β1-adrenoceptor - Beta-arrestin-1

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Meleagris gallopavo

GPCR PREFERRED CHAIN

A

ARRESTIN (FAMILY)

Beta

ARRESTIN

Beta-arrestin-1

ARRESTIN SPECIES

Human

ARRESTIN CHAIN

B

ARRESTIN COVERAGE

82

PDB CODE

6TKO

RESOLUTION

3.3 Å

REFERENCE

10.1038/S41586-020-2419-1

PUBLICATION DATE

June 17, 2020

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

50 interactions (Click to see)

LIGANDS

ARFORMOTEROL - Agonist chembl_ligand chembl_ligand chembl_ligand chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 147 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 F 147 34x51 S5 Y 63 N.S5.12
Polar ICL2 M 153 34x57 s17s18 R 285 C.s17s18.11
Hydrophobic TM2 T 74 2x37 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 Q 150 34x54 S9 C 140 N.S9.01
Polar TM4 T 154 4x38 s17s18 R 285 C.s17s18.11
Hydrophobic TM4 T 154 4x38 s17s18 R 285 C.s17s18.11
Van-der-waals TM4 T 154 4x38 s17s18 R 285 C.s17s18.11
Polar ICL2 Y 149 34x53 s5s6 R 65 N.s5s6.02
Polar TM5 Q 237 5x68 S6 K 77 N.S6.03
Van-der-waals TM5 Q 237 5x68 S6 K 77 N.S6.03
Ionic TM3 R 139 3x50 s5s6 D 69 N.s5s6.06
Polar TM3 R 139 3x50 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 R 139 3x50 s5s6 D 69 N.s5s6.06
Van-der-waals TM3 R 139 3x50 s5s6 D 69 N.s5s6.06
Hydrophobic TM6 A 288 6x33 s5s6 G 72 N.s5s6.09
Hydrophobic ICL2 F 147 34x51 s15s16 L 243 C.s15s16.02
Van-der-waals ICL2 F 147 34x51 s15s16 L 243 C.s15s16.02
Hydrophobic ICL2 P 146 34x50 s15s16 F 244 C.s15s16.03
Van-der-waals TM2 L 75 2x38 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 F 147 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 F 147 34x51 S16 Y 249 C.S16.03
Hydrophobic TM7 Y 343 7x53 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 Y 343 7x53 s5s6 V 70 N.s5s6.07
Ionic ICL1 R 71 12x49 s5s6 D 67 N.s5s6.04
Polar ICL1 R 71 12x49 s5s6 D 67 N.s5s6.04
Van-der-waals ICL1 R 71 12x49 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 F 147 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 F 147 34x51 S15 I 241 C.S15.14
Polar ICL1 Q 73 12x51 s8s9 T 136 N.s8s9.07
Hydrophobic ICL1 Q 73 12x51 s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 Q 73 12x51 s8s9 T 136 N.s8s9.07
Hydrophobic TM3 R 139 3x50 S6 F 75 N.S6.01
Van-der-waals TM3 R 139 3x50 S6 F 75 N.S6.01
Hydrophobic ICL2 Q 150 34x54 S8 L 129 N.S8.03
Polar TM4 R 155 4x39 s8s9 E 134 N.s8s9.05
Hydrophobic TM4 R 155 4x39 s8s9 E 134 N.s8s9.05
Van-der-waals TM4 R 155 4x39 s8s9 E 134 N.s8s9.05
Hydrophobic TM5 K 240 5x71 s15s16 F 244 C.s15s16.03
Polar ICL2 Q 150 34x54 s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 Q 150 34x54 s17s18 R 285 C.s17s18.11
Polar TM6 T 291 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 T 291 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 291 6x36 s5s6 L 71 N.s5s6.08
Aromatic ICL2 F 147 34x51 S5 F 61 N.S5.10
Hydrophobic ICL2 F 147 34x51 S5 F 61 N.S5.10
Van-der-waals ICL2 F 147 34x51 S5 F 61 N.S5.10
Hydrophobic H8 S 346 8x47 s5s6 C 68 N.s5s6.05
Hydrophobic TM5 A 234 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 A 234 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic H8 S 346 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic TM5 K 240 5x71 s15s16 L 243 C.s15s16.02
Van-der-waals TM5 K 240 5x71 s15s16 L 243 C.s15s16.02
Polar ICL2 Q 150 34x54 S5 Y 63 N.S5.12
Van-der-waals ICL2 Q 150 34x54 S5 Y 63 N.S5.12
Hydrophobic TM6 I 295 6x40 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 295 6x40 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 R 139 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 I 241 5x72 S6 K 77 N.S6.03
Van-der-waals TM5 I 241 5x72 S6 K 77 N.S6.03
Polar TM4 R 155 4x39 s8s9 T 136 N.s8s9.07
Hydrophobic TM5 K 240 5x71 s17s18 L 315 C.s17s18.41
Polar TM2 T 74 2x37 s5s6 E 66 N.s5s6.03
Polar TM2 T 76 2x39 s5s6 E 66 N.s5s6.03
Hydrophobic TM2 T 76 2x39 s5s6 E 66 N.s5s6.03
Van-der-waals TM2 T 76 2x39 s5s6 E 66 N.s5s6.03
Hydrophobic TM6 A 288 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 288 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 T 291 6x36 s5s6 V 70 N.s5s6.07
Ionic TM3 R 139 3x50 s5s6 E 66 N.s5s6.03
Polar TM3 R 139 3x50 s5s6 E 66 N.s5s6.03
Hydrophobic TM3 A 142 3x53 S6 F 75 N.S6.01
Hydrophobic ICL2 P 146 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 146 34x50 S5 Y 63 N.S5.12
Polar ICL2 Q 150 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 Q 150 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 Q 150 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM5 Y 227 5x58 s5s6 L 71 N.s5s6.08
Hydrophobic H8 P 347 8x48 s5s6 C 68 N.s5s6.05
Van-der-waals H8 P 347 8x48 s5s6 C 68 N.s5s6.05
Hydrophobic TM3 I 135 3x46 s5s6 V 70 N.s5s6.07
Hydrophobic TM2 I 80 2x43 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 I 80 2x43 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 I 143 3x54 S6 F 75 N.S6.01
Polar ICL2 R 148 34x52 S16 Y 249 C.S16.03
Hydrophobic ICL2 R 148 34x52 S16 Y 249 C.S16.03
Van-der-waals ICL2 R 148 34x52 S16 Y 249 C.S16.03
Hydrophobic TM5 V 230 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 I 143 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 I 143 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 R 139 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 S 151 34x55 s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 S 151 34x55 s17s18 R 285 C.s17s18.11
Hydrophobic TM5 Q 237 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 Q 237 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 L 292 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 292 6x37 s5s6 L 71 N.s5s6.08