V2 receptor - Beta-arrestin-1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

A

ARRESTIN (FAMILY)

Beta

ARRESTIN

Beta-arrestin-1

ARRESTIN SPECIES

Human

ARRESTIN CHAIN

C

ARRESTIN COVERAGE

84

PDB CODE

7R0C

RESOLUTION

4.7 Å

REFERENCE

10.1126/SCIADV.ABO7761

PUBLICATION DATE

Sept. 14, 2022

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

50 interactions (Click to see)

LIGANDS

vasopressin - Agonist pubchem gtoplig chembl_ligand drugbank drug_central

PHYSIOLOGICAL LIGANDS

vasopressin, oxytocin



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 A 265 6x29 s5s6 L 68 N.s5s6.05
Van-der-waals TM6 A 265 6x29 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 L 146 - S16 Y 249 C.S16.03
Van-der-waals ICL2 L 146 - S16 Y 249 C.S16.03
Hydrophobic TM6 T 269 6x33 s5s6 L 68 N.s5s6.05
Van-der-waals TM6 T 269 6x33 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 P 144 - S15 I 241 C.S15.14
Aromatic ICL2 R 143 - S16 Y 249 C.S16.03
Hydrophobic ICL2 R 143 - S16 Y 249 C.S16.03
Van-der-waals ICL2 R 143 - S16 Y 249 C.S16.03
Hydrophobic ICL2 M 145 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 M 145 - s5s6 R 65 N.s5s6.02
Hydrophobic C-term L 365 - H1 K 107 N.H1.09
Hydrophobic TM2 I 74 2x39 s5s6 E 66 N.s5s6.03
Van-der-waals TM2 I 74 2x39 s5s6 E 66 N.s5s6.03
Polar ICL2 P 144 - S16 Y 249 C.S16.03
Hydrophobic ICL2 P 144 - S16 Y 249 C.S16.03
Van-der-waals ICL2 P 144 - S16 Y 249 C.S16.03
Hydrophobic C-term C 358 - s1s2 S 13 N.s1s2.01
Van-der-waals C-term C 358 - s1s2 S 13 N.s1s2.01
Hydrophobic ICL2 A 147 - S16 C 251 C.S16.05
Van-der-waals ICL2 A 147 - S16 C 251 C.S16.05
Polar C-term L 365 - ns1 T 6 N.ns1.14
Hydrophobic C-term L 365 - ns1 T 6 N.ns1.14
Van-der-waals C-term L 365 - ns1 T 6 N.ns1.14
Polar TM3 I 141 3x54 S5 Y 63 N.S5.12
Polar C-term C 358 - s1s2 P 14 N.s1s2.02
Hydrophobic C-term C 358 - s1s2 P 14 N.s1s2.02
Van-der-waals C-term C 358 - s1s2 P 14 N.s1s2.02
Hydrophobic TM2 P 73 2x38 s17s18 R 285 C.s17s18.11
Van-der-waals TM2 P 73 2x38 s17s18 R 285 C.s17s18.11
Hydrophobic C-term L 365 - S1 V 8 N.S1.01
Polar C-term C 358 - S1 A 12 N.S1.05
Hydrophobic C-term C 358 - S1 A 12 N.S1.05
Van-der-waals C-term C 358 - S1 A 12 N.S1.05
Hydrophobic ICL1 H 70 - s8s9 E 134 N.s8s9.05
Van-der-waals ICL1 H 70 - s8s9 E 134 N.s8s9.05
Polar ICL3 A 234 - S6 K 77 N.S6.03
Hydrophobic ICL3 A 234 - S6 K 77 N.S6.03
Van-der-waals ICL3 A 234 - S6 K 77 N.S6.03
Ionic TM3 R 137 3x50 s5s6 D 69 N.s5s6.06
Polar TM3 R 137 3x50 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 R 137 3x50 s5s6 D 69 N.s5s6.06
Van-der-waals TM3 R 137 3x50 s5s6 D 69 N.s5s6.06
Polar ICL3 H 233 - S5 Y 63 N.S5.12
Hydrophobic ICL3 H 233 - S5 Y 63 N.S5.12
Hydrophobic C-term L 365 - H1 L 100 N.H1.02
Hydrophobic ICL2 M 145 - S16 Y 249 C.S16.03
Van-der-waals ICL2 M 145 - S16 Y 249 C.S16.03
Ionic C-term D 368 - H1 R 99 N.H1.01
Polar C-term D 368 - H1 R 99 N.H1.01
Van-der-waals C-term D 368 - H1 R 99 N.H1.01
Hydrophobic ICL2 A 147 - s17s18 K 284 C.s17s18.10
Hydrophobic TM6 K 268 6x32 s5s6 L 68 N.s5s6.05
Van-der-waals TM6 K 268 6x32 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 M 145 - S8 L 129 N.S8.03
Hydrophobic C-term A 361 - S1 F 9 N.S1.02
Van-der-waals C-term A 361 - S1 F 9 N.S1.02
Polar C-term A 361 - S1 K 10 N.S1.03
Hydrophobic C-term A 361 - S1 K 10 N.S1.03
Van-der-waals C-term A 361 - S1 K 10 N.S1.03
Hydrophobic C-term L 365 - H1 R 103 N.H1.05
Van-der-waals C-term L 365 - H1 R 103 N.H1.05
Hydrophobic ICL2 A 147 - s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 A 147 - s17s18 R 285 C.s17s18.11
Polar ICL2 C 142 - S5 Y 63 N.S5.12
Van-der-waals ICL2 C 142 - S5 Y 63 N.S5.12
Hydrophobic ICL2 M 145 - s5s6 G 64 N.s5s6.01
Van-der-waals ICL2 M 145 - s5s6 G 64 N.s5s6.01