Rhodopsin - S-arrestin

GPCR CLASS (FAMILY)

Class A (Rhodopsin)

GPCR SPECIES

Bos taurus

GPCR PREFERRED CHAIN

A

ARRESTIN (FAMILY)

Visual

ARRESTIN

ARRESTIN SPECIES

Mouse

ARRESTIN CHAIN

B

ARRESTIN COVERAGE

2

PDB CODE

RESOLUTION

2.8 Å

REFERENCE

PUBLICATION DATE

Sept. 17, 2014

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

LIGANDS

B-Octylglucoside - unknown pubchem

PHYSIOLOGICAL LIGANDS

No physiological ligands available



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type
GPCR
Segment

AA

Number
Generic
number
Arrestin
segment

AA

Number
Generic
number
Hydrophobic TM3 V 139 3x54 s5s6 I 72 N.s5s6.05
Hydrophobic TM5 L 226 5x61 s5s6 M 75 N.s5s6.08
Hydrophobic TM3 V 138 3x53 s5s6 I 72 N.s5s6.05
Polar H8 N 310 8x47 s5s6 G 76 N.s5s6.09
Hydrophobic H8 N 310 8x47 s5s6 G 76 N.s5s6.09
Van-der-waals H8 N 310 8x47 s5s6 G 76 N.s5s6.09
Polar H8 K 311 8x48 s5s6 G 76 N.s5s6.09
Van-der-waals H8 K 311 8x48 s5s6 G 76 N.s5s6.09
Hydrophobic H8 K 311 8x48 s5s6 L 77 N.s5s6.10
Hydrophobic TM6 E 249 6x32 s5s6 L 77 N.s5s6.10
Van-der-waals TM6 E 249 6x32 s5s6 L 77 N.s5s6.10
Hydrophobic TM6 V 250 6x33 s5s6 L 77 N.s5s6.10
Van-der-waals TM6 V 250 6x33 s5s6 L 77 N.s5s6.10
Polar TM3 R 135 3x50 s5s6 M 75 N.s5s6.08
Hydrophobic TM3 R 135 3x50 s5s6 M 75 N.s5s6.08
Van-der-waals TM3 R 135 3x50 s5s6 M 75 N.s5s6.08
Hydrophobic TM6 M 253 6x36 s5s6 L 77 N.s5s6.10