losartan


SMILES CCCCc1nc(c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CO)Cl
InChIKey PSIFNNKUMBGKDQ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 8
Molecular weight (Da) 422.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 9EAI 8TH4

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
AT1 AGTRA Rat Angiotensin A pKi 8.11 8.11 8.11 Drug Central
AT1 AGTR1 Rabbit Angiotensin A pKd 8.06 8.06 8.06 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
AT1 AGTR1 Human Angiotensin A pIC50 7.4 8.05 8.7 Guide to Pharmacology
AT1 AGTR1 Human Angiotensin A pIC50 8.02 8.02 8.02 Drug Central
AT2 AGTR2 Human Angiotensin A pIC50 8.3 8.3 8.3 Drug Central
AT2 AGTR2 Rat Angiotensin A pIC50 8.29 8.29 8.29 Drug Central
AT1 AGTR1 Guinea pig Angiotensin A pIC50 8.11 8.11 8.11 Drug Central
AT1 AGTR1 Bovine Angiotensin A pIC50 8.15 8.15 8.15 Drug Central