5-HT2B receptor - Beta-arrestin-1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

ARRESTIN (FAMILY)

Beta

ARRESTIN

Beta-arrestin-1

ARRESTIN SPECIES

Human

ARRESTIN CHAIN

C

ARRESTIN COVERAGE

85

PDB CODE

7SRS

RESOLUTION

3.3 Å

REFERENCE

10.1016/J.NEURON.2022.08.006

PUBLICATION DATE

Sept. 21, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

25 interactions (Click to see)

LIGANDS

Lysergide - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

5-hydroxytryptamine



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 K 159 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 P 160 34x50 S6 F 75 N.S6.01
Hydrophobic ICL4 N 384 - s5s6 V 70 N.s5s6.07
Hydrophobic C-term I 459 - ns1 T 6 N.ns1.14
Van-der-waals C-term I 459 - ns1 T 6 N.ns1.14
Hydrophobic C-term L 460 - H1 L 104 N.H1.06
Hydrophobic ICL2 Q 162 34x52 S16 A 247 C.S16.01
Hydrophobic ICL2 N 164 34x54 s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 N 164 34x54 s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 Q 165 34x55 S16 Y 249 C.S16.03
Van-der-waals ICL2 Q 165 34x55 S16 Y 249 C.S16.03
Hydrophobic ICL2 I 161 34x51 s15s16 L 243 C.s15s16.02
Hydrophobic TM6 N 318 6x29 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 N 318 6x29 s5s6 G 72 N.s5s6.09
Hydrophobic C-term I 459 - ns1 R 7 N.ns1.15
Van-der-waals C-term I 459 - ns1 R 7 N.ns1.15
Hydrophobic C-term I 453 - S1 K 11 N.S1.04
Polar TM6 T 315 6x26 s5s6 T 74 N.s5s6.11
Hydrophobic C-term L 460 - S1 V 8 N.S1.01
Polar ICL2 P 160 34x50 S5 Y 63 N.S5.12
Hydrophobic TM5 V 247 5x68 s15s16 F 244 C.s15s16.03
Polar C-term L 460 - ns1 T 6 N.ns1.14
Polar TM2 T 89 2x39 s5s6 D 67 N.s5s6.04
Hydrophobic C-term L 460 - H1 K 107 N.H1.09
Van-der-waals C-term L 460 - H1 K 107 N.H1.09
Polar ICL2 N 164 34x54 S5 Y 63 N.S5.12
Van-der-waals ICL2 N 164 34x54 S5 Y 63 N.S5.12
Hydrophobic ICL2 I 161 34x51 S5 Y 63 N.S5.12
Polar ICL2 Q 162 34x52 S16 Y 249 C.S16.03
Hydrophobic ICL2 Q 162 34x52 S16 Y 249 C.S16.03
Van-der-waals ICL2 Q 162 34x52 S16 Y 249 C.S16.03
Hydrophobic TM6 A 322 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 I 161 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 I 161 34x51 S15 I 241 C.S15.14
Polar C-term I 453 - S1 A 12 N.S1.05
Polar C-term I 458 - S1 V 8 N.S1.01
Hydrophobic C-term I 458 - S1 V 8 N.S1.01
Van-der-waals C-term I 458 - S1 V 8 N.S1.01
Polar ICL3 S 251 - S6 R 76 N.S6.02
Van-der-waals ICL3 S 251 - S6 R 76 N.S6.02
Hydrophobic TM6 A 322 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 322 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic C-term L 460 - H1 R 103 N.H1.05
Polar ICL2 N 164 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM6 L 326 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic C-term I 458 - H1 K 107 N.H1.09
Hydrophobic ICL2 I 161 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 I 161 34x51 S16 Y 249 C.S16.03
Hydrophobic TM2 Y 87 2x37 s8s9 E 134 N.s8s9.05
Hydrophobic ICL3 S 251 - s15s16 F 244 C.s15s16.03
Van-der-waals ICL3 S 251 - s15s16 F 244 C.s15s16.03