glucagon receptor - Beta-arrestin-1

GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

ARRESTIN (FAMILY)

Beta

ARRESTIN

Beta-arrestin-1

ARRESTIN SPECIES

Human

ARRESTIN CHAIN

A

ARRESTIN COVERAGE

85

PDB CODE

8JRV

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41586-023-06420-X

PUBLICATION DATE

Aug. 16, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

16 interactions (Click to see)

LIGANDS

glucagon - Agonist pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem pubchem pubchem pubchem

PHYSIOLOGICAL LIGANDS

glucagon



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Aromatic H8 W 425 8x68 s17s18 R 285 C.s17s18.11
Hydrophobic H8 W 425 8x68 s17s18 R 285 C.s17s18.11
Van-der-waals H8 W 425 8x68 s17s18 R 285 C.s17s18.11
Hydrophobic H8 L 424 8x67 S5 F 61 N.S5.10
Hydrophobic H8 L 424 8x67 s15s16 L 243 C.s15s16.02
Hydrophobic H8 W 425 8x68 s17s18 G 286 C.s17s18.12
Van-der-waals H8 W 425 8x68 s17s18 G 286 C.s17s18.12
Polar H8 R 417 8x60 S16 Y 249 C.S16.03
Aromatic H8 R 417 8x60 S16 Y 249 C.S16.03
Hydrophobic H8 R 417 8x60 S16 Y 249 C.S16.03
Hydrophobic H8 L 420 8x63 s15s16 V 242 C.s15s16.01
Polar H8 G 421 8x64 S16 Y 249 C.S16.03
Van-der-waals H8 G 421 8x64 S16 Y 249 C.S16.03
Hydrophobic H8 L 420 8x63 S15 I 241 C.S15.14
Van-der-waals H8 L 420 8x63 S15 I 241 C.S15.14
Hydrophobic H8 L 420 8x63 s15s16 N 245 C.s15s16.04
Van-der-waals H8 L 420 8x63 s15s16 N 245 C.s15s16.04
Hydrophobic H8 L 424 8x67 S9 I 140 N.S9.01
Van-der-waals H8 L 424 8x67 S9 I 140 N.S9.01
Hydrophobic H8 H 416 8x59 S16 A 247 C.S16.01
Hydrophobic H8 L 424 8x67 S8 L 129 N.S8.03
Hydrophobic H8 V 423 8x66 s15s16 L 243 C.s15s16.02
Hydrophobic H8 L 420 8x63 S16 Y 249 C.S16.03
Van-der-waals H8 L 420 8x63 S16 Y 249 C.S16.03
Hydrophobic H8 L 424 8x67 S15 I 241 C.S15.14
Polar H8 H 416 8x59 s15s16 N 245 C.s15s16.04
Hydrophobic H8 H 416 8x59 s15s16 N 245 C.s15s16.04
Van-der-waals H8 H 416 8x59 s15s16 N 245 C.s15s16.04
Hydrophobic H8 R 417 8x60 S16 A 247 C.S16.01
Van-der-waals H8 R 417 8x60 S16 A 247 C.S16.01
Hydrophobic TM4 S 265 4x44 s11s12 M 192 C.s11s12.03
Aromatic H8 W 425 8x68 S16 Y 249 C.S16.03
Hydrophobic H8 W 425 8x68 S16 Y 249 C.S16.03
Van-der-waals H8 W 425 8x68 S16 Y 249 C.S16.03
Hydrophobic H8 L 420 8x63 S16 A 247 C.S16.01
Polar H8 R 417 8x60 S16 Q 248 C.S16.02
Van-der-waals H8 R 417 8x60 S16 Q 248 C.S16.02