GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

ARRESTIN (FAMILY)

Beta

ARRESTIN

ARRESTIN SPECIES

Rat

ARRESTIN CHAIN

C

ARRESTIN COVERAGE

86

PDB CODE

RESOLUTION

4.0 Å

REFERENCE

PUBLICATION DATE

Feb. 26, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

LY2119620 - Agonist pubchem gtoplig chembl_ligand

PHYSIOLOGICAL LIGANDS

acetylcholine



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Arrestin
segment

AA

Number
Generic
number
Hydrophobic ICL2 L 129 34x51 S8 L 129 N.S8.03
Hydrophobic ICL2 V 133 34x55 s17s18 R 285 C.s17s18.11
Hydrophobic TM7 C 443 7x56 s5s6 L 71 N.s5s6.08
Polar ICL2 L 129 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 129 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 129 34x51 S16 Y 249 C.S16.03
Hydrophobic TM2 N 58 2x39 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 R 121 3x50 s5s6 V 70 N.s5s6.07
Polar ICL2 T 130 34x52 S16 Y 249 C.S16.03
Van-der-waals ICL2 T 130 34x52 S16 Y 249 C.S16.03