[3H]losartan


SMILES CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl
InChIKey PSIFNNKUMBGKDQ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 8
Molecular weight (Da) 422.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
AT1 AGTRA Rat Angiotensin A pKd 8.21 8.21 8.21 Guide to Pharmacology
AT1 AGTRA Rat Angiotensin A pKd 7.4 7.7 8.0 ChEMBL
AT1 AGTRA Rat Angiotensin A pKi 7.84 7.85 7.86 ChEMBL
AT1 AGTR1 Rabbit Angiotensin A pKd 6.7 7.94 8.8 ChEMBL
AT2 AGTR2 Human Angiotensin A pKi 8.26 8.26 8.26 ChEMBL
AT1 AGTR1 Human Angiotensin A pKd 8.48 8.48 8.48 ChEMBL
AT1 AGTR1 Human Angiotensin A pKi 7.77 8.04 8.3 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.46 5.46 5.46 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
AT1 AGTR1 Bovine Angiotensin A pIC50 6.37 6.7 7.02 ChEMBL
AT1 AGTR1 Bovine Angiotensin A pEC50 6.46 6.46 6.46 ChEMBL
AT1 AGTRA Rat Angiotensin A pIC50 7.72 7.95 8.17 ChEMBL
AT2 AGTR2 Rat Angiotensin A pIC50 4.13 4.52 5.13 ChEMBL
AT1 AGTR1 Rabbit Angiotensin A pIC50 7.21 7.49 8.52 ChEMBL
AT2 AGTR2 Human Angiotensin A pIC50 5.0 7.06 7.96 ChEMBL
AT1 AGTR1 Human Angiotensin A pIC50 6.46 7.9 9.48 ChEMBL
TP TA2R Human Prostanoid A pIC50 4.7 4.7 4.7 ChEMBL
AT1 AGTR1 Guinea pig Angiotensin A pIC50 7.75 7.75 7.75 ChEMBL