Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
drd2_human 3.32x32 114 TM3 D => N N/A N/A Mansour A et al (1992)
drd2_human 3.32x32 114 TM3 D => G N/A N/A Mansour A et al (1992)
drd2_human 3.34x34 116 TM3 M => L N/A N/A Mansour A et al (1992)
drd2_human 3.35x35 117 TM3 M => L N/A N/A Mansour A et al (1992)
drd2_human 3.35x35 117 TM3 M => C N/A N/A Mansour A et al (1992)
drd2_human 5.43x44 194 TM5 S => A N/A N/A Mansour A et al (1992)
drd2_human 5.46x461 197 TM5 S => A N/A N/A Mansour A et al (1992)
drd2_human 1.54x54 56 TM1 C => S N/A N/A Javitch JA et al (1994)
drd2_human 3.36x36 118 TM3 C => S N/A N/A Javitch JA et al (1994)
drd2_human 3.44x44 126 TM3 C => S N/A N/A Javitch JA et al (1994)
drd2_human 4.58x59 168 TM4 C => S N/A N/A Javitch JA et al (1994)
drd2_human 6.47x47 385 TM6 C => S N/A N/A Javitch JA et al (1994)
drd2_human 249 ICL3 D => V N/A N/A Guiramand J et al (1995)
drd2_human 264 ICL3 P => G N/A N/A Guiramand J et al (1995)
drd2_human 3.36x36 118 TM3 C => S N/A N/A Javitch JA et al (1995)
drd2_human 3.36x36 118 TM3 C => K N/A N/A Javitch JA et al (1996)
drd2_human 3.36x36 118 TM3 C => M N/A N/A Javitch JA et al (1996)
drd2_human 3.36x36 118 TM3 C => S N/A N/A Javitch JA et al (1996)
drd2_human 3.36x36 118 TM3 C => A N/A N/A Javitch JA et al (1996)
drd2_human 5.47x47 198 TM5 F => A N/A N/A Cho W et al (1995)
drd2_human 6.51x51 389 TM6 F => A N/A N/A Cho W et al (1995)
drd2_human 6.52x52 390 TM6 F => A N/A N/A Cho W et al (1995)
drd2_human 7.38x37 411 TM7 F => A N/A N/A Cho W et al (1995)
drd2_human 6.49x49 387 TM6 L => A N/A N/A Cho W et al (1995)
drd2_human 3.36x36 118 TM3 C => S N/A N/A Javitch JA et al (1998)
drd2_human 2.60x59 90 TM2 W => L N/A N/A Simpson MM et al (1999)
drd2_human 2.61x60 91 TM2 V => F N/A N/A Simpson MM et al (1999)
drd2_human 2.64x63 94 TM2 L => S N/A N/A Simpson MM et al (1999)
drd2_human 3.28x28 110 TM3 F => L N/A N/A Simpson MM et al (1999)
drd2_human 3.29x29 111 TM3 V => M N/A N/A Simpson MM et al (1999)
drd2_human 5.38x39 189 TM5 F => Y N/A N/A Simpson MM et al (1999)
drd2_human 5.45x46 196 TM5 V => C N/A N/A Simpson MM et al (1999)
drd2_human 6.54x54 392 TM6 T => V N/A N/A Simpson MM et al (1999)
drd2_human 7.35x34 408 TM7 Y => V N/A N/A Simpson MM et al (1999)
drd2_human 7.38x37 411 TM7 F => V N/A N/A Simpson MM et al (1999)
drd2_human 3.36x36 118 TM3 C => S N/A N/A Javitch JA et al (1999)
drd2_human 3.32x32 114 TM3 D => N N/A N/A Lee SP et al (2000)
drd2_human 3.36x36 118 TM3 C => S N/A N/A Javitch JA et al (2000)
drd2_human 2 N-term D => S N/A N/A Kim KM et al (2001)
drd2_human 5 N-term N => A N/A N/A Lee SP et al (2003)
drd2_human 17 N-term N => A N/A N/A Lee SP et al (2003)
drd2_human 23 N-term N => A N/A N/A Lee SP et al (2003)
drd2_human 2.47x47 77 TM2 A => C N/A N/A Javitch JA et al (1999)
drd2_human 2.48x48 78 TM2 V => C N/A N/A Javitch JA et al (1999)
drd2_human 2.49x49 79 TM2 A => C N/A N/A Javitch JA et al (1999)
drd2_human 2.50x50 80 TM2 D => C N/A N/A Javitch JA et al (1999)
drd2_human 2.51x51 81 TM2 L => C N/A N/A Javitch JA et al (1999)
drd2_human 2.52x52 82 TM2 L => C N/A N/A Javitch JA et al (1999)
drd2_human 2.53x53 83 TM2 V => C N/A N/A Javitch JA et al (1999)
drd2_human 2.54x54 84 TM2 A => C N/A N/A Javitch JA et al (1999)
drd2_human 2.55x55 85 TM2 T => C N/A N/A Javitch JA et al (1999)
drd2_human 2.56x551 86 TM2 L => C N/A N/A Javitch JA et al (1999)
drd2_human 2.57x56 87 TM2 V => C N/A N/A Javitch JA et al (1999)
drd2_human 2.58x57 88 TM2 M => C N/A N/A Javitch JA et al (1999)
drd2_human 2.59x58 89 TM2 P => C N/A N/A Javitch JA et al (1999)
drd2_human 2.60x59 90 TM2 W => C N/A N/A Javitch JA et al (1999)
drd2_human 2.60x59 90 TM2 W => L N/A N/A Simpson MM et al (1999)
drd2_human 2.61x60 91 TM2 V => C N/A N/A Javitch JA et al (1999)
drd2_human 2.61x60 91 TM2 V => F N/A N/A Simpson MM et al (1999)
drd2_human 2.62x61 92 TM2 V => C N/A N/A Javitch JA et al (1999)
drd2_human 2.63x62 93 TM2 Y => C N/A N/A Javitch JA et al (1999)
drd2_human 2.64x63 94 TM2 L => C N/A N/A Javitch JA et al (1999)
drd2_human 2.64x63 94 TM2 L => S N/A N/A Simpson MM et al (1999)
drd2_human 2.65x64 95 TM2 E => C N/A N/A Javitch JA et al (1999)
drd2_human 2.66x65 96 TM2 V => A N/A N/A Kaiser R et al (2003)
drd2_human 2.66x65 96 TM2 V => C N/A N/A Javitch JA et al (1999)
drd2_human 2.67x66 97 TM2 V => C N/A N/A Javitch JA et al (1999)
drd2_human 2.68x67 98 TM2 G => C N/A N/A Javitch JA et al (1999)
drd2_human 3.26x26 108 TM3 D => C N/A N/A Javitch JA et al (1999)
drd2_human 3.28x28 110 TM3 F => L N/A N/A Simpson MM et al (1999)
drd2_human 3.29x29 111 TM3 V => M N/A N/A Simpson MM et al (1999)
drd2_human 3.32x32 114 TM3 D => C N/A N/A Javitch JA et al (1999)
drd2_human 3.32x32 114 TM3 D => N N/A N/A Lee SP et al (2000)
drd2_human 3.32x32 114 TM3 D => S N/A N/A Kalani MY et al (2004)
drd2_human 3.36x36 118 TM3 C => K N/A N/A Javitch JA et al (1996)
drd2_human 3.36x36 118 TM3 C => S N/A N/A Javitch JA et al (1999)
drd2_human 3.36x36 118 TM3 C => S N/A N/A Javitch JA et al (1994)
drd2_human 3.36x36 118 TM3 C => S N/A N/A Javitch JA et al (1998)
drd2_human 4.44x44 154 TM4 V => I N/A N/A Klein C et al (1999)
drd2_human 4.44x44 154 TM4 V => I N/A N/A Klein C et al (2000)
drd2_human 4.44x44 154 TM4 V => I N/A N/A Grimes DA et al (2001)
drd2_human 4.44x44 154 TM4 V => I N/A N/A Vidailhet M et al (2001)
drd2_human 4.45x45 155 TM4 M => P N/A N/A Lee SP et al (2003)
drd2_human 4.57x57 167 TM4 S => A N/A N/A Simpson MM et al (1999)
drd2_human 4.62x63 172 TM4 F => C N/A N/A Simpson MM et al (1999)
drd2_human 45.50x50 182 ECL2 C => A N/A N/A Lee SP et al (2003)
drd2_human 5.38x39 189 TM5 F => Y N/A N/A Simpson MM et al (1999)
drd2_human 5.43x44 194 TM5 S => A N/A N/A Lee SP et al (2000)
drd2_human 5.46x461 197 TM5 S => A N/A N/A Lee SP et al (2000)
drd2_human 264 ICL3 P => G N/A N/A Guiramand J et al (1995)
drd2_human 310 ICL3 P => S N/A N/A Kaiser R et al (2003)
drd2_human 311 ICL3 S => C N/A N/A Kaiser R et al (2003)
drd2_human 311 ICL3 S => C N/A N/A Goldman D et al (1997)
drd2_human 6.33x33 371 TM6 A => K N/A N/A Pauwels PJ et al (2001)
drd2_human 6.34x34 372 TM6 T => R N/A N/A Pauwels PJ et al (2001)
drd2_human 6.34x34 372 TM6 T => R N/A N/A Wurch T et al (2003)
drd2_human 6.35x35 373 TM6 Q => K N/A N/A Pauwels PJ et al (2001)
drd2_human 6.39x39 377 TM6 I => C N/A N/A Javitch JA et al (1998)
drd2_human 6.40x40 378 TM6 V => C N/A N/A Javitch JA et al (1998)
drd2_human 6.41x41 379 TM6 L => C N/A N/A Javitch JA et al (1998)
drd2_human 6.42x42 380 TM6 G => C N/A N/A Javitch JA et al (1998)
drd2_human 6.43x43 381 TM6 V => C N/A N/A Javitch JA et al (1998)
drd2_human 6.44x44 382 TM6 F => C N/A N/A Javitch JA et al (1998)
drd2_human 6.45x45 383 TM6 I => C N/A N/A Javitch JA et al (1998)
drd2_human 6.46x46 384 TM6 I => C N/A N/A Javitch JA et al (1998)
drd2_human 6.48x48 386 TM6 W => C N/A N/A Javitch JA et al (1998)
drd2_human 6.49x49 387 TM6 L => C N/A N/A Javitch JA et al (1998)
drd2_human 6.50x50 388 TM6 P => C N/A N/A Javitch JA et al (1998)
drd2_human 6.51x51 389 TM6 F => C N/A N/A Javitch JA et al (1999)
drd2_human 6.51x51 389 TM6 F => C N/A N/A Javitch JA et al (1998)
drd2_human 6.52x52 390 TM6 F => A N/A N/A Javitch JA et al (1998)
drd2_human 6.52x52 390 TM6 F => C N/A N/A Javitch JA et al (1999)
drd2_human 6.52x52 390 TM6 F => C N/A N/A Javitch JA et al (1998)
drd2_human 6.53x53 391 TM6 I => C N/A N/A Javitch JA et al (1998)
drd2_human 6.54x54 392 TM6 T => C N/A N/A Javitch JA et al (1998)
drd2_human 6.55x55 393 TM6 H => C N/A N/A Javitch JA et al (1998)
drd2_human 6.56x56 394 TM6 I => C N/A N/A Javitch JA et al (1998)
drd2_human 6.57x57 395 TM6 L => C N/A N/A Javitch JA et al (1998)
drd2_human 6.58x58 396 TM6 N => C N/A N/A Javitch JA et al (1998)
drd2_human 6.59x59 397 TM6 I => C N/A N/A Javitch JA et al (1998)
drd2_human 6.60x60 398 TM6 H => C N/A N/A Javitch JA et al (1998)
drd2_human 7.35x34 408 TM7 Y => V N/A N/A Simpson MM et al (1999)
drd2_human 7.39x38 412 TM7 T => C N/A N/A Javitch JA et al (1999)
drd2_human 7.39x38 412 TM7 T => C N/A N/A Javitch JA et al (1998)
drd2_human 7.35x34 408 TM7 Y => V N/A N/A Simpson MM et al (1999)
drd2_human 7.35x34 408 TM7 Y => V N/A N/A Simpson MM et al (1999)
drd2_human 7.35x34 408 TM7 Y => V N/A N/A Simpson MM et al (1999)
drd2_human 5.38x39 189 TM5 F => Y N/A N/A Simpson MM et al (1999)
drd2_human 5.38x39 189 TM5 F => Y N/A N/A Simpson MM et al (1999)
drd2_human 5.38x39 189 TM5 F => Y N/A N/A Simpson MM et al (1999)
drd2_human 3.28x28 110 TM3 F => L N/A N/A Simpson MM et al (1999)
drd2_human 3.28x28 110 TM3 F => L N/A N/A Simpson MM et al (1999)
drd2_human 3.28x28 110 TM3 F => L N/A N/A Simpson MM et al (1999)
drd2_human 2.61x60 91 TM2 V => F N/A N/A Simpson MM et al (1999)
drd2_human 2.61x60 91 TM2 V => F N/A N/A Simpson MM et al (1999)
drd2_human 2.61x60 91 TM2 V => F N/A N/A Simpson MM et al (1999)
drd2_human 3.48x48 130 TM3 I => C N/A N/A Javitch JA et al (1995)
drd2_human 3.47x47 129 TM3 S => C N/A N/A Javitch JA et al (1995)
drd2_human 3.46x46 128 TM3 I => C N/A N/A Javitch JA et al (1995)
drd2_human 3.45x45 127 TM3 A => C N/A N/A Javitch JA et al (1995)
drd2_human 3.43x43 125 TM3 L => C N/A N/A Javitch JA et al (1995)
drd2_human 3.42x42 124 TM3 N => C N/A N/A Javitch JA et al (1995)
drd2_human 3.41x41 123 TM3 L => C N/A N/A Javitch JA et al (1995)
drd2_human 3.40x40 122 TM3 I => C N/A N/A Javitch JA et al (1995)
drd2_human 3.39x39 121 TM3 S => C N/A N/A Javitch JA et al (1995)
drd2_human 3.38x38 120 TM3 A => C N/A N/A Javitch JA et al (1995)
drd2_human 3.37x37 119 TM3 T => C N/A N/A Javitch JA et al (1995)
drd2_human 3.35x35 117 TM3 M => C N/A N/A Javitch JA et al (1995)
drd2_human 3.34x34 116 TM3 M => C N/A N/A Javitch JA et al (1995)
drd2_human 3.33x33 115 TM3 V => C N/A N/A Javitch JA et al (1995)
drd2_human 3.31x31 113 TM3 L => C N/A N/A Javitch JA et al (1995)
drd2_human 3.30x30 112 TM3 T => C N/A N/A Javitch JA et al (1995)
drd2_human 3.29x29 111 TM3 V => C N/A N/A Javitch JA et al (1995)
drd2_human 3.28x28 110 TM3 F => C N/A N/A Javitch JA et al (1995)
drd2_human 3.27x27 109 TM3 I => C N/A N/A Javitch JA et al (1995)
drd2_human 3.26x26 108 TM3 D => C N/A N/A Javitch JA et al (1995)
drd2_human 3.26x26 108 TM3 D => C N/A N/A Javitch JA et al (1995)
drd2_human 3.37x37 119 TM3 T => C N/A N/A Gao ZG et al (2002)
drd2_human 4.39x39 149 TM4 K => C N/A N/A Lan H et al (2009)
drd2_human 4.43x43 153 TM4 T => A N/A N/A Lan H et al (2009)
drd2_human 2.64x63 94 TM2 L => A 5.291↓ K(d) (Binding - Radioligand kinetics (association/dissociation)) aripiprazole Wang S et al (2018) Vass M et al (2019)
drd2_human 23.50x50 100 ECL1 W => A 28.571↓ K(d) (Binding - Radioligand kinetics (association/dissociation)) aripiprazole Wang S et al (2018) Vass M et al (2019)
drd2_human 23.50x50 100 ECL1 W => F 6.667↓ K(d) (Binding - Radioligand kinetics (association/dissociation)) aripiprazole Wang S et al (2018) Vass M et al (2019)
drd2_human 23.50x50 100 ECL1 W => L 41.667↓ K(d) (Binding - Radioligand kinetics (association/dissociation)) aripiprazole Wang S et al (2018) Vass M et al (2019)
drd2_human 45.52x52 184 ECL2 I => A 1.645↓ K(d) (Binding - Radioligand kinetics (association/dissociation)) aripiprazole Wang S et al (2018) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => A 1.778↑ pK(0.5) (Binding - Radioligand competition/displacement) aripiprazole Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => F 4.266↑ pK(0.5) (Binding - Radioligand competition/displacement) aripiprazole Tschammer N et al (2011) Vass M et al (2019)
drd2_human 5.42x43 193 TM5 S => A 4.587↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL124561 Fowler JC et al (2012) Vass M et al (2019)
drd2_human 5.43x44 194 TM5 S => A 5.208↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL124561 Fowler JC et al (2012) Vass M et al (2019)
drd2_human 5.46x461 197 TM5 S => A 2.294↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL124561 Fowler JC et al (2012) Vass M et al (2019)
drd2_human 5.47x47 198 TM5 F => A Abolishment K(d) (Binding - Radioligand saturation) rotigotine Cho W et al (1995) Vass M et al (2019)
drd2_human 6.49x49 387 TM6 L => A 1.417↑ K(d) (Binding - Radioligand saturation) rotigotine Cho W et al (1995) Vass M et al (2019)
drd2_human 6.51x51 389 TM6 F => A Abolishment K(d) (Binding - Radioligand saturation) rotigotine Cho W et al (1995) Vass M et al (2019)
drd2_human 6.52x52 390 TM6 F => A Abolishment K(d) (Binding - Radioligand saturation) rotigotine Cho W et al (1995) Vass M et al (2019)
drd2_human 7.38x37 411 TM7 F => A 1.417↑ K(d) (Binding - Radioligand saturation) rotigotine Cho W et al (1995) Vass M et al (2019)
drd2_human 2.64x63 94 TM2 L => A 4.202↓ K(d) (Binding - Radioligand kinetics (association/dissociation)) nemonapride Wang S et al (2018) Vass M et al (2019)
drd2_human 23.50x50 100 ECL1 W => A 6.135↓ K(d) (Binding - Radioligand kinetics (association/dissociation)) nemonapride Wang S et al (2018) Vass M et al (2019)
drd2_human 23.50x50 100 ECL1 W => A 9.346↓ K(d) (Binding - Radioligand competition/displacement) nemonapride Wang S et al (2018) Vass M et al (2019)
drd2_human 23.50x50 100 ECL1 W => F 4.202↓ K(d) (Binding - Radioligand kinetics (association/dissociation)) nemonapride Wang S et al (2018) Vass M et al (2019)
drd2_human 23.50x50 100 ECL1 W => L 6.452↓ K(d) (Binding - Radioligand kinetics (association/dissociation)) nemonapride Wang S et al (2018) Vass M et al (2019)
drd2_human 3.28x28 110 TM3 F => A 1.235↑ K(d) (Binding - Radioligand competition/displacement) nemonapride Wang S et al (2018) Vass M et al (2019)
drd2_human 3.32x32 114 TM3 D => A 38.462↓ K(d) (Binding - Radioligand competition/displacement) nemonapride Wang S et al (2018) Vass M et al (2019)
drd2_human 3.33x33 115 TM3 V => A 4.0↓ K(d) (Binding - Radioligand competition/displacement) nemonapride Wang S et al (2018) Vass M et al (2019)
drd2_human 3.36x36 118 TM3 C => A 1.905↓ K(d) (Binding - Radioligand competition/displacement) nemonapride Wang S et al (2018) Vass M et al (2019)
drd2_human 3.37x37 119 TM3 T => A 2.049↓ K(d) (Binding - Radioligand competition/displacement) nemonapride Wang S et al (2018) Vass M et al (2019)
drd2_human 3.40x40 122 TM3 I => A 1.429↓ K(d) (Binding - Radioligand competition/displacement) nemonapride Wang S et al (2018) Vass M et al (2019)
drd2_human 45.52x52 184 ECL2 I => A 2.257↓ K(d) (Binding - Radioligand kinetics (association/dissociation)) nemonapride Wang S et al (2018) Vass M et al (2019)
drd2_human 5.46x461 197 TM5 S => A 2.049↓ K(d) (Binding - Radioligand competition/displacement) nemonapride Wang S et al (2018) Vass M et al (2019)
drd2_human 5.47x47 198 TM5 F => A 3.623↓ K(d) (Binding - Radioligand competition/displacement) nemonapride Wang S et al (2018) Vass M et al (2019)
drd2_human 6.44x44 382 TM6 F => A 1.429↓ K(d) (Binding - Radioligand competition/displacement) nemonapride Wang S et al (2018) Vass M et al (2019)
drd2_human 6.48x48 386 TM6 W => A 19.231↓ K(d) (Binding - Radioligand competition/displacement) nemonapride Wang S et al (2018) Vass M et al (2019)
drd2_human 6.51x51 389 TM6 F => A 22.222↓ K(d) (Binding - Radioligand competition/displacement) nemonapride Wang S et al (2018) Vass M et al (2019)
drd2_human 6.52x52 390 TM6 F => A 6.173↓ K(d) (Binding - Radioligand competition/displacement) nemonapride Wang S et al (2018) Vass M et al (2019)
drd2_human 7.35x34 408 TM7 Y => A 1.167↑ K(d) (Binding - Radioligand competition/displacement) nemonapride Wang S et al (2018) Vass M et al (2019)
drd2_human 7.39x38 412 TM7 T => A 23.256↓ K(d) (Binding - Radioligand competition/displacement) nemonapride Wang S et al (2018) Vass M et al (2019)
drd2_human 7.43x42 416 TM7 Y => A 4.184↓ K(d) (Binding - Radioligand competition/displacement) nemonapride Wang S et al (2018) Vass M et al (2019)
drd2_human 5.47x47 198 TM5 F => A 1.045↓ K(i) (Binding - Radioligand competition/displacement) (-)-N-porphynorapomorphine Cho W et al (1995) Vass M et al (2019)
drd2_human 6.49x49 387 TM6 L => A 1.546↓ K(i) (Binding - Radioligand competition/displacement) (-)-N-porphynorapomorphine Cho W et al (1995) Vass M et al (2019)
drd2_human 6.51x51 389 TM6 F => A 333.333↓ K(i) (Binding - Radioligand competition/displacement) (-)-N-porphynorapomorphine Cho W et al (1995) Vass M et al (2019)
drd2_human 7.38x37 411 TM7 F => A 1.136↓ K(i) (Binding - Radioligand competition/displacement) (-)-N-porphynorapomorphine Cho W et al (1995) Vass M et al (2019)
drd2_human 1.54x54 56 TM1 C => S 2.0↑ K(d) (Binding - Radioligand saturation) [3H]NEMONAPRIDE Javitch JA et al (1994) Vass M et al (2019)
drd2_human 3.36x36 118 TM3 C => S 1.812↓ K(d) (Binding - Radioligand saturation) [3H]NEMONAPRIDE Javitch JA et al (1995) Vass M et al (2019)
drd2_human 3.36x36 118 TM3 C => S 1.385↓ K(d) (Binding - Radioligand saturation) [3H]NEMONAPRIDE Javitch JA et al (1994) Vass M et al (2019)
drd2_human 3.44x44 126 TM3 C => S 1.529↑ K(d) (Binding - Radioligand saturation) [3H]NEMONAPRIDE Javitch JA et al (1994) Vass M et al (2019)
drd2_human 4.58x59 168 TM4 C => S 1.444↑ K(d) (Binding - Radioligand saturation) [3H]NEMONAPRIDE Javitch JA et al (1994) Vass M et al (2019)
drd2_human 6.47x47 385 TM6 C => S 1.529↑ K(d) (Binding - Radioligand saturation) [3H]NEMONAPRIDE Javitch JA et al (1994) Vass M et al (2019)
drd2_human 6.52x52 390 TM6 F => W 10.753↓ K(i) (Binding - Radioligand competition/displacement) [3H]NEMONAPRIDE Tschammer N et al (2010) Vass M et al (2019)
drd2_human 5.42x43 193 TM5 S => A 2.849↓ K(i) (Binding - Radioligand competition/displacement) quinpirole Fowler JC et al (2012) Vass M et al (2019)
drd2_human 5.43x44 194 TM5 S => A 71.429↓ K(i) (Binding - Radioligand competition/displacement) quinpirole Fowler JC et al (2012) Vass M et al (2019)
drd2_human 5.46x461 197 TM5 S => A 7.937↓ K(i) (Binding - Radioligand competition/displacement) quinpirole Fowler JC et al (2012) Vass M et al (2019)
drd2_human 6.52x52 390 TM6 F => W 4.098↓ K(0.5) (Binding - Radioligand competition/displacement) quinpirole Tschammer N et al (2010) Vass M et al (2019)
drd2_human 6.52x52 390 TM6 F => W 1.692↓ K(h) (Binding - Radioligand competition/displacement) quinpirole Tschammer N et al (2010) Vass M et al (2019)
drd2_human 6.52x52 390 TM6 F => W 2.381↓ K(l) (Binding - Radioligand competition/displacement) quinpirole Tschammer N et al (2010) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => A 17.857↓ pK(0.5) (Binding - Radioligand competition/displacement) quinpirole Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => F 1.995↑ pK(0.5) (Binding - Radioligand competition/displacement) quinpirole Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => A 62.5↓ pK(h) (Binding - Radioligand competition/displacement) quinpirole Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => F 1.175↑ pK(h) (Binding - Radioligand competition/displacement) quinpirole Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => A 18.182↓ pK(l) (Binding - Radioligand competition/displacement) quinpirole Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => F 1.905↑ pK(l) (Binding - Radioligand competition/displacement) quinpirole Tschammer N et al (2011) Vass M et al (2019)
drd2_human 5.42x43 193 TM5 S => A 15.152↓ K(i) (Binding - Radioligand competition/displacement) DIHYDREXIDINE Fowler JC et al (2012) Vass M et al (2019)
drd2_human 5.43x44 194 TM5 S => A 5.319↓ K(i) (Binding - Radioligand competition/displacement) DIHYDREXIDINE Fowler JC et al (2012) Vass M et al (2019)
drd2_human 5.46x461 197 TM5 S => A 3.268↓ K(i) (Binding - Radioligand competition/displacement) DIHYDREXIDINE Fowler JC et al (2012) Vass M et al (2019)
drd2_human 3.36x36 118 TM3 C => A No effect K(i) (Binding - Radioligand competition/displacement) (+)-sulpiride Simpson MM et al (1999) Vass M et al (2019)
drd2_human 3.36x36 118 TM3 C => K ~10000.0↑ K(i) (Binding - Radioligand competition/displacement) (+)-sulpiride Simpson MM et al (1999) Vass M et al (2019)
drd2_human 3.36x36 118 TM3 C => M No effect K(i) (Binding - Radioligand competition/displacement) (+)-sulpiride Simpson MM et al (1999) Vass M et al (2019)
drd2_human 3.36x36 118 TM3 C => S No effect K(i) (Binding - Radioligand competition/displacement) (+)-sulpiride Simpson MM et al (1999) Vass M et al (2019)
drd2_human 5.47x47 198 TM5 F => A 1.096↓ K(d) (Binding - Radioligand saturation) spiperone Cho W et al (1995) Vass M et al (2019)
drd2_human 6.49x49 387 TM6 L => A 1.025↓ K(d) (Binding - Radioligand saturation) spiperone Cho W et al (1995) Vass M et al (2019)
drd2_human 6.51x51 389 TM6 F => A 33.333↓ K(d) (Binding - Radioligand saturation) spiperone Cho W et al (1995) Vass M et al (2019)
drd2_human 6.52x52 390 TM6 F => A Abolishment K(d) (Binding - Radioligand saturation) spiperone Cho W et al (1995) Vass M et al (2019)
drd2_human 7.38x37 411 TM7 F => A 1.361↑ K(d) (Binding - Radioligand saturation) spiperone Cho W et al (1995) Vass M et al (2019)
drd2_human 6.52x52 390 TM6 F => W 1.555↓ K(i) (Binding - Radioligand competition/displacement) spiperone Tschammer N et al (2010) Vass M et al (2019)
drd2_human 3.36x36 118 TM3 C => A ~2.0↑ K(d) (Binding - Radioligand saturation) MESPIPERONE Simpson MM et al (1999) Vass M et al (2019)
drd2_human 3.36x36 118 TM3 C => K ~10.0↑ K(d) (Binding - Radioligand saturation) MESPIPERONE Simpson MM et al (1999) Vass M et al (2019)
drd2_human 3.36x36 118 TM3 C => M ~5.0↑ K(d) (Binding - Radioligand saturation) MESPIPERONE Simpson MM et al (1999) Vass M et al (2019)
drd2_human 3.36x36 118 TM3 C => S ~2.0↑ K(d) (Binding - Radioligand saturation) MESPIPERONE Simpson MM et al (1999) Vass M et al (2019)
drd2_human 2.60x59 90 TM2 W => L 1.898↓ K(d) (Binding - Radioligand saturation) MESPIPERONE Simpson MM et al (1999) Vass M et al (2019)
drd2_human 2.61x60 91 TM2 V => F 2.821↑ K(d) (Binding - Radioligand saturation) MESPIPERONE Simpson MM et al (1999) Vass M et al (2019)
drd2_human 2.64x63 94 TM2 L => S 3.802↓ K(d) (Binding - Radioligand saturation) MESPIPERONE Simpson MM et al (1999) Vass M et al (2019)
drd2_human 2.64x63 94 TM2 L => A 3.448↓ K(d) (Binding - Radioligand kinetics (association/dissociation)) MESPIPERONE Wang S et al (2018) Vass M et al (2019)
drd2_human 23.50x50 100 ECL1 W => A 17.241↓ K(d) (Binding - Radioligand kinetics (association/dissociation)) MESPIPERONE Wang S et al (2018) Vass M et al (2019)
drd2_human 23.50x50 100 ECL1 W => F 7.246↓ K(d) (Binding - Radioligand kinetics (association/dissociation)) MESPIPERONE Wang S et al (2018) Vass M et al (2019)
drd2_human 23.50x50 100 ECL1 W => L 16.129↓ K(d) (Binding - Radioligand kinetics (association/dissociation)) MESPIPERONE Wang S et al (2018) Vass M et al (2019)
drd2_human 3.28x28 110 TM3 F => L 2.915↓ K(d) (Binding - Radioligand saturation) MESPIPERONE Simpson MM et al (1999) Vass M et al (2019)
drd2_human 3.29x29 111 TM3 V => M 11.494↓ K(d) (Binding - Radioligand saturation) MESPIPERONE Simpson MM et al (1999) Vass M et al (2019)
drd2_human 45.52x52 184 ECL2 I => A 2.667↓ K(d) (Binding - Radioligand kinetics (association/dissociation)) MESPIPERONE Wang S et al (2018) Vass M et al (2019)
drd2_human 5.38x39 189 TM5 F => Y 2.394↑ K(d) (Binding - Radioligand saturation) MESPIPERONE Simpson MM et al (1999) Vass M et al (2019)
drd2_human 5.45x46 196 TM5 V => C 1.393↓ K(d) (Binding - Radioligand saturation) MESPIPERONE Simpson MM et al (1999) Vass M et al (2019)
drd2_human 6.54x54 392 TM6 T => V 1.393↓ K(d) (Binding - Radioligand saturation) MESPIPERONE Simpson MM et al (1999) Vass M et al (2019)
drd2_human 7.35x34 408 TM7 Y => V 3.922↓ K(d) (Binding - Radioligand saturation) MESPIPERONE Simpson MM et al (1999) Vass M et al (2019)
drd2_human 7.38x37 411 TM7 F => V 1.29↓ K(d) (Binding - Radioligand saturation) MESPIPERONE Simpson MM et al (1999) Vass M et al (2019)
drd2_human 6.52x52 390 TM6 F => W 32.258↓ K(0.5) (Binding - Radioligand competition/displacement) 7-OH-DPAT Tschammer N et al (2010) Vass M et al (2019)
drd2_human 6.52x52 390 TM6 F => W 19.231↓ K(h) (Binding - Radioligand competition/displacement) 7-OH-DPAT Tschammer N et al (2010) Vass M et al (2019)
drd2_human 6.52x52 390 TM6 F => W 29.412↓ K(l) (Binding - Radioligand competition/displacement) 7-OH-DPAT Tschammer N et al (2010) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => A 17.241↓ pK(0.5) (Binding - Radioligand competition/displacement) 7-OH-DPAT Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => F 1.289↓ pK(0.5) (Binding - Radioligand competition/displacement) 7-OH-DPAT Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => A 11.765↓ pK(h) (Binding - Radioligand competition/displacement) 7-OH-DPAT Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => F 1.548↓ pK(h) (Binding - Radioligand competition/displacement) 7-OH-DPAT Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => A 14.706↓ pK(l) (Binding - Radioligand competition/displacement) 7-OH-DPAT Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => F 1.259↓ pK(l) (Binding - Radioligand competition/displacement) 7-OH-DPAT Tschammer N et al (2011) Vass M et al (2019)
drd2_human 2.60x59 90 TM2 W => L 2.642↑ K(i) (Binding - Radioligand competition/displacement) clozapine Simpson MM et al (1999) Vass M et al (2019)
drd2_human 2.61x60 91 TM2 V => F 49.123↑ K(i) (Binding - Radioligand competition/displacement) clozapine Simpson MM et al (1999) Vass M et al (2019)
drd2_human 2.64x63 94 TM2 L => S 2.786↓ K(i) (Binding - Radioligand competition/displacement) clozapine Simpson MM et al (1999) Vass M et al (2019)
drd2_human 3.28x28 110 TM3 F => L 2.0↓ K(i) (Binding - Radioligand competition/displacement) clozapine Simpson MM et al (1999) Vass M et al (2019)
drd2_human 3.29x29 111 TM3 V => M 1.321↓ K(i) (Binding - Radioligand competition/displacement) clozapine Simpson MM et al (1999) Vass M et al (2019)
drd2_human 5.38x39 189 TM5 F => Y 5.49↑ K(i) (Binding - Radioligand competition/displacement) clozapine Simpson MM et al (1999) Vass M et al (2019)
drd2_human 5.45x46 196 TM5 V => C 1.321↓ K(i) (Binding - Radioligand competition/displacement) clozapine Simpson MM et al (1999) Vass M et al (2019)
drd2_human 311 ICL3 S => C 1.524↑ K(i) (Binding - Radioligand competition/displacement) clozapine Faron-Gorecka A et al (2008) Vass M et al (2019)
drd2_human 311 ICL3 S => C Abolished effect K(i) (Binding - Radioligand competition/displacement) clozapine Faron-Gorecka A et al (2008) Vass M et al (2019)
drd2_human 6.54x54 392 TM6 T => V 1.0 K(i) (Binding - Radioligand competition/displacement) clozapine Simpson MM et al (1999) Vass M et al (2019)
drd2_human 7.35x34 408 TM7 Y => V 4.667↑ K(i) (Binding - Radioligand competition/displacement) clozapine Simpson MM et al (1999) Vass M et al (2019)
drd2_human 7.38x37 411 TM7 F => V 1.4↑ K(i) (Binding - Radioligand competition/displacement) clozapine Simpson MM et al (1999) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => A 2.291↑ pK(0.5) (Binding - Radioligand competition/displacement) buspirone Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => F 11.482↑ pK(0.5) (Binding - Radioligand competition/displacement) buspirone Tschammer N et al (2011) Vass M et al (2019)
drd2_human 5.47x47 198 TM5 F => A 1.302↑ K(i) (Binding - Radioligand competition/displacement) bromocriptine Cho W et al (1995) Vass M et al (2019)
drd2_human 6.49x49 387 TM6 L => A 1.39↑ K(i) (Binding - Radioligand competition/displacement) bromocriptine Cho W et al (1995) Vass M et al (2019)
drd2_human 6.51x51 389 TM6 F => A 100.0↓ K(i) (Binding - Radioligand competition/displacement) bromocriptine Cho W et al (1995) Vass M et al (2019)
drd2_human 7.38x37 411 TM7 F => A 1.242↑ K(i) (Binding - Radioligand competition/displacement) bromocriptine Cho W et al (1995) Vass M et al (2019)
drd2_human 5.47x47 198 TM5 F => A 5.128↑ K(i) (Binding - Radioligand competition/displacement) apomorphine Cho W et al (1995) Vass M et al (2019)
drd2_human 6.49x49 387 TM6 L => A 1.1↓ K(i) (Binding - Radioligand competition/displacement) apomorphine Cho W et al (1995) Vass M et al (2019)
drd2_human 6.51x51 389 TM6 F => A 76.923↓ K(i) (Binding - Radioligand competition/displacement) apomorphine Cho W et al (1995) Vass M et al (2019)
drd2_human 7.38x37 411 TM7 F => A 1.25↓ K(i) (Binding - Radioligand competition/displacement) apomorphine Cho W et al (1995) Vass M et al (2019)
drd2_human 6.52x52 390 TM6 F => W 1.464↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Tschammer N et al (2010) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => A 1.549↑ pK(0.5) (Binding - Radioligand competition/displacement) haloperidol Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => F 1.122↑ pK(0.5) (Binding - Radioligand competition/displacement) haloperidol Tschammer N et al (2011) Vass M et al (2019)
drd2_human 2.61x60 91 TM2 V => A 13.889↓ pK(b) (Binding - Radioligand competition/displacement) dopamine Mistry SN et al (2015) Vass M et al (2019)
drd2_human 2.61x60 91 TM2 V => A 1.0 pK(b) (Binding - Radioligand competition/displacement) dopamine Mistry SN et al (2015) Vass M et al (2019)
drd2_human 2.65x64 95 TM2 E => A 1.23↑ pK(b) (Binding - Radioligand competition/displacement) dopamine Mistry SN et al (2015) Vass M et al (2019)
drd2_human 2.65x64 95 TM2 E => A 8.929↓ pK(b) (Binding - Radioligand competition/displacement) dopamine Mistry SN et al (2015) Vass M et al (2019)
drd2_human 2.65x64 95 TM2 E => A 107.152↑ pK(b) (Binding - Radioligand competition/displacement) dopamine Mistry SN et al (2015) Vass M et al (2019)
drd2_human 3.36x36 118 TM3 C => A No effect K(i) (Binding - Radioligand competition/displacement) dopamine Simpson MM et al (1999) Vass M et al (2019)
drd2_human 3.36x36 118 TM3 C => K ~10000.0↑ K(i) (Binding - Radioligand competition/displacement) dopamine Simpson MM et al (1999) Vass M et al (2019)
drd2_human 3.36x36 118 TM3 C => M No effect K(i) (Binding - Radioligand competition/displacement) dopamine Simpson MM et al (1999) Vass M et al (2019)
drd2_human 3.36x36 118 TM3 C => S No effect K(i) (Binding - Radioligand competition/displacement) dopamine Simpson MM et al (1999) Vass M et al (2019)
drd2_human 5.42x43 193 TM5 S => A 166.667↓ K(i) (Binding - Radioligand competition/displacement) dopamine Fowler JC et al (2012) Vass M et al (2019)
drd2_human 5.43x44 194 TM5 S => A 66.667↓ K(i) (Binding - Radioligand competition/displacement) dopamine Fowler JC et al (2012) Vass M et al (2019)
drd2_human 5.46x461 197 TM5 S => A 7.752↓ K(i) (Binding - Radioligand competition/displacement) dopamine Fowler JC et al (2012) Vass M et al (2019)
drd2_human 5.47x47 198 TM5 F => A 1.6↓ K(i) (Binding - Radioligand competition/displacement) dopamine Cho W et al (1995) Vass M et al (2019)
drd2_human 6.49x49 387 TM6 L => A 10.0↓ K(i) (Binding - Radioligand competition/displacement) dopamine Cho W et al (1995) Vass M et al (2019)
drd2_human 6.51x51 389 TM6 F => A 58.824↓ K(i) (Binding - Radioligand competition/displacement) dopamine Cho W et al (1995) Vass M et al (2019)
drd2_human 6.52x52 390 TM6 F => W >45.455↓ K(0.5) (Binding - Radioligand competition/displacement) dopamine Tschammer N et al (2010) Vass M et al (2019)
drd2_human 6.52x52 390 TM6 F => W >10.0↓ K(l) (Binding - Radioligand competition/displacement) dopamine Tschammer N et al (2010) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => A 12.821↓ pK(0.5) (Binding - Radioligand competition/displacement) dopamine Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => F 8.929↓ pK(0.5) (Binding - Radioligand competition/displacement) dopamine Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => A 27.778↓ pK(h) (Binding - Radioligand competition/displacement) dopamine Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => F 18.182↓ pK(h) (Binding - Radioligand competition/displacement) dopamine Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => A 15.152↓ pK(l) (Binding - Radioligand competition/displacement) dopamine Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => F 10.989↓ pK(l) (Binding - Radioligand competition/displacement) dopamine Tschammer N et al (2011) Vass M et al (2019)
drd2_human 7.38x37 411 TM7 F => A 1.124↑ K(i) (Binding - Radioligand competition/displacement) dopamine Cho W et al (1995) Vass M et al (2019)
drd2_human 2.64x63 94 TM2 L => A 5.229↑ K(d) (Binding - Radioligand kinetics (association/dissociation)) risperidone Wang S et al (2018) Vass M et al (2019)
drd2_human 23.50x50 100 ECL1 W => A 2.688↓ K(d) (Binding - Radioligand kinetics (association/dissociation)) risperidone Wang S et al (2018) Vass M et al (2019)
drd2_human 23.50x50 100 ECL1 W => F 2.11↓ K(d) (Binding - Radioligand kinetics (association/dissociation)) risperidone Wang S et al (2018) Vass M et al (2019)
drd2_human 23.50x50 100 ECL1 W => L 2.695↓ K(d) (Binding - Radioligand kinetics (association/dissociation)) risperidone Wang S et al (2018) Vass M et al (2019)
drd2_human 23.50x50 100 ECL1 W => A 1.808↓ K(i) (Binding - Radioligand competition/displacement) risperidone Wang S et al (2018) Vass M et al (2019)
drd2_human 3.28x28 110 TM3 F => A 8.197↓ K(i) (Binding - Radioligand competition/displacement) risperidone Wang S et al (2018) Vass M et al (2019)
drd2_human 3.32x32 114 TM3 D => A N/A K(i) (Binding - Radioligand competition/displacement) risperidone Wang S et al (2018) Vass M et al (2019)
drd2_human 3.33x33 115 TM3 V => A 1.466↑ K(i) (Binding - Radioligand competition/displacement) risperidone Wang S et al (2018) Vass M et al (2019)
drd2_human 3.36x36 118 TM3 C => A 1.075↓ K(i) (Binding - Radioligand competition/displacement) risperidone Wang S et al (2018) Vass M et al (2019)
drd2_human 3.37x37 119 TM3 T => A 40.0↓ K(i) (Binding - Radioligand competition/displacement) risperidone Wang S et al (2018) Vass M et al (2019)
drd2_human 3.40x40 122 TM3 I => A 3.086↓ K(i) (Binding - Radioligand competition/displacement) risperidone Wang S et al (2018) Vass M et al (2019)
drd2_human 45.52x52 184 ECL2 I => A 4.648↑ K(d) (Binding - Radioligand kinetics (association/dissociation)) risperidone Wang S et al (2018) Vass M et al (2019)
drd2_human 5.46x461 197 TM5 S => A 3.689↑ K(i) (Binding - Radioligand competition/displacement) risperidone Wang S et al (2018) Vass M et al (2019)
drd2_human 5.47x47 198 TM5 F => A 9.346↓ K(i) (Binding - Radioligand competition/displacement) risperidone Wang S et al (2018) Vass M et al (2019)
drd2_human 6.44x44 382 TM6 F => A 12.821↓ K(i) (Binding - Radioligand competition/displacement) risperidone Wang S et al (2018) Vass M et al (2019)
drd2_human 6.48x48 386 TM6 W => A N/A K(i) (Binding - Radioligand competition/displacement) risperidone Wang S et al (2018) Vass M et al (2019)
drd2_human 6.51x51 389 TM6 F => A 500.0↓ K(i) (Binding - Radioligand competition/displacement) risperidone Wang S et al (2018) Vass M et al (2019)
drd2_human 6.52x52 390 TM6 F => A 6.944↓ K(i) (Binding - Radioligand competition/displacement) risperidone Wang S et al (2018) Vass M et al (2019)
drd2_human 7.35x34 408 TM7 Y => A 3.03↓ K(i) (Binding - Radioligand competition/displacement) risperidone Wang S et al (2018) Vass M et al (2019)
drd2_human 7.39x38 412 TM7 T => A 22.727↓ K(i) (Binding - Radioligand competition/displacement) risperidone Wang S et al (2018) Vass M et al (2019)
drd2_human 7.43x42 416 TM7 Y => A 500.0↓ K(i) (Binding - Radioligand competition/displacement) risperidone Wang S et al (2018) Vass M et al (2019)
drd2_human 5.47x47 198 TM5 F => A 1.429↓ K(d) (Binding - Radioligand saturation) raclopride Cho W et al (1995) Vass M et al (2019)
drd2_human 6.49x49 387 TM6 L => A 2.45↑ K(d) (Binding - Radioligand saturation) raclopride Cho W et al (1995) Vass M et al (2019)
drd2_human 6.51x51 389 TM6 F => A Abolishment K(d) (Binding - Radioligand saturation) raclopride Cho W et al (1995) Vass M et al (2019)
drd2_human 6.52x52 390 TM6 F => A Abolishment K(d) (Binding - Radioligand saturation) raclopride Cho W et al (1995) Vass M et al (2019)
drd2_human 7.38x37 411 TM7 F => A 2.45↑ K(d) (Binding - Radioligand saturation) raclopride Cho W et al (1995) Vass M et al (2019)
drd2_human 5.42x43 193 TM5 S => A 32.258↓ K(i) (Binding - Radioligand competition/displacement) DNX Fowler JC et al (2012) Vass M et al (2019)
drd2_human 5.43x44 194 TM5 S => A 9.259↓ K(i) (Binding - Radioligand competition/displacement) DNX Fowler JC et al (2012) Vass M et al (2019)
drd2_human 5.46x461 197 TM5 S => A 6.993↓ K(i) (Binding - Radioligand competition/displacement) DNX Fowler JC et al (2012) Vass M et al (2019)
drd2_human 23.49x49 99 ECL1 E => V 2.512↑ pK(i) (Binding - Radioligand competition/displacement) NAPS Michino M et al (2013) Vass M et al (2019)
drd2_human 181 ECL2 E => V 2.291↑ pK(i) (Binding - Radioligand competition/displacement) NAPS Michino M et al (2013) Vass M et al (2019)
drd2_human 2.60x59 90 TM2 W => L 2.788↑ K(i) (Binding - Radioligand competition/displacement) L745870 Simpson MM et al (1999) Vass M et al (2019)
drd2_human 2.61x60 91 TM2 V => F 96.842↑ K(i) (Binding - Radioligand competition/displacement) L745870 Simpson MM et al (1999) Vass M et al (2019)
drd2_human 2.64x63 94 TM2 L => S 1.704↑ K(i) (Binding - Radioligand competition/displacement) L745870 Simpson MM et al (1999) Vass M et al (2019)
drd2_human 3.28x28 110 TM3 F => L 5.287↑ K(i) (Binding - Radioligand competition/displacement) L745870 Simpson MM et al (1999) Vass M et al (2019)
drd2_human 3.29x29 111 TM3 V => M 1.792↓ K(i) (Binding - Radioligand competition/displacement) L745870 Simpson MM et al (1999) Vass M et al (2019)
drd2_human 5.38x39 189 TM5 F => Y 2.706↑ K(i) (Binding - Radioligand competition/displacement) L745870 Simpson MM et al (1999) Vass M et al (2019)
drd2_human 5.45x46 196 TM5 V => C 1.673↑ K(i) (Binding - Radioligand competition/displacement) L745870 Simpson MM et al (1999) Vass M et al (2019)
drd2_human 6.54x54 392 TM6 T => V 1.227↑ K(i) (Binding - Radioligand competition/displacement) L745870 Simpson MM et al (1999) Vass M et al (2019)
drd2_human 7.35x34 408 TM7 Y => V 3.286↑ K(i) (Binding - Radioligand competition/displacement) L745870 Simpson MM et al (1999) Vass M et al (2019)
drd2_human 7.38x37 411 TM7 F => V 1.165↑ K(i) (Binding - Radioligand competition/displacement) L745870 Simpson MM et al (1999) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => A 14.454↑ pK(0.5) (Binding - Radioligand competition/displacement) FAUC346 Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => F 1.413↑ pK(0.5) (Binding - Radioligand competition/displacement) FAUC346 Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => A 37.154↑ pK(0.5) (Binding - Radioligand competition/displacement) CHEMBL112065 Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => F 3.472↓ pK(0.5) (Binding - Radioligand competition/displacement) CHEMBL112065 Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => A 4.786↑ pK(0.5) (Binding - Radioligand competition/displacement) CHEMBL140612 Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => F 2.688↓ pK(0.5) (Binding - Radioligand competition/displacement) CHEMBL140612 Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => A 3.162↑ pK(0.5) (Binding - Radioligand competition/displacement) CHEMBL561763 Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => F 1.35↓ pK(0.5) (Binding - Radioligand competition/displacement) CHEMBL561763 Tschammer N et al (2011) Vass M et al (2019)
drd2_human 23.49x49 99 ECL1 E => V 2.288↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL1627306 Michino M et al (2013) Vass M et al (2019)
drd2_human 181 ECL2 E => V 2.571↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL1627306 Michino M et al (2013) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => A 7.762↑ pK(0.5) (Binding - Radioligand competition/displacement) FAUC350 Tschammer N et al (2011) Vass M et al (2019)
drd2_human 6.55x55 393 TM6 H => F 1.95↑ pK(0.5) (Binding - Radioligand competition/displacement) FAUC350 Tschammer N et al (2011) Vass M et al (2019)
drd2_human 3.28x28 110 TM3 F => A 3.937↓ K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
drd2_human 3.32x32 114 TM3 D => A Abolished K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
drd2_human 5.47x47 198 TM5 F => A 1.799↓ K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
drd2_human 5.48x48 199 TM5 Y => A 6.289↓ K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
drd2_human 5.51x51 202 TM5 F => A 3.717↓ K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
drd2_human 6.44x44 382 TM6 F => A 1.305↑ K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
drd2_human 6.48x48 386 TM6 W => A Abolished K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
drd2_human 6.49x49 387 TM6 L => A 4.717↓ K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
drd2_human 6.51x51 389 TM6 F => A 3.077↓ K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
drd2_human 6.52x52 390 TM6 F => A 1.57↑ K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
drd2_human 7.39x38 412 TM7 T => A 1.604↑ K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
drd2_human 7.43x42 416 TM7 Y => A 9.174↓ K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
drd2_human 3.28x28 110 TM3 F => A 111.111↓ K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
drd2_human 3.32x32 114 TM3 D => A Abolished K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
drd2_human 5.47x47 198 TM5 F => A 2.959↓ K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
drd2_human 5.48x48 199 TM5 Y => A 8.13↓ K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
drd2_human 5.51x51 202 TM5 F => A 2.37↓ K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
drd2_human 6.44x44 382 TM6 F => A 2.632↓ K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
drd2_human 6.48x48 386 TM6 W => A 55.556↓ K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
drd2_human 6.49x49 387 TM6 L => A 5.128↓ K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
drd2_human 6.51x51 389 TM6 F => A 26.316↓ K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
drd2_human 6.52x52 390 TM6 F => A 10.101↓ K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
drd2_human 7.39x38 412 TM7 T => A 2.049↓ K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
drd2_human 7.43x42 416 TM7 Y => A 35.714↓ K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 K A L Q ICL1ECL1 E W K F ECL1ICL2 P M L Y N ICL2ECL2 L N N A D Q N E C I I A ECL2ICL3 R S S R A F R A H L R A P L K G N C T H P E D M K L C T V I M K S N G S F P V N R R R V E A A R R A Q E L E M E M L S S T S P P E R T R Y S P I P P S H H Q L T L P D P S H H G L H S T P D S P A K P E K N G H A K D H P K I A K I F E I Q T M P N G K T R T S L K T M S R R ICL3ECL3 D C N I ECL3N-term M D P L N L S W Y D D D L E R Q N W S R P F N G S D G K A D N-termC-term C C-term R P H Y N Y Y A T L L T L L I A V I V F G N V L V C M A V S R E T T T N Y L I V S L A V A D L L V A T L V M P W V V Y L E V V G S R I H C D I F V T L D V M M C T A S I L N L C A I S I D R Y T A V A M T R Y S S K R R V T V M I S I V W V L S F T I S C P L L F G N P A F V V Y S S I V S F Y V P F I V T L L V Y I K I Y I V L R R R R K R V N T K K L S Q Q K E K K A T Q M L A I V L G V F I I C W L P F F I T H I L N I H C P P V L Y S A F T W L G Y V N S A V N P I I Y T T F N I E F L K F R K A I L H
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
V N G F V I V A I L L T L L T A Y Y N Y 1 V S L A V A D L L V A L T V M P W V V Y L 2 A C L N L I S A T C M M V D L T V F I D 3 V T V M I S I V W V L S F T I S C P L 4 Y V L L T V I F P V Y F S V I S S Y V V F 5 A I V L G V F I I C W L P F F I T H I L 6 I P N V A S N V Y G L W T F A S Y L V 7
Download: PNG | SVG




Residue Table


GPCRdb(A)
GPCRdb(A)
D2 receptor
TM1
1x54 1.54x54 C56
TM2
2x47 2.47x47 A77
2x48 2.48x48 V78
2x49 2.49x49 A79
2x50 2.50x50 D80
2x51 2.51x51 L81
2x52 2.52x52 L82
2x53 2.53x53 V83
2x54 2.54x54 A84
2x55 2.55x55 T85
2x551 2.56x551 L86
2x56 2.57x56 V87
2x57 2.58x57 M88
2x58 2.59x58 P89
2x59 2.60x59 W90
2x60 2.61x60 V91
2x61 2.62x61 V92
2x62 2.63x62 Y93
2x63 2.64x63 L94
2x64 2.65x64 E95
2x65 2.66x65 V96
2x66 2.67x66 V97
2x67 2.68x67 G98
TM3
3x26 3.26x26 D108
3x27 3.27x27 I109
3x28 3.28x28 F110
3x29 3.29x29 V111
3x30 3.30x30 T112
3x31 3.31x31 L113
3x32 3.32x32 D114
3x33 3.33x33 V115
3x34 3.34x34 M116
3x35 3.35x35 M117
3x36 3.36x36 C118
3x37 3.37x37 T119
3x38 3.38x38 A120
3x39 3.39x39 S121
3x40 3.40x40 I122
3x41 3.41x41 L123
3x42 3.42x42 N124
3x43 3.43x43 L125
3x44 3.44x44 C126
3x45 3.45x45 A127
3x46 3.46x46 I128
3x47 3.47x47 S129
3x48 3.48x48 I130
TM4
4x39 4.39x39 K149
4x43 4.43x43 T153
4x44 4.44x44 V154
4x45 4.45x45 M155
4x57 4.57x57 S167
4x59 4.58x59 C168
4x63 4.62x63 F172
TM5
5x39 5.38x39 F189
5x43 5.42x43 S193
5x44 5.43x44 S194
5x46 5.45x46 V196
5x461 5.46x461 S197
5x47 5.47x47 F198
5x48 5.48x48 Y199
5x51 5.51x51 F202
TM6
6x33 6.33x33 A371
6x34 6.34x34 T372
6x35 6.35x35 Q373
6x39 6.39x39 I377
6x40 6.40x40 V378
6x41 6.41x41 L379
6x42 6.42x42 G380
6x43 6.43x43 V381
6x44 6.44x44 F382
6x45 6.45x45 I383
6x46 6.46x46 I384
6x47 6.47x47 C385
6x48 6.48x48 W386
6x49 6.49x49 L387
6x50 6.50x50 P388
6x51 6.51x51 F389
6x52 6.52x52 F390
6x53 6.53x53 I391
6x54 6.54x54 T392
6x55 6.55x55 H393
6x56 6.56x56 I394
6x57 6.57x57 L395
6x58 6.58x58 N396
6x59 6.59x59 I397
6x60 6.60x60 H398
TM7
7x34 7.35x34 Y408
7x37 7.38x37 F411
7x38 7.39x38 T412
7x42 7.43x42 Y416