CB1 receptor - Beta-arrestin-1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

ARRESTIN (FAMILY)

Beta

ARRESTIN

Beta-arrestin-1

ARRESTIN SPECIES

Human

ARRESTIN CHAIN

A

ARRESTIN COVERAGE

84

PDB CODE

8WRZ

RESOLUTION

3.6 Å

REFERENCE

10.1093/PROCEL/PWAD055

PUBLICATION DATE

Feb. 28, 2024

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

AM841 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

anandamide



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 222 34x51 S16 C 251 C.S16.05
Hydrophobic H8 S 401 8x47 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 K 225 34x54 s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 K 225 34x54 s17s18 R 285 C.s17s18.11
Hydrophobic TM6 E 340 6x32 S6 F 75 N.S6.01
Van-der-waals TM6 E 340 6x32 S6 F 75 N.S6.01
Hydrophobic ICL1 R 150 - s5s6 L 68 N.s5s6.05
Van-der-waals ICL1 R 150 - s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 L 222 34x51 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 L 222 34x51 s5s6 R 65 N.s5s6.02
Polar TM5 H 304 5x68 s15s16 L 243 C.s15s16.02
Hydrophobic TM5 H 304 5x68 s15s16 L 243 C.s15s16.02
Van-der-waals TM5 H 304 5x68 s15s16 L 243 C.s15s16.02
Hydrophobic TM5 H 304 5x68 s15s16 T 246 C.s15s16.05
Van-der-waals TM5 H 304 5x68 s15s16 T 246 C.s15s16.05
Polar TM5 H 304 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 H 304 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 H 304 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic H8 K 402 8x48 s5s6 L 71 N.s5s6.08
Van-der-waals H8 K 402 8x48 s5s6 L 71 N.s5s6.08
Hydrophobic H8 D 403 8x49 s5s6 L 71 N.s5s6.08
Van-der-waals H8 D 403 8x49 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 P 221 34x50 S16 A 247 C.S16.01
Ionic ICL2 K 225 34x54 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 K 225 34x54 s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 K 225 34x54 s8s9 E 134 N.s8s9.05
Hydrophobic TM5 R 311 5x75 s17s18 R 312 C.s17s18.38
Van-der-waals TM5 R 311 5x75 s17s18 R 312 C.s17s18.38
Polar TM3 I 218 3x54 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 I 218 3x54 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 I 218 3x54 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 L 222 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 222 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 222 34x51 s17s18 G 286 C.s17s18.12
Van-der-waals ICL2 L 222 34x51 s17s18 G 286 C.s17s18.12
Polar TM7 R 400 7x56 s5s6 G 72 N.s5s6.09
Van-der-waals TM7 R 400 7x56 s5s6 G 72 N.s5s6.09
Van-der-waals ICL2 P 221 34x50 s5s6 R 65 N.s5s6.02
Ionic TM5 R 311 5x75 s17s18 E 313 C.s17s18.39
Hydrophobic TM5 R 311 5x75 s17s18 E 313 C.s17s18.39
Van-der-waals TM5 R 311 5x75 s17s18 E 313 C.s17s18.39