GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

R

ARRESTIN (FAMILY)

Beta

ARRESTIN

ARRESTIN SPECIES

Human

ARRESTIN CHAIN

A

ARRESTIN COVERAGE

84

PDB CODE

RESOLUTION

4.9 Å

REFERENCE

PUBLICATION DATE

Dec. 4, 2019

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

CHEMBL48981 - Agonist chembl_ligand pubchem

PHYSIOLOGICAL LIGANDS

neurotensin, neuromedin N, large neurotensin, large neuromedin N



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Arrestin
segment

AA

Number
Generic
number
Polar C-term N 411 - S1 K 10 N.S1.03
Van-der-waals C-term N 411 - S1 K 10 N.S1.03
Polar C-term T 413 - S1 V 8 N.S1.01
Hydrophobic ICL1 Q 95 - S16 Y 249 C.S16.03
Van-der-waals ICL1 Q 95 - S16 Y 249 C.S16.03
Van-der-waals C-term A 412 - S1 V 8 N.S1.01
Van-der-waals C-term S 410 - S1 K 10 N.S1.03