Rhodopsin - S-arrestin

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

D

ARRESTIN (FAMILY)

Visual

ARRESTIN

S-arrestin

ARRESTIN SPECIES

Mouse

ARRESTIN CHAIN

D

ARRESTIN COVERAGE

90

PDB CODE

5W0P

RESOLUTION

3.0 Å

REFERENCE

10.1016/J.CELL.2017.07.002

PUBLICATION DATE

Aug. 9, 2017

3D VIEW

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LIGAND INTERACTIONS

0 interactions (Click to see)

LIGANDS

Apo (no ligand) - Apo (no ligand)

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 142 34x50 s15s16 L 2250 C.s15s16.02
Ionic TM6 K 245 6x28 s9s10 D 2163 N.s9s10.08
Polar TM6 K 245 6x28 s9s10 D 2163 N.s9s10.08
Van-der-waals TM6 K 245 6x28 s9s10 D 2163 N.s9s10.08
Hydrophobic TM6 V 250 6x33 s5s6 T 2079 N.s5s6.11
Hydrophobic ICL2 M 143 34x51 S8 L 2133 N.S8.03
Van-der-waals ICL2 M 143 34x51 S8 L 2133 N.S8.03
Hydrophobic TM3 V 139 3x54 s5s6 T 2079 N.s5s6.11
Hydrophobic ICL2 F 146 34x54 S9 C 2144 N.S9.01
Van-der-waals ICL2 F 146 34x54 S9 C 2144 N.S9.01
Hydrophobic ICL2 P 142 34x50 S15 V 2248 C.S15.14
Van-der-waals ICL2 P 142 34x50 S15 V 2248 C.S15.14
Polar ICL2 N 145 34x53 S5 Y 2068 N.S5.12
Hydrophobic ICL2 N 145 34x53 S5 Y 2068 N.S5.12
Van-der-waals ICL2 N 145 34x53 S5 Y 2068 N.S5.12
Hydrophobic TM6 V 250 6x33 s5s6 L 2078 N.s5s6.10
Van-der-waals TM6 V 250 6x33 s5s6 L 2078 N.s5s6.10
Hydrophobic ICL2 F 146 34x54 s8s9 P 2135 N.s8s9.02
Van-der-waals ICL2 F 146 34x54 s8s9 P 2135 N.s8s9.02
Hydrophobic TM6 V 254 6x37 s5s6 L 2078 N.s5s6.10
Hydrophobic TM3 V 139 3x54 S5 Y 2068 N.S5.12
Polar TM5 Q 236 5x71 S6 R 2082 N.S6.03
Hydrophobic TM3 C 140 3x55 s15s16 Y 2251 C.s15s16.03
Van-der-waals TM3 C 140 3x55 s15s16 Y 2251 C.s15s16.03
Polar H8 Q 312 8x49 s5s6 I 2073 N.s5s6.05
Hydrophobic H8 Q 312 8x49 s5s6 I 2073 N.s5s6.05
Hydrophobic ICL2 F 146 34x54 s8s9 Q 2134 N.s8s9.01
Van-der-waals ICL2 F 146 34x54 s8s9 Q 2134 N.s8s9.01
Hydrophobic TM6 E 249 6x32 s5s6 L 2078 N.s5s6.10
Van-der-waals TM6 E 249 6x32 s5s6 L 2078 N.s5s6.10
Ionic TM3 K 141 3x56 S16 D 2254 C.S16.01
Polar TM3 K 141 3x56 S16 D 2254 C.S16.01
Hydrophobic TM3 K 141 3x56 S16 D 2254 C.S16.01
Van-der-waals TM3 K 141 3x56 S16 D 2254 C.S16.01
Hydrophobic TM3 V 139 3x54 s15s16 Y 2251 C.s15s16.03
Van-der-waals TM3 V 139 3x54 s15s16 Y 2251 C.s15s16.03
Polar TM3 K 141 3x56 s15s16 S 2252 C.s15s16.04
Van-der-waals TM3 K 141 3x56 s15s16 S 2252 C.s15s16.04
Hydrophobic H8 Q 312 8x49 s5s6 M 2076 N.s5s6.08
Van-der-waals H8 Q 312 8x49 s5s6 M 2076 N.s5s6.08
Hydrophobic ICL2 F 146 34x54 S8 L 2133 N.S8.03
Hydrophobic TM5 T 229 5x64 s15s16 Y 2251 C.s15s16.03
Van-der-waals TM5 T 229 5x64 s15s16 Y 2251 C.s15s16.03
Hydrophobic ICL2 P 142 34x50 S5 Y 2068 N.S5.12
Hydrophobic TM2 T 70 2x37 s5s6 I 2073 N.s5s6.05
Van-der-waals TM2 T 70 2x37 s5s6 I 2073 N.s5s6.05
Hydrophobic ICL2 M 143 34x51 S16 Y 2256 C.S16.03
Van-der-waals ICL2 M 143 34x51 S16 Y 2256 C.S16.03
Ionic ICL3 E 239 - s17s18 R 2319 C.s17s18.38
Polar ICL3 E 239 - s17s18 R 2319 C.s17s18.38
Van-der-waals ICL3 E 239 - s17s18 R 2319 C.s17s18.38
Hydrophobic TM6 T 242 6x25 s9s10 D 2163 N.s9s10.08
Polar TM5 Q 237 5x72 S6 D 2083 N.S6.04
Van-der-waals TM5 Q 237 5x72 S6 D 2083 N.S6.04
Hydrophobic TM2 L 72 2x39 s5s6 I 2073 N.s5s6.05
Van-der-waals TM2 L 72 2x39 s5s6 I 2073 N.s5s6.05
Polar TM5 Q 237 5x72 S6 R 2082 N.S6.03
Hydrophobic TM5 Q 237 5x72 S6 R 2082 N.S6.03
Van-der-waals TM5 Q 237 5x72 S6 R 2082 N.S6.03
Polar TM5 A 233 5x68 S6 R 2082 N.S6.03
Hydrophobic TM5 A 233 5x68 S6 R 2082 N.S6.03
Van-der-waals TM5 A 233 5x68 S6 R 2082 N.S6.03
Hydrophobic ICL2 P 142 34x50 S5 F 2066 N.S5.10
Van-der-waals ICL2 P 142 34x50 S5 F 2066 N.S5.10
Hydrophobic ICL2 F 146 34x54 s8s9 S 2143 N.s8s9.10
Hydrophobic TM4 G 149 4x38 s8s9 K 2142 N.s8s9.09
Hydrophobic TM5 Q 237 5x72 s17s18 M 2322 C.s17s18.41
Van-der-waals TM5 Q 237 5x72 s17s18 M 2322 C.s17s18.41
Polar TM5 Q 237 5x72 S6 L 2084 N.S6.05
Van-der-waals TM5 Q 237 5x72 S6 L 2084 N.S6.05
Hydrophobic TM6 M 253 6x36 s5s6 L 2078 N.s5s6.10
Van-der-waals TM6 M 253 6x36 s5s6 L 2078 N.s5s6.10
Polar ICL2 F 146 34x54 s8s9 K 2142 N.s8s9.09
Hydrophobic ICL2 F 146 34x54 s8s9 K 2142 N.s8s9.09
Van-der-waals ICL2 F 146 34x54 s8s9 K 2142 N.s8s9.09
Hydrophobic H8 Q 312 8x49 s5s6 D 2072 N.s5s6.04
Hydrophobic ICL2 N 145 34x53 s5s6 G 2069 N.s5s6.01
Van-der-waals ICL2 N 145 34x53 s5s6 G 2069 N.s5s6.01
Hydrophobic ICL2 F 148 34x56 s8s9 K 2142 N.s8s9.09
Hydrophobic ICL2 M 143 34x51 S15 V 2248 C.S15.14
Hydrophobic TM5 A 233 5x68 s15s16 Y 2251 C.s15s16.03