GPCR CLASS (FAMILY)

Class B1 (Secretin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

ARRESTIN (FAMILY)

Beta

ARRESTIN

ARRESTIN SPECIES

Bovine

ARRESTIN CHAIN

A

ARRESTIN COVERAGE

83

PDB CODE

RESOLUTION

3.5 Å

REFERENCE

PUBLICATION DATE

Aug. 16, 2023

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

glucagon



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Arrestin
segment

AA

Number
Generic
number
Hydrophobic H8 W 425 8x68 S9 I 140 N.S9.01
Aromatic H8 W 425 8x68 s17s18 R 285 C.s17s18.11
Hydrophobic H8 W 425 8x68 s17s18 R 285 C.s17s18.11
Van-der-waals H8 W 425 8x68 s17s18 R 285 C.s17s18.11
Hydrophobic H8 L 424 8x67 s15s16 L 243 C.s15s16.02
Van-der-waals H8 L 424 8x67 s15s16 L 243 C.s15s16.02
Hydrophobic H8 V 423 8x66 S5 Y 63 N.S5.12
Hydrophobic H8 W 425 8x68 s17s18 G 286 C.s17s18.12
Aromatic H8 R 417 8x60 S16 Y 249 C.S16.03
Hydrophobic H8 R 417 8x60 S16 Y 249 C.S16.03
Hydrophobic H8 L 420 8x63 s15s16 V 242 C.s15s16.01
Polar H8 G 421 8x64 S16 Y 249 C.S16.03
Van-der-waals H8 G 421 8x64 S16 Y 249 C.S16.03
Hydrophobic H8 L 420 8x63 S15 I 241 C.S15.14
Van-der-waals H8 L 420 8x63 S15 I 241 C.S15.14
Hydrophobic H8 L 420 8x63 s15s16 N 245 C.s15s16.04
Van-der-waals H8 L 420 8x63 s15s16 N 245 C.s15s16.04
Polar H8 L 424 8x67 s5s6 G 64 N.s5s6.01
Hydrophobic H8 L 424 8x67 s5s6 G 64 N.s5s6.01
Hydrophobic H8 H 416 8x59 S16 A 247 C.S16.01
Hydrophobic H8 L 424 8x67 S8 L 129 N.S8.03
Hydrophobic H8 L 420 8x63 S16 Y 249 C.S16.03
Van-der-waals H8 L 420 8x63 S16 Y 249 C.S16.03
Hydrophobic H8 L 424 8x67 S15 I 241 C.S15.14
Polar H8 H 416 8x59 s15s16 N 245 C.s15s16.04
Hydrophobic H8 H 416 8x59 s15s16 N 245 C.s15s16.04
Van-der-waals H8 H 416 8x59 s15s16 N 245 C.s15s16.04
Hydrophobic H8 R 417 8x60 S16 A 247 C.S16.01
Hydrophobic H8 W 425 8x68 S8 L 129 N.S8.03
Hydrophobic H8 L 420 8x63 S16 A 247 C.S16.01
Polar H8 R 417 8x60 S16 Q 248 C.S16.02
Hydrophobic H8 R 417 8x60 S16 Q 248 C.S16.02
Van-der-waals H8 R 417 8x60 S16 Q 248 C.S16.02