PF-514273
| SMILES | Clc1c(cccc1)n1nc2C(=O)N(CCOc2c1c1ccc(cc1)Cl)CC(C)(F)F |
| InChIKey | FJMQJSUOOGOWBD-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 4 |
| Hydrogen bond donors | 0 |
| Rotatable bonds | 4 |
| Molecular weight (Da) | 451.1 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Surrogate |
| Approved drug | No |
Database connections
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| CB1 | CNR1 | Human | Cannabinoid | A | pKi | 9.09 | 9.09 | 9.09 | Guide to Pharmacology |
| CB1 | CNR1 | Human | Cannabinoid | A | pKi | 9.0 | 9.04 | 9.09 | ChEMBL |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| GPR119 | GP119 | Human | GPR18, GPR55 and GPR119 | A | pEC50 | 6.26 | 6.26 | 6.26 | ChEMBL |
| AT1 | AGTR1 | Human | Angiotensin | A | pEC50 | 5.9 | 5.9 | 5.9 | ChEMBL |
| FFA4 | FFAR4 | Human | Free fatty acid | A | pEC50 | 5.92 | 5.92 | 5.92 | ChEMBL |
| α2A | ADA2A | Human | Adrenoceptors | A | pEC50 | 5.97 | 5.97 | 5.97 | ChEMBL |
| β2 | ADRB2 | Human | Adrenoceptors | A | pEC50 | 5.84 | 5.84 | 5.84 | ChEMBL |
| GLP-1 | GLP1R | Human | Glucagon | B1 | pEC50 | 5.64 | 5.64 | 5.64 | ChEMBL |
| CX3CR1 | CX3C1 | Human | Chemokine | A | pEC50 | 4.75 | 4.75 | 4.75 | ChEMBL |
| ADGRF1 | AGRF1 | Human | ADGRF | B2 | pEC50 | 5.69 | 5.69 | 5.69 | ChEMBL |