CB1 receptor - Beta-arrestin-1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

ARRESTIN (FAMILY)

Beta

ARRESTIN

Beta-arrestin-1

ARRESTIN SPECIES

Human

ARRESTIN CHAIN

C

ARRESTIN COVERAGE

86

PDB CODE

8WU1

RESOLUTION

3.2 Å

REFERENCE

10.1016/J.CELL.2023.11.017

PUBLICATION DATE

March 20, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

35 interactions (Click to see)

LIGANDS

MDMB-Fubinaca - Agonist pubchem gtoplig

PHYSIOLOGICAL LIGANDS

anandamide



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 R 307 5x71 s15s16 C 242 C.s15s16.01
Polar ICL2 R 226 34x55 s17s18 R 285 C.s17s18.11
Hydrophobic TM7 R 400 7x56 s5s6 L 71 N.s5s6.08
Van-der-waals TM7 R 400 7x56 s5s6 L 71 N.s5s6.08
Polar ICL2 L 222 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 222 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 R 226 34x55 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 222 34x51 S8 L 129 N.S8.03
Hydrophobic TM3 I 218 3x54 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 L 222 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 222 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 221 34x50 s15s16 L 243 C.s15s16.02
Hydrophobic TM5 R 307 5x71 s17s18 E 313 C.s17s18.39
Van-der-waals TM5 R 307 5x71 s17s18 E 313 C.s17s18.39
Hydrophobic ICL2 L 222 34x51 S15 I 241 C.S15.14
Hydrophobic ICL2 Y 224 34x53 s5s6 L 68 N.s5s6.05
Van-der-waals ICL2 Y 224 34x53 s5s6 L 68 N.s5s6.05
Aromatic TM5 H 304 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 H 304 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 H 304 5x68 s15s16 F 244 C.s15s16.03
Polar TM6 A 342 6x34 s5s6 G 72 N.s5s6.09
Hydrophobic H8 S 401 8x47 s5s6 L 71 N.s5s6.08
Van-der-waals TM5 H 304 5x68 s15s16 L 243 C.s15s16.02
Aromatic TM3 R 220 3x56 S16 Y 249 C.S16.03
Hydrophobic TM3 R 220 3x56 S16 Y 249 C.S16.03
Van-der-waals TM3 R 220 3x56 S16 Y 249 C.S16.03
Polar TM3 R 214 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 214 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 K 225 34x54 s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 K 225 34x54 s17s18 R 285 C.s17s18.11
Polar TM3 H 219 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 H 219 3x55 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 L 341 6x33 s5s6 G 72 N.s5s6.09
Hydrophobic TM5 A 301 5x65 s5s6 L 73 N.s5s6.10
Polar TM5 R 307 5x71 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 R 307 5x71 s15s16 F 244 C.s15s16.03