1 | 3 | 4.4 | CCCCc1nc2ccccc2n1Cc1ccc(O)c(C)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL70239 | 469044 | 0 | None | None | None | Bovine | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 294 | 5 | 1 | 3 | 4.4 | CCCCc1nc2ccccc2n1Cc1ccc(O)c(C)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 10810628 | 387170 | 0 | None | None | None | Bovine | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL53322 | 387170 | 0 | None | None | None | Bovine | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 127035068 | 273819 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 7.7 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735036 | 273819 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 633 | 10 | 2 | 7 | 7.7 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 164611280 | 368303 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 969 | 22 | 11 | 11 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| CHEMBL4854474 | 368303 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 969 | 22 | 11 | 11 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(=O)N1Cc2ccc(O)cc2C[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| 53309272 | 136109 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 449 | 4 | 1 | 6 | 5.3 | CCc1nc2c(C)c(C)c(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801736 | 136109 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 449 | 4 | 1 | 6 | 5.3 | CCc1nc2c(C)c(C)c(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 1315061 | 61905 | 6 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 409 | 7 | 1 | 4 | 3.3 | Cc1ccc(CN(c2ccc(C(=O)NCc3ccccn3)cc2)S(C)(=O)=O)cc1 | 10.1016/j.bmc.2016.07.047 | |||
| CHEMBL1374011 | 61905 | 6 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 409 | 7 | 1 | 4 | 3.3 | Cc1ccc(CN(c2ccc(C(=O)NCc3ccccn3)cc2)S(C)(=O)=O)cc1 | 10.1016/j.bmc.2016.07.047 | |||
| 70682147 | 157995 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 573 | 10 | 2 | 6 | 6.3 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058866 | 157995 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 573 | 10 | 2 | 6 | 6.3 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 10029950 | 103877 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL157524 | 103877 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956750 | 470872 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccc(F)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL85596 | 470872 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccc(F)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44277653 | 201534 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 645 | 11 | 0 | 9 | 5.9 | CCCCCN(C(=O)c1ccc([S+](C)[O-])cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29730 | 201534 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 645 | 11 | 0 | 9 | 5.9 | CCCCCN(C(=O)c1ccc([S+](C)[O-])cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 18004820 | 40341 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 527 | 9 | 2 | 7 | 4.7 | CCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL12333 | 40341 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 527 | 9 | 2 | 7 | 4.7 | CCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 10029950 | 103877 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157524 | 103877 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44377198 | 119320 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 531 | 10 | 1 | 7 | 4.8 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL163628 | 119320 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 531 | 10 | 1 | 7 | 4.8 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10259334 | 474891 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 724 | 13 | 1 | 10 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97500 | 474891 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 724 | 13 | 1 | 10 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1 | 10.1021/jm00043a020 | |||
| 9805344 | 199268 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 483 | 7 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL280290 | 199268 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 483 | 7 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Cl)c(OC(C(=O)O)c2ccccc2)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| 15287886 | 275007 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 483 | 8 | 1 | 5 | 6.3 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2c(Cl)cccc2Cl)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL37566 | 275007 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 483 | 8 | 1 | 5 | 6.3 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2c(Cl)cccc2Cl)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 44286911 | 317313 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 378 | 5 | 1 | 2 | 6.2 | O=C(O)C(Oc1ccc(Cl)cc1C1CCCCC1)c1ccc(Cl)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL41416 | 317313 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 378 | 5 | 1 | 2 | 6.2 | O=C(O)C(Oc1ccc(Cl)cc1C1CCCCC1)c1ccc(Cl)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 44277462 | 38673 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 665 | 11 | 2 | 10 | 5.2 | CCCCN(C(=O)c1ccc(OP(=O)(O)O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL1206522 | 38673 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 665 | 11 | 2 | 10 | 5.2 | CCCCN(C(=O)c1ccc(OP(=O)(O)O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 10077513 | 41148 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 612 | 12 | 0 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(Br)cs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125697 | 41148 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 612 | 12 | 0 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(Br)cs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44294989 | 328205 | 0 | None | None | None | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL418269 | 328205 | 0 | None | None | None | Bovine | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 10073122 | 238504 | 0 | None | None | None | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 464 | 8 | 2 | 6 | 4.8 | CCCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL348149 | 238504 | 0 | None | None | None | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 464 | 8 | 2 | 6 | 4.8 | CCCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10073122 | 238504 | 0 | None | None | None | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 464 | 8 | 2 | 6 | 4.8 | CCCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL348149 | 238504 | 0 | None | None | None | Rabbit | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 464 | 8 | 2 | 6 | 4.8 | CCCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44296533 | 387218 | 0 | None | None | None | Bovine | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 393 | 8 | 3 | 4 | 4.0 | CCCc1cc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL53631 | 387218 | 0 | None | None | None | Bovine | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 393 | 8 | 3 | 4 | 4.0 | CCCc1cc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 44304147 | 200920 | 0 | None | None | None | Rabbit | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 522 | 11 | 0 | 4 | 5.9 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)OC)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL292939 | 200920 | 0 | None | None | None | Rabbit | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 522 | 11 | 0 | 4 | 5.9 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@H](C(=O)OC)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 46910583 | 142596 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945008 | 142596 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 127036297 | 273869 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735492 | 273869 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 127035219 | 273805 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 677 | 12 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3734849 | 273805 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 677 | 12 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 4803452 | 83076 | 3 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 457 | 6 | 1 | 4 | 3.6 | Cc1ccc(C)c(NC(=O)CN(C)C(=O)c2ccc(S(=O)(=O)N3CCCCCC3)cc2)c1 | 10.1016/j.bmc.2016.07.047 | |||
| CHEMBL1474431 | 83076 | 3 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 457 | 6 | 1 | 4 | 3.6 | Cc1ccc(C)c(NC(=O)CN(C)C(=O)c2ccc(S(=O)(=O)N3CCCCCC3)cc2)c1 | 10.1016/j.bmc.2016.07.047 | |||
| 10275744 | 470903 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 451 | 8 | 1 | 7 | 4.3 | CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL85876 | 470903 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 451 | 8 | 1 | 7 | 4.3 | CCCCc1nn(-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44307195 | 202345 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 452 | 4 | 1 | 6 | 3.9 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL303186 | 202345 | 0 | None | None | None | Rabbit | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 452 | 4 | 1 | 6 | 3.9 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44264673 | 469580 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 402 | 7 | 2 | 6 | 4.3 | CCCCc1nc2cnnc(O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL7396 | 469580 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 402 | 7 | 2 | 6 | 4.3 | CCCCc1nc2cnnc(O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 44459662 | 196400 | 0 | None | None | None | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 518 | 8 | 2 | 7 | 5.1 | CCCCc1nc2ccc(C3=NNC(=O)CC3C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| CHEMBL25989 | 196400 | 0 | None | None | None | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 518 | 8 | 2 | 7 | 5.1 | CCCCc1nc2ccc(C3=NNC(=O)CC3C)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| 108185 | 3317 | 57 | None | None | None | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm950450f | |||
| 586 | 3317 | 57 | None | None | None | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm950450f | |||
| CHEMBL907 | 3317 | 57 | None | None | None | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm950450f | |||
| 10027836 | 42806 | 0 | None | None | None | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 437 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL128644 | 42806 | 0 | None | None | None | Guinea pig | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 437 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 | 10.1021/jm00100a007 | |||
| 108185 | 3317 | 57 | None | None | None | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| 586 | 3317 | 57 | None | None | None | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL907 | 3317 | 57 | None | None | None | Bovine | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1016/S0960-894X(01)81143-4 | |||
| 171344487 | 386208 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 321 | 5 | 1 | 3 | 4.4 | CCCCc1c(C(=O)O)c2ccccc2n1C(=O)c1ccccc1 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5271903 | 386208 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 321 | 5 | 1 | 3 | 4.4 | CCCCc1c(C(=O)O)c2ccccc2n1C(=O)c1ccccc1 | 10.1016/j.bmcl.2023.129349 | |||
| 171347662 | 386281 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 455 | 7 | 1 | 5 | 5.0 | O=C(O)c1c(COCc2ccccc2)n(-c2ccc(S(=O)(=O)Cl)cc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5273768 | 386281 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 455 | 7 | 1 | 5 | 5.0 | O=C(O)c1c(COCc2ccccc2)n(-c2ccc(S(=O)(=O)Cl)cc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| 46910494 | 157991 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058862 | 157991 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 10096463 | 102128 | 0 | None | None | None | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 474 | 8 | 1 | 7 | 5.4 | CCCCc1nn2c(-c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155954 | 102128 | 0 | None | None | None | Rabbit | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 474 | 8 | 1 | 7 | 5.4 | CCCCc1nn2c(-c3ccccc3)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10435012 | 235875 | 0 | None | None | None | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 437 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(OC)cc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL338900 | 235875 | 0 | None | None | None | Guinea pig | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 437 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(OC)cc2n1 | 10.1021/jm00100a007 | |||
| 44309242 | 468479 | 0 | None | None | None | Bovine | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 339 | 6 | 1 | 5 | 4.3 | CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL65955 | 468479 | 0 | None | None | None | Bovine | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 339 | 6 | 1 | 5 | 4.3 | CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 44308785 | 469024 | 0 | None | None | None | Bovine | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 420 | 5 | 1 | 3 | 5.0 | CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c(I)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL70134 | 469024 | 0 | None | None | None | Bovine | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 420 | 5 | 1 | 3 | 5.0 | CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c(I)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 14956797 | 473386 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87885 | 473386 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 4.1 | CCCCc1nn(Cc2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 76321525 | 214943 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 552 | 9 | 1 | 7 | 7.2 | CCCc1nn2ccc(-c3nc4ccccc4n3CCC)cc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115243 | 214943 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 552 | 9 | 1 | 7 | 7.2 | CCCc1nn2ccc(-c3nc4ccccc4n3CCC)cc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| 44278151 | 199339 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 619 | 11 | 0 | 9 | 5.4 | CCCCS(=O)(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL280875 | 199339 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 619 | 11 | 0 | 9 | 5.4 | CCCCS(=O)(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 9824568 | 469319 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 441 | 5 | 2 | 7 | 2.8 | Cc1nc(C(=O)O)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/s0960-894x(02)00303-7 | |||
| CHEMBL72053 | 469319 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 441 | 5 | 2 | 7 | 2.8 | Cc1nc(C(=O)O)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/s0960-894x(02)00303-7 | |||
| 127035716 | 273876 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735588 | 273876 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44211673 | 122498 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 678 | 4 | 1 | 8 | 6.6 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCN3C(=O)OCc1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL172376 | 122498 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 678 | 4 | 1 | 8 | 6.6 | CCCc1nc2ccc3cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)CCCCCN3C(=O)OCc1ccccc1 | 10.1016/0960-894X(96)00116-3 | |||
| 14950503 | 199751 | 0 | None | None | None | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 429 | 7 | 1 | 7 | 4.2 | CCc1nc(C)cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)OC | 10.1021/jm00061a016 | |||
| CHEMBL283579 | 199751 | 0 | None | None | None | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 429 | 7 | 1 | 7 | 4.2 | CCc1nc(C)cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)OC | 10.1021/jm00061a016 | |||
| 44305410 | 317852 | 0 | None | None | None | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 556 | 10 | 3 | 8 | 3.5 | CCCc1cc(=O)n(CCNC(=O)NC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL416507 | 317852 | 0 | None | None | None | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 556 | 10 | 3 | 8 | 3.5 | CCCc1cc(=O)n(CCNC(=O)NC2CCCCC2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 73346386 | 183425 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL2435818 | 183425 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10460186 | 235742 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 548 | 12 | 0 | 7 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2sccc2C)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL338123 | 235742 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 548 | 12 | 0 | 7 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2sccc2C)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 70694919 | 158288 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 386 | 8 | 1 | 6 | 3.9 | CCCCc1cnc(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063983 | 158288 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 386 | 8 | 1 | 6 | 3.9 | CCCCc1cnc(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 130762 | 198532 | 5 | None | None | None | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL274447 | 198532 | 5 | None | None | None | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 24827769 | 196238 | 0 | None | None | None | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 425 | 6 | 1 | 7 | 3.7 | CC(C)Cn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL259116 | 196238 | 0 | None | None | None | Rat | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 425 | 6 | 1 | 7 | 3.7 | CC(C)Cn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 54771778 | 137421 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 479 | 8 | 2 | 8 | 5.0 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1Nc1cccc(C)c1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL1824004 | 137421 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 479 | 8 | 2 | 8 | 5.0 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1Nc1cccc(C)c1 | 10.1016/j.ejmech.2011.05.056 | |||
| 14956757 | 139872 | 0 | None | None | None | Rabbit | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| CHEMBL19018 | 139872 | 0 | None | None | None | Rabbit | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| 15287889 | 200593 | 0 | None | None | None | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 9 | 2 | 6 | 4.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C(=O)O)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL290465 | 200593 | 0 | None | None | None | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 9 | 2 | 6 | 4.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C(=O)O)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 19008935 | 317372 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 463 | 6 | 1 | 6 | 5.8 | CCCCc1nc2c(C)cc(C)nc2n1C1CCc2cc(-c3ccccc3-c3nn[nH]n3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL414836 | 317372 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 463 | 6 | 1 | 6 | 5.8 | CCCCc1nc2c(C)cc(C)nc2n1C1CCc2cc(-c3ccccc3-c3nn[nH]n3)ccc21 | 10.1021/jm200409s | |||
| 19010059 | 175920 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 568 | 12 | 3 | 9 | 5.1 | CCCCc1nnc(SCc2ccc(C(=O)O)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237598 | 175920 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 568 | 12 | 3 | 9 | 5.1 | CCCCc1nnc(SCc2ccc(C(=O)O)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 73349223 | 182981 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 713 | 14 | 2 | 8 | 7.3 | CCCCC(=O)Nc1ccc(C)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL2425138 | 182981 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 713 | 14 | 2 | 8 | 7.3 | CCCCC(=O)Nc1ccc(C)c(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1 | 10.1007/s00044-013-0831-x | |||
| 53320976 | 120404 | 0 | None | None | None | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 394 | 5 | 1 | 6 | 4.8 | CCc1cc(Oc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c2ncccc2n1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1668124 | 120404 | 0 | None | None | None | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 394 | 5 | 1 | 6 | 4.8 | CCc1cc(Oc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)c2ncccc2n1 | 10.1016/j.bmc.2010.10.043 | |||
| 10280531 | 327952 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 541 | 10 | 2 | 7 | 5.1 | CCCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL417429 | 327952 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 541 | 10 | 2 | 7 | 5.1 | CCCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 70694919 | 158288 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 386 | 8 | 1 | 6 | 3.9 | CCCCc1cnc(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063983 | 158288 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 386 | 8 | 1 | 6 | 3.9 | CCCCc1cnc(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 10436877 | 101255 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 525 | 11 | 2 | 8 | 5.5 | CCCCc1nnc(SCc2ccc(C(=O)O)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155008 | 101255 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 525 | 11 | 2 | 8 | 5.5 | CCCCc1nnc(SCc2ccc(C(=O)O)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 9914502 | 238430 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 515 | 10 | 1 | 7 | 6.5 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347392 | 238430 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 515 | 10 | 1 | 7 | 6.5 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10327728 | 198415 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL273542 | 198415 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 749 | 9 | 2 | 9 | 6.7 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 44300734 | 201916 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 586 | 9 | 1 | 7 | 6.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CC(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL300154 | 201916 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 586 | 9 | 1 | 7 | 6.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CC(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 11765394 | 237568 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 713 | 14 | 2 | 8 | 7.3 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1C | 10.1021/jm00052a006 | |||
| CHEMBL341986 | 237568 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 713 | 14 | 2 | 8 | 7.3 | CCCCC(=O)Nc1cccc(-n2nc(CCCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4Cl)cc3)c2=O)c1C | 10.1021/jm00052a006 | |||
| 44341946 | 23897 | 12 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 407 | 9 | 2 | 5 | 3.5 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](C)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| 44342142 | 23897 | 12 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 407 | 9 | 2 | 5 | 3.5 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](C)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL112523 | 23897 | 12 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 407 | 9 | 2 | 5 | 3.5 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](C)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL114653 | 23897 | 12 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 407 | 9 | 2 | 5 | 3.5 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](C)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| 171352781 | 386637 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 345 | 4 | 2 | 5 | 2.4 | Cc1ccc(S(=O)(=O)n2c(CO)c(C(=O)O)c3ccccc32)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5282200 | 386637 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 345 | 4 | 2 | 5 | 2.4 | Cc1ccc(S(=O)(=O)n2c(CO)c(C(=O)O)c3ccccc32)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| 71521195 | 177697 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 508 | 6 | 1 | 8 | 3.2 | CCc1nc2ccn(CC(=O)N(C)C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322438 | 177697 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 508 | 6 | 1 | 8 | 3.2 | CCc1nc2ccn(CC(=O)N(C)C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 44298772 | 390577 | 0 | None | None | None | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 452 | 8 | 1 | 7 | 4.3 | CCCCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL55507 | 390577 | 0 | None | None | None | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 452 | 8 | 1 | 7 | 4.3 | CCCCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 44295568 | 201718 | 0 | None | None | None | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 465 | 9 | 1 | 6 | 5.3 | CCCCc1nc2cccc(CN(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL298741 | 201718 | 0 | None | None | None | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 465 | 9 | 1 | 6 | 5.3 | CCCCc1nc2cccc(CN(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44305823 | 327940 | 0 | None | None | None | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 400 | 5 | 1 | 7 | 2.3 | Cn1c(=O)cc(C2CC2)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL417410 | 327940 | 0 | None | None | None | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 400 | 5 | 1 | 7 | 2.3 | Cn1c(=O)cc(C2CC2)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1016/0960-894X(95)00370-9 | |||
| 44295568 | 201718 | 0 | None | None | None | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 465 | 9 | 1 | 6 | 5.3 | CCCCc1nc2cccc(CN(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL298741 | 201718 | 0 | None | None | None | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 465 | 9 | 1 | 6 | 5.3 | CCCCc1nc2cccc(CN(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10459724 | 41842 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 532 | 12 | 1 | 7 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c[nH]c(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL126170 | 41842 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 532 | 12 | 1 | 7 | 4.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c[nH]c(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 70688681 | 158290 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 364 | 8 | 2 | 4 | 4.1 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063985 | 158290 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 364 | 8 | 2 | 4 | 4.1 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 70688681 | 158290 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 364 | 8 | 2 | 4 | 4.1 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063985 | 158290 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 364 | 8 | 2 | 4 | 4.1 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 44306706 | 468136 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 654 | 10 | 1 | 6 | 7.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2NS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL63879 | 468136 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 654 | 10 | 1 | 6 | 7.6 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2NS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44379185 | 120349 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 603 | 13 | 2 | 7 | 5.6 | CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCC(=O)O)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL166428 | 120349 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 603 | 13 | 2 | 7 | 5.6 | CCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCC(=O)O)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 14950506 | 176717 | 0 | None | None | None | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 434 | 6 | 1 | 6 | 5.2 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(-c2ccncc2)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL22945 | 176717 | 0 | None | None | None | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 434 | 6 | 1 | 6 | 5.2 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(-c2ccncc2)c(C)n1 | 10.1021/jm00061a016 | |||
| 15171385 | 331757 | 0 | None | None | None | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 425 | 6 | 1 | 5 | 5.3 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCCC2 | 10.1021/jm00061a016 | |||
| CHEMBL428711 | 331757 | 0 | None | None | None | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 425 | 6 | 1 | 5 | 5.3 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCCC2 | 10.1021/jm00061a016 | |||
| 44305400 | 468005 | 0 | None | None | None | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 478 | 8 | 1 | 7 | 3.9 | CCCc1cc(=O)n(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL62936 | 468005 | 0 | None | None | None | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 478 | 8 | 1 | 7 | 3.9 | CCCc1cc(=O)n(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 76315849 | 176356 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 626 | 13 | 0 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2csc(Br)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2263542 | 176356 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 626 | 13 | 0 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2csc(Br)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 171354030 | 386429 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 359 | 6 | 1 | 5 | 2.9 | CS(=O)(=O)n1c(COCc2ccccc2)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5277518 | 386429 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 359 | 6 | 1 | 5 | 2.9 | CS(=O)(=O)n1c(COCc2ccccc2)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| 9912059 | 368648 | 0 | None | None | None | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL48602 | 368648 | 0 | None | None | None | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44306709 | 202749 | 0 | None | None | None | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 547 | 6 | 1 | 5 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL304655 | 202749 | 0 | None | None | None | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 547 | 6 | 1 | 5 | 5.7 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44298759 | 372977 | 0 | None | None | None | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 438 | 7 | 1 | 7 | 3.9 | CCCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL51689 | 372977 | 0 | None | None | None | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 438 | 7 | 1 | 7 | 3.9 | CCCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 9912059 | 368648 | 0 | None | None | None | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL48602 | 368648 | 0 | None | None | None | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 44348378 | 329162 | 0 | None | None | None | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 4.3 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCC2 | 10.1016/S0960-894X(01)80914-8 | |||
| CHEMBL421094 | 329162 | 0 | None | None | None | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 4.3 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCC2 | 10.1016/S0960-894X(01)80914-8 | |||
| 71521507 | 177684 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 514 | 6 | 1 | 8 | 4.6 | CCc1nc2ccn(Cc3ccncc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322173 | 177684 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 514 | 6 | 1 | 8 | 4.6 | CCc1nc2ccn(Cc3ccncc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 19889599 | 201949 | 0 | None | None | None | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 494 | 10 | 1 | 7 | 5.4 | CCCCc1nc2cccc(CC(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL300451 | 201949 | 0 | None | None | None | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 494 | 10 | 1 | 7 | 5.4 | CCCCc1nc2cccc(CC(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44438902 | 333979 | 0 | None | None | None | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 375 | 5 | 2 | 5 | 3.6 | Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL442251 | 333979 | 0 | None | None | None | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 375 | 5 | 2 | 5 | 3.6 | Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 15654748 | 468895 | 0 | None | None | None | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 3.8 | COCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL69144 | 468895 | 0 | None | None | None | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 3.8 | COCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 9912059 | 368648 | 0 | None | None | None | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL48602 | 368648 | 0 | None | None | None | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| 19889599 | 201949 | 0 | None | None | None | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 494 | 10 | 1 | 7 | 5.4 | CCCCc1nc2cccc(CC(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL300451 | 201949 | 0 | None | None | None | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 494 | 10 | 1 | 7 | 5.4 | CCCCc1nc2cccc(CC(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44309021 | 468940 | 0 | None | None | None | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 436 | 5 | 1 | 3 | 5.7 | CCCCc1nc2ccccc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL69475 | 468940 | 0 | None | None | None | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 436 | 5 | 1 | 3 | 5.7 | CCCCc1nc2ccccc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 44303857 | 200954 | 0 | None | None | None | Rabbit | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL293195 | 200954 | 0 | None | None | None | Rabbit | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O | 10.1016/S0960-894X(01)81007-6 | |||
| 24829094 | 314926 | 0 | None | None | None | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 425 | 8 | 1 | 7 | 4.7 | CCCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc21 | 10.1021/jm7011563 | |||
| CHEMBL409722 | 314926 | 0 | None | None | None | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 425 | 8 | 1 | 7 | 4.7 | CCCCn1nc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccnc21 | 10.1021/jm7011563 | |||
| 2121575 | 122321 | 3 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 381 | 7 | 1 | 4 | 3.5 | CN(Cc1cn(-c2ccccc2)nc1-c1ccc(F)cc1)C(=O)CCC(=O)O | 10.1016/j.bmc.2016.07.047 | |||
| CHEMBL1716544 | 122321 | 3 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 381 | 7 | 1 | 4 | 3.5 | CN(Cc1cn(-c2ccccc2)nc1-c1ccc(F)cc1)C(=O)CCC(=O)O | 10.1016/j.bmc.2016.07.047 | |||
| 24828706 | 314356 | 0 | None | None | None | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 455 | 8 | 1 | 8 | 3.9 | CCCCn1c(=O)c2ccc(OC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL409095 | 314356 | 0 | None | None | None | Rat | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 455 | 8 | 1 | 8 | 3.9 | CCCCn1c(=O)c2ccc(OC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 44274707 | 194771 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 454 | 7 | 1 | 6 | 4.8 | CCCCc1nc2ccc(F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25075 | 194771 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 454 | 7 | 1 | 6 | 4.8 | CCCCc1nc2ccc(F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10482257 | 103974 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2cccc(Cl)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL157620 | 103974 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2cccc(Cl)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44274707 | 194771 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 454 | 7 | 1 | 6 | 4.8 | CCCCc1nc2ccc(F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL25075 | 194771 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 454 | 7 | 1 | 6 | 4.8 | CCCCc1nc2ccc(F)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 11527144 | 346775 | 0 | None | None | None | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| CHEMBL47177 | 346775 | 0 | None | None | None | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| 10482257 | 103974 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2cccc(Cl)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157620 | 103974 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2cccc(Cl)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10028993 | 235712 | 0 | None | None | None | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 465 | 8 | 1 | 6 | 6.0 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC(C)C)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL337955 | 235712 | 0 | None | None | None | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 465 | 8 | 1 | 6 | 6.0 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC(C)C)ccc2n1 | 10.1021/jm00100a007 | |||
| 9984807 | 237258 | 0 | None | None | None | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 505 | 8 | 1 | 6 | 6.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OCC(F)(F)F)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL341210 | 237258 | 0 | None | None | None | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 505 | 8 | 1 | 6 | 6.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OCC(F)(F)F)ccc2n1 | 10.1021/jm00100a007 | |||
| 127029203 | 274830 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 628 | 12 | 3 | 8 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3753458 | 274830 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 628 | 12 | 3 | 8 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 44315057 | 469710 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL75401 | 469710 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 651 | 10 | 2 | 8 | 5.9 | Cc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10076109 | 222320 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 545 | 12 | 0 | 7 | 4.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc[n+]2[O-])n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL330942 | 222320 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 545 | 12 | 0 | 7 | 4.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccc[n+]2[O-])n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 135987615 | 200740 | 0 | None | None | None | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 441 | 6 | 3 | 8 | 4.2 | CNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL291689 | 200740 | 0 | None | None | None | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 441 | 6 | 3 | 8 | 4.2 | CNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 9933755 | 117886 | 0 | None | None | None | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 456 | 9 | 1 | 5 | 5.3 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL16165 | 117886 | 0 | None | None | None | Rabbit | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 456 | 9 | 1 | 5 | 5.3 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 19792151 | 201925 | 0 | None | None | None | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 4.9 | CCCCc1nc2cccc(CC(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL300239 | 201925 | 0 | None | None | None | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 4.9 | CCCCc1nc2cccc(CC(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 3846 | 197151 | 1 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 452 | 7 | 2 | 7 | 4.3 | CCCCc1nc2ccc(O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL26514 | 197151 | 1 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 452 | 7 | 2 | 7 | 4.3 | CCCCc1nc2ccc(O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 14956749 | 473203 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.8 | CCCCc1nn(-c2ccc(CC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL86613 | 473203 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.8 | CCCCc1nn(-c2ccc(CC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44322239 | 473669 | 0 | None | None | None | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 455 | 7 | 2 | 6 | 4.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(=O)O)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL89846 | 473669 | 0 | None | None | None | Guinea pig | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 455 | 7 | 2 | 6 | 4.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(=O)O)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 11527144 | 346775 | 0 | None | None | None | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL47177 | 346775 | 0 | None | None | None | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 44305681 | 202687 | 0 | None | None | None | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 550 | 10 | 1 | 9 | 4.1 | CCCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL304251 | 202687 | 0 | None | None | None | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 550 | 10 | 1 | 9 | 4.1 | CCCCc1cc(=O)n(Cc2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 171351414 | 386937 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 269 | 3 | 2 | 5 | 0.6 | CS(=O)(=O)n1c(CO)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5289070 | 386937 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 269 | 3 | 2 | 5 | 0.6 | CS(=O)(=O)n1c(CO)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| 10739982 | 24383 | 0 | None | None | None | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 404 | 8 | 2 | 4 | 5.0 | C=C(C)c1nc(CCC)n(Cc2ccc(-c3ccccc3C(=O)O)cc2)c1C(=O)O | 10.1021/jm950450f | |||
| CHEMBL115393 | 24383 | 0 | None | None | None | Bovine | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 404 | 8 | 2 | 4 | 5.0 | C=C(C)c1nc(CCC)n(Cc2ccc(-c3ccccc3C(=O)O)cc2)c1C(=O)O | 10.1021/jm950450f | |||
| 10410297 | 330201 | 0 | None | None | None | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 391 | 5 | 1 | 4 | 5.2 | Cc1cc(CCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL423370 | 330201 | 0 | None | None | None | Guinea pig | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 391 | 5 | 1 | 4 | 5.2 | Cc1cc(CCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 44341923 | 219861 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 421 | 10 | 2 | 5 | 4.1 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](CO)C(C)C | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL323911 | 219861 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 421 | 10 | 2 | 5 | 4.1 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](CO)C(C)C | 10.1016/S0960-894X(01)81117-3 | |||
| 10523819 | 385933 | 0 | None | None | None | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 380 | 8 | 3 | 5 | 3.2 | CCCc1nc(CO)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL52601 | 385933 | 0 | None | None | None | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 380 | 8 | 3 | 5 | 3.2 | CCCc1nc(CO)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10523819 | 385933 | 0 | None | None | None | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 380 | 8 | 3 | 5 | 3.2 | CCCc1nc(CO)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL52601 | 385933 | 0 | None | None | None | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 380 | 8 | 3 | 5 | 3.2 | CCCc1nc(CO)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 44274741 | 184053 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 481 | 8 | 1 | 8 | 4.5 | CCCCc1nc2ccc([N+](=O)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24488 | 184053 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 481 | 8 | 1 | 8 | 4.5 | CCCCc1nc2ccc([N+](=O)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 76311804 | 175932 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 507 | 11 | 3 | 8 | 4.7 | CCCCc1nnc(NCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237610 | 175932 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 507 | 11 | 3 | 8 | 4.7 | CCCCc1nnc(NCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44274741 | 184053 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 481 | 8 | 1 | 8 | 4.5 | CCCCc1nc2ccc([N+](=O)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL24488 | 184053 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 481 | 8 | 1 | 8 | 4.5 | CCCCc1nc2ccc([N+](=O)[O-])cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 127035070 | 273911 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 647 | 11 | 2 | 7 | 7.3 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735931 | 273911 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 647 | 11 | 2 | 7 | 7.3 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 10370801 | 101681 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 570 | 12 | 2 | 9 | 4.4 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155554 | 101681 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 570 | 12 | 2 | 9 | 4.4 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10077702 | 104163 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 464 | 10 | 2 | 7 | 5.1 | CCCCc1nnc(NCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157779 | 104163 | 0 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 464 | 10 | 2 | 7 | 5.1 | CCCCc1nnc(NCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 70686381 | 157872 | 0 | None | None | None | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 486 | 7 | 1 | 6 | 5.7 | CCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058368 | 157872 | 0 | None | None | None | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 486 | 7 | 1 | 6 | 5.7 | CCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 10573495 | 24107 | 0 | None | None | None | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 408 | 8 | 3 | 5 | 4.0 | CCCc1nc(C(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL113714 | 24107 | 0 | None | None | None | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 408 | 8 | 3 | 5 | 4.0 | CCCc1nc(C(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10764699 | 233434 | 0 | None | None | None | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 3 | 5 | 4.2 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL333155 | 233434 | 0 | None | None | None | Bovine | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 3 | 5 | 4.2 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10078475 | 232379 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331632 | 232379 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 1610 | 7967 | 67 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0309452 | |||
| 3941 | 7967 | 67 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0309452 | |||
| 3961 | 7967 | 67 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0309452 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm0309452 | |||
| 2541 | 7891 | 68 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| 6907 | 7891 | 68 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| CHEMBL1016 | 7891 | 68 | None | None | None | Rabbit | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| 127034038 | 276525 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 1656 | 46 | 15 | 20 | 2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787702 | 276525 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 1656 | 46 | 15 | 20 | 2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 132603300 | 386369 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 371 | 6 | 1 | 4 | 4.2 | CCCCc1c(C(=O)O)c2ccccc2n1S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5275739 | 386369 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 371 | 6 | 1 | 4 | 4.2 | CCCCc1c(C(=O)O)c2ccccc2n1S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| 1610 | 7967 | 67 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| 3941 | 7967 | 67 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| 3961 | 7967 | 67 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| 19792154 | 372915 | 0 | None | None | None | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cccc(OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51634 | 372915 | 0 | None | None | None | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cccc(OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792154 | 372915 | 0 | None | None | None | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cccc(OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51634 | 372915 | 0 | None | None | None | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cccc(OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792151 | 201925 | 0 | None | None | None | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 4.9 | CCCCc1nc2cccc(CC(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL300239 | 201925 | 0 | None | None | None | Bovine | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 4.9 | CCCCc1nc2cccc(CC(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 46232959 | 450596 | 1 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCc1nc2ccc(C(=O)NC(CC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL601678 | 450596 | 1 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 7.3 | CCCc1nc2ccc(C(=O)NC(CC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| 44274700 | 330138 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 470 | 7 | 1 | 6 | 5.3 | CCCCc1nc2ccc(Cl)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL422932 | 330138 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 470 | 7 | 1 | 6 | 5.3 | CCCCc1nc2ccc(Cl)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44274700 | 330138 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 470 | 7 | 1 | 6 | 5.3 | CCCCc1nc2ccc(Cl)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL422932 | 330138 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 470 | 7 | 1 | 6 | 5.3 | CCCCc1nc2ccc(Cl)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 15171421 | 473201 | 0 | None | None | None | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 425 | 6 | 1 | 5 | 5.3 | CCc1cc(OCc2ccc(-c3c(C)cccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL86604 | 473201 | 0 | None | None | None | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 425 | 6 | 1 | 5 | 5.3 | CCc1cc(OCc2ccc(-c3c(C)cccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 22407453 | 102999 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 415 | 7 | 1 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15671 | 102999 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 415 | 7 | 1 | 5 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 171347856 | 386880 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 295 | 5 | 1 | 4 | 2.5 | CCCCc1c(C(=O)O)c2ccccc2n1S(C)(=O)=O | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5287876 | 386880 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 295 | 5 | 1 | 4 | 2.5 | CCCCc1c(C(=O)O)c2ccccc2n1S(C)(=O)=O | 10.1016/j.bmcl.2023.129349 | |||
| 71521418 | 177706 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 597 | 7 | 1 | 8 | 6.1 | CCc1nc2ccn(Cc3ccccc3OC(F)(F)F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322447 | 177706 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 597 | 7 | 1 | 8 | 6.1 | CCc1nc2ccn(Cc3ccccc3OC(F)(F)F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 76333686 | 176208 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 583 | 14 | 1 | 6 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(S(=O)(=O)NC(F)(F)F)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2259777 | 176208 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 583 | 14 | 1 | 6 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(S(=O)(=O)NC(F)(F)F)cc1 | 10.1007/s00044-009-9205-9 | |||
| 25147556 | 347939 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 538 | 7 | 1 | 6 | 6.9 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C2=NCCN2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| CHEMBL453934 | 347939 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 538 | 7 | 1 | 6 | 6.9 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C2=NCCN2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| 24827900 | 197191 | 0 | None | None | None | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 425 | 6 | 1 | 7 | 3.8 | CCCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL265452 | 197191 | 0 | None | None | None | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 425 | 6 | 1 | 7 | 3.8 | CCCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 71623945 | 273903 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735839 | 273903 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44316861 | 470045 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 345 | 10 | 3 | 5 | 2.1 | CCCCc1ncc(CNCC(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1016/0960-894X(94)00456-P | |||
| CHEMBL78345 | 470045 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 345 | 10 | 3 | 5 | 2.1 | CCCCc1ncc(CNCC(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1016/0960-894X(94)00456-P | |||
| 44274716 | 197194 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 8 | 1 | 8 | 4.0 | CCCCc1nc2ccc(S(C)(=O)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL26548 | 197194 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 8 | 1 | 8 | 4.0 | CCCCc1nc2ccc(S(C)(=O)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 11756787 | 238249 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL345459 | 238249 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10053110 | 176211 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 543 | 12 | 1 | 7 | 5.2 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(N)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2259780 | 176211 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 543 | 12 | 1 | 7 | 5.2 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(N)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10005890 | 233467 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 492 | 9 | 2 | 5 | 4.7 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2ccc(Cl)cc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL333411 | 233467 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 492 | 9 | 2 | 5 | 4.7 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2ccc(Cl)cc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44311775 | 203064 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 582 | 11 | 1 | 7 | 7.3 | CCCc1nc(CC)c(C(=O)OCc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306923 | 203064 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 582 | 11 | 1 | 7 | 7.3 | CCCc1nc(CC)c(C(=O)OCc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311776 | 203065 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 582 | 11 | 1 | 7 | 7.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306924 | 203065 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 582 | 11 | 1 | 7 | 7.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311755 | 203183 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 735 | 18 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OCc2ccccc2OCCC(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL307866 | 203183 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 735 | 18 | 1 | 9 | 8.5 | CCCc1nc(CC)c(C(=O)OCc2ccccc2OCCC(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 44311436 | 469116 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 725 | 15 | 1 | 8 | 8.7 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL70793 | 469116 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 725 | 15 | 1 | 8 | 8.7 | CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/S0960-894X(00)80077-3 | |||
| 10408794 | 158289 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 402 | 8 | 2 | 6 | 3.8 | CCCCc1cnc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063984 | 158289 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 402 | 8 | 2 | 6 | 3.8 | CCCCc1cnc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 44285178 | 200571 | 0 | None | None | None | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 3.6 | CCCC1=NC2(CC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL290180 | 200571 | 0 | None | None | None | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 386 | 6 | 1 | 5 | 3.6 | CCCC1=NC2(CC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 11502835 | 200605 | 0 | None | None | None | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 428 | 6 | 1 | 5 | 4.8 | CCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL290614 | 200605 | 0 | None | None | None | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 428 | 6 | 1 | 5 | 4.8 | CCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 44210864 | 294794 | 0 | None | None | None | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 503 | 8 | 1 | 5 | 4.8 | CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL39352 | 294794 | 0 | None | None | None | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 503 | 8 | 1 | 5 | 4.8 | CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 11756787 | 238249 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345459 | 238249 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 530 | 12 | 2 | 7 | 5.9 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 73346386 | 183425 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435818 | 183425 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 44311739 | 202669 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 563 | 14 | 2 | 7 | 6.2 | CCCCN(Cc1ccccc1)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL304137 | 202669 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 563 | 14 | 2 | 7 | 6.2 | CCCCN(Cc1ccccc1)Cc1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1016/S0960-894X(00)80076-1 | |||
| 44311498 | 202980 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 580 | 10 | 2 | 8 | 4.9 | CCCc1nc(CN2CCN(c3ccc(F)cc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL306216 | 202980 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 580 | 10 | 2 | 8 | 4.9 | CCCc1nc(CN2CCN(c3ccc(F)cc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44379182 | 120913 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 593 | 10 | 1 | 6 | 6.7 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL167662 | 120913 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 593 | 10 | 1 | 6 | 6.7 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10233073 | 474517 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL95198 | 474517 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 638 | 10 | 1 | 8 | 6.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2C)cc1 | 10.1021/jm00043a020 | |||
| 2583 | 8231 | 75 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2009.12.107 | |||
| 592 | 8231 | 75 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2009.12.107 | |||
| 65999 | 8231 | 75 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2009.12.107 | |||
| CHEMBL1017 | 8231 | 75 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2009.12.107 | |||
| DB00966 | 8231 | 75 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1016/j.bmcl.2009.12.107 | |||
| 14956761 | 215656 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 494 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL313025 | 215656 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 494 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 14956778 | 473271 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 431 | 9 | 1 | 7 | 3.9 | CCCCc1nn(CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87057 | 473271 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 431 | 9 | 1 | 7 | 3.9 | CCCCc1nn(CC(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44277936 | 201439 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 573 | 10 | 0 | 9 | 5.7 | CCCCCN(C(=O)c1ccco1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29658 | 201439 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 573 | 10 | 0 | 9 | 5.7 | CCCCCN(C(=O)c1ccco1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 1610 | 7967 | 67 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.07.047 | |||
| 3941 | 7967 | 67 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.07.047 | |||
| 3961 | 7967 | 67 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.07.047 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.07.047 | |||
| 10053126 | 238261 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL345570 | 238261 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 76330043 | 176209 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 527 | 11 | 2 | 6 | 3.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(S(=O)(=O)NC(F)(F)F)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2259778 | 176209 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 527 | 11 | 2 | 6 | 3.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(S(=O)(=O)NC(F)(F)F)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10007312 | 232335 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 534 | 12 | 0 | 6 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CC2CCCCC2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331519 | 232335 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 534 | 12 | 0 | 6 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CC2CCCCC2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10482937 | 331933 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL429058 | 331933 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 10053126 | 238261 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345570 | 238261 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 544 | 12 | 3 | 7 | 5.6 | CCCCc1nnc(SCc2ccccc2C(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44309700 | 203233 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 651 | 13 | 2 | 7 | 7.2 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccc(CCC)cc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL308237 | 203233 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 651 | 13 | 2 | 7 | 7.2 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccc(CCC)cc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| 10078452 | 216911 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL317061 | 216911 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccc(C(F)(F)F)c2)cc1 | 10.1021/jm00043a020 | |||
| 10482937 | 331933 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL429058 | 331933 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 560 | 10 | 1 | 7 | 5.3 | CCCCc1nn(CC(C)(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 10439275 | 332795 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 654 | 10 | 1 | 7 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2C(C)(C)C2(C)C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL432392 | 332795 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 654 | 10 | 1 | 7 | 6.6 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2C(C)(C)C2(C)C)cc1 | 10.1021/jm00043a020 | |||
| 11765177 | 235873 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338888 | 235873 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 685 | 11 | 2 | 9 | 6.4 | CCCCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 15231091 | 194403 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24861 | 194403 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 565 | 10 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10027175 | 39431 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 458 | 9 | 2 | 5 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10049809 | 39431 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 458 | 9 | 2 | 5 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL121874 | 39431 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 458 | 9 | 2 | 5 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331859 | 39431 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 458 | 9 | 2 | 5 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10075811 | 232333 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 534 | 12 | 0 | 7 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331511 | 232333 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 534 | 12 | 0 | 7 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277439 | 200607 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccncc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29063 | 200607 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccncc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 24755620 | 8610 | 72 | None | None | None | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm7011563 | |||
| 2806 | 8610 | 72 | None | None | None | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm7011563 | |||
| 3937 | 8610 | 72 | None | None | None | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm7011563 | |||
| 5284633 | 8610 | 72 | None | None | None | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm7011563 | |||
| 60846 | 8610 | 72 | None | None | None | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm7011563 | |||
| CHEMBL1069 | 8610 | 72 | None | None | None | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm7011563 | |||
| CHEMBL115622 | 8610 | 72 | None | None | None | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm7011563 | |||
| CHEMBL5315276 | 8610 | 72 | None | None | None | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm7011563 | |||
| DB00177 | 8610 | 72 | None | None | None | Rat | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm7011563 | |||
| 10417321 | 39509 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL122157 | 39509 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 701 | 9 | 2 | 9 | 5.8 | CCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 15229605 | 101411 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 463 | 7 | 1 | 5 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15517 | 101411 | 0 | None | None | None | Rabbit | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 463 | 7 | 1 | 5 | 5.8 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)c(Cl)c1 | 10.1016/0960-894X(95)00185-V | |||
| 10408794 | 158289 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 402 | 8 | 2 | 6 | 3.8 | CCCCc1cnc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063984 | 158289 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 402 | 8 | 2 | 6 | 3.8 | CCCCc1cnc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 10343090 | 39427 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 438 | 10 | 1 | 6 | 3.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL121854 | 39427 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 438 | 10 | 1 | 6 | 3.8 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 127035246 | 273841 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.2 | CCOc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735290 | 273841 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.2 | CCOc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 53309404 | 136114 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 491 | 6 | 1 | 6 | 6.4 | Cc1cc(CC(C)C)nc2c1nc(C(C)C)n2[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801741 | 136114 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 491 | 6 | 1 | 6 | 6.4 | Cc1cc(CC(C)C)nc2c1nc(C(C)C)n2[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 9853391 | 235722 | 1 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338027 | 235722 | 1 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 729 | 11 | 2 | 9 | 6.6 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 14956753 | 216718 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 527 | 9 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL315776 | 216718 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 527 | 9 | 1 | 7 | 5.9 | CCCCc1nn(-c2ccccc2-c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44379270 | 119655 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 580 | 9 | 1 | 7 | 5.2 | CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL164395 | 119655 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 580 | 9 | 1 | 7 | 5.2 | CCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10078475 | 232379 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL331632 | 232379 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 46910493 | 157993 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 615 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058864 | 157993 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 615 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 10078475 | 232379 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| CHEMBL331632 | 232379 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1021/jm00019a004 | |||
| 10078475 | 232379 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| CHEMBL331632 | 232379 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 705 | 9 | 2 | 9 | 6.6 | CCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)cc1F | 10.1007/s00044-011-9815-x | |||
| 4673492 | 8951 | 9 | None | None | None | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1016/j.bmc.2010.10.043 | |||
| 8324 | 8951 | 9 | None | None | None | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL159096 | 8951 | 9 | None | None | None | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1016/j.bmc.2010.10.043 | |||
| 19008869 | 473381 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL87842 | 473381 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 10349791 | 221075 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C(F)(F)F)cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL328176 | 221075 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 702 | 10 | 1 | 7 | 7.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(C(F)(F)F)cc2)cc1 | 10.1021/jm00043a020 | |||
| 44315060 | 203106 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL307290 | 203106 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 44338833 | 23484 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 537 | 9 | 2 | 8 | 5.4 | CCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL110265 | 23484 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 537 | 9 | 2 | 8 | 5.4 | CCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 44277593 | 199615 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 661 | 9 | 0 | 10 | 5.9 | COC(=O)c1ccc(CN(C(=O)c2ccccc2)c2ccc3ncn(Cc4ccc(-c5ccccc5-c5nnnn5C)cc4)c(=O)c3c2)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL282778 | 199615 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 661 | 9 | 0 | 10 | 5.9 | COC(=O)c1ccc(CN(C(=O)c2ccccc2)c2ccc3ncn(Cc4ccc(-c5ccccc5-c5nnnn5C)cc4)c(=O)c3c2)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 127029202 | 274732 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 598 | 11 | 3 | 7 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752680 | 274732 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 598 | 11 | 3 | 7 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 73357016 | 183432 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 503 | 8 | 2 | 4 | 7.0 | CCCc1nc2c(C)cc(NC(=O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435825 | 183432 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 503 | 8 | 2 | 4 | 7.0 | CCCc1nc2c(C)cc(NC(=O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 19939495 | 474694 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL96314 | 474694 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 728 | 12 | 1 | 7 | 8.0 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 10461595 | 474966 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 624 | 10 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97964 | 474966 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 624 | 10 | 1 | 8 | 5.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccoc2)cc1 | 10.1021/jm00043a020 | |||
| 44211677 | 258519 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 614 | 4 | 2 | 7 | 6.6 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCCC(=O)NS2(=O)=O | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL368149 | 258519 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 614 | 4 | 2 | 7 | 6.6 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCCC(=O)NS2(=O)=O | 10.1016/0960-894X(96)00116-3 | |||
| 11757471 | 104293 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2cccc(C(=O)OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL157878 | 104293 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2cccc(C(=O)OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10414778 | 330176 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL423233 | 330176 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44311609 | 202864 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 701 | 13 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)N(c3ccccc3)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL305369 | 202864 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 701 | 13 | 1 | 8 | 8.6 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)N(c3ccccc3)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311638 | 202975 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 613 | 18 | 1 | 8 | 6.7 | CCCCN(CCCC)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL306186 | 202975 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 613 | 18 | 1 | 8 | 6.7 | CCCCN(CCCC)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 132562 | 199875 | 5 | None | None | None | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL284536 | 199875 | 5 | None | None | None | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/j.bmc.2010.10.043 | |||
| 10166561 | 24365 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 562 | 9 | 2 | 8 | 5.4 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CO)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
| CHEMBL11528 | 24365 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 562 | 9 | 2 | 8 | 5.4 | CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CO)c1)C(=O)CCCC2 | 10.1039/C4MD00499J | |||
| 10475382 | 158284 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 388 | 8 | 2 | 6 | 3.6 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063979 | 158284 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 388 | 8 | 2 | 6 | 3.6 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 11757471 | 104293 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2cccc(C(=O)OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157878 | 104293 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.7 | CCCCc1nnc(SCc2cccc(C(=O)OC)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10100625 | 104729 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 474 | 8 | 1 | 7 | 5.4 | CCCCc1nn2cc(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL158257 | 104729 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 474 | 8 | 1 | 7 | 5.4 | CCCCc1nn2cc(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10414778 | 330176 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL423233 | 330176 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccccc2Cl)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44275076 | 194232 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 546 | 8 | 1 | 6 | 7.0 | CCCCc1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24764 | 194232 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 546 | 8 | 1 | 6 | 7.0 | CCCCc1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10765381 | 23877 | 0 | None | None | None | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 436 | 9 | 3 | 5 | 4.6 | CCCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL112414 | 23877 | 0 | None | None | None | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 436 | 9 | 3 | 5 | 4.6 | CCCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 1610 | 7967 | 67 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 3941 | 7967 | 67 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 3961 | 7967 | 67 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 9896877 | 123003 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 748 | 6 | 1 | 8 | 8.3 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)N(C(=O)OCc1ccccc1)CCCCCCCC(=O)NS2(=O)=O | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL174080 | 123003 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 748 | 6 | 1 | 8 | 8.3 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)N(C(=O)OCc1ccccc1)CCCCCCCC(=O)NS2(=O)=O | 10.1016/0960-894X(96)00116-3 | |||
| 14950497 | 176680 | 0 | None | None | None | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 399 | 6 | 1 | 6 | 4.3 | CC(=O)c1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1021/jm00061a016 | |||
| CHEMBL22908 | 176680 | 0 | None | None | None | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 399 | 6 | 1 | 6 | 4.3 | CC(=O)c1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1021/jm00061a016 | |||
| 21840324 | 24448 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 501 | 11 | 2 | 5 | 4.9 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(Cc1ccc(F)cc1)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL115783 | 24448 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 501 | 11 | 2 | 5 | 4.9 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(Cc1ccc(F)cc1)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| 44270306 | 105407 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 457 | 8 | 1 | 5 | 6.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)C)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15882 | 105407 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 457 | 8 | 1 | 5 | 6.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)C)c1 | 10.1016/0960-894X(95)00185-V | |||
| 10475382 | 158284 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 388 | 8 | 2 | 6 | 3.6 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063979 | 158284 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 388 | 8 | 2 | 6 | 3.6 | CCCCc1cnc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 57380415 | 142594 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 577 | 11 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945006 | 142594 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 577 | 11 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 127026336 | 274679 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 658 | 13 | 3 | 9 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752160 | 274679 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 658 | 13 | 3 | 9 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 57380416 | 142595 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945007 | 142595 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 10029332 | 100162 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 510 | 12 | 2 | 8 | 4.7 | CCCCc1nnc(SC(CC)C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL154083 | 100162 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 510 | 12 | 2 | 8 | 4.7 | CCCCc1nnc(SC(CC)C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 1610 | 7967 | 67 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81144-6 | |||
| 3941 | 7967 | 67 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81144-6 | |||
| 3961 | 7967 | 67 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81144-6 | |||
| 44285371 | 277974 | 0 | None | None | None | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 512 | 8 | 1 | 5 | 6.0 | CCCC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL38161 | 277974 | 0 | None | None | None | Rat | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 512 | 8 | 1 | 5 | 6.0 | CCCC1=NC(c2ccccc2)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 10029332 | 100162 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 510 | 12 | 2 | 8 | 4.7 | CCCCc1nnc(SC(CC)C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154083 | 100162 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 510 | 12 | 2 | 8 | 4.7 | CCCCc1nnc(SC(CC)C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 14950495 | 199505 | 0 | None | None | None | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 357 | 5 | 1 | 5 | 4.1 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL281999 | 199505 | 0 | None | None | None | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 357 | 5 | 1 | 5 | 4.1 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)n1 | 10.1021/jm00061a016 | |||
| 15654751 | 468904 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 470 | 8 | 2 | 7 | 4.9 | CCSCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL69236 | 468904 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 470 | 8 | 2 | 7 | 4.9 | CCSCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 24755620 | 8610 | 72 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| 2806 | 8610 | 72 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| 3937 | 8610 | 72 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| 5284633 | 8610 | 72 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| 60846 | 8610 | 72 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL1069 | 8610 | 72 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL115622 | 8610 | 72 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL5315276 | 8610 | 72 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| DB00177 | 8610 | 72 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81117-3 | |||
| 11764788 | 201001 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL293501 | 201001 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10459992 | 233285 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 542 | 13 | 0 | 6 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2ccccc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL333058 | 233285 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 542 | 13 | 0 | 6 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCc2ccccc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 127034901 | 273916 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 670 | 12 | 2 | 9 | 5.5 | CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736037 | 273916 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 670 | 12 | 2 | 9 | 5.5 | CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 10029368 | 238556 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 511 | 11 | 1 | 8 | 5.8 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL348606 | 238556 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 511 | 11 | 1 | 8 | 5.8 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 6918269 | 198737 | 11 | None | None | None | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL275875 | 198737 | 11 | None | None | None | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 132562 | 199875 | 5 | None | None | None | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL284536 | 199875 | 5 | None | None | None | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 132562 | 199875 | 5 | None | None | None | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00061a016 | |||
| CHEMBL284536 | 199875 | 5 | None | None | None | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 407 | 6 | 1 | 5 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00061a016 | |||
| 9869504 | 474899 | 3 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 474 | 10 | 2 | 5 | 5.9 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c2ccccc12 | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL97533 | 474899 | 3 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 474 | 10 | 2 | 5 | 5.9 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)c2ccccc12 | 10.1016/S0960-894X(01)81116-1 | |||
| 11764788 | 201001 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL293501 | 201001 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 645 | 11 | 1 | 9 | 5.8 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 171348584 | 386717 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 295 | 3 | 2 | 4 | 2.5 | O=C(O)c1c(CO)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5283862 | 386717 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 295 | 3 | 2 | 4 | 2.5 | O=C(O)c1c(CO)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| 76329880 | 175906 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 448 | 9 | 2 | 8 | 3.8 | CCCCc1nnc(SC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237584 | 175906 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 448 | 9 | 2 | 8 | 3.8 | CCCCc1nnc(SC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 135464357 | 200710 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 440 | 6 | 2 | 7 | 4.8 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL291502 | 200710 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 440 | 6 | 2 | 7 | 4.8 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 10076683 | 103552 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 405 | 8 | 1 | 7 | 4.2 | CCCCc1nnc(SC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157203 | 103552 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 405 | 8 | 1 | 7 | 4.2 | CCCCc1nnc(SC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 9980879 | 235630 | 0 | None | None | None | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.3 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(C)c2n1 | 10.1021/jm00100a007 | |||
| CHEMBL337446 | 235630 | 0 | None | None | None | Guinea pig | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.3 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(C)c2n1 | 10.1021/jm00100a007 | |||
| 44294703 | 375240 | 0 | None | None | None | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 443 | 7 | 1 | 5 | 4.9 | CCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(C)=O)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL52046 | 375240 | 0 | None | None | None | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 443 | 7 | 1 | 5 | 4.9 | CCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(C)=O)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44348345 | 222310 | 0 | None | None | None | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 417 | 6 | 1 | 6 | 3.3 | CCOC(=O)/C=C1/C(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80914-8 | |||
| CHEMBL330866 | 222310 | 0 | None | None | None | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 417 | 6 | 1 | 6 | 3.3 | CCOC(=O)/C=C1/C(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80914-8 | |||
| 19889589 | 369215 | 0 | None | None | None | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL48692 | 369215 | 0 | None | None | None | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10364310 | 42749 | 0 | None | None | None | Guinea pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 411 | 8 | 1 | 3 | 6.5 | CCCCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL128332 | 42749 | 0 | None | None | None | Guinea pig | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 411 | 8 | 1 | 3 | 6.5 | CCCCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 19889589 | 369215 | 0 | None | None | None | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL48692 | 369215 | 0 | None | None | None | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 442 | 7 | 1 | 5 | 5.9 | CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 14962909 | 201845 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299597 | 201845 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10346400 | 102156 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2cccc(C)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL155984 | 102156 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2cccc(C)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44306613 | 468701 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 485 | 10 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1Oc1ccccc1C(=O)O | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL67616 | 468701 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 485 | 10 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1Oc1ccccc1C(=O)O | 10.1016/S0960-894X(01)81148-3 | |||
| 3839 | 8193 | 57 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1021/jm0204237 | |||
| 60919 | 8193 | 57 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1021/jm0204237 | |||
| 6898 | 8193 | 57 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1021/jm0204237 | |||
| CHEMBL432162 | 8193 | 57 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1021/jm0204237 | |||
| DB01349 | 8193 | 57 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1021/jm0204237 | |||
| 10346400 | 102156 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2cccc(C)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155984 | 102156 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2cccc(C)c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44438865 | 184168 | 0 | None | None | None | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 441 | 7 | 1 | 8 | 3.8 | CCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL245644 | 184168 | 0 | None | None | None | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 441 | 7 | 1 | 8 | 3.8 | CCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 44297201 | 202095 | 0 | None | None | None | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 617 | 8 | 1 | 9 | 6.2 | CCCCc1nc2ccc([C@@H]3C[C@H]4C5CCC(C)(C)N5O[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL301547 | 202095 | 0 | None | None | None | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 617 | 8 | 1 | 9 | 6.2 | CCCCc1nc2ccc([C@@H]3C[C@H]4C5CCC(C)(C)N5O[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 44376747 | 238776 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 510 | 11 | 2 | 7 | 3.9 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL350851 | 238776 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 510 | 11 | 2 | 7 | 3.9 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 15654755 | 213530 | 0 | None | None | None | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 426 | 6 | 2 | 7 | 3.6 | COc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL309084 | 213530 | 0 | None | None | None | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 426 | 6 | 2 | 7 | 3.6 | COc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 171353965 | 386383 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 385 | 6 | 1 | 4 | 4.7 | O=C(O)c1c(COCc2ccccc2)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5276125 | 386383 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 385 | 6 | 1 | 4 | 4.7 | O=C(O)c1c(COCc2ccccc2)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| 127029201 | 274663 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 644 | 12 | 3 | 9 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3751994 | 274663 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 644 | 12 | 3 | 9 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 44294649 | 372247 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 4.1 | CCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL51001 | 372247 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 4.1 | CCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 11755164 | 238439 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.4 | CCCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL347513 | 238439 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.4 | CCCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 11756222 | 102610 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 514 | 12 | 2 | 6 | 6.0 | CCCSc1nnc(CCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156396 | 102610 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 514 | 12 | 2 | 6 | 6.0 | CCCSc1nnc(CCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 14962909 | 201845 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299597 | 201845 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10525501 | 201919 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 408 | 8 | 3 | 5 | 3.6 | CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL300186 | 201919 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 408 | 8 | 3 | 5 | 3.6 | CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10525501 | 201919 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 408 | 8 | 3 | 5 | 3.6 | CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL300186 | 201919 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 408 | 8 | 3 | 5 | 3.6 | CCCc1nc(C(=O)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 44308996 | 203023 | 0 | None | None | None | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 348 | 5 | 1 | 3 | 5.4 | CCCCc1nc2ccccc2n1Cc1cc(Cl)c(O)c(Cl)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL306486 | 203023 | 0 | None | None | None | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 348 | 5 | 1 | 3 | 5.4 | CCCCc1nc2ccccc2n1Cc1cc(Cl)c(O)c(Cl)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 15654746 | 468704 | 0 | None | None | None | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 452 | 7 | 2 | 6 | 4.8 | CC(C)Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL67636 | 468704 | 0 | None | None | None | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 452 | 7 | 2 | 6 | 4.8 | CC(C)Cc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 15287888 | 200408 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 421 | 8 | 1 | 5 | 5.2 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)C2CCCCC2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL288618 | 200408 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 421 | 8 | 1 | 5 | 5.2 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)C2CCCCC2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 57380413 | 142772 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1947130 | 142772 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 15355268 | 201798 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2ccc(C)c(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299340 | 201798 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2ccc(C)c(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44274746 | 199864 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 591 | 7 | 3 | 8 | 5.9 | Nc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL284455 | 199864 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 591 | 7 | 3 | 8 | 5.9 | Nc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| 14956751 | 473278 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87073 | 473278 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccc(C(=O)OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 10483230 | 100099 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 574 | 11 | 2 | 8 | 5.1 | CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154027 | 100099 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 574 | 11 | 2 | 8 | 5.1 | CCCCc1nnc([S+]([O-])Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44438885 | 181770 | 0 | None | None | None | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 417 | 8 | 2 | 5 | 4.6 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL239378 | 181770 | 0 | None | None | None | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 417 | 8 | 2 | 5 | 4.6 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 44315060 | 203106 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL307290 | 203106 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 665 | 10 | 2 | 9 | 4.9 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CC)nc3ccc(NC(=O)N4CCOCC4)cc3c2=O)c(F)c1 | 10.1016/0960-894X(94)85036-4 | |||
| 44295069 | 201278 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCC1(CCC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL295369 | 201278 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCC1(CCC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 10028212 | 102164 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 482 | 11 | 2 | 8 | 3.9 | CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL155992 | 102164 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 482 | 11 | 2 | 8 | 3.9 | CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44307174 | 200888 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 366 | 6 | 1 | 6 | 4.0 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc([N+](=O)[O-])c1O | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL292739 | 200888 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 366 | 6 | 1 | 6 | 4.0 | C=CCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc([N+](=O)[O-])c1O | 10.1016/S0960-894X(01)81148-3 | |||
| 1610 | 7967 | 67 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80366-2 | |||
| 3941 | 7967 | 67 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80366-2 | |||
| 3961 | 7967 | 67 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80366-2 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80366-2 | |||
| 10028212 | 102164 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 482 | 11 | 2 | 8 | 3.9 | CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155992 | 102164 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 482 | 11 | 2 | 8 | 3.9 | CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 19792124 | 371476 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 7 | 1 | 5 | 5.6 | CCCCc1nc2cccc(C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL49980 | 371476 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 7 | 1 | 5 | 5.6 | CCCCc1nc2cccc(C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 1610 | 7967 | 67 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80377-2 | |||
| 3941 | 7967 | 67 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80377-2 | |||
| 3961 | 7967 | 67 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80377-2 | |||
| 19792124 | 371476 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 7 | 1 | 5 | 5.6 | CCCCc1nc2cccc(C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL49980 | 371476 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 7 | 1 | 5 | 5.6 | CCCCc1nc2cccc(C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44352233 | 42793 | 0 | None | None | None | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 383 | 6 | 1 | 6 | 4.0 | CCCc1cn2nccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL128590 | 42793 | 0 | None | None | None | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 383 | 6 | 1 | 6 | 4.0 | CCCc1cn2nccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| 44308795 | 468883 | 0 | None | None | None | Bovine | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 532 | 5 | 1 | 3 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(I)c(O)c1I | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL69025 | 468883 | 0 | None | None | None | Bovine | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 532 | 5 | 1 | 3 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(I)c(O)c1I | 10.1016/S0960-894X(01)81149-5 | |||
| 71652856 | 180001 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 545 | 11 | 2 | 3 | 6.9 | CCCCc1c[n+](Cc2ccc(-c3ccccc3C(=O)O)cc2)cn1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2365829 | 180001 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 545 | 11 | 2 | 3 | 6.9 | CCCCc1c[n+](Cc2ccc(-c3ccccc3C(=O)O)cc2)cn1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 44210830 | 120279 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 461 | 6 | 1 | 6 | 5.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(C(=O)O)(c1ccccc1)S2 | 10.1016/S0960-894X(01)80193-1 | |||
| CHEMBL165850 | 120279 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 461 | 6 | 1 | 6 | 5.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(C(=O)O)(c1ccccc1)S2 | 10.1016/S0960-894X(01)80193-1 | |||
| 14950496 | 175972 | 0 | None | None | None | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 483 | 5 | 1 | 5 | 4.7 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(I)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL22391 | 175972 | 0 | None | None | None | Guinea pig | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 483 | 5 | 1 | 5 | 4.7 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(I)c(C)n1 | 10.1021/jm00061a016 | |||
| 44305634 | 202454 | 0 | None | None | None | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 428 | 8 | 1 | 7 | 3.0 | C=CCn1c(=O)cc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL303822 | 202454 | 0 | None | None | None | Bovine | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 428 | 8 | 1 | 7 | 3.0 | C=CCn1c(=O)cc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1=O | 10.1016/0960-894X(95)00370-9 | |||
| 11757112 | 222427 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 542 | 12 | 0 | 6 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331081 | 222427 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 542 | 12 | 0 | 6 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 15355268 | 201798 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2ccc(C)c(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299340 | 201798 | 0 | None | None | None | Bovine | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 466 | 8 | 2 | 6 | 5.3 | CCCCc1nc2ccc(C)c(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 14962904 | 385641 | 0 | None | None | None | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnnn2C)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52265 | 385641 | 0 | None | None | None | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnnn2C)cc1 | 10.1007/s00044-009-9182-z | |||
| 14962904 | 385641 | 0 | None | None | None | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnnn2C)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52265 | 385641 | 0 | None | None | None | Bovine | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnnn2C)cc1 | 10.1007/s00044-009-9182-z | |||
| 127034919 | 273952 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 599 | 10 | 2 | 7 | 6.6 | CCCc1nc2c(C)cc(C(=O)NC(C)C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736310 | 273952 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 599 | 10 | 2 | 7 | 6.6 | CCCc1nc2c(C)cc(C(=O)NC(C)C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 127034739 | 273818 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 585 | 10 | 2 | 6 | 7.3 | CCCc1nc2c(C)cc(C(=S)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734989 | 273818 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 585 | 10 | 2 | 6 | 7.3 | CCCc1nc2c(C)cc(C(=S)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 127026058 | 274651 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 600 | 10 | 3 | 8 | 6.0 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3751899 | 274651 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 600 | 10 | 3 | 8 | 6.0 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 71521298 | 177699 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 481 | 6 | 2 | 8 | 3.2 | CCc1nc2ccn(CC(=O)O)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322440 | 177699 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 481 | 6 | 2 | 8 | 3.2 | CCc1nc2ccn(CC(=O)O)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 76329882 | 175911 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 538 | 12 | 2 | 8 | 5.4 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237589 | 175911 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 538 | 12 | 2 | 8 | 5.4 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44377171 | 238884 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 485 | 6 | 1 | 8 | 5.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(c1ccccc1)(c1nn[nH]n1)S2 | 10.1016/S0960-894X(01)80193-1 | |||
| CHEMBL352042 | 238884 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 485 | 6 | 1 | 8 | 5.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)SC(c1ccccc1)(c1nn[nH]n1)S2 | 10.1016/S0960-894X(01)80193-1 | |||
| 10323527 | 101286 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 495 | 11 | 1 | 7 | 5.9 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155035 | 101286 | 0 | None | None | None | Rabbit | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 495 | 11 | 1 | 7 | 5.9 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10098291 | 39451 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 3.6 | CCCCc1ncc(/C=C2/C(=O)N(CO)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL121990 | 39451 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 523 | 10 | 1 | 9 | 3.6 | CCCCc1ncc(/C=C2/C(=O)N(CO)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 76322687 | 175904 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 535 | 10 | 2 | 8 | 4.4 | CCCCc1nnc(C(=O)N(C)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237582 | 175904 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 535 | 10 | 2 | 8 | 4.4 | CCCCc1nnc(C(=O)N(C)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10323388 | 102550 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 492 | 9 | 1 | 7 | 4.8 | CCCCc1nnc(C(=O)N(C)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156352 | 102550 | 0 | None | None | None | Rabbit | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 492 | 9 | 1 | 7 | 4.8 | CCCCc1nnc(C(=O)N(C)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 1610 | 7967 | 67 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| 3941 | 7967 | 67 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| 3961 | 7967 | 67 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.9b00179 | |||
| 76322688 | 175908 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 530 | 11 | 2 | 8 | 5.8 | CCCCc1nnc(SCC2CCCCC2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237586 | 175908 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 530 | 11 | 2 | 8 | 5.8 | CCCCc1nnc(SCC2CCCCC2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 19010047 | 175923 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 554 | 12 | 3 | 9 | 4.9 | CCCCc1nnc(SCc2ccccc2CO)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237601 | 175923 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 554 | 12 | 3 | 9 | 4.9 | CCCCc1nnc(SCc2ccccc2CO)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 15224461 | 43277 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 467 | 8 | 2 | 7 | 4.7 | CCCCc1nc2c(C)cnc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL129447 | 43277 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 467 | 8 | 2 | 7 | 4.7 | CCCCc1nc2c(C)cnc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| 9986992 | 104739 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 511 | 11 | 2 | 8 | 5.3 | CCCCc1nnc(SCc2ccccc2CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL158267 | 104739 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 511 | 11 | 2 | 8 | 5.3 | CCCCc1nnc(SCc2ccccc2CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10032191 | 238315 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 487 | 10 | 1 | 7 | 6.2 | CCCCc1nnc(SCC2CCCCC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL346145 | 238315 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 487 | 10 | 1 | 7 | 6.2 | CCCCc1nnc(SCC2CCCCC2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44287123 | 200361 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 465 | 8 | 1 | 5 | 6.1 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2cccc3ccccc23)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL288222 | 200361 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 465 | 8 | 1 | 5 | 6.1 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2cccc3ccccc23)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 127029204 | 274717 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 628 | 12 | 3 | 8 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752530 | 274717 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 628 | 12 | 3 | 8 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 71521503 | 177708 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 527 | 6 | 1 | 7 | 5.5 | CCc1nc2ccn(Cc3cccc(C)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322449 | 177708 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 527 | 6 | 1 | 7 | 5.5 | CCc1nc2ccn(Cc3cccc(C)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 135723833 | 408712 | 3 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 442 | 6 | 2 | 8 | 4.2 | COc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL57783 | 408712 | 3 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 442 | 6 | 2 | 8 | 4.2 | COc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 10811315 | 219813 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 406 | 8 | 2 | 4 | 5.1 | CCCc1nc(C(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL323819 | 219813 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 406 | 8 | 2 | 4 | 5.1 | CCCc1nc(C(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10412363 | 44724 | 0 | None | None | None | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 432 | 6 | 1 | 6 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C#N)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL131050 | 44724 | 0 | None | None | None | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 432 | 6 | 1 | 6 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C#N)ccc2n1 | 10.1021/jm00100a007 | |||
| 121879 | 4554 | 28 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 509 | 7 | 3 | 6 | 3.6 | O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2 | 10.1021/jm0309452 | |||
| 5868 | 4554 | 28 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 509 | 7 | 3 | 6 | 3.6 | O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2 | 10.1021/jm0309452 | |||
| CHEMBL308716 | 4554 | 28 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 509 | 7 | 3 | 6 | 3.6 | O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2 | 10.1021/jm0309452 | |||
| 127028617 | 274967 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 536 | 10 | 3 | 7 | 4.9 | CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)Nc4nnn[nH]4)cc3)c2c1 | 10.1039/C5MD00169B | |||
| CHEMBL3754661 | 274967 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 536 | 10 | 3 | 7 | 4.9 | CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)Nc4nnn[nH]4)cc3)c2c1 | 10.1039/C5MD00169B | |||
| 127034740 | 273929 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 585 | 10 | 2 | 6 | 7.3 | CCCc1nc2c(C)cc(C(=S)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736166 | 273929 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 585 | 10 | 2 | 6 | 7.3 | CCCc1nc2c(C)cc(C(=S)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 127035544 | 273807 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 721 | 14 | 2 | 9 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3734870 | 273807 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 721 | 14 | 2 | 9 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 10692816 | 24235 | 1 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 408 | 7 | 3 | 5 | 3.8 | CCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL114527 | 24235 | 1 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 408 | 7 | 3 | 5 | 3.8 | CCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 70688504 | 157994 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 573 | 10 | 2 | 6 | 6.3 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058865 | 157994 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 573 | 10 | 2 | 6 | 6.3 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 71521301 | 177702 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 531 | 6 | 1 | 7 | 5.3 | CCc1nc2ccn(Cc3ccccc3F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322443 | 177702 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 531 | 6 | 1 | 7 | 5.3 | CCc1nc2ccn(Cc3ccccc3F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 76308180 | 175930 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 508 | 11 | 2 | 8 | 4.7 | CCCCc1nnc(OCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237608 | 175930 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 508 | 11 | 2 | 8 | 4.7 | CCCCc1nnc(OCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44459780 | 182955 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2cc(C)ccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL24218 | 182955 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2cc(C)ccc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 44459634 | 196494 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2cccc(C)c2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL26048 | 196494 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2cccc(C)c2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 10069271 | 77970 | 0 | None | None | None | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 395 | 4 | 1 | 5 | 5.5 | Cc1cc(Sc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL142860 | 77970 | 0 | None | None | None | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 395 | 4 | 1 | 5 | 5.5 | Cc1cc(Sc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/j.bmc.2010.10.043 | |||
| 10389770 | 238375 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 465 | 10 | 1 | 7 | 5.1 | CCCCc1nnc(OCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL346773 | 238375 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 465 | 10 | 1 | 7 | 5.1 | CCCCc1nnc(OCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10252966 | 66444 | 0 | None | None | None | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 409 | 5 | 1 | 5 | 5.7 | Cc1cc(SCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL141447 | 66444 | 0 | None | None | None | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 409 | 5 | 1 | 5 | 5.7 | Cc1cc(SCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 127034918 | 273897 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 599 | 11 | 2 | 7 | 6.6 | CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 | 10.1039/C4MD00499J | |||
| CHEMBL3735797 | 273897 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 599 | 11 | 2 | 7 | 6.6 | CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 | 10.1039/C4MD00499J | |||
| 11527144 | 346775 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| CHEMBL47177 | 346775 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@]3(C)C[C@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| 3839 | 8193 | 57 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1016/s0960-894x(02)00303-7 | |||
| 60919 | 8193 | 57 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1016/s0960-894x(02)00303-7 | |||
| 6898 | 8193 | 57 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1016/s0960-894x(02)00303-7 | |||
| CHEMBL432162 | 8193 | 57 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1016/s0960-894x(02)00303-7 | |||
| DB01349 | 8193 | 57 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 411 | 4 | 1 | 6 | 3.4 | Cc1nc(C)c2c(n1)N(Cc1ccc(cc1)c1ccccc1c1nn[nH]n1)C(=O)CC2 | 10.1016/s0960-894x(02)00303-7 | |||
| 9830481 | 387158 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 617 | 8 | 1 | 9 | 5.9 | CCCCc1nc2ccc([C@H]3OC[C@@H]4ON5[C@@H](CCC5(C)C)[C@H]34)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL53244 | 387158 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 617 | 8 | 1 | 9 | 5.9 | CCCCc1nc2ccc([C@H]3OC[C@@H]4ON5[C@@H](CCC5(C)C)[C@H]34)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 15287892 | 200523 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 445 | 9 | 1 | 6 | 5.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2OC)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL289640 | 200523 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 445 | 9 | 1 | 6 | 5.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2OC)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 127035515 | 273894 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735769 | 273894 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44459856 | 196861 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 462 | 7 | 1 | 4 | 6.3 | CCCCc1nc2cc3ccccc3cc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL26277 | 196861 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 462 | 7 | 1 | 4 | 6.3 | CCCCc1nc2cc3ccccc3cc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 11755164 | 238439 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.4 | CCCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347513 | 238439 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.4 | CCCSc1nnc(Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 127037497 | 273938 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 613 | 9 | 2 | 7 | 6.9 | CCCc1nc2c(C)cc(C(=O)NC(C)(C)C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736225 | 273938 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 613 | 9 | 2 | 7 | 6.9 | CCCc1nc2c(C)cc(C(=O)NC(C)(C)C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 73357018 | 183441 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 517 | 8 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(C(=O)Nc3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435834 | 183441 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 517 | 8 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(C(=O)Nc3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 24828707 | 196294 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c2ncccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL259353 | 196294 | 0 | None | None | None | Rat | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 425 | 7 | 1 | 7 | 3.9 | CCCCn1c2ncccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 44377111 | 238593 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 495 | 10 | 1 | 7 | 3.9 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL349020 | 238593 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 495 | 10 | 1 | 7 | 3.9 | CCCCc1ncc(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 53837978 | 5951 | 52 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| 8374 | 5951 | 52 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| 9892451 | 5951 | 52 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| 9937291 | 5951 | 52 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| CHEMBL155836 | 5951 | 52 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| CHEMBL34124 | 5951 | 52 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| CHEMBL4448705 | 5951 | 52 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| DB16266 | 5951 | 52 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 507 | 8 | 1 | 4 | 5.4 | COc1ccc2c(c1OCc1ccccc1)C[C@H](N(C2)C(=O)C(c1ccccc1)c1ccccc1)C(=O)O | 10.1021/acs.jmedchem.9b01780 | |||
| 15654759 | 469045 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 453 | 8 | 3 | 7 | 4.5 | CCCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL70242 | 469045 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 453 | 8 | 3 | 7 | 4.5 | CCCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 197647 | 236913 | 3 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 396 | 6 | 1 | 6 | 4.3 | CCOc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL340612 | 236913 | 3 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 396 | 6 | 1 | 6 | 4.3 | CCOc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| 127028620 | 274924 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 550 | 8 | 3 | 7 | 5.3 | CCCc1nc2c(C)cc(C(=O)NC(C)(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3754198 | 274924 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 550 | 8 | 3 | 7 | 5.3 | CCCc1nc2c(C)cc(C(=O)NC(C)(C)C)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 135723837 | 201785 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 458 | 6 | 2 | 8 | 4.9 | CSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL299269 | 201785 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 458 | 6 | 2 | 8 | 4.9 | CSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 54768876 | 137419 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 521 | 8 | 1 | 8 | 4.9 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccc(C)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL1824002 | 137419 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 521 | 8 | 1 | 8 | 4.9 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccc(C)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| 15654745 | 468891 | 0 | None | None | None | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 452 | 7 | 2 | 6 | 5.1 | CCC(C)c1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL69124 | 468891 | 0 | None | None | None | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 452 | 7 | 2 | 6 | 5.1 | CCC(C)c1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 22850669 | 448189 | 0 | None | None | None | Rabbit | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 44304123 | 448189 | 0 | None | None | None | Rabbit | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 9870914 | 448189 | 0 | None | None | None | Rabbit | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL59913 | 448189 | 0 | None | None | None | Rabbit | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL63109 | 448189 | 0 | None | None | None | Rabbit | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL64881 | 448189 | 0 | None | None | None | Rabbit | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 508 | 11 | 1 | 3 | 5.8 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)[C@@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 44274734 | 182017 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 464 | 8 | 1 | 6 | 5.2 | CCCCc1nc2ccc(CC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL23994 | 182017 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 464 | 8 | 1 | 6 | 5.2 | CCCCc1nc2ccc(CC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 9955424 | 330028 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 7 | 1 | 6 | 4.9 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL422756 | 330028 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 7 | 1 | 6 | 4.9 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10027175 | 39431 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 458 | 9 | 2 | 5 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10049809 | 39431 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 458 | 9 | 2 | 5 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL121874 | 39431 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 458 | 9 | 2 | 5 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331859 | 39431 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 458 | 9 | 2 | 5 | 4.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2Cc2ccccc2)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44274823 | 199302 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 551 | 10 | 2 | 8 | 5.8 | CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL280526 | 199302 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 551 | 10 | 2 | 8 | 5.8 | CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 44277677 | 199531 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 585 | 9 | 1 | 9 | 5.5 | CCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL282168 | 199531 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 585 | 9 | 1 | 9 | 5.5 | CCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 9955424 | 330028 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 7 | 1 | 6 | 4.9 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL422756 | 330028 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 7 | 1 | 6 | 4.9 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 18950592 | 40674 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(C)cc1 | 10.1021/jm00075a033 | |||
| CHEMBL124541 | 40674 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 513 | 11 | 1 | 5 | 7.1 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(C)cc1 | 10.1021/jm00075a033 | |||
| 44285370 | 276570 | 0 | None | None | None | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 388 | 6 | 1 | 5 | 3.9 | CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL37892 | 276570 | 0 | None | None | None | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 388 | 6 | 1 | 5 | 3.9 | CCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 44209671 | 194019 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 478 | 8 | 1 | 6 | 5.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24661 | 194019 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 478 | 8 | 1 | 6 | 5.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 19889336 | 353261 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccncc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| CHEMBL47382 | 353261 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2ccncc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| 44379293 | 238959 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 611 | 10 | 1 | 6 | 6.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL352639 | 238959 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 611 | 10 | 1 | 6 | 6.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccc(F)cc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44315350 | 214915 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311484 | 214915 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 9895984 | 469634 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74476 | 469634 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 661 | 13 | 2 | 8 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC)nc3ccc(NC(=O)N(C)C(C)C)cc3c2=O)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| 44372686 | 196988 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 600 | 4 | 2 | 7 | 6.2 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCC(=O)NS2(=O)=O | 10.1021/jm9504722 | |||
| CHEMBL263714 | 196988 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 600 | 4 | 2 | 7 | 6.2 | CCCc1ccc2c(c1)-c1ccc(cc1)Cn1c(CCC)nc3ccc(cc3c1=O)NCCCCCCC(=O)NS2(=O)=O | 10.1021/jm9504722 | |||
| 14950511 | 333099 | 0 | None | None | None | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 475 | 8 | 1 | 6 | 5.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)c2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL434768 | 333099 | 0 | None | None | None | Guinea pig | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 475 | 8 | 1 | 6 | 5.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)c2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| 10053393 | 103257 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 554 | 12 | 2 | 9 | 5.4 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL156934 | 103257 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 554 | 12 | 2 | 9 | 5.4 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956738 | 470607 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL83180 | 470607 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 465 | 8 | 1 | 7 | 4.6 | CCCCc1nn(-c2ccccc2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 10053393 | 103257 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 554 | 12 | 2 | 9 | 5.4 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156934 | 103257 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 554 | 12 | 2 | 9 | 5.4 | CCCCc1nnc(SCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10026681 | 41806 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 448 | 10 | 2 | 7 | 3.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9981102 | 41806 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 448 | 10 | 2 | 7 | 3.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125940 | 41806 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 448 | 10 | 2 | 7 | 3.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL421074 | 41806 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 448 | 10 | 2 | 7 | 3.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10483597 | 328367 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 592 | 13 | 0 | 9 | 5.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(=O)OC)s2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL419421 | 328367 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 592 | 13 | 0 | 9 | 5.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(C(=O)OC)s2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9915892 | 213344 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 563 | 10 | 2 | 9 | 4.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL308703 | 213344 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 563 | 10 | 2 | 9 | 4.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 9915892 | 213344 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 563 | 10 | 2 | 9 | 4.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL308703 | 213344 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 563 | 10 | 2 | 9 | 4.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9504722 | |||
| 71652858 | 180011 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 623 | 12 | 3 | 8 | 5.4 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2365958 | 180011 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 623 | 12 | 3 | 8 | 5.4 | CCCCc1c[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 44275097 | 199543 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 585 | 10 | 2 | 8 | 6.4 | CCCCc1nc2ccc(NC(=O)OCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL282236 | 199543 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 585 | 10 | 2 | 8 | 6.4 | CCCCc1nc2ccc(NC(=O)OCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 57380414 | 142773 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1947131 | 142773 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 19754062 | 203035 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 604 | 13 | 3 | 7 | 5.9 | CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL306641 | 203035 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 604 | 13 | 3 | 7 | 5.9 | CCCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc3c(C)c(NC(=O)CCC)cnc32)cc1 | 10.1016/S0960-894X(01)81115-X | |||
| 44377067 | 119362 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 495 | 10 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL164059 | 119362 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 495 | 10 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10031920 | 217611 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 628 | 10 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCO2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL319404 | 217611 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 628 | 10 | 1 | 8 | 5.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CCCO2)cc1 | 10.1021/jm00043a020 | |||
| 10078554 | 235837 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL338687 | 235837 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 715 | 12 | 2 | 9 | 6.2 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 136093942 | 276430 | 0 | None | None | None | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 436 | 8 | 1 | 6 | 4.8 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL3786570 | 276430 | 0 | None | None | None | Rat | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 436 | 8 | 1 | 6 | 4.8 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| 44277567 | 201525 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 605 | 8 | 0 | 10 | 4.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccncc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29725 | 201525 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 605 | 8 | 0 | 10 | 4.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccncc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44379184 | 120245 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 602 | 14 | 2 | 7 | 5.9 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL165541 | 120245 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 602 | 14 | 2 | 7 | 5.9 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCCCN)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44305680 | 202808 | 0 | None | None | None | Bovine | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 561 | 9 | 1 | 9 | 3.2 | CCCc1cc(=O)n(CCN2C(=O)c3ccccc3C2=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL305032 | 202808 | 0 | None | None | None | Bovine | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 561 | 9 | 1 | 9 | 3.2 | CCCc1cc(=O)n(CCN2C(=O)c3ccccc3C2=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 44277937 | 201539 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 584 | 10 | 0 | 9 | 5.5 | CCCCCN(C(=O)c1cccnc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29734 | 201539 | 0 | None | None | None | Rabbit | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 584 | 10 | 0 | 9 | 5.5 | CCCCCN(C(=O)c1cccnc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 10183373 | 329922 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 465 | 9 | 1 | 7 | 4.3 | CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL422593 | 329922 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 465 | 9 | 1 | 7 | 4.3 | CCCCc1nn(Cc2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44277420 | 201244 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 603 | 8 | 0 | 8 | 6.1 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29512 | 201244 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 603 | 8 | 0 | 8 | 6.1 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44309701 | 203234 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 609 | 11 | 2 | 7 | 6.3 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| CHEMBL308238 | 203234 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 609 | 11 | 2 | 7 | 6.3 | CCCC(=O)Nc1cnc2c(nc(CCC)n2Cc2ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc2)c1C | 10.1016/S0960-894X(01)81115-X | |||
| 10349897 | 233443 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL333224 | 233443 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 715 | 10 | 2 | 9 | 6.3 | CCCCC(=O)Nc1ccc(Br)c(-n2nc(C)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 10350123 | 120398 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 713 | 12 | 1 | 9 | 6.0 | CCCCc1nc2ccn(CC(=O)N3CCCCC3)c(=O)c2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCc2ccccc2)cc1F | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1668007 | 120398 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 713 | 12 | 1 | 9 | 6.0 | CCCCc1nc2ccn(CC(=O)N3CCCCC3)c(=O)c2n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCc2ccccc2)cc1F | 10.1016/j.bmc.2010.10.043 | |||
| 10460346 | 474377 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 555 | 9 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC#N)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94407 | 474377 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 555 | 9 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC#N)cc1 | 10.1021/jm00043a020 | |||
| 10007306 | 236037 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 534 | 12 | 0 | 7 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccsc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL339404 | 236037 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 534 | 12 | 0 | 7 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccsc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10325483 | 40269 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 560 | 12 | 2 | 8 | 5.1 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(O)c(O)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122982 | 40269 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 560 | 12 | 2 | 8 | 5.1 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(O)c(O)c2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10048770 | 233134 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 438 | 10 | 2 | 5 | 3.9 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCC(C)C)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10478294 | 233134 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 438 | 10 | 2 | 5 | 3.9 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCC(C)C)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL332766 | 233134 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 438 | 10 | 2 | 5 | 3.9 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCC(C)C)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL341070 | 233134 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 438 | 10 | 2 | 5 | 3.9 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCC(C)C)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 14956794 | 470865 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.9 | CCCCc1nn(C(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL85545 | 470865 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 479 | 9 | 1 | 7 | 4.9 | CCCCc1nn(C(C)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44338834 | 22175 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 627 | 11 | 1 | 8 | 7.0 | CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| CHEMBL108981 | 22175 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 627 | 11 | 1 | 8 | 7.0 | CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00073a024 | |||
| 44277871 | 199891 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 599 | 10 | 1 | 9 | 5.8 | CCCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28464 | 199891 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 599 | 10 | 1 | 9 | 5.8 | CCCCCN(C(=O)c1ccc(O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44277594 | 201913 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 619 | 8 | 1 | 9 | 5.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL30015 | 201913 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 619 | 8 | 1 | 9 | 5.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 9935096 | 474642 | 1 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 5.3 | CCCCc1cn([C@@H]2[C@@H](C)CCC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL9599 | 474642 | 1 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 5.3 | CCCCc1cn([C@@H]2[C@@H](C)CCC[C@H]2C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | |||
| 44338834 | 22175 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 627 | 11 | 1 | 8 | 7.0 | CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL108981 | 22175 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 627 | 11 | 1 | 8 | 7.0 | CCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 73350991 | 183433 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 517 | 8 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(NC(=O)c3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| CHEMBL2435826 | 183433 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 517 | 8 | 2 | 4 | 7.3 | CCCc1nc2c(C)cc(NC(=O)c3ccc(C)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2013.08.014 | |||
| 10670376 | 336574 | 0 | None | None | None | Bovine | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 432 | 8 | 3 | 7 | 3.5 | CCCc1nc(C(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL447182 | 336574 | 0 | None | None | None | Bovine | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 432 | 8 | 3 | 7 | 3.5 | CCCc1nc(C(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 44294905 | 372303 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\CC2(CCCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL51084 | 372303 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\CC2(CCCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| 76326259 | 175928 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 598 | 12 | 2 | 10 | 4.2 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237606 | 175928 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 598 | 12 | 2 | 10 | 4.2 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44311429 | 469513 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 649 | 11 | 1 | 8 | 6.8 | CCCc1nc(CC)c(C(=O)OCC#CC(=O)N(c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL73369 | 469513 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 649 | 11 | 1 | 8 | 6.8 | CCCc1nc(CC)c(C(=O)OCC#CC(=O)N(c2ccccc2)c2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 10053412 | 104556 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 555 | 11 | 1 | 9 | 4.6 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)OC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL158115 | 104556 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 555 | 11 | 1 | 9 | 4.6 | CCCCc1nnc([S+]([O-])Cc2ccccc2C(=O)OC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 1610 | 7967 | 67 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/d2md00206j | |||
| 3941 | 7967 | 67 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/d2md00206j | |||
| 3961 | 7967 | 67 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/d2md00206j | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1039/d2md00206j | |||
| 9909335 | 237259 | 0 | None | None | None | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.5 | Cc1cc(OC(C)c2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL341223 | 237259 | 0 | None | None | None | Guinea pig | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.5 | Cc1cc(OC(C)c2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 1610 | 7967 | 67 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| 3941 | 7967 | 67 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| 3961 | 7967 | 67 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00043a020 | |||
| 44305446 | 200896 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 473 | 9 | 2 | 8 | 2.0 | CCCc1cc(=O)n(CCNC(C)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL292781 | 200896 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 473 | 9 | 2 | 8 | 2.0 | CCCc1cc(=O)n(CCNC(C)=O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 10369479 | 237290 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 522 | 15 | 0 | 6 | 6.0 | CCCCCCN1C(=O)N(CCCC)C(=O)/C1=C/c1cnc(CCCC)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL341456 | 237290 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 522 | 15 | 0 | 6 | 6.0 | CCCCCCN1C(=O)N(CCCC)C(=O)/C1=C/c1cnc(CCCC)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 127035715 | 273881 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735652 | 273881 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 76326258 | 175925 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 480 | 9 | 2 | 9 | 2.5 | CCCCc1nnc(S(C)(=O)=O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237603 | 175925 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 480 | 9 | 2 | 9 | 2.5 | CCCCc1nnc(S(C)(=O)=O)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10094614 | 102504 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 437 | 8 | 1 | 8 | 2.9 | CCCCc1nnc(S(C)(=O)=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156307 | 102504 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 437 | 8 | 1 | 8 | 2.9 | CCCCc1nnc(S(C)(=O)=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44298869 | 201727 | 0 | None | None | None | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 452 | 7 | 1 | 7 | 4.2 | CCCOc1nc2cc(C)ccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL298836 | 201727 | 0 | None | None | None | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 452 | 7 | 1 | 7 | 4.2 | CCCOc1nc2cc(C)ccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 44298545 | 392278 | 0 | None | None | None | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 466 | 7 | 1 | 7 | 4.5 | Cc1ccc2nc(OCC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL55939 | 392278 | 0 | None | None | None | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 466 | 7 | 1 | 7 | 4.5 | Cc1ccc2nc(OCC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 | 10.1016/S0960-894X(01)81144-6 | |||
| 71521300 | 177701 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 519 | 6 | 1 | 7 | 5.7 | CCc1nc2ccn(CC3CCCCC3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322442 | 177701 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 519 | 6 | 1 | 7 | 5.7 | CCc1nc2ccn(CC3CCCCC3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 44438872 | 333719 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL440051 | 333719 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCc1nc2cccc(C(=O)OCC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 10391950 | 234101 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 520 | 12 | 1 | 9 | 3.2 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2nn[nH]n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL334326 | 234101 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 520 | 12 | 1 | 9 | 3.2 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2nn[nH]n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44307258 | 468650 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 478 | 5 | 1 | 4 | 5.3 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL67309 | 468650 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 478 | 5 | 1 | 4 | 5.3 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 15780094 | 199998 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 651 | 9 | 1 | 7 | 7.4 | CCc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL285433 | 199998 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 651 | 9 | 1 | 7 | 7.4 | CCc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 70684248 | 157936 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 541 | 9 | 2 | 6 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058588 | 157936 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 541 | 9 | 2 | 6 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 71717082 | 180006 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 623 | 12 | 3 | 8 | 5.4 | CCCCc1n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)c[n+]1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2365904 | 180006 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 623 | 12 | 3 | 8 | 5.4 | CCCCc1n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)c[n+]1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 127035069 | 273843 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 7.7 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735300 | 273843 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 7.7 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 9985434 | 103534 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 568 | 11 | 2 | 6 | 6.9 | CCCCc1nnc(SCc2ccc(C(F)(F)F)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL157185 | 103534 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 568 | 11 | 2 | 6 | 6.9 | CCCCc1nnc(SCc2ccc(C(F)(F)F)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 127035379 | 273944 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736248 | 273944 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 135987614 | 200847 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 455 | 7 | 3 | 8 | 4.6 | CCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL292430 | 200847 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 455 | 7 | 3 | 8 | 4.6 | CCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 44283480 | 200623 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 637 | 9 | 1 | 8 | 7.3 | CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3cccs3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL290768 | 200623 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 637 | 9 | 1 | 8 | 7.3 | CC(C)c1nc2ccc(N(Cc3ccccc3)C(=O)c3cccs3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 9985434 | 103534 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 568 | 11 | 2 | 6 | 6.9 | CCCCc1nnc(SCc2ccc(C(F)(F)F)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157185 | 103534 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 568 | 11 | 2 | 6 | 6.9 | CCCCc1nnc(SCc2ccc(C(F)(F)F)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44297114 | 201911 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.9 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCCCN3O4)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL300105 | 201911 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.9 | CCCCc1nc2ccc([C@@H]3C[C@H]4CCCCN3O4)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 44297216 | 370084 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 575 | 8 | 1 | 9 | 4.9 | CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)CC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL48934 | 370084 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 575 | 8 | 1 | 9 | 4.9 | CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)CC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 15287883 | 198496 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 415 | 8 | 1 | 5 | 4.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL274260 | 198496 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 415 | 8 | 1 | 5 | 4.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 71654382 | 180002 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 701 | 12 | 3 | 8 | 6.2 | CCCCc1c(Br)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2365830 | 180002 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 701 | 12 | 3 | 8 | 6.2 | CCCCc1c(Br)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 1610 | 7967 | 67 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80474-6 | |||
| 3941 | 7967 | 67 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80474-6 | |||
| 3961 | 7967 | 67 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80474-6 | |||
| 135415867 | 1158 | 71 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| 6901 | 1158 | 71 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL57242 | 1158 | 71 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 456 | 7 | 2 | 7 | 4.2 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]oc(=O)n1)c(ccc2)C(=O)O | 10.1016/0960-894X(95)00319-O | |||
| 135487973 | 429032 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 454 | 7 | 2 | 7 | 5.2 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL58938 | 429032 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 454 | 7 | 2 | 7 | 5.2 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 11511750 | 196891 | 2 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 483 | 10 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL262958 | 196891 | 2 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 483 | 10 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 1610 | 7967 | 67 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80914-8 | |||
| 3941 | 7967 | 67 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80914-8 | |||
| 3961 | 7967 | 67 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80914-8 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)80914-8 | |||
| 24827903 | 196342 | 0 | None | None | None | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 477 | 7 | 1 | 7 | 4.7 | CCCCn1c(=O)c2cc(F)c(Cl)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL259575 | 196342 | 0 | None | None | None | Rat | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 477 | 7 | 1 | 7 | 4.7 | CCCCn1c(=O)c2cc(F)c(Cl)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 14956743 | 329058 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL420970 | 329058 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2cccc([N+](=O)[O-])c2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44297046 | 327711 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 551 | 9 | 2 | 9 | 4.3 | CCCCc1nc2ccc([C@H]3C[C@H](CO)ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL433278 | 327711 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 551 | 9 | 2 | 9 | 4.3 | CCCCc1nc2ccc([C@H]3C[C@H](CO)ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 130762 | 198532 | 5 | None | None | None | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00100a007 | |||
| CHEMBL274447 | 198532 | 5 | None | None | None | Guinea pig | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00100a007 | |||
| 127028619 | 274898 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 550 | 11 | 3 | 7 | 5.3 | CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)Nc4nnn[nH]4)cc3)c2c1 | 10.1039/C5MD00169B | |||
| CHEMBL3754010 | 274898 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 550 | 11 | 3 | 7 | 5.3 | CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4C(=O)Nc4nnn[nH]4)cc3)c2c1 | 10.1039/C5MD00169B | |||
| 10478476 | 203095 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 441 | 6 | 3 | 9 | 1.7 | O=c1ccc2c(CO)nc(CO)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm0204237 | |||
| CHEMBL307191 | 203095 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 441 | 6 | 3 | 9 | 1.7 | O=c1ccc2c(CO)nc(CO)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm0204237 | |||
| 44312700 | 469621 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 457 | 6 | 3 | 8 | 2.0 | O=C(O)c1nc(CO)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm0204237 | |||
| CHEMBL74347 | 469621 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 457 | 6 | 3 | 8 | 2.0 | O=C(O)c1nc(CO)nc2c1CCC(=O)N2Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm0204237 | |||
| 44301981 | 200775 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 441 | 5 | 2 | 7 | 2.8 | Cc1nc(C(=O)O)c2c(n1)N(Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CC2 | 10.1016/s0960-894x(02)00303-7 | |||
| CHEMBL291944 | 200775 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 441 | 5 | 2 | 7 | 2.8 | Cc1nc(C(=O)O)c2c(n1)N(Cc1ccc(-c3ccccc3-c3nn[nH]n3)cc1)C(=O)CC2 | 10.1016/s0960-894x(02)00303-7 | |||
| 10478476 | 203095 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 441 | 6 | 3 | 9 | 1.7 | O=c1ccc2c(CO)nc(CO)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/s0960-894x(02)00303-7 | |||
| CHEMBL307191 | 203095 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 441 | 6 | 3 | 9 | 1.7 | O=c1ccc2c(CO)nc(CO)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/s0960-894x(02)00303-7 | |||
| 127026043 | 274756 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 607 | 11 | 3 | 9 | 3.8 | CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752947 | 274756 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 607 | 11 | 3 | 9 | 3.8 | CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 44300827 | 201878 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 602 | 8 | 1 | 7 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc([Si](C)(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL299897 | 201878 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 602 | 8 | 1 | 7 | 6.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc([Si](C)(C)C)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 44211708 | 200827 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 416 | 7 | 1 | 7 | 2.8 | CCCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL292316 | 200827 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 416 | 7 | 1 | 7 | 2.8 | CCCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 44307087 | 468763 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 401 | 6 | 1 | 5 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL68111 | 468763 | 0 | None | None | None | Rabbit | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 401 | 6 | 1 | 5 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| 19792146 | 202009 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 500 | 8 | 1 | 7 | 5.7 | CCCCc1nc2cc(Cl)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL300861 | 202009 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 500 | 8 | 1 | 7 | 5.7 | CCCCc1nc2cc(Cl)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 15069407 | 372764 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2ccc(C(=O)OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51508 | 372764 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2ccc(C(=O)OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 15654700 | 328723 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 470 | 7 | 1 | 8 | 4.8 | CCSc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL420551 | 328723 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 470 | 7 | 1 | 8 | 4.8 | CCSc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 15654749 | 468812 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 454 | 8 | 2 | 7 | 4.2 | CCOCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL68494 | 468812 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 454 | 8 | 2 | 7 | 4.2 | CCOCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 14952903 | 390578 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 380 | 9 | 1 | 4 | 5.0 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1 | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL55508 | 390578 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 380 | 9 | 1 | 4 | 5.0 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1 | 10.1016/S0960-894X(01)81116-1 | |||
| 15069407 | 372764 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2ccc(C(=O)OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51508 | 372764 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2ccc(C(=O)OC)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792146 | 202009 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 500 | 8 | 1 | 7 | 5.7 | CCCCc1nc2cc(Cl)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL300861 | 202009 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 500 | 8 | 1 | 7 | 5.7 | CCCCc1nc2cc(Cl)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44298808 | 202085 | 0 | None | None | None | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 424 | 6 | 1 | 7 | 3.5 | CCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL301479 | 202085 | 0 | None | None | None | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 424 | 6 | 1 | 7 | 3.5 | CCOc1nc2ccccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 10255888 | 158287 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 4.2 | CCCCc1c(I)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063982 | 158287 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 4.2 | CCCCc1c(I)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 10255888 | 158287 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 4.2 | CCCCc1c(I)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063982 | 158287 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 514 | 8 | 2 | 6 | 4.2 | CCCCc1c(I)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 44210836 | 119308 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 453 | 6 | 1 | 8 | 3.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(c1ccccc1)(c1nn[nH]n1)O2 | 10.1016/S0960-894X(01)80193-1 | |||
| CHEMBL163523 | 119308 | 0 | None | None | None | Rabbit | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 453 | 6 | 1 | 8 | 3.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(c1ccccc1)(c1nn[nH]n1)O2 | 10.1016/S0960-894X(01)80193-1 | |||
| 70694736 | 157871 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 472 | 6 | 1 | 6 | 5.5 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(C)nc4ccccc43)cc2)c1C | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058367 | 157871 | 0 | None | None | None | Bovine | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 472 | 6 | 1 | 6 | 5.5 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(C)nc4ccccc43)cc2)c1C | 10.1016/j.bmc.2012.06.011 | |||
| 71521506 | 177683 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 514 | 6 | 1 | 8 | 4.6 | CCc1nc2ccn(Cc3cccnc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322172 | 177683 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 514 | 6 | 1 | 8 | 4.6 | CCc1nc2ccn(Cc3cccnc3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 19792159 | 385805 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.8 | CCCCc1nc2cccc(CO)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52398 | 385805 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.8 | CCCCc1nc2cccc(CO)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792159 | 385805 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.8 | CCCCc1nc2cccc(CO)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52398 | 385805 | 0 | None | None | None | Bovine | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.8 | CCCCc1nc2cccc(CO)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44296550 | 371981 | 0 | None | None | None | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 407 | 9 | 2 | 4 | 4.7 | CCCc1cc(COC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL50592 | 371981 | 0 | None | None | None | Bovine | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 407 | 9 | 2 | 4 | 4.7 | CCCc1cc(COC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 10642524 | 23923 | 1 | None | None | None | Bovine | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.9 | CCCc1nc(C(=O)O)cn1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL112637 | 23923 | 1 | None | None | None | Bovine | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.9 | CCCc1nc(C(=O)O)cn1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 44303859 | 450985 | 0 | None | None | None | Rabbit | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 514 | 8 | 1 | 3 | 5.8 | CCCCCN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL60209 | 450985 | 0 | None | None | None | Rabbit | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 514 | 8 | 1 | 3 | 5.8 | CCCCCN(C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccccc2)C[C@H]1C(=O)O)c1ccccc1 | 10.1016/S0960-894X(01)81007-6 | |||
| 15654716 | 213507 | 0 | None | None | None | Bovine | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(C(=O)O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL308911 | 213507 | 0 | None | None | None | Bovine | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(C(=O)O)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 10047444 | 200512 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.7 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL289543 | 200512 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.7 | CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccccc1Cl | 10.1016/S0960-894X(01)81116-1 | |||
| 9910561 | 24348 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 430 | 8 | 2 | 6 | 4.6 | CCCc1nc(C(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL115206 | 24348 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 430 | 8 | 2 | 6 | 4.6 | CCCc1nc(C(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 9867026 | 468897 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 424 | 6 | 2 | 6 | 4.2 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL69154 | 468897 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 424 | 6 | 2 | 6 | 4.2 | CCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 10004855 | 235621 | 0 | None | None | None | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 432 | 6 | 1 | 6 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(C#N)cc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL337380 | 235621 | 0 | None | None | None | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 432 | 6 | 1 | 6 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccc(C#N)cc2n1 | 10.1021/jm00100a007 | |||
| 10621927 | 220381 | 0 | None | None | None | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 418 | 8 | 3 | 7 | 2.9 | CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL326086 | 220381 | 0 | None | None | None | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 418 | 8 | 3 | 7 | 2.9 | CCCc1nc(C(=O)O)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 10094965 | 42782 | 0 | None | None | None | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.3 | Cc1nc2ccccc2c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C | 10.1021/jm00100a007 | |||
| CHEMBL128536 | 42782 | 0 | None | None | None | Guinea pig | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.3 | Cc1nc2ccccc2c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C | 10.1021/jm00100a007 | |||
| 24828708 | 315575 | 0 | None | None | None | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 459 | 7 | 1 | 7 | 4.5 | CCCCn1c2nc(Cl)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL410487 | 315575 | 0 | None | None | None | Rat | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 459 | 7 | 1 | 7 | 4.5 | CCCCn1c2nc(Cl)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 127037496 | 273847 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 613 | 12 | 2 | 7 | 6.9 | CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 | 10.1039/C4MD00499J | |||
| CHEMBL3735311 | 273847 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 613 | 12 | 2 | 7 | 6.9 | CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 | 10.1039/C4MD00499J | |||
| 127035067 | 273837 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 683 | 12 | 2 | 9 | 5.4 | CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735236 | 273837 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 683 | 12 | 2 | 9 | 5.4 | CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 10482340 | 41514 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 537 | 11 | 0 | 9 | 4.2 | CCCCc1ncc(/C=C2/C(=O)N(COC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125835 | 41514 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 537 | 11 | 0 | 9 | 4.2 | CCCCc1ncc(/C=C2/C(=O)N(COC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10325295 | 237001 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 551 | 12 | 1 | 9 | 4.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCO)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL340882 | 237001 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 551 | 12 | 1 | 9 | 4.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCO)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44295090 | 201771 | 0 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL299151 | 201771 | 0 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 10343392 | 44004 | 0 | None | None | None | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.3 | Cc1ccc2nc(C)cc(OCc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1021/jm00100a007 | |||
| CHEMBL130455 | 44004 | 0 | None | None | None | Guinea pig | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 407 | 5 | 1 | 5 | 5.3 | Cc1ccc2nc(C)cc(OCc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c2c1 | 10.1021/jm00100a007 | |||
| 44309268 | 468842 | 0 | None | None | None | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 308 | 5 | 1 | 3 | 4.8 | CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c(C)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL68713 | 468842 | 0 | None | None | None | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 308 | 5 | 1 | 3 | 4.8 | CCCCc1nc2ccccc2n1Cc1cc(C)c(O)c(C)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 76329884 | 175926 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 590 | 11 | 2 | 9 | 4.7 | CCCCc1nnc(S(=O)(=O)Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237604 | 175926 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 590 | 11 | 2 | 9 | 4.7 | CCCCc1nnc(S(=O)(=O)Cc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44210646 | 42960 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 427 | 7 | 2 | 7 | 3.7 | CCCc1cn2ncc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL128920 | 42960 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 427 | 7 | 2 | 7 | 3.7 | CCCc1cn2ncc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| 10395045 | 238453 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 547 | 10 | 1 | 8 | 5.1 | CCCCc1nnc(S(=O)(=O)Cc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347630 | 238453 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 547 | 10 | 1 | 8 | 5.1 | CCCCc1nnc(S(=O)(=O)Cc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44316916 | 214470 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 474 | 12 | 4 | 5 | 4.2 | CCCCc1ncc(CN[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1016/0960-894X(94)00456-P | |||
| 44317214 | 214470 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 474 | 12 | 4 | 5 | 4.2 | CCCCc1ncc(CN[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1016/0960-894X(94)00456-P | |||
| CHEMBL310752 | 214470 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 474 | 12 | 4 | 5 | 4.2 | CCCCc1ncc(CN[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1016/0960-894X(94)00456-P | |||
| CHEMBL79242 | 214470 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 474 | 12 | 4 | 5 | 4.2 | CCCCc1ncc(CN[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1016/0960-894X(94)00456-P | |||
| 11744700 | 238408 | 0 | None | None | None | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 454 | 11 | 3 | 7 | 3.7 | CCCCc1nnc(SCCO)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL347234 | 238408 | 0 | None | None | None | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 454 | 11 | 3 | 7 | 3.7 | CCCCc1nnc(SCCO)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 135723851 | 200967 | 0 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 472 | 7 | 2 | 8 | 5.3 | CCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL293308 | 200967 | 0 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 472 | 7 | 2 | 8 | 5.3 | CCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 11744700 | 238408 | 0 | None | None | None | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 454 | 11 | 3 | 7 | 3.7 | CCCCc1nnc(SCCO)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347234 | 238408 | 0 | None | None | None | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 454 | 11 | 3 | 7 | 3.7 | CCCCc1nnc(SCCO)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10253216 | 103955 | 0 | None | None | None | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 450 | 7 | 2 | 6 | 4.4 | CCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL157597 | 103955 | 0 | None | None | None | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 450 | 7 | 2 | 6 | 4.4 | CCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10253216 | 103955 | 0 | None | None | None | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 450 | 7 | 2 | 6 | 4.4 | CCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157597 | 103955 | 0 | None | None | None | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 450 | 7 | 2 | 6 | 4.4 | CCSc1nnc(C(F)(F)F)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 127035392 | 273936 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 563 | 10 | 2 | 5 | 7.4 | CCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736202 | 273936 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 563 | 10 | 2 | 5 | 7.4 | CCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 11757293 | 238549 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 550 | 11 | 2 | 6 | 7.1 | CCCCc1nnc(SCc2ccc3ccccc3c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL348568 | 238549 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 550 | 11 | 2 | 6 | 7.1 | CCCCc1nnc(SCc2ccc3ccccc3c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 11757293 | 238549 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 550 | 11 | 2 | 6 | 7.1 | CCCCc1nnc(SCc2ccc3ccccc3c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL348568 | 238549 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 550 | 11 | 2 | 6 | 7.1 | CCCCc1nnc(SCc2ccc3ccccc3c2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 14956799 | 216555 | 0 | None | None | None | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL314590 | 216555 | 0 | None | None | None | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(Cc2ccccc2C(=O)O)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 130762 | 198532 | 5 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL274447 | 198532 | 5 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 130762 | 198532 | 5 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL274447 | 198532 | 5 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 8 | 2 | 4 | 4.8 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 15654730 | 469164 | 1 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 440 | 6 | 1 | 8 | 3.7 | COC(=O)c1cccc2nc(OC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1021/jm00067a016 | |||
| CHEMBL71038 | 469164 | 1 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 440 | 6 | 1 | 8 | 3.7 | COC(=O)c1cccc2nc(OC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1021/jm00067a016 | |||
| 44298546 | 200843 | 0 | None | None | None | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 510 | 8 | 1 | 9 | 4.1 | CCOC(=O)c1ccc2nc(OC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL292412 | 200843 | 0 | None | None | None | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 510 | 8 | 1 | 9 | 4.1 | CCOC(=O)c1ccc2nc(OC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 | 10.1016/S0960-894X(01)81144-6 | |||
| 127036105 | 273955 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736336 | 273955 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44209951 | 182971 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 4.6 | CCCCc1nc2ccc(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24240 | 182971 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 4.6 | CCCCc1nc2ccc(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44209671 | 194019 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 478 | 8 | 1 | 6 | 5.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24661 | 194019 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 478 | 8 | 1 | 6 | 5.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44274671 | 194645 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 479 | 8 | 1 | 7 | 4.7 | CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25000 | 194645 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 479 | 8 | 1 | 7 | 4.7 | CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 14956748 | 470771 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccc(OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL84627 | 470771 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccc(OC)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44209951 | 182971 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 4.6 | CCCCc1nc2ccc(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL24240 | 182971 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 4.6 | CCCCc1nc2ccc(OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 9870463 | 202336 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 495 | 5 | 1 | 6 | 4.8 | CCCc1nc2c(C)cc(C(=O)OC)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL303147 | 202336 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 495 | 5 | 1 | 6 | 4.8 | CCCc1nc2c(C)cc(C(=O)OC)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 9887844 | 328199 | 5 | None | None | None | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL418226 | 328199 | 5 | None | None | None | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/j.bmc.2010.10.043 | |||
| 9870463 | 202336 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 495 | 5 | 1 | 6 | 4.8 | CCCc1nc2c(C)cc(C(=O)OC)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL303147 | 202336 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 495 | 5 | 1 | 6 | 4.8 | CCCc1nc2c(C)cc(C(=O)OC)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/j.bmc.2010.10.043 | |||
| 9887844 | 328199 | 5 | None | None | None | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL418226 | 328199 | 5 | None | None | None | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 44275108 | 195141 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 513 | 8 | 1 | 7 | 5.7 | CCCCc1nc2ccc(-c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL25313 | 195141 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 513 | 8 | 1 | 7 | 5.7 | CCCCc1nc2ccc(-c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 127035717 | 270460 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735409 | 270460 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10053595 | 203166 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 562 | 10 | 2 | 8 | 4.8 | CCCc1nc(CN2CCN(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL307756 | 203166 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 562 | 10 | 2 | 8 | 4.8 | CCCc1nc(CN2CCN(c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311738 | 469119 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 590 | 10 | 2 | 8 | 4.4 | CCCc1nc(CN2CCN(C(=O)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL70801 | 469119 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 590 | 10 | 2 | 8 | 4.4 | CCCc1nc(CN2CCN(C(=O)c3ccccc3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44379334 | 120903 | 1 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 585 | 10 | 2 | 9 | 4.2 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL167584 | 120903 | 1 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 585 | 10 | 2 | 9 | 4.2 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10054912 | 474516 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 640 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccsc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL95197 | 474516 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 640 | 10 | 1 | 8 | 6.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccsc2)cc1 | 10.1021/jm00043a020 | |||
| 44373417 | 105609 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 476 | 5 | 1 | 8 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2cccc(-c3nn[nH]n3)c2)c1 | 10.1021/jm9504722 | |||
| CHEMBL159004 | 105609 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 476 | 5 | 1 | 8 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(ccn2C(=O)c2cccc(-c3nn[nH]n3)c2)c1 | 10.1021/jm9504722 | |||
| 14950508 | 199769 | 0 | None | None | None | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 429 | 7 | 1 | 7 | 4.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL283742 | 199769 | 0 | None | None | None | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 429 | 7 | 1 | 7 | 4.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(C)n1 | 10.1021/jm00061a016 | |||
| 15171368 | 332799 | 0 | None | None | None | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 443 | 8 | 1 | 7 | 4.4 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(CC)n1 | 10.1021/jm00061a016 | |||
| CHEMBL432459 | 332799 | 0 | None | None | None | Guinea pig | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 443 | 8 | 1 | 7 | 4.4 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(CC)n1 | 10.1021/jm00061a016 | |||
| 15287890 | 311701 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 429 | 8 | 1 | 5 | 5.3 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL40585 | 311701 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 429 | 8 | 1 | 5 | 5.3 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 44277574 | 202008 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL30086 | 202008 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 15231094 | 276616 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 641 | 12 | 1 | 8 | 7.4 | CCCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL37919 | 276616 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 641 | 12 | 1 | 8 | 7.4 | CCCCc1nc2ccc(N(Cc3ccccc3)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 71521302 | 177703 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 527 | 6 | 1 | 7 | 5.5 | CCc1nc2ccn(Cc3ccccc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322444 | 177703 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 527 | 6 | 1 | 7 | 5.5 | CCc1nc2ccn(Cc3ccccc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 44348355 | 232435 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 591 | 13 | 1 | 6 | 8.6 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Oc2ccccc2)cc1 | 10.1021/jm00075a033 | |||
| CHEMBL331797 | 232435 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 591 | 13 | 1 | 6 | 8.6 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc(Oc2ccccc2)cc1 | 10.1021/jm00075a033 | |||
| 53309406 | 136116 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 511 | 6 | 1 | 6 | 6.3 | CCc1nc2c(C)cc(Cc3ccccc3)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801743 | 136116 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 511 | 6 | 1 | 6 | 6.3 | CCc1nc2c(C)cc(Cc3ccccc3)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 10349256 | 220957 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 647 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2nc3ccccc3o2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL327569 | 220957 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 647 | 10 | 1 | 8 | 7.1 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2nc3ccccc3o2)cc1 | 10.1021/jm00043a020 | |||
| 44300615 | 393875 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 572 | 9 | 1 | 7 | 6.5 | CCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL56549 | 393875 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 572 | 9 | 1 | 7 | 6.5 | CCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| 10257584 | 41005 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 577 | 14 | 0 | 8 | 6.2 | CCCCCCN1C(=O)/C(=C/c2cnc(CCCC)n2Cc2ccc(C(=O)OC)cc2)N(Cc2csc(C)n2)C1=O | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125533 | 41005 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 577 | 14 | 0 | 8 | 6.2 | CCCCCCN1C(=O)/C(=C/c2cnc(CCCC)n2Cc2ccc(C(=O)OC)cc2)N(Cc2csc(C)n2)C1=O | 10.1007/s00044-009-9205-9 | |||
| 10765180 | 24538 | 0 | None | None | None | Bovine | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 432 | 7 | 3 | 7 | 3.3 | CCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL116094 | 24538 | 0 | None | None | None | Bovine | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 432 | 7 | 3 | 7 | 3.3 | CCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 10004112 | 59220 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 454 | 9 | 1 | 5 | 5.5 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm9504722 | |||
| CHEMBL135089 | 59220 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 454 | 9 | 1 | 5 | 5.5 | C=CCN(c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1)C(C(=O)O)c1ccccc1 | 10.1021/jm9504722 | |||
| 44277489 | 200573 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccncc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29020 | 200573 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccncc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 1610 | 7967 | 67 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| 3941 | 7967 | 67 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| 3961 | 7967 | 67 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(00)80076-1 | |||
| 10439612 | 317370 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 688 | 10 | 1 | 7 | 6.8 | O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1 | 10.1021/jm00043a020 | |||
| CHEMBL414816 | 317370 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 688 | 10 | 1 | 7 | 6.8 | O=C(NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCCC(F)(F)F)nn(-c3ccccc3C(F)(F)F)c2=O)cc1)c1ccccc1 | 10.1021/jm00043a020 | |||
| 10439172 | 474372 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 644 | 13 | 2 | 8 | 5.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC(=O)O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94355 | 474372 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 644 | 13 | 2 | 8 | 5.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)CCCC(=O)O)cc1 | 10.1021/jm00043a020 | |||
| 14956758 | 216199 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL314042 | 216199 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 509 | 9 | 1 | 9 | 4.1 | CCCCc1nn(-c2ccccc2C(=O)OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 9931685 | 470871 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL85595 | 470871 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 415 | 10 | 1 | 6 | 4.9 | CCCCc1nc(CCCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1016/j.bmc.2010.10.043 | |||
| 44379335 | 238894 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 574 | 10 | 2 | 6 | 6.0 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL352137 | 238894 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 574 | 10 | 2 | 6 | 6.0 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC(C)C)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44379348 | 329835 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 558 | 10 | 1 | 7 | 4.7 | CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL422374 | 329835 | 0 | None | None | None | Rabbit | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 558 | 10 | 1 | 7 | 4.7 | CCCCc1nc2ccc(N(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 1610 | 7967 | 67 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| 3941 | 7967 | 67 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| 3961 | 7967 | 67 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| 1610 | 7967 | 67 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.12.044 | |||
| 3941 | 7967 | 67 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.12.044 | |||
| 3961 | 7967 | 67 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.12.044 | |||
| 14956769 | 216759 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 499 | 9 | 1 | 7 | 5.3 | CCCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL316052 | 216759 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 499 | 9 | 1 | 7 | 5.3 | CCCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44277443 | 200466 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.0 | CCCCC(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28918 | 200466 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.0 | CCCCC(=O)N(Cc1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44310609 | 468742 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.3 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| CHEMBL67919 | 468742 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.3 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| 10008962 | 238041 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 615 | 10 | 2 | 8 | 5.4 | CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| CHEMBL343719 | 238041 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 615 | 10 | 2 | 8 | 5.4 | CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1007/s00044-013-0831-x | |||
| 10369701 | 40184 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 529 | 12 | 0 | 7 | 5.1 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccccn2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122494 | 40184 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 529 | 12 | 0 | 7 | 5.1 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccccn2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 14956762 | 199071 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.6 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL278741 | 199071 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.6 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 14956762 | 199071 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.6 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| CHEMBL278741 | 199071 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.6 | CCCCc1nn(-c2c(Cl)cccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81132-X | |||
| 44377123 | 238671 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 481 | 10 | 2 | 6 | 3.9 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL349856 | 238671 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 481 | 10 | 2 | 6 | 3.9 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10100723 | 474339 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 646 | 9 | 1 | 7 | 6.1 | CC1CC1Cc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL94176 | 474339 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 646 | 9 | 1 | 7 | 6.1 | CC1CC1Cc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 44315282 | 196958 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL263452 | 196958 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 683 | 10 | 2 | 7 | 6.4 | CCc1ccc(C(=O)NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(CC)nc4ccc(NC(=O)N(C)C(C)C)cc4c3=O)c(F)c2)cc1 | 10.1016/0960-894X(94)85036-4 | |||
| 10008962 | 238041 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 615 | 10 | 2 | 8 | 5.4 | CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL343719 | 238041 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 615 | 10 | 2 | 8 | 5.4 | CCCCc1nn(-c2cccc(N)c2)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)cc1 | 10.1021/jm00052a006 | |||
| 44379217 | 120940 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 608 | 10 | 2 | 6 | 7.1 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Nc2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL167929 | 120940 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 608 | 10 | 2 | 6 | 7.1 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)Nc2ccccc2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 10416957 | 220998 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 662 | 10 | 1 | 7 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2c(C)cccc2C)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL327791 | 220998 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 662 | 10 | 1 | 7 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2c(C)cccc2C)cc1 | 10.1021/jm00043a020 | |||
| 10372810 | 215881 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 735 | 13 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| CHEMBL313868 | 215881 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 735 | 13 | 2 | 8 | 7.1 | CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(-c2cc(CCC)ccc2S(=O)(=O)NC(=O)c2ccccc2F)cc1F | 10.1016/S0960-894X(01)80595-3 | |||
| 135723852 | 276473 | 0 | None | None | None | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL3787050 | 276473 | 0 | None | None | None | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| 44274745 | 182588 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 633 | 8 | 3 | 8 | 6.3 | CC(=O)Nc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL24111 | 182588 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 633 | 8 | 3 | 8 | 6.3 | CC(=O)Nc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10370801 | 101681 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 570 | 12 | 2 | 9 | 4.4 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL155554 | 101681 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 570 | 12 | 2 | 9 | 4.4 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 127035082 | 273948 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 677 | 12 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736262 | 273948 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 677 | 12 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 1610 | 7967 | 67 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | |||
| 3941 | 7967 | 67 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | |||
| 3961 | 7967 | 67 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00057a009 | |||
| 9984390 | 238286 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 527 | 11 | 1 | 8 | 4.8 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345826 | 238286 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 527 | 11 | 1 | 8 | 4.8 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 1610 | 7967 | 67 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| 3941 | 7967 | 67 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| 3961 | 7967 | 67 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00050a002 | |||
| 9888820 | 24269 | 39 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 428 | 8 | 2 | 6 | 4.5 | C=C(C)c1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1021/jm950450f | |||
| CHEMBL114752 | 24269 | 39 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 428 | 8 | 2 | 6 | 4.5 | C=C(C)c1nc(CCC)n(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)O | 10.1021/jm950450f | |||
| 44376992 | 119918 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 1 | 7 | 4.1 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL164552 | 119918 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 1 | 7 | 4.1 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 9953638 | 176010 | 0 | None | None | None | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 415 | 6 | 1 | 7 | 3.9 | COC(=O)c1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1021/jm00061a016 | |||
| CHEMBL22426 | 176010 | 0 | None | None | None | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 415 | 6 | 1 | 7 | 3.9 | COC(=O)c1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1021/jm00061a016 | |||
| 9887844 | 328199 | 5 | None | None | None | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1021/jm00061a016 | |||
| CHEMBL418226 | 328199 | 5 | None | None | None | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 411 | 6 | 1 | 5 | 4.9 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1021/jm00061a016 | |||
| 19385729 | 104114 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 471 | 7 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)(C)C)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15774 | 104114 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 471 | 7 | 1 | 5 | 6.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)(C)C)c1 | 10.1016/0960-894X(95)00185-V | |||
| 9869596 | 234246 | 0 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 476 | 7 | 2 | 8 | 5.1 | CCSc1nc2c(C)sc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL334838 | 234246 | 0 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 476 | 7 | 2 | 8 | 5.1 | CCSc1nc2c(C)sc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| 71653009 | 180012 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 575 | 12 | 3 | 4 | 6.4 | CCCCc1c[n+](Cc2ccc(-c3ccccc3C(=O)O)cc2)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2366019 | 180012 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 575 | 12 | 3 | 4 | 6.4 | CCCCc1c[n+](Cc2ccc(-c3ccccc3C(=O)O)cc2)c(CO)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 127035557 | 273873 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 587 | 10 | 2 | 7 | 6.9 | CCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735558 | 273873 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 587 | 10 | 2 | 7 | 6.9 | CCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44306646 | 468066 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 504 | 7 | 1 | 6 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2NS(=O)(=O)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL63280 | 468066 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 504 | 7 | 1 | 6 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(Oc2ccccc2NS(=O)(=O)C(F)(F)F)cc1 | 10.1016/S0960-894X(01)81148-3 | |||
| 10646584 | 24549 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 436 | 9 | 3 | 5 | 4.6 | CCCc1nc(C(C)(O)CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL116102 | 24549 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 436 | 9 | 3 | 5 | 4.6 | CCCc1nc(C(C)(O)CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 22850667 | 449701 | 0 | None | None | None | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 542 | 11 | 1 | 3 | 6.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL60071 | 449701 | 0 | None | None | None | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 542 | 11 | 1 | 3 | 6.5 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Cl)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 57380213 | 142770 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 517 | 9 | 2 | 4 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1947128 | 142770 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 517 | 9 | 2 | 4 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 44305654 | 200926 | 0 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 502 | 8 | 1 | 8 | 4.8 | CCCCc1cc(=O)n2nc(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL293001 | 200926 | 0 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 502 | 8 | 1 | 8 | 4.8 | CCCCc1cc(=O)n2nc(-c3ccccc3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 10071111 | 238373 | 0 | None | None | None | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 426 | 9 | 2 | 7 | 3.5 | CCSc1nnc(COC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL346742 | 238373 | 0 | None | None | None | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 426 | 9 | 2 | 7 | 3.5 | CCSc1nnc(COC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10071111 | 238373 | 0 | None | None | None | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 426 | 9 | 2 | 7 | 3.5 | CCSc1nnc(COC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL346742 | 238373 | 0 | None | None | None | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 426 | 9 | 2 | 7 | 3.5 | CCSc1nnc(COC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 24827772 | 196146 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.3 | CCCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL258685 | 196146 | 0 | None | None | None | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.3 | CCCCCn1c(=O)c2cccnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 44297144 | 332758 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 617 | 8 | 1 | 9 | 5.9 | CCCCc1nc2ccc([C@H]3OC[C@H]4[C@@H]3ON3[C@@H]4CCC3(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL432128 | 332758 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 617 | 8 | 1 | 9 | 5.9 | CCCCc1nc2ccc([C@H]3OC[C@H]4[C@@H]3ON3[C@@H]4CCC3(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 127026042 | 274662 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 620 | 11 | 3 | 9 | 3.8 | CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3751986 | 274662 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 620 | 11 | 3 | 9 | 3.8 | CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 127036867 | 274785 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 614 | 11 | 3 | 8 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3753134 | 274785 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 614 | 11 | 3 | 8 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 15287884 | 311227 | 0 | None | None | None | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 449 | 8 | 1 | 5 | 5.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccc(Cl)cc2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL40273 | 311227 | 0 | None | None | None | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 449 | 8 | 1 | 5 | 5.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccc(Cl)cc2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 51529932 | 1680 | 26 | None | None | None | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 387 | 8 | 1 | 2 | 5.8 | CCCCC(=O)N(c1ccccc1)Cc1ccc(cc1)c1ccccc1C(=O)O | 10.1021/acs.jmedchem.4c01617 | |||
| 6161 | 1680 | 26 | None | None | None | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 387 | 8 | 1 | 2 | 5.8 | CCCCC(=O)N(c1ccccc1)Cc1ccc(cc1)c1ccccc1C(=O)O | 10.1021/acs.jmedchem.4c01617 | |||
| CHEMBL4637519 | 1680 | 26 | None | None | None | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 387 | 8 | 1 | 2 | 5.8 | CCCCC(=O)N(c1ccccc1)Cc1ccc(cc1)c1ccccc1C(=O)O | 10.1021/acs.jmedchem.4c01617 | |||
| 51529932 | 1680 | 26 | None | None | None | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 387 | 8 | 1 | 2 | 5.8 | CCCCC(=O)N(c1ccccc1)Cc1ccc(cc1)c1ccccc1C(=O)O | 10.1021/acs.jmedchem.4c01617 | |||
| 6161 | 1680 | 26 | None | None | None | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 387 | 8 | 1 | 2 | 5.8 | CCCCC(=O)N(c1ccccc1)Cc1ccc(cc1)c1ccccc1C(=O)O | 10.1021/acs.jmedchem.4c01617 | |||
| CHEMBL4637519 | 1680 | 26 | None | None | None | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 387 | 8 | 1 | 2 | 5.8 | CCCCC(=O)N(c1ccccc1)Cc1ccc(cc1)c1ccccc1C(=O)O | 10.1021/acs.jmedchem.4c01617 | |||
| 15171420 | 473637 | 0 | None | None | None | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 425 | 6 | 1 | 5 | 5.3 | CCc1cc(OCc2ccc(-c3ccc(C)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL89614 | 473637 | 0 | None | None | None | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 425 | 6 | 1 | 5 | 5.3 | CCc1cc(OCc2ccc(-c3ccc(C)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 44352199 | 45838 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 423 | 7 | 1 | 6 | 5.0 | CCCCc1nc2c(C)cncc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| CHEMBL132109 | 45838 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 423 | 7 | 1 | 6 | 5.0 | CCCCc1nc2c(C)cncc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81118-5 | |||
| 1610 | 7967 | 67 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a033 | |||
| 3941 | 7967 | 67 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a033 | |||
| 3961 | 7967 | 67 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a033 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00075a033 | |||
| 14950504 | 176431 | 0 | None | None | None | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 443 | 8 | 1 | 7 | 4.6 | CCCc1nc(C)cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)OC | 10.1021/jm00061a016 | |||
| CHEMBL22692 | 176431 | 0 | None | None | None | Guinea pig | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 443 | 8 | 1 | 7 | 4.6 | CCCc1nc(C)cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c1C(=O)OC | 10.1021/jm00061a016 | |||
| 10052319 | 328319 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 518 | 12 | 1 | 7 | 4.4 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c[nH]cn2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL419058 | 328319 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 518 | 12 | 1 | 7 | 4.4 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2c[nH]cn2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9807638 | 370397 | 0 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\CC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL49192 | 370397 | 0 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\CC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| 11743916 | 238217 | 0 | None | None | None | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 439 | 10 | 1 | 7 | 4.3 | CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345127 | 238217 | 0 | None | None | None | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 439 | 10 | 1 | 7 | 4.3 | CCCCc1nnc(SCC(=O)OC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 19792121 | 372567 | 0 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 493 | 9 | 2 | 6 | 5.4 | CCCCc1nc2cccc(C(=O)NC(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51340 | 372567 | 0 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 493 | 9 | 2 | 6 | 5.4 | CCCCc1nc2cccc(C(=O)NC(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44303884 | 467909 | 0 | None | None | None | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 586 | 11 | 1 | 3 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(Br)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL62422 | 467909 | 0 | None | None | None | Rabbit | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 586 | 11 | 1 | 3 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(Br)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 44459611 | 200267 | 0 | None | None | None | Bovine | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 568 | 7 | 2 | 7 | 5.9 | COc1ccc(-c2nc3cc(C4=NN(Cc5ccc(-c6ccccc6-c6nn[nH]n6)cc5)C(=O)CC4C)ccc3[nH]2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| CHEMBL287374 | 200267 | 0 | None | None | None | Bovine | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 568 | 7 | 2 | 7 | 5.9 | COc1ccc(-c2nc3cc(C4=NN(Cc5ccc(-c6ccccc6-c6nn[nH]n6)cc5)C(=O)CC4C)ccc3[nH]2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| 19792121 | 372567 | 0 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 493 | 9 | 2 | 6 | 5.4 | CCCCc1nc2cccc(C(=O)NC(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51340 | 372567 | 0 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 493 | 9 | 2 | 6 | 5.4 | CCCCc1nc2cccc(C(=O)NC(C)C)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 127036868 | 274766 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 614 | 11 | 3 | 8 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3753007 | 274766 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 614 | 11 | 3 | 8 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 10001717 | 101511 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 412 | 7 | 1 | 7 | 4.1 | CCCCc1nn2cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155305 | 101511 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 412 | 7 | 1 | 7 | 4.1 | CCCCc1nn2cc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 9985840 | 238716 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 426 | 8 | 1 | 7 | 4.3 | CCCCc1nn2cc(CC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL350241 | 238716 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 426 | 8 | 1 | 7 | 4.3 | CCCCc1nn2cc(CC)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 9930953 | 202858 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 402 | 6 | 1 | 7 | 2.4 | CCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL305350 | 202858 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 402 | 6 | 1 | 7 | 2.4 | CCCc1cc(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 3025727 | 367402 | 5 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL48242 | 367402 | 5 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 3025727 | 367402 | 5 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL48242 | 367402 | 5 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44358531 | 238120 | 0 | None | None | None | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 636 | 6 | 3 | 8 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2Nc3cc(Cl)c(S(N)(=O)=O)cc3S(=O)(=O)N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL344388 | 238120 | 0 | None | None | None | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 636 | 6 | 3 | 8 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2Nc3cc(Cl)c(S(N)(=O)=O)cc3S(=O)(=O)N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 3025727 | 367402 | 5 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL48242 | 367402 | 5 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 3025727 | 367402 | 5 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL48242 | 367402 | 5 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44459759 | 199876 | 0 | None | None | None | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 568 | 7 | 2 | 8 | 5.5 | COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| CHEMBL284546 | 199876 | 0 | None | None | None | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 568 | 7 | 2 | 8 | 5.5 | COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(01)80348-6 | |||
| 15662012 | 372463 | 0 | None | None | None | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51246 | 372463 | 0 | None | None | None | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 9888865 | 120293 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 429 | 6 | 1 | 6 | 4.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(C(=O)O)(c1ccccc1)O2 | 10.1016/S0960-894X(01)80193-1 | |||
| CHEMBL165974 | 120293 | 0 | None | None | None | Rabbit | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 429 | 6 | 1 | 6 | 4.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc2c(c1)OC(C(=O)O)(c1ccccc1)O2 | 10.1016/S0960-894X(01)80193-1 | |||
| 127035084 | 273828 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 707 | 13 | 2 | 9 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735151 | 273828 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 707 | 13 | 2 | 9 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 18942290 | 386121 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 558 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc(C3=NN4CCCCC4C3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL52700 | 386121 | 0 | None | None | None | Bovine | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 558 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc(C3=NN4CCCCC4C3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 15654747 | 468814 | 0 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 5.4 | CCCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL68516 | 468814 | 0 | None | None | None | Bovine | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 5.4 | CCCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 15662012 | 372463 | 0 | None | None | None | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51246 | 372463 | 0 | None | None | None | Bovine | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2cc(C(=O)O)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 76315365 | 175902 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 535 | 11 | 3 | 8 | 4.0 | CCCCc1nnc(C(=O)NCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237580 | 175902 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 535 | 11 | 3 | 8 | 4.0 | CCCCc1nnc(C(=O)NCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10078057 | 103870 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 492 | 10 | 2 | 7 | 4.4 | CCCCc1nnc(C(=O)NCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157512 | 103870 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 492 | 10 | 2 | 7 | 4.4 | CCCCc1nnc(C(=O)NCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44358303 | 64513 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 520 | 6 | 1 | 7 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2N2N=C(c3ccccc3)N[S+]2[O-])cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL139739 | 64513 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 520 | 6 | 1 | 7 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2N2N=C(c3ccccc3)N[S+]2[O-])cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 15287887 | 291928 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 460 | 9 | 1 | 7 | 4.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2[N+](=O)[O-])cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL39124 | 291928 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 460 | 9 | 1 | 7 | 4.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2[N+](=O)[O-])cc1 | 10.1016/0960-894X(94)00476-V | |||
| 127034920 | 273966 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.7 | CCOc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736451 | 273966 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.7 | CCOc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 46910582 | 142597 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| CHEMBL1945009 | 142597 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 591 | 12 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2012.01.009 | |||
| 127036107 | 273953 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736319 | 273953 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 9940350 | 469643 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm9504722 | |||
| CHEMBL74573 | 469643 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 753 | 16 | 1 | 9 | 8.3 | CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1021/jm9504722 | |||
| 178296960 | 466470 | 0 | None | None | None | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 413 | 7 | 1 | 2 | 6.0 | CCCCC1(C)C(=O)N(Cc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc21 | 10.1021/acs.jmedchem.4c01617 | |||
| CHEMBL6146392 | 466470 | 0 | None | None | None | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 413 | 7 | 1 | 2 | 6.0 | CCCCC1(C)C(=O)N(Cc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc21 | 10.1021/acs.jmedchem.4c01617 | |||
| 10786794 | 327916 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL417366 | 327916 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10786794 | 327916 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL417366 | 327916 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 394 | 8 | 3 | 5 | 3.4 | CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 15654757 | 202316 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 494 | 7 | 2 | 7 | 4.6 | O=C(O)c1cccc2nc(OCC(F)(F)F)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1021/jm00067a016 | |||
| CHEMBL302973 | 202316 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 494 | 7 | 2 | 7 | 4.6 | O=C(O)c1cccc2nc(OCC(F)(F)F)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1021/jm00067a016 | |||
| 15654752 | 202341 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 454 | 8 | 2 | 7 | 3.8 | COCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL303170 | 202341 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 454 | 8 | 2 | 7 | 3.8 | COCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 44295010 | 370492 | 0 | None | None | None | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 4.1 | CCOC(=O)/C=C1\CC(C)(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL49262 | 370492 | 0 | None | None | None | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 4.1 | CCOC(=O)/C=C1\CC(C)(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80474-6 | |||
| 54768877 | 137420 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 535 | 9 | 1 | 8 | 5.2 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccc(CC)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL1824003 | 137420 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 535 | 9 | 1 | 8 | 5.2 | CCOC(=O)c1cn(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)nc1N(C(C)=O)c1ccc(CC)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| 178296960 | 466470 | 0 | None | None | None | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 413 | 7 | 1 | 2 | 6.0 | CCCCC1(C)C(=O)N(Cc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc21 | 10.1021/acs.jmedchem.4c01617 | |||
| CHEMBL6146392 | 466470 | 0 | None | None | None | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 413 | 7 | 1 | 2 | 6.0 | CCCCC1(C)C(=O)N(Cc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc21 | 10.1021/acs.jmedchem.4c01617 | |||
| 44315350 | 214915 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311484 | 214915 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 645 | 9 | 3 | 7 | 5.2 | CCNC(=O)Nc1ccc2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)c4ccccc4F)cc3F)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 15780089 | 199997 | 0 | None | None | None | Rabbit | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 603 | 8 | 1 | 7 | 6.4 | Cc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL285432 | 199997 | 0 | None | None | None | Rabbit | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 603 | 8 | 1 | 7 | 6.4 | Cc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 44303887 | 468349 | 0 | None | None | None | Rabbit | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 586 | 11 | 1 | 3 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Br)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL64861 | 468349 | 0 | None | None | None | Rabbit | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 586 | 11 | 1 | 3 | 6.6 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2cccc(Br)c2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 71521194 | 177688 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 423 | 4 | 2 | 6 | 3.7 | CCc1nc2cc[nH]c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322177 | 177688 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 423 | 4 | 2 | 6 | 3.7 | CCc1nc2cc[nH]c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 24828038 | 315297 | 0 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 424 | 7 | 1 | 6 | 4.5 | CCCCn1c(=O)c2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL410125 | 315297 | 0 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 424 | 7 | 1 | 6 | 4.5 | CCCCn1c(=O)c2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 19087866 | 199171 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 7 | 1 | 6 | 4.6 | CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL279515 | 199171 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 7 | 1 | 6 | 4.6 | CCCCc1nc2ccccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 14956801 | 470896 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 555 | 9 | 1 | 7 | 5.0 | CCCCc1nn(Cc2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL85765 | 470896 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 555 | 9 | 1 | 7 | 5.0 | CCCCc1nn(Cc2c(F)c(F)c(F)c(F)c2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 60165459 | 214947 | 17 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 566 | 10 | 1 | 7 | 7.7 | CCCCn1c(-c2ccc3nn(CCC)c(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)nc2ccccc21 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115247 | 214947 | 17 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 566 | 10 | 1 | 7 | 7.7 | CCCCn1c(-c2ccc3nn(CCC)c(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)c3c2)nc2ccccc21 | 10.1016/j.bmcl.2014.01.004 | |||
| 44277594 | 201913 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 619 | 8 | 1 | 9 | 5.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL30015 | 201913 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 619 | 8 | 1 | 9 | 5.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44306651 | 200694 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 533 | 3 | 1 | 4 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c(I)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL291358 | 200694 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 533 | 3 | 1 | 4 | 4.6 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(I)c(O)c(I)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 3081289 | 24326 | 7 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL115021 | 24326 | 7 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 6918269 | 198737 | 11 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL275875 | 198737 | 11 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 5.5 | CCCCc1nc2ccc(C(C)(C)OC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 19771826 | 473577 | 0 | None | None | None | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 453 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(C)=O)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL89143 | 473577 | 0 | None | None | None | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 453 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(C(C)=O)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 9895957 | 24953 | 18 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1039/C4MD00499J | |||
| CHEMBL11706 | 24953 | 18 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1039/C4MD00499J | |||
| 1610 | 7967 | 67 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| 3941 | 7967 | 67 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| 3961 | 7967 | 67 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2012.07.040 | |||
| 108185 | 3317 | 57 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00057a009 | |||
| 586 | 3317 | 57 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00057a009 | |||
| CHEMBL907 | 3317 | 57 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00057a009 | |||
| 15236334 | 330475 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 520 | 6 | 1 | 7 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NN(c3ccccc3)[S+]([O-])N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL424289 | 330475 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 520 | 6 | 1 | 7 | 5.7 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NN(c3ccccc3)[S+]([O-])N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 108185 | 3317 | 57 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00050a002 | |||
| 586 | 3317 | 57 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00050a002 | |||
| CHEMBL907 | 3317 | 57 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 2 | 6 | 4.5 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)O)Cl | 10.1021/jm00050a002 | |||
| 10394727 | 203111 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 672 | 15 | 2 | 9 | 5.4 | CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL307321 | 203111 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 672 | 15 | 2 | 9 | 5.4 | CCCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311650 | 203249 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 674 | 14 | 2 | 10 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL308361 | 203249 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 674 | 14 | 2 | 10 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CN3CCN(c4ccccn4)CC3)c2C(=O)O)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44311607 | 469112 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 517 | 9 | 3 | 8 | 4.5 | CCCc1nc(CNC(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL70770 | 469112 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 517 | 9 | 3 | 8 | 4.5 | CCCc1nc(CNC(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 15222103 | 469439 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 678 | 12 | 2 | 9 | 5.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL72819 | 469439 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 678 | 12 | 2 | 9 | 5.1 | CCCc1nc(CN2CCN(c3ccccn3)CC2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 3081289 | 24326 | 7 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL115021 | 24326 | 7 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 8 | 2 | 6 | 4.0 | CCCc1nc(CC)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 44376760 | 330276 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 532 | 11 | 3 | 6 | 4.7 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL423801 | 330276 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 532 | 11 | 3 | 6 | 4.7 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 14950498 | 199253 | 0 | None | None | None | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 461 | 7 | 1 | 6 | 5.4 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)c2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL280189 | 199253 | 0 | None | None | None | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 461 | 7 | 1 | 6 | 5.4 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)c2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| 14950505 | 199380 | 0 | None | None | None | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 433 | 6 | 1 | 5 | 5.8 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(-c2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL281192 | 199380 | 0 | None | None | None | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 433 | 6 | 1 | 5 | 5.8 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(-c2ccccc2)c(C)n1 | 10.1021/jm00061a016 | |||
| 44341922 | 24704 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 434 | 10 | 2 | 5 | 3.6 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(N)=O)C(C)C | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL116298 | 24704 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 434 | 10 | 2 | 5 | 3.6 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(N)=O)C(C)C | 10.1016/S0960-894X(01)81117-3 | |||
| 9888876 | 102235 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 429 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15606 | 102235 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 429 | 7 | 1 | 5 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2C)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 10437754 | 238434 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.6 | CCCCc1nnc(SC(C(=O)OC)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL347404 | 238434 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.6 | CCCCc1nnc(SC(C(=O)OC)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 76319527 | 176349 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 514 | 11 | 0 | 6 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2c2ccccc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2263317 | 176349 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 514 | 11 | 0 | 6 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2c2ccccc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10437754 | 238434 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.6 | CCCCc1nnc(SC(C(=O)OC)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347404 | 238434 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 12 | 2 | 8 | 5.6 | CCCCc1nnc(SC(C(=O)OC)c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10394859 | 41301 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL125760 | 41301 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 687 | 11 | 2 | 10 | 5.3 | CCOCC(=O)Nc1ccc(Cl)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 127029976 | 276543 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787767 | 276543 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 44376781 | 119076 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 517 | 10 | 2 | 6 | 4.8 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL162859 | 119076 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 517 | 10 | 2 | 6 | 4.8 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 127034922 | 273810 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.2 | CCOc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734891 | 273810 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.2 | CCOc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44274823 | 199302 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 551 | 10 | 2 | 8 | 5.8 | CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL280526 | 199302 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 551 | 10 | 2 | 8 | 5.8 | CCCCc1nc2ccc(NC(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10076191 | 237252 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 548 | 13 | 0 | 6 | 5.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC(F)(F)F)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL341151 | 237252 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 548 | 13 | 0 | 6 | 5.8 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC(F)(F)F)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277874 | 199753 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 629 | 11 | 0 | 9 | 6.9 | CCCCCN(C(=O)c1ccc(SC)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28359 | 199753 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 629 | 11 | 0 | 9 | 6.9 | CCCCCN(C(=O)c1ccc(SC)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44459903 | 199702 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 464 | 8 | 1 | 6 | 5.3 | CCCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL283292 | 199702 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 464 | 8 | 1 | 6 | 5.3 | CCCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 44277481 | 201689 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 647 | 9 | 1 | 9 | 5.8 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(C(=O)O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29853 | 201689 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 647 | 9 | 1 | 9 | 5.8 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccc(C(=O)O)cc4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 9932483 | 474712 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL9642 | 474712 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 431 | 10 | 1 | 7 | 4.1 | CCCCc1cn(CCCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)nc1 | 10.1016/j.bmc.2010.10.043 | |||
| 44358381 | 63013 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 634 | 6 | 2 | 8 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NS(=O)(=O)c3cc(S(N)(=O)=O)c(Cl)cc3N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| CHEMBL138358 | 63013 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 634 | 6 | 2 | 8 | 5.2 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2ccccc2C2=NS(=O)(=O)c3cc(S(N)(=O)=O)c(Cl)cc3N2)cc1 | 10.1016/S0960-894X(01)81119-7 | |||
| 76311802 | 175917 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 569 | 12 | 2 | 10 | 5.3 | CCCCc1nnc(SCc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237595 | 175917 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 569 | 12 | 2 | 10 | 5.3 | CCCCc1nnc(SCc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10048770 | 233134 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 10 | 2 | 5 | 3.9 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCC(C)C)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10478294 | 233134 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 10 | 2 | 5 | 3.9 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCC(C)C)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL332766 | 233134 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 10 | 2 | 5 | 3.9 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCC(C)C)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL341070 | 233134 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 10 | 2 | 5 | 3.9 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCC(C)C)n1Cc1ccc(C(=O)O)cc1 | 10.1007/s00044-009-9205-9 | |||
| 14956740 | 470617 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL83248 | 470617 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 481 | 9 | 1 | 8 | 4.3 | CCCCc1nn(-c2ccccc2OC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 9984360 | 238354 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 526 | 11 | 1 | 9 | 5.7 | CCCCc1nnc(SCc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL346542 | 238354 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 526 | 11 | 1 | 9 | 5.7 | CCCCc1nnc(SCc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44277574 | 202008 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL30086 | 202008 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 1610 | 7967 | 67 | None | None | None | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | |||
| 3941 | 7967 | 67 | None | None | None | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | |||
| 3961 | 7967 | 67 | None | None | None | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm7011563 | |||
| 10053499 | 102037 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 11 | 2 | 8 | 6.0 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL155877 | 102037 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 11 | 2 | 8 | 6.0 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10482258 | 238402 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL347135 | 238402 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44348259 | 39922 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 575 | 12 | 1 | 5 | 8.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(-c2ccccc2)c1 | 10.1021/jm00075a033 | |||
| CHEMBL122367 | 39922 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 575 | 12 | 1 | 5 | 8.4 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cccc(-c2ccccc2)c1 | 10.1021/jm00075a033 | |||
| 10053499 | 102037 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 11 | 2 | 8 | 6.0 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155877 | 102037 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 558 | 11 | 2 | 8 | 6.0 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10482258 | 238402 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL347135 | 238402 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 534 | 11 | 2 | 6 | 6.6 | CCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 71520500 | 177686 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 541 | 6 | 1 | 7 | 5.8 | CCc1nc2c(C)cn(Cc3ccccc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322175 | 177686 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 541 | 6 | 1 | 7 | 5.8 | CCc1nc2c(C)cn(Cc3ccccc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 53309274 | 136111 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 449 | 5 | 1 | 6 | 5.2 | CCc1cc(C)c2nc(CC)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| CHEMBL1801738 | 136111 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 449 | 5 | 1 | 6 | 5.2 | CCc1cc(C)c2nc(CC)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| 44277442 | 200465 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL28917 | 200465 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 583 | 10 | 0 | 8 | 6.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 132706 | 3445 | 23 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | |||
| 6896 | 3445 | 23 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL315021 | 3445 | 23 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | |||
| DB01342 | 3445 | 23 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 416 | 10 | 1 | 7 | 4.3 | CCCCc1nc(nn1Cc1ccc(nc1)c1ccccc1c1n[nH]nn1)CCCC | 10.1016/j.bmc.2010.10.043 | |||
| 10344235 | 470945 | 0 | None | None | None | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 460 | 5 | 1 | 7 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 | 10.1021/jm7011563 | |||
| CHEMBL86247 | 470945 | 0 | None | None | None | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 460 | 5 | 1 | 7 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2c(-c3nn[nH]n3)cnc3ccccc23)cc1 | 10.1021/jm7011563 | |||
| 15224471 | 310852 | 0 | None | None | None | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 441 | 8 | 2 | 7 | 4.1 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL400424 | 310852 | 0 | None | None | None | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 441 | 8 | 2 | 7 | 4.1 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 10645687 | 24471 | 0 | None | None | None | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 418 | 8 | 3 | 7 | 2.9 | CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL115946 | 24471 | 0 | None | None | None | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 418 | 8 | 3 | 7 | 2.9 | CCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 10368143 | 100028 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.8 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL153968 | 100028 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.8 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10459507 | 100986 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 525 | 11 | 2 | 7 | 5.8 | CCCCc1nnc(SCc2ccccc2C#N)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL154772 | 100986 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 525 | 11 | 2 | 7 | 5.8 | CCCCc1nnc(SCc2ccccc2C#N)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 14956775 | 468943 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 375 | 7 | 2 | 7 | 3.2 | CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL69508 | 468943 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 375 | 7 | 2 | 7 | 3.2 | CCCCc1nnc(O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 76310610 | 214946 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 542 | 10 | 1 | 5 | 8.2 | CCCCn1c(-c2ccc3nn(CCC)c(Cc4ccc(-c5ccccc5C(=O)O)cc4)c3c2)nc2ccccc21 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115246 | 214946 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 542 | 10 | 1 | 5 | 8.2 | CCCCn1c(-c2ccc3nn(CCC)c(Cc4ccc(-c5ccccc5C(=O)O)cc4)c3c2)nc2ccccc21 | 10.1016/j.bmcl.2014.01.004 | |||
| 44348332 | 39429 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCCCC2 | 10.1016/S0960-894X(01)80914-8 | |||
| CHEMBL121871 | 39429 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC12CCCCCC2 | 10.1016/S0960-894X(01)80914-8 | |||
| 44348323 | 40346 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 445 | 7 | 1 | 6 | 4.1 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(C)CC | 10.1016/S0960-894X(01)80914-8 | |||
| CHEMBL123348 | 40346 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 445 | 7 | 1 | 6 | 4.1 | CCOC(=O)/C=C1\N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)CC1(C)CC | 10.1016/S0960-894X(01)80914-8 | |||
| 10368143 | 100028 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.8 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL153968 | 100028 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 486 | 10 | 2 | 6 | 5.8 | CCCCc1nnc(Sc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10459507 | 100986 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 525 | 11 | 2 | 7 | 5.8 | CCCCc1nnc(SCc2ccccc2C#N)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154772 | 100986 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 525 | 11 | 2 | 7 | 5.8 | CCCCc1nnc(SCc2ccccc2C#N)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 19889356 | 353782 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2cccnc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| CHEMBL47459 | 353782 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 410 | 6 | 1 | 7 | 4.0 | CCCc1nc2c(C)ccnc2n1Cc1ccc(-c2cccnc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80044-X | |||
| 10642523 | 219999 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.9 | CCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL324729 | 219999 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 364 | 7 | 2 | 4 | 3.9 | CCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 9982103 | 234141 | 0 | None | None | None | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 432 | 6 | 1 | 6 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(C#N)cccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL334431 | 234141 | 0 | None | None | None | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 432 | 6 | 1 | 6 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(C#N)cccc2n1 | 10.1021/jm00100a007 | |||
| 44341924 | 25603 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 489 | 11 | 2 | 5 | 5.5 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](CC1CCCCC1)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL117941 | 25603 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 489 | 11 | 2 | 5 | 5.5 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@@H](CC1CCCCC1)C(=O)O | 10.1016/S0960-894X(01)81117-3 | |||
| 11561462 | 220650 | 51 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 449 | 10 | 1 | 6 | 4.3 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)OC)C(C)C | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL326349 | 220650 | 51 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 449 | 10 | 1 | 6 | 4.3 | CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)OC)C(C)C | 10.1016/S0960-894X(01)81117-3 | |||
| 15287885 | 317333 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 449 | 8 | 1 | 5 | 5.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2cccc(Cl)c2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL41440 | 317333 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 449 | 8 | 1 | 5 | 5.6 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2cccc(Cl)c2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 24828034 | 331251 | 0 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 510 | 8 | 1 | 9 | 3.7 | CCCCn1c(=O)c2ccc(N3CCOCC3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL427738 | 331251 | 0 | None | None | None | Rat | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 510 | 8 | 1 | 9 | 3.7 | CCCCn1c(=O)c2ccc(N3CCOCC3)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 19792191 | 198651 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 452 | 9 | 1 | 6 | 5.4 | CCCCc1nc2cccc(COC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL275304 | 198651 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 452 | 9 | 1 | 6 | 5.4 | CCCCc1nc2cccc(COC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10503729 | 23989 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 450 | 9 | 2 | 6 | 4.7 | CCCc1nc(C(C)(C)O)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL113040 | 23989 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 450 | 9 | 2 | 6 | 4.7 | CCCc1nc(C(C)(C)O)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 11741515 | 235726 | 0 | None | None | None | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 397 | 7 | 1 | 3 | 6.1 | CCCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL338048 | 235726 | 0 | None | None | None | Guinea pig | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 397 | 7 | 1 | 3 | 6.1 | CCCc1cc(OCc2ccc(-c3ccccc3C(=O)O)cc2)c2ccccc2n1 | 10.1021/jm00100a007 | |||
| 21840429 | 220438 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 393 | 9 | 2 | 5 | 3.1 | CCCCC(=O)N(CC(=O)O)Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL326140 | 220438 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 393 | 9 | 2 | 5 | 3.1 | CCCCC(=O)N(CC(=O)O)Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81117-3 | |||
| 44298570 | 201152 | 0 | None | None | None | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 452 | 7 | 1 | 7 | 4.2 | CCCOc1nc2c(C)cccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL294485 | 201152 | 0 | None | None | None | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 452 | 7 | 1 | 7 | 4.2 | CCCOc1nc2c(C)cccn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 44298809 | 390417 | 0 | None | None | None | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 452 | 6 | 1 | 7 | 4.2 | Cc1ccc2nc(OC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL55366 | 390417 | 0 | None | None | None | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 452 | 6 | 1 | 7 | 4.2 | Cc1ccc2nc(OC(C)C)c(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)n2c1 | 10.1016/S0960-894X(01)81144-6 | |||
| 19792191 | 198651 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 452 | 9 | 1 | 6 | 5.4 | CCCCc1nc2cccc(COC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL275304 | 198651 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 452 | 9 | 1 | 6 | 5.4 | CCCCc1nc2cccc(COC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 18572337 | 162598 | 9 | None | None | None | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 419 | 6 | 0 | 9 | 3.5 | O=C(Oc1coc(CSc2ncccn2)cc1=O)c1cc([N+](=O)[O-])ccc1Cl | 10.1016/j.bmcl.2012.08.105 | |||
| CHEMBL2158005 | 162598 | 9 | None | None | None | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 419 | 6 | 0 | 9 | 3.5 | O=C(Oc1coc(CSc2ncccn2)cc1=O)c1cc([N+](=O)[O-])ccc1Cl | 10.1016/j.bmcl.2012.08.105 | |||
| 127035248 | 273882 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 549 | 9 | 2 | 5 | 7.0 | CSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735653 | 273882 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 549 | 9 | 2 | 5 | 7.0 | CSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 9937461 | 201932 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 551 | 9 | 2 | 9 | 4.3 | CCCCc1nc2ccc([C@@H]3C[C@H](CO)ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL300279 | 201932 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 551 | 9 | 2 | 9 | 4.3 | CCCCc1nc2ccc([C@@H]3C[C@H](CO)ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 127035263 | 273899 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 577 | 11 | 2 | 5 | 7.8 | CCCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735804 | 273899 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 577 | 11 | 2 | 5 | 7.8 | CCCSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 15654703 | 469227 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 439 | 7 | 3 | 7 | 4.1 | CCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL71410 | 469227 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 439 | 7 | 3 | 7 | 4.1 | CCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 44305663 | 201138 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 412 | 6 | 1 | 8 | 2.7 | CCCc1cc2ncnn2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL294358 | 201138 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 412 | 6 | 1 | 8 | 2.7 | CCCc1cc2ncnn2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 19385598 | 199101 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 457 | 8 | 1 | 6 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)=O)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL278955 | 199101 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 457 | 8 | 1 | 6 | 5.1 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(C(C)=O)c1 | 10.1016/0960-894X(95)00185-V | |||
| 135723843 | 201097 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 468 | 8 | 2 | 7 | 5.5 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL294140 | 201097 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 468 | 8 | 2 | 7 | 5.5 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 15654753 | 469152 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 470 | 8 | 2 | 7 | 4.5 | CSCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL70947 | 469152 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 470 | 8 | 2 | 7 | 4.5 | CSCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 127035393 | 273836 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 587 | 10 | 2 | 7 | 6.9 | CCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735227 | 273836 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 587 | 10 | 2 | 7 | 6.9 | CCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 76315369 | 175931 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 522 | 12 | 2 | 8 | 4.7 | CCCCc1nnc(OCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237609 | 175931 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 522 | 12 | 2 | 8 | 4.7 | CCCCc1nnc(OCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10005344 | 100439 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 479 | 11 | 1 | 7 | 5.1 | CCCCc1nnc(OCCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154315 | 100439 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 479 | 11 | 1 | 7 | 5.1 | CCCCc1nnc(OCCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 71521585 | 177685 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 532 | 6 | 1 | 9 | 4.8 | CCc1nc2ccn(Cc3c(C)noc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322174 | 177685 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 532 | 6 | 1 | 9 | 4.8 | CCc1nc2ccn(Cc3c(C)noc3C)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 71521505 | 177711 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 514 | 6 | 1 | 8 | 4.6 | CCc1nc2ccn(Cc3ccccn3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322451 | 177711 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 514 | 6 | 1 | 8 | 4.6 | CCc1nc2ccn(Cc3ccccn3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 70684421 | 158285 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1c(Cl)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063980 | 158285 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1c(Cl)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 9979266 | 236141 | 0 | None | None | None | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 379 | 5 | 1 | 5 | 4.7 | c1ccc(-c2nn[nH]n2)c(-c2ccc(COc3ccnc4ccccc34)cc2)c1 | 10.1021/jm00100a007 | |||
| CHEMBL339592 | 236141 | 0 | None | None | None | Guinea pig | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 379 | 5 | 1 | 5 | 4.7 | c1ccc(-c2nn[nH]n2)c(-c2ccc(COc3ccnc4ccccc34)cc2)c1 | 10.1021/jm00100a007 | |||
| 70684421 | 158285 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1c(Cl)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| CHEMBL2063980 | 158285 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1c(Cl)nc(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.07.040 | |||
| 71654380 | 180014 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 657 | 12 | 3 | 8 | 6.1 | CCCCc1c(Cl)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2366021 | 180014 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 657 | 12 | 3 | 8 | 6.1 | CCCCc1c(Cl)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 44315344 | 214782 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL311386 | 214782 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 665 | 12 | 2 | 8 | 5.2 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)COCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 19036230 | 201866 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 408 | 9 | 3 | 5 | 3.8 | CCCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL299809 | 201866 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 408 | 9 | 3 | 5 | 3.8 | CCCCc1nc(CO)c(C(=O)O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 15287883 | 198496 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 415 | 8 | 1 | 5 | 4.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL274260 | 198496 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 415 | 8 | 1 | 5 | 4.9 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 15654760 | 202282 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 467 | 9 | 3 | 7 | 4.8 | CCCCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL302811 | 202282 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 467 | 9 | 3 | 7 | 4.8 | CCCCNc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 9983514 | 43331 | 0 | None | None | None | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 465 | 7 | 1 | 7 | 5.0 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(=O)OC)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL129872 | 43331 | 0 | None | None | None | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 465 | 7 | 1 | 7 | 5.0 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(=O)OC)ccc2n1 | 10.1021/jm00100a007 | |||
| 15654696 | 213502 | 50 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 454 | 7 | 1 | 8 | 4.1 | CCOc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL308884 | 213502 | 50 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 454 | 7 | 1 | 8 | 4.1 | CCOc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 44295673 | 318259 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 428 | 8 | 2 | 4 | 5.5 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL417196 | 318259 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 428 | 8 | 2 | 4 | 5.5 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| 44295673 | 318259 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 428 | 8 | 2 | 4 | 5.5 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL417196 | 318259 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 428 | 8 | 2 | 4 | 5.5 | CCCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1007/s00044-009-9182-z | |||
| 44305289 | 468308 | 0 | None | None | None | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 416 | 6 | 1 | 7 | 2.7 | CCCc1c(C)c(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL64670 | 468308 | 0 | None | None | None | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 416 | 6 | 1 | 7 | 2.7 | CCCc1c(C)c(=O)n(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 18654313 | 135848 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 435 | 4 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1[C@@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801713 | 135848 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 435 | 4 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1[C@@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 15171411 | 473187 | 0 | None | None | None | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 5.0 | CCc1cc(OCc2ccc(-c3cc(OC)ccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL86495 | 473187 | 0 | None | None | None | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 5.0 | CCc1cc(OCc2ccc(-c3cc(OC)ccc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 71521419 | 177707 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 531 | 6 | 1 | 7 | 5.3 | CCc1nc2ccn(Cc3cccc(F)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322448 | 177707 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 531 | 6 | 1 | 7 | 5.3 | CCc1nc2ccn(Cc3cccc(F)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 127026041 | 274933 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 605 | 11 | 3 | 8 | 5.0 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3754267 | 274933 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 605 | 11 | 3 | 8 | 5.0 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 127035381 | 273912 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 573 | 9 | 2 | 7 | 6.5 | CSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735940 | 273912 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 573 | 9 | 2 | 7 | 6.5 | CSc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 14956800 | 470935 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL86143 | 470935 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 509 | 10 | 2 | 8 | 4.0 | CCCCc1nn(C(C(=O)O)c2ccccc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 22850890 | 365967 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 577 | 8 | 1 | 10 | 4.1 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)OC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL51606 | 365967 | 0 | None | None | None | Bovine | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 577 | 8 | 1 | 10 | 4.1 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)OC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 44294562 | 372300 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL51078 | 372300 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 44563175 | 372251 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 570 | 7 | 1 | 5 | 8.6 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncc(Cl)[nH]2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| CHEMBL510065 | 372251 | 0 | None | None | None | Bovine | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 570 | 7 | 1 | 5 | 8.6 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2-c2ncc(Cl)[nH]2)cc1 | 10.1016/j.bmc.2008.10.040 | |||
| 14956746 | 473179 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL86440 | 473179 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 485 | 8 | 1 | 7 | 4.9 | CCCCc1nn(-c2ccc(Cl)cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44270285 | 199292 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 415 | 7 | 1 | 5 | 4.7 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL280456 | 199292 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 415 | 7 | 1 | 5 | 4.7 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 127026040 | 274882 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 591 | 11 | 3 | 8 | 4.6 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3753888 | 274882 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 591 | 11 | 3 | 8 | 4.6 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 44298833 | 408697 | 0 | None | None | None | Bovine | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 482 | 7 | 2 | 8 | 3.6 | CC(C)Oc1nc2ccc(C(=O)O)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| CHEMBL57781 | 408697 | 0 | None | None | None | Bovine | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 482 | 7 | 2 | 8 | 3.6 | CC(C)Oc1nc2ccc(C(=O)O)cn2c(=O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81144-6 | |||
| 127035249 | 273958 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 573 | 9 | 2 | 7 | 6.5 | CSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736346 | 273958 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 573 | 9 | 2 | 7 | 6.5 | CSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44274733 | 199611 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 482 | 8 | 1 | 7 | 5.4 | CCCCc1nc2ccc(SC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL282746 | 199611 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 482 | 8 | 1 | 7 | 5.4 | CCCCc1nc2ccc(SC)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 15171415 | 216594 | 0 | None | None | None | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 445 | 6 | 1 | 5 | 5.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(Cl)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL314859 | 216594 | 0 | None | None | None | Guinea pig | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 445 | 6 | 1 | 5 | 5.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(Cl)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 127035757 | 273942 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 591 | 10 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736242 | 273942 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 591 | 10 | 1 | 8 | 6.2 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 71520501 | 177687 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 552 | 6 | 1 | 8 | 5.4 | CCc1nc2c(C)cn(Cc3ccccc3C#N)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322176 | 177687 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 552 | 6 | 1 | 8 | 5.4 | CCc1nc2c(C)cn(Cc3ccccc3C#N)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 44376991 | 238964 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 1 | 7 | 4.3 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL352675 | 238964 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 436 | 8 | 1 | 7 | 4.3 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-n2cnnn2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10075750 | 217193 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 532 | 10 | 1 | 7 | 4.8 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL318891 | 217193 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 532 | 10 | 1 | 7 | 4.8 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm00043a020 | |||
| 9851889 | 202170 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL302102 | 202170 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 611 | 12 | 1 | 7 | 7.1 | CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/0960-894X(94)85036-4 | |||
| 19010079 | 175910 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 524 | 11 | 2 | 8 | 5.4 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237588 | 175910 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 524 | 11 | 2 | 8 | 5.4 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10026681 | 41806 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 448 | 10 | 2 | 7 | 3.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| 9981102 | 41806 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 448 | 10 | 2 | 7 | 3.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125940 | 41806 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 448 | 10 | 2 | 7 | 3.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL421074 | 41806 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 448 | 10 | 2 | 7 | 3.1 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10367792 | 41808 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 478 | 9 | 1 | 7 | 4.2 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125958 | 41808 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 478 | 9 | 1 | 7 | 4.2 | CCCCc1ncc(/C=C2/C(=O)NC(=O)N2Cc2cccs2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10096735 | 238277 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 481 | 10 | 1 | 7 | 5.8 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345717 | 238277 | 0 | None | None | None | Rabbit | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 481 | 10 | 1 | 7 | 5.8 | CCCCc1nnc(SCc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44277873 | 199111 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 661 | 11 | 0 | 10 | 5.5 | CCCCCN(C(=O)c1ccc(S(C)(=O)=O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL27903 | 199111 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 661 | 11 | 0 | 10 | 5.5 | CCCCCN(C(=O)c1ccc(S(C)(=O)=O)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 44314780 | 203127 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL307430 | 203127 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 649 | 11 | 3 | 8 | 5.6 | CCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 127034921 | 273963 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.7 | CCOc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736440 | 273963 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 547 | 10 | 2 | 5 | 6.7 | CCOc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 1037 | 7928 | 51 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 3940 | 7928 | 51 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 5281037 | 7928 | 51 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| CHEMBL813 | 7928 | 51 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 10.1016/S0960-894X(01)81116-1 | |||
| 11757193 | 104582 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 546 | 12 | 2 | 7 | 4.9 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL158133 | 104582 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 546 | 12 | 2 | 7 | 4.9 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 24755620 | 8610 | 72 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acs.jmedchem.1c00123 | |||
| 2806 | 8610 | 72 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acs.jmedchem.1c00123 | |||
| 3937 | 8610 | 72 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acs.jmedchem.1c00123 | |||
| 5284633 | 8610 | 72 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acs.jmedchem.1c00123 | |||
| 60846 | 8610 | 72 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acs.jmedchem.1c00123 | |||
| CHEMBL1069 | 8610 | 72 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acs.jmedchem.1c00123 | |||
| CHEMBL115622 | 8610 | 72 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acs.jmedchem.1c00123 | |||
| CHEMBL5315276 | 8610 | 72 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acs.jmedchem.1c00123 | |||
| DB00177 | 8610 | 72 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/acs.jmedchem.1c00123 | |||
| 11757193 | 104582 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 546 | 12 | 2 | 7 | 4.9 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL158133 | 104582 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 546 | 12 | 2 | 7 | 4.9 | CCCCc1nnc([S+]([O-])Cc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44379269 | 119966 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 644 | 12 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL164769 | 119966 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 644 | 12 | 1 | 8 | 5.9 | CCCCc1nc2ccc(N(C)C(=O)OCC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 44376779 | 119302 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 496 | 11 | 3 | 6 | 3.8 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL163485 | 119302 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 496 | 11 | 3 | 6 | 3.8 | CCCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2NS(=O)(=O)NC(=O)C2CC2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 44277549 | 199352 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 594 | 8 | 0 | 10 | 5.1 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccco4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL280988 | 199352 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 594 | 8 | 0 | 10 | 5.1 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccco4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44300637 | 201067 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 600 | 11 | 1 | 7 | 7.2 | CCCCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL293949 | 201067 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 600 | 11 | 1 | 7 | 7.2 | CCCCCc1cc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)c2ccccc2)s1 | 10.1016/S0960-894X(01)81145-8 | |||
| 10436523 | 238218 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccc(C)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL345139 | 238218 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccc(C)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10436523 | 238218 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccc(C)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345139 | 238218 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 11 | 2 | 6 | 6.2 | CCCCc1nnc(SCc2ccc(C)cc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 44274716 | 197194 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 8 | 1 | 8 | 4.0 | CCCCc1nc2ccc(S(C)(=O)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL26548 | 197194 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 514 | 8 | 1 | 8 | 4.0 | CCCCc1nc2ccc(S(C)(=O)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 54178446 | 135847 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 4 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801712 | 135847 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 4 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 14956755 | 215829 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccccc2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL313579 | 215829 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 469 | 8 | 1 | 7 | 4.4 | CCCCc1nn(-c2ccccc2F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 10202093 | 473402 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 8 | 1 | 7 | 3.9 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87985 | 473402 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 8 | 1 | 7 | 3.9 | CCCCc1nn(C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 158781 | 97454 | 64 | None | None | None | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1516 | 97454 | 64 | None | None | None | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| DB00275 | 97454 | 64 | None | None | None | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 10048120 | 238243 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 426 | 7 | 1 | 7 | 4.4 | CCCCc1nn2c(C)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345404 | 238243 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 426 | 7 | 1 | 7 | 4.4 | CCCCc1nn2c(C)c(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10346399 | 100848 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 514 | 12 | 2 | 6 | 6.0 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL154640 | 100848 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 514 | 12 | 2 | 6 | 6.0 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 11758329 | 235789 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 603 | 12 | 0 | 8 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC(F)(F)F)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL338431 | 235789 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 603 | 12 | 0 | 8 | 6.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC(F)(F)F)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 14956776 | 215653 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 389 | 7 | 1 | 7 | 2.8 | CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL313017 | 215653 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 389 | 7 | 1 | 7 | 2.8 | CCCCc1nn(C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 10346399 | 100848 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 514 | 12 | 2 | 6 | 6.0 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154640 | 100848 | 0 | None | None | None | Rabbit | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 514 | 12 | 2 | 6 | 6.0 | CCCCc1nnc(SCCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 24828705 | 313592 | 0 | None | None | None | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 443 | 7 | 1 | 7 | 4.0 | CCCCn1c(=O)c2cc(F)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL408188 | 313592 | 0 | None | None | None | Rat | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 443 | 7 | 1 | 7 | 4.0 | CCCCn1c(=O)c2cc(F)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 127036108 | 273823 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735098 | 273823 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10368898 | 42756 | 0 | None | None | None | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 469 | 9 | 1 | 6 | 5.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OCCF)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL128389 | 42756 | 0 | None | None | None | Guinea pig | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 469 | 9 | 1 | 6 | 5.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OCCF)ccc2n1 | 10.1021/jm00100a007 | |||
| 44274706 | 197079 | 0 | None | None | None | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 518 | 8 | 2 | 6 | 5.5 | CCCCc1nc2cc(C3=NN(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)C(=O)CC3C)ccc2[nH]1 | 10.1016/S0960-894X(01)80348-6 | |||
| CHEMBL26449 | 197079 | 0 | None | None | None | Bovine | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 518 | 8 | 2 | 6 | 5.5 | CCCCc1nc2cc(C3=NN(Cc4ccc(-c5ccccc5-c5nn[nH]n5)cc4)C(=O)CC3C)ccc2[nH]1 | 10.1016/S0960-894X(01)80348-6 | |||
| 42611190 | 6416 | 21 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL4507292 | |||
| 5802 | 6416 | 21 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL4507292 | |||
| CHEMBL1800685 | 6416 | 21 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL4507292 | |||
| 71653750 | 180008 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 671 | 11 | 2 | 7 | 6.7 | CCCCc1c(Br)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2365906 | 180008 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 671 | 11 | 2 | 7 | 6.7 | CCCCc1c(Br)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 76329881 | 175907 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 490 | 11 | 2 | 8 | 4.9 | CCCCc1nnc(SCC(C)C)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237585 | 175907 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 490 | 11 | 2 | 8 | 4.9 | CCCCc1nnc(SCC(C)C)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 15780085 | 236974 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 617 | 9 | 1 | 7 | 6.7 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL34082 | 236974 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 617 | 9 | 1 | 7 | 6.7 | CCc1nc2ccc(N(Cc3ccccc3)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 9981071 | 238221 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 447 | 10 | 1 | 7 | 5.3 | CCCCc1nnc(SCC(C)C)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345181 | 238221 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 447 | 10 | 1 | 7 | 5.3 | CCCCc1nnc(SCC(C)C)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10345129 | 102361 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 481 | 11 | 3 | 7 | 3.5 | CCCCc1nnc(SCC(=O)NC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL156181 | 102361 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 481 | 11 | 3 | 7 | 3.5 | CCCCc1nnc(SCC(=O)NC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10345129 | 102361 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 481 | 11 | 3 | 7 | 3.5 | CCCCc1nnc(SCC(=O)NC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156181 | 102361 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 481 | 11 | 3 | 7 | 3.5 | CCCCc1nnc(SCC(=O)NC)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 19792156 | 373096 | 0 | None | None | None | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2c(C(=O)OC)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51712 | 373096 | 0 | None | None | None | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2c(C(=O)OC)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792156 | 373096 | 0 | None | None | None | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2c(C(=O)OC)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51712 | 373096 | 0 | None | None | None | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2c(C(=O)OC)cccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 71611145 | 368171 | 2 | None | None | None | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 1072 | 29 | 14 | 13 | -0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| CHEMBL4852514 | 368171 | 2 | None | None | None | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 1072 | 29 | 14 | 13 | -0.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2021.128086 | |||
| 127036866 | 274674 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 614 | 11 | 3 | 8 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752117 | 274674 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 614 | 11 | 3 | 8 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 127028930 | 274708 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 570 | 9 | 3 | 7 | 6.0 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752444 | 274708 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 570 | 9 | 3 | 7 | 6.0 | CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 127034904 | 273902 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 561 | 10 | 2 | 4 | 7.8 | CCCc1nc2c(C)cc(C(=S)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735831 | 273902 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 561 | 10 | 2 | 4 | 7.8 | CCCc1nc2c(C)cc(C(=S)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 15069406 | 201860 | 0 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cc(C(=O)OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299753 | 201860 | 0 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cc(C(=O)OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 15069406 | 201860 | 0 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cc(C(=O)OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL299753 | 201860 | 0 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 8 | 1 | 7 | 5.1 | CCCCc1nc2cc(C(=O)OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 53309405 | 136115 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(CC(C)C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801742 | 136115 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(CC(C)C)cc(C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 10323718 | 238274 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.6 | CCCSc1nnc(CCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL345696 | 238274 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.6 | CCCSc1nnc(CCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10323718 | 238274 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.6 | CCCSc1nnc(CCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL345696 | 238274 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 500 | 11 | 2 | 6 | 5.6 | CCCSc1nnc(CCc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 176251361 | 465872 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 368 | 5 | 1 | 5 | 2.9 | CCCCC(=O)N1CCCC2(CCN(c3ccccc3-c3nnn[nH]3)C2)C1 | 10.1021/acs.jmedchem.4c01617 | |||
| CHEMBL6103112 | 465872 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 368 | 5 | 1 | 5 | 2.9 | CCCCC(=O)N1CCCC2(CCN(c3ccccc3-c3nnn[nH]3)C2)C1 | 10.1021/acs.jmedchem.4c01617 | |||
| 176251361 | 465872 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 368 | 5 | 1 | 5 | 2.9 | CCCCC(=O)N1CCCC2(CCN(c3ccccc3-c3nnn[nH]3)C2)C1 | 10.1021/acs.jmedchem.4c01617 | |||
| CHEMBL6103112 | 465872 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 368 | 5 | 1 | 5 | 2.9 | CCCCC(=O)N1CCCC2(CCN(c3ccccc3-c3nnn[nH]3)C2)C1 | 10.1021/acs.jmedchem.4c01617 | |||
| 127035380 | 273961 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736414 | 273961 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 691 | 13 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 24827904 | 196778 | 0 | None | None | None | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 459 | 7 | 1 | 7 | 4.5 | CCCCn1c(=O)c2cc(Cl)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL262098 | 196778 | 0 | None | None | None | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 459 | 7 | 1 | 7 | 4.5 | CCCCn1c(=O)c2cc(Cl)cnc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 44297202 | 201862 | 0 | None | None | None | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 623 | 9 | 1 | 9 | 6.5 | CCCCc1nc2ccc([C@@H]3C[C@H]4C(c5ccccc5)=NO[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL299770 | 201862 | 0 | None | None | None | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 623 | 9 | 1 | 9 | 6.5 | CCCCc1nc2ccc([C@@H]3C[C@H]4C(c5ccccc5)=NO[C@H]4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 44292497 | 38681 | 0 | None | None | None | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@@]3(C)C[C@@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| CHEMBL1206677 | 38681 | 0 | None | None | None | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.6 | CCCCc1nc2ccc([C@@]3(C)C[C@@H]4CCCN4O3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/S0960-894X(00)80366-2 | |||
| 44287133 | 275006 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(c2ccccc2)c2nnn[nH]2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL37565 | 275006 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 439 | 8 | 1 | 7 | 4.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(c2ccccc2)c2nnn[nH]2)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 10457332 | 104654 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 468 | 11 | 3 | 7 | 3.8 | CCCCc1nnc(SCC(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL158196 | 104654 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 468 | 11 | 3 | 7 | 3.8 | CCCCc1nnc(SCC(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10457332 | 104654 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 468 | 11 | 3 | 7 | 3.8 | CCCCc1nnc(SCC(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL158196 | 104654 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 468 | 11 | 3 | 7 | 3.8 | CCCCc1nnc(SCC(=O)O)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 46910581 | 157992 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 615 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058863 | 157992 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 615 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 10416836 | 217530 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 651 | 11 | 1 | 8 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL319313 | 217530 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 651 | 11 | 1 | 8 | 6.8 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc([N+](=O)[O-])cc2)cc1 | 10.1021/jm00043a020 | |||
| 70690562 | 157985 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058856 | 157985 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 571 | 10 | 2 | 7 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 76319036 | 175934 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 537 | 12 | 3 | 9 | 4.7 | CCCCc1nnc(NCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237612 | 175934 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 537 | 12 | 3 | 9 | 4.7 | CCCCc1nnc(NCc2ccc(OC)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 44307107 | 198948 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 417 | 4 | 1 | 6 | 3.9 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)c(O)c(C(=O)OC)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL277614 | 198948 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 417 | 4 | 1 | 6 | 3.9 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)c(O)c(C(=O)OC)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 10435850 | 101861 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 494 | 11 | 2 | 8 | 5.1 | CCCCc1nnc(NCc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL155724 | 101861 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 494 | 11 | 2 | 8 | 5.1 | CCCCc1nnc(NCc2ccc(OC)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 127035391 | 273855 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 563 | 10 | 2 | 5 | 7.4 | CCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735390 | 273855 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 563 | 10 | 2 | 5 | 7.4 | CCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 14956774 | 473219 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 452 | 8 | 1 | 8 | 3.7 | CCCCc1nn(-c2ccccn2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL86741 | 473219 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 452 | 8 | 1 | 8 | 3.7 | CCCCc1nn(-c2ccccn2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 15780095 | 198853 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 595 | 9 | 1 | 7 | 6.5 | CCc1nc2ccc(N(CC=C(C)C)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL276853 | 198853 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 595 | 9 | 1 | 7 | 6.5 | CCc1nc2ccc(N(CC=C(C)C)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 44297217 | 201687 | 0 | None | None | None | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 651 | 10 | 1 | 9 | 6.5 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL298509 | 201687 | 0 | None | None | None | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 651 | 10 | 1 | 9 | 6.5 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 135723817 | 200914 | 0 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 470 | 8 | 2 | 8 | 5.0 | CCCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL292914 | 200914 | 0 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 470 | 8 | 2 | 8 | 5.0 | CCCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 176251289 | 466651 | 0 | None | None | None | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 374 | 4 | 1 | 6 | 4.1 | CCc1cnc(N2Cc3ccc(-c4ccccc4-c4nnn[nH]4)cc3C2)s1 | 10.1021/acs.jmedchem.4c01617 | |||
| CHEMBL6151073 | 466651 | 0 | None | None | None | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 374 | 4 | 1 | 6 | 4.1 | CCc1cnc(N2Cc3ccc(-c4ccccc4-c4nnn[nH]4)cc3C2)s1 | 10.1021/acs.jmedchem.4c01617 | |||
| 44274692 | 196787 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 541 | 10 | 2 | 7 | 6.2 | CCCCc1nc2ccc(NCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL26217 | 196787 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 541 | 10 | 2 | 7 | 6.2 | CCCCc1nc2ccc(NCc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10324870 | 232362 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 535 | 12 | 0 | 8 | 5.1 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cscn2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL331546 | 232362 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 535 | 12 | 0 | 8 | 5.1 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cscn2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 11758341 | 236133 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 603 | 13 | 1 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C2(C(=O)O)CCCC2)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL339544 | 236133 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 603 | 13 | 1 | 7 | 6.5 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C2(C(=O)O)CCCC2)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44306652 | 468366 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 437 | 3 | 1 | 4 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL64983 | 468366 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 437 | 3 | 1 | 4 | 4.9 | CCc1nc2c(C)cc(C)nc2n1Cc1cc(Br)c(O)c(Br)c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 44311584 | 202837 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 695 | 16 | 1 | 8 | 8.1 | CCCCN(Cc1ccccc1)C(=O)c1ccc(COC(=O)c2c(CC)nc(CCC)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL305239 | 202837 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 695 | 16 | 1 | 8 | 8.1 | CCCCN(Cc1ccccc1)C(=O)c1ccc(COC(=O)c2c(CC)nc(CCC)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 19771800 | 473348 | 0 | None | None | None | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 5.0 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(OC)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL87603 | 473348 | 0 | None | None | None | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 5.0 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)c(OC)c2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 20747575 | 198694 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 579 | 12 | 2 | 8 | 5.0 | CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COC)c1 | 10.1039/C4MD00499J | |||
| CHEMBL275545 | 198694 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 579 | 12 | 2 | 8 | 5.0 | CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COC)c1 | 10.1039/C4MD00499J | |||
| 127035085 | 273874 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 661 | 12 | 2 | 7 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735574 | 273874 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 661 | 12 | 2 | 7 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 44285327 | 333268 | 0 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 430 | 6 | 1 | 6 | 3.6 | CCCC1=NC2(CCOCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL435953 | 333268 | 0 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 430 | 6 | 1 | 6 | 3.6 | CCCC1=NC2(CCOCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 44311496 | 469168 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 722 | 15 | 2 | 8 | 7.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL71069 | 469168 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 722 | 15 | 2 | 8 | 7.2 | CCCc1nc(CN(Cc2ccccc2)C(=O)c2ccccc2)c(C(=O)O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCC(C)C)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 44379350 | 239414 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 599 | 10 | 1 | 7 | 6.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| CHEMBL355443 | 239414 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 599 | 10 | 1 | 7 | 6.8 | CCCCc1nc2ccc(C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2cccs2)cc1 | 10.1016/S0960-894X(01)81125-2 | |||
| 9843950 | 200722 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 400 | 8 | 1 | 6 | 4.1 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL291582 | 200722 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 400 | 8 | 1 | 6 | 4.1 | CCCc1nc(CC)c(C=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 14950510 | 176628 | 0 | None | None | None | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 413 | 7 | 1 | 6 | 4.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(C)=O)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL22879 | 176628 | 0 | None | None | None | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 413 | 7 | 1 | 6 | 4.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(C)=O)c(C)n1 | 10.1021/jm00061a016 | |||
| 15171369 | 199666 | 0 | None | None | None | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 397 | 6 | 1 | 5 | 4.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCC2 | 10.1021/jm00061a016 | |||
| CHEMBL283110 | 199666 | 0 | None | None | None | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 397 | 6 | 1 | 5 | 4.6 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(n1)CCC2 | 10.1021/jm00061a016 | |||
| 1610 | 7967 | 67 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81117-3 | |||
| 3941 | 7967 | 67 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81117-3 | |||
| 3961 | 7967 | 67 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81117-3 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81117-3 | |||
| 19385601 | 105147 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 491 | 9 | 1 | 5 | 6.5 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1Cl | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15860 | 105147 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 491 | 9 | 1 | 5 | 6.5 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1Cl | 10.1016/0960-894X(95)00185-V | |||
| 158781 | 97454 | 64 | None | None | None | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1516 | 97454 | 64 | None | None | None | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| DB00275 | 97454 | 64 | None | None | None | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 158781 | 97454 | 64 | None | None | None | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/jm950450f | |||
| CHEMBL1516 | 97454 | 64 | None | None | None | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/jm950450f | |||
| DB00275 | 97454 | 64 | None | None | None | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 446 | 8 | 3 | 7 | 3.7 | CCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/jm950450f | |||
| 9874508 | 469570 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL73876 | 469570 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 663 | 11 | 2 | 8 | 5.9 | CCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC2CC2)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 10223724 | 470571 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL82797 | 470571 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 417 | 9 | 1 | 7 | 3.7 | CCCCc1nn(CCC)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 53309271 | 136108 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 447 | 4 | 1 | 6 | 5.3 | Cc1cc(C)c2nc(C3CC3)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| CHEMBL1801735 | 136108 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 447 | 4 | 1 | 6 | 5.3 | Cc1cc(C)c2nc(C3CC3)n([C@H]3CCc4cc(-c5ccccc5-c5nnn[nH]5)ccc43)c2n1 | 10.1021/jm200409s | |||
| 10414273 | 233554 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 518 | 12 | 0 | 7 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccoc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL333722 | 233554 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 518 | 12 | 0 | 7 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccoc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277872 | 196902 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 689 | 13 | 0 | 9 | 7.7 | CCCCCN(C(=O)c1ccc(OCc2ccccc2)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL263038 | 196902 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 689 | 13 | 0 | 9 | 7.7 | CCCCCN(C(=O)c1ccc(OCc2ccccc2)cc1)c1ccc2ncn(Cc3ccc(-c4ccccc4-c4nnnn4C)cc3)c(=O)c2c1 | 10.1016/0960-894X(95)00224-H | |||
| 10256564 | 40155 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 533 | 12 | 0 | 8 | 5.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(C)on2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL122458 | 40155 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 533 | 12 | 0 | 8 | 5.0 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2cc(C)on2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10391038 | 235805 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 494 | 13 | 0 | 6 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL338514 | 235805 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 494 | 13 | 0 | 6 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2CCCC)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 70694737 | 157876 | 0 | None | None | None | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 544 | 10 | 1 | 7 | 6.5 | CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058372 | 157876 | 0 | None | None | None | Bovine | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 544 | 10 | 1 | 7 | 6.5 | CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 44376822 | 238743 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 565 | 10 | 1 | 7 | 5.5 | CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| CHEMBL350493 | 238743 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 565 | 10 | 1 | 7 | 5.5 | CCCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81124-0 | |||
| 10439858 | 40743 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| CHEMBL124903 | 40743 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 719 | 11 | 2 | 9 | 6.2 | CCCCNC(=O)c1ccc(C(F)(F)F)c(-n2nc(CC)n(Cc3ccc(-c4ccccc4S(=O)(=O)NC(=O)OC(C)(C)C)cc3F)c2=O)c1 | 10.1021/jm00019a004 | |||
| 44384872 | 122771 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 575 | 9 | 3 | 7 | 4.4 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| CHEMBL173455 | 122771 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 575 | 9 | 3 | 7 | 4.4 | CCCc1nc2ccc(NC(=O)NC(C)C)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)=O)cc1 | 10.1016/0960-894X(96)00116-3 | |||
| 76322692 | 175927 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 585 | 12 | 2 | 10 | 4.3 | CCCCc1nnc([S+]([O-])Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237605 | 175927 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 585 | 12 | 2 | 10 | 4.3 | CCCCc1nnc([S+]([O-])Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10392565 | 333107 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 542 | 11 | 1 | 9 | 4.7 | CCCCc1nnc([S+]([O-])Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL434844 | 333107 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 542 | 11 | 1 | 9 | 4.7 | CCCCc1nnc([S+]([O-])Cc2ccc([N+](=O)[O-])cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44274824 | 199478 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 535 | 11 | 2 | 7 | 5.8 | CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL281846 | 199478 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 535 | 11 | 2 | 7 | 5.8 | CCCCC(=O)Nc1ccc2nc(CCCC)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| 14956747 | 470772 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL84630 | 470772 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccc([N+](=O)[O-])cc2)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 15287893 | 317454 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 515 | 14 | 1 | 6 | 6.9 | CCCCCCOc1ccccc1C(Oc1ccc(Cn2c(CCC)nc3c(C)ccnc32)cc1)C(=O)O | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL41566 | 317454 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 515 | 14 | 1 | 6 | 6.9 | CCCCCCOc1ccccc1C(Oc1ccc(Cn2c(CCC)nc3c(C)ccnc32)cc1)C(=O)O | 10.1016/0960-894X(94)00476-V | |||
| 15654754 | 202174 | 0 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 439 | 7 | 3 | 7 | 3.3 | CNCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL302127 | 202174 | 0 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 439 | 7 | 3 | 7 | 3.3 | CNCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 127035083 | 273803 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 677 | 12 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3734835 | 273803 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 677 | 12 | 2 | 8 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 24827901 | 315271 | 0 | None | None | None | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 439 | 7 | 1 | 7 | 4.2 | CCCCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL410105 | 315271 | 0 | None | None | None | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 439 | 7 | 1 | 7 | 4.2 | CCCCn1c(=O)c2ccc(C)nc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 71521504 | 177710 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 581 | 6 | 1 | 7 | 6.2 | CCc1nc2ccn(Cc3cccc(C(F)(F)F)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322450 | 177710 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 581 | 6 | 1 | 7 | 6.2 | CCc1nc2ccn(Cc3cccc(C(F)(F)F)c3)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 44309398 | 202351 | 0 | None | None | None | Bovine | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 546 | 6 | 1 | 3 | 5.5 | CCCCc1nc2ccccc2n1CCc1cc(I)c(O)c(I)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL303247 | 202351 | 0 | None | None | None | Bovine | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 546 | 6 | 1 | 3 | 5.5 | CCCCc1nc2ccccc2n1CCc1cc(I)c(O)c(I)c1 | 10.1016/S0960-894X(01)81149-5 | |||
| 127036865 | 274827 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 584 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3753406 | 274827 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 584 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 15654743 | 332879 | 0 | None | None | None | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 438 | 6 | 2 | 6 | 4.8 | CC(C)c1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL433099 | 332879 | 0 | None | None | None | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 438 | 6 | 2 | 6 | 4.8 | CC(C)c1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 44283175 | 239027 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 637 | 8 | 1 | 7 | 7.1 | Cc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| CHEMBL35324 | 239027 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 637 | 8 | 1 | 7 | 7.1 | Cc1nc2ccc(N(Cc3ccccc3Cl)C(=O)c3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80517-5 | |||
| 10028815 | 474942 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 496 | 8 | 1 | 6 | 4.4 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1 | 10.1021/jm00043a020 | |||
| CHEMBL97783 | 474942 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 496 | 8 | 1 | 6 | 4.4 | CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(N)(=O)=O)cc1 | 10.1021/jm00043a020 | |||
| 44310590 | 469282 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 4.9 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| CHEMBL71730 | 469282 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 385 | 5 | 1 | 4 | 4.9 | CCc1nc2c(C)cc(C)nn2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81150-1 | |||
| 71653748 | 180007 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 627 | 11 | 2 | 7 | 6.6 | CCCCc1c(Cl)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| CHEMBL2365905 | 180007 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 627 | 11 | 2 | 7 | 6.6 | CCCCc1c(Cl)[n+](Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cn1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2012.12.044 | |||
| 15654744 | 202239 | 0 | None | None | None | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 436 | 6 | 2 | 6 | 4.5 | O=C(O)c1cccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1021/jm00067a016 | |||
| CHEMBL302520 | 202239 | 0 | None | None | None | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 436 | 6 | 2 | 6 | 4.5 | O=C(O)c1cccc2nc(C3CC3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c12 | 10.1021/jm00067a016 | |||
| 10502342 | 333693 | 0 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 422 | 9 | 2 | 6 | 3.9 | CCCc1nc(CO)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| CHEMBL439743 | 333693 | 0 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 422 | 9 | 2 | 6 | 3.9 | CCCc1nc(CO)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm950450f | |||
| 10502342 | 333693 | 0 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 422 | 9 | 2 | 6 | 3.9 | CCCc1nc(CO)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| CHEMBL439743 | 333693 | 0 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 422 | 9 | 2 | 6 | 3.9 | CCCc1nc(CO)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(01)81143-4 | |||
| 44287536 | 317433 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 381 | 9 | 1 | 5 | 4.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(CCC)C(=O)O)cc1 | 10.1016/0960-894X(94)00476-V | |||
| CHEMBL41534 | 317433 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 381 | 9 | 1 | 5 | 4.4 | CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(CCC)C(=O)O)cc1 | 10.1016/0960-894X(94)00476-V | |||
| 76328690 | 214942 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 528 | 9 | 1 | 5 | 7.7 | CCCc1nn2ccc(-c3nc4ccccc4n3CCC)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115242 | 214942 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 528 | 9 | 1 | 5 | 7.7 | CCCc1nn2ccc(-c3nc4ccccc4n3CCC)cc2c1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| 44315059 | 469599 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| CHEMBL74144 | 469599 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 671 | 11 | 2 | 9 | 5.9 | CCc1nc2ccc(NC(=O)c3ccccn3)cc2c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCCC(C)C)cc1F | 10.1016/0960-894X(94)85036-4 | |||
| 44307257 | 202662 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 326 | 4 | 1 | 6 | 3.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81148-3 | |||
| CHEMBL304116 | 202662 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 326 | 4 | 1 | 6 | 3.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(O)c([N+](=O)[O-])c1 | 10.1016/S0960-894X(01)81148-3 | |||
| 135723836 | 201178 | 0 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 486 | 8 | 2 | 8 | 5.7 | CCCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| CHEMBL294598 | 201178 | 0 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 486 | 8 | 2 | 8 | 5.7 | CCCSc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2noc(O)n2)cc1 | 10.1016/0960-894X(95)00319-O | |||
| 15654733 | 469254 | 0 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 8 | 1 | 8 | 4.3 | C=CCOc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL71550 | 469254 | 0 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 8 | 1 | 8 | 4.3 | C=CCOc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 15288898 | 469201 | 0 | None | None | None | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 280 | 5 | 1 | 3 | 4.1 | CCCCc1nc2ccccc2n1Cc1ccc(O)cc1 | 10.1016/S0960-894X(01)81149-5 | |||
| CHEMBL71254 | 469201 | 0 | None | None | None | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 280 | 5 | 1 | 3 | 4.1 | CCCCc1nc2ccccc2n1Cc1ccc(O)cc1 | 10.1016/S0960-894X(01)81149-5 | |||
| 44303883 | 467968 | 0 | None | None | None | Rabbit | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 634 | 11 | 1 | 3 | 6.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(I)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| CHEMBL62744 | 467968 | 0 | None | None | None | Rabbit | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 634 | 11 | 1 | 3 | 6.4 | CCCCCN(CCCCC)C(=O)N1CCN(C(=O)N(c2ccccc2)c2ccc(I)cc2)[C@H](C(=O)O)C1 | 10.1016/S0960-894X(01)81007-6 | |||
| 14950500 | 199772 | 0 | None | None | None | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 401 | 7 | 1 | 6 | 4.3 | COCc1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1021/jm00061a016 | |||
| CHEMBL283770 | 199772 | 0 | None | None | None | Guinea pig | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 401 | 7 | 1 | 6 | 4.3 | COCc1c(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc(C)nc1C | 10.1021/jm00061a016 | |||
| 76308196 | 175948 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 410 | 8 | 3 | 6 | 3.9 | CCCCc1nnc(S)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237877 | 175948 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 410 | 8 | 3 | 6 | 3.9 | CCCCc1nnc(S)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10021888 | 102623 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 367 | 7 | 2 | 5 | 4.3 | CCCCc1nnc(S)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156408 | 102623 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 367 | 7 | 2 | 5 | 4.3 | CCCCc1nnc(S)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 10346301 | 333084 | 0 | None | None | None | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 475 | 6 | 1 | 5 | 6.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(F)(F)F)ccc2n1 | 10.1021/jm00100a007 | |||
| CHEMBL434615 | 333084 | 0 | None | None | None | Guinea pig | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 475 | 6 | 1 | 5 | 6.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(F)(F)F)ccc2n1 | 10.1021/jm00100a007 | |||
| 44373238 | 197407 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 1051 | 29 | 11 | 12 | 1.9 | CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1)C(=O)O | 10.1021/jm9504722 | |||
| CHEMBL267354 | 197407 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 1051 | 29 | 11 | 12 | 1.9 | CC[C@@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1)C(=O)O | 10.1021/jm9504722 | |||
| 44300735 | 200905 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 629 | 9 | 1 | 9 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CN3CCOCC3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| CHEMBL292829 | 200905 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 629 | 9 | 1 | 9 | 5.3 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2cc(CN3CCOCC3)sc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)81145-8 | |||
| 127035558 | 273794 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 577 | 11 | 2 | 5 | 7.8 | CCCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734763 | 273794 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 577 | 11 | 2 | 5 | 7.8 | CCCSc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 127026027 | 274678 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 628 | 12 | 3 | 8 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3752145 | 274678 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 628 | 12 | 3 | 8 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 19792197 | 388568 | 0 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 480 | 8 | 1 | 7 | 5.4 | CCCCc1nc2cc(C)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL54194 | 388568 | 0 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 480 | 8 | 1 | 7 | 5.4 | CCCCc1nc2cc(C)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792197 | 388568 | 0 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 480 | 8 | 1 | 7 | 5.4 | CCCCc1nc2cc(C)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL54194 | 388568 | 0 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 480 | 8 | 1 | 7 | 5.4 | CCCCc1nc2cc(C)cc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 1610 | 7967 | 67 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 3941 | 7967 | 67 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 3961 | 7967 | 67 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00019a004 | |||
| 19919870 | 176212 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 604 | 13 | 0 | 6 | 7.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(-c3ccccc3)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2259781 | 176212 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 604 | 13 | 0 | 6 | 7.3 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(-c3ccccc3)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 76315366 | 175903 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 549 | 11 | 2 | 8 | 4.4 | CCCCc1nnc(C(=O)N(C)Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237581 | 175903 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 549 | 11 | 2 | 8 | 4.4 | CCCCc1nnc(C(=O)N(C)Cc2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 9986953 | 99862 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 506 | 10 | 1 | 7 | 4.8 | CCCCc1nnc(C(=O)N(C)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL153825 | 99862 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 506 | 10 | 1 | 7 | 4.8 | CCCCc1nnc(C(=O)N(C)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 76315367 | 175905 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 5.5 | CCCCc1nnc(SC(C)(C)C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237583 | 175905 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 466 | 9 | 2 | 6 | 5.5 | CCCCc1nnc(SC(C)(C)C)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10002423 | 102469 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 423 | 8 | 1 | 5 | 5.9 | CCCCc1nnc(SC(C)(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156279 | 102469 | 0 | None | None | None | Rabbit | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 423 | 8 | 1 | 5 | 5.9 | CCCCc1nnc(SC(C)(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 172442030 | 387489 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 5.7 | CC[C@H](C)[C@H](N)C(=O)N1CCn2cc(-c3ccc4c(c3)CCCC4)nc2[C@@H]1CC1CCCCC1 | 10.1016/j.ejmech.2022.114520 | |||
| CHEMBL5397236 | 387489 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 462 | 6 | 1 | 4 | 5.7 | CC[C@H](C)[C@H](N)C(=O)N1CCn2cc(-c3ccc4c(c3)CCCC4)nc2[C@@H]1CC1CCCCC1 | 10.1016/j.ejmech.2022.114520 | |||
| 44274772 | 198893 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 493 | 8 | 2 | 7 | 4.6 | CCCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL277182 | 198893 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 493 | 8 | 2 | 7 | 4.6 | CCCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 10369902 | 329567 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 535 | 11 | 0 | 8 | 5.0 | CCCCc1ncc(/C=C2/C(=O)N(CCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL421629 | 329567 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 535 | 11 | 0 | 8 | 5.0 | CCCCc1ncc(/C=C2/C(=O)N(CCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44274772 | 198893 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 493 | 8 | 2 | 7 | 4.6 | CCCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL277182 | 198893 | 0 | None | None | None | Rabbit | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 493 | 8 | 2 | 7 | 4.6 | CCCCc1nc2ccc(NC(C)=O)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 44311616 | 202232 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL302485 | 202232 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2ccc(C(=O)c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 44311571 | 469358 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| CHEMBL72249 | 469358 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 610 | 12 | 1 | 8 | 6.9 | CCCc1nc(CC)c(C(=O)OCc2cccc(C(=O)c3ccccc3)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80077-3 | |||
| 15171413 | 216613 | 0 | None | None | None | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 429 | 6 | 1 | 5 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2F)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL314982 | 216613 | 0 | None | None | None | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 429 | 6 | 1 | 5 | 5.1 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2F)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 15818746 | 252114 | 0 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 529 | 8 | 1 | 5 | 5.3 | CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| CHEMBL36324 | 252114 | 0 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 529 | 8 | 1 | 5 | 5.3 | CCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/S0960-894X(01)80526-6 | |||
| 44311567 | 203063 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 607 | 11 | 2 | 8 | 6.4 | CCCc1nc(CN(Cc2ccccc2)C(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| CHEMBL306922 | 203063 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 607 | 11 | 2 | 8 | 6.4 | CCCc1nc(CN(Cc2ccccc2)C(=O)OC(C)(C)C)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(00)80076-1 | |||
| 14950509 | 164833 | 0 | None | None | None | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 443 | 8 | 1 | 7 | 4.6 | CCCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(C)n1 | 10.1021/jm00061a016 | |||
| CHEMBL21968 | 164833 | 0 | None | None | None | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 443 | 8 | 1 | 7 | 4.6 | CCCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c(C(=O)OC)c(C)n1 | 10.1021/jm00061a016 | |||
| 70684239 | 157875 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 528 | 9 | 1 | 6 | 6.8 | CCCCc1nc2ccc(C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058371 | 157875 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 528 | 9 | 1 | 6 | 6.8 | CCCCc1nc2ccc(C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 10763626 | 334122 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 402 | 8 | 2 | 6 | 3.8 | CCCCn1ncc(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| CHEMBL443559 | 334122 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 402 | 8 | 2 | 6 | 3.8 | CCCCn1ncc(C(=O)O)c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.ejmech.2011.05.056 | |||
| 10834137 | 24363 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 388 | 7 | 2 | 6 | 3.4 | CCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL115273 | 24363 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 388 | 7 | 2 | 6 | 3.4 | CCCc1ncc(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 44277487 | 199486 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccccn4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL281891 | 199486 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 604 | 8 | 0 | 9 | 5.5 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccc4)C(=O)c4ccccn4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 10457566 | 467882 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 473 | 8 | 1 | 8 | 1.9 | CCCc1cc(=O)n(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| CHEMBL62269 | 467882 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 473 | 8 | 1 | 8 | 1.9 | CCCc1cc(=O)n(CC(=O)N(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/0960-894X(95)00370-9 | |||
| 14956771 | 473325 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 482 | 8 | 1 | 9 | 3.8 | CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| CHEMBL87392 | 473325 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 482 | 8 | 1 | 9 | 3.8 | CCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9197-5 | |||
| 44277938 | 201283 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 599 | 10 | 1 | 9 | 4.8 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CCCC(=O)O)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29540 | 201283 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 599 | 10 | 1 | 9 | 4.8 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(CCCC(=O)O)C(=O)c4ccccc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 9912098 | 218147 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 460 | 9 | 3 | 7 | 4.0 | CCCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| CHEMBL320135 | 218147 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 460 | 9 | 3 | 7 | 4.0 | CCCCc1nc(C(C)(C)O)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm950450f | |||
| 19385680 | 199120 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 487 | 10 | 1 | 6 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1OC | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL279103 | 199120 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 487 | 10 | 1 | 6 | 5.8 | CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1OC | 10.1016/0960-894X(95)00185-V | |||
| 76330395 | 176357 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 567 | 12 | 0 | 9 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CSCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL2263543 | 176357 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 567 | 12 | 0 | 9 | 5.3 | CCCCc1ncc(/C=C2/C(=O)N(CSCC)C(=O)N2Cc2csc(C)n2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 44277593 | 199615 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 661 | 9 | 0 | 10 | 5.9 | COC(=O)c1ccc(CN(C(=O)c2ccccc2)c2ccc3ncn(Cc4ccc(-c5ccccc5-c5nnnn5C)cc4)c(=O)c3c2)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL282778 | 199615 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 661 | 9 | 0 | 10 | 5.9 | COC(=O)c1ccc(CN(C(=O)c2ccccc2)c2ccc3ncn(Cc4ccc(-c5ccccc5-c5nnnn5C)cc4)c(=O)c3c2)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 44277567 | 201525 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 605 | 8 | 0 | 10 | 4.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccncc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| CHEMBL29725 | 201525 | 0 | None | None | None | Rabbit | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 605 | 8 | 0 | 10 | 4.9 | Cn1nnnc1-c1ccccc1-c1ccc(Cn2cnc3ccc(N(Cc4ccccn4)C(=O)c4ccncc4)cc3c2=O)cc1 | 10.1016/0960-894X(95)00224-H | |||
| 10482886 | 39407 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 558 | 13 | 0 | 7 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(OC)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL121718 | 39407 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 558 | 13 | 0 | 7 | 5.7 | CCCCc1ncc(/C=C2/C(=O)N(CCCC)C(=O)N2Cc2ccc(OC)cc2)n1Cc1ccc(C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 70694738 | 157877 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 548 | 9 | 1 | 6 | 7.2 | CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058373 | 157877 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 548 | 9 | 1 | 6 | 7.2 | CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 17748251 | 184140 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL245444 | 184140 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 455 | 8 | 1 | 8 | 4.2 | CCCCc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-n2cccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 10006693 | 40922 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 514 | 11 | 1 | 6 | 5.4 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 10324179 | 40922 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 514 | 11 | 1 | 6 | 5.4 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL125454 | 40922 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 514 | 11 | 1 | 6 | 5.4 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| CHEMBL333126 | 40922 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 514 | 11 | 1 | 6 | 5.4 | CCCCc1ncc(/C=C2\C(=O)NC(=O)N2CCCC)n1Cc1ccc(-c2ccccc2C(=O)OC)cc1 | 10.1007/s00044-009-9205-9 | |||
| 70686382 | 157874 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 514 | 9 | 1 | 6 | 6.5 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058370 | 157874 | 0 | None | None | None | Bovine | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 514 | 9 | 1 | 6 | 6.5 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1016/j.bmc.2012.06.011 | |||
| 44294551 | 367715 | 0 | None | None | None | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| CHEMBL48459 | 367715 | 0 | None | None | None | Bovine | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(00)80474-6 | |||
| 76329883 | 175921 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 582 | 12 | 2 | 10 | 5.2 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237599 | 175921 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 582 | 12 | 2 | 10 | 5.2 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 127026338 | 274807 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 616 | 11 | 3 | 7 | 5.9 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3753277 | 274807 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 616 | 11 | 3 | 7 | 5.9 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 10482404 | 100726 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 539 | 11 | 1 | 9 | 5.6 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154531 | 100726 | 0 | None | None | None | Rabbit | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 539 | 11 | 1 | 9 | 5.6 | CCCCc1nnc(SCc2ccccc2C(=O)OC)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 24828427 | 197158 | 0 | None | None | None | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 439 | 7 | 1 | 7 | 4.2 | CCCCn1c2nc(C)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL265208 | 197158 | 0 | None | None | None | Rat | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 439 | 7 | 1 | 7 | 4.2 | CCCCn1c2nc(C)ccc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 127036103 | 273946 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 531 | 9 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)N[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736257 | 273946 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 531 | 9 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)N[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 4286584 | 469813 | 11 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 408 | 7 | 1 | 5 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL7641 | 469813 | 11 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 408 | 7 | 1 | 5 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44296954 | 202065 | 0 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 589 | 8 | 1 | 9 | 5.3 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CCC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL301325 | 202065 | 0 | None | None | None | Bovine | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 589 | 8 | 1 | 9 | 5.3 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CCC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 15662011 | 385876 | 0 | None | None | None | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52497 | 385876 | 0 | None | None | None | Bovine | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 10000596 | 44500 | 0 | None | None | None | Guinea pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 392 | 5 | 1 | 4 | 5.6 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2c1 | 10.1021/jm00100a007 | |||
| CHEMBL130858 | 44500 | 0 | None | None | None | Guinea pig | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 392 | 5 | 1 | 4 | 5.6 | Cc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2c1 | 10.1021/jm00100a007 | |||
| 4286584 | 469813 | 11 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 408 | 7 | 1 | 5 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL7641 | 469813 | 11 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 408 | 7 | 1 | 5 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 15662011 | 385876 | 0 | None | None | None | Bovine | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL52497 | 385876 | 0 | None | None | None | Bovine | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 5.0 | CCCCc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792137 | 176311 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 494 | 9 | 1 | 7 | 5.8 | CCCCc1nc2ccc(C)c(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL2261752 | 176311 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 494 | 9 | 1 | 7 | 5.8 | CCCCc1nc2ccc(C)c(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792185 | 372573 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cc(OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51349 | 372573 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cc(OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792137 | 176311 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 494 | 9 | 1 | 7 | 5.8 | CCCCc1nc2ccc(C)c(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL2261752 | 176311 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 494 | 9 | 1 | 7 | 5.8 | CCCCc1nc2ccc(C)c(C(=O)OCC)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-009-9182-z | |||
| 19792185 | 372573 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cc(OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| CHEMBL51349 | 372573 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 438 | 8 | 1 | 6 | 5.3 | CCCCc1nc2cc(OC)ccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1007/s00044-009-9182-z | |||
| 44275059 | 200251 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 590 | 7 | 2 | 7 | 6.6 | Cc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL287253 | 200251 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 590 | 7 | 2 | 7 | 6.6 | Cc1ccc2nc(-c3ccc(-c4ccccc4C(=O)O)cc3)n(Cc3ccc(-c4ccccc4-c4nn[nH]n4)cc3)c(=O)c2c1 | 10.1016/S0960-894X(00)80335-2 | |||
| 44459584 | 196969 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| CHEMBL26352 | 196969 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 426 | 7 | 1 | 4 | 5.5 | CCCCc1nc2ccc(C)cc2c(=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/S0960-894X(00)80334-0 | |||
| 127035545 | 273815 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 721 | 14 | 2 | 9 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3734955 | 273815 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 721 | 14 | 2 | 9 | 7.4 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 70686380 | 157870 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 458 | 6 | 1 | 6 | 5.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3cnc4ccccc43)cc2)c1C | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL2058366 | 157870 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 458 | 6 | 1 | 6 | 5.2 | Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3cnc4ccccc43)cc2)c1C | 10.1016/j.bmc.2012.06.011 | |||
| 44438900 | 294540 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 403 | 7 | 2 | 5 | 4.2 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| CHEMBL393305 | 294540 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 403 | 7 | 2 | 5 | 4.2 | CCCc1nc2cccc(C(=O)O)c2n1Cc1ccc(-n2cccc2C(=O)O)cc1 | 10.1016/j.bmcl.2007.02.042 | |||
| 15171407 | 470787 | 0 | None | None | None | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 445 | 6 | 1 | 5 | 5.6 | CCc1cc(OCc2ccc(-c3ccc(Cl)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| CHEMBL84792 | 470787 | 0 | None | None | None | Guinea pig | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 445 | 6 | 1 | 5 | 5.6 | CCc1cc(OCc2ccc(-c3ccc(Cl)cc3-c3nn[nH]n3)cc2)c2c(n1)CCCC2 | 10.1016/S0960-894X(01)80295-X | |||
| 127026337 | 274947 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 658 | 13 | 3 | 9 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| CHEMBL3754394 | 274947 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 658 | 13 | 3 | 9 | 5.8 | CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 | 10.1039/C5MD00169B | |||
| 15287882 | 102984 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.6 | CCCCc1nc2ccccc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL15670 | 102984 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 414 | 9 | 1 | 4 | 5.6 | CCCCc1nc2ccccc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)cc1 | 10.1016/0960-894X(95)00185-V | |||
| 127034875 | 273799 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)NC[C@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734819 | 273799 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)NC[C@H](O)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10389251 | 100920 | 0 | None | None | None | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 454 | 9 | 2 | 5 | 5.3 | CCCCc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL154708 | 100920 | 0 | None | None | None | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 454 | 9 | 2 | 5 | 5.3 | CCCCc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10389251 | 100920 | 0 | None | None | None | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 454 | 9 | 2 | 5 | 5.3 | CCCCc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL154708 | 100920 | 0 | None | None | None | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 454 | 9 | 2 | 5 | 5.3 | CCCCc1nnc(-c2ccccc2)n1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm00057a009 | |||
| 15654718 | 202355 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| CHEMBL303264 | 202355 | 0 | None | None | None | Bovine | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2ccc(C(=O)O)cc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00067a016 | |||
| 76319034 | 175915 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 572 | 12 | 2 | 8 | 6.4 | CCCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237593 | 175915 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 572 | 12 | 2 | 8 | 6.4 | CCCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 76322691 | 175918 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 554 | 12 | 2 | 9 | 5.4 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237596 | 175918 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 554 | 12 | 2 | 9 | 5.4 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 127034916 | 273844 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 668 | 12 | 2 | 8 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3735302 | 273844 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 668 | 12 | 2 | 8 | 6.6 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 10052714 | 102431 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 529 | 11 | 1 | 7 | 6.9 | CCCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL156243 | 102431 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 529 | 11 | 1 | 7 | 6.9 | CCCCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 10029367 | 103918 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 511 | 11 | 1 | 8 | 5.8 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL157565 | 103918 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 511 | 11 | 1 | 8 | 5.8 | CCCCc1nnc(SCc2cccc(OC)c2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 44296945 | 202098 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 653 | 10 | 1 | 10 | 5.7 | CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)OC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL301569 | 202098 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 653 | 10 | 1 | 10 | 5.7 | CCCCc1nc2ccc([C@@H]3[C@@H]4C(=O)OC[C@@H]4ON3Cc3ccccc3)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 71521417 | 177705 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 581 | 6 | 1 | 7 | 6.2 | CCc1nc2ccn(Cc3ccccc3C(F)(F)F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| CHEMBL2322446 | 177705 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 581 | 6 | 1 | 7 | 6.2 | CCc1nc2ccn(Cc3ccccc3C(F)(F)F)c(=O)c2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1016/j.bmcl.2012.11.088 | |||
| 44274747 | 199865 | 0 | None | None | None | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 621 | 8 | 2 | 9 | 6.2 | O=C(O)c1ccccc1-c1ccc(-c2nc3ccc([N+](=O)[O-])cc3c(=O)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| CHEMBL284469 | 199865 | 0 | None | None | None | Rabbit | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 621 | 8 | 2 | 9 | 6.2 | O=C(O)c1ccccc1-c1ccc(-c2nc3ccc([N+](=O)[O-])cc3c(=O)n2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1016/S0960-894X(00)80335-2 | |||
| 127034917 | 273970 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 654 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| CHEMBL3736507 | 273970 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 654 | 12 | 2 | 8 | 6.2 | CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 | 10.1039/C4MD00499J | |||
| 1610 | 7967 | 67 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.06.011 | |||
| 3941 | 7967 | 67 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.06.011 | |||
| 3961 | 7967 | 67 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL191 | 7967 | 67 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2012.06.011 | |||
| 24828568 | 315443 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 424 | 7 | 1 | 5 | 4.8 | CCCCC1c2ncccc2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL410325 | 315443 | 0 | None | None | None | Rat | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 424 | 7 | 1 | 5 | 4.8 | CCCCC1c2ncccc2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 44270367 | 328219 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 505 | 9 | 1 | 5 | 6.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cc2ccccc2)c1 | 10.1016/0960-894X(95)00185-V | |||
| CHEMBL418354 | 328219 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 505 | 9 | 1 | 5 | 6.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(OC(C(=O)O)c2ccccc2)c(Cc2ccccc2)c1 | 10.1016/0960-894X(95)00185-V | |||
| 4286584 | 469813 | 11 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 408 | 7 | 1 | 5 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL7641 | 469813 | 11 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 408 | 7 | 1 | 5 | 5.3 | CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 19008901 | 125381 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 435 | 4 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1C1CCc2cc(-c3ccccc3-c3nn[nH]n3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL178380 | 125381 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 435 | 4 | 1 | 6 | 5.0 | CCc1nc2c(C)cc(C)nc2n1C1CCc2cc(-c3ccccc3-c3nn[nH]n3)ccc21 | 10.1021/jm200409s | |||
| 70688503 | 157987 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 601 | 11 | 2 | 8 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| CHEMBL2058858 | 157987 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 601 | 11 | 2 | 8 | 6.1 | CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2012.05.056 | |||
| 10005096 | 42757 | 0 | None | None | None | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 437 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(OC)c2n1 | 10.1021/jm00100a007 | |||
| CHEMBL128397 | 42757 | 0 | None | None | None | Guinea pig | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 437 | 7 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cccc(OC)c2n1 | 10.1021/jm00100a007 | |||
| 76317815 | 214945 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 555 | 10 | 2 | 6 | 6.6 | CCCc1nn2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| CHEMBL3115245 | 214945 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 555 | 10 | 2 | 6 | 6.6 | CCCc1nn2ccc(C(=O)NC(CC)c3ccccc3)cc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmcl.2014.01.004 | |||
| 176251273 | 467101 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 3.3 | CCCCC(=O)N1CCC2(CC1)CCN(c1ccccc1-c1nnn[nH]1)CC2 | 10.1021/acs.jmedchem.4c01617 | |||
| CHEMBL6168714 | 467101 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 3.3 | CCCCC(=O)N1CCC2(CC1)CCN(c1ccccc1-c1nnn[nH]1)CC2 | 10.1021/acs.jmedchem.4c01617 | |||
| 176251273 | 467101 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 3.3 | CCCCC(=O)N1CCC2(CC1)CCN(c1ccccc1-c1nnn[nH]1)CC2 | 10.1021/acs.jmedchem.4c01617 | |||
| CHEMBL6168714 | 467101 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 3.3 | CCCCC(=O)N1CCC2(CC1)CCN(c1ccccc1-c1nnn[nH]1)CC2 | 10.1021/acs.jmedchem.4c01617 | |||
| 76311801 | 175914 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 544 | 10 | 2 | 8 | 5.7 | CCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| CHEMBL2237592 | 175914 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 544 | 10 | 2 | 8 | 5.7 | CCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(NC(=O)c2ccccc2-c2nnn[nH]2)cc1 | 10.1007/s00044-011-9756-4 | |||
| 10032367 | 116843 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 501 | 9 | 1 | 7 | 6.1 | CCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| CHEMBL160573 | 116843 | 0 | None | None | None | Rabbit | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 501 | 9 | 1 | 7 | 6.1 | CCCc1nnc(SCc2ccc(Cl)cc2)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00057a009 | |||
| 9894404 | 385005 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 575 | 8 | 1 | 9 | 4.9 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL53174 | 385005 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 575 | 8 | 1 | 9 | 4.9 | CCCCc1nc2ccc([C@H]3[C@@H]4C(=O)CC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 22850888 | 386505 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.7 | CCCCc1nc2ccc([C@H]3[C@@H]4CCC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| CHEMBL52791 | 386505 | 0 | None | None | None | Bovine | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 561 | 8 | 1 | 8 | 5.7 | CCCCc1nc2ccc([C@H]3[C@@H]4CCC[C@@H]4ON3C)cc2c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)80377-2 | |||
| 132387 | 7872 | 20 | None | 9 | 2 | Rabbit | 10.3 | pKd | = | 10.3 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(c1ncccc1C(=O)O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81142-2 | |||
| 3938 | 7872 | 20 | None | 9 | 2 | Rabbit | 10.3 | pKd | = | 10.3 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(c1ncccc1C(=O)O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL416477 | 7872 | 20 | None | 9 | 2 | Rabbit | 10.3 | pKd | = | 10.3 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(c1ncccc1C(=O)O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/S0960-894X(01)81142-2 | |||
| 132387 | 7872 | 20 | None | 9 | 2 | Rabbit | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(c1ncccc1C(=O)O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm00098a018 | |||
| 3938 | 7872 | 20 | None | 9 | 2 | Rabbit | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(c1ncccc1C(=O)O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm00098a018 | |||
| CHEMBL416477 | 7872 | 20 | None | 9 | 2 | Rabbit | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(c1ncccc1C(=O)O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm00098a018 | |||
| 192314 | 233509 | 17 | None | None | None | Rabbit | 9.9 | pKd | = | 9.9 | Binding | ChEMBL | 429 | 9 | 2 | 7 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL333534 | 233509 | 17 | None | None | None | Rabbit | 9.9 | pKd | = | 9.9 | Binding | ChEMBL | 429 | 9 | 2 | 7 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1021/jm00098a018 | |||
| 15657904 | 370717 | 3 | None | None | None | Rabbit | 9.9 | pKd | = | 9.9 | Binding | ChEMBL | 415 | 8 | 2 | 7 | 3.4 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49410 | 370717 | 3 | None | None | None | Rabbit | 9.9 | pKd | = | 9.9 | Binding | ChEMBL | 415 | 8 | 2 | 7 | 3.4 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1016/S0960-894X(01)81142-2 | |||
| 10432780 | 329446 | 0 | None | None | None | Rabbit | 9.6 | pKd | = | 9.6 | Binding | ChEMBL | 429 | 8 | 2 | 7 | 3.7 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL421473 | 329446 | 0 | None | None | None | Rabbit | 9.6 | pKd | = | 9.6 | Binding | ChEMBL | 429 | 8 | 2 | 7 | 3.7 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| 15657949 | 40797 | 0 | None | None | None | Rabbit | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 428 | 9 | 2 | 6 | 4.4 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL125218 | 40797 | 0 | None | None | None | Rabbit | 9.5 | pKd | = | 9.5 | Binding | ChEMBL | 428 | 9 | 2 | 6 | 4.4 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL5075338 | 478566 | 0 | None | None | None | Human | 9.3 | pKd | = | 9.3 | Binding | ChEMBL | 597 | 13 | 5 | 7 | 3.5 | CCOC(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@@H](CC1CCCCC1)NC(=O)[C@@H](C)NC(=O)/C=C/c1ccc(O)c(O)c1 | 10.1021/acs.jmedchem.1c00123 | |||
| CHEMBL266899 | 486216 | 0 | None | None | None | Human | 9.3 | pKd | = | 9.3 | Binding | ChEMBL | 988 | 27 | 12 | 12 | -1.3 | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9507744 | |||
| 127030943 | 276523 | 0 | None | None | None | Human | 9.0 | pKd | = | 9.0 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787700 | 276523 | 0 | None | None | None | Human | 9.0 | pKd | = | 9.0 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| 44348262 | 40232 | 0 | None | None | None | Rabbit | 9.0 | pKd | = | 9 | Binding | ChEMBL | 469 | 6 | 1 | 6 | 4.0 | CCOC(=O)/C=C1\C2C3CCC(C3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL122891 | 40232 | 0 | None | None | None | Rabbit | 9.0 | pKd | = | 9 | Binding | ChEMBL | 469 | 6 | 1 | 6 | 4.0 | CCOC(=O)/C=C1\C2C3CCC(C3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 9912059 | 368648 | 0 | None | None | None | Rabbit | 9.0 | pKd | = | 9 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL48602 | 368648 | 0 | None | None | None | Rabbit | 9.0 | pKd | = | 9 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 10745817 | 238133 | 0 | None | None | None | Rat | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | 580 | 12 | 3 | 7 | 5.4 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2Cl)cc1 | 10.1021/jm991050l | |||
| CHEMBL344464 | 238133 | 0 | None | None | None | Rat | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | 580 | 12 | 3 | 7 | 5.4 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2Cl)cc1 | 10.1021/jm991050l | |||
| CHEMBL428475 | 488516 | 0 | None | None | None | Bovine | 8.9 | pKd | = | 8.9 | Binding | ChEMBL | 988 | 27 | 12 | 12 | -1.3 | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||
| 10094936 | 40719 | 0 | None | None | None | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL124772 | 40719 | 0 | None | None | None | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00098a018 | |||
| 1610 | 7967 | 67 | None | -3 | 3 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81127-6 | |||
| 3941 | 7967 | 67 | None | -3 | 3 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81127-6 | |||
| 3961 | 7967 | 67 | None | -3 | 3 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL191 | 7967 | 67 | None | -3 | 3 | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL216830 | 485190 | 30 | None | None | None | Human | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 1032 | 28 | 14 | 13 | -1.5 | CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/acs.jmedchem.8b00435 | |||
| 127034873 | 270461 | 0 | None | None | None | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735744 | 270461 | 0 | None | None | None | Rabbit | 8.8 | pKd | = | 8.8 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 127035715 | 273881 | 0 | None | None | None | Rabbit | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735652 | 273881 | 0 | None | None | None | Rabbit | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10408684 | 333783 | 0 | None | None | None | Rabbit | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 400 | 7 | 2 | 6 | 3.7 | CCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL440521 | 333783 | 0 | None | None | None | Rabbit | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 400 | 7 | 2 | 6 | 3.7 | CCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncccc1C(=O)O | 10.1021/jm00098a018 | |||
| 44348285 | 40321 | 0 | None | None | None | Rabbit | 8.0 | pKd | = | 8 | Binding | ChEMBL | 481 | 6 | 1 | 6 | 4.2 | CCOC(=O)/C=C1\C2C3C=CC(CC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL123208 | 40321 | 0 | None | None | None | Rabbit | 8.0 | pKd | = | 8 | Binding | ChEMBL | 481 | 6 | 1 | 6 | 4.2 | CCOC(=O)/C=C1\C2C3C=CC(CC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294528 | 202138 | 0 | None | None | None | Rabbit | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 440 | 8 | 1 | 9 | 3.4 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nnn2C | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL301819 | 202138 | 0 | None | None | None | Rabbit | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 440 | 8 | 1 | 9 | 3.4 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nnn2C | 10.1016/S0960-894X(01)81142-2 | |||
| 44294996 | 372901 | 0 | None | None | None | Rabbit | 7.0 | pKd | = | 7 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL51622 | 372901 | 0 | None | None | None | Rabbit | 7.0 | pKd | = | 7 | Binding | ChEMBL | 501 | 10 | 1 | 6 | 5.7 | CCCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(01)81127-6 | |||
| 10629796 | 197209 | 0 | None | 6 | 2 | Bovine | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | |||
| 44339988 | 197209 | 0 | None | 6 | 2 | Bovine | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | |||
| CHEMBL265681 | 197209 | 0 | None | 6 | 2 | Bovine | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | |||
| CHEMBL411624 | 197209 | 0 | None | 6 | 2 | Bovine | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | |||
| 9957348 | 369989 | 0 | None | None | None | Rabbit | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 493 | 9 | 1 | 8 | 5.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)OC)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL48868 | 369989 | 0 | None | None | None | Rabbit | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 493 | 9 | 1 | 8 | 5.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)OC)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| 11744384 | 65973 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 448 | 11 | 3 | 6 | 5.2 | CCCCc1ncc(CNc2cc(N=[N+]=[N-])ccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL141065 | 65973 | 0 | None | None | None | Rat | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 448 | 11 | 3 | 6 | 5.2 | CCCCc1ncc(CNc2cc(N=[N+]=[N-])ccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| 44294791 | 367259 | 0 | None | None | None | Rabbit | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 437 | 8 | 1 | 8 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2nccnc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL48145 | 367259 | 0 | None | None | None | Rabbit | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 437 | 8 | 1 | 8 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2nccnc12 | 10.1016/S0960-894X(01)81142-2 | |||
| 9909542 | 351430 | 0 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 411 | 7 | 2 | 7 | 3.6 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2ncnc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL46392 | 351430 | 0 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 411 | 7 | 2 | 7 | 3.6 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2ncnc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| 10365342 | 232539 | 0 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 429 | 9 | 3 | 7 | 4.0 | CCCCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00098a018 | |||
| CHEMBL331983 | 232539 | 0 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 429 | 9 | 3 | 7 | 4.0 | CCCCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00098a018 | |||
| 44383615 | 330813 | 0 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\CC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL425139 | 330813 | 0 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\CC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294551 | 367715 | 0 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL48459 | 367715 | 0 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCC1(CC)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(01)81127-6 | |||
| 9807638 | 370397 | 0 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\CC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL49192 | 370397 | 0 | None | None | None | Rabbit | 7.9 | pKd | = | 7.9 | Binding | ChEMBL | 471 | 6 | 1 | 6 | 4.7 | CCOC(=O)/C=C1\CC2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294464 | 371018 | 0 | None | None | None | Rabbit | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 397 | 6 | 3 | 7 | 3.4 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c[nH]nc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49587 | 371018 | 0 | None | None | None | Rabbit | 6.9 | pKd | = | 6.9 | Binding | ChEMBL | 397 | 6 | 3 | 7 | 3.4 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c[nH]nc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| 71623945 | 273903 | 0 | None | None | None | Rabbit | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735839 | 273903 | 0 | None | None | None | Rabbit | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44295057 | 201464 | 0 | None | None | None | Rabbit | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 473 | 7 | 1 | 6 | 4.8 | CCOC(=O)/C=C1\CC(C)(C(C)C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL296731 | 201464 | 0 | None | None | None | Rabbit | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 473 | 7 | 1 | 6 | 4.8 | CCOC(=O)/C=C1\CC(C)(C(C)C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294699 | 370543 | 0 | None | None | None | Rabbit | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 501 | 9 | 1 | 8 | 5.1 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2Cc1ccccc1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49294 | 370543 | 0 | None | None | None | Rabbit | 6.8 | pKd | = | 6.8 | Binding | ChEMBL | 501 | 9 | 1 | 8 | 5.1 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2Cc1ccccc1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL408098 | 488001 | 0 | None | None | None | Bovine | 5.8 | pKd | = | 5.8 | Binding | ChEMBL | 1242 | 45 | 11 | 12 | 6.1 | CCCCCCCCCCCCCCCCCCOc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](CC2=CCCC=C2)C(=O)O)C(C)C)cc1 | 10.1021/jm9608669 | |||
| CHEMBL268804 | 486271 | 0 | None | -2 | 2 | Bovine | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1038 | 27 | 12 | 12 | -0.1 | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||
| CHEMBL406519 | 487914 | 0 | None | None | None | Bovine | 7.8 | pKd | = | 7.8 | Binding | ChEMBL | 1046 | 28 | 13 | 13 | -2.0 | CC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||
| 1610 | 7967 | 67 | None | -3 | 3 | Rabbit | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| 3941 | 7967 | 67 | None | -3 | 3 | Rabbit | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| 3961 | 7967 | 67 | None | -3 | 3 | Rabbit | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL191 | 7967 | 67 | None | -3 | 3 | Rabbit | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.ejmech.2015.09.010 | |||
| 44348369 | 40225 | 0 | None | None | None | Rabbit | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 495 | 6 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\C2C3C=CC(CCC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL122855 | 40225 | 0 | None | None | None | Rabbit | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 495 | 6 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\C2C3C=CC(CCC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 172198 | 866 | 40 | None | -2 | 3 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9507744 | |||
| 2504 | 866 | 40 | None | -2 | 3 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9507744 | |||
| 5272 | 866 | 40 | None | -2 | 3 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9507744 | |||
| CHEMBL408403 | 866 | 40 | None | -2 | 3 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9507744 | |||
| DB11842 | 866 | 40 | None | -2 | 3 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9507744 | |||
| P01015 | 866 | 40 | None | -2 | 3 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9507744 | |||
| P01019 | 866 | 40 | None | -2 | 3 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9507744 | |||
| P11859 | 866 | 40 | None | -2 | 3 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9507744 | |||
| 9912059 | 368648 | 0 | None | None | None | Rabbit | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL48602 | 368648 | 0 | None | None | None | Rabbit | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 459 | 7 | 1 | 6 | 4.5 | CCOC(=O)/C=C1\CC(C)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294466 | 371131 | 0 | None | None | None | Rabbit | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 451 | 7 | 3 | 7 | 4.4 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(=O)O)ccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49663 | 371131 | 0 | None | None | None | Rabbit | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 451 | 7 | 3 | 7 | 4.4 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(C(=O)O)ccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| 44294483 | 201858 | 0 | None | None | None | Rabbit | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 437 | 7 | 2 | 7 | 4.7 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL299741 | 201858 | 0 | None | None | None | Rabbit | 8.6 | pKd | = | 8.6 | Binding | ChEMBL | 437 | 7 | 2 | 7 | 4.7 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| 15294417 | 367439 | 0 | None | None | None | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 407 | 6 | 2 | 6 | 4.7 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL48270 | 367439 | 0 | None | None | None | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 407 | 6 | 2 | 6 | 4.7 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ccccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL415025 | 488380 | 0 | None | None | None | Human | 7.7 | pKd | = | 7.7 | Binding | ChEMBL | 1035 | 23 | 12 | 14 | -1.2 | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCSS[C@@H]2C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@@H](Cc2c[nH]cn2)NC1=O)C(C)C | 10.1021/jm9507744 | |||
| CHEMBL384349 | 487636 | 0 | None | -2 | 2 | Bovine | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 1276 | 42 | 11 | 13 | 5.5 | CCCCCCCCCCCCCCCC(=O)Oc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccc3ccccc3c2)C(=O)O)C(C)C)cc1 | 10.1021/jm9608669 | |||
| CHEMBL402669 | 487832 | 0 | None | None | None | Bovine | 5.7 | pKd | = | 5.7 | Binding | ChEMBL | 1334 | 43 | 12 | 14 | 5.2 | CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||
| CHEMBL406170 | 487899 | 0 | None | None | None | Human | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 1021 | 23 | 12 | 14 | -1.6 | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CSS[C@@H]2C[C@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@@H](Cc2c[nH]cn2)NC1=O)C(C)C | 10.1021/jm9507744 | |||
| 127035717 | 270460 | 0 | None | None | None | Rabbit | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735409 | 270460 | 0 | None | None | None | Rabbit | 7.6 | pKd | = | 7.6 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NC[C@@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10701559 | 311628 | 0 | None | None | None | Bovine | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 1227 | 42 | 11 | 13 | 4.9 | CCCCCCCCCCCCCCCC(=O)OCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||
| CHEMBL405031 | 311628 | 0 | None | None | None | Bovine | 5.6 | pKd | = | 5.6 | Binding | ChEMBL | 1227 | 42 | 11 | 13 | 4.9 | CCCCCCCCCCCCCCCC(=O)OCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||
| 44294540 | 201947 | 0 | None | None | None | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 455 | 8 | 2 | 9 | 3.7 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(O)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL300438 | 201947 | 0 | None | None | None | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 455 | 8 | 2 | 9 | 3.7 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(O)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| 9864307 | 40314 | 0 | None | None | None | Rabbit | 5.5 | pKd | = | 5.5 | Binding | ChEMBL | 373 | 6 | 3 | 7 | 2.6 | O=C(O)c1cncnc1NCc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00098a018 | |||
| CHEMBL123152 | 40314 | 0 | None | None | None | Rabbit | 5.5 | pKd | = | 5.5 | Binding | ChEMBL | 373 | 6 | 3 | 7 | 2.6 | O=C(O)c1cncnc1NCc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00098a018 | |||
| 70682146 | 157989 | 0 | None | None | None | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL2058860 | 157989 | 0 | None | None | None | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 569 | 10 | 2 | 6 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCC(C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 127036108 | 273823 | 0 | None | None | None | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735098 | 273823 | 0 | None | None | None | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 127035514 | 273865 | 0 | None | None | None | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735446 | 273865 | 0 | None | None | None | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44382928 | 121992 | 0 | None | None | None | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 4.3 | CCOC(=O)/C=C1\CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL170196 | 121992 | 0 | None | None | None | Rabbit | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 4.3 | CCOC(=O)/C=C1\CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 9978737 | 237678 | 1 | None | None | None | Rat | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 407 | 10 | 3 | 5 | 4.3 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL342261 | 237678 | 1 | None | None | None | Rat | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 407 | 10 | 3 | 5 | 4.3 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL415157 | 488385 | 0 | None | 10 | 2 | Bovine | 8.5 | pKd | = | 8.5 | Binding | ChEMBL | 1226 | 42 | 11 | 13 | 4.4 | CCCCCCCCCCCCCCCC(=O)Oc1ccc(C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N2CCC[C@H]2C(=O)N[C@H](Cc2ccccc2)C(=O)O)C(C)C)cc1 | 10.1021/jm9608669 | |||
| 127036107 | 273953 | 0 | None | None | None | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736319 | 273953 | 0 | None | None | None | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 561 | 11 | 2 | 5 | 6.8 | CCCc1nc2c(C)cc(C(=O)N[C@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 1610 | 7967 | 67 | None | -3 | 3 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81142-2 | |||
| 3941 | 7967 | 67 | None | -3 | 3 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81142-2 | |||
| 3961 | 7967 | 67 | None | -3 | 3 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL191 | 7967 | 67 | None | -3 | 3 | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/S0960-894X(01)81142-2 | |||
| 127036297 | 273869 | 0 | None | None | None | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735492 | 273869 | 0 | None | None | None | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44382968 | 330120 | 0 | None | None | None | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\CC2(CCCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL422912 | 330120 | 0 | None | None | None | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\CC2(CCCCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44295009 | 370420 | 0 | None | None | None | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL49207 | 370420 | 0 | None | None | None | Rabbit | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294967 | 371567 | 0 | None | None | None | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 467 | 9 | 1 | 8 | 4.6 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(CC)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL50109 | 371567 | 0 | None | None | None | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 467 | 9 | 1 | 8 | 4.6 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(CC)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| 155541125 | 347083 | 0 | None | None | None | Human | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | 10.1021/acs.jmedchem.8b00435 | |||
| CHEMBL4517561 | 347083 | 0 | None | None | None | Human | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 904 | 27 | 12 | 11 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(C)C)C(=O)O | 10.1021/acs.jmedchem.8b00435 | |||
| 44295090 | 201771 | 0 | None | None | None | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL299151 | 201771 | 0 | None | None | None | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 487 | 9 | 1 | 6 | 5.3 | CCCCC1(C)CC(=O)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)/C(=C/C(=O)OCC)C1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL264230 | 486122 | 0 | None | -3 | 2 | Bovine | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 1096 | 28 | 13 | 13 | -0.9 | CC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||
| 44294520 | 367603 | 0 | None | None | None | Rabbit | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 411 | 7 | 2 | 7 | 3.6 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2nncc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL48400 | 367603 | 0 | None | None | None | Rabbit | 6.5 | pKd | = | 6.5 | Binding | ChEMBL | 411 | 7 | 2 | 7 | 3.6 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2nncc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| 44294485 | 337084 | 0 | None | None | None | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 479 | 9 | 2 | 7 | 5.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2cc(C(=O)O)ccc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL448727 | 337084 | 0 | None | None | None | Rabbit | 7.5 | pKd | = | 7.5 | Binding | ChEMBL | 479 | 9 | 2 | 7 | 5.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2cc(C(=O)O)ccc12 | 10.1016/S0960-894X(01)81142-2 | |||
| 44295010 | 370492 | 0 | None | None | None | Rabbit | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 4.1 | CCOC(=O)/C=C1\CC(C)(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL49262 | 370492 | 0 | None | None | None | Rabbit | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 445 | 6 | 1 | 6 | 4.1 | CCOC(=O)/C=C1\CC(C)(C)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294515 | 374874 | 0 | None | None | None | Rabbit | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 501 | 9 | 1 | 9 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc([S+](C)[O-])n2C | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL51987 | 374874 | 0 | None | None | None | Rabbit | 7.4 | pKd | = | 7.4 | Binding | ChEMBL | 501 | 9 | 1 | 9 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc([S+](C)[O-])n2C | 10.1016/S0960-894X(01)81142-2 | |||
| 44294676 | 371000 | 0 | None | None | None | Rabbit | 7.3 | pKd | = | 7.3 | Binding | ChEMBL | 451 | 7 | 1 | 7 | 4.7 | CCc1nc(N(C)Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49573 | 371000 | 0 | None | None | None | Rabbit | 7.3 | pKd | = | 7.3 | Binding | ChEMBL | 451 | 7 | 1 | 7 | 4.7 | CCc1nc(N(C)Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2cc(OC)ccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| 44294616 | 371457 | 0 | None | None | None | Rabbit | 7.3 | pKd | = | 7.3 | Binding | ChEMBL | 465 | 9 | 1 | 7 | 5.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(OC)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49952 | 371457 | 0 | None | None | None | Rabbit | 7.3 | pKd | = | 7.3 | Binding | ChEMBL | 465 | 9 | 1 | 7 | 5.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(OC)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL406888 | 487927 | 0 | None | None | None | Bovine | 6.3 | pKd | = | 6.3 | Binding | ChEMBL | 1284 | 43 | 12 | 14 | 4.0 | CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)C(C)C | 10.1021/jm9608669 | |||
| 44294905 | 372303 | 0 | None | None | None | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\CC2(CCCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL51084 | 372303 | 0 | None | None | None | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 485 | 6 | 1 | 6 | 5.1 | CCOC(=O)/C=C1\CC2(CCCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294465 | 370936 | 0 | None | None | None | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 411 | 6 | 2 | 8 | 3.4 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ncn(C)c2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49528 | 370936 | 0 | None | None | None | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 411 | 6 | 2 | 8 | 3.4 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2ncn(C)c2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| 1610 | 7967 | 67 | None | -3 | 3 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| 3941 | 7967 | 67 | None | -3 | 3 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| 3961 | 7967 | 67 | None | -3 | 3 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| CHEMBL191 | 7967 | 67 | None | -3 | 3 | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00098a018 | |||
| 127035716 | 273876 | 0 | None | None | None | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735588 | 273876 | 0 | None | None | None | Rabbit | 8.3 | pKd | = | 8.3 | Binding | ChEMBL | 545 | 10 | 2 | 4 | 7.2 | CCCc1nc2c(C)cc(C(=O)NC[C@H](C)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 172198 | 866 | 40 | None | -8 | 3 | Bovine | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9608669 | |||
| 2504 | 866 | 40 | None | -8 | 3 | Bovine | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9608669 | |||
| 5272 | 866 | 40 | None | -8 | 3 | Bovine | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9608669 | |||
| CHEMBL408403 | 866 | 40 | None | -8 | 3 | Bovine | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9608669 | |||
| DB11842 | 866 | 40 | None | -8 | 3 | Bovine | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9608669 | |||
| P01015 | 866 | 40 | None | -8 | 3 | Bovine | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9608669 | |||
| P01019 | 866 | 40 | None | -8 | 3 | Bovine | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9608669 | |||
| P11859 | 866 | 40 | None | -8 | 3 | Bovine | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9608669 | |||
| CHEMBL414918 | 488372 | 0 | None | None | None | Human | 7.2 | pKd | = | 7.2 | Binding | ChEMBL | 986 | 25 | 11 | 12 | -1.4 | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9507744 | |||
| 44348285 | 40321 | 0 | None | None | None | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 481 | 6 | 1 | 6 | 4.2 | CCOC(=O)/C=C1\C2C3C=CC(CC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL123208 | 40321 | 0 | None | None | None | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 481 | 6 | 1 | 6 | 4.2 | CCOC(=O)/C=C1\C2C3C=CC(CC3)C2C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44211278 | 369896 | 0 | None | None | None | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 480 | 9 | 2 | 8 | 4.4 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)O)nc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL48799 | 369896 | 0 | None | None | None | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 480 | 9 | 2 | 8 | 4.4 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)O)nc12 | 10.1016/S0960-894X(01)81142-2 | |||
| 44211265 | 351420 | 0 | None | None | None | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 425 | 8 | 2 | 7 | 4.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2ncnc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL46391 | 351420 | 0 | None | None | None | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 425 | 8 | 2 | 7 | 4.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2ncnc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| 127035515 | 273894 | 0 | None | None | None | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3735769 | 273894 | 0 | None | None | None | Rabbit | 8.2 | pKd | = | 8.2 | Binding | ChEMBL | 585 | 11 | 2 | 7 | 6.3 | CCCc1nc2c(C)cc(C(=O)N[C@@H](COC)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10629796 | 197209 | 0 | None | 6 | 2 | Bovine | 5.2 | pKd | = | 5.2 | Binding | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | |||
| 44339988 | 197209 | 0 | None | 6 | 2 | Bovine | 5.2 | pKd | = | 5.2 | Binding | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | |||
| CHEMBL265681 | 197209 | 0 | None | 6 | 2 | Bovine | 5.2 | pKd | = | 5.2 | Binding | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | |||
| CHEMBL411624 | 197209 | 0 | None | 6 | 2 | Bovine | 5.2 | pKd | = | 5.2 | Binding | ChEMBL | 989 | 27 | 12 | 12 | -1.1 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | |||
| 44211267 | 351723 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 469 | 9 | 2 | 9 | 3.2 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2CC(=O)O | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL46433 | 351723 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 469 | 9 | 2 | 9 | 3.2 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2CC(=O)O | 10.1016/S0960-894X(01)81142-2 | |||
| 127036105 | 273955 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3736336 | 273955 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 547 | 10 | 3 | 5 | 6.2 | CCCc1nc2c(C)cc(C(=O)N[C@@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL412717 | 488245 | 0 | None | None | None | Bovine | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 1004 | 27 | 13 | 13 | -2.2 | CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9608669 | |||
| 127036106 | 273814 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL3734949 | 273814 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 571 | 10 | 3 | 7 | 5.7 | CCCc1nc2c(C)cc(C(=O)N[C@H](CO)c3ccccc3)cc2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 44211263 | 375170 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 439 | 8 | 2 | 7 | 4.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2nc(C)nc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL52036 | 375170 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 439 | 8 | 2 | 7 | 4.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1[nH]cnc2nc(C)nc1-2 | 10.1016/S0960-894X(01)81142-2 | |||
| 44295009 | 370420 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| CHEMBL49207 | 370420 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 473 | 8 | 1 | 6 | 4.9 | CCOC(=O)/C=C1\CC(CC)(CC)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/S0960-894X(01)81127-6 | |||
| 44294721 | 201351 | 0 | None | None | None | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 464 | 8 | 1 | 9 | 3.9 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(C#N)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL295935 | 201351 | 0 | None | None | None | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 464 | 8 | 1 | 9 | 3.9 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(C#N)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| 10321186 | 39406 | 0 | None | None | None | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.0 | CCCCc1ncc(C(=O)O)c(N(C)Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00098a018 | |||
| CHEMBL121705 | 39406 | 0 | None | None | None | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.0 | CCCCc1ncc(C(=O)O)c(N(C)Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00098a018 | |||
| 44294518 | 371493 | 0 | None | None | None | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 469 | 9 | 2 | 9 | 3.2 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ncn(CC(=O)O)c12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL50007 | 371493 | 0 | None | None | None | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 469 | 9 | 2 | 9 | 3.2 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ncn(CC(=O)O)c12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL216678 | 485185 | 0 | None | None | None | Human | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 1035 | 23 | 12 | 14 | -1.2 | CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CCSS[C@@H]2C[C@@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)O)N(C2)C(=O)[C@@H](Cc2c[nH]cn2)NC1=O)C(C)C | 10.1021/jm9507744 | |||
| 44294610 | 371365 | 0 | None | None | None | Rabbit | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 436 | 8 | 1 | 7 | 4.7 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2cccnc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49848 | 371365 | 0 | None | None | None | Rabbit | 6.1 | pKd | = | 6.1 | Binding | ChEMBL | 436 | 8 | 1 | 7 | 4.7 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2cccnc12 | 10.1016/S0960-894X(01)81142-2 | |||
| 73346386 | 183425 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| CHEMBL2435818 | 183425 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 531 | 10 | 2 | 4 | 6.7 | CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1016/j.ejmech.2015.09.010 | |||
| 10048997 | 39394 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 442 | 9 | 2 | 6 | 4.7 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ccc1C(=O)O | 10.1021/jm00098a018 | |||
| CHEMBL121635 | 39394 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 442 | 9 | 2 | 6 | 4.7 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ccc1C(=O)O | 10.1021/jm00098a018 | |||
| 44211264 | 201920 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 439 | 8 | 1 | 8 | 4.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2C | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL300194 | 201920 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 439 | 8 | 1 | 8 | 4.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1ncn2C | 10.1016/S0960-894X(01)81142-2 | |||
| 44294618 | 371604 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 437 | 7 | 2 | 7 | 4.7 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(OC)cccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL50174 | 371604 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | ChEMBL | 437 | 7 | 2 | 7 | 4.7 | CCc1nc(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)c2c(OC)cccc2n1 | 10.1016/S0960-894X(01)81142-2 | |||
| 44294637 | 328150 | 0 | None | None | None | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 451 | 8 | 2 | 7 | 5.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(O)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL417910 | 328150 | 0 | None | None | None | Rabbit | 7.1 | pKd | = | 7.1 | Binding | ChEMBL | 451 | 8 | 2 | 7 | 5.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(O)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| 44294822 | 201293 | 0 | None | None | None | Rabbit | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 453 | 8 | 1 | 8 | 4.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(C)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL295498 | 201293 | 0 | None | None | None | Rabbit | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 453 | 8 | 1 | 8 | 4.3 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2c1nc(C)n2C | 10.1016/S0960-894X(01)81142-2 | |||
| 44211277 | 371188 | 0 | None | None | None | Rabbit | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 479 | 9 | 2 | 7 | 5.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)O)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL49715 | 371188 | 0 | None | None | None | Rabbit | 8.0 | pKd | = | 8.0 | Binding | ChEMBL | 479 | 9 | 2 | 7 | 5.0 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ccc(C(=O)O)cc12 | 10.1016/S0960-894X(01)81142-2 | |||
| 44294459 | 367429 | 0 | None | None | None | Rabbit | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 425 | 7 | 1 | 8 | 3.6 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ncn(C)c12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL48259 | 367429 | 0 | None | None | None | Rabbit | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 425 | 7 | 1 | 8 | 3.6 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2ncn(C)c12 | 10.1016/S0960-894X(01)81142-2 | |||
| 44294539 | 329792 | 0 | None | None | None | Rabbit | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 426 | 7 | 1 | 8 | 4.2 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2oc(C)nc12 | 10.1016/S0960-894X(01)81142-2 | |||
| CHEMBL422050 | 329792 | 0 | None | None | None | Rabbit | 7.0 | pKd | = | 7.0 | Binding | ChEMBL | 426 | 7 | 1 | 8 | 4.2 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncnc2oc(C)nc12 | 10.1016/S0960-894X(01)81142-2 | |||
| 172198 | 866 | 40 | None | -1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| 2504 | 866 | 40 | None | -1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| 5272 | 866 | 40 | None | -1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL408403 | 866 | 40 | None | -1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| DB11842 | 866 | 40 | None | -1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| P01015 | 866 | 40 | None | -1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| P01019 | 866 | 40 | None | -1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| P11859 | 866 | 40 | None | -1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| 3542 | 484387 | 24 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.ejmech.2013.01.044 | |||
| CHEMBL938 | 484387 | 24 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1016/j.ejmech.2013.01.044 | |||
| 3542 | 484387 | 24 | None | 1 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/ml500278g | |||
| CHEMBL938 | 484387 | 24 | None | 1 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/ml500278g | |||
| 1056 | 6857 | 72 | None | None | None | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1007/s00044-008-9152-x | |||
| 2405 | 6857 | 72 | None | None | None | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1007/s00044-008-9152-x | |||
| 77999 | 6857 | 72 | None | None | None | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1007/s00044-008-9152-x | |||
| CHEMBL121 | 6857 | 72 | None | None | None | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1007/s00044-008-9152-x | |||
| DB00412 | 6857 | 72 | None | None | None | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | 10.1007/s00044-008-9152-x | |||
| 2583 | 8231 | 75 | None | None | None | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1007/s00044-008-9153-9 | |||
| 592 | 8231 | 75 | None | None | None | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1007/s00044-008-9153-9 | |||
| 65999 | 8231 | 75 | None | None | None | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1007/s00044-008-9153-9 | |||
| CHEMBL1017 | 8231 | 75 | None | None | None | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1007/s00044-008-9153-9 | |||
| DB00966 | 8231 | 75 | None | None | None | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1007/s00044-008-9153-9 | |||
| 2583 | 8231 | 75 | None | None | None | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm901272d | |||
| 592 | 8231 | 75 | None | None | None | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm901272d | |||
| 65999 | 8231 | 75 | None | None | None | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm901272d | |||
| CHEMBL1017 | 8231 | 75 | None | None | None | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm901272d | |||
| DB00966 | 8231 | 75 | None | None | None | Rat | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | 10.1021/jm901272d | |||
| 3542 | 484387 | 24 | None | 1 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/acschembio.7b00481 | |||
| CHEMBL938 | 484387 | 24 | None | 1 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/acschembio.7b00481 | |||
| 172198 | 866 | 40 | None | -1 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| 2504 | 866 | 40 | None | -1 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| 5272 | 866 | 40 | None | -1 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL408403 | 866 | 40 | None | -1 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| DB11842 | 866 | 40 | None | -1 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| P01015 | 866 | 40 | None | -1 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| P01019 | 866 | 40 | None | -1 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| P11859 | 866 | 40 | None | -1 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.5b01495 | |||
| 10390188 | 474162 | 0 | None | None | None | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 475 | 5 | 1 | 7 | 4.9 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| CHEMBL92950 | 474162 | 0 | None | None | None | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 475 | 5 | 1 | 7 | 4.9 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| CHEMBL1076604 | 484413 | 0 | None | None | None | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 1158 | 30 | 13 | 14 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||
| 3542 | 484387 | 24 | None | 1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/jm8007618 | |||
| CHEMBL938 | 484387 | 24 | None | 1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | 10.1021/jm8007618 | |||
| CHEMBL1076602 | 484411 | 0 | None | None | None | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 1101 | 27 | 10 | 13 | 2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||
| CHEMBL1076603 | 484412 | 0 | None | None | None | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 1154 | 31 | 13 | 13 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||
| 6918 | 2123 | 39 | None | 3 | 3 | Pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| 9804984 | 2123 | 39 | None | 3 | 3 | Pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL189568 | 2123 | 39 | None | 3 | 3 | Pig | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| 10479983 | 474231 | 0 | None | None | None | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 473 | 4 | 1 | 7 | 4.8 | Cc1cc(C)c2nc(C3CC3)n(Cc3ccc4c(-c5nnn[nH]5)cc5ccccc5c(=O)c4c3)c2n1 | 10.1021/jm00014a024 | |||
| CHEMBL93522 | 474231 | 0 | None | None | None | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 473 | 4 | 1 | 7 | 4.8 | Cc1cc(C)c2nc(C3CC3)n(Cc3ccc4c(-c5nnn[nH]5)cc5ccccc5c(=O)c4c3)c2n1 | 10.1021/jm00014a024 | |||
| 183134 | 7963 | 16 | None | None | None | Rat | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm00070a012 | |||
| 3939 | 7963 | 16 | None | None | None | Rat | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm00070a012 | |||
| CHEMBL7550 | 7963 | 16 | None | None | None | Rat | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 10.1021/jm00070a012 | |||
| 9826888 | 474742 | 0 | None | None | None | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 490 | 6 | 1 | 8 | 4.6 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2nc(OC)ccc2n1 | 10.1021/jm00014a024 | |||
| CHEMBL96552 | 474742 | 0 | None | None | None | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 490 | 6 | 1 | 8 | 4.6 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2nc(OC)ccc2n1 | 10.1021/jm00014a024 | |||
| 10004498 | 474183 | 0 | None | None | None | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 461 | 5 | 1 | 6 | 5.1 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)Cc1ccccc1C=C2c1nnn[nH]1 | 10.1021/jm00014a024 | |||
| CHEMBL93159 | 474183 | 0 | None | None | None | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 461 | 5 | 1 | 6 | 5.1 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)Cc1ccccc1C=C2c1nnn[nH]1 | 10.1021/jm00014a024 | |||
| 172198 | 866 | 40 | None | -1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9015747 | |||
| 2504 | 866 | 40 | None | -1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9015747 | |||
| 5272 | 866 | 40 | None | -1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9015747 | |||
| CHEMBL408403 | 866 | 40 | None | -1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9015747 | |||
| DB11842 | 866 | 40 | None | -1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9015747 | |||
| P01015 | 866 | 40 | None | -1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9015747 | |||
| P01019 | 866 | 40 | None | -1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9015747 | |||
| P11859 | 866 | 40 | None | -1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9015747 | |||
| CHEMBL1076663 | 484422 | 0 | None | None | None | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 1144 | 29 | 13 | 14 | 0.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9015747 | |||
| 4673492 | 8951 | 9 | None | 537 | 4 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1016/j.bmc.2013.09.004 | |||
| 8324 | 8951 | 9 | None | 537 | 4 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL159096 | 8951 | 9 | None | 537 | 4 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 438 | 6 | 1 | 5 | 4.5 | CCc1nc(CC)c2c(c1)N(Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(=O)CC2 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL1076601 | 484410 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1097 | 28 | 10 | 12 | 2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||
| CHEMBL1076632 | 484419 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1106 | 30 | 13 | 13 | 0.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)O | 10.1021/jm9015747 | |||
| 132387 | 7872 | 20 | None | None | None | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(c1ncccc1C(=O)O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm00070a012 | |||
| 3938 | 7872 | 20 | None | None | None | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(c1ncccc1C(=O)O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm00070a012 | |||
| CHEMBL416477 | 7872 | 20 | None | None | None | Rat | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 414 | 8 | 2 | 6 | 4.0 | CCCN(c1ncccc1C(=O)O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm00070a012 | |||
| 2541 | 7891 | 68 | None | 9 | 5 | Rabbit | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| 6907 | 7891 | 68 | None | 9 | 5 | Rabbit | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| CHEMBL1016 | 7891 | 68 | None | 9 | 5 | Rabbit | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/jm9504722 | |||
| 10344188 | 222126 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 459 | 5 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2ccccc2n1 | 10.1021/jm00014a024 | |||
| CHEMBL330298 | 222126 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 459 | 5 | 1 | 6 | 5.2 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2ccccc2n1 | 10.1021/jm00014a024 | |||
| CHEMBL404594 | 487833 | 18 | None | -4 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 968 | 28 | 12 | 12 | -1.1 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)[C@@H](C)CC)C(=O)O | 10.1021/ml500278g | |||
| 10004489 | 473701 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 461 | 4 | 1 | 7 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| CHEMBL90027 | 473701 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 461 | 4 | 1 | 7 | 4.5 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| 45102750 | 136113 | 3 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| CHEMBL1801740 | 136113 | 3 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 477 | 6 | 1 | 6 | 5.9 | CCc1nc2c(C)cc(CC(C)C)nc2n1[C@H]1CCc2cc(-c3ccccc3-c3nnn[nH]3)ccc21 | 10.1021/jm200409s | |||
| 11754146 | 315521 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 463 | 5 | 1 | 7 | 5.3 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1 | 10.1021/jm00014a024 | |||
| CHEMBL410417 | 315521 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 463 | 5 | 1 | 7 | 5.3 | CCCc1nc2c(C)cc(C)nc2n1Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1 | 10.1021/jm00014a024 | |||
| CHEMBL1076613 | 484415 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1186 | 30 | 13 | 14 | 1.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||
| CHEMBL1076633 | 484420 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1110 | 29 | 13 | 14 | 0.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(=O)O | 10.1021/jm9015747 | |||
| CHEMBL1076662 | 484421 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1140 | 30 | 13 | 13 | 0.7 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C | 10.1021/jm9015747 | |||
| CHEMBL1076603 | 484412 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1154 | 31 | 13 | 13 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||
| 11994289 | 163903 | 0 | None | -1 | 2 | Pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL217673 | 163903 | 0 | None | -1 | 2 | Pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 469 | 10 | 1 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 10031067 | 200517 | 5 | None | 2 | 3 | Pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL289614 | 200517 | 5 | None | 2 | 3 | Pig | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 127030943 | 276523 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787700 | 276523 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 1216 | 35 | 15 | 14 | -0.7 | CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| 87219032 | 349950 | 0 | None | None | None | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 541 | 13 | 3 | 6 | 5.6 | CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4588688 | 349950 | 0 | None | None | None | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 541 | 13 | 3 | 6 | 5.6 | CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F | 10.1021/acsmedchemlett.8b00462 | |||
| 10257882 | 7409 | 51 | None | 7 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm300682j | |||
| 8448 | 7409 | 51 | None | 7 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm300682j | |||
| CHEMBL539423 | 7409 | 51 | None | 7 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm300682j | |||
| DB12548 | 7409 | 51 | None | 7 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm300682j | |||
| 1481 | 7955 | 73 | None | 8317 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm300682j | |||
| 3749 | 7955 | 73 | None | 8317 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm300682j | |||
| 6908 | 7955 | 73 | None | 8317 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm300682j | |||
| CHEMBL1513 | 7955 | 73 | None | 8317 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm300682j | |||
| CHEMBL1076612 | 484414 | 0 | None | None | None | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1182 | 31 | 13 | 13 | 1.9 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccc(C(=O)c2ccccc2)cc1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||
| CHEMBL1076632 | 484419 | 0 | None | None | None | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1106 | 30 | 13 | 13 | 0.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)O | 10.1021/jm9015747 | |||
| 10257882 | 7409 | 51 | None | 7 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm058225d | |||
| 8448 | 7409 | 51 | None | 7 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm058225d | |||
| CHEMBL539423 | 7409 | 51 | None | 7 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm058225d | |||
| DB12548 | 7409 | 51 | None | 7 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 10.1021/jm058225d | |||
| 1481 | 7955 | 73 | None | 8317 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm058225d | |||
| 3749 | 7955 | 73 | None | 8317 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm058225d | |||
| 6908 | 7955 | 73 | None | 8317 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm058225d | |||
| CHEMBL1513 | 7955 | 73 | None | 8317 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm058225d | |||
| 14956739 | 473279 | 0 | None | None | None | Rabbit | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| CHEMBL87074 | 473279 | 0 | None | None | None | Rabbit | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 496 | 9 | 1 | 9 | 4.2 | CCCCc1nn(-c2ccccc2[N+](=O)[O-])c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| 3047757 | 332238 | 26 | None | None | None | Rabbit | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 554 | 10 | 1 | 9 | 5.2 | CCCCc1nc(C)n(Cc2sccc2C(=O)OC)c(=O)c1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/jm9504722 | |||
| CHEMBL429847 | 332238 | 26 | None | None | None | Rabbit | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 554 | 10 | 1 | 9 | 5.2 | CCCCc1nc(C)n(Cc2sccc2C(=O)OC)c(=O)c1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/jm9504722 | |||
| 172198 | 866 | 40 | None | -1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9015747 | |||
| 2504 | 866 | 40 | None | -1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9015747 | |||
| 5272 | 866 | 40 | None | -1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9015747 | |||
| CHEMBL408403 | 866 | 40 | None | -1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9015747 | |||
| DB11842 | 866 | 40 | None | -1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9015747 | |||
| P01015 | 866 | 40 | None | -1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9015747 | |||
| P01019 | 866 | 40 | None | -1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9015747 | |||
| P11859 | 866 | 40 | None | -1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/jm9015747 | |||
| CHEMBL1076633 | 484420 | 0 | None | None | None | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 1110 | 29 | 13 | 14 | 0.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(=O)O | 10.1021/jm9015747 | |||
| 10322229 | 240112 | 0 | None | None | None | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 464 | 8 | 2 | 6 | 4.9 | CCCCC1=NC(Cl)=C(C(=O)O)C(C)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL358335 | 240112 | 0 | None | None | None | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 464 | 8 | 2 | 6 | 4.9 | CCCCC1=NC(Cl)=C(C(=O)O)C(C)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 25141239 | 367196 | 0 | None | None | None | Pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 528 | 11 | 2 | 6 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NCc2ccccc2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL480906 | 367196 | 0 | None | None | None | Pig | 9.0 | pKi | = | 9 | Binding | ChEMBL | 528 | 11 | 2 | 6 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NCc2ccccc2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 10366402 | 473780 | 0 | None | None | None | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 448 | 5 | 2 | 8 | 3.8 | CCc1cc(NCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)n2nccc2n1 | 10.1021/jm00014a024 | |||
| CHEMBL90513 | 473780 | 0 | None | None | None | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 448 | 5 | 2 | 8 | 3.8 | CCc1cc(NCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)n2nccc2n1 | 10.1021/jm00014a024 | |||
| 1481 | 7955 | 73 | None | 8317 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| 3749 | 7955 | 73 | None | 8317 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| 6908 | 7955 | 73 | None | 8317 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| CHEMBL1513 | 7955 | 73 | None | 8317 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm020138n | |||
| 3936 | 4506 | 37 | None | -1 | 4 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| 6603900 | 4506 | 37 | None | -1 | 4 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL288174 | 4506 | 37 | None | -1 | 4 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| 3936 | 4506 | 37 | None | -1 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| 6603900 | 4506 | 37 | None | -1 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL288174 | 4506 | 37 | None | -1 | 4 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| 171356731 | 386299 | 0 | None | 1 | 2 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1060 | 30 | 14 | 13 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2022.128983 | |||
| CHEMBL5274111 | 386299 | 0 | None | 1 | 2 | Rat | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 1060 | 30 | 14 | 13 | -0.7 | CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1016/j.bmcl.2022.128983 | |||
| 14956757 | 139872 | 0 | None | None | None | Rabbit | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| CHEMBL19018 | 139872 | 0 | None | None | None | Rabbit | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 519 | 8 | 1 | 7 | 5.3 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| 45102601 | 334141 | 14 | None | 1995 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 527 | 12 | 3 | 6 | 5.4 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4435800 | 334141 | 14 | None | 1995 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 527 | 12 | 3 | 6 | 5.4 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1F | 10.1021/acsmedchemlett.8b00462 | |||
| 87218373 | 334802 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 541 | 13 | 3 | 6 | 5.6 | CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)c(F)c1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4445778 | 334802 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 541 | 13 | 3 | 6 | 5.6 | CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)c(F)c1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218514 | 350059 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 523 | 13 | 3 | 6 | 5.5 | CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4591218 | 350059 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 523 | 13 | 3 | 6 | 5.5 | CCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 10050044 | 221027 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 463 | 5 | 1 | 6 | 4.9 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2c(n1)CCCC2 | 10.1021/jm00014a024 | |||
| CHEMBL327903 | 221027 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 463 | 5 | 1 | 6 | 4.9 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2c(n1)CCCC2 | 10.1021/jm00014a024 | |||
| CHEMBL1076604 | 484413 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 1158 | 30 | 13 | 14 | 1.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||
| 145957897 | 317570 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 984 | 28 | 14 | 13 | -1.8 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)O | 10.1016/j.ejmech.2017.12.021 | |||
| CHEMBL4160691 | 317570 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 984 | 28 | 14 | 13 | -1.8 | CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)CC)C(=O)O | 10.1016/j.ejmech.2017.12.021 | |||
| 44320012 | 332677 | 0 | None | None | None | Rabbit | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 493 | 9 | 1 | 7 | 5.4 | CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| CHEMBL431411 | 332677 | 0 | None | None | None | Rabbit | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 493 | 9 | 1 | 7 | 5.4 | CCCCc1nn(-c2ccccc2C(C)C)c(=O)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm990504b | |||
| 10603443 | 78303 | 0 | None | None | None | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 587 | 13 | 3 | 8 | 5.6 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2N=[N+]=[N-])cc1 | 10.1021/jm991050l | |||
| CHEMBL143118 | 78303 | 0 | None | None | None | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 587 | 13 | 3 | 8 | 5.6 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2N=[N+]=[N-])cc1 | 10.1021/jm991050l | |||
| 9939191 | 199181 | 1 | None | None | None | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL279629 | 199181 | 1 | None | None | None | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 634 | 10 | 1 | 7 | 6.2 | CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 192314 | 233509 | 17 | None | None | None | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 429 | 9 | 2 | 7 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1021/jm00070a012 | |||
| CHEMBL333534 | 233509 | 17 | None | None | None | Rat | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 429 | 9 | 2 | 7 | 3.8 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1ncncc1C(=O)O | 10.1021/jm00070a012 | |||
| 72168 | 202747 | 18 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 554 | 8 | 2 | 7 | 6.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc2oc(-c3ccccc3-c3nnn[nH]3)c(Br)c2c1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL304639 | 202747 | 18 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 554 | 8 | 2 | 7 | 6.0 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc2oc(-c3ccccc3-c3nnn[nH]3)c(Br)c2c1 | 10.1016/j.bmc.2010.10.043 | |||
| 10393016 | 473869 | 0 | None | None | None | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 559 | 9 | 1 | 5 | 4.9 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL91113 | 473869 | 0 | None | None | None | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 559 | 9 | 1 | 5 | 4.9 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| 9895957 | 24953 | 18 | None | -5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1016/j.bmc.2012.06.011 | |||
| CHEMBL11706 | 24953 | 18 | None | -5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1016/j.bmc.2012.06.011 | |||
| 178301534 | 467807 | 0 | None | 398 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 1006 | 25 | 3 | 10 | 10.2 | CCCCc1nc(Cl)c(C(=O)NCCOCCOCCNC(=O)CCCCCN2/C(=C/C=C/C3=[N+](C)c4ccccc4C3(C)C)C(C)(C)c3ccccc32)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/acs.jmedchem.4c01693 | |||
| CHEMBL6198473 | 467807 | 0 | None | 398 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 1006 | 25 | 3 | 10 | 10.2 | CCCCc1nc(Cl)c(C(=O)NCCOCCOCCNC(=O)CCCCCN2/C(=C/C=C/C3=[N+](C)c4ccccc4C3(C)C)C(C)(C)c3ccccc32)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/acs.jmedchem.4c01693 | |||
| 9895957 | 24953 | 18 | None | -5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1021/jm020138n | |||
| CHEMBL11706 | 24953 | 18 | None | -5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1021/jm020138n | |||
| 155514738 | 334474 | 0 | None | None | None | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 656 | 15 | 4 | 8 | 5.3 | CCCCc1nc(Cl)c(CNC(=O)CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4440944 | 334474 | 0 | None | None | None | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 656 | 15 | 4 | 8 | 5.3 | CCCCc1nc(Cl)c(CNC(=O)CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 71465043 | 336503 | 0 | None | None | None | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 565 | 13 | 3 | 7 | 6.0 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC(C)C)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4470834 | 336503 | 0 | None | None | None | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 565 | 13 | 3 | 7 | 6.0 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC(C)C)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 53319274 | 120395 | 0 | None | None | None | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 559 | 9 | 1 | 7 | 4.2 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1668000 | 120395 | 0 | None | None | None | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 559 | 9 | 1 | 7 | 4.2 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3S(=O)(=O)NC(=O)c3ccccc3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | |||
| 9895957 | 24953 | 18 | None | -5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1021/jm058225d | |||
| CHEMBL11706 | 24953 | 18 | None | -5 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 659 | 11 | 1 | 7 | 6.8 | CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 | 10.1021/jm058225d | |||
| 2541 | 7891 | 68 | None | -9 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2017.12.021 | |||
| 6907 | 7891 | 68 | None | -9 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2017.12.021 | |||
| CHEMBL1016 | 7891 | 68 | None | -9 | 5 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1016/j.ejmech.2017.12.021 | |||
| 1610 | 7967 | 67 | None | -1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| 3941 | 7967 | 67 | None | -1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| 3961 | 7967 | 67 | None | -1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL191 | 7967 | 67 | None | -1 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmcl.2023.129349 | |||
| 44567746 | 374479 | 0 | None | None | None | Pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 478 | 10 | 2 | 6 | 4.7 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC2CC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL519274 | 374479 | 0 | None | None | None | Pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 478 | 10 | 2 | 6 | 4.7 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC2CC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 178301534 | 467807 | 0 | None | 398 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 1006 | 25 | 3 | 10 | 10.2 | CCCCc1nc(Cl)c(C(=O)NCCOCCOCCNC(=O)CCCCCN2/C(=C/C=C/C3=[N+](C)c4ccccc4C3(C)C)C(C)(C)c3ccccc32)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/acs.jmedchem.4c01693 | |||
| CHEMBL6198473 | 467807 | 0 | None | 398 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 1006 | 25 | 3 | 10 | 10.2 | CCCCc1nc(Cl)c(C(=O)NCCOCCOCCNC(=O)CCCCCN2/C(=C/C=C/C3=[N+](C)c4ccccc4C3(C)C)C(C)(C)c3ccccc32)n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/acs.jmedchem.4c01693 | |||
| 168475982 | 386192 | 3 | None | None | None | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 315 | 3 | 1 | 4 | 2.8 | CS(=O)(=O)n1c(-c2ccccc2)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5271484 | 386192 | 3 | None | None | None | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 315 | 3 | 1 | 4 | 2.8 | CS(=O)(=O)n1c(-c2ccccc2)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| 44567782 | 367057 | 0 | None | None | None | Pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 521 | 10 | 2 | 8 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)Nc2nccs2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL480341 | 367057 | 0 | None | None | None | Pig | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 521 | 10 | 2 | 8 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)Nc2nccs2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 44475015 | 335986 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 75031588 | 335986 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218444 | 335986 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4463203 | 335986 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4464191 | 335986 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4535903 | 335986 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 6918 | 2123 | 39 | None | -25118 | 3 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/acs.jmedchem.8b00294 | |||
| 9804984 | 2123 | 39 | None | -25118 | 3 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/acs.jmedchem.8b00294 | |||
| CHEMBL189568 | 2123 | 39 | None | -25118 | 3 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 475 | 10 | 1 | 7 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1cncc1)CC(C)C | 10.1021/acs.jmedchem.8b00294 | |||
| 44567709 | 373743 | 0 | None | None | None | Pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 438 | 9 | 2 | 6 | 3.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(N)=O)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL518157 | 373743 | 0 | None | None | None | Pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 438 | 9 | 2 | 6 | 3.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(N)=O)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 168475981 | 386245 | 3 | None | None | None | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 4.7 | O=C(O)c1c(-c2ccccc2)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5272962 | 386245 | 3 | None | None | None | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 4.7 | O=C(O)c1c(-c2ccccc2)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| 178294851 | 466751 | 0 | None | -33 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 1485 | 38 | 14 | 14 | 5.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | |||
| CHEMBL6160173 | 466751 | 0 | None | -33 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 1485 | 38 | 14 | 14 | 5.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | |||
| 11754586 | 216736 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 472 | 7 | 1 | 7 | 4.6 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| CHEMBL315881 | 216736 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 472 | 7 | 1 | 7 | 4.6 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| 1610 | 7967 | 67 | None | -1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| 3941 | 7967 | 67 | None | -1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| 3961 | 7967 | 67 | None | -1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL191 | 7967 | 67 | None | -1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| 5311345 | 6153 | 39 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1021/acs.jmedchem.9b01780 | |||
| 597 | 6153 | 39 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1021/acs.jmedchem.9b01780 | |||
| CHEMBL321820 | 6153 | 39 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 4.5 | OC(=O)[C@@H]1Cc2c(CN1C(=O)C(c1ccccc1)c1ccccc1)ncn2Cc1ccc(c(c1)C)N(C)C | 10.1021/acs.jmedchem.9b01780 | |||
| 9978737 | 237678 | 1 | None | None | None | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 407 | 10 | 3 | 5 | 4.3 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL342261 | 237678 | 1 | None | None | None | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 407 | 10 | 3 | 5 | 4.3 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL1076630 | 484417 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1156 | 33 | 14 | 13 | 1.3 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||
| 168289415 | 374379 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 527 | 8 | 1 | 9 | 4.8 | CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OC)s1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5191326 | 374379 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 527 | 8 | 1 | 9 | 4.8 | CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OC)s1 | 10.1016/j.bmc.2022.116790 | |||
| 44567849 | 372371 | 0 | None | None | None | Pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 488 | 11 | 1 | 5 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1cc(CC(C)C)ccc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL511490 | 372371 | 0 | None | None | None | Pig | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 488 | 11 | 1 | 5 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1cc(CC(C)C)ccc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 155520317 | 335040 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 527 | 12 | 3 | 5 | 6.3 | CCCCc1nc(Cl)c(CNC(=O)[C@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 155533580 | 335040 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 527 | 12 | 3 | 5 | 6.3 | CCCCc1nc(Cl)c(CNC(=O)[C@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4449166 | 335040 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 527 | 12 | 3 | 5 | 6.3 | CCCCc1nc(Cl)c(CNC(=O)[C@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4469350 | 335040 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 527 | 12 | 3 | 5 | 6.3 | CCCCc1nc(Cl)c(CNC(=O)[C@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 155523092 | 335359 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 527 | 12 | 3 | 5 | 6.1 | CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4453362 | 335359 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 527 | 12 | 3 | 5 | 6.1 | CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87219128 | 347008 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 541 | 14 | 3 | 5 | 6.6 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CCCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4515703 | 347008 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 541 | 14 | 3 | 5 | 6.6 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CCCC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218933 | 349106 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 555 | 14 | 3 | 5 | 6.9 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CCC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4568554 | 349106 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 555 | 14 | 3 | 5 | 6.9 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CCC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 10697700 | 473836 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 539 | 11 | 1 | 5 | 4.8 | CCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)C(=O)N2CCCC)cc1 | 10.1021/jm9904147 | |||
| CHEMBL90872 | 473836 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 539 | 11 | 1 | 5 | 4.8 | CCCCC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)C(=O)N2CCCC)cc1 | 10.1021/jm9904147 | |||
| CHEMBL4299329 | 478280 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1625 | 43 | 15 | 15 | 6.0 | CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL4302429 | 478280 | 0 | None | None | None | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 1625 | 43 | 15 | 15 | 6.0 | CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCCN1/C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@H](Cc1cnc[nH]1)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 45488134 | 394078 | 0 | None | None | None | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 490 | 8 | 1 | 7 | 5.2 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(CCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| CHEMBL566614 | 394078 | 0 | None | None | None | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 490 | 8 | 1 | 7 | 5.2 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(CCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| 1610 | 7967 | 67 | None | -2 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| 3941 | 7967 | 67 | None | -2 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| 3961 | 7967 | 67 | None | -2 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL191 | 7967 | 67 | None | -2 | 4 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1016/j.bmc.2016.03.028 | |||
| 10095683 | 240116 | 0 | None | -1 | 2 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL358359 | 240116 | 0 | None | -1 | 2 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 10095683 | 240116 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm010457z | |||
| CHEMBL358359 | 240116 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)CC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm010457z | |||
| 1610 | 7967 | 67 | None | -2 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00070a012 | |||
| 3941 | 7967 | 67 | None | -2 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00070a012 | |||
| 3961 | 7967 | 67 | None | -2 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00070a012 | |||
| CHEMBL191 | 7967 | 67 | None | -2 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/jm00070a012 | |||
| 44254496 | 19956 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 770 | 18 | 7 | 8 | 2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CN)C(C)C)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1021/jm900651p | |||
| CHEMBL1077582 | 19956 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 770 | 18 | 7 | 8 | 2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CN)C(C)C)C(=O)N[C@H]1Cc2ccccc2CN(CC(=O)N[C@@H](Cc2ccccc2)C(=O)O)C1=O | 10.1021/jm900651p | |||
| 44567819 | 367242 | 0 | None | None | None | Pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 488 | 11 | 1 | 5 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL481294 | 367242 | 0 | None | None | None | Pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 488 | 11 | 1 | 5 | 5.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 10094936 | 40719 | 0 | None | None | None | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00070a012 | |||
| CHEMBL124772 | 40719 | 0 | None | None | None | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 443 | 9 | 2 | 7 | 4.1 | CCCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00070a012 | |||
| 44475015 | 335986 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 75031588 | 335986 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218444 | 335986 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4463203 | 335986 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4464191 | 335986 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4535903 | 335986 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 155557693 | 348712 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 599 | 13 | 3 | 7 | 6.2 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4558883 | 348712 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 599 | 13 | 3 | 7 | 6.2 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 10504330 | 473757 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 464 | 5 | 1 | 5 | 4.4 | O=C1N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)N(c2ccccc2)C(=O)C12CCCC2 | 10.1021/jm9904147 | |||
| CHEMBL90411 | 473757 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 464 | 5 | 1 | 5 | 4.4 | O=C1N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)N(c2ccccc2)C(=O)C12CCCC2 | 10.1021/jm9904147 | |||
| 155535176 | 336557 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 625 | 13 | 3 | 5 | 7.9 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccc3ccccc3c2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4471668 | 336557 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 625 | 13 | 3 | 5 | 7.9 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccc3ccccc3c2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 46935636 | 202635 | 0 | None | -31622 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.9 | O=C(O)c1ccccc1-c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2013.09.004 | |||
| CHEMBL3040772 | 202635 | 0 | None | -31622 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 524 | 7 | 1 | 6 | 5.9 | O=C(O)c1ccccc1-c1ccc(CN2CCC(COC(=O)c3c4n(c5ccccc35)CCCO4)CC2)cc1 | 10.1016/j.bmc.2013.09.004 | |||
| 101783341 | 386177 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 391 | 4 | 1 | 4 | 4.6 | Cc1ccc(S(=O)(=O)n2c(-c3ccccc3)c(C(=O)O)c3ccccc32)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5271135 | 386177 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 391 | 4 | 1 | 4 | 4.6 | Cc1ccc(S(=O)(=O)n2c(-c3ccccc3)c(C(=O)O)c3ccccc32)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| 45488167 | 394248 | 0 | None | None | None | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 520 | 10 | 1 | 8 | 5.2 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| CHEMBL567898 | 394248 | 0 | None | None | None | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 520 | 10 | 1 | 8 | 5.2 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| 44567850 | 367287 | 0 | None | None | None | Pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 522 | 11 | 1 | 5 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL481664 | 367287 | 0 | None | None | None | Pig | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 522 | 11 | 1 | 5 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 1610 | 7967 | 67 | None | -1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| 3941 | 7967 | 67 | None | -1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| 3961 | 7967 | 67 | None | -1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL191 | 7967 | 67 | None | -1 | 4 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.5b01495 | |||
| 123794 | 7618 | 41 | None | None | None | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 1052 | 29 | 11 | 13 | 1.3 | CC[C@@H]([C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)c1cccnc1)Cc1ccc(cc1)O)CCCCNC(=O)[C@@H](NC(=O)OCc1ccccc1)CCCN=C(N)N)Cc1[nH]cnc1)C | 10.1021/acs.jmedchem.9b01780 | |||
| 594 | 7618 | 41 | None | None | None | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 1052 | 29 | 11 | 13 | 1.3 | CC[C@@H]([C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)c1cccnc1)Cc1ccc(cc1)O)CCCCNC(=O)[C@@H](NC(=O)OCc1ccccc1)CCCN=C(N)N)Cc1[nH]cnc1)C | 10.1021/acs.jmedchem.9b01780 | |||
| CHEMBL1885579 | 7618 | 41 | None | None | None | Rat | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 1052 | 29 | 11 | 13 | 1.3 | CC[C@@H]([C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)c1cccnc1)Cc1ccc(cc1)O)CCCCNC(=O)[C@@H](NC(=O)OCc1ccccc1)CCCN=C(N)N)Cc1[nH]cnc1)C | 10.1021/acs.jmedchem.9b01780 | |||
| CHEMBL1076601 | 484410 | 0 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 1097 | 28 | 10 | 12 | 2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||
| 168294859 | 375310 | 0 | None | -19 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 561 | 13 | 1 | 6 | 7.3 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCCC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5205769 | 375310 | 0 | None | -19 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 561 | 13 | 1 | 6 | 7.3 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCCC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 59984617 | 176228 | 0 | None | None | None | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 558 | 8 | 2 | 6 | 7.0 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccc(C(=O)O)cc2C(=O)O)cc1 | 10.1007/s00044-008-9153-9 | |||
| CHEMBL2260199 | 176228 | 0 | None | None | None | Rat | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 558 | 8 | 2 | 6 | 7.0 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccc(C(=O)O)cc2C(=O)O)cc1 | 10.1007/s00044-008-9153-9 | |||
| CHEMBL1076612 | 484414 | 0 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 1182 | 31 | 13 | 13 | 1.9 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccc(C(=O)c2ccccc2)cc1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||
| 87218987 | 335550 | 0 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 523 | 13 | 3 | 6 | 5.6 | CCCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4456519 | 335550 | 0 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 523 | 13 | 3 | 6 | 5.6 | CCCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 178298467 | 466518 | 0 | None | -104 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1414 | 32 | 13 | 16 | 2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)NC(=O)c1ccccc1-c1c2ccc(=[N+](C)C)cc-2oc2cc(N(C)C)ccc12)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | |||
| CHEMBL6147645 | 466518 | 0 | None | -104 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1414 | 32 | 13 | 16 | 2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)NC(=O)c1ccccc1-c1c2ccc(=[N+](C)C)cc-2oc2cc(N(C)C)ccc12)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | |||
| 178294851 | 466751 | 0 | None | -33 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1485 | 38 | 14 | 14 | 5.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | |||
| CHEMBL6160173 | 466751 | 0 | None | -33 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1485 | 38 | 14 | 14 | 5.6 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | |||
| 155516694 | 334673 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 507 | 12 | 3 | 5 | 5.9 | CCCCc1nc(C)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4443691 | 334673 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 507 | 12 | 3 | 5 | 5.9 | CCCCc1nc(C)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 10790260 | 473723 | 0 | None | None | None | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 463 | 8 | 2 | 4 | 4.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(C(=O)Nc2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| CHEMBL90187 | 473723 | 0 | None | None | None | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 463 | 8 | 2 | 4 | 4.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(C(=O)Nc2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| 1481 | 7955 | 73 | None | 8317 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm9904147 | |||
| 3749 | 7955 | 73 | None | 8317 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm9904147 | |||
| 6908 | 7955 | 73 | None | 8317 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm9904147 | |||
| CHEMBL1513 | 7955 | 73 | None | 8317 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm9904147 | |||
| 135723840 | 276475 | 0 | None | None | None | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL3787059 | 276475 | 0 | None | None | None | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 452 | 8 | 2 | 6 | 4.6 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| 3936 | 4506 | 37 | None | 1 | 4 | Pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| 6603900 | 4506 | 37 | None | 1 | 4 | Pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL288174 | 4506 | 37 | None | 1 | 4 | Pig | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2008.05.066 | |||
| 1481 | 7955 | 73 | None | 8317 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm010457z | |||
| 3749 | 7955 | 73 | None | 8317 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm010457z | |||
| 6908 | 7955 | 73 | None | 8317 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm010457z | |||
| CHEMBL1513 | 7955 | 73 | None | 8317 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 10.1021/jm010457z | |||
| 10005741 | 220951 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 488 | 7 | 2 | 7 | 4.5 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| CHEMBL327535 | 220951 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 488 | 7 | 2 | 7 | 4.5 | CCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| 10031067 | 200517 | 5 | None | -2 | 3 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL289614 | 200517 | 5 | None | -2 | 3 | Rat | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 576 | 11 | 1 | 7 | 6.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 127029976 | 276543 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787767 | 276543 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 1160 | 33 | 15 | 14 | -1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 10745817 | 238133 | 0 | None | None | None | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 580 | 12 | 3 | 7 | 5.4 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2Cl)cc1 | 10.1021/jm991050l | |||
| CHEMBL344464 | 238133 | 0 | None | None | None | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 580 | 12 | 3 | 7 | 5.4 | CCCCc1ncc(CNc2ccccc2C(=O)O)n1Cc1ccc(C(=O)NS(=O)(=O)c2ccccc2Cl)cc1 | 10.1021/jm991050l | |||
| 87219174 | 334334 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 537 | 14 | 3 | 6 | 5.9 | CCCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4438878 | 334334 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 537 | 14 | 3 | 6 | 5.9 | CCCOc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 44567745 | 367214 | 0 | None | None | None | Pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 480 | 10 | 2 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC(C)C)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL481089 | 367214 | 0 | None | None | None | Pig | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 480 | 10 | 2 | 6 | 5.0 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC(C)C)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 10345537 | 221098 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 492 | 6 | 2 | 8 | 4.0 | CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| CHEMBL328296 | 221098 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 492 | 6 | 2 | 8 | 4.0 | CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1 | 10.1021/jm00014a024 | |||
| 10481196 | 222223 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 503 | 6 | 2 | 7 | 4.9 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2cc(C(=O)O)ccc2n1 | 10.1021/jm00014a024 | |||
| CHEMBL330508 | 222223 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 503 | 6 | 2 | 7 | 4.9 | CCc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2cc(C(=O)O)ccc2n1 | 10.1021/jm00014a024 | |||
| 172198 | 866 | 40 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | |||
| 2504 | 866 | 40 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | |||
| 5272 | 866 | 40 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | |||
| CHEMBL408403 | 866 | 40 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | |||
| DB11842 | 866 | 40 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | |||
| P01015 | 866 | 40 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | |||
| P01019 | 866 | 40 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | |||
| P11859 | 866 | 40 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | |||
| 10432780 | 329446 | 0 | None | None | None | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 429 | 8 | 2 | 7 | 3.7 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00070a012 | |||
| CHEMBL421473 | 329446 | 0 | None | None | None | Rat | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 429 | 8 | 2 | 7 | 3.7 | CCCN(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)c1nc(C)ncc1C(=O)O | 10.1021/jm00070a012 | |||
| 127029977 | 276544 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787768 | 276544 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 1220 | 37 | 15 | 16 | -2.0 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCOCCOCCN)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 44325313 | 474332 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 480 | 6 | 2 | 8 | 4.3 | CCOC(=O)c1c(NCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)cc(C)nc1C | 10.1021/jm00014a024 | |||
| CHEMBL94106 | 474332 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 480 | 6 | 2 | 8 | 4.3 | CCOC(=O)c1c(NCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)cc(C)nc1C | 10.1021/jm00014a024 | |||
| 132404 | 238502 | 14 | None | 36 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 637 | 13 | 3 | 5 | 8.0 | CCCCCN(C(=O)NC)c1ccc2nc(CCCC)n(Cc3ccc(NC(=O)c4c(Cl)ccc(Cl)c4C(=O)O)cc3)c2c1 | 10.1021/jm9504722 | |||
| CHEMBL348126 | 238502 | 14 | None | 36 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 637 | 13 | 3 | 5 | 8.0 | CCCCCN(C(=O)NC)c1ccc2nc(CCCC)n(Cc3ccc(NC(=O)c4c(Cl)ccc(Cl)c4C(=O)O)cc3)c2c1 | 10.1021/jm9504722 | |||
| 15658054 | 473674 | 0 | None | None | None | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 429 | 8 | 2 | 8 | 3.7 | CCOC(=O)c1cnc(CC)nc1NCc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00070a012 | |||
| CHEMBL89877 | 473674 | 0 | None | None | None | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 429 | 8 | 2 | 8 | 3.7 | CCOC(=O)c1cnc(CC)nc1NCc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm00070a012 | |||
| 171347662 | 386281 | 0 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 455 | 7 | 1 | 5 | 5.0 | O=C(O)c1c(COCc2ccccc2)n(-c2ccc(S(=O)(=O)Cl)cc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5273768 | 386281 | 0 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 455 | 7 | 1 | 5 | 5.0 | O=C(O)c1c(COCc2ccccc2)n(-c2ccc(S(=O)(=O)Cl)cc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| 171344487 | 386208 | 0 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 321 | 5 | 1 | 3 | 4.4 | CCCCc1c(C(=O)O)c2ccccc2n1C(=O)c1ccccc1 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5271903 | 386208 | 0 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 321 | 5 | 1 | 3 | 4.4 | CCCCc1c(C(=O)O)c2ccccc2n1C(=O)c1ccccc1 | 10.1016/j.bmcl.2023.129349 | |||
| 178298467 | 466518 | 0 | None | -104 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1414 | 32 | 13 | 16 | 2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)NC(=O)c1ccccc1-c1c2ccc(=[N+](C)C)cc-2oc2cc(N(C)C)ccc12)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | |||
| CHEMBL6147645 | 466518 | 0 | None | -104 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 1414 | 32 | 13 | 16 | 2.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(=O)NC(=O)c1ccccc1-c1c2ccc(=[N+](C)C)cc-2oc2cc(N(C)C)ccc12)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | |||
| 11744384 | 65973 | 0 | None | None | None | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 448 | 11 | 3 | 6 | 5.2 | CCCCc1ncc(CNc2cc(N=[N+]=[N-])ccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| CHEMBL141065 | 65973 | 0 | None | None | None | Rat | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 448 | 11 | 3 | 6 | 5.2 | CCCCc1ncc(CNc2cc(N=[N+]=[N-])ccc2C(=O)O)n1Cc1ccc(C(=O)O)cc1 | 10.1021/jm991050l | |||
| 45488164 | 404605 | 0 | None | None | None | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 602 | 12 | 1 | 7 | 7.4 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)O)cc1 | 10.1021/jm901272d | |||
| CHEMBL572276 | 404605 | 0 | None | None | None | Rat | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 602 | 12 | 1 | 7 | 7.4 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)O)cc1 | 10.1021/jm901272d | |||
| 118719137 | 3131 | 0 | None | -4 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 1747 | 38 | 10 | 19 | 3.8 | [O-]C(=O)C(F)(F)F.[O-]C(=O)C(F)(F)F.[O-]C(=O)C(F)(F)F.CCN(c1ccc2c(c1)oc1c(c2c2ccc(cc2S(=O)(=O)O)S(=O)(=O)NCCCCCCCCCCCCNC(=O)NCCCCC(C(=O)NC(C(=O)NC2CC[NH+](CC2)C)Cc2cn(c[n+]2C)Cc2ccccc2)NC(=O)CC2=CSC(=N)[NH+]2C)ccc(=[N+](CC)CC)c1)CC | 10.1021/jm401789v | |||
| 6187 | 3131 | 0 | None | -4 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 1747 | 38 | 10 | 19 | 3.8 | [O-]C(=O)C(F)(F)F.[O-]C(=O)C(F)(F)F.[O-]C(=O)C(F)(F)F.CCN(c1ccc2c(c1)oc1c(c2c2ccc(cc2S(=O)(=O)O)S(=O)(=O)NCCCCCCCCCCCCNC(=O)NCCCCC(C(=O)NC(C(=O)NC2CC[NH+](CC2)C)Cc2cn(c[n+]2C)Cc2ccccc2)NC(=O)CC2=CSC(=N)[NH+]2C)ccc(=[N+](CC)CC)c1)CC | 10.1021/jm401789v | |||
| 73755182 | 3131 | 0 | None | -4 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 1747 | 38 | 10 | 19 | 3.8 | [O-]C(=O)C(F)(F)F.[O-]C(=O)C(F)(F)F.[O-]C(=O)C(F)(F)F.CCN(c1ccc2c(c1)oc1c(c2c2ccc(cc2S(=O)(=O)O)S(=O)(=O)NCCCCCCCCCCCCNC(=O)NCCCCC(C(=O)NC(C(=O)NC2CC[NH+](CC2)C)Cc2cn(c[n+]2C)Cc2ccccc2)NC(=O)CC2=CSC(=N)[NH+]2C)ccc(=[N+](CC)CC)c1)CC | 10.1021/jm401789v | |||
| CHEMBL3350781 | 3131 | 0 | None | -4 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 1747 | 38 | 10 | 19 | 3.8 | [O-]C(=O)C(F)(F)F.[O-]C(=O)C(F)(F)F.[O-]C(=O)C(F)(F)F.CCN(c1ccc2c(c1)oc1c(c2c2ccc(cc2S(=O)(=O)O)S(=O)(=O)NCCCCCCCCCCCCNC(=O)NCCCCC(C(=O)NC(C(=O)NC2CC[NH+](CC2)C)Cc2cn(c[n+]2C)Cc2ccccc2)NC(=O)CC2=CSC(=N)[NH+]2C)ccc(=[N+](CC)CC)c1)CC | 10.1021/jm401789v | |||
| 171352781 | 386637 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 345 | 4 | 2 | 5 | 2.4 | Cc1ccc(S(=O)(=O)n2c(CO)c(C(=O)O)c3ccccc32)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5282200 | 386637 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 345 | 4 | 2 | 5 | 2.4 | Cc1ccc(S(=O)(=O)n2c(CO)c(C(=O)O)c3ccccc32)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| 132840 | 215182 | 27 | None | 3311 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 426 | 6 | 2 | 8 | 3.5 | CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL312104 | 215182 | 27 | None | 3311 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 426 | 6 | 2 | 8 | 3.5 | CCCc1nc(C)n2nc(O)nc2c1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 171354030 | 386429 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 359 | 6 | 1 | 5 | 2.9 | CS(=O)(=O)n1c(COCc2ccccc2)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5277518 | 386429 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 359 | 6 | 1 | 5 | 2.9 | CS(=O)(=O)n1c(COCc2ccccc2)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL1076602 | 484411 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 1101 | 27 | 10 | 13 | 2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||
| 145957579 | 317805 | 0 | None | None | None | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 497 | 7 | 0 | 3 | 7.0 | CCCCC1=N/C(=C\c2ccc(Br)cc2)C(=O)N1Cc1ccc(-c2ccccc2C#N)cc1 | 10.1016/j.ejmech.2017.12.021 | |||
| CHEMBL4164514 | 317805 | 0 | None | None | None | Human | 4.6 | pKi | = | 4.6 | Binding | ChEMBL | 497 | 7 | 0 | 3 | 7.0 | CCCCC1=N/C(=C\c2ccc(Br)cc2)C(=O)N1Cc1ccc(-c2ccccc2C#N)cc1 | 10.1016/j.ejmech.2017.12.021 | |||
| 5249743 | 216678 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 5 | 4.0 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL315444 | 216678 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 5 | 4.0 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm9904147 | |||
| 10674630 | 473773 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 573 | 10 | 1 | 5 | 5.3 | CCCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL90483 | 473773 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 573 | 10 | 1 | 5 | 5.3 | CCCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| 5249743 | 216678 | 0 | None | -1 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 5 | 4.0 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL315444 | 216678 | 0 | None | -1 | 2 | Rat | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 5 | 4.0 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 53317942 | 120393 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 7 | 3.3 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1667999 | 120393 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 7 | 3.3 | CCCCN1CC2(CN1Cc1ccc(-c3ccccc3-c3nnn[nH]3)cc1)C(=O)CCC2=O | 10.1016/j.bmc.2010.10.043 | |||
| 5249743 | 216678 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 5 | 4.0 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm010457z | |||
| CHEMBL315444 | 216678 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 444 | 7 | 1 | 5 | 4.0 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm010457z | |||
| CHEMBL312754 | 484256 | 17 | None | -4 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 926 | 26 | 12 | 12 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | 10.1021/acs.jmedchem.4c01693 | |||
| 87218826 | 336622 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 581 | 13 | 3 | 5 | 7.4 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CCCCC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4472489 | 336622 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 581 | 13 | 3 | 5 | 7.4 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CCCCC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 45488163 | 404545 | 0 | None | None | None | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 630 | 13 | 0 | 8 | 7.9 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)OCC)cc1 | 10.1021/jm901272d | |||
| CHEMBL571763 | 404545 | 0 | None | None | None | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 630 | 13 | 0 | 8 | 7.9 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1CCOc1ccc(CC(C)(Oc2ccccc2)C(=O)OCC)cc1 | 10.1021/jm901272d | |||
| 163409136 | 373977 | 3 | None | 18 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 583 | 11 | 1 | 9 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5185088 | 373977 | 3 | None | 18 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 583 | 11 | 1 | 9 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 171351414 | 386937 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 269 | 3 | 2 | 5 | 0.6 | CS(=O)(=O)n1c(CO)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5289070 | 386937 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 269 | 3 | 2 | 5 | 0.6 | CS(=O)(=O)n1c(CO)c(C(=O)O)c2ccccc21 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL1076613 | 484415 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 1186 | 30 | 13 | 14 | 1.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||
| CHEMBL312754 | 484256 | 17 | None | -4 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 926 | 26 | 12 | 12 | -2.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | 10.1021/acs.jmedchem.4c01693 | |||
| 132603300 | 386369 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 371 | 6 | 1 | 4 | 4.2 | CCCCc1c(C(=O)O)c2ccccc2n1S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5275739 | 386369 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 371 | 6 | 1 | 4 | 4.2 | CCCCc1c(C(=O)O)c2ccccc2n1S(=O)(=O)c1ccc(C)cc1 | 10.1016/j.bmcl.2023.129349 | |||
| 168295859 | 375319 | 0 | None | 50 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 569 | 11 | 1 | 9 | 6.0 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5205969 | 375319 | 0 | None | 50 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 569 | 11 | 1 | 9 | 6.0 | CCCCOC(=O)NS(=O)(=O)c1sc(CCC)nc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc32)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 171347856 | 386880 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 295 | 5 | 1 | 4 | 2.5 | CCCCc1c(C(=O)O)c2ccccc2n1S(C)(=O)=O | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5287876 | 386880 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 295 | 5 | 1 | 4 | 2.5 | CCCCc1c(C(=O)O)c2ccccc2n1S(C)(=O)=O | 10.1016/j.bmcl.2023.129349 | |||
| 45488125 | 394247 | 0 | None | None | None | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 360 | 7 | 1 | 5 | 3.6 | CCCc1nc2c(C)cccc2n1Cc1ccc(CCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| CHEMBL567897 | 394247 | 0 | None | None | None | Rat | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 360 | 7 | 1 | 5 | 3.6 | CCCc1nc2c(C)cccc2n1Cc1ccc(CCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| 10742620 | 120397 | 0 | None | 16 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 460 | 7 | 2 | 6 | 5.1 | CCCc1nc2ccccc2n1C(F)(F)C(O)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| CHEMBL1668003 | 120397 | 0 | None | 16 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 460 | 7 | 2 | 6 | 5.1 | CCCc1nc2ccccc2n1C(F)(F)C(O)c1ccc(-c2ccccc2-c2nnn[nH]2)cc1 | 10.1016/j.bmc.2010.10.043 | |||
| 131590 | 44552 | 36 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm9504722 | |||
| CHEMBL130896 | 44552 | 36 | None | 1 | 3 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm9504722 | |||
| 131590 | 44552 | 36 | None | -1 | 3 | Rabbit | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00052a006 | |||
| CHEMBL130896 | 44552 | 36 | None | -1 | 3 | Rabbit | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 524 | 9 | 3 | 4 | 7.2 | CCCCc1nc2ccc(NC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm00052a006 | |||
| 44567851 | 367137 | 0 | None | None | None | Pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 522 | 11 | 1 | 5 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1cc(Cc2ccccc2)ccc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL480506 | 367137 | 0 | None | None | None | Pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 522 | 11 | 1 | 5 | 5.6 | CCCCOC(=O)NS(=O)(=O)c1cc(Cc2ccccc2)ccc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 24755620 | 8610 | 72 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.ejmech.2017.12.021 | |||
| 2806 | 8610 | 72 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.ejmech.2017.12.021 | |||
| 3937 | 8610 | 72 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.ejmech.2017.12.021 | |||
| 5284633 | 8610 | 72 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.ejmech.2017.12.021 | |||
| 60846 | 8610 | 72 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.ejmech.2017.12.021 | |||
| CHEMBL1069 | 8610 | 72 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.ejmech.2017.12.021 | |||
| CHEMBL115622 | 8610 | 72 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.ejmech.2017.12.021 | |||
| CHEMBL5315276 | 8610 | 72 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.ejmech.2017.12.021 | |||
| DB00177 | 8610 | 72 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1016/j.ejmech.2017.12.021 | |||
| 25141238 | 375569 | 0 | None | None | None | Pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 494 | 11 | 1 | 6 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL521093 | 375569 | 0 | None | None | None | Pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 494 | 11 | 1 | 6 | 5.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 127031545 | 276524 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787701 | 276524 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1276 | 39 | 15 | 16 | -1.4 | CCC(=O)NCCOCCOCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC)C(C)C | 10.1021/acs.jmedchem.5b01495 | |||
| 136093942 | 276430 | 0 | None | None | None | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 436 | 8 | 1 | 6 | 4.8 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL3786570 | 276430 | 0 | None | None | None | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 436 | 8 | 1 | 6 | 4.8 | CCCCc1nc(Cl)c(C=O)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| 44567817 | 366403 | 0 | None | None | None | Pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 506 | 9 | 1 | 6 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCCCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL479399 | 366403 | 0 | None | None | None | Pig | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 506 | 9 | 1 | 6 | 5.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCCCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 172198 | 866 | 40 | None | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | |||
| 2504 | 866 | 40 | None | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | |||
| 5272 | 866 | 40 | None | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | |||
| CHEMBL408403 | 866 | 40 | None | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | |||
| DB11842 | 866 | 40 | None | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | |||
| P01015 | 866 | 40 | None | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | |||
| P01019 | 866 | 40 | None | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | |||
| P11859 | 866 | 40 | None | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | 10.1021/acs.jmedchem.4c01693 | |||
| 2541 | 7891 | 68 | None | -9 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 6907 | 7891 | 68 | None | -9 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL1016 | 7891 | 68 | None | -9 | 5 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL1076631 | 484418 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 1160 | 32 | 14 | 14 | 1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||
| 10096683 | 474013 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 480 | 6 | 2 | 8 | 4.4 | CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1 | 10.1021/jm00014a024 | |||
| CHEMBL91928 | 474013 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 480 | 6 | 2 | 8 | 4.4 | CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1 | 10.1021/jm00014a024 | |||
| 3936 | 4506 | 37 | None | -1 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.ejmech.2023.115762 | |||
| 6603900 | 4506 | 37 | None | -1 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.ejmech.2023.115762 | |||
| CHEMBL288174 | 4506 | 37 | None | -1 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.ejmech.2023.115762 | |||
| 3936 | 4506 | 37 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/acs.jmedchem.9b01780 | |||
| 6603900 | 4506 | 37 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/acs.jmedchem.9b01780 | |||
| CHEMBL288174 | 4506 | 37 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1021/acs.jmedchem.9b01780 | |||
| 3936 | 4506 | 37 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| 6603900 | 4506 | 37 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL288174 | 4506 | 37 | None | -1 | 4 | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 582 | 11 | 1 | 8 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1sc(cc1c1ccc(cc1)Cn1c(CC)nc2c1nc(C)cc2C)CC(C)C | 10.1016/j.bmc.2022.116790 | |||
| 171348584 | 386717 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 295 | 3 | 2 | 4 | 2.5 | O=C(O)c1c(CO)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5283862 | 386717 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 295 | 3 | 2 | 4 | 2.5 | O=C(O)c1c(CO)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| 171353965 | 386383 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 385 | 6 | 1 | 4 | 4.7 | O=C(O)c1c(COCc2ccccc2)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| CHEMBL5276125 | 386383 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 385 | 6 | 1 | 4 | 4.7 | O=C(O)c1c(COCc2ccccc2)n(C(=O)c2ccccc2)c2ccccc12 | 10.1016/j.bmcl.2023.129349 | |||
| 44567781 | 367055 | 0 | None | None | None | Pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 542 | 11 | 1 | 6 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(C)Cc2ccccc2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL480340 | 367055 | 0 | None | None | None | Pig | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 542 | 11 | 1 | 6 | 6.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(C)Cc2ccccc2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL1076664 | 484423 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 1116 | 30 | 12 | 12 | 1.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||
| 155526996 | 335681 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 549 | 14 | 3 | 5 | 6.8 | CCCCc1nc(CC(C)C)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4458466 | 335681 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 549 | 14 | 3 | 5 | 6.8 | CCCCc1nc(CC(C)C)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218835 | 335725 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 539 | 13 | 3 | 5 | 6.3 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4459070 | 335725 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 539 | 13 | 3 | 5 | 6.3 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 155552503 | 348231 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 533 | 13 | 3 | 5 | 6.5 | CCCCc1nc(C2CC2)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4547120 | 348231 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 533 | 13 | 3 | 5 | 6.5 | CCCCc1nc(C2CC2)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 10764613 | 473842 | 0 | None | None | None | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 420 | 7 | 1 | 3 | 4.5 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| CHEMBL90887 | 473842 | 0 | None | None | None | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 420 | 7 | 1 | 3 | 4.5 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| 145952582 | 327991 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 782 | 12 | 0 | 6 | 10.6 | CCCCC1=N/C(=C\c2ccccc2Br)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn(C(c3ccccc3)(c3ccccc3)c3ccccc3)n2)cc1 | 10.1016/j.ejmech.2017.12.021 | |||
| CHEMBL4175147 | 327991 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 782 | 12 | 0 | 6 | 10.6 | CCCCC1=N/C(=C\c2ccccc2Br)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn(C(c3ccccc3)(c3ccccc3)c3ccccc3)n2)cc1 | 10.1016/j.ejmech.2017.12.021 | |||
| 10507383 | 215789 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 575 | 12 | 1 | 5 | 5.6 | CCCCN1C(=O)C(C)(CCCC)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL313392 | 215789 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 575 | 12 | 1 | 5 | 5.6 | CCCCN1C(=O)C(C)(CCCC)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| 11801362 | 216733 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 580 | 9 | 2 | 5 | 5.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC2CCCCC2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL315873 | 216733 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 580 | 9 | 2 | 5 | 5.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)NC2CCCCC2)cc1 | 10.1021/jm9904147 | |||
| 10765881 | 473841 | 0 | None | None | None | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 448 | 8 | 1 | 4 | 4.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(C(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| CHEMBL90885 | 473841 | 0 | None | None | None | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 448 | 8 | 1 | 4 | 4.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(C(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| 44567818 | 367215 | 0 | None | None | None | Pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 4.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCOCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL481106 | 367215 | 0 | None | None | None | Pig | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 508 | 9 | 1 | 7 | 4.3 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCOCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 44567744 | 367213 | 0 | None | None | None | Pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 466 | 9 | 1 | 6 | 4.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(C)C)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL481088 | 367213 | 0 | None | None | None | Pig | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 466 | 9 | 1 | 6 | 4.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N(C)C)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 44312565 | 469654 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 437 | 9 | 3 | 6 | 3.1 | CC(O)CCC(=O)N(c1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)O)C(C)C | 10.1021/jm0204237 | |||
| CHEMBL74767 | 469654 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 437 | 9 | 3 | 6 | 3.1 | CC(O)CCC(=O)N(c1ccc(-c2ccccc2-c2nn[nH]n2)cc1)[C@H](C(=O)O)C(C)C | 10.1021/jm0204237 | |||
| 9872676 | 159773 | 0 | None | -9332 | 17 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 565 | 11 | 2 | 10 | 4.8 | COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 | 10.1021/jm060012g | |||
| CHEMBL210514 | 159773 | 0 | None | -9332 | 17 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 565 | 11 | 2 | 10 | 4.8 | COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 | 10.1021/jm060012g | |||
| 10790818 | 473855 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 478 | 5 | 1 | 5 | 4.7 | Cc1ccc(N2C(=O)C3(CCCC3)C(=O)N2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL90999 | 473855 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 478 | 5 | 1 | 5 | 4.7 | Cc1ccc(N2C(=O)C3(CCCC3)C(=O)N2Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)cc1 | 10.1021/jm9904147 | |||
| 87218678 | 334889 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 521 | 13 | 3 | 5 | 6.2 | CCCCc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4447138 | 334889 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 521 | 13 | 3 | 5 | 6.2 | CCCCc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 44475015 | 335986 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 75031588 | 335986 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218444 | 335986 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4463203 | 335986 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4464191 | 335986 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4535903 | 335986 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)[C@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 168274602 | 373466 | 0 | None | -97 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 547 | 11 | 1 | 6 | 7.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5177359 | 373466 | 0 | None | -97 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 547 | 11 | 1 | 6 | 7.0 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C(C)C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 10695405 | 473479 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 463 | 8 | 2 | 4 | 4.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| CHEMBL88471 | 473479 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 463 | 8 | 2 | 4 | 4.1 | CCCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(NC(=O)c2ccccc2C(=O)O)cc1 | 10.1021/jm9904147 | |||
| 155522135 | 335203 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 651 | 14 | 3 | 5 | 8.4 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4451425 | 335203 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 651 | 14 | 3 | 5 | 8.4 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccc(-c3ccccc3)cc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218371 | 347757 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 625 | 13 | 3 | 5 | 7.9 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2cccc3ccccc23)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4534876 | 347757 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 625 | 13 | 3 | 5 | 7.9 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2cccc3ccccc23)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 10095241 | 220971 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 449 | 4 | 1 | 6 | 4.7 | Cc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2c(n1)CCCC2 | 10.1021/jm00014a024 | |||
| CHEMBL327633 | 220971 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 449 | 4 | 1 | 6 | 4.7 | Cc1cc(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)c2c(n1)CCCC2 | 10.1021/jm00014a024 | |||
| 10028164 | 222056 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 481 | 6 | 1 | 8 | 4.3 | CCOC(=O)c1c(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)cc(C)nc1C | 10.1021/jm00014a024 | |||
| CHEMBL330109 | 222056 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 481 | 6 | 1 | 8 | 4.3 | CCOC(=O)c1c(OCc2ccc3c(-c4nnn[nH]4)cc4ccccc4c(=O)c3c2)cc(C)nc1C | 10.1021/jm00014a024 | |||
| 135723852 | 276473 | 0 | None | None | None | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| CHEMBL3787050 | 276473 | 0 | None | None | None | Rat | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 438 | 8 | 2 | 6 | 4.4 | CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1 | 10.1016/j.bmc.2016.03.028 | |||
| 10697829 | 474055 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 545 | 8 | 1 | 5 | 4.5 | CCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL92225 | 474055 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 545 | 8 | 1 | 5 | 4.5 | CCCN1C(=O)C2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| 168290795 | 374992 | 0 | None | -33 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 559 | 11 | 1 | 6 | 7.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5200734 | 374992 | 0 | None | -33 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 559 | 11 | 1 | 6 | 7.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 10790819 | 220963 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 478 | 6 | 1 | 5 | 4.4 | O=C1N(Cc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)C12CCCC2 | 10.1021/jm9904147 | |||
| CHEMBL327594 | 220963 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 478 | 6 | 1 | 5 | 4.4 | O=C1N(Cc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)C12CCCC2 | 10.1021/jm9904147 | |||
| 44567852 | 367138 | 0 | None | None | None | Pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 432 | 9 | 1 | 5 | 4.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL480507 | 367138 | 0 | None | None | None | Pig | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 432 | 9 | 1 | 5 | 4.1 | CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 123814 | 870 | 31 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 774 | 19 | 8 | 9 | 1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm701490g | |||
| 5368 | 870 | 31 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 774 | 19 | 8 | 9 | 1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm701490g | |||
| CHEMBL261120 | 870 | 31 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 774 | 19 | 8 | 9 | 1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm701490g | |||
| P01015 | 870 | 31 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 774 | 19 | 8 | 9 | 1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm701490g | |||
| P01019 | 870 | 31 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 774 | 19 | 8 | 9 | 1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm701490g | |||
| P11859 | 870 | 31 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 774 | 19 | 8 | 9 | 1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm701490g | |||
| 123814 | 870 | 31 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 774 | 19 | 8 | 9 | 1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm900651p | |||
| 5368 | 870 | 31 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 774 | 19 | 8 | 9 | 1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm900651p | |||
| CHEMBL261120 | 870 | 31 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 774 | 19 | 8 | 9 | 1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm900651p | |||
| P01015 | 870 | 31 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 774 | 19 | 8 | 9 | 1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm900651p | |||
| P01019 | 870 | 31 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 774 | 19 | 8 | 9 | 1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm900651p | |||
| P11859 | 870 | 31 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 774 | 19 | 8 | 9 | 1.2 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm900651p | |||
| 168279676 | 374200 | 0 | None | -11 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 573 | 11 | 1 | 6 | 7.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5188126 | 374200 | 0 | None | -11 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 573 | 11 | 1 | 6 | 7.6 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CCCC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 10744859 | 473547 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 533 | 9 | 1 | 5 | 4.4 | CCCCN1C(=O)C(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| CHEMBL88924 | 473547 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 533 | 9 | 1 | 5 | 4.4 | CCCCN1C(=O)C(C)(C)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)cc1 | 10.1021/jm9904147 | |||
| 168287840 | 374372 | 0 | None | -32 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 547 | 12 | 1 | 6 | 6.9 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5191241 | 374372 | 0 | None | -32 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 547 | 12 | 1 | 6 | 6.9 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CCC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 24755620 | 8610 | 72 | None | None | None | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm0204237 | |||
| 2806 | 8610 | 72 | None | None | None | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm0204237 | |||
| 3937 | 8610 | 72 | None | None | None | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm0204237 | |||
| 5284633 | 8610 | 72 | None | None | None | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm0204237 | |||
| 60846 | 8610 | 72 | None | None | None | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm0204237 | |||
| CHEMBL1069 | 8610 | 72 | None | None | None | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm0204237 | |||
| CHEMBL115622 | 8610 | 72 | None | None | None | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm0204237 | |||
| CHEMBL5315276 | 8610 | 72 | None | None | None | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm0204237 | |||
| DB00177 | 8610 | 72 | None | None | None | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 10.1021/jm0204237 | |||
| 1610 | 7967 | 67 | None | -1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acsmedchemlett.8b00462 | |||
| 3941 | 7967 | 67 | None | -1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acsmedchemlett.8b00462 | |||
| 3961 | 7967 | 67 | None | -1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL191 | 7967 | 67 | None | -1 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acsmedchemlett.8b00462 | |||
| 87218492 | 335450 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 535 | 14 | 3 | 5 | 6.4 | CCCCc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4454778 | 335450 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 535 | 14 | 3 | 5 | 6.4 | CCCCc1nc(CC)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218698 | 336813 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 527 | 12 | 3 | 6 | 5.4 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)c(F)c1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4474870 | 336813 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 527 | 12 | 3 | 6 | 5.4 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)c(F)c1 | 10.1021/acsmedchemlett.8b00462 | |||
| 25190005 | 348104 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 545 | 12 | 3 | 6 | 5.5 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1cc(F)c(-c2ccccc2C(=O)O)cc1F | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4543532 | 348104 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 545 | 12 | 3 | 6 | 5.5 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1cc(F)c(-c2ccccc2C(=O)O)cc1F | 10.1021/acsmedchemlett.8b00462 | |||
| 155529942 | 336013 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 569 | 15 | 3 | 5 | 7.3 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC(CC)CC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4463575 | 336013 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 569 | 15 | 3 | 5 | 7.3 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC(CC)CC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 155547799 | 347773 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 521 | 13 | 3 | 5 | 6.2 | CCCCc1nc(C)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4535256 | 347773 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 521 | 13 | 3 | 5 | 6.2 | CCCCc1nc(C)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218352 | 348473 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 567 | 13 | 3 | 5 | 7.0 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CCCC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4552884 | 348473 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 567 | 13 | 3 | 5 | 7.0 | CCCCc1nc(Cl)c(CNC(=O)C(CS)CC2CCCC2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 45488150 | 394118 | 0 | None | None | None | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 362 | 7 | 1 | 6 | 3.4 | CCCc1nc2c(C)cccc2n1Cc1ccc(OCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| CHEMBL567054 | 394118 | 0 | None | None | None | Rat | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 362 | 7 | 1 | 6 | 3.4 | CCCc1nc2c(C)cccc2n1Cc1ccc(OCc2nnn[nH]2)cc1 | 10.1021/jm901272d | |||
| 178295794 | 466346 | 0 | None | -1412 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 1365 | 34 | 12 | 13 | 4.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | 10.1021/acs.jmedchem.4c01693 | |||
| CHEMBL6143072 | 466346 | 0 | None | -1412 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 1365 | 34 | 12 | 13 | 4.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | 10.1021/acs.jmedchem.4c01693 | |||
| 25141240 | 366927 | 0 | None | None | None | Pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 508 | 10 | 1 | 5 | 5.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(-c2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL480122 | 366927 | 0 | None | None | None | Pig | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 508 | 10 | 1 | 5 | 5.7 | CCCCOC(=O)NS(=O)(=O)c1ccc(-c2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 178295794 | 466346 | 0 | None | -1412 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 1365 | 34 | 12 | 13 | 4.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | 10.1021/acs.jmedchem.4c01693 | |||
| CHEMBL6143072 | 466346 | 0 | None | -1412 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 1365 | 34 | 12 | 13 | 4.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CN(C)C(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O | 10.1021/acs.jmedchem.4c01693 | |||
| 42611190 | 6416 | 21 | None | -13803 | 23 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL4507292 | |||
| 5802 | 6416 | 21 | None | -13803 | 23 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL4507292 | |||
| CHEMBL1800685 | 6416 | 21 | None | -13803 | 23 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL4507292 | |||
| 24828743 | 196521 | 0 | None | None | None | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 788 | 20 | 8 | 9 | 1.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CN)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm701490g | |||
| CHEMBL260622 | 196521 | 0 | None | None | None | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 788 | 20 | 8 | 9 | 1.4 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CN)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm701490g | |||
| CHEMBL1076629 | 484416 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 1120 | 29 | 12 | 13 | 1.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC)C(C)C)C(=O)N[C@@H](Cc1ccc(C2(C(F)(F)F)N=N2)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm9015747 | |||
| 87218658 | 335553 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 547 | 14 | 3 | 5 | 6.7 | CCCCc1nc(C2CC2)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4456544 | 335553 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 547 | 14 | 3 | 5 | 6.7 | CCCCc1nc(C2CC2)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87219028 | 336134 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 509 | 12 | 3 | 6 | 5.2 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4465325 | 336134 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 509 | 12 | 3 | 6 | 5.2 | CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 44567816 | 373438 | 0 | None | None | None | Pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 492 | 9 | 1 | 6 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL517685 | 373438 | 0 | None | None | None | Pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 492 | 9 | 1 | 6 | 5.1 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)N2CCCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 44567780 | 375219 | 0 | None | None | None | Pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 520 | 10 | 2 | 6 | 5.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC2CCCCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL520421 | 375219 | 0 | None | None | None | Pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 520 | 10 | 2 | 6 | 5.9 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(C(=O)NC2CCCCC2)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 178312143 | 466237 | 0 | None | -229 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 1644 | 47 | 15 | 17 | 5.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CCOCCOCCNC(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | |||
| CHEMBL6133895 | 466237 | 0 | None | -229 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 1644 | 47 | 15 | 17 | 5.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CCOCCOCCNC(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | |||
| 168275495 | 373558 | 0 | None | -66 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 519 | 10 | 1 | 6 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5178838 | 373558 | 0 | None | -66 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 519 | 10 | 1 | 6 | 6.2 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 155520317 | 335040 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 527 | 12 | 3 | 5 | 6.3 | CCCCc1nc(Cl)c(CNC(=O)[C@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 155533580 | 335040 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 527 | 12 | 3 | 5 | 6.3 | CCCCc1nc(Cl)c(CNC(=O)[C@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4449166 | 335040 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 527 | 12 | 3 | 5 | 6.3 | CCCCc1nc(Cl)c(CNC(=O)[C@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4469350 | 335040 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 527 | 12 | 3 | 5 | 6.3 | CCCCc1nc(Cl)c(CNC(=O)[C@H](S)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 87218397 | 335694 | 0 | None | None | None | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)CC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4458683 | 335694 | 0 | None | None | None | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 541 | 13 | 3 | 5 | 6.5 | CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)CC)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 178312143 | 466237 | 0 | None | -229 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 1644 | 47 | 15 | 17 | 5.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CCOCCOCCNC(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | |||
| CHEMBL6133895 | 466237 | 0 | None | -229 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 1644 | 47 | 15 | 17 | 5.1 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)CCOCCOCCNC(=O)CCCCCN1/C(=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)C(C)(C)c2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.4c01693 | |||
| 10077050 | 176227 | 0 | None | None | None | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 586 | 8 | 0 | 8 | 7.1 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccc(C(=O)OC)cc2C(=O)OC)cc1 | 10.1007/s00044-008-9153-9 | |||
| CHEMBL2260198 | 176227 | 0 | None | None | None | Rat | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 586 | 8 | 0 | 8 | 7.1 | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccc(C(=O)OC)cc2C(=O)OC)cc1 | 10.1007/s00044-008-9153-9 | |||
| 15657894 | 474017 | 0 | None | None | None | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 401 | 7 | 3 | 7 | 3.2 | CCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00070a012 | |||
| CHEMBL91953 | 474017 | 0 | None | None | None | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 401 | 7 | 3 | 7 | 3.2 | CCc1ncc(C(=O)O)c(NCc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)n1 | 10.1021/jm00070a012 | |||
| 9805192 | 181771 | 0 | None | None | None | Pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 480 | 10 | 1 | 6 | 4.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CC(=O)N(C)C)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL239393 | 181771 | 0 | None | None | None | Pig | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 480 | 10 | 1 | 6 | 4.5 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CC(=O)N(C)C)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 1610 | 7967 | 67 | None | -1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.4c01693 | |||
| 3941 | 7967 | 67 | None | -1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.4c01693 | |||
| 3961 | 7967 | 67 | None | -1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.4c01693 | |||
| CHEMBL191 | 7967 | 67 | None | -1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.4c01693 | |||
| 1610 | 7967 | 67 | None | -1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.4c01693 | |||
| 3941 | 7967 | 67 | None | -1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.4c01693 | |||
| 3961 | 7967 | 67 | None | -1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.4c01693 | |||
| CHEMBL191 | 7967 | 67 | None | -1 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 10.1021/acs.jmedchem.4c01693 | |||
| 155512629 | 334222 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 563 | 15 | 3 | 5 | 7.0 | CCCCc1nc(CC(C)C)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4437331 | 334222 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 563 | 15 | 3 | 5 | 7.0 | CCCCc1nc(CC(C)C)c(CNC(=O)[C@@H](CS)CC(C)C)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 168270996 | 373156 | 0 | None | -64 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 533 | 11 | 1 | 6 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5172324 | 373156 | 0 | None | -64 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 533 | 11 | 1 | 6 | 6.5 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(CC)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 168287782 | 374876 | 0 | None | -22 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 545 | 11 | 1 | 6 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| CHEMBL5198739 | 374876 | 0 | None | -22 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 545 | 11 | 1 | 6 | 6.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(CCC)cc1-c1ccc(Cn2c(C3CC3)nc3ccccc32)cc1 | 10.1016/j.bmc.2022.116804 | |||
| 155513439 | 334299 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 589 | 13 | 3 | 5 | 7.3 | CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)c2ccccc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4438435 | 334299 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 589 | 13 | 3 | 5 | 7.3 | CCCCc1nc(Cl)c(CNC(=O)C(CS)C(C)c2ccccc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 155565351 | 349572 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 575 | 13 | 3 | 5 | 6.7 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| CHEMBL4579452 | 349572 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 575 | 13 | 3 | 5 | 6.7 | CCCCc1nc(Cl)c(CNC(=O)C(CS)Cc2ccccc2)n1Cc1ccc(-c2ccccc2C(=O)O)cc1 | 10.1021/acsmedchemlett.8b00462 | |||
| 163409135 | 373278 | 4 | None | 37 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 623 | 11 | 1 | 9 | 6.5 | CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5174180 | 373278 | 4 | None | 37 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 623 | 11 | 1 | 9 | 6.5 | CCCc1nc(-c2ccc(Cn3c(CC)nc4c(C)cc(C)nc43)cc2)c(S(=O)(=O)NC(=O)OCCCC(F)(F)F)s1 | 10.1016/j.bmc.2022.116790 | |||
| 10254899 | 473830 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 487 | 9 | 2 | 6 | 4.2 | CCCCC(=O)N(Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1)[C@H](C(=O)O)C(C)C | 10.1021/jm00014a024 | |||
| CHEMBL90834 | 473830 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 487 | 9 | 2 | 6 | 4.2 | CCCCC(=O)N(Cc1ccc2c(-c3nnn[nH]3)cc3ccccc3c(=O)c2c1)[C@H](C(=O)O)C(C)C | 10.1021/jm00014a024 | |||
| 11488492 | 193918 | 0 | None | None | None | Pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 480 | 10 | 1 | 6 | 4.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CN(C)C(C)=O)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL246255 | 193918 | 0 | None | None | None | Pig | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 480 | 10 | 1 | 6 | 4.8 | CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1-c1ccc(CN(C)C(C)=O)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 10884983 | 81759 | 0 | None | -1 | 2 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)C2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| CHEMBL146275 | 81759 | 0 | None | -1 | 2 | Rat | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)C2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm7011563 | |||
| 10884983 | 81759 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)C2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm010457z | |||
| CHEMBL146275 | 81759 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 458 | 7 | 1 | 5 | 4.4 | CCCCN1C(=O)C2(CCCC2)CC(=O)N1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | 10.1021/jm010457z | |||
| 127034038 | 276525 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 1656 | 46 | 15 | 20 | 2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| CHEMBL3787702 | 276525 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 1656 | 46 | 15 | 20 | 2.5 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN/C(N)=N/C(=O)NCCCCNC(=O)CCCCC[n+]1cc(S(=O)(=O)[O-])ccc1/C=C/c1cc2ccc(N(CC)CC)cc2oc1=O)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/acs.jmedchem.5b01495 | |||
| 10480064 | 221262 | 0 | None | None | None | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 475 | 9 | 2 | 6 | 4.5 | CCCCC(=O)N(Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1)[C@H](C(=O)O)C(C)C | 10.1021/jm00014a024 | |||
| CHEMBL328738 | 221262 | 0 | None | None | None | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 475 | 9 | 2 | 6 | 4.5 | CCCCC(=O)N(Cc1ccc2c(c1)Oc1ccccc1C=C2c1nnn[nH]1)[C@H](C(=O)O)C(C)C | 10.1021/jm00014a024 | |||
| 168270075 | 373150 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 541 | 8 | 1 | 9 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2nc(CC(C)C)sc2S(=O)(=O)NC(=O)OC)cc1 | 10.1016/j.bmc.2022.116790 | |||
| CHEMBL5172242 | 373150 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 541 | 8 | 1 | 9 | 5.0 | CCc1nc2c(C)cc(C)nc2n1Cc1ccc(-c2nc(CC(C)C)sc2S(=O)(=O)NC(=O)OC)cc1 | 10.1016/j.bmc.2022.116790 | |||
| 44567884 | 366376 | 0 | None | None | None | Pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 524 | 11 | 1 | 6 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(Oc2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| CHEMBL479367 | 366376 | 0 | None | None | None | Pig | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 524 | 11 | 1 | 6 | 5.8 | CCCCOC(=O)NS(=O)(=O)c1ccc(Oc2ccccc2)cc1-c1ccc(C(=O)N(CC)CC)cc1 | 10.1016/j.bmc.2008.05.066 | |||
| 145946191 | 332303 | 0 | None | -1096 | 2 | Human | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | 1165 | 26 | 5 | 14 | 4.5 | CCN(CC)c1ccc(C(=C2C=CC(=[N+](CC)CC)C=C2)c2ccc(S(=O)(=O)NCCCC[C@H](NC(=O)Cc3csc(=N)n3C)C(=O)N[C@@H](Cc3cn(Cc4ccccc4)c[n+]3C)C(=O)NC3CCN(C)CC3)cc2S(=O)(=O)[O-])cc1 | 10.1021/jm401789v | |||
| CHEMBL4300168 | 332303 | 0 | None | -1096 | 2 | Human | 4.0 | pKi | = | 4.0 | Binding | ChEMBL | 1165 | 26 | 5 | 14 | 4.5 | CCN(CC)c1ccc(C(=C2C=CC(=[N+](CC)CC)C=C2)c2ccc(S(=O)(=O)NCCCC[C@H](NC(=O)Cc3csc(=N)n3C)C(=O)N[C@@H](Cc3cn(Cc4ccccc4)c[n+]3C)C(=O)NC3CCN(C)CC3)cc2S(=O)(=O)[O-])cc1 | 10.1021/jm401789v | |||
| 2171 | 193979 | 62 | None | None | None | Bovine | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 334 | 3 | 2 | 4 | 3.1 | COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3[nH]2)cc1 | None | |||
| 4823 | 193979 | 62 | None | None | None | Bovine | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 334 | 3 | 2 | 4 | 3.1 | COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3[nH]2)cc1 | None | |||
| CHEMBL24646 | 193979 | 62 | None | None | None | Bovine | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 334 | 3 | 2 | 4 | 3.1 | COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3[nH]2)cc1 | None | |||
| DB11450 | 193979 | 62 | None | None | None | Bovine | 8.3 | pIC50 | = | 8.3 | Binding | Drug Central | 334 | 3 | 2 | 4 | 3.1 | COc1ccc(-c2nc3cc(C4=NNC(=O)CC4C)ccc3[nH]2)cc1 | None | |||
| 1610 | 4782 | 0 | None | None | None | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3961 | 4782 | 0 | None | None | None | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 590 | 4782 | 0 | None | None | None | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| CHEMBL191 | 4782 | 0 | None | None | None | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| DB00678 | 4782 | 0 | None | None | None | Bovine | 8.2 | pIC50 | = | 8.2 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 1610 | 4782 | 0 | None | None | None | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3961 | 4782 | 0 | None | None | None | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 590 | 4782 | 0 | None | None | None | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| CHEMBL191 | 4782 | 0 | None | None | None | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| DB00678 | 4782 | 0 | None | None | None | Guinea pig | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 24755620 | 8610 | 72 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 2806 | 8610 | 72 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 3937 | 8610 | 72 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 5284633 | 8610 | 72 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 60846 | 8610 | 72 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| CHEMBL1069 | 8610 | 72 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| CHEMBL115622 | 8610 | 72 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| CHEMBL5315276 | 8610 | 72 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| DB00177 | 8610 | 72 | None | None | None | Rat | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 1037 | 3247 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 5281037 | 3247 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 588 | 3247 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| CHEMBL813 | 3247 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| DB00876 | 3247 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | Drug Central | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | None | |||
| 2540 | 18749 | 72 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | |||
| 475 | 18749 | 72 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | |||
| CHEMBL1014 | 18749 | 72 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | |||
| DB00796 | 18749 | 72 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | |||
| 2583 | 8231 | 75 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 592 | 8231 | 75 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 65999 | 8231 | 75 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| CHEMBL1017 | 8231 | 75 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| DB00966 | 8231 | 75 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 172198 | 866 | 40 | None | None | None | Rat | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | |||
| 2504 | 866 | 40 | None | None | None | Rat | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | |||
| 5272 | 866 | 40 | None | None | None | Rat | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | |||
| CHEMBL408403 | 866 | 40 | None | None | None | Rat | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | |||
| DB11842 | 866 | 40 | None | None | None | Rat | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | |||
| P01015 | 866 | 40 | None | None | None | Rat | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | |||
| P01019 | 866 | 40 | None | None | None | Rat | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | |||
| P11859 | 866 | 40 | None | None | None | Rat | 8.0 | pIC50 | = | 8.0 | Binding | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | |||
| 172198 | 866 | 40 | None | -8 | 3 | Bovine | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | |||
| 2504 | 866 | 40 | None | -8 | 3 | Bovine | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | |||
| 5272 | 866 | 40 | None | -8 | 3 | Bovine | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | |||
| CHEMBL408403 | 866 | 40 | None | -8 | 3 | Bovine | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | |||
| DB11842 | 866 | 40 | None | -8 | 3 | Bovine | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | |||
| P01015 | 866 | 40 | None | -8 | 3 | Bovine | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | |||
| P01019 | 866 | 40 | None | -8 | 3 | Bovine | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | |||
| P11859 | 866 | 40 | None | -8 | 3 | Bovine | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 1046 | 29 | 13 | 13 | -1.3 | CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C | None | |||
| 1610 | 4782 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3961 | 4782 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 590 | 4782 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| CHEMBL191 | 4782 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| DB00678 | 4782 | 0 | None | None | None | Rabbit | 8.1 | pKd | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 2541 | 7891 | 68 | None | 109 | 2 | Human | 10.3 | pKd | = | 10.3 | Binding | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10079018 | |||
| 6907 | 7891 | 68 | None | 109 | 2 | Human | 10.3 | pKd | = | 10.3 | Binding | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10079018 | |||
| CHEMBL1016 | 7891 | 68 | None | 109 | 2 | Human | 10.3 | pKd | = | 10.3 | Binding | Guide to Pharmacology | 440 | 7 | 2 | 7 | 4.0 | CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O | 10079018 | |||
| 6916 | 7082 | 0 | None | None | None | Human | 6.5 | pKd | = | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 11901215 | |||||
| 6914 | 7084 | 0 | None | None | None | Human | 6.5 | pKd | = | 6.5 | Binding | Guide to Pharmacology | None | None | None | None | 12949261 | |||||
| 6903 | 7076 | 0 | None | None | None | Rat | 7.1 | pKd | = | 7.1 | Binding | Guide to Pharmacology | None | None | None | None | 10066768 | |||||
| 6903 | 7076 | 0 | None | None | None | Rat | 7.1 | pKd | = | 7.1 | Binding | Guide to Pharmacology | None | None | None | None | 11901215 | |||||
| 3082475 | 8432 | 22 | None | None | None | Human | 7.7 | pKd | = | 7.7 | Binding | Guide to Pharmacology | 926 | 26 | 12 | 12 | -2.1 | CNCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(=O)O)C)Cc1[nH]cnc1)[C@H](CC)C)Cc1ccc(cc1)O)C(C)C)CCCN=C(N)N | 20801892 | |||
| 6902 | 8432 | 22 | None | None | None | Human | 7.7 | pKd | = | 7.7 | Binding | Guide to Pharmacology | 926 | 26 | 12 | 12 | -2.1 | CNCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(=O)O)C)Cc1[nH]cnc1)[C@H](CC)C)Cc1ccc(cc1)O)C(C)C)CCCN=C(N)N | 20801892 | |||
| CHEMBL4297447 | 8432 | 22 | None | None | None | Human | 7.7 | pKd | = | 7.7 | Binding | Guide to Pharmacology | 926 | 26 | 12 | 12 | -2.1 | CNCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(=O)O)C)Cc1[nH]cnc1)[C@H](CC)C)Cc1ccc(cc1)O)C(C)C)CCCN=C(N)N | 20801892 | |||
| DB12199 | 8432 | 22 | None | None | None | Human | 7.7 | pKd | = | 7.7 | Binding | Guide to Pharmacology | 926 | 26 | 12 | 12 | -2.1 | CNCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(=O)O)C)Cc1[nH]cnc1)[C@H](CC)C)Cc1ccc(cc1)O)C(C)C)CCCN=C(N)N | 20801892 | |||
| 1610 | 7967 | 67 | None | -4 | 3 | Rat | 8.2 | pKd | = | 8.2 | Binding | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8282008 | |||
| 3941 | 7967 | 67 | None | -4 | 3 | Rat | 8.2 | pKd | = | 8.2 | Binding | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8282008 | |||
| 3961 | 7967 | 67 | None | -4 | 3 | Rat | 8.2 | pKd | = | 8.2 | Binding | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8282008 | |||
| CHEMBL191 | 7967 | 67 | None | -4 | 3 | Rat | 8.2 | pKd | = | 8.2 | Binding | Guide to Pharmacology | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | 8282008 | |||
| 1481 | 7955 | 73 | None | None | None | Human | 8.7 | pKd | = | 8.7 | Binding | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 11967808 | |||
| 3749 | 7955 | 73 | None | None | None | Human | 8.7 | pKd | = | 8.7 | Binding | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 11967808 | |||
| 6908 | 7955 | 73 | None | None | None | Human | 8.7 | pKd | = | 8.7 | Binding | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 11967808 | |||
| CHEMBL1513 | 7955 | 73 | None | None | None | Human | 8.7 | pKd | = | 8.7 | Binding | Guide to Pharmacology | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | 11967808 | |||
| 3942 | 7659 | 0 | None | None | None | Rat | 8.8 | pKd | = | 8.8 | Binding | Guide to Pharmacology | 665 | 10 | 3 | 7 | 5.7 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)C(=O)NCCc1ccc(c(c1)[125I])O)Cl | 1445340 | |||
| 73755063 | 7659 | 0 | None | None | None | Rat | 8.8 | pKd | = | 8.8 | Binding | Guide to Pharmacology | 665 | 10 | 3 | 7 | 5.7 | CCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)C(=O)NCCc1ccc(c(c1)[125I])O)Cl | 1445340 | |||
| 6915 | 7074 | 0 | None | None | None | Human | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | None | None | None | None | 11901215 | |||||
| 1037 | 7928 | 51 | None | None | None | Rat | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 8463997 | |||
| 3940 | 7928 | 51 | None | None | None | Rat | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 8463997 | |||
| 5281037 | 7928 | 51 | None | None | None | Rat | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 8463997 | |||
| CHEMBL813 | 7928 | 51 | None | None | None | Rat | 9.1 | pKd | = | 9.1 | Binding | Guide to Pharmacology | 424 | 10 | 2 | 5 | 4.7 | CCCCc1ncc(n1Cc1ccc(cc1)C(=O)O)/C=C(/C(=O)O)\Cc1cccs1 | 8463997 | |||
| 183134 | 7963 | 16 | None | None | None | Rat | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 1480133 | |||
| 3939 | 7963 | 16 | None | None | None | Rat | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 1480133 | |||
| CHEMBL7550 | 7963 | 16 | None | None | None | Rat | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | 409 | 5 | 1 | 6 | 4.5 | CCc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1[nH]nnn1)nc(cc2C)C | 1480133 | |||
| 132387 | 7872 | 20 | None | -9 | 2 | Rat | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | 414 | 8 | 2 | 6 | 4.0 | CCCN(c1ncccc1C(=O)O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8206129 | |||
| 3938 | 7872 | 20 | None | -9 | 2 | Rat | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | 414 | 8 | 2 | 6 | 4.0 | CCCN(c1ncccc1C(=O)O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8206129 | |||
| CHEMBL416477 | 7872 | 20 | None | -9 | 2 | Rat | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | 414 | 8 | 2 | 6 | 4.0 | CCCN(c1ncccc1C(=O)O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | 8206129 | |||
| 6904 | 7078 | 0 | None | None | None | Rat | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | None | None | None | None | 10066768 | |||||
| 6904 | 7078 | 0 | None | None | None | Rat | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | None | None | None | None | 11901215 | |||||
| 6905 | 7086 | 0 | None | None | None | Human | 9.4 | pKd | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 11901215 | |||||
| 6906 | 7766 | 0 | None | 14 | 2 | Rat | 9.4 | pKd | = | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 7759541 | |||||
| 6897 | 7765 | 0 | None | None | None | Rat | 9.5 | pKd | = | 9.5 | Binding | Guide to Pharmacology | None | None | None | None | 7759541 | |||||
| 24755620 | 8610 | 72 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 2806 | 8610 | 72 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 3937 | 8610 | 72 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 5284633 | 8610 | 72 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 60846 | 8610 | 72 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| CHEMBL1069 | 8610 | 72 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| CHEMBL115622 | 8610 | 72 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| CHEMBL5315276 | 8610 | 72 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| DB00177 | 8610 | 72 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 435 | 10 | 2 | 5 | 4.2 | CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 | None | |||
| 1610 | 4782 | 0 | None | None | None | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 3961 | 4782 | 0 | None | None | None | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 590 | 4782 | 0 | None | None | None | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| CHEMBL191 | 4782 | 0 | None | None | None | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| DB00678 | 4782 | 0 | None | None | None | Rat | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 422 | 8 | 2 | 6 | 4.3 | CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl | None | |||
| 1481 | 4225 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| 3749 | 4225 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| 589 | 4225 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| CHEMBL1513 | 4225 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| DB01029 | 4225 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 428 | 7 | 1 | 5 | 4.8 | CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 | None | |||
| 2540 | 18749 | 72 | None | -1 | 4 | Rabbit | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | |||
| 475 | 18749 | 72 | None | -1 | 4 | Rabbit | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | |||
| CHEMBL1014 | 18749 | 72 | None | -1 | 4 | Rabbit | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | |||
| DB00796 | 18749 | 72 | None | -1 | 4 | Rabbit | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 610 | 10 | 1 | 11 | 6.3 | CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 | None | |||
| 1056 | 6857 | 72 | None | None | None | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | None | |||
| 2405 | 6857 | 72 | None | None | None | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | None | |||
| 77999 | 6857 | 72 | None | None | None | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | None | |||
| CHEMBL121 | 6857 | 72 | None | None | None | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | None | |||
| DB00412 | 6857 | 72 | None | None | None | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 357 | 7 | 1 | 6 | 2.5 | O=C1NC(=O)C(S1)Cc1ccc(cc1)OCCN(c1ccccn1)C | None | |||
| 2583 | 8231 | 75 | None | None | None | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 592 | 8231 | 75 | None | None | None | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 65999 | 8231 | 75 | None | None | None | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| CHEMBL1017 | 8231 | 75 | None | None | None | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| DB00966 | 8231 | 75 | None | None | None | Rat | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 514 | 7 | 1 | 5 | 7.3 | CCCc1nc2c(n1Cc1ccc(cc1)c1ccccc1C(=O)O)cc(cc2C)c1nc2c(n1C)cccc2 | None | |||
| 3542 | 484387 | 24 | None | 1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | None | |||
| CHEMBL938 | 484387 | 24 | None | 1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 911 | 25 | 13 | 12 | -2.3 | CNCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C)C(C)C | None | |||
| 11944 | 8430 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 903 | 24 | 12 | 12 | -2.3 | CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CC3=CN=CN3)C(=O)N4CCC[C@H]4C(=O)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC | 30639099 | |||
| 145925550 | 8430 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 903 | 24 | 12 | 12 | -2.3 | CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CC3=CN=CN3)C(=O)N4CCC[C@H]4C(=O)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC | 30639099 | |||
| CHEMBL4577270 | 8430 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | Guide to Pharmacology | 903 | 24 | 12 | 12 | -2.3 | CC(C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CC3=CN=CN3)C(=O)N4CCC[C@H]4C(=O)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC | 30639099 | |||
| 11943 | 8428 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | 30639099 | |||
| 145925549 | 8428 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | 30639099 | |||
| 162679549 | 8428 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | 30639099 | |||
| CHEMBL4438122 | 8428 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 941 | 28 | 13 | 13 | -3.0 | CC(C)C(C(=O)NC(Cc1ccc(cc1)O)C(=O)NC(CCCCN)C(=O)NC(Cc1cnc[nH]1)C(=O)N1CCCC1C(=O)NC(C)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)CNC | 30639099 | |||
| 11930 | 2105 | 0 | None | -537 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | |||
| 15780052 | 2105 | 0 | None | -537 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | |||
| CHEMBL289472 | 2105 | 0 | None | -537 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | Guide to Pharmacology | 623 | 9 | 1 | 8 | 6.8 | CCc1nc2c(cc(cc2)N(Cc2ccccc2)C(=O)c2cccs2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | |||
| 11931 | 2196 | 0 | None | -10 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 621 | 10 | 1 | 8 | 6.7 | CCCc1nc2c(cc(cc2)N(Cc2ccco2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | |||
| 126456406 | 2196 | 0 | None | -10 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 621 | 10 | 1 | 8 | 6.7 | CCCc1nc2c(cc(cc2)N(Cc2ccco2)C(=O)c2ccccc2)c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1 | 28379944 | |||
| 10257882 | 7409 | 51 | None | 7 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 37022667 | |||
| 8448 | 7409 | 51 | None | 7 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 37022667 | |||
| CHEMBL539423 | 7409 | 51 | None | 7 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 37022667 | |||
| DB12548 | 7409 | 51 | None | 7 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 37022667 | |||
| 6894 | 864 | 0 | None | 1 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 1002 | 27 | 12 | 12 | -0.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 21464395 | |||
| 91691124 | 864 | 0 | None | 1 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 1002 | 27 | 12 | 12 | -0.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 21464395 | |||
| P01019 | 864 | 0 | None | 1 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 1002 | 27 | 12 | 12 | -0.8 | CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 21464395 | |||
| 136218976 | 307 | 0 | None | None | None | Rat | 9.0 | pKi | = | 9.0 | Binding | Guide to Pharmacology | 423 | 9 | 2 | 5 | 3.7 | CCC[C@H](N(C(=O)CC)Cc1ccc(cc1)c1ccccc1c1noc(=O)[nH]1)C(=O)O | 22410249 | |||
| 6913 | 307 | 0 | None | None | None | Rat | 9.0 | pKi | = | 9.0 | Binding | Guide to Pharmacology | 423 | 9 | 2 | 5 | 3.7 | CCC[C@H](N(C(=O)CC)Cc1ccc(cc1)c1ccccc1c1noc(=O)[nH]1)C(=O)O | 22410249 | |||
| 60921 | 7055 | 0 | None | None | None | Rat | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 610 | 8 | 2 | 6 | 5.9 | CCc1nc(c(n1Cc1ccc2c(c1)c(Br)c(o2)c1ccccc1NS(=O)(=O)C(F)(F)F)C(=O)N)C1CC1 | 7853190 | |||
| 6899 | 7055 | 0 | None | None | None | Rat | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 610 | 8 | 2 | 6 | 5.9 | CCc1nc(c(n1Cc1ccc2c(c1)c(Br)c(o2)c1ccccc1NS(=O)(=O)C(F)(F)F)C(=O)N)C1CC1 | 7853190 | |||
| CHEMBL305544 | 7055 | 0 | None | None | None | Rat | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 610 | 8 | 2 | 6 | 5.9 | CCc1nc(c(n1Cc1ccc2c(c1)c(Br)c(o2)c1ccccc1NS(=O)(=O)C(F)(F)F)C(=O)N)C1CC1 | 7853190 | |||
| DB01347 | 7055 | 0 | None | None | None | Rat | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 610 | 8 | 2 | 6 | 5.9 | CCc1nc(c(n1Cc1ccc2c(c1)c(Br)c(o2)c1ccccc1NS(=O)(=O)C(F)(F)F)C(=O)N)C1CC1 | 7853190 | |||
| 10257882 | 7409 | 51 | None | 7 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 16220969 | |||
| 8448 | 7409 | 51 | None | 7 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 16220969 | |||
| CHEMBL539423 | 7409 | 51 | None | 7 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 16220969 | |||
| DB12548 | 7409 | 51 | None | 7 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 592 | 12 | 1 | 7 | 6.5 | CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 | 16220969 | |||