NTS1 receptor - Beta-arrestin-1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

ARRESTIN (FAMILY)

Beta

ARRESTIN

Beta-arrestin-1

ARRESTIN SPECIES

Human

ARRESTIN CHAIN

B

ARRESTIN COVERAGE

83

PDB CODE

6UP7

RESOLUTION

4.2 Å

REFERENCE

10.1038/S41586-020-1953-1

PUBLICATION DATE

Feb. 26, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

32 interactions (Click to see)

LIGANDS

JMV431 - Agonist gtoplig chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

neurotensin, neuromedin N, large neurotensin, large neuromedin N



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 170 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 K 177 34x54 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 K 177 34x54 s15s16 N 245 C.s15s16.04
Polar ICL1 Q 98 - s5s6 R 65 N.s5s6.02
Hydrophobic ICL1 Q 98 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL1 Q 98 - s5s6 R 65 N.s5s6.02
Hydrophobic ICL3 F 286 - S6 F 75 N.S6.01
Van-der-waals ICL3 F 286 - S6 F 75 N.S6.01
Hydrophobic ICL3 I 290 - s5s6 L 73 N.s5s6.10
Van-der-waals ICL3 I 290 - s5s6 L 73 N.s5s6.10
Hydrophobic TM6 A 297 6x29 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 A 297 6x29 s5s6 L 71 N.s5s6.08
Hydrophobic ICL1 S 96 - S16 V 251 C.S16.05
Van-der-waals ICL1 S 96 - S16 V 251 C.S16.05
Hydrophobic ICL1 Q 98 - S16 A 247 C.S16.01
Van-der-waals ICL1 Q 98 - S16 A 247 C.S16.01
Hydrophobic ICL2 K 177 34x54 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 K 177 34x54 s15s16 T 246 C.s15s16.05
Polar TM6 L 298 6x30 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 G 301 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic ICL1 L 97 - s17s18 G 286 C.s17s18.12
Van-der-waals ICL1 L 97 - s17s18 G 286 C.s17s18.12
Polar ICL3 S 287 - S6 R 76 N.S6.02
Hydrophobic ICL3 S 287 - S6 R 76 N.S6.02
Van-der-waals ICL3 S 287 - S6 R 76 N.S6.02
Polar ICL3 M 288 - S6 R 76 N.S6.02
Van-der-waals ICL1 Q 95 - s17s18 R 285 C.s17s18.11
Polar TM1 S 93 1x62 s17s18 K 284 C.s17s18.10
Van-der-waals H8 N 370 8x49 s17s18 R 285 C.s17s18.11
Hydrophobic ICL3 F 286 - S6 K 77 N.S6.03
Van-der-waals ICL3 F 286 - S6 K 77 N.S6.03
Hydrophobic ICL1 L 97 - S16 V 251 C.S16.05
Hydrophobic ICL3 M 288 - S6 F 75 N.S6.01
Van-der-waals ICL3 M 288 - S6 F 75 N.S6.01
Hydrophobic H8 S 368 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic ICL3 M 288 - s5s6 T 74 N.s5s6.11
Polar ICL1 S 96 - s17s18 K 284 C.s17s18.10
Hydrophobic ICL3 I 290 - s5s6 G 72 N.s5s6.09
Polar ICL1 Q 98 - S5 Y 63 N.S5.12
Hydrophobic ICL3 F 286 - S6 R 76 N.S6.02
Van-der-waals ICL3 F 286 - S6 R 76 N.S6.02
Hydrophobic TM2 V 101 2x39 s5s6 D 67 N.s5s6.04