Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
AssayType |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 93149 | 216841 | 57 | None | -1 | 3 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1ccnc2c1ccc1cccnc12 | 10.1021/jm301121j | ||
| CHEMBL316589 | 216841 | 57 | None | -1 | 3 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1ccnc2c1ccc1cccnc12 | 10.1021/jm301121j | ||
| 336912 | 174771 | 18 | None | None | None | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 240 | 2 | 2 | 4 | 1.8 | OCc1ccc2ccc3ccc(CO)nc3c2n1 | 10.1021/jm301121j | ||
| CHEMBL2205802 | 174771 | 18 | None | None | None | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 240 | 2 | 2 | 4 | 1.8 | OCc1ccc2ccc3ccc(CO)nc3c2n1 | 10.1021/jm301121j | ||
| 2733927 | 174776 | 61 | None | -1 | 3 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 216 | 3 | 0 | 4 | 2.2 | COc1ccnc(-c2cc(OC)ccn2)c1 | 10.1021/jm301121j | ||
| CHEMBL2205808 | 174776 | 61 | None | -1 | 3 | Human | 5.0 | pEC50 | = | 5 | Functional | ChEMBL | 216 | 3 | 0 | 4 | 2.2 | COc1ccnc(-c2cc(OC)ccn2)c1 | 10.1021/jm301121j | ||
| 667748 | 174773 | 59 | None | -3 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 267 | 2 | 0 | 3 | 3.9 | Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 | 10.1021/jm301121j | ||
| CHEMBL2205805 | 174773 | 59 | None | -3 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 267 | 2 | 0 | 3 | 3.9 | Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 | 10.1021/jm301121j | ||
| 20445 | 174774 | 65 | None | -2 | 2 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1cccc(-c2cccc(C)n2)n1 | 10.1021/jm301121j | ||
| CHEMBL2205806 | 174774 | 65 | None | -2 | 2 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1cccc(-c2cccc(C)n2)n1 | 10.1021/jm301121j | ||
| 667748 | 174773 | 59 | None | -3 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 267 | 2 | 0 | 3 | 3.9 | Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 | 10.1021/jm301121j | ||
| CHEMBL2205805 | 174773 | 59 | None | -3 | 2 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 267 | 2 | 0 | 3 | 3.9 | Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 | 10.1021/jm301121j | ||
| 15783796 | 174779 | 3 | None | -1 | 3 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1cnc2c(ccc3cccnc32)c1 | 10.1021/jm301121j | ||
| CHEMBL2205810 | 174779 | 3 | None | -1 | 3 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1cnc2c(ccc3cccnc32)c1 | 10.1021/jm301121j | ||
| 602123 | 174772 | 48 | None | None | None | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 236 | 2 | 0 | 4 | 2.4 | O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 | 10.1021/jm301121j | ||
| CHEMBL2205803 | 174772 | 48 | None | None | None | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 236 | 2 | 0 | 4 | 2.4 | O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 | 10.1021/jm301121j | ||
| 20445 | 174774 | 65 | None | -2 | 2 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1cccc(-c2cccc(C)n2)n1 | 10.1021/jm301121j | ||
| CHEMBL2205806 | 174774 | 65 | None | -2 | 2 | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1cccc(-c2cccc(C)n2)n1 | 10.1021/jm301121j | ||
| 15783796 | 174779 | 3 | None | -1 | 3 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1cnc2c(ccc3cccnc32)c1 | 10.1021/jm301121j | ||
| CHEMBL2205810 | 174779 | 3 | None | -1 | 3 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1cnc2c(ccc3cccnc32)c1 | 10.1021/jm301121j | ||
| 602123 | 174772 | 48 | None | None | None | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 236 | 2 | 0 | 4 | 2.4 | O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 | 10.1021/jm301121j | ||
| CHEMBL2205803 | 174772 | 48 | None | None | None | Human | 4.9 | pEC50 | = | 4.9 | Functional | ChEMBL | 236 | 2 | 0 | 4 | 2.4 | O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 | 10.1021/jm301121j | ||
| 74265 | 475171 | 73 | None | -3 | 3 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 236 | 0 | 0 | 2 | 4.0 | Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C | 10.1021/jm301121j | ||
| CHEMBL99384 | 475171 | 73 | None | -3 | 3 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 236 | 0 | 0 | 2 | 4.0 | Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C | 10.1021/jm301121j | ||
| 353741 | 144287 | 4 | None | None | None | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 364 | 2 | 0 | 2 | 4.6 | BrCc1ccc2ccc3ccc(CBr)nc3c2n1 | 10.1021/jm301121j | ||
| CHEMBL1976682 | 144287 | 4 | None | None | None | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 364 | 2 | 0 | 2 | 4.6 | BrCc1ccc2ccc3ccc(CBr)nc3c2n1 | 10.1021/jm301121j | ||
| 65237 | 275021 | 69 | None | 40 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccc2ccc3ccc(C)nc3c2n1 | 10.1021/jm301121j | ||
| CHEMBL375781 | 275021 | 69 | None | 40 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccc2ccc3ccc(C)nc3c2n1 | 10.1021/jm301121j | ||
| 74265 | 475171 | 73 | None | -3 | 3 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 236 | 0 | 0 | 2 | 4.0 | Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C | 10.1021/jm301121j | ||
| CHEMBL99384 | 475171 | 73 | None | -3 | 3 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 236 | 0 | 0 | 2 | 4.0 | Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C | 10.1021/jm301121j | ||
| 353741 | 144287 | 4 | None | None | None | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 364 | 2 | 0 | 2 | 4.6 | BrCc1ccc2ccc3ccc(CBr)nc3c2n1 | 10.1021/jm301121j | ||
| CHEMBL1976682 | 144287 | 4 | None | None | None | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 364 | 2 | 0 | 2 | 4.6 | BrCc1ccc2ccc3ccc(CBr)nc3c2n1 | 10.1021/jm301121j | ||
| 15664 | 174775 | 66 | None | -3 | 3 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | 10.1021/jm301121j | ||
| 5403 | 174775 | 66 | None | -3 | 3 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | 10.1021/jm301121j | ||
| CHEMBL2205807 | 174775 | 66 | None | -3 | 3 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | 10.1021/jm301121j | ||
| DB11932 | 174775 | 66 | None | -3 | 3 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | 10.1021/jm301121j | ||
| 65237 | 275021 | 69 | None | 40 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccc2ccc3ccc(C)nc3c2n1 | 10.1021/jm301121j | ||
| CHEMBL375781 | 275021 | 69 | None | 40 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccc2ccc3ccc(C)nc3c2n1 | 10.1021/jm301121j | ||
| 15664 | 174775 | 66 | None | -3 | 3 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | 10.1021/jm301121j | ||
| 5403 | 174775 | 66 | None | -3 | 3 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | 10.1021/jm301121j | ||
| CHEMBL2205807 | 174775 | 66 | None | -3 | 3 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | 10.1021/jm301121j | ||
| DB11932 | 174775 | 66 | None | -3 | 3 | Human | 4.8 | pEC50 | = | 4.8 | Functional | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | 10.1021/jm301121j | ||
| 72791 | 475073 | 52 | None | 1 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1cc2cccnc2c2ncccc12 | 10.1021/jm301121j | ||
| CHEMBL98682 | 475073 | 52 | None | 1 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1cc2cccnc2c2ncccc12 | 10.1021/jm301121j | ||
| 77865 | 216919 | 57 | None | 1 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 214 | 0 | 0 | 2 | 3.4 | Clc1cc2cccnc2c2ncccc12 | 10.1021/jm301121j | ||
| CHEMBL317115 | 216919 | 57 | None | 1 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 214 | 0 | 0 | 2 | 3.4 | Clc1cc2cccnc2c2ncccc12 | 10.1021/jm301121j | ||
| 72791 | 475073 | 52 | None | 1 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1cc2cccnc2c2ncccc12 | 10.1021/jm301121j | ||
| CHEMBL98682 | 475073 | 52 | None | 1 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 194 | 0 | 0 | 2 | 3.1 | Cc1cc2cccnc2c2ncccc12 | 10.1021/jm301121j | ||
| 12041800 | 468506 | 1 | None | None | None | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 410 | 7 | 2 | 4 | 6.4 | Clc1ccc2c(NCCCCNc3ccnc4cc(Cl)ccc34)ccnc2c1 | 10.1016/j.bmcl.2011.11.014 | ||
| CHEMBL66165 | 468506 | 1 | None | None | None | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 410 | 7 | 2 | 4 | 6.4 | Clc1ccc2c(NCCCCNc3ccnc4cc(Cl)ccc34)ccnc2c1 | 10.1016/j.bmcl.2011.11.014 | ||
| 77865 | 216919 | 57 | None | 1 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 214 | 0 | 0 | 2 | 3.4 | Clc1cc2cccnc2c2ncccc12 | 10.1021/jm301121j | ||
| CHEMBL317115 | 216919 | 57 | None | 1 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 214 | 0 | 0 | 2 | 3.4 | Clc1cc2cccnc2c2ncccc12 | 10.1021/jm301121j | ||
| 1474 | 310449 | 80 | None | -1 | 3 | Human | 4.5 | pEC50 | = | 4.5 | Functional | ChEMBL | 156 | 1 | 0 | 2 | 2.1 | c1ccc(-c2ccccn2)nc1 | 10.1021/jm301121j | ||
| 46936282 | 310449 | 80 | None | -1 | 3 | Human | 4.5 | pEC50 | = | 4.5 | Functional | ChEMBL | 156 | 1 | 0 | 2 | 2.1 | c1ccc(-c2ccccn2)nc1 | 10.1021/jm301121j | ||
| CHEMBL39879 | 310449 | 80 | None | -1 | 3 | Human | 4.5 | pEC50 | = | 4.5 | Functional | ChEMBL | 156 | 1 | 0 | 2 | 2.1 | c1ccc(-c2ccccn2)nc1 | 10.1021/jm301121j | ||
| DB03871 | 310449 | 80 | None | -1 | 3 | Human | 4.5 | pEC50 | = | 4.5 | Functional | ChEMBL | 156 | 1 | 0 | 2 | 2.1 | c1ccc(-c2ccccn2)nc1 | 10.1021/jm301121j | ||
| 1474 | 310449 | 80 | None | -1 | 3 | Human | 4.5 | pEC50 | = | 4.5 | Functional | ChEMBL | 156 | 1 | 0 | 2 | 2.1 | c1ccc(-c2ccccn2)nc1 | 10.1021/jm301121j | ||
| 46936282 | 310449 | 80 | None | -1 | 3 | Human | 4.5 | pEC50 | = | 4.5 | Functional | ChEMBL | 156 | 1 | 0 | 2 | 2.1 | c1ccc(-c2ccccn2)nc1 | 10.1021/jm301121j | ||
| CHEMBL39879 | 310449 | 80 | None | -1 | 3 | Human | 4.5 | pEC50 | = | 4.5 | Functional | ChEMBL | 156 | 1 | 0 | 2 | 2.1 | c1ccc(-c2ccccn2)nc1 | 10.1021/jm301121j | ||
| DB03871 | 310449 | 80 | None | -1 | 3 | Human | 4.5 | pEC50 | = | 4.5 | Functional | ChEMBL | 156 | 1 | 0 | 2 | 2.1 | c1ccc(-c2ccccn2)nc1 | 10.1021/jm301121j | ||
| 14338 | 18716 | 77 | None | -1 | 3 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccnc(-c2cc(C)ccn2)c1 | 10.1021/jm301121j | ||
| CHEMBL101165 | 18716 | 77 | None | -1 | 3 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccnc(-c2cc(C)ccn2)c1 | 10.1021/jm301121j | ||
| 14338 | 18716 | 77 | None | -1 | 3 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccnc(-c2cc(C)ccn2)c1 | 10.1021/jm301121j | ||
| CHEMBL101165 | 18716 | 77 | None | -1 | 3 | Human | 5.4 | pEC50 | = | 5.4 | Functional | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccnc(-c2cc(C)ccn2)c1 | 10.1021/jm301121j | ||
| 12987698 | 174777 | 3 | None | -2 | 3 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1cnc2c(ccc3cc(C)cnc32)c1 | 10.1021/jm301121j | ||
| CHEMBL2205809 | 174777 | 3 | None | -2 | 3 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1cnc2c(ccc3cc(C)cnc32)c1 | 10.1021/jm301121j | ||
| 14434082 | 174770 | 20 | None | 1 | 3 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 236 | 2 | 0 | 4 | 2.4 | O=Cc1ccnc2c1ccc1c(C=O)ccnc12 | 10.1021/jm301121j | ||
| CHEMBL2205801 | 174770 | 20 | None | 1 | 3 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 236 | 2 | 0 | 4 | 2.4 | O=Cc1ccnc2c1ccc1c(C=O)ccnc12 | 10.1021/jm301121j | ||
| 14434082 | 174770 | 20 | None | 1 | 3 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 236 | 2 | 0 | 4 | 2.4 | O=Cc1ccnc2c1ccc1c(C=O)ccnc12 | 10.1021/jm301121j | ||
| CHEMBL2205801 | 174770 | 20 | None | 1 | 3 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 236 | 2 | 0 | 4 | 2.4 | O=Cc1ccnc2c1ccc1c(C=O)ccnc12 | 10.1021/jm301121j | ||
| 12987698 | 174777 | 3 | None | -2 | 3 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1cnc2c(ccc3cc(C)cnc32)c1 | 10.1021/jm301121j | ||
| CHEMBL2205809 | 174777 | 3 | None | -2 | 3 | Human | 5.3 | pEC50 | = | 5.3 | Functional | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1cnc2c(ccc3cc(C)cnc32)c1 | 10.1021/jm301121j | ||
| 12425 | 11 | 80 | None | -1 | 3 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | ||
| 1318 | 11 | 80 | None | -1 | 3 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | ||
| CHEMBL415879 | 11 | 80 | None | -1 | 3 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | ||
| DB02365 | 11 | 80 | None | -1 | 3 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | ||
| 12425 | 11 | 80 | None | -1 | 3 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | ||
| 1318 | 11 | 80 | None | -1 | 3 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | ||
| CHEMBL415879 | 11 | 80 | None | -1 | 3 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | ||
| DB02365 | 11 | 80 | None | -1 | 3 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | ||
| 124734 | 473621 | 72 | None | -12 | 3 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 233 | 2 | 0 | 3 | 3.2 | c1ccc(-c2cccc(-c3ccccn3)n2)nc1 | 10.1021/jm301121j | ||
| 70848 | 473621 | 72 | None | -12 | 3 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 233 | 2 | 0 | 3 | 3.2 | c1ccc(-c2cccc(-c3ccccn3)n2)nc1 | 10.1021/jm301121j | ||
| CHEMBL89445 | 473621 | 72 | None | -12 | 3 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 233 | 2 | 0 | 3 | 3.2 | c1ccc(-c2cccc(-c3ccccn3)n2)nc1 | 10.1021/jm301121j | ||
| DB01912 | 473621 | 72 | None | -12 | 3 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 233 | 2 | 0 | 3 | 3.2 | c1ccc(-c2cccc(-c3ccccn3)n2)nc1 | 10.1021/jm301121j | ||
| 124734 | 473621 | 72 | None | -12 | 3 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 233 | 2 | 0 | 3 | 3.2 | c1ccc(-c2cccc(-c3ccccn3)n2)nc1 | 10.1021/jm301121j | ||
| 70848 | 473621 | 72 | None | -12 | 3 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 233 | 2 | 0 | 3 | 3.2 | c1ccc(-c2cccc(-c3ccccn3)n2)nc1 | 10.1021/jm301121j | ||
| CHEMBL89445 | 473621 | 72 | None | -12 | 3 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 233 | 2 | 0 | 3 | 3.2 | c1ccc(-c2cccc(-c3ccccn3)n2)nc1 | 10.1021/jm301121j | ||
| DB01912 | 473621 | 72 | None | -12 | 3 | Human | 4.2 | pEC50 | = | 4.2 | Functional | ChEMBL | 233 | 2 | 0 | 3 | 3.2 | c1ccc(-c2cccc(-c3ccccn3)n2)nc1 | 10.1021/jm301121j | ||
| 72792 | 433102 | 57 | None | -1 | 3 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccnc2c1ccc1c(C)ccnc12 | 10.1021/jm301121j | ||
| CHEMBL593442 | 433102 | 57 | None | -1 | 3 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccnc2c1ccc1c(C)ccnc12 | 10.1021/jm301121j | ||
| DB02586 | 433102 | 57 | None | -1 | 3 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccnc2c1ccc1c(C)ccnc12 | 10.1021/jm301121j | ||
| 72792 | 433102 | 57 | None | -1 | 3 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccnc2c1ccc1c(C)ccnc12 | 10.1021/jm301121j | ||
| CHEMBL593442 | 433102 | 57 | None | -1 | 3 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccnc2c1ccc1c(C)ccnc12 | 10.1021/jm301121j | ||
| DB02586 | 433102 | 57 | None | -1 | 3 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccnc2c1ccc1c(C)ccnc12 | 10.1021/jm301121j | ||
| 11151928 | 352668 | 0 | None | 4 | 4 | Human | 9.8 | pED50 | = | 9.8 | Functional | ChEMBL | 338 | 11 | 2 | 2 | 4.3 | CCCCCCCCCCC(C)(C)C(=O)N[C@@H]1CCCCNC1=O | 10.1021/jm900133w | ||
| 11359715 | 352668 | 0 | None | 4 | 4 | Human | 9.8 | pED50 | = | 9.8 | Functional | ChEMBL | 338 | 11 | 2 | 2 | 4.3 | CCCCCCCCCCC(C)(C)C(=O)N[C@@H]1CCCCNC1=O | 10.1021/jm900133w | ||
| CHEMBL468720 | 352668 | 0 | None | 4 | 4 | Human | 9.8 | pED50 | = | 9.8 | Functional | ChEMBL | 338 | 11 | 2 | 2 | 4.3 | CCCCCCCCCCC(C)(C)C(=O)N[C@@H]1CCCCNC1=O | 10.1021/jm900133w | ||
| CHEMBL513863 | 352668 | 0 | None | 4 | 4 | Human | 9.8 | pED50 | = | 9.8 | Functional | ChEMBL | 338 | 11 | 2 | 2 | 4.3 | CCCCCCCCCCC(C)(C)C(=O)N[C@@H]1CCCCNC1=O | 10.1021/jm900133w | ||
| 10456104 | 144205 | 0 | None | 56 | 2 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 443 | 5 | 1 | 3 | 4.6 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL197375 | 144205 | 0 | None | 56 | 2 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 443 | 5 | 1 | 3 | 4.6 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 59278332 | 335613 | 0 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 453 | 6 | 1 | 7 | 3.2 | CCC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4457209 | 335613 | 0 | None | None | None | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 453 | 6 | 1 | 7 | 3.2 | CCC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| 59278286 | 336088 | 1 | None | 112 | 2 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 453 | 6 | 1 | 7 | 3.2 | CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4464625 | 336088 | 1 | None | 112 | 2 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 453 | 6 | 1 | 7 | 3.2 | CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| 45138759 | 336858 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 467 | 7 | 1 | 7 | 3.6 | CCCC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4475581 | 336858 | 0 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 467 | 7 | 1 | 7 | 3.6 | CCCC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| 512282 | 1562 | 44 | None | 141 | 4 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.08.057 | ||
| 767 | 1562 | 44 | None | 141 | 4 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL232656 | 1562 | 44 | None | 141 | 4 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.08.057 | ||
| 6918497 | 232475 | 1 | None | -1 | 4 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | ||
| CHEMBL331897 | 232475 | 1 | None | -1 | 4 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | ||
| 66686405 | 346689 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 532 | 5 | 2 | 5 | 6.3 | CC(C)(O)c1ccc2c(c1)/C(=C\CCN1CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C1)c1cccnc1CO2 | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL4571977 | 346689 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 532 | 5 | 2 | 5 | 6.3 | CC(C)(O)c1ccc2c(c1)/C(=C\CCN1CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C1)c1cccnc1CO2 | 10.1016/j.bmcl.2018.11.015 | ||
| 9980155 | 144042 | 0 | None | 23 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 430 | 5 | 2 | 3 | 3.7 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL196860 | 144042 | 0 | None | 23 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 430 | 5 | 2 | 3 | 3.7 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O | 10.1016/j.bmcl.2005.08.057 | ||
| 10003548 | 144195 | 0 | None | 223 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 443 | 5 | 1 | 3 | 4.6 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL197345 | 144195 | 0 | None | 223 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 443 | 5 | 1 | 3 | 4.6 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 11743399 | 144696 | 8 | None | 32 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 429 | 5 | 1 | 3 | 4.2 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL198949 | 144696 | 8 | None | 32 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 429 | 5 | 1 | 3 | 4.2 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 44405176 | 272843 | 0 | None | 1 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 471 | 6 | 1 | 4 | 4.3 | COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL372807 | 272843 | 0 | None | 1 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 471 | 6 | 1 | 4 | 4.3 | COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl | 10.1016/j.bmcl.2005.08.057 | ||
| 44309143 | 468504 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 481 | 11 | 4 | 6 | 2.9 | CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NN | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL66159 | 468504 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 481 | 11 | 4 | 6 | 2.9 | CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NN | 10.1016/j.bmcl.2004.02.022 | ||
| 59278147 | 347111 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 492 | 5 | 1 | 6 | 3.9 | CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4518015 | 347111 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 492 | 5 | 1 | 6 | 3.9 | CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc(C(F)(F)F)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| 512282 | 1562 | 44 | None | 141 | 4 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2018.11.015 | ||
| 767 | 1562 | 44 | None | 141 | 4 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL232656 | 1562 | 44 | None | 141 | 4 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2018.11.015 | ||
| 59278115 | 348867 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 439 | 5 | 1 | 7 | 2.8 | CC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4562738 | 348867 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 439 | 5 | 1 | 7 | 2.8 | CC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| 512282 | 1562 | 44 | None | 141 | 4 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1021/jm801416q | ||
| 767 | 1562 | 44 | None | 141 | 4 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1021/jm801416q | ||
| CHEMBL232656 | 1562 | 44 | None | 141 | 4 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1021/jm801416q | ||
| 10434371 | 145166 | 0 | None | 5 | 2 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 459 | 6 | 1 | 4 | 4.2 | COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL200629 | 145166 | 0 | None | 5 | 2 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 459 | 6 | 1 | 4 | 4.2 | COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl | 10.1016/j.bmcl.2005.08.057 | ||
| 52916803 | 335526 | 28 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 451 | 5 | 1 | 7 | 2.8 | CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4456123 | 335526 | 28 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 451 | 5 | 1 | 7 | 2.8 | CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 | 10.1016/j.bmcl.2018.12.024 | ||
| 155511620 | 334156 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 453 | 6 | 1 | 3 | 6.3 | CCC[C@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cccc(C(F)(F)F)c1F | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL4436061 | 334156 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 453 | 6 | 1 | 3 | 6.3 | CCC[C@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cccc(C(F)(F)F)c1F | 10.1016/j.bmcl.2018.11.015 | ||
| 11554849 | 145064 | 0 | None | 2 | 2 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 484 | 7 | 1 | 4 | 3.9 | CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL200242 | 145064 | 0 | None | 2 | 2 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 484 | 7 | 1 | 4 | 3.9 | CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 | 10.1016/j.bmcl.2005.08.057 | ||
| 44453265 | 195757 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 442 | 7 | 2 | 4 | 3.6 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL256821 | 195757 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 442 | 7 | 2 | 4 | 3.6 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44453400 | 195899 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 460 | 7 | 2 | 4 | 3.8 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1Cl | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL257509 | 195899 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 460 | 7 | 2 | 4 | 3.8 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1Cl | 10.1016/j.bmcl.2007.09.068 | ||
| 10003548 | 144195 | 0 | None | 223 | 2 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 443 | 5 | 1 | 3 | 4.6 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL197345 | 144195 | 0 | None | 223 | 2 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 443 | 5 | 1 | 3 | 4.6 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 10072252 | 144831 | 0 | None | -17 | 2 | Mouse | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 446 | 5 | 1 | 4 | 4.1 | CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL199412 | 144831 | 0 | None | -17 | 2 | Mouse | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 446 | 5 | 1 | 4 | 4.1 | CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 44405203 | 144699 | 0 | None | 31 | 2 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 443 | 4 | 1 | 4 | 4.5 | CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL198966 | 144699 | 0 | None | 31 | 2 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 443 | 4 | 1 | 4 | 4.5 | CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 | 10.1016/j.bmcl.2005.08.057 | ||
| 44405202 | 145203 | 0 | None | 17 | 2 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 442 | 4 | 2 | 3 | 4.3 | CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL200794 | 145203 | 0 | None | 17 | 2 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 442 | 4 | 2 | 3 | 4.3 | CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 | 10.1016/j.bmcl.2005.08.057 | ||
| 76322249 | 215859 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 880 | 16 | 6 | 6 | 11.0 | CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(O)c(C(=O)NCC(=O)O)c5)c5cc(Cl)c(O)c(C(=O)NCC(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C | 10.1016/s0960-894x(00)00601-6 | ||
| CHEMBL3137848 | 215859 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 880 | 16 | 6 | 6 | 11.0 | CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(O)c(C(=O)NCC(=O)O)c5)c5cc(Cl)c(O)c(C(=O)NCC(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C | 10.1016/s0960-894x(00)00601-6 | ||
| CHEMBL3138130 | 477896 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 1034 | 20 | 4 | 6 | 15.9 | CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C | 10.1016/s0960-894x(00)00601-6 | ||
| CHEMBL3138370 | 477896 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5 | Functional | ChEMBL | 1034 | 20 | 4 | 6 | 15.9 | CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C | 10.1016/s0960-894x(00)00601-6 | ||
| 44453225 | 196100 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 440 | 4 | 1 | 5 | 3.5 | O=S(=O)(c1cccs1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL258368 | 196100 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 440 | 4 | 1 | 5 | 3.5 | O=S(=O)(c1cccs1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 10003548 | 144195 | 0 | None | 223 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 443 | 5 | 1 | 3 | 4.6 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL197345 | 144195 | 0 | None | 223 | 2 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 443 | 5 | 1 | 3 | 4.6 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 10789018 | 78655 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 435 | 7 | 1 | 4 | 5.1 | N#Cc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1021/jm990316l | ||
| CHEMBL143499 | 78655 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 435 | 7 | 1 | 4 | 5.1 | N#Cc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1021/jm990316l | ||
| 44453503 | 195455 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 490 | 8 | 2 | 5 | 4.7 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1ccsc1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL255338 | 195455 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 490 | 8 | 2 | 5 | 4.7 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1ccsc1 | 10.1016/j.bmcl.2007.09.068 | ||
| 58138765 | 348466 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 413 | 4 | 1 | 3 | 5.1 | O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1cccc(F)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4552741 | 348466 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 413 | 4 | 1 | 3 | 5.1 | O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1cccc(F)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| 44309194 | 468546 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 464 | 11 | 4 | 6 | 2.4 | CC(C)(O)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL66457 | 468546 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 464 | 11 | 4 | 6 | 2.4 | CC(C)(O)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O | 10.1016/j.bmcl.2004.02.022 | ||
| 44430752 | 178860 | 0 | None | 147 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 599 | 11 | 2 | 9 | 2.7 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| CHEMBL234295 | 178860 | 0 | None | 147 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 599 | 11 | 2 | 9 | 2.7 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| 44430752 | 178860 | 0 | None | 147 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 599 | 11 | 2 | 9 | 2.7 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| CHEMBL234295 | 178860 | 0 | None | 147 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 599 | 11 | 2 | 9 | 2.7 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| 59278305 | 334593 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 424 | 5 | 1 | 6 | 2.9 | CS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4442765 | 334593 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 424 | 5 | 1 | 6 | 2.9 | CS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| 59278307 | 336084 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 453 | 5 | 1 | 7 | 3.0 | CC(C)(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4464575 | 336084 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 453 | 5 | 1 | 7 | 3.0 | CC(C)(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| 44470374 | 349853 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 507 | 6 | 1 | 6 | 3.0 | CN1CCN(S(=O)(=O)c2ccc(CNC(=O)c3cccc4c3cnn4-c3ccc(F)cc3)cc2)CC1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4586189 | 349853 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 507 | 6 | 1 | 6 | 3.0 | CN1CCN(S(=O)(=O)c2ccc(CNC(=O)c3cccc4c3cnn4-c3ccc(F)cc3)cc2)CC1 | 10.1016/j.bmcl.2018.12.024 | ||
| 44453162 | 195643 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 526 | 4 | 1 | 4 | 4.6 | CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Br | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL256272 | 195643 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 526 | 4 | 1 | 4 | 4.6 | CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Br | 10.1016/j.bmcl.2007.09.068 | ||
| 44453199 | 196031 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 422 | 7 | 2 | 4 | 3.3 | Cc1ccc(S(=O)(=O)NCCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL258064 | 196031 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 422 | 7 | 2 | 4 | 3.3 | Cc1ccc(S(=O)(=O)NCCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44469804 | 336545 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 424 | 5 | 1 | 6 | 2.9 | CS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cn1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4471579 | 336545 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 424 | 5 | 1 | 6 | 2.9 | CS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cn1 | 10.1016/j.bmcl.2018.12.024 | ||
| 44405203 | 144699 | 0 | None | 31 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 443 | 4 | 1 | 4 | 4.5 | CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL198966 | 144699 | 0 | None | 31 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 443 | 4 | 1 | 4 | 4.5 | CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 | 10.1016/j.bmcl.2005.08.057 | ||
| 44309407 | 203014 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 476 | 9 | 4 | 6 | 2.5 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1(O)CCCCC1 | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL306457 | 203014 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 476 | 9 | 4 | 6 | 2.5 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1(O)CCCCC1 | 10.1016/j.bmcl.2004.02.022 | ||
| 44468442 | 335102 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 413 | 4 | 1 | 3 | 5.1 | O=C(NCc1ccccc1C(F)(F)F)c1cccc2c1cnn2-c1ccc(F)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4450029 | 335102 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 413 | 4 | 1 | 3 | 5.1 | O=C(NCc1ccccc1C(F)(F)F)c1cccc2c1cnn2-c1ccc(F)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| 155530458 | 336072 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 409 | 5 | 2 | 4 | 4.0 | O=C(NCc1cccc(C(F)(F)F)c1)c1cnn(-c2ccc(Cl)cc2)c1CO | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL4464403 | 336072 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 409 | 5 | 2 | 4 | 4.0 | O=C(NCc1cccc(C(F)(F)F)c1)c1cnn(-c2ccc(Cl)cc2)c1CO | 10.1016/j.bmcl.2018.11.015 | ||
| 44468440 | 347455 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 346 | 4 | 1 | 4 | 3.5 | O=C(NCc1ccncc1)c1cccc2c1cnn2-c1ccc(F)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4527255 | 347455 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 346 | 4 | 1 | 4 | 3.5 | O=C(NCc1ccncc1)c1cccc2c1cnn2-c1ccc(F)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4647642 | 478360 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 475 | 4 | 1 | 5 | 3.0 | O=C([C@H]1C[C@H](O)CN1c1ccc(Cl)cc1)N1CC2COCC(C1)N2Cc1ccc(Cl)cc1 | 10.6019/CHEMBL4630906 | ||
| 44453357 | 197826 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 434 | 4 | 1 | 4 | 3.5 | O=S(=O)(c1ccccc1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL270419 | 197826 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 434 | 4 | 1 | 4 | 3.5 | O=S(=O)(c1ccccc1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44453525 | 197806 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 452 | 4 | 1 | 4 | 3.6 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL270358 | 197806 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 452 | 4 | 1 | 4 | 3.6 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44309161 | 468792 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 462 | 9 | 3 | 6 | 2.3 | NC(=O)[C@@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1 | 10.1016/j.bmcl.2004.02.022 | ||
| 44309166 | 468792 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 462 | 9 | 3 | 6 | 2.3 | NC(=O)[C@@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1 | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL68368 | 468792 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 462 | 9 | 3 | 6 | 2.3 | NC(=O)[C@@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1 | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL69876 | 468792 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 462 | 9 | 3 | 6 | 2.3 | NC(=O)[C@@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1 | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL3138123 | 477894 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 1028 | 22 | 6 | 8 | 13.2 | CSCC[C@H](NC(=O)c1cc(C(=CCC[C@H]2CC[C@@]3(C)C(CC[C@@H]4[C@@H]3CC[C@@]3(C)[C@H]4CC[C@@H]3C(C)CCCC(C)C)C2)c2cc(Cl)c(O)c(C(=O)N[C@@H](CCSC)C(=O)O)c2)cc(Cl)c1O)C(=O)O | 10.1016/s0960-894x(00)00601-6 | ||
| 44453638 | 327635 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 468 | 4 | 1 | 4 | 4.1 | O=S(=O)(c1ccccc1Cl)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL427834 | 327635 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 468 | 4 | 1 | 4 | 4.1 | O=S(=O)(c1ccccc1Cl)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44430746 | 177992 | 0 | None | 41 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 530 | 10 | 3 | 8 | 2.3 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| CHEMBL232638 | 177992 | 0 | None | 41 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 530 | 10 | 3 | 8 | 2.3 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| 155564974 | 349474 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 439 | 5 | 1 | 3 | 5.9 | CC[C@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cccc(C(F)(F)F)c1F | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL4577357 | 349474 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 439 | 5 | 1 | 3 | 5.9 | CC[C@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cccc(C(F)(F)F)c1F | 10.1016/j.bmcl.2018.11.015 | ||
| 10388824 | 270926 | 0 | None | 4 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 445 | 5 | 1 | 3 | 4.7 | CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL370596 | 270926 | 0 | None | 4 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 445 | 5 | 1 | 3 | 4.7 | CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 44309397 | 468791 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 466 | 11 | 3 | 5 | 3.4 | CC(C)(F)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL68366 | 468791 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 466 | 11 | 3 | 5 | 3.4 | CC(C)(F)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O | 10.1016/j.bmcl.2004.02.022 | ||
| 44453320 | 197794 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 468 | 4 | 1 | 4 | 4.1 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL270253 | 197794 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 468 | 4 | 1 | 4 | 4.1 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44453579 | 311536 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 482 | 4 | 1 | 4 | 4.5 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL404465 | 311536 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 482 | 4 | 1 | 4 | 4.5 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44309364 | 468890 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 494 | 12 | 3 | 5 | 4.0 | CCNC(=O)C(CCC(C)(C)F)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL69123 | 468890 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 494 | 12 | 3 | 5 | 4.0 | CCNC(=O)C(CCC(C)(C)F)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.022 | ||
| 44453615 | 195538 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 512 | 4 | 1 | 4 | 4.2 | O=S(=O)(c1ccccc1Br)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL255797 | 195538 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 512 | 4 | 1 | 4 | 4.2 | O=S(=O)(c1ccccc1Br)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44453402 | 195937 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)cc(Cl)c1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL257698 | 195937 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)cc(Cl)c1 | 10.1016/j.bmcl.2007.09.068 | ||
| 10456104 | 144205 | 0 | None | 56 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 443 | 5 | 1 | 3 | 4.6 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL197375 | 144205 | 0 | None | 56 | 2 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 443 | 5 | 1 | 3 | 4.6 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 44430723 | 177717 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 544 | 8 | 2 | 7 | 3.1 | CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| CHEMBL232253 | 177717 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 544 | 8 | 2 | 7 | 3.1 | CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| 44453614 | 308735 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 512 | 4 | 1 | 4 | 4.2 | O=S(=O)(c1ccccc1Br)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL402825 | 308735 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 512 | 4 | 1 | 4 | 4.2 | O=S(=O)(c1ccccc1Br)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | ||
| 24758044 | 164277 | 0 | None | 5 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | ||
| 57888953 | 164277 | 0 | None | 5 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | ||
| 71455572 | 164277 | 0 | None | 5 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | ||
| CHEMBL2180523 | 164277 | 0 | None | 5 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | ||
| CHEMBL2180528 | 164277 | 0 | None | 5 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | ||
| CHEMBL2180534 | 164277 | 0 | None | 5 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | ||
| 44480600 | 349086 | 1 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 446 | 7 | 1 | 6 | 3.9 | CCCC(NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cncc(S(C)(=O)=O)c1 | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL4568048 | 349086 | 1 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 446 | 7 | 1 | 6 | 3.9 | CCCC(NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cncc(S(C)(=O)=O)c1 | 10.1016/j.bmcl.2018.11.015 | ||
| 44405212 | 145177 | 0 | None | 1 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 458 | 5 | 1 | 4 | 4.2 | CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL200680 | 145177 | 0 | None | 1 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 458 | 5 | 1 | 4 | 4.2 | CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 | 10.1016/j.bmcl.2005.08.057 | ||
| 10001921 | 144665 | 0 | None | 3 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 415 | 5 | 1 | 3 | 3.8 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL198852 | 144665 | 0 | None | 3 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 415 | 5 | 1 | 3 | 3.8 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2005.08.057 | ||
| 512282 | 1562 | 44 | None | -141 | 4 | Mouse | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.08.057 | ||
| 767 | 1562 | 44 | None | -141 | 4 | Mouse | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL232656 | 1562 | 44 | None | -141 | 4 | Mouse | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.08.057 | ||
| 10388824 | 270926 | 0 | None | 4 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 445 | 5 | 1 | 3 | 4.7 | CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL370596 | 270926 | 0 | None | 4 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 445 | 5 | 1 | 3 | 4.7 | CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 49865900 | 40073 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 448 | 4 | 1 | 3 | 6.0 | O=C(Nc1ccc(C(F)(F)F)cc1)N1CCCC1c1nccn1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.07.082 | ||
| CHEMBL1224118 | 40073 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 448 | 4 | 1 | 3 | 6.0 | O=C(Nc1ccc(C(F)(F)F)cc1)N1CCCC1c1nccn1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.07.082 | ||
| 24782574 | 353253 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 453 | 4 | 1 | 2 | 5.3 | Cc1cc(C(F)(F)F)ccc1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1 | 10.1021/jm801416q | ||
| CHEMBL473734 | 353253 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 453 | 4 | 1 | 2 | 5.3 | Cc1cc(C(F)(F)F)ccc1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1 | 10.1021/jm801416q | ||
| 9980155 | 144042 | 0 | None | 23 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 430 | 5 | 2 | 3 | 3.7 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL196860 | 144042 | 0 | None | 23 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 430 | 5 | 2 | 3 | 3.7 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O | 10.1016/j.bmcl.2005.08.057 | ||
| 44405234 | 270765 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 443 | 5 | 1 | 3 | 4.6 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL370447 | 270765 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 443 | 5 | 1 | 3 | 4.6 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 10575889 | 67305 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 458 | 8 | 1 | 3 | 6.3 | N#CC(CCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | ||
| CHEMBL142199 | 67305 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 458 | 8 | 1 | 3 | 6.3 | N#CC(CCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | ||
| 44453084 | 195641 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 422 | 6 | 2 | 3 | 4.6 | O=C(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL256264 | 195641 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 422 | 6 | 2 | 3 | 4.6 | O=C(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44430713 | 177592 | 0 | None | 30 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 500 | 8 | 2 | 7 | 3.0 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| CHEMBL231829 | 177592 | 0 | None | 30 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 500 | 8 | 2 | 7 | 3.0 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| 58138868 | 335099 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 414 | 4 | 1 | 4 | 4.5 | O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(F)nc1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4449996 | 335099 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 414 | 4 | 1 | 4 | 4.5 | O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(F)nc1 | 10.1016/j.bmcl.2018.12.024 | ||
| 58138852 | 348131 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 452 | 7 | 2 | 5 | 3.4 | CCNS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4544186 | 348131 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 452 | 7 | 2 | 5 | 3.4 | CCNS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| 58138832 | 334441 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 403 | 5 | 1 | 5 | 3.9 | COC(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4440452 | 334441 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 403 | 5 | 1 | 5 | 3.9 | COC(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| 155544726 | 348970 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 403 | 5 | 1 | 5 | 3.2 | Cc1c(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cnn1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL4565390 | 348970 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 403 | 5 | 1 | 5 | 3.2 | Cc1c(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cnn1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2018.11.015 | ||
| 44405194 | 144059 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 427 | 5 | 1 | 3 | 3.9 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H]2C[C@@H]1CN2Cc1ccc(F)cc1 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL196908 | 144059 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 427 | 5 | 1 | 3 | 3.9 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H]2C[C@@H]1CN2Cc1ccc(F)cc1 | 10.1016/j.bmcl.2005.08.057 | ||
| 44405181 | 260685 | 0 | None | 51 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 432 | 6 | 2 | 4 | 3.6 | CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL370162 | 260685 | 0 | None | 51 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 432 | 6 | 2 | 4 | 3.6 | CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 512282 | 1562 | 44 | None | 141 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2007.03.104 | ||
| 767 | 1562 | 44 | None | 141 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2007.03.104 | ||
| CHEMBL232656 | 1562 | 44 | None | 141 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2007.03.104 | ||
| 512282 | 1562 | 44 | None | 141 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2007.03.104 | ||
| 767 | 1562 | 44 | None | 141 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2007.03.104 | ||
| CHEMBL232656 | 1562 | 44 | None | 141 | 4 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2007.03.104 | ||
| 44430713 | 177592 | 0 | None | 30 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 500 | 8 | 2 | 7 | 3.0 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| CHEMBL231829 | 177592 | 0 | None | 30 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 500 | 8 | 2 | 7 | 3.0 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| 44453467 | 196094 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 502 | 4 | 1 | 4 | 4.8 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL258359 | 196094 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 502 | 4 | 1 | 4 | 4.8 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44453363 | 197829 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 458 | 7 | 2 | 4 | 4.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL270433 | 197829 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 458 | 7 | 2 | 4 | 4.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2007.09.068 | ||
| 44453501 | 198109 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 512 | 4 | 1 | 4 | 4.2 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Br)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL271903 | 198109 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 512 | 4 | 1 | 4 | 4.2 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Br)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44453292 | 311437 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 448 | 4 | 1 | 4 | 3.8 | Cc1ccccc1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL404033 | 311437 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 448 | 4 | 1 | 4 | 3.8 | Cc1ccccc1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 58138893 | 349481 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 466 | 7 | 2 | 5 | 3.8 | CC(C)NS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4577460 | 349481 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 466 | 7 | 2 | 5 | 3.8 | CC(C)NS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| 11801020 | 26518 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 434 | 7 | 1 | 1 | 6.4 | C[N+]1(CCCC(c2ccccc2)c2ccccc2)CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm990316l | ||
| CHEMBL1184558 | 26518 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 434 | 7 | 1 | 1 | 6.4 | C[N+]1(CCCC(c2ccccc2)c2ccccc2)CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm990316l | ||
| 22725647 | 347783 | 0 | None | -52 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 347 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | ||
| CHEMBL4535696 | 347783 | 0 | None | -52 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 347 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | ||
| 44430745 | 279221 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 544 | 11 | 2 | 8 | 3.0 | COCCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| CHEMBL387822 | 279221 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 544 | 11 | 2 | 8 | 3.0 | COCCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| 45138458 | 336220 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 439 | 6 | 1 | 7 | 2.7 | CCS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4466500 | 336220 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 439 | 6 | 1 | 7 | 2.7 | CCS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1 | 10.1016/j.bmcl.2018.12.024 | ||
| 44453164 | 196096 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 492 | 8 | 2 | 5 | 3.9 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1OC(F)(F)F | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL258361 | 196096 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 492 | 8 | 2 | 5 | 3.9 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1OC(F)(F)F | 10.1016/j.bmcl.2007.09.068 | ||
| 10001921 | 144665 | 0 | None | 3 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 415 | 5 | 1 | 3 | 3.8 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL198852 | 144665 | 0 | None | 3 | 2 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 415 | 5 | 1 | 3 | 3.8 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2005.08.057 | ||
| 155533145 | 336351 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 409 | 4 | 1 | 2 | 6.3 | Cc1cc(-c2ccc(Cl)cc2)sc1C(=O)NCc1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL4468514 | 336351 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 409 | 4 | 1 | 2 | 6.3 | Cc1cc(-c2ccc(Cl)cc2)sc1C(=O)NCc1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2018.11.015 | ||
| 10766998 | 77515 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 476 | 7 | 1 | 4 | 5.5 | COc1ccc(C(C#N)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1Br | 10.1021/jm990316l | ||
| CHEMBL142468 | 77515 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 476 | 7 | 1 | 4 | 5.5 | COc1ccc(C(C#N)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1Br | 10.1021/jm990316l | ||
| 22725647 | 347783 | 0 | None | -52 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 347 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | ||
| CHEMBL4535696 | 347783 | 0 | None | -52 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 347 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | ||
| 10164 | 1805 | 30 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 451 | 4 | 1 | 8 | 2.2 | COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1[nH]c(=C2N=CC=N2)c2c1nccc2 | 10.1016/j.bmcl.2018.11.015 | ||
| 135565361 | 1805 | 30 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 451 | 4 | 1 | 8 | 2.2 | COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1[nH]c(=C2N=CC=N2)c2c1nccc2 | 10.1016/j.bmcl.2018.11.015 | ||
| 25016615 | 1805 | 30 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 451 | 4 | 1 | 8 | 2.2 | COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1[nH]c(=C2N=CC=N2)c2c1nccc2 | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL4444976 | 1805 | 30 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 451 | 4 | 1 | 8 | 2.2 | COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1[nH]c(=C2N=CC=N2)c2c1nccc2 | 10.1016/j.bmcl.2018.11.015 | ||
| DB12963 | 1805 | 30 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 451 | 4 | 1 | 8 | 2.2 | COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1[nH]c(=C2N=CC=N2)c2c1nccc2 | 10.1016/j.bmcl.2018.11.015 | ||
| 52917500 | 336792 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 465 | 5 | 1 | 7 | 3.2 | CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CCC2)ccn1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4474606 | 336792 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 465 | 5 | 1 | 7 | 3.2 | CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CCC2)ccn1 | 10.1016/j.bmcl.2018.12.024 | ||
| 59278436 | 336829 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 439 | 6 | 2 | 6 | 2.4 | CNS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4475173 | 336829 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 439 | 6 | 2 | 6 | 2.4 | CNS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| 10049340 | 202703 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 448 | 11 | 3 | 5 | 3.3 | CC(C)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL304358 | 202703 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 448 | 11 | 3 | 5 | 3.3 | CC(C)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O | 10.1016/j.bmcl.2004.02.022 | ||
| 512282 | 1562 | 44 | None | 141 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.08.057 | ||
| 767 | 1562 | 44 | None | 141 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL232656 | 1562 | 44 | None | 141 | 4 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.08.057 | ||
| 44405181 | 260685 | 0 | None | 51 | 2 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 432 | 6 | 2 | 4 | 3.6 | CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL370162 | 260685 | 0 | None | 51 | 2 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 432 | 6 | 2 | 4 | 3.6 | CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 49865951 | 40089 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 463 | 4 | 1 | 4 | 5.7 | Cc1nnc([C@H]2CCCN2C(=O)Nc2ccc(C(F)(F)F)cc2)n1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.07.082 | ||
| CHEMBL1224189 | 40089 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 463 | 4 | 1 | 4 | 5.7 | Cc1nnc([C@H]2CCCN2C(=O)Nc2ccc(C(F)(F)F)cc2)n1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.07.082 | ||
| 10072252 | 144831 | 0 | None | 17 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 446 | 5 | 1 | 4 | 4.1 | CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL199412 | 144831 | 0 | None | 17 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 446 | 5 | 1 | 4 | 4.1 | CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 10434371 | 145166 | 0 | None | 5 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 459 | 6 | 1 | 4 | 4.2 | COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL200629 | 145166 | 0 | None | 5 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 459 | 6 | 1 | 4 | 4.2 | COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl | 10.1016/j.bmcl.2005.08.057 | ||
| 11719164 | 277557 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 441 | 5 | 1 | 3 | 4.3 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL380568 | 277557 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 441 | 5 | 1 | 3 | 4.3 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 | 10.1016/j.bmcl.2005.08.057 | ||
| 44453637 | 198288 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 468 | 4 | 1 | 4 | 4.1 | O=S(=O)(c1ccccc1Cl)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL272758 | 198288 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 468 | 4 | 1 | 4 | 4.1 | O=S(=O)(c1ccccc1Cl)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | ||
| 6918497 | 232475 | 1 | None | -17 | 4 | Mouse | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | ||
| CHEMBL331897 | 232475 | 1 | None | -17 | 4 | Mouse | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | ||
| 44453229 | 195770 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 426 | 7 | 2 | 4 | 3.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL256889 | 195770 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 426 | 7 | 2 | 4 | 3.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmcl.2007.09.068 | ||
| 58138845 | 350091 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 429 | 4 | 1 | 3 | 5.6 | O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4591935 | 350091 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 429 | 4 | 1 | 3 | 5.6 | O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| 155562877 | 349241 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 403 | 5 | 1 | 5 | 3.2 | Cc1c(C(=O)NCc2cccc(S(C)(=O)=O)c2)cnn1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL4571547 | 349241 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 403 | 5 | 1 | 5 | 3.2 | Cc1c(C(=O)NCc2cccc(S(C)(=O)=O)c2)cnn1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2018.11.015 | ||
| 25254218 | 40075 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 449 | 4 | 1 | 4 | 5.4 | O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1ncnn1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.07.082 | ||
| CHEMBL1224120 | 40075 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 449 | 4 | 1 | 4 | 5.4 | O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1ncnn1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.07.082 | ||
| 24782826 | 372710 | 4 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 439 | 4 | 1 | 2 | 5.0 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2010.07.082 | ||
| CHEMBL514611 | 372710 | 4 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 439 | 4 | 1 | 2 | 5.0 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2010.07.082 | ||
| 25233755 | 353230 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 457 | 4 | 1 | 2 | 5.2 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1F | 10.1021/jm801416q | ||
| CHEMBL473532 | 353230 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 457 | 4 | 1 | 2 | 5.2 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1F | 10.1021/jm801416q | ||
| 24782826 | 372710 | 4 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 439 | 4 | 1 | 2 | 5.0 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 | 10.1021/jm801416q | ||
| CHEMBL514611 | 372710 | 4 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 439 | 4 | 1 | 2 | 5.0 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 | 10.1021/jm801416q | ||
| 58138826 | 334956 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 413 | 4 | 1 | 3 | 5.1 | O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(F)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4448064 | 334956 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 413 | 4 | 1 | 3 | 5.1 | O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(F)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| 44309195 | 202240 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 496 | 9 | 3 | 5 | 3.6 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCC(F)(F)CC1 | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL302533 | 202240 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 496 | 9 | 3 | 5 | 3.6 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCC(F)(F)CC1 | 10.1016/j.bmcl.2004.02.022 | ||
| 44453167 | 196098 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 476 | 7 | 2 | 4 | 4.0 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL258363 | 196098 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 476 | 7 | 2 | 4 | 4.0 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44453195 | 311166 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 496 | 4 | 1 | 4 | 4.8 | Cc1cccc(Cl)c1S(=O)(=O)N1CCC(C)(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL402327 | 311166 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 496 | 4 | 1 | 4 | 4.8 | Cc1cccc(Cl)c1S(=O)(=O)N1CCC(C)(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44453197 | 311380 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 482 | 4 | 1 | 4 | 4.5 | CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2ccccc2Cl)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL403665 | 311380 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 482 | 4 | 1 | 4 | 4.5 | CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2ccccc2Cl)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44430748 | 178095 | 0 | None | 72 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 529 | 10 | 3 | 8 | 2.3 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| CHEMBL232837 | 178095 | 0 | None | 72 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 529 | 10 | 3 | 8 | 2.3 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| 44453504 | 195893 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 490 | 8 | 2 | 5 | 4.7 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1cccs1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL257452 | 195893 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 490 | 8 | 2 | 5 | 4.7 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1cccs1 | 10.1016/j.bmcl.2007.09.068 | ||
| 10003548 | 144195 | 0 | None | -223 | 2 | Mouse | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 443 | 5 | 1 | 3 | 4.6 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL197345 | 144195 | 0 | None | -223 | 2 | Mouse | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 443 | 5 | 1 | 3 | 4.6 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 52916803 | 335526 | 28 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 451 | 5 | 1 | 7 | 2.8 | CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 | 10.6019/CHEMBL5209897 | ||
| CHEMBL4456123 | 335526 | 28 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 451 | 5 | 1 | 7 | 2.8 | CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 | 10.6019/CHEMBL5209897 | ||
| 46858281 | 335946 | 2 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 394 | 4 | 1 | 4 | 4.2 | Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)nnn1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL4462565 | 335946 | 2 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 394 | 4 | 1 | 4 | 4.2 | Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)nnn1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2018.11.015 | ||
| 44453433 | 316434 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL411476 | 316434 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44430723 | 177717 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 544 | 8 | 2 | 7 | 3.1 | CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| CHEMBL232253 | 177717 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 544 | 8 | 2 | 7 | 3.1 | CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| 44469380 | 334803 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 413 | 4 | 1 | 3 | 5.1 | O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccccc1F | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4445779 | 334803 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 413 | 4 | 1 | 3 | 5.1 | O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccccc1F | 10.1016/j.bmcl.2018.12.024 | ||
| 9889700 | 237386 | 15 | None | 11 | 4 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 444 | 7 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | ||
| CHEMBL34166 | 237386 | 15 | None | 11 | 4 | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 444 | 7 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | ||
| 44453464 | 195673 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 488 | 4 | 1 | 4 | 3.9 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3cc(F)c(F)c(F)c3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL256449 | 195673 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Functional | ChEMBL | 488 | 4 | 1 | 4 | 3.9 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3cc(F)c(F)c(F)c3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 58138911 | 348658 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 463 | 4 | 1 | 3 | 6.3 | O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4557554 | 348658 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 463 | 4 | 1 | 3 | 6.3 | O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| 76336764 | 215866 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 766 | 12 | 4 | 4 | 12.8 | CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(O)c(C(=O)O)c5)c5cc(Cl)c(O)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C | 10.1016/s0960-894x(00)00601-6 | ||
| CHEMBL3138187 | 215866 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 766 | 12 | 4 | 4 | 12.8 | CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(O)c(C(=O)O)c5)c5cc(Cl)c(O)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C | 10.1016/s0960-894x(00)00601-6 | ||
| CHEMBL3138134 | 477897 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 1034 | 20 | 4 | 6 | 15.9 | CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6ccccc6C(=O)O)c(C(=O)O)c5)c5cc(Cl)c(OCc6ccccc6C(=O)O)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C | 10.1016/s0960-894x(00)00601-6 | ||
| CHEMBL3138376 | 477897 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 1034 | 20 | 4 | 6 | 15.9 | CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6ccccc6C(=O)O)c(C(=O)O)c5)c5cc(Cl)c(OCc6ccccc6C(=O)O)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C | 10.1016/s0960-894x(00)00601-6 | ||
| 44453157 | 311251 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 482 | 4 | 1 | 4 | 4.4 | Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL402827 | 311251 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 482 | 4 | 1 | 4 | 4.4 | Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | ||
| 155538947 | 346912 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 425 | 4 | 1 | 3 | 5.5 | Cc1c(C(=O)N[C@@H](C)c2cccc(C(F)(F)F)c2F)cnn1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL4513370 | 346912 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 425 | 4 | 1 | 3 | 5.5 | Cc1c(C(=O)N[C@@H](C)c2cccc(C(F)(F)F)c2F)cnn1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2018.11.015 | ||
| 44405203 | 144699 | 0 | None | 31 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 443 | 4 | 1 | 4 | 4.5 | CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL198966 | 144699 | 0 | None | 31 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 443 | 4 | 1 | 4 | 4.5 | CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 | 10.1016/j.bmcl.2005.08.057 | ||
| 44453161 | 195642 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 482 | 4 | 1 | 4 | 4.5 | CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Cl | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL256271 | 195642 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 482 | 4 | 1 | 4 | 4.5 | CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Cl | 10.1016/j.bmcl.2007.09.068 | ||
| 44453435 | 197904 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)ccc1Cl | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL270863 | 197904 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)ccc1Cl | 10.1016/j.bmcl.2007.09.068 | ||
| 44537841 | 1390 | 22 | None | 114 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1016/j.bmcl.2018.11.015 | ||
| 57889181 | 1390 | 22 | None | 114 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1016/j.bmcl.2018.11.015 | ||
| 9497 | 1390 | 22 | None | 114 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL2398716 | 1390 | 22 | None | 114 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL3334824 | 1390 | 22 | None | 114 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1016/j.bmcl.2018.11.015 | ||
| 45138007 | 335004 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 414 | 4 | 1 | 4 | 4.5 | O=C(NCc1cccc(C(F)(F)F)c1)c1cncc2c1cnn2-c1ccc(F)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4448761 | 335004 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 414 | 4 | 1 | 4 | 4.5 | O=C(NCc1cccc(C(F)(F)F)c1)c1cncc2c1cnn2-c1ccc(F)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4638406 | 478355 | 5 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 505 | 5 | 1 | 6 | 3.4 | CCOc1cc(N2C3COCC2CN(C(=O)[C@H]2C[C@H](O)CN2c2ccc(Cl)cc2)C3)ccc1Cl | 10.6019/CHEMBL4630906 | ||
| 71462570 | 163992 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 518 | 5 | 2 | 5 | 5.6 | CC1(C)CN(CC/C=C2/c3cc(C(=O)O)ccc3OCc3ncccc32)C[C@H](c2ccc(Cl)cc2)[C@H]1O | 10.1021/jm300682j | ||
| CHEMBL2178569 | 163992 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 518 | 5 | 2 | 5 | 5.6 | CC1(C)CN(CC/C=C2/c3cc(C(=O)O)ccc3OCc3ncccc32)C[C@H](c2ccc(Cl)cc2)[C@H]1O | 10.1021/jm300682j | ||
| 44453403 | 195510 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1c(Cl)cccc1Cl | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL255629 | 195510 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1c(Cl)cccc1Cl | 10.1016/j.bmcl.2007.09.068 | ||
| 44453202 | 195665 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 422 | 7 | 2 | 4 | 3.3 | Cc1ccccc1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL256404 | 195665 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 422 | 7 | 2 | 4 | 3.3 | Cc1ccccc1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 11743399 | 144696 | 8 | None | 32 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 429 | 5 | 1 | 3 | 4.2 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL198949 | 144696 | 8 | None | 32 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 429 | 5 | 1 | 3 | 4.2 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 10072252 | 144831 | 0 | None | 17 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 446 | 5 | 1 | 4 | 4.1 | CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL199412 | 144831 | 0 | None | 17 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 446 | 5 | 1 | 4 | 4.1 | CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 11554849 | 145064 | 0 | None | 2 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 484 | 7 | 1 | 4 | 3.9 | CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL200242 | 145064 | 0 | None | 2 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 484 | 7 | 1 | 4 | 3.9 | CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 | 10.1016/j.bmcl.2005.08.057 | ||
| 44405211 | 271068 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 441 | 5 | 1 | 3 | 4.3 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CC2CCC(C1)N2Cc1ccc(F)cc1 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL371248 | 271068 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 441 | 5 | 1 | 3 | 4.3 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CC2CCC(C1)N2Cc1ccc(F)cc1 | 10.1016/j.bmcl.2005.08.057 | ||
| 9980155 | 144042 | 0 | None | -23 | 2 | Mouse | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 430 | 5 | 2 | 3 | 3.7 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL196860 | 144042 | 0 | None | -23 | 2 | Mouse | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 430 | 5 | 2 | 3 | 3.7 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O | 10.1016/j.bmcl.2005.08.057 | ||
| 10072252 | 144831 | 0 | None | 17 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 446 | 5 | 1 | 4 | 4.1 | CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL199412 | 144831 | 0 | None | 17 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 446 | 5 | 1 | 4 | 4.1 | CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 44405202 | 145203 | 0 | None | -17 | 2 | Mouse | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 442 | 4 | 2 | 3 | 4.3 | CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL200794 | 145203 | 0 | None | -17 | 2 | Mouse | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 442 | 4 | 2 | 3 | 4.3 | CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 | 10.1016/j.bmcl.2005.08.057 | ||
| 44405181 | 260685 | 0 | None | -51 | 2 | Mouse | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 432 | 6 | 2 | 4 | 3.6 | CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL370162 | 260685 | 0 | None | -51 | 2 | Mouse | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 432 | 6 | 2 | 4 | 3.6 | CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 9804868 | 67454 | 1 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 472 | 5 | 1 | 4 | 6.0 | N#CC1(CCCN2CCC(O)(c3ccc(F)cc3)CC2)c2ccccc2CSc2ccccc21 | 10.1021/jm990316l | ||
| CHEMBL142318 | 67454 | 1 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 472 | 5 | 1 | 4 | 6.0 | N#CC1(CCCN2CCC(O)(c3ccc(F)cc3)CC2)c2ccccc2CSc2ccccc21 | 10.1021/jm990316l | ||
| 44309122 | 202876 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 482 | 11 | 4 | 6 | 3.4 | CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NO | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL305423 | 202876 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 482 | 11 | 4 | 6 | 3.4 | CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NO | 10.1016/j.bmcl.2004.02.022 | ||
| 1370410 | 177778 | 10 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 404 | 3 | 0 | 4 | 3.4 | Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2013.01.005 | ||
| CHEMBL2322888 | 177778 | 10 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 404 | 3 | 0 | 4 | 3.4 | Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2013.01.005 | ||
| 11743399 | 144696 | 8 | None | 32 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 429 | 5 | 1 | 3 | 4.2 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL198949 | 144696 | 8 | None | 32 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 429 | 5 | 1 | 3 | 4.2 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 10811393 | 78377 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 407 | 7 | 1 | 4 | 4.8 | N#CCC(C#N)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/jm990316l | ||
| CHEMBL143194 | 78377 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 407 | 7 | 1 | 4 | 4.8 | N#CCC(C#N)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/jm990316l | ||
| 44453227 | 195768 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 548 | 4 | 1 | 4 | 4.5 | O=S(=O)(c1c(F)cc(F)cc1Br)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL256887 | 195768 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 548 | 4 | 1 | 4 | 4.5 | O=S(=O)(c1c(F)cc(F)cc1Br)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 10649043 | 78046 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 499 | 5 | 1 | 4 | 5.5 | CN1C(=O)c2ccccc2C(C#N)(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc21 | 10.1021/jm990316l | ||
| CHEMBL142925 | 78046 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 499 | 5 | 1 | 4 | 5.5 | CN1C(=O)c2ccccc2C(C#N)(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc21 | 10.1021/jm990316l | ||
| 45138010 | 335404 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 425 | 5 | 1 | 7 | 2.3 | CS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cn1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4454067 | 335404 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 425 | 5 | 1 | 7 | 2.3 | CS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cn1 | 10.1016/j.bmcl.2018.12.024 | ||
| 25233754 | 353229 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 473 | 4 | 1 | 2 | 5.7 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1Cl | 10.1021/jm801416q | ||
| CHEMBL473531 | 353229 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 473 | 4 | 1 | 2 | 5.7 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1Cl | 10.1021/jm801416q | ||
| 44453469 | 196095 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1Cl | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL258360 | 196095 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1Cl | 10.1016/j.bmcl.2007.09.068 | ||
| 155526212 | 335579 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 406 | 4 | 1 | 2 | 5.7 | Cc1cc(C(=O)NCc2cccc(C(F)(F)F)c2)c(C)n1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL4456839 | 335579 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 406 | 4 | 1 | 2 | 5.7 | Cc1cc(C(=O)NCc2cccc(C(F)(F)F)c2)c(C)n1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2018.11.015 | ||
| 44453437 | 316435 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL411477 | 316435 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2007.09.068 | ||
| 44405180 | 277910 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 431 | 6 | 1 | 3 | 4.1 | CC(=O)Nc1cc(Cl)ccc1CCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL381446 | 277910 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 431 | 6 | 1 | 3 | 4.1 | CC(=O)Nc1cc(Cl)ccc1CCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 44453165 | 196097 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 492 | 8 | 2 | 5 | 3.9 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(OC(F)(F)F)cc1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL258362 | 196097 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 492 | 8 | 2 | 5 | 3.9 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(OC(F)(F)F)cc1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44453263 | 311580 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 442 | 7 | 2 | 4 | 3.6 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL404732 | 311580 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 442 | 7 | 2 | 4 | 3.6 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44430755 | 309540 | 0 | None | 42 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 577 | 10 | 2 | 8 | 3.9 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| CHEMBL397910 | 309540 | 0 | None | 42 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 577 | 10 | 2 | 8 | 3.9 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| 44453528 | 197843 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 414 | 7 | 2 | 5 | 3.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccsc1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL270564 | 197843 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 414 | 7 | 2 | 5 | 3.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccsc1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44430753 | 279194 | 0 | None | 77 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 598 | 11 | 3 | 9 | 2.2 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| CHEMBL387608 | 279194 | 0 | None | 77 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 598 | 11 | 3 | 9 | 2.2 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| 25252974 | 40088 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 449 | 4 | 1 | 4 | 5.4 | O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1nncn1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.07.082 | ||
| CHEMBL1224188 | 40088 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 449 | 4 | 1 | 4 | 5.4 | O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1nncn1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.07.082 | ||
| 17753030 | 177887 | 0 | None | 39 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 486 | 7 | 2 | 7 | 2.5 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(N)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| CHEMBL232441 | 177887 | 0 | None | 39 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 486 | 7 | 2 | 7 | 2.5 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(N)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| 10434371 | 145166 | 0 | None | 5 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 459 | 6 | 1 | 4 | 4.2 | COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL200629 | 145166 | 0 | None | 5 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 459 | 6 | 1 | 4 | 4.2 | COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl | 10.1016/j.bmcl.2005.08.057 | ||
| 44405176 | 272843 | 0 | None | -1 | 2 | Mouse | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 471 | 6 | 1 | 4 | 4.3 | COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL372807 | 272843 | 0 | None | -1 | 2 | Mouse | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 471 | 6 | 1 | 4 | 4.3 | COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl | 10.1016/j.bmcl.2005.08.057 | ||
| 58138789 | 336834 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 438 | 6 | 2 | 5 | 3.0 | CNS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4475237 | 336834 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 438 | 6 | 2 | 5 | 3.0 | CNS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| 21070989 | 177765 | 0 | None | 354 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | ||
| CHEMBL2322875 | 177765 | 0 | None | 354 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | ||
| 44453291 | 197729 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 442 | 7 | 2 | 4 | 3.6 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Cl | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL269957 | 197729 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 442 | 7 | 2 | 4 | 3.6 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Cl | 10.1016/j.bmcl.2007.09.068 | ||
| 44453361 | 332112 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 456 | 7 | 2 | 4 | 4.0 | Cc1cccc(Cl)c1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL429419 | 332112 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 456 | 7 | 2 | 4 | 4.0 | Cc1cccc(Cl)c1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 512282 | 1562 | 44 | None | 141 | 4 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.08.057 | ||
| 767 | 1562 | 44 | None | 141 | 4 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL232656 | 1562 | 44 | None | 141 | 4 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.08.057 | ||
| 11554849 | 145064 | 0 | None | -2 | 2 | Mouse | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 484 | 7 | 1 | 4 | 3.9 | CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL200242 | 145064 | 0 | None | -2 | 2 | Mouse | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 484 | 7 | 1 | 4 | 3.9 | CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 | 10.1016/j.bmcl.2005.08.057 | ||
| 9980155 | 144042 | 0 | None | 23 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 430 | 5 | 2 | 3 | 3.7 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL196860 | 144042 | 0 | None | 23 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 430 | 5 | 2 | 3 | 3.7 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O | 10.1016/j.bmcl.2005.08.057 | ||
| 9845614 | 239888 | 19 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 430 | 6 | 1 | 3 | 5.5 | N#CC(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | ||
| CHEMBL357919 | 239888 | 19 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 430 | 6 | 1 | 3 | 5.5 | N#CC(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | ||
| CHEMBL3138115 | 477899 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 1034 | 20 | 6 | 8 | 11.9 | CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc(B(O)O)c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc(B(O)O)c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C | 10.1016/s0960-894x(00)00601-6 | ||
| CHEMBL3138540 | 477899 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 1034 | 20 | 6 | 8 | 11.9 | CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc(B(O)O)c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc(B(O)O)c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C | 10.1016/s0960-894x(00)00601-6 | ||
| 59278474 | 336657 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 451 | 6 | 1 | 7 | 2.8 | O=C(NCc1ccnc(S(=O)(=O)C2CC2)c1)c1cncc2c1cnn2-c1ccc(F)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4472994 | 336657 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 451 | 6 | 1 | 7 | 2.8 | O=C(NCc1ccnc(S(=O)(=O)C2CC2)c1)c1cncc2c1cnn2-c1ccc(F)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| 11554849 | 145064 | 0 | None | 2 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 484 | 7 | 1 | 4 | 3.9 | CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL200242 | 145064 | 0 | None | 2 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 484 | 7 | 1 | 4 | 3.9 | CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 | 10.1016/j.bmcl.2005.08.057 | ||
| 44453321 | 197795 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 502 | 4 | 1 | 4 | 4.8 | O=S(=O)(c1c(Cl)cccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL270254 | 197795 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 502 | 4 | 1 | 4 | 4.8 | O=S(=O)(c1c(Cl)cccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 155561040 | 349376 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 418 | 6 | 2 | 5 | 2.7 | CNS(=O)(=O)c1ccc(CNC(=O)c2cnn(-c3ccc(Cl)cc3)c2C)cc1 | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL4574870 | 349376 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 418 | 6 | 2 | 5 | 2.7 | CNS(=O)(=O)c1ccc(CNC(=O)c2cnn(-c3ccc(Cl)cc3)c2C)cc1 | 10.1016/j.bmcl.2018.11.015 | ||
| 44453290 | 197728 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 482 | 4 | 1 | 4 | 4.4 | Cc1cccc(Cl)c1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL269956 | 197728 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 482 | 4 | 1 | 4 | 4.4 | Cc1cccc(Cl)c1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 59278286 | 336088 | 1 | None | -112 | 2 | Mouse | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 453 | 6 | 1 | 7 | 3.2 | CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4464625 | 336088 | 1 | None | -112 | 2 | Mouse | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 453 | 6 | 1 | 7 | 3.2 | CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| 44469942 | 348976 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 452 | 6 | 1 | 5 | 3.3 | CN(C)S(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4565496 | 348976 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 452 | 6 | 1 | 5 | 3.3 | CN(C)S(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| 25233582 | 373199 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 401 | 5 | 1 | 3 | 4.0 | COc1ccc(NC(=O)N2CCC[C@@H]2C(=O)N(C)Cc2ccc(Cl)cc2)cc1 | 10.1021/jm801416q | ||
| CHEMBL517290 | 373199 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 401 | 5 | 1 | 3 | 4.0 | COc1ccc(NC(=O)N2CCC[C@@H]2C(=O)N(C)Cc2ccc(Cl)cc2)cc1 | 10.1021/jm801416q | ||
| 44309245 | 468458 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 556 | 13 | 3 | 5 | 5.2 | CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NCc1ccccc1 | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL65784 | 468458 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 556 | 13 | 3 | 5 | 5.2 | CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NCc1ccccc1 | 10.1016/j.bmcl.2004.02.022 | ||
| 10001921 | 144665 | 0 | None | -3 | 2 | Mouse | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 415 | 5 | 1 | 3 | 3.8 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL198852 | 144665 | 0 | None | -3 | 2 | Mouse | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 415 | 5 | 1 | 3 | 3.8 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2005.08.057 | ||
| 9980155 | 144042 | 0 | None | 23 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 430 | 5 | 2 | 3 | 3.7 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL196860 | 144042 | 0 | None | 23 | 2 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 430 | 5 | 2 | 3 | 3.7 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O | 10.1016/j.bmcl.2005.08.057 | ||
| 45138012 | 334767 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 414 | 4 | 1 | 4 | 4.5 | O=C(NCc1cccc(C(F)(F)F)c1)c1nccc2c1cnn2-c1ccc(F)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4445316 | 334767 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 414 | 4 | 1 | 4 | 4.5 | O=C(NCc1cccc(C(F)(F)F)c1)c1nccc2c1cnn2-c1ccc(F)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| 58138781 | 349123 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 379 | 4 | 1 | 3 | 4.7 | O=C(NCc1cccc(Cl)c1)c1cccc2c1cnn2-c1ccc(F)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4568987 | 349123 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 379 | 4 | 1 | 3 | 4.7 | O=C(NCc1cccc(Cl)c1)c1cccc2c1cnn2-c1ccc(F)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| 44453198 | 195981 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 516 | 4 | 1 | 4 | 5.2 | CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2c(Cl)cccc2Cl)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL257853 | 195981 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 516 | 4 | 1 | 4 | 5.2 | CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2c(Cl)cccc2Cl)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44430746 | 177992 | 0 | None | 41 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 530 | 10 | 3 | 8 | 2.3 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| CHEMBL232638 | 177992 | 0 | None | 41 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 530 | 10 | 3 | 8 | 2.3 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| 44480348 | 349760 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 446 | 7 | 1 | 6 | 3.9 | CCCC(NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1ccc(S(C)(=O)=O)nc1 | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL4583870 | 349760 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 446 | 7 | 1 | 6 | 3.9 | CCCC(NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1ccc(S(C)(=O)=O)nc1 | 10.1016/j.bmcl.2018.11.015 | ||
| 44453639 | 314727 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 482 | 4 | 1 | 4 | 4.4 | Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL409498 | 314727 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 482 | 4 | 1 | 4 | 4.4 | Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44405203 | 144699 | 0 | None | -31 | 2 | Mouse | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 443 | 4 | 1 | 4 | 4.5 | CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL198966 | 144699 | 0 | None | -31 | 2 | Mouse | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 443 | 4 | 1 | 4 | 4.5 | CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 | 10.1016/j.bmcl.2005.08.057 | ||
| 10503785 | 239731 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 451 | 7 | 1 | 4 | 5.3 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)N1CCCCC1 | 10.1021/jm990316l | ||
| CHEMBL357434 | 239731 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 451 | 7 | 1 | 4 | 5.3 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)N1CCCCC1 | 10.1021/jm990316l | ||
| 59687824 | 155196 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 469 | 5 | 1 | 5 | 3.6 | CO[C@@H]1COCC[C@@H]1NC1CC[C@@](C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)(C(C)C)C1 | 10.1021/jm300682j | ||
| CHEMBL2178572 | 155196 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 469 | 5 | 1 | 5 | 3.6 | CO[C@@H]1COCC[C@@H]1NC1CC[C@@](C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)(C(C)C)C1 | 10.1021/jm300682j | ||
| 44430753 | 279194 | 0 | None | 77 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 598 | 11 | 3 | 9 | 2.2 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| CHEMBL387608 | 279194 | 0 | None | 77 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 598 | 11 | 3 | 9 | 2.2 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| 44470083 | 336111 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 466 | 7 | 2 | 5 | 3.8 | CC(C)NS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4465000 | 336111 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 466 | 7 | 2 | 5 | 3.8 | CC(C)NS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| 44309312 | 468765 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 460 | 9 | 3 | 5 | 3.4 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCCCC1 | 10.1016/j.bmcl.2004.02.022 | ||
| 44309337 | 468765 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 460 | 9 | 3 | 5 | 3.4 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCCCC1 | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL68145 | 468765 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 460 | 9 | 3 | 5 | 3.4 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCCCC1 | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL69375 | 468765 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 460 | 9 | 3 | 5 | 3.4 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCCCC1 | 10.1016/j.bmcl.2004.02.022 | ||
| 21070989 | 177765 | 0 | None | 354 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | ||
| CHEMBL2322875 | 177765 | 0 | None | 354 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | ||
| 44453200 | 196032 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 476 | 7 | 2 | 4 | 4.0 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1C(F)(F)F | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL258065 | 196032 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 476 | 7 | 2 | 4 | 4.0 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1C(F)(F)F | 10.1016/j.bmcl.2007.09.068 | ||
| 44405181 | 260685 | 0 | None | 51 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 432 | 6 | 2 | 4 | 3.6 | CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL370162 | 260685 | 0 | None | 51 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 432 | 6 | 2 | 4 | 3.6 | CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 10434371 | 145166 | 0 | None | -5 | 2 | Mouse | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 459 | 6 | 1 | 4 | 4.2 | COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL200629 | 145166 | 0 | None | -5 | 2 | Mouse | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 459 | 6 | 1 | 4 | 4.2 | COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl | 10.1016/j.bmcl.2005.08.057 | ||
| 44405212 | 145177 | 0 | None | -1 | 2 | Mouse | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 458 | 5 | 1 | 4 | 4.2 | CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL200680 | 145177 | 0 | None | -1 | 2 | Mouse | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 458 | 5 | 1 | 4 | 4.2 | CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 | 10.1016/j.bmcl.2005.08.057 | ||
| 155549724 | 347937 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 427 | 4 | 1 | 3 | 5.4 | Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL4539264 | 347937 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 427 | 4 | 1 | 3 | 5.4 | Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2018.11.015 | ||
| 10388824 | 270926 | 0 | None | -4 | 2 | Mouse | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 445 | 5 | 1 | 3 | 4.7 | CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL370596 | 270926 | 0 | None | -4 | 2 | Mouse | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 445 | 5 | 1 | 3 | 4.7 | CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 9870185 | 175084 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 489 | 7 | 3 | 5 | 3.5 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2207666 | 175084 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 489 | 7 | 3 | 5 | 3.5 | O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 | 10.1016/j.bmcl.2012.09.113 | ||
| 162658125 | 354955 | 0 | None | -125 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | ||
| CHEMBL4760108 | 354955 | 0 | None | -125 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 471 | 6 | 2 | 4 | 5.9 | O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | ||
| 162666730 | 356101 | 1 | None | -707 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 589 | 9 | 2 | 6 | 6.5 | N#CSCCNC(=O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | ||
| CHEMBL4783861 | 356101 | 1 | None | -707 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 589 | 9 | 2 | 6 | 6.5 | N#CSCCNC(=O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 | 10.1021/acs.jmedchem.0c01137 | ||
| 44453436 | 197950 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 458 | 7 | 2 | 4 | 4.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL271079 | 197950 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 458 | 7 | 2 | 4 | 4.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44453293 | 332188 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 486 | 7 | 2 | 4 | 3.8 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Br | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL429591 | 332188 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 486 | 7 | 2 | 4 | 3.8 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Br | 10.1016/j.bmcl.2007.09.068 | ||
| 9869274 | 238077 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 468 | 5 | 1 | 3 | 6.4 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2C=Cc2ccccc21 | 10.1021/jm990316l | ||
| CHEMBL344073 | 238077 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 468 | 5 | 1 | 3 | 6.4 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2C=Cc2ccccc21 | 10.1021/jm990316l | ||
| 44430745 | 279221 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 544 | 11 | 2 | 8 | 3.0 | COCCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| CHEMBL387822 | 279221 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 544 | 11 | 2 | 8 | 3.0 | COCCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| 10111333 | 349467 | 0 | None | -19 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 395 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | ||
| CHEMBL4577133 | 349467 | 0 | None | -19 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 395 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | ||
| 58138841 | 334206 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 438 | 6 | 2 | 5 | 3.0 | CNS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4437170 | 334206 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 438 | 6 | 2 | 5 | 3.0 | CNS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| 512282 | 1562 | 44 | None | 141 | 4 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.08.057 | ||
| 767 | 1562 | 44 | None | 141 | 4 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL232656 | 1562 | 44 | None | 141 | 4 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2005.08.057 | ||
| 44405202 | 145203 | 0 | None | 17 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 442 | 4 | 2 | 3 | 4.3 | CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL200794 | 145203 | 0 | None | 17 | 2 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 442 | 4 | 2 | 3 | 4.3 | CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 | 10.1016/j.bmcl.2005.08.057 | ||
| 10576419 | 77690 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 472 | 9 | 1 | 3 | 6.7 | N#CC(CCCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | ||
| CHEMBL142620 | 77690 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 472 | 9 | 1 | 3 | 6.7 | N#CC(CCCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | ||
| CHEMBL3138380 | 477898 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 1036 | 20 | 2 | 8 | 16.3 | CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc([N+](=O)[O-])c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc([N+](=O)[O-])c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C | 10.1016/s0960-894x(00)00601-6 | ||
| CHEMBL3138437 | 477898 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 1036 | 20 | 2 | 8 | 16.3 | CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc([N+](=O)[O-])c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc([N+](=O)[O-])c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C | 10.1016/s0960-894x(00)00601-6 | ||
| 10001921 | 144665 | 0 | None | 3 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 415 | 5 | 1 | 3 | 3.8 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL198852 | 144665 | 0 | None | 3 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 415 | 5 | 1 | 3 | 3.8 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2005.08.057 | ||
| 11743399 | 144696 | 8 | None | -32 | 2 | Mouse | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 429 | 5 | 1 | 3 | 4.2 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL198949 | 144696 | 8 | None | -32 | 2 | Mouse | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 429 | 5 | 1 | 3 | 4.2 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 10572669 | 238197 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 393 | 6 | 1 | 4 | 4.6 | N#Cc1ccccc1C(C#N)CCCN1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm990316l | ||
| CHEMBL344989 | 238197 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 393 | 6 | 1 | 4 | 4.6 | N#Cc1ccccc1C(C#N)CCCN1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm990316l | ||
| 3497 | 2447 | 26 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1016/j.bmcl.2018.11.015 | ||
| 44309353 | 2447 | 26 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1016/j.bmcl.2018.11.015 | ||
| 5311123 | 2447 | 26 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL1628706 | 2447 | 26 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL308473 | 2447 | 26 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1016/j.bmcl.2018.11.015 | ||
| 44453499 | 311371 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 486 | 4 | 1 | 4 | 4.3 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL403613 | 311371 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 486 | 4 | 1 | 4 | 4.3 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 10111333 | 349467 | 0 | None | -19 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 395 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | ||
| CHEMBL4577133 | 349467 | 0 | None | -19 | 2 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 395 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | ||
| 44430748 | 178095 | 0 | None | 72 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 529 | 10 | 3 | 8 | 2.3 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| CHEMBL232837 | 178095 | 0 | None | 72 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 529 | 10 | 3 | 8 | 2.3 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| 44430758 | 279954 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 482 | 6 | 2 | 6 | 3.1 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1Nc1c(N)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| CHEMBL389293 | 279954 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 482 | 6 | 2 | 6 | 3.1 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1Nc1c(N)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| 25233756 | 354749 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 467 | 4 | 1 | 2 | 5.6 | Cc1cc(C(F)(F)F)cc(C)c1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1 | 10.1021/jm801416q | ||
| CHEMBL475748 | 354749 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 467 | 4 | 1 | 2 | 5.6 | Cc1cc(C(F)(F)F)cc(C)c1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1 | 10.1021/jm801416q | ||
| 58138880 | 336873 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 452 | 6 | 1 | 5 | 3.3 | CN(C)S(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4475918 | 336873 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 452 | 6 | 1 | 5 | 3.3 | CN(C)S(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| 44405212 | 145177 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 458 | 5 | 1 | 4 | 4.2 | CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL200680 | 145177 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 458 | 5 | 1 | 4 | 4.2 | CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 | 10.1016/j.bmcl.2005.08.057 | ||
| 25253284 | 40074 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 450 | 4 | 1 | 5 | 4.8 | O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1nnnn1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.07.082 | ||
| CHEMBL1224119 | 40074 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 450 | 4 | 1 | 5 | 4.8 | O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1nnnn1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.07.082 | ||
| 59278314 | 334482 | 29 | None | 54 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 425 | 5 | 1 | 7 | 2.3 | CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4441094 | 334482 | 29 | None | 54 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 425 | 5 | 1 | 7 | 2.3 | CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1 | 10.1016/j.bmcl.2018.12.024 | ||
| 11211557 | 334419 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 393 | 4 | 1 | 3 | 4.8 | Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL4440166 | 334419 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 393 | 4 | 1 | 3 | 4.8 | Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc(Cl)cc1 | 10.1016/j.bmcl.2018.11.015 | ||
| 10456104 | 144205 | 0 | None | -56 | 2 | Mouse | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 443 | 5 | 1 | 3 | 4.6 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL197375 | 144205 | 0 | None | -56 | 2 | Mouse | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 443 | 5 | 1 | 3 | 4.6 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 59278235 | 347198 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 425 | 5 | 1 | 7 | 2.3 | CS(=O)(=O)c1cncc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4519965 | 347198 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 425 | 5 | 1 | 7 | 2.3 | CS(=O)(=O)c1cncc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| 44468708 | 348731 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 423 | 5 | 1 | 5 | 3.5 | CS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4559388 | 348731 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 423 | 5 | 1 | 5 | 3.5 | CS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| 44453466 | 311588 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 486 | 4 | 1 | 4 | 4.3 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)c(F)c3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL404757 | 311588 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 486 | 4 | 1 | 4 | 4.3 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)c(F)c3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44453502 | 311135 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 468 | 4 | 1 | 4 | 4.1 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3cccc(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL402110 | 311135 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 468 | 4 | 1 | 4 | 4.1 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3cccc(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 3497 | 2447 | 26 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1016/j.bmcl.2004.02.022 | ||
| 44309353 | 2447 | 26 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1016/j.bmcl.2004.02.022 | ||
| 5311123 | 2447 | 26 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL1628706 | 2447 | 26 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL308473 | 2447 | 26 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1016/j.bmcl.2004.02.022 | ||
| 44453226 | 196101 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 536 | 4 | 1 | 4 | 5.4 | O=S(=O)(c1ccc(Cl)c(Cl)c1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL258369 | 196101 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 536 | 4 | 1 | 4 | 5.4 | O=S(=O)(c1ccc(Cl)c(Cl)c1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 59278314 | 334482 | 29 | None | -54 | 2 | Mouse | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 425 | 5 | 1 | 7 | 2.3 | CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4441094 | 334482 | 29 | None | -54 | 2 | Mouse | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 425 | 5 | 1 | 7 | 2.3 | CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1 | 10.1016/j.bmcl.2018.12.024 | ||
| 44468570 | 336398 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 423 | 5 | 1 | 5 | 3.5 | CS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4469176 | 336398 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 423 | 5 | 1 | 5 | 3.5 | CS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 | 10.1016/j.bmcl.2018.12.024 | ||
| 44309219 | 202205 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 512 | 9 | 4 | 6 | 2.8 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1(O)CCC(F)(F)CC1 | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL302320 | 202205 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 512 | 9 | 4 | 6 | 2.8 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1(O)CCC(F)(F)CC1 | 10.1016/j.bmcl.2004.02.022 | ||
| 44309313 | 202594 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | CC(C)(O)CCC(C[C@H](O)[C@H](Cc1ccccc1F)NC(=O)c1cnc2ccccc2n1)C(N)=O | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL304053 | 202594 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | CC(C)(O)CCC(C[C@H](O)[C@H](Cc1ccccc1F)NC(=O)c1cnc2ccccc2n1)C(N)=O | 10.1016/j.bmcl.2004.02.022 | ||
| 10434371 | 145166 | 0 | None | 5 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 459 | 6 | 1 | 4 | 4.2 | COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL200629 | 145166 | 0 | None | 5 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 459 | 6 | 1 | 4 | 4.2 | COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl | 10.1016/j.bmcl.2005.08.057 | ||
| 17753030 | 177887 | 0 | None | 39 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 486 | 7 | 2 | 7 | 2.5 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(N)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| CHEMBL232441 | 177887 | 0 | None | 39 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 486 | 7 | 2 | 7 | 2.5 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(N)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| 44405176 | 272843 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 471 | 6 | 1 | 4 | 4.3 | COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL372807 | 272843 | 0 | None | 1 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 471 | 6 | 1 | 4 | 4.3 | COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl | 10.1016/j.bmcl.2005.08.057 | ||
| 44405176 | 272843 | 0 | None | 1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 471 | 6 | 1 | 4 | 4.3 | COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL372807 | 272843 | 0 | None | 1 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 471 | 6 | 1 | 4 | 4.3 | COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl | 10.1016/j.bmcl.2005.08.057 | ||
| 44453529 | 198142 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 414 | 7 | 2 | 5 | 3.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccs1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL272097 | 198142 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 414 | 7 | 2 | 5 | 3.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccs1 | 10.1016/j.bmcl.2007.09.068 | ||
| 10076510 | 25915 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 433 | 6 | 1 | 2 | 6.0 | C[N+]1(CCCC(C#N)c2ccc3ccccc3c2)CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm990316l | ||
| CHEMBL1180795 | 25915 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 433 | 6 | 1 | 2 | 6.0 | C[N+]1(CCCC(C#N)c2ccc3ccccc3c2)CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm990316l | ||
| 5311125 | 78652 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 488 | 5 | 1 | 4 | 6.5 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2CSc2ccccc21 | 10.1021/jm990316l | ||
| CHEMBL143492 | 78652 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 488 | 5 | 1 | 4 | 6.5 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2CSc2ccccc21 | 10.1021/jm990316l | ||
| 10717972 | 238111 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 440 | 8 | 1 | 5 | 4.4 | CCOC(=O)C(C#N)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/jm990316l | ||
| CHEMBL344324 | 238111 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 440 | 8 | 1 | 5 | 4.4 | CCOC(=O)C(C#N)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/jm990316l | ||
| 44309077 | 469245 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 549 | 11 | 2 | 6 | 3.6 | CN1CCN(C(=O)C(CCC(C)(C)F)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)c2cnc3ccccc3n2)CC1 | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL71499 | 469245 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 549 | 11 | 2 | 6 | 3.6 | CN1CCN(C(=O)C(CCC(C)(C)F)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)c2cnc3ccccc3n2)CC1 | 10.1016/j.bmcl.2004.02.022 | ||
| 10695080 | 26473 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 418 | 6 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 | 10.1021/jm990316l | ||
| CHEMBL1184276 | 26473 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 418 | 6 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 | 10.1021/jm990316l | ||
| 44453163 | 311382 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 454 | 4 | 1 | 5 | 3.9 | CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2cccs2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL403692 | 311382 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 454 | 4 | 1 | 5 | 3.9 | CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2cccs2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44309124 | 468838 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 520 | 11 | 2 | 5 | 4.5 | CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)N1CCCC1 | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL68692 | 468838 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 520 | 11 | 2 | 5 | 4.5 | CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)N1CCCC1 | 10.1016/j.bmcl.2004.02.022 | ||
| 58138788 | 335697 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 395 | 4 | 1 | 3 | 5.0 | O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccccc1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4458721 | 335697 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 395 | 4 | 1 | 3 | 5.0 | O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccccc1 | 10.1016/j.bmcl.2018.12.024 | ||
| 9956488 | 238012 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 472 | 5 | 1 | 4 | 5.8 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2COc2ccccc21 | 10.1021/jm990316l | ||
| CHEMBL343511 | 238012 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 472 | 5 | 1 | 4 | 5.8 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2COc2ccccc21 | 10.1021/jm990316l | ||
| 9956380 | 332961 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 470 | 5 | 1 | 3 | 6.0 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2CCc2ccccc21 | 10.1021/jm990316l | ||
| CHEMBL433746 | 332961 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 470 | 5 | 1 | 3 | 6.0 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2CCc2ccccc21 | 10.1021/jm990316l | ||
| 24758044 | 164277 | 0 | None | 5 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | ||
| 57888953 | 164277 | 0 | None | 5 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | ||
| 71455572 | 164277 | 0 | None | 5 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | ||
| CHEMBL2180523 | 164277 | 0 | None | 5 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | ||
| CHEMBL2180528 | 164277 | 0 | None | 5 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | ||
| CHEMBL2180534 | 164277 | 0 | None | 5 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | ||
| 37664972 | 335049 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 377 | 4 | 1 | 3 | 4.3 | Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc(F)cc1 | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL4449368 | 335049 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 377 | 4 | 1 | 3 | 4.3 | Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc(F)cc1 | 10.1016/j.bmcl.2018.11.015 | ||
| 44453317 | 197751 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 480 | 5 | 1 | 5 | 4.2 | CSc1ccc(C2(O)CCN(C3CCN(S(=O)(=O)c4ccccc4Cl)CC3)CC2)cc1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL270033 | 197751 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 480 | 5 | 1 | 5 | 4.2 | CSc1ccc(C2(O)CCN(C3CCN(S(=O)(=O)c4ccccc4Cl)CC3)CC2)cc1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44430755 | 309540 | 0 | None | 42 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 577 | 10 | 2 | 8 | 3.9 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| CHEMBL397910 | 309540 | 0 | None | 42 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 577 | 10 | 2 | 8 | 3.9 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | ||
| 59278123 | 336868 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 424 | 5 | 1 | 6 | 2.9 | CS(=O)(=O)c1cccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| CHEMBL4475801 | 336868 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 424 | 5 | 1 | 6 | 2.9 | CS(=O)(=O)c1cccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)c1 | 10.1016/j.bmcl.2018.12.024 | ||
| 44309286 | 202416 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 512 | 9 | 4 | 6 | 3.7 | O=C(N[C@@H](Cc1ccccc1)[C@@H](O)CC(C(=O)NO)C1CCC(F)(F)CC1)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL303673 | 202416 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 512 | 9 | 4 | 6 | 3.7 | O=C(N[C@@H](Cc1ccccc1)[C@@H](O)CC(C(=O)NO)C1CCC(F)(F)CC1)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.022 | ||
| 44453228 | 195769 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 426 | 7 | 2 | 4 | 3.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1F | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL256888 | 195769 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 426 | 7 | 2 | 4 | 3.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1F | 10.1016/j.bmcl.2007.09.068 | ||
| 10388824 | 270926 | 0 | None | 4 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 445 | 5 | 1 | 3 | 4.7 | CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL370596 | 270926 | 0 | None | 4 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 445 | 5 | 1 | 3 | 4.7 | CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 44405196 | 277849 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 460 | 5 | 2 | 4 | 3.8 | COc1cc2c(cc1Cl)NC(=O)NC2CC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL381223 | 277849 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 460 | 5 | 2 | 4 | 3.8 | COc1cc2c(cc1Cl)NC(=O)NC2CC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 44453641 | 198235 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 438 | 8 | 2 | 5 | 3.0 | COc1ccc(S(=O)(=O)NCCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL272559 | 198235 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 438 | 8 | 2 | 5 | 3.0 | COc1ccc(S(=O)(=O)NCCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmcl.2007.09.068 | ||
| 10789482 | 67301 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 444 | 9 | 1 | 3 | 5.9 | N#CC(CCCCl)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/jm990316l | ||
| CHEMBL142191 | 67301 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 444 | 9 | 1 | 3 | 5.9 | N#CC(CCCCl)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/jm990316l | ||
| 44453584 | 198222 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 484 | 8 | 2 | 4 | 4.7 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1ccccc1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL272523 | 198222 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 484 | 8 | 2 | 4 | 4.7 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1ccccc1 | 10.1016/j.bmcl.2007.09.068 | ||
| 44308819 | 203236 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 453 | 10 | 3 | 4 | 4.5 | CNC(=O)[C@@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.022 | ||
| 44308902 | 203236 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 453 | 10 | 3 | 4 | 4.5 | CNC(=O)[C@@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL308243 | 203236 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 453 | 10 | 3 | 4 | 4.5 | CNC(=O)[C@@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.022 | ||
| CHEMBL68937 | 203236 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 453 | 10 | 3 | 4 | 4.5 | CNC(=O)[C@@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.022 | ||
| 10547456 | 238325 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 374 | 6 | 1 | 4 | 4.8 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccs1 | 10.1021/jm990316l | ||
| CHEMBL346205 | 238325 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 374 | 6 | 1 | 4 | 4.8 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccs1 | 10.1021/jm990316l | ||
| 24758044 | 164277 | 0 | None | 5 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | ||
| 57888953 | 164277 | 0 | None | 5 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | ||
| 71455572 | 164277 | 0 | None | 5 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | ||
| CHEMBL2180523 | 164277 | 0 | None | 5 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | ||
| CHEMBL2180528 | 164277 | 0 | None | 5 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | ||
| CHEMBL2180534 | 164277 | 0 | None | 5 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | ||
| 155514261 | 334402 | 0 | None | 1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 493 | 4 | 1 | 3 | 5.2 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1c1cccc(Br)c1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | ||
| CHEMBL4439854 | 334402 | 0 | None | 1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 493 | 4 | 1 | 3 | 5.2 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1c1cccc(Br)c1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | ||
| 155514261 | 334402 | 0 | None | 1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 493 | 4 | 1 | 3 | 5.2 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1c1cccc(Br)c1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | ||
| CHEMBL4439854 | 334402 | 0 | None | 1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 493 | 4 | 1 | 3 | 5.2 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1c1cccc(Br)c1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | ||
| 10526132 | 144690 | 0 | None | -1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 419 | 7 | 1 | 2 | 6.2 | OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm990316l | ||
| CHEMBL198935 | 144690 | 0 | None | -1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 419 | 7 | 1 | 2 | 6.2 | OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm990316l | ||
| 11554849 | 145064 | 0 | None | 2 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 484 | 7 | 1 | 4 | 3.9 | CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL200242 | 145064 | 0 | None | 2 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 484 | 7 | 1 | 4 | 3.9 | CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 | 10.1016/j.bmcl.2005.08.057 | ||
| 10456104 | 144205 | 0 | None | 56 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 443 | 5 | 1 | 3 | 4.6 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL197375 | 144205 | 0 | None | 56 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 443 | 5 | 1 | 3 | 4.6 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 3536 | 8490 | 0 | None | 9 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 515 | 5 | 1 | 2 | 7.3 | CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 | 10.1021/jm300682j | ||
| 44560289 | 8490 | 0 | None | 9 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 515 | 5 | 1 | 2 | 7.3 | CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 | 10.1021/jm300682j | ||
| CHEMBL1186993 | 8490 | 0 | None | 9 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 515 | 5 | 1 | 2 | 7.3 | CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 | 10.1021/jm300682j | ||
| 44405202 | 145203 | 0 | None | 17 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 442 | 4 | 2 | 3 | 4.3 | CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL200794 | 145203 | 0 | None | 17 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 442 | 4 | 2 | 3 | 4.3 | CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 | 10.1016/j.bmcl.2005.08.057 | ||
| 11743399 | 144696 | 8 | None | 32 | 2 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 429 | 5 | 1 | 3 | 4.2 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| CHEMBL198949 | 144696 | 8 | None | 32 | 2 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 429 | 5 | 1 | 3 | 4.2 | CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2005.08.057 | ||
| 44453359 | 197863 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 408 | 7 | 2 | 4 | 3.0 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL270631 | 197863 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 408 | 7 | 2 | 4 | 3.0 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1016/j.bmcl.2007.09.068 | ||
| 25022507 | 311387 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 512 | 4 | 1 | 4 | 4.2 | O=S(=O)(c1ccccc1Br)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| CHEMBL403728 | 311387 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 512 | 4 | 1 | 4 | 4.2 | O=S(=O)(c1ccccc1Br)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | ||
| 10833944 | 237552 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 384 | 6 | 2 | 4 | 4.4 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(O)c1 | 10.1021/jm990316l | ||
| CHEMBL341840 | 237552 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 384 | 6 | 2 | 4 | 4.4 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(O)c1 | 10.1021/jm990316l | ||
| CHEMBL3138118 | 477895 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 1187 | 22 | 4 | 6 | 19.2 | CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6ccc(-c7cccc(C(=O)O)c7)cc6)c(C(=O)O)c5)c5cc(Cl)c(OCc6ccc(-c7cccc(C(=O)O)c7)cc6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C | 10.1016/s0960-894x(00)00601-6 | ||
| CHEMBL3138133 | 477895 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 1187 | 22 | 4 | 6 | 19.2 | CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6ccc(-c7cccc(C(=O)O)c7)cc6)c(C(=O)O)c5)c5cc(Cl)c(OCc6ccc(-c7cccc(C(=O)O)c7)cc6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C | 10.1016/s0960-894x(00)00601-6 | ||
| 155521447 | 335135 | 0 | None | -3 | 2 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 421 | 4 | 1 | 3 | 4.7 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | ||
| CHEMBL4450561 | 335135 | 0 | None | -3 | 2 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 421 | 4 | 1 | 3 | 4.7 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | ||
| 155521447 | 335135 | 0 | None | -3 | 2 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 421 | 4 | 1 | 3 | 4.7 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | ||
| CHEMBL4450561 | 335135 | 0 | None | -3 | 2 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 421 | 4 | 1 | 3 | 4.7 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | ||
| 155549273 | 347912 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 404 | 5 | 1 | 5 | 4.0 | Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc([N+](=O)[O-])cc1 | 10.1016/j.bmcl.2018.11.015 | ||
| CHEMBL4538794 | 347912 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 404 | 5 | 1 | 5 | 4.0 | Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc([N+](=O)[O-])cc1 | 10.1016/j.bmcl.2018.11.015 | ||
| 10690854 | 66372 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 374 | 6 | 1 | 4 | 4.8 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccsc1 | 10.1021/jm990316l | ||
| CHEMBL141387 | 66372 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 374 | 6 | 1 | 4 | 4.8 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccsc1 | 10.1021/jm990316l | ||
| 49798289 | 24930 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 489 | 6 | 2 | 4 | 5.8 | O=C(O)c1c(F)cccc1Oc1ccc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | ||
| CHEMBL1170391 | 24930 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 489 | 6 | 2 | 4 | 5.8 | O=C(O)c1c(F)cccc1Oc1ccc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | ||
| 49798265 | 25009 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 489 | 6 | 2 | 4 | 5.8 | O=C(O)c1ccccc1Oc1c(F)cc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | ||
| CHEMBL1171006 | 25009 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 489 | 6 | 2 | 4 | 5.8 | O=C(O)c1ccccc1Oc1c(F)cc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | ||
| 10300214 | 175175 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 492 | 9 | 2 | 5 | 5.0 | O=C(Nc1ccccc1OCC(O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)C1CCC1 | 10.1016/j.bmcl.2012.09.113 | ||
| CHEMBL2208416 | 175175 | 0 | None | None | None | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 492 | 9 | 2 | 5 | 5.0 | O=C(Nc1ccccc1OCC(O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)C1CCC1 | 10.1016/j.bmcl.2012.09.113 | ||
| 49798264 | 25068 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 403 | 6 | 2 | 4 | 4.6 | O=C(O)c1ccccc1Oc1ccccc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | ||
| CHEMBL1171758 | 25068 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 403 | 6 | 2 | 4 | 4.6 | O=C(O)c1ccccc1Oc1ccccc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | ||
| 19430534 | 25053 | 0 | None | None | None | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 471 | 6 | 2 | 4 | 5.7 | O=C(O)c1ccccc1Oc1ccc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | ||
| CHEMBL1171586 | 25053 | 0 | None | None | None | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 471 | 6 | 2 | 4 | 5.7 | O=C(O)c1ccccc1Oc1ccc(C(F)(F)F)cc1NS(=O)(=O)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.04.142 | ||
| 15664 | 174775 | 66 | None | -3 | 3 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Drug Central | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | None | ||
| 5403 | 174775 | 66 | None | -3 | 3 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Drug Central | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | None | ||
| CHEMBL2205807 | 174775 | 66 | None | -3 | 3 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Drug Central | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | None | ||
| DB11932 | 174775 | 66 | None | -3 | 3 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Drug Central | 184 | 1 | 0 | 2 | 2.8 | Cc1ccc(-c2ccc(C)cn2)nc1 | None | ||
| 3536 | 8490 | 0 | None | 9 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Guide to Pharmacology | 515 | 5 | 1 | 2 | 7.3 | CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 | 10854442 | ||
| 44560289 | 8490 | 0 | None | 9 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Guide to Pharmacology | 515 | 5 | 1 | 2 | 7.3 | CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 | 10854442 | ||
| CHEMBL1186993 | 8490 | 0 | None | 9 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Functional | Guide to Pharmacology | 515 | 5 | 1 | 2 | 7.3 | CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 | 10854442 | ||
| 4382 | 1724 | 0 | None | -25 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | Guide to Pharmacology | None | None | None | None | 23951310 | ||||
| P55774 | 1724 | 0 | None | -25 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | Guide to Pharmacology | None | None | None | None | 23951310 | ||||
| 754 | 1718 | 0 | None | -5 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | Guide to Pharmacology | None | None | None | None | 9346309 | ||||
| Q16663 | 1718 | 0 | None | -5 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | Guide to Pharmacology | None | None | None | None | 9346309 | ||||
| 3696 | 2178 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 584 | 6 | 2 | 5 | 6.0 | NC[C@@H]1CCCN(C1)C(=O)c1ccc2c(c1)C(C(=O)NC1CCN(CC1)CC1=CCCCCCCC1)c1c(O2)cccc1 | 12614873 | ||
| 73755059 | 2178 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Functional | Guide to Pharmacology | 584 | 6 | 2 | 5 | 6.0 | NC[C@@H]1CCCN(C1)C(=O)c1ccc2c(c1)C(C(=O)NC1CCN(CC1)CC1=CCCCCCCC1)c1c(O2)cccc1 | 12614873 | ||
| 10750 | 5246 | 0 | None | 5011 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | Guide to Pharmacology | 532 | 5 | 2 | 5 | 6.3 | Clc1ccc(cc1)C1(O)CCN(CC1(C)C)CC/C=C\1/c2cc(ccc2OCc2c1cccn2)C(O)(C)C | None | ||
| 18437138 | 5246 | 0 | None | 5011 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | Guide to Pharmacology | 532 | 5 | 2 | 5 | 6.3 | Clc1ccc(cc1)C1(O)CCN(CC1(C)C)CC/C=C\1/c2cc(ccc2OCc2c1cccn2)C(O)(C)C | None | ||
| 486830 | 8678 | 0 | None | -10 | 5 | Human | 8.1 | pIC50 | None | 8.1 | Functional | Guide to Pharmacology | 1308 | 22 | 19 | 19 | -5.9 | NCCCC[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC1=O)CCCN=C(N)N)CCCN=C(N)N)CCC(=O)N)C(C)C)C(=O)O)[C@H](O)C | 9287217 | ||
| 768 | 8678 | 0 | None | -10 | 5 | Human | 8.1 | pIC50 | None | 8.1 | Functional | Guide to Pharmacology | 1308 | 22 | 19 | 19 | -5.9 | NCCCC[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC1=O)CCCN=C(N)N)CCCN=C(N)N)CCC(=O)N)C(C)C)C(=O)O)[C@H](O)C | 9287217 | ||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Similar- ity |
Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
Assay Type |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 72548703 | 317107 | 0 | None | None | None | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | |||
| CHEMBL4128926 | 317107 | 0 | None | None | None | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 583 | 8 | 3 | 6 | 5.8 | CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 | 10.1016/j.bmcl.2018.03.093 | |||
| 25109291 | 366002 | 9 | None | None | None | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 327 | 1 | 2 | 6 | 1.7 | Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 | 10.1021/jm8007618 | |||
| CHEMBL519240 | 366002 | 9 | None | None | None | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 327 | 1 | 2 | 6 | 1.7 | Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 | 10.1021/jm8007618 | |||
| 59278286 | 336088 | 1 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 453 | 6 | 1 | 7 | 3.2 | CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 | 10.1016/j.bmcl.2018.12.024 | |||
| CHEMBL4464625 | 336088 | 1 | None | None | None | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 453 | 6 | 1 | 7 | 3.2 | CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 | 10.1016/j.bmcl.2018.12.024 | |||
| 11744314 | 178226 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 446 | 6 | 3 | 6 | 3.2 | CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2332935 | 178226 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 446 | 6 | 3 | 6 | 3.2 | CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.04.047 | |||
| 68959963 | 178224 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 432 | 6 | 2 | 5 | 3.1 | CC(=O)Nc1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| CHEMBL2332933 | 178224 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 432 | 6 | 2 | 5 | 3.1 | CC(=O)Nc1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| 11744314 | 178226 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 446 | 6 | 3 | 6 | 3.2 | CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| CHEMBL2332935 | 178226 | 0 | None | None | None | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 446 | 6 | 3 | 6 | 3.2 | CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| 10094212 | 178227 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 430 | 6 | 3 | 6 | 2.7 | CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2332936 | 178227 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 430 | 6 | 3 | 6 | 2.7 | CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | 10.1016/j.bmcl.2013.04.047 | |||
| 10094212 | 178227 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 430 | 6 | 3 | 6 | 2.7 | CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| CHEMBL2332936 | 178227 | 0 | None | None | None | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 430 | 6 | 3 | 6 | 2.7 | CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| 72945512 | 214044 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 471 | 7 | 4 | 6 | 3.0 | O=C(Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2)NC1CC1 | 10.1016/j.bmcl.2013.11.062 | |||
| CHEMBL3099947 | 214044 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 471 | 7 | 4 | 6 | 3.0 | O=C(Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2)NC1CC1 | 10.1016/j.bmcl.2013.11.062 | |||
| 10478859 | 178222 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 448 | 6 | 2 | 5 | 3.6 | CC(=O)Nc1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| CHEMBL2332931 | 178222 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 448 | 6 | 2 | 5 | 3.6 | CC(=O)Nc1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| 25141109 | 258188 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 493 | 5 | 4 | 4 | 3.8 | C[C@H](NC(=O)N[C@@H]1CCCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)(C)O | nan | |||
| CHEMBL3679659 | 258188 | 0 | None | None | None | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 493 | 5 | 4 | 4 | 3.8 | C[C@H](NC(=O)N[C@@H]1CCCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)(C)O | nan | |||
| 71570633 | 178231 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 445 | 6 | 3 | 6 | 3.2 | CC(=O)Nc1ccc(O)cc1OC[C@@H](N)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| CHEMBL2332940 | 178231 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 445 | 6 | 3 | 6 | 3.2 | CC(=O)Nc1ccc(O)cc1OC[C@@H](N)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| 21070989 | 177765 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322875 | 177765 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 57889003 | 181969 | 9 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889430 | 181969 | 9 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398726 | 181969 | 9 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398728 | 181969 | 9 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57888919 | 181970 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889974 | 181970 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398727 | 181970 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398729 | 181970 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 72945510 | 214042 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 487 | 7 | 4 | 6 | 3.5 | O=C(Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)NC1CC1 | 10.1016/j.bmcl.2013.11.062 | |||
| CHEMBL3099945 | 214042 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 487 | 7 | 4 | 6 | 3.5 | O=C(Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)NC1CC1 | 10.1016/j.bmcl.2013.11.062 | |||
| 6918497 | 232475 | 1 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1016/s0960-894x(03)00748-0 | |||
| CHEMBL331897 | 232475 | 1 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1016/s0960-894x(03)00748-0 | |||
| 6918497 | 232475 | 1 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1016/s0960-894x(01)00176-7 | |||
| CHEMBL331897 | 232475 | 1 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1016/s0960-894x(01)00176-7 | |||
| 10389562 | 178221 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 460 | 7 | 2 | 6 | 3.5 | COc1ccc(NC(C)=O)c(OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)c1 | 10.1016/j.bmcl.2012.12.095 | |||
| CHEMBL2332930 | 178221 | 0 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 460 | 7 | 2 | 6 | 3.5 | COc1ccc(NC(C)=O)c(OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)c1 | 10.1016/j.bmcl.2012.12.095 | |||
| 6918497 | 232475 | 1 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL331897 | 232475 | 1 | None | None | None | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | |||
| 10032207 | 181601 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 536 | 6 | 3 | 7 | 3.1 | O=C(c1cc(Cl)c(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@H](O)C1 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391803 | 181601 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 536 | 6 | 3 | 7 | 3.1 | O=C(c1cc(Cl)c(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@H](O)C1 | 10.1016/j.bmcl.2013.04.047 | |||
| 9954423 | 178223 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 430 | 6 | 2 | 5 | 3.5 | CC(=O)Nc1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| CHEMBL2332932 | 178223 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 430 | 6 | 2 | 5 | 3.5 | CC(=O)Nc1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| 10409538 | 178225 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 414 | 6 | 2 | 5 | 3.0 | CC(=O)Nc1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| CHEMBL2332934 | 178225 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 414 | 6 | 2 | 5 | 3.0 | CC(=O)Nc1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| 57889003 | 181969 | 9 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889430 | 181969 | 9 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398726 | 181969 | 9 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398728 | 181969 | 9 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889327 | 181961 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 420 | 6 | 2 | 3 | 3.7 | CC(C)[C@@H](NC(=O)CC1CC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398717 | 181961 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 420 | 6 | 2 | 3 | 3.7 | CC(C)[C@@H](NC(=O)CC1CC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 44537841 | 1390 | 22 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 57889181 | 1390 | 22 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 9497 | 1390 | 22 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL2398716 | 1390 | 22 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL3334824 | 1390 | 22 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 57888993 | 233485 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 471 | 6 | 3 | 3 | 4.3 | CC(C)[C@@H](NC(=O)NCc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| CHEMBL3334818 | 233485 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 471 | 6 | 3 | 3 | 4.3 | CC(C)[C@@H](NC(=O)NCc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| 59278286 | 336088 | 1 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 453 | 6 | 1 | 7 | 3.2 | CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 | 10.1016/j.bmcl.2018.12.024 | |||
| CHEMBL4464625 | 336088 | 1 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 453 | 6 | 1 | 7 | 3.2 | CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 | 10.1016/j.bmcl.2018.12.024 | |||
| 25175119 | 258180 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 533 | 5 | 3 | 5 | 3.0 | CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(S(N)(=O)=O)c2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL3679651 | 258180 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | ChEMBL | 533 | 5 | 3 | 5 | 3.0 | CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(S(N)(=O)=O)c2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| 68963686 | 181608 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 516 | 6 | 3 | 7 | 2.9 | O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCC(O)CC1 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391810 | 181608 | 0 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 516 | 6 | 3 | 7 | 2.9 | O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCC(O)CC1 | 10.1016/j.bmcl.2013.04.047 | |||
| 512282 | 1562 | 44 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2018.11.015 | |||
| 767 | 1562 | 44 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2018.11.015 | |||
| CHEMBL232656 | 1562 | 44 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2018.11.015 | |||
| 57889003 | 181969 | 9 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889430 | 181969 | 9 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398726 | 181969 | 9 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398728 | 181969 | 9 | None | None | None | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57888834 | 181985 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 436 | 7 | 2 | 3 | 4.4 | CC(C)CCC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398744 | 181985 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 436 | 7 | 2 | 3 | 4.4 | CC(C)CCC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| 57889764 | 182007 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 457 | 6 | 2 | 4 | 3.6 | CC(C)[C@@H](NC(=O)Cc1ccncc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398769 | 182007 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 457 | 6 | 2 | 4 | 3.6 | CC(C)[C@@H](NC(=O)Cc1ccncc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 6918497 | 232475 | 1 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1016/j.ejmech.2020.113085 | |||
| CHEMBL331897 | 232475 | 1 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1016/j.ejmech.2020.113085 | |||
| 6918497 | 232475 | 1 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL331897 | 232475 | 1 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | |||
| 71655299 | 181595 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 529 | 7 | 2 | 7 | 3.0 | CN(C)[C@@H]1CCN(C(=O)c2ccc(O)cc2OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)C1 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391797 | 181595 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 529 | 7 | 2 | 7 | 3.0 | CN(C)[C@@H]1CCN(C(=O)c2ccc(O)cc2OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)C1 | 10.1016/j.bmcl.2013.04.047 | |||
| 72945311 | 214039 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 461 | 6 | 4 | 6 | 3.0 | CNC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.11.062 | |||
| CHEMBL3099942 | 214039 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 461 | 6 | 4 | 6 | 3.0 | CNC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.11.062 | |||
| 25175289 | 258184 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 446 | 4 | 2 | 3 | 4.3 | CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)C2CCCC2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL3679655 | 258184 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 446 | 4 | 2 | 3 | 4.3 | CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)C2CCCC2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| 10367570 | 181593 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 472 | 7 | 3 | 6 | 3.1 | O=C(NC1CC1)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391795 | 181593 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 472 | 7 | 3 | 6 | 3.1 | O=C(NC1CC1)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.04.047 | |||
| 10412648 | 181632 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 474 | 7 | 2 | 5 | 3.6 | O=C(NC1CC1)c1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391939 | 181632 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 474 | 7 | 2 | 5 | 3.6 | O=C(NC1CC1)c1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.04.047 | |||
| 57889423 | 181988 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 434 | 5 | 2 | 3 | 4.1 | CC(C)[C@@H](NC(=O)C1CCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398747 | 181988 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 434 | 5 | 2 | 3 | 4.1 | CC(C)[C@@H](NC(=O)C1CCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 68959770 | 214037 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.2 | O=C(Nc1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCCC1 | 10.1016/j.bmcl.2013.11.062 | |||
| CHEMBL3099940 | 214037 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 485 | 6 | 2 | 5 | 4.2 | O=C(Nc1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCCC1 | 10.1016/j.bmcl.2013.11.062 | |||
| 42602331 | 178232 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 429 | 6 | 3 | 6 | 2.7 | CC(=O)Nc1ccc(O)cc1OC[C@@H](N)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| CHEMBL2332941 | 178232 | 0 | None | None | None | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 429 | 6 | 3 | 6 | 2.7 | CC(=O)Nc1ccc(O)cc1OC[C@@H](N)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| 21070989 | 177765 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322875 | 177765 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 44537841 | 1390 | 22 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1016/j.bmcl.2018.11.015 | |||
| 57889181 | 1390 | 22 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1016/j.bmcl.2018.11.015 | |||
| 9497 | 1390 | 22 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1016/j.bmcl.2018.11.015 | |||
| CHEMBL2398716 | 1390 | 22 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1016/j.bmcl.2018.11.015 | |||
| CHEMBL3334824 | 1390 | 22 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1016/j.bmcl.2018.11.015 | |||
| 25141158 | 350212 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 471 | 5 | 2 | 4 | 4.4 | Cc1cc(C)c(C(=O)NC(C)(C)CC(=O)N2CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C2)cn1 | nan | |||
| CHEMBL4594791 | 350212 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 471 | 5 | 2 | 4 | 4.4 | Cc1cc(C)c(C(=O)NC(C)(C)CC(=O)N2CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C2)cn1 | nan | |||
| 25175123 | 258182 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 462 | 4 | 3 | 4 | 3.2 | CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)[C@H]2CC[C@@H](O)C2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL3679653 | 258182 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 462 | 4 | 3 | 4 | 3.2 | CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)[C@H]2CC[C@@H](O)C2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| 57889003 | 181969 | 9 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889430 | 181969 | 9 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398726 | 181969 | 9 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398728 | 181969 | 9 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 25175288 | 258183 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 498 | 5 | 3 | 4 | 4.1 | CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(C(=O)O)c2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL3679654 | 258183 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 498 | 5 | 3 | 4 | 4.1 | CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(C(=O)O)c2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| 57889230 | 181980 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 484 | 8 | 2 | 3 | 5.0 | CC(C)[C@@H](NC(=O)CCCc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398739 | 181980 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 484 | 8 | 2 | 3 | 5.0 | CC(C)[C@@H](NC(=O)CCCc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57888834 | 181985 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 436 | 7 | 2 | 3 | 4.4 | CC(C)CCC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398744 | 181985 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 436 | 7 | 2 | 3 | 4.4 | CC(C)CCC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| 25206951 | 349344 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 434 | 5 | 2 | 3 | 4.3 | CC(C)(CC(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)NC(=O)C1CCCC1 | nan | |||
| CHEMBL4574123 | 349344 | 0 | None | None | None | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 434 | 5 | 2 | 3 | 4.3 | CC(C)(CC(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)NC(=O)C1CCCC1 | nan | |||
| 42602328 | 181591 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 446 | 6 | 3 | 6 | 2.6 | CNC(=O)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391793 | 181591 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 446 | 6 | 3 | 6 | 2.6 | CNC(=O)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.04.047 | |||
| 10368175 | 181606 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 486 | 6 | 2 | 6 | 3.5 | O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCCC1 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391808 | 181606 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 486 | 6 | 2 | 6 | 3.5 | O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCCC1 | 10.1016/j.bmcl.2013.04.047 | |||
| 66686405 | 346689 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 532 | 5 | 2 | 5 | 6.3 | CC(C)(O)c1ccc2c(c1)/C(=C\CCN1CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C1)c1cccnc1CO2 | 10.1016/j.bmcl.2018.11.015 | |||
| CHEMBL4571977 | 346689 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 532 | 5 | 2 | 5 | 6.3 | CC(C)(O)c1ccc2c(c1)/C(=C\CCN1CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C1)c1cccnc1CO2 | 10.1016/j.bmcl.2018.11.015 | |||
| 57889897 | 181978 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 456 | 6 | 2 | 3 | 4.2 | CC(C)[C@@H](NC(=O)Cc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398737 | 181978 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 456 | 6 | 2 | 3 | 4.2 | CC(C)[C@@H](NC(=O)Cc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889071 | 181987 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 420 | 5 | 2 | 3 | 3.7 | CC(C)[C@@H](NC(=O)C1CCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398746 | 181987 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 420 | 5 | 2 | 3 | 3.7 | CC(C)[C@@H](NC(=O)C1CCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 59444283 | 336906 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 485 | 6 | 3 | 4 | 3.5 | CC(C)(CC(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)NC(=O)c1cccc(C(N)=O)c1 | nan | |||
| CHEMBL4476397 | 336906 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 485 | 6 | 3 | 4 | 3.5 | CC(C)(CC(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)NC(=O)c1cccc(C(N)=O)c1 | nan | |||
| 72945313 | 214040 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 521 | 7 | 4 | 6 | 4.2 | O=C(Nc1cc(Cl)c(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)NC1CC1 | 10.1016/j.bmcl.2013.11.062 | |||
| CHEMBL3099943 | 214040 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 521 | 7 | 4 | 6 | 4.2 | O=C(Nc1cc(Cl)c(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)NC1CC1 | 10.1016/j.bmcl.2013.11.062 | |||
| 72945314 | 214041 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 501 | 8 | 3 | 6 | 3.8 | COc1ccc(NC(=O)NC2CC2)c(OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)c1 | 10.1016/j.bmcl.2013.11.062 | |||
| CHEMBL3099944 | 214041 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 501 | 8 | 3 | 6 | 3.8 | COc1ccc(NC(=O)NC2CC2)c(OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)c1 | 10.1016/j.bmcl.2013.11.062 | |||
| 59474992 | 258185 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 497 | 5 | 3 | 4 | 3.5 | CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(C(N)=O)c2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL3679656 | 258185 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 497 | 5 | 3 | 4 | 3.5 | CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(C(N)=O)c2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| 10436125 | 181602 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 502 | 6 | 3 | 7 | 2.5 | O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@H](O)C1 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391804 | 181602 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 502 | 6 | 3 | 7 | 2.5 | O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@H](O)C1 | 10.1016/j.bmcl.2013.04.047 | |||
| 57889334 | 181984 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 422 | 6 | 2 | 3 | 4.0 | CC(C)CC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398743 | 181984 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 422 | 6 | 2 | 3 | 4.0 | CC(C)CC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| 59444225 | 336208 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 467 | 6 | 4 | 4 | 3.4 | C[C@H](NC(=O)NC(C)(C)CC(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)(C)O | nan | |||
| CHEMBL4466344 | 336208 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 467 | 6 | 4 | 4 | 3.4 | C[C@H](NC(=O)NC(C)(C)CC(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)(C)O | nan | |||
| 11803142 | 26286 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 615 | 5 | 1 | 2 | 7.8 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1183314 | 26286 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 615 | 5 | 1 | 2 | 7.8 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 | 10.1021/jm0004244 | |||
| 57889736 | 233480 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 465 | 5 | 4 | 4 | 3.0 | CC(C)[C@@H](NC(=O)N[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| CHEMBL3334727 | 233480 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 465 | 5 | 4 | 4 | 3.0 | CC(C)[C@@H](NC(=O)N[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| 57889679 | 181999 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 442 | 5 | 2 | 3 | 4.2 | CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398761 | 181999 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 442 | 5 | 2 | 3 | 4.2 | CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57888966 | 182009 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 476 | 5 | 2 | 3 | 4.9 | CC(C)[C@@H](NC(=O)c1cccc(Cl)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398771 | 182009 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 476 | 5 | 2 | 3 | 4.9 | CC(C)[C@@H](NC(=O)c1cccc(Cl)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889613 | 182000 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 432 | 5 | 2 | 3 | 4.3 | CC(C)[C@@H](NC(=O)c1ccc(F)c(O)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398762 | 182000 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 432 | 5 | 2 | 3 | 4.3 | CC(C)[C@@H](NC(=O)c1ccc(F)c(O)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57840192 | 177673 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 460 | 5 | 0 | 7 | 2.3 | COc1cc(N2CCN(C(=O)Cn3nc(S(C)(=O)=O)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2321887 | 177673 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 460 | 5 | 0 | 7 | 2.3 | COc1cc(N2CCN(C(=O)Cn3nc(S(C)(=O)=O)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 57840295 | 177735 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 407 | 4 | 0 | 6 | 2.7 | COc1cc(N2CCN(C(=O)Cn3nc(C#N)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322847 | 177735 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 407 | 4 | 0 | 6 | 2.7 | COc1cc(N2CCN(C(=O)Cn3nc(C#N)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 57840511 | 177757 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 466 | 5 | 1 | 6 | 3.1 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3CO)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322867 | 177757 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 466 | 5 | 1 | 6 | 3.1 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3CO)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 71719855 | 177770 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 484 | 4 | 0 | 5 | 4.5 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(Cl)c1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322880 | 177770 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 484 | 4 | 0 | 5 | 4.5 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(Cl)c1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 17753030 | 177887 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 486 | 7 | 2 | 7 | 2.5 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(N)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL232441 | 177887 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 486 | 7 | 2 | 7 | 2.5 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(N)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 59278314 | 334482 | 29 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 425 | 5 | 1 | 7 | 2.3 | CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1 | 10.1016/j.bmcl.2018.12.024 | |||
| CHEMBL4441094 | 334482 | 29 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 425 | 5 | 1 | 7 | 2.3 | CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1 | 10.1016/j.bmcl.2018.12.024 | |||
| 512282 | 1562 | 44 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1021/acs.jmedchem.6b01309 | |||
| 767 | 1562 | 44 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1021/acs.jmedchem.6b01309 | |||
| CHEMBL232656 | 1562 | 44 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1021/acs.jmedchem.6b01309 | |||
| 512282 | 1562 | 44 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1021/acs.jmedchem.6b01309 | |||
| 767 | 1562 | 44 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1021/acs.jmedchem.6b01309 | |||
| CHEMBL232656 | 1562 | 44 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1021/acs.jmedchem.6b01309 | |||
| 21070993 | 177764 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 434 | 3 | 0 | 4 | 4.2 | Cc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322874 | 177764 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 434 | 3 | 0 | 4 | 4.2 | Cc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 57888715 | 164267 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 426 | 5 | 1 | 2 | 5.1 | Cc1cccc(C(=O)N[C@@H](C(=O)N2CCC(c3ccc(Cl)cc3)CC2)C(C)C)c1C | 10.1021/jm300896d | |||
| CHEMBL2180511 | 164267 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 426 | 5 | 1 | 2 | 5.1 | Cc1cccc(C(=O)N[C@@H](C(=O)N2CCC(c3ccc(Cl)cc3)CC2)C(C)C)c1C | 10.1021/jm300896d | |||
| 44430755 | 309540 | 0 | None | None | None | Mouse | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 577 | 10 | 2 | 8 | 3.9 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL397910 | 309540 | 0 | None | None | None | Mouse | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 577 | 10 | 2 | 8 | 3.9 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 44453527 | 197842 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 477 | 4 | 0 | 4 | 4.7 | N#CC1(c2ccc(Cl)cc2)CCN(C2CCN(S(=O)(=O)c3ccccc3Cl)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL270563 | 197842 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 477 | 4 | 0 | 4 | 4.7 | N#CC1(c2ccc(Cl)cc2)CCN(C2CCN(S(=O)(=O)c3ccccc3Cl)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 5481702 | 470631 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 556 | 8 | 0 | 4 | 5.3 | CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1 | 10.1016/s0960-894x(00)00639-9 | |||
| CHEMBL83338 | 470631 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 556 | 8 | 0 | 4 | 5.3 | CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1 | 10.1016/s0960-894x(00)00639-9 | |||
| 11329244 | 143347 | 6 | None | None | None | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 486 | 7 | 2 | 5 | 5.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1021/jm049530m | |||
| CHEMBL195433 | 143347 | 6 | None | None | None | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 486 | 7 | 2 | 5 | 5.4 | CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C | 10.1021/jm049530m | |||
| 11272103 | 252399 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | |||
| CHEMBL363840 | 252399 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 505 | 7 | 2 | 6 | 4.7 | Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 | 10.1021/jm049530m | |||
| 14338 | 18716 | 77 | None | None | None | Human | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccnc(-c2cc(C)ccn2)c1 | 10.1021/jm301121j | |||
| CHEMBL101165 | 18716 | 77 | None | None | None | Human | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 184 | 1 | 0 | 2 | 2.8 | Cc1ccnc(-c2cc(C)ccn2)c1 | 10.1021/jm301121j | |||
| 72792 | 433102 | 57 | None | None | None | Human | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccnc2c1ccc1c(C)ccnc12 | 10.1021/jm301121j | |||
| CHEMBL593442 | 433102 | 57 | None | None | None | Human | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccnc2c1ccc1c(C)ccnc12 | 10.1021/jm301121j | |||
| DB02586 | 433102 | 57 | None | None | None | Human | 4.0 | pIC50 | = | 4 | Binding | ChEMBL | 208 | 0 | 0 | 2 | 3.4 | Cc1ccnc2c1ccc1c(C)ccnc12 | 10.1021/jm301121j | |||
| 44309060 | 203039 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 446 | 10 | 3 | 3 | 4.3 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL306683 | 203039 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 446 | 10 | 3 | 3 | 4.3 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2004.02.021 | |||
| 57889664 | 164221 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 1 | 2 | 5.1 | Cc1ccc(CCC(=O)N[C@@H](C(=O)N2CCC(c3ccc(Cl)cc3)CC2)C(C)C)cc1 | 10.1021/jm300896d | |||
| CHEMBL2180194 | 164221 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 7 | 1 | 2 | 5.1 | Cc1ccc(CCC(=O)N[C@@H](C(=O)N2CCC(c3ccc(Cl)cc3)CC2)C(C)C)cc1 | 10.1021/jm300896d | |||
| 25175449 | 258170 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 526 | 4 | 2 | 5 | 4.1 | CC1(C)CN(C(=O)[C@H]2CC3(CC[C@H]2NC(=O)c2ccccc2)OCCO3)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL3679640 | 258170 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 526 | 4 | 2 | 5 | 4.1 | CC1(C)CN(C(=O)[C@H]2CC3(CC[C@H]2NC(=O)c2ccccc2)OCCO3)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| 57888707 | 182006 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 413 | 6 | 1 | 3 | 3.8 | CC(C)[C@@H](NC(=O)Cc1ccncc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398768 | 182006 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 413 | 6 | 1 | 3 | 3.8 | CC(C)[C@@H](NC(=O)Cc1ccncc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| 71718646 | 177768 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 464 | 4 | 0 | 5 | 4.2 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(C)c1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322878 | 177768 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 464 | 4 | 0 | 5 | 4.2 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(C)c1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 57888718 | 164272 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 428 | 6 | 1 | 3 | 5.0 | CC(C)C(NC(=O)OCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180518 | 164272 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 428 | 6 | 1 | 3 | 5.0 | CC(C)C(NC(=O)OCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 71719253 | 177743 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 480 | 5 | 1 | 6 | 3.2 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)[C@H](CO)C2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322854 | 177743 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 480 | 5 | 1 | 6 | 3.2 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)[C@H](CO)C2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 25233756 | 354749 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 467 | 4 | 1 | 2 | 5.6 | Cc1cc(C(F)(F)F)cc(C)c1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1 | 10.1021/jm801416q | |||
| CHEMBL475748 | 354749 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 467 | 4 | 1 | 2 | 5.6 | Cc1cc(C(F)(F)F)cc(C)c1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1 | 10.1021/jm801416q | |||
| 118714034 | 233487 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 424 | 6 | 3 | 4 | 2.7 | CC(C)[C@@H](NC(=O)C[C@H](C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| CHEMBL3334820 | 233487 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 424 | 6 | 3 | 4 | 2.7 | CC(C)[C@@H](NC(=O)C[C@H](C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| 59474993 | 258186 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 503 | 5 | 3 | 4 | 4.4 | [C-]#[N+]c1ccc([C@@]2(O)CCN(C(=O)[C@H]3CCCC[C@H]3NC(=O)c3cccc(C(=O)O)c3)CC2(C)C)cc1 | nan | |||
| CHEMBL3679657 | 258186 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 503 | 5 | 3 | 4 | 4.4 | [C-]#[N+]c1ccc([C@@]2(O)CCN(C(=O)[C@H]3CCCC[C@H]3NC(=O)c3cccc(C(=O)O)c3)CC2(C)C)cc1 | nan | |||
| 25175448 | 258168 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 469 | 4 | 3 | 3 | 4.8 | CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)Nc2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL3679639 | 258168 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 469 | 4 | 3 | 3 | 4.8 | CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)Nc2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| 71655559 | 181603 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 529 | 7 | 2 | 7 | 3.0 | CN(C)[C@H]1CCN(C(=O)c2ccc(O)cc2OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)C1 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391805 | 181603 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 529 | 7 | 2 | 7 | 3.0 | CN(C)[C@H]1CCN(C(=O)c2ccc(O)cc2OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)C1 | 10.1016/j.bmcl.2013.04.047 | |||
| 44453291 | 197729 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 442 | 7 | 2 | 4 | 3.6 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Cl | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL269957 | 197729 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 442 | 7 | 2 | 4 | 3.6 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Cl | 10.1016/j.bmcl.2007.09.068 | |||
| 21071070 | 177755 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 478 | 5 | 0 | 5 | 4.7 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C(C)C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322865 | 177755 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 478 | 5 | 0 | 5 | 4.7 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C(C)C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 10811980 | 200129 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 418 | 6 | 1 | 2 | 5.8 | O=C(NC1CCN(CC2CCCCCCC2)CC1)C(c1ccccc1)c1ccccc1 | 10.1021/jm0004244 | |||
| CHEMBL286355 | 200129 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 418 | 6 | 1 | 2 | 5.8 | O=C(NC1CCN(CC2CCCCCCC2)CC1)C(c1ccccc1)c1ccccc1 | 10.1021/jm0004244 | |||
| 21071081 | 177763 | 1 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 420 | 3 | 0 | 4 | 3.9 | Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2cccc(Cl)c2)CC1 | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322873 | 177763 | 1 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 420 | 3 | 0 | 4 | 3.9 | Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2cccc(Cl)c2)CC1 | 10.1016/j.bmcl.2013.01.005 | |||
| 44453227 | 195768 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 548 | 4 | 1 | 4 | 4.5 | O=S(=O)(c1c(F)cc(F)cc1Br)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL256887 | 195768 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 548 | 4 | 1 | 4 | 4.5 | O=S(=O)(c1c(F)cc(F)cc1Br)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 57888832 | 164215 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 446 | 6 | 1 | 2 | 5.1 | CC(C)[C@@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180188 | 164215 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 446 | 6 | 1 | 2 | 5.1 | CC(C)[C@@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 44453436 | 197950 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 458 | 7 | 2 | 4 | 4.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL271079 | 197950 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 458 | 7 | 2 | 4 | 4.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2007.09.068 | |||
| 44453525 | 197806 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 452 | 4 | 1 | 4 | 3.6 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL270358 | 197806 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 452 | 4 | 1 | 4 | 3.6 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 24758046 | 164263 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 416 | 5 | 1 | 2 | 4.6 | CC(C)[C@@H](NC(=O)c1ccc(F)cc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180507 | 164263 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 416 | 5 | 1 | 2 | 4.6 | CC(C)[C@@H](NC(=O)c1ccc(F)cc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 12015739 | 213342 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 413 | 10 | 3 | 4 | 3.5 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](CC(C)C)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.020 | |||
| CHEMBL308690 | 213342 | 0 | None | None | None | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 413 | 10 | 3 | 4 | 3.5 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](CC(C)C)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.020 | |||
| 59444213 | 335839 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 484 | 5 | 2 | 4 | 4.2 | CC1(C)CN(C(=O)CC2(NC(=O)c3ccccc3)CCOCC2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL4460796 | 335839 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 484 | 5 | 2 | 4 | 4.2 | CC1(C)CN(C(=O)CC2(NC(=O)c3ccccc3)CCOCC2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| 59444196 | 349306 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 442 | 5 | 2 | 3 | 4.2 | CC(NC(=O)c1ccccc1)C(C)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | nan | |||
| CHEMBL4573109 | 349306 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 442 | 5 | 2 | 3 | 4.2 | CC(NC(=O)c1ccccc1)C(C)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | nan | |||
| 68963562 | 181600 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 488 | 6 | 2 | 6 | 2.4 | O=C(c1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2)N1CC[C@H](O)C1 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391802 | 181600 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 488 | 6 | 2 | 6 | 2.4 | O=C(c1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2)N1CC[C@H](O)C1 | 10.1016/j.bmcl.2013.04.047 | |||
| 10073725 | 181610 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 476 | 8 | 4 | 7 | 2.0 | O=C(NCCO)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391812 | 181610 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 476 | 8 | 4 | 7 | 2.0 | O=C(NCCO)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.04.047 | |||
| 57888919 | 181970 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889974 | 181970 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398727 | 181970 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398729 | 181970 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 21070989 | 177765 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322875 | 177765 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 21070983 | 177766 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 464 | 5 | 0 | 5 | 4.3 | CCOc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322876 | 177766 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 464 | 5 | 0 | 5 | 4.3 | CCOc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 71718022 | 177776 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 480 | 5 | 1 | 6 | 3.4 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(CO)c1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322886 | 177776 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 480 | 5 | 1 | 6 | 3.4 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(CO)c1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 44430752 | 178860 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 599 | 11 | 2 | 9 | 2.7 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL234295 | 178860 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 599 | 11 | 2 | 9 | 2.7 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 11803142 | 26286 | 0 | None | None | None | Mouse | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 615 | 5 | 1 | 2 | 7.8 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1183314 | 26286 | 0 | None | None | None | Mouse | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 615 | 5 | 1 | 2 | 7.8 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 | 10.1021/jm0004244 | |||
| 6918497 | 232475 | 1 | None | None | None | Mouse | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL331897 | 232475 | 1 | None | None | None | Mouse | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | |||
| 25175446 | 258167 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 450 | 3 | 2 | 4 | 4.5 | CC(C)(C)OC(=O)N[C@@H]1CCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | nan | |||
| CHEMBL3679638 | 258167 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 450 | 3 | 2 | 4 | 4.5 | CC(C)(C)OC(=O)N[C@@H]1CCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | nan | |||
| 71560163 | 177739 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 411 | 5 | 1 | 6 | 2.3 | COc1cc(N2CCN(C(=O)Cn3nc(CN)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322850 | 177739 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 411 | 5 | 1 | 6 | 2.3 | COc1cc(N2CCN(C(=O)Cn3nc(CN)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 57840312 | 177761 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 382 | 4 | 0 | 5 | 2.9 | COc1cc(N2CCN(C(=O)Cn3ncc(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322871 | 177761 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 382 | 4 | 0 | 5 | 2.9 | COc1cc(N2CCN(C(=O)Cn3ncc(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 25233754 | 353229 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 473 | 4 | 1 | 2 | 5.7 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1Cl | 10.1021/jm801416q | |||
| CHEMBL473531 | 353229 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 473 | 4 | 1 | 2 | 5.7 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1Cl | 10.1021/jm801416q | |||
| 57889591 | 164290 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 398 | 6 | 1 | 2 | 4.6 | CCCC(NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180538 | 164290 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 398 | 6 | 1 | 2 | 4.6 | CCCC(NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 155549724 | 347937 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 427 | 4 | 1 | 3 | 5.4 | Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2018.11.015 | |||
| CHEMBL4539264 | 347937 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 427 | 4 | 1 | 3 | 5.4 | Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2018.11.015 | |||
| 24758630 | 164250 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 438 | 5 | 1 | 2 | 5.4 | O=C(N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C1CCCCC1)c1ccccc1 | 10.1021/jm300896d | |||
| CHEMBL2180494 | 164250 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 438 | 5 | 1 | 2 | 5.4 | O=C(N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C1CCCCC1)c1ccccc1 | 10.1021/jm300896d | |||
| 57889696 | 164281 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 384 | 5 | 1 | 2 | 4.3 | CC[C@@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180527 | 164281 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 384 | 5 | 1 | 2 | 4.3 | CC[C@@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 57888938 | 182004 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 477 | 6 | 2 | 4 | 3.1 | CC(C)[C@@H](NC(=O)c1cccc(S(N)(=O)=O)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398766 | 182004 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 477 | 6 | 2 | 4 | 3.1 | CC(C)[C@@H](NC(=O)c1cccc(S(N)(=O)=O)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| 11124782 | 237268 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 587 | 11 | 3 | 3 | 7.3 | O=C(NCC1CCCCC1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | |||
| CHEMBL341306 | 237268 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 587 | 11 | 3 | 3 | 7.3 | O=C(NCC1CCCCC1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | |||
| 44453357 | 197826 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 434 | 4 | 1 | 4 | 3.5 | O=S(=O)(c1ccccc1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL270419 | 197826 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 434 | 4 | 1 | 4 | 3.5 | O=S(=O)(c1ccccc1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 57889164 | 182001 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 476 | 5 | 3 | 4 | 4.1 | CC(C)[C@@H](NC(=O)c1ccc(F)c(O)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398763 | 182001 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 476 | 5 | 3 | 4 | 4.1 | CC(C)[C@@H](NC(=O)c1ccc(F)c(O)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 44431529 | 178851 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 490 | 9 | 1 | 5 | 4.0 | C[C@H]1CN(C(=O)COc2ccc(Cl)cc2C(=O)CCC(=O)O)[C@H](C)CN1Cc1ccc(F)cc1 | 10.1016/j.bmcl.2007.03.037 | |||
| CHEMBL234263 | 178851 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 490 | 9 | 1 | 5 | 4.0 | C[C@H]1CN(C(=O)COc2ccc(Cl)cc2C(=O)CCC(=O)O)[C@H](C)CN1Cc1ccc(F)cc1 | 10.1016/j.bmcl.2007.03.037 | |||
| 57889660 | 181981 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 380 | 4 | 2 | 3 | 2.9 | CC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398740 | 181981 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 380 | 4 | 2 | 3 | 2.9 | CC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| 21070989 | 177765 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322875 | 177765 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 24758296 | 164213 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 430 | 6 | 1 | 2 | 4.6 | CC(C)[C@@H](NC(=O)Cc1ccccc1F)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180186 | 164213 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 430 | 6 | 1 | 2 | 4.6 | CC(C)[C@@H](NC(=O)Cc1ccccc1F)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 72945111 | 214057 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 459 | 7 | 3 | 6 | 2.8 | CNC(=O)Nc1ccc(OC)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | 10.1016/j.bmcl.2013.11.062 | |||
| CHEMBL3099960 | 214057 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 459 | 7 | 3 | 6 | 2.8 | CNC(=O)Nc1ccc(OC)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | 10.1016/j.bmcl.2013.11.062 | |||
| 68958915 | 181599 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 470 | 6 | 2 | 6 | 2.2 | O=C(c1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1ccccc1O2)N1CC[C@H](O)C1 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391801 | 181599 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 470 | 6 | 2 | 6 | 2.2 | O=C(c1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1ccccc1O2)N1CC[C@H](O)C1 | 10.1016/j.bmcl.2013.04.047 | |||
| 57888652 | 164291 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 412 | 6 | 1 | 2 | 4.9 | CC(C)CC(NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180539 | 164291 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 412 | 6 | 1 | 2 | 4.9 | CC(C)CC(NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 44309267 | 469006 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 447 | 10 | 3 | 4 | 3.7 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1ccc2ccccc2n1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL69978 | 469006 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 447 | 10 | 3 | 4 | 3.7 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1ccc2ccccc2n1 | 10.1016/j.bmcl.2004.02.021 | |||
| 25231480 | 373172 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 389 | 4 | 1 | 2 | 4.1 | CN(Cc1ccc(F)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 | 10.1021/jm801416q | |||
| CHEMBL517261 | 373172 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 389 | 4 | 1 | 2 | 4.1 | CN(Cc1ccc(F)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 | 10.1021/jm801416q | |||
| 72947880 | 214053 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 445 | 5 | 2 | 7 | 3.7 | Nc1nc2c(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)cccc2s1 | 10.1016/j.bmcl.2013.11.062 | |||
| CHEMBL3099956 | 214053 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 445 | 5 | 2 | 7 | 3.7 | Nc1nc2c(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)cccc2s1 | 10.1016/j.bmcl.2013.11.062 | |||
| 69437067 | 214054 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 444 | 5 | 1 | 6 | 4.5 | Cc1nc2c(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)cccc2s1 | 10.1016/j.bmcl.2013.11.062 | |||
| CHEMBL3099957 | 214054 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 444 | 5 | 1 | 6 | 4.5 | Cc1nc2c(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)cccc2s1 | 10.1016/j.bmcl.2013.11.062 | |||
| 10628025 | 25453 | 0 | None | None | None | Mouse | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 523 | 6 | 1 | 2 | 7.6 | O=C(NC1CC[N+](Cc2ccccc2)(CC2CCCCCCC2)CC1)C1c2ccccc2Oc2ccccc21 | 10.1021/jm0004244 | |||
| CHEMBL1178588 | 25453 | 0 | None | None | None | Mouse | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 523 | 6 | 1 | 2 | 7.6 | O=C(NC1CC[N+](Cc2ccccc2)(CC2CCCCCCC2)CC1)C1c2ccccc2Oc2ccccc21 | 10.1021/jm0004244 | |||
| 44453464 | 195673 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 488 | 4 | 1 | 4 | 3.9 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3cc(F)c(F)c(F)c3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL256449 | 195673 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 488 | 4 | 1 | 4 | 3.9 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3cc(F)c(F)c(F)c3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 11082578 | 236898 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 603 | 10 | 3 | 3 | 7.5 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1cc(F)ccc1F | 10.1021/jm0201767 | |||
| CHEMBL340491 | 236898 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 603 | 10 | 3 | 3 | 7.5 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1cc(F)ccc1F | 10.1021/jm0201767 | |||
| 71719254 | 177771 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 528 | 4 | 0 | 5 | 4.6 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(Br)c1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322881 | 177771 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 528 | 4 | 0 | 5 | 4.6 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(Br)c1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 24758297 | 164264 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 434 | 5 | 1 | 2 | 4.8 | CC(C)[C@@H](NC(=O)c1ccc(F)c(F)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180508 | 164264 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 434 | 5 | 1 | 2 | 4.8 | CC(C)[C@@H](NC(=O)c1ccc(F)c(F)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 10769447 | 25459 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 447 | 4 | 1 | 2 | 6.0 | C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1016/j.ejmech.2020.113085 | |||
| CHEMBL1178601 | 25459 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 447 | 4 | 1 | 2 | 6.0 | C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1016/j.ejmech.2020.113085 | |||
| 10769447 | 25459 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 447 | 4 | 1 | 2 | 6.0 | C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1178601 | 25459 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 447 | 4 | 1 | 2 | 6.0 | C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| 25175122 | 258181 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 462 | 4 | 3 | 4 | 3.2 | CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)[C@@H]2CC[C@H](O)C2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL3679652 | 258181 | 0 | None | None | None | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 462 | 4 | 3 | 4 | 3.2 | CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)[C@@H]2CC[C@H](O)C2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| 44537841 | 1390 | 22 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 57889181 | 1390 | 22 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 9497 | 1390 | 22 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL2398716 | 1390 | 22 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL3334824 | 1390 | 22 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 25174956 | 258179 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 465 | 5 | 4 | 4 | 3.0 | C[C@@H](O)CNC(=O)N[C@@H]1CCCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | nan | |||
| CHEMBL3679650 | 258179 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 465 | 5 | 4 | 4 | 3.0 | C[C@@H](O)CNC(=O)N[C@@H]1CCCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | nan | |||
| 24782826 | 372710 | 4 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 439 | 4 | 1 | 2 | 5.0 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2010.07.082 | |||
| CHEMBL514611 | 372710 | 4 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 439 | 4 | 1 | 2 | 5.0 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2010.07.082 | |||
| 24782826 | 372710 | 4 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 439 | 4 | 1 | 2 | 5.0 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 | 10.1021/jm801416q | |||
| CHEMBL514611 | 372710 | 4 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 439 | 4 | 1 | 2 | 5.0 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 | 10.1021/jm801416q | |||
| 57889255 | 164216 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 426 | 6 | 1 | 2 | 4.7 | Cc1ccc(CC(=O)N[C@@H](C(=O)N2CCC(c3ccc(Cl)cc3)CC2)C(C)C)cc1 | 10.1021/jm300896d | |||
| CHEMBL2180189 | 164216 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 426 | 6 | 1 | 2 | 4.7 | Cc1ccc(CC(=O)N[C@@H](C(=O)N2CCC(c3ccc(Cl)cc3)CC2)C(C)C)cc1 | 10.1021/jm300896d | |||
| 44430726 | 177890 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 502 | 8 | 2 | 7 | 2.6 | CNc1c(Nc2cc(F)c(F)cc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL232455 | 177890 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 502 | 8 | 2 | 7 | 2.6 | CNc1c(Nc2cc(F)c(F)cc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 44453293 | 332188 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 486 | 7 | 2 | 4 | 3.8 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Br | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL429591 | 332188 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 486 | 7 | 2 | 4 | 3.8 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Br | 10.1016/j.bmcl.2007.09.068 | |||
| 10765199 | 222294 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 432 | 4 | 1 | 3 | 5.9 | O=C(NC1CCN(CC2CCCCCCC2)CC1)C1c2ccccc2Oc2ccccc21 | 10.1016/j.ejmech.2020.113085 | |||
| CHEMBL33074 | 222294 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 432 | 4 | 1 | 3 | 5.9 | O=C(NC1CCN(CC2CCCCCCC2)CC1)C1c2ccccc2Oc2ccccc21 | 10.1016/j.ejmech.2020.113085 | |||
| 10765199 | 222294 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 432 | 4 | 1 | 3 | 5.9 | O=C(NC1CCN(CC2CCCCCCC2)CC1)C1c2ccccc2Oc2ccccc21 | 10.1021/jm0004244 | |||
| CHEMBL33074 | 222294 | 0 | None | None | None | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 432 | 4 | 1 | 3 | 5.9 | O=C(NC1CCN(CC2CCCCCCC2)CC1)C1c2ccccc2Oc2ccccc21 | 10.1021/jm0004244 | |||
| 10676520 | 25452 | 0 | None | None | None | Mouse | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 617 | 5 | 1 | 2 | 7.9 | CC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1178581 | 25452 | 0 | None | None | None | Mouse | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 617 | 5 | 1 | 2 | 7.9 | CC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 | 10.1021/jm0004244 | |||
| 10509339 | 26639 | 0 | None | None | None | Mouse | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 631 | 6 | 1 | 2 | 8.3 | CCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1185511 | 26639 | 0 | None | None | None | Mouse | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 631 | 6 | 1 | 2 | 8.3 | CCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 | 10.1021/jm0004244 | |||
| 44453614 | 308735 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 512 | 4 | 1 | 4 | 4.2 | O=S(=O)(c1ccccc1Br)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL402825 | 308735 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 512 | 4 | 1 | 4 | 4.2 | O=S(=O)(c1ccccc1Br)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | |||
| 11814253 | 235826 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 635 | 10 | 3 | 3 | 8.2 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1cccc(C(F)(F)F)c1 | 10.1021/jm0201767 | |||
| CHEMBL338624 | 235826 | 0 | None | None | None | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 635 | 10 | 3 | 3 | 8.2 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1cccc(C(F)(F)F)c1 | 10.1021/jm0201767 | |||
| 24758044 | 164277 | 0 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 57888953 | 164277 | 0 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 71455572 | 164277 | 0 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180523 | 164277 | 0 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180528 | 164277 | 0 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180534 | 164277 | 0 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 21070989 | 177765 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322875 | 177765 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 57889660 | 181981 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 380 | 4 | 2 | 3 | 2.9 | CC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398740 | 181981 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 380 | 4 | 2 | 3 | 2.9 | CC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| 57889158 | 181975 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 443 | 5 | 2 | 4 | 3.6 | CC(C)[C@@H](NC(=O)c1ccccn1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398734 | 181975 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 443 | 5 | 2 | 4 | 3.6 | CC(C)[C@@H](NC(=O)c1ccccn1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 44430754 | 331491 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 577 | 10 | 2 | 8 | 3.9 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2ccccn2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL428193 | 331491 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 577 | 10 | 2 | 8 | 3.9 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2ccccn2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 44309165 | 468964 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 490 | 9 | 3 | 6 | 3.0 | CC1CC([C@H](C[C@H](O)[C@H](Cc2ccccc2)NC(=O)c2cnc3ccccc3n2)C(N)=O)CC(C)O1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL69659 | 468964 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 490 | 9 | 3 | 6 | 3.0 | CC1CC([C@H](C[C@H](O)[C@H](Cc2ccccc2)NC(=O)c2cnc3ccccc3n2)C(N)=O)CC(C)O1 | 10.1016/j.bmcl.2004.02.021 | |||
| 25174462 | 258176 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 496 | 6 | 2 | 3 | 5.1 | CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)CCc2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL3679646 | 258176 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 496 | 6 | 2 | 3 | 5.1 | CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)CCc2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| 44453202 | 195665 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 7 | 2 | 4 | 3.3 | Cc1ccccc1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL256404 | 195665 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 422 | 7 | 2 | 4 | 3.3 | Cc1ccccc1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 10555351 | 235084 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 586 | 4 | 1 | 3 | 7.3 | O=C(NC1CCN(C/C2=C/CCCCCC2)CC1)C1c2cc(Br)ccc2Oc2ccc(Br)cc21 | 10.1021/jm0004244 | |||
| CHEMBL33580 | 235084 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 586 | 4 | 1 | 3 | 7.3 | O=C(NC1CCN(C/C2=C/CCCCCC2)CC1)C1c2cc(Br)ccc2Oc2ccc(Br)cc21 | 10.1021/jm0004244 | |||
| 44309155 | 461770 | 0 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 453 | 10 | 3 | 4 | 4.5 | CNC(=O)[C@@H](CC(C)C)C[C@@H](O)[C@@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.020 | |||
| CHEMBL69822 | 461770 | 0 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 453 | 10 | 3 | 4 | 4.5 | CNC(=O)[C@@H](CC(C)C)C[C@@H](O)[C@@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.020 | |||
| 24758743 | 164278 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 364 | 6 | 1 | 2 | 4.0 | CC[C@@H](NC(=O)CC(C)C)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180524 | 164278 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 364 | 6 | 1 | 2 | 4.0 | CC[C@@H](NC(=O)CC(C)C)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 57888775 | 164293 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 412 | 6 | 1 | 2 | 5.0 | CCCC(NC(=O)c1ccccc1C)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180541 | 164293 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 412 | 6 | 1 | 2 | 5.0 | CCCC(NC(=O)c1ccccc1C)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 57889484 | 182002 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 532 | 7 | 3 | 3 | 5.7 | CC(C)[C@@H](NC(=O)c1cccc(-c2ccccc2NC(N)=O)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398764 | 182002 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 532 | 7 | 3 | 3 | 5.7 | CC(C)[C@@H](NC(=O)c1cccc(-c2ccccc2NC(N)=O)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| 11351191 | 177733 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 440 | 5 | 1 | 6 | 3.1 | COc1cc(N2CCN(C(=O)Cn3nc(C(C)(C)O)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322845 | 177733 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 440 | 5 | 1 | 6 | 3.1 | COc1cc(N2CCN(C(=O)Cn3nc(C(C)(C)O)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 71718023 | 177777 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 479 | 5 | 1 | 6 | 3.3 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(CN)c1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322887 | 177777 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 479 | 5 | 1 | 6 | 3.3 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(CN)c1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 44537841 | 1390 | 22 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 57889181 | 1390 | 22 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 9497 | 1390 | 22 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL2398716 | 1390 | 22 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL3334824 | 1390 | 22 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 69437029 | 214052 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 427 | 5 | 1 | 5 | 4.6 | Cc1cc2c(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)cccc2o1 | 10.1016/j.bmcl.2013.11.062 | |||
| CHEMBL3099955 | 214052 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 427 | 5 | 1 | 5 | 4.6 | Cc1cc2c(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)cccc2o1 | 10.1016/j.bmcl.2013.11.062 | |||
| 44430742 | 279220 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 557 | 11 | 2 | 8 | 2.9 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN(C)C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL387821 | 279220 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 557 | 11 | 2 | 8 | 2.9 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN(C)C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 44430724 | 298656 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 484 | 8 | 2 | 7 | 2.5 | CNc1c(Nc2cc(F)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL396700 | 298656 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 484 | 8 | 2 | 7 | 2.5 | CNc1c(Nc2cc(F)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 44453529 | 198142 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 414 | 7 | 2 | 5 | 3.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccs1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL272097 | 198142 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 414 | 7 | 2 | 5 | 3.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccs1 | 10.1016/j.bmcl.2007.09.068 | |||
| 44309347 | 469197 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 516 | 10 | 3 | 5 | 4.4 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL71242 | 469197 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 516 | 10 | 3 | 5 | 4.4 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.021 | |||
| 10502989 | 232372 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 434 | 6 | 2 | 3 | 4.9 | O=C(NC1CCN(CC2CCCCCCC2)CC1)C(O)(c1ccccc1)c1ccccc1 | 10.1021/jm0004244 | |||
| CHEMBL33159 | 232372 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 434 | 6 | 2 | 3 | 4.9 | O=C(NC1CCN(CC2CCCCCCC2)CC1)C(O)(c1ccccc1)c1ccccc1 | 10.1021/jm0004244 | |||
| 57991685 | 181964 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 449 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@H](N)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398720 | 181964 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 449 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@H](N)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 10875472 | 232694 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 568 | 10 | 3 | 4 | 6.6 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccncc1 | 10.1021/jm0201767 | |||
| CHEMBL332277 | 232694 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 568 | 10 | 3 | 4 | 6.6 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccncc1 | 10.1021/jm0201767 | |||
| 44430753 | 279194 | 0 | None | None | None | Mouse | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 598 | 11 | 3 | 9 | 2.2 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL387608 | 279194 | 0 | None | None | None | Mouse | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 598 | 11 | 3 | 9 | 2.2 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 44309237 | 202875 | 0 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 463 | 10 | 4 | 5 | 3.4 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc2ccccc2nc1O | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL305420 | 202875 | 0 | None | None | None | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 463 | 10 | 4 | 5 | 3.4 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc2ccccc2nc1O | 10.1016/j.bmcl.2004.02.021 | |||
| 71681400 | 181968 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 449 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CCC[C@H]1N)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398725 | 181968 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 449 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CCC[C@H]1N)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 25252974 | 40088 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 449 | 4 | 1 | 4 | 5.4 | O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1nncn1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.07.082 | |||
| CHEMBL1224188 | 40088 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 449 | 4 | 1 | 4 | 5.4 | O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1nncn1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.07.082 | |||
| 10580015 | 25457 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 515 | 4 | 1 | 2 | 7.3 | C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1178597 | 25457 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 515 | 4 | 1 | 2 | 7.3 | C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | |||
| 25175450 | 258171 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 482 | 4 | 2 | 4 | 4.0 | CC1(C)CN(C(=O)[C@H]2CC(=O)CC[C@H]2NC(=O)c2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL3679641 | 258171 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 482 | 4 | 2 | 4 | 4.0 | CC1(C)CN(C(=O)[C@H]2CC(=O)CC[C@H]2NC(=O)c2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| 44430735 | 178812 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 528 | 10 | 2 | 7 | 3.8 | CCCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL234081 | 178812 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 528 | 10 | 2 | 7 | 3.8 | CCCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 57889667 | 164284 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 458 | 5 | 2 | 3 | 3.7 | CC(C)C(NC(=O)c1ccccc1)C(=O)N1CCC(O)(c2ccc(Br)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180531 | 164284 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 458 | 5 | 2 | 3 | 3.7 | CC(C)C(NC(=O)c1ccccc1)C(=O)N1CCC(O)(c2ccc(Br)cc2)CC1 | 10.1021/jm300896d | |||
| 71452035 | 164268 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 426 | 5 | 1 | 2 | 5.1 | Cc1cccc(C)c1C(=O)N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C | 10.1021/jm300896d | |||
| CHEMBL2180512 | 164268 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 426 | 5 | 1 | 2 | 5.1 | Cc1cccc(C)c1C(=O)N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C | 10.1021/jm300896d | |||
| 44430752 | 178860 | 0 | None | None | None | Mouse | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 599 | 11 | 2 | 9 | 2.7 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL234295 | 178860 | 0 | None | None | None | Mouse | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 599 | 11 | 2 | 9 | 2.7 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 24738063 | 181996 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 419 | 5 | 1 | 3 | 4.1 | CC(C)[C@@H](NC(=O)C1CCCC1)C(=O)N1CCN(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398758 | 181996 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 419 | 5 | 1 | 3 | 4.1 | CC(C)[C@@H](NC(=O)C1CCCC1)C(=O)N1CCN(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889679 | 181999 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 442 | 5 | 2 | 3 | 4.2 | CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398761 | 181999 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 442 | 5 | 2 | 3 | 4.2 | CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57840356 | 177753 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 436 | 4 | 0 | 5 | 3.6 | COc1cc(N2CCN(C(=O)Cn3cc(Cl)c(C(F)(F)F)n3)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322863 | 177753 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 436 | 4 | 0 | 5 | 3.6 | COc1cc(N2CCN(C(=O)Cn3cc(Cl)c(C(F)(F)F)n3)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 57889975 | 164219 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 444 | 7 | 1 | 2 | 5.0 | CC(C)[C@@H](NC(=O)CCc1ccccc1F)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180192 | 164219 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 444 | 7 | 1 | 2 | 5.0 | CC(C)[C@@H](NC(=O)CCc1ccccc1F)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 24758298 | 164222 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 455 | 5 | 1 | 4 | 5.1 | CC(C)[C@@H](NC(=O)c1nc2ccccc2s1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180195 | 164222 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 455 | 5 | 1 | 4 | 5.1 | CC(C)[C@@H](NC(=O)c1nc2ccccc2s1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 71570634 | 178233 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 411 | 6 | 3 | 6 | 2.5 | CC(=O)Nc1ccc(O)cc1OC[C@@H](N)CN1CCC2(CC1)Cc1ccccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| CHEMBL2332942 | 178233 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 411 | 6 | 3 | 6 | 2.5 | CC(=O)Nc1ccc(O)cc1OC[C@@H](N)CN1CCC2(CC1)Cc1ccccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| 44430748 | 178095 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 529 | 10 | 3 | 8 | 2.3 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL232837 | 178095 | 0 | None | None | None | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 529 | 10 | 3 | 8 | 2.3 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 25176235 | 258172 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 483 | 4 | 3 | 3 | 5.2 | CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)Nc2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL3679642 | 258172 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 483 | 4 | 3 | 3 | 5.2 | CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)Nc2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| 25174305 | 258174 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 470 | 4 | 2 | 5 | 3.6 | CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)c2cncnc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL3679644 | 258174 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 470 | 4 | 2 | 5 | 3.6 | CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)c2cncnc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| 57889141 | 164275 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 427 | 6 | 2 | 2 | 4.6 | CC(C)[C@@H](NC(=O)NCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180521 | 164275 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 427 | 6 | 2 | 2 | 4.6 | CC(C)[C@@H](NC(=O)NCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 57889796 | 164299 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 414 | 5 | 2 | 3 | 3.6 | CC(C)C(NC(=O)c1ccccc1)C(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180548 | 164299 | 0 | None | None | None | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 414 | 5 | 2 | 3 | 3.6 | CC(C)C(NC(=O)c1ccccc1)C(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 73349030 | 181992 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 476 | 5 | 2 | 3 | 4.9 | CC(C)[C@@H](NC(=O)c1ccc(Cl)cc1)C(=O)N1CC[C@@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398751 | 181992 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 476 | 5 | 2 | 3 | 4.9 | CC(C)[C@@H](NC(=O)c1ccc(Cl)cc1)C(=O)N1CC[C@@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 10555068 | 26282 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 443 | 4 | 1 | 1 | 6.7 | C[N+]1(CC2CCCCCCC2)CCC(NC(=O)c2c3ccccc3cc3ccccc23)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1183306 | 26282 | 0 | None | None | None | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 443 | 4 | 1 | 1 | 6.7 | C[N+]1(CC2CCCCCCC2)CCC(NC(=O)c2c3ccccc3cc3ccccc23)CC1 | 10.1021/jm0004244 | |||
| 21070982 | 177781 | 1 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 464 | 3 | 0 | 4 | 4.0 | Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(Br)cc2)CC1 | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322891 | 177781 | 1 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 464 | 3 | 0 | 4 | 4.0 | Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(Br)cc2)CC1 | 10.1016/j.bmcl.2013.01.005 | |||
| 57889592 | 164285 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 396 | 5 | 1 | 2 | 4.4 | CC(C)C(NC(=O)c1ccccc1)C(=O)N1CC=C(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180532 | 164285 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 396 | 5 | 1 | 2 | 4.4 | CC(C)C(NC(=O)c1ccccc1)C(=O)N1CC=C(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 44453433 | 316434 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL411476 | 316434 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2007.09.068 | |||
| 44309087 | 202469 | 0 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 447 | 10 | 3 | 4 | 3.7 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1ccnc2ccccc12 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL303947 | 202469 | 0 | None | None | None | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | 447 | 10 | 3 | 4 | 3.7 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1ccnc2ccccc12 | 10.1016/j.bmcl.2004.02.021 | |||
| 57889180 | 233479 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 465 | 5 | 4 | 4 | 3.0 | CC(C)[C@@H](NC(=O)N[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| CHEMBL3334726 | 233479 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 465 | 5 | 4 | 4 | 3.0 | CC(C)[C@@H](NC(=O)N[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| 57840556 | 177746 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 416 | 4 | 0 | 5 | 3.2 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)cc3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322857 | 177746 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 416 | 4 | 0 | 5 | 3.2 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)cc3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 24758299 | 164217 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 440 | 7 | 1 | 2 | 5.1 | Cc1ccccc1CCC(=O)N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C | 10.1021/jm300896d | |||
| CHEMBL2180190 | 164217 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 440 | 7 | 1 | 2 | 5.1 | Cc1ccccc1CCC(=O)N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C | 10.1021/jm300896d | |||
| 795 | 7884 | 5 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 480 | 6 | 2 | 6 | 5.1 | O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N | 10.1016/s0960-894x(01)00176-7 | |||
| 9913085 | 7884 | 5 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 480 | 6 | 2 | 6 | 5.1 | O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N | 10.1016/s0960-894x(01)00176-7 | |||
| CHEMBL20921 | 7884 | 5 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 480 | 6 | 2 | 6 | 5.1 | O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N | 10.1016/s0960-894x(01)00176-7 | |||
| 44453637 | 198288 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 468 | 4 | 1 | 4 | 4.1 | O=S(=O)(c1ccccc1Cl)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL272758 | 198288 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 468 | 4 | 1 | 4 | 4.1 | O=S(=O)(c1ccccc1Cl)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | |||
| 10505512 | 235472 | 0 | None | None | None | Mouse | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 498 | 4 | 1 | 3 | 7.1 | O=C(NC1CCN(C/C2=C/CCCCCC2)CC1)C1c2cc(Cl)ccc2Oc2ccc(Cl)cc21 | 10.1021/jm0004244 | |||
| CHEMBL33639 | 235472 | 0 | None | None | None | Mouse | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 498 | 4 | 1 | 3 | 7.1 | O=C(NC1CCN(C/C2=C/CCCCCC2)CC1)C1c2cc(Cl)ccc2Oc2ccc(Cl)cc21 | 10.1021/jm0004244 | |||
| 57889625 | 164296 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 448 | 6 | 1 | 2 | 5.8 | CCCC(NC(=O)c1ccc2ccccc2c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180545 | 164296 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 448 | 6 | 1 | 2 | 5.8 | CCCC(NC(=O)c1ccc2ccccc2c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 57888746 | 181963 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 449 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](N)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889407 | 181963 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 449 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](N)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398719 | 181963 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 449 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](N)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398721 | 181963 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 449 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](N)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 73347500 | 181994 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 475 | 5 | 2 | 3 | 4.9 | CC(C)[C@@H](NC(=O)c1ccc(Cl)cc1)C(=O)N1CC[C@](N)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398753 | 181994 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 475 | 5 | 2 | 3 | 4.9 | CC(C)[C@@H](NC(=O)c1ccc(Cl)cc1)C(=O)N1CC[C@](N)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 44453638 | 327635 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 468 | 4 | 1 | 4 | 4.1 | O=S(=O)(c1ccccc1Cl)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL427834 | 327635 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 468 | 4 | 1 | 4 | 4.1 | O=S(=O)(c1ccccc1Cl)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | |||
| 52916803 | 335526 | 28 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 451 | 5 | 1 | 7 | 2.8 | CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 | 10.1016/j.bmcl.2018.12.024 | |||
| CHEMBL4456123 | 335526 | 28 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 451 | 5 | 1 | 7 | 2.8 | CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 | 10.1016/j.bmcl.2018.12.024 | |||
| 57888907 | 233484 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 437 | 6 | 3 | 3 | 3.9 | CC[C@H](C)NC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL3334817 | 233484 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 437 | 6 | 3 | 3 | 3.9 | CC[C@H](C)NC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1021/jm5003167 | |||
| 11744314 | 178226 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 446 | 6 | 3 | 6 | 3.2 | CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| CHEMBL2332935 | 178226 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 446 | 6 | 3 | 6 | 3.2 | CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| 57840363 | 177742 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 464 | 4 | 0 | 5 | 4.3 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)[C@@H](C)C2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322853 | 177742 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 464 | 4 | 0 | 5 | 4.3 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)[C@@H](C)C2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 57889099 | 233478 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 449 | 5 | 3 | 3 | 4.1 | CC(C)[C@@H](NC(=O)NC1CCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| CHEMBL3334725 | 233478 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 449 | 5 | 3 | 3 | 4.1 | CC(C)[C@@H](NC(=O)NC1CCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| 118714001 | 233481 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 465 | 5 | 4 | 4 | 3.0 | CC(C)[C@@H](NC(=O)N[C@@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| CHEMBL3334728 | 233481 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 465 | 5 | 4 | 4 | 3.0 | CC(C)[C@@H](NC(=O)N[C@@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| 57888907 | 233484 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 437 | 6 | 3 | 3 | 3.9 | CC[C@H](C)NC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL3334817 | 233484 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 437 | 6 | 3 | 3 | 3.9 | CC[C@H](C)NC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1021/jm5003167 | |||
| 118714035 | 233488 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 439 | 6 | 4 | 4 | 2.5 | CC(C)[C@@H](NC(=O)NC[C@H](C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| CHEMBL3334821 | 233488 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 439 | 6 | 4 | 4 | 2.5 | CC(C)[C@@H](NC(=O)NC[C@H](C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| 118714036 | 233489 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 424 | 6 | 3 | 4 | 2.7 | CC(C)[C@@H](NC(=O)C[C@@H](C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| CHEMBL3334822 | 233489 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 424 | 6 | 3 | 4 | 2.7 | CC(C)[C@@H](NC(=O)C[C@@H](C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| 118714037 | 233490 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 439 | 6 | 4 | 4 | 2.5 | CC(C)[C@@H](NC(=O)NC[C@@H](C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| CHEMBL3334823 | 233490 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 439 | 6 | 4 | 4 | 2.5 | CC(C)[C@@H](NC(=O)NC[C@@H](C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| 118714038 | 233491 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 452 | 7 | 3 | 4 | 3.5 | CC(C)[C@@H](NC(=O)CCC(C)(C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| CHEMBL3334825 | 233491 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 452 | 7 | 3 | 4 | 3.5 | CC(C)[C@@H](NC(=O)CCC(C)(C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| 10698568 | 25460 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 459 | 5 | 1 | 2 | 6.3 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1016/j.ejmech.2020.113085 | |||
| CHEMBL1178613 | 25460 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 459 | 5 | 1 | 2 | 6.3 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1016/j.ejmech.2020.113085 | |||
| 10698568 | 25460 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 459 | 5 | 1 | 2 | 6.3 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1178613 | 25460 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 459 | 5 | 1 | 2 | 6.3 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| 57889003 | 181969 | 9 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889430 | 181969 | 9 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398726 | 181969 | 9 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398728 | 181969 | 9 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 25175283 | 258166 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 468 | 4 | 2 | 3 | 4.8 | CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)c2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL3679637 | 258166 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 468 | 4 | 2 | 3 | 4.8 | CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)c2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| 71681399 | 181967 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 449 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CCC[C@@H]1N)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398724 | 181967 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 449 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CCC[C@@H]1N)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889077 | 181989 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 448 | 5 | 2 | 3 | 4.5 | CC(C)[C@@H](NC(=O)C1CCCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398748 | 181989 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 448 | 5 | 2 | 3 | 4.5 | CC(C)[C@@H](NC(=O)C1CCCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 59444189 | 336714 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 510 | 6 | 2 | 7 | 3.4 | CC(C)(CC(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)NC(=O)c1cccc(-n2cnnn2)c1 | nan | |||
| CHEMBL4473668 | 336714 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 510 | 6 | 2 | 7 | 3.4 | CC(C)(CC(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)NC(=O)c1cccc(-n2cnnn2)c1 | nan | |||
| 72945511 | 214043 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 485 | 8 | 3 | 6 | 3.3 | COc1ccc(NC(=O)NC2CC2)c(OC[C@@H](O)CN2CCC3(CC2)Cc2cc(F)ccc2O3)c1 | 10.1016/j.bmcl.2013.11.062 | |||
| CHEMBL3099946 | 214043 | 0 | None | None | None | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 485 | 8 | 3 | 6 | 3.3 | COc1ccc(NC(=O)NC2CC2)c(OC[C@@H](O)CN2CCC3(CC2)Cc2cc(F)ccc2O3)c1 | 10.1016/j.bmcl.2013.11.062 | |||
| 57991707 | 181965 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CCC[C@@H]1O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398722 | 181965 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CCC[C@@H]1O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 71680936 | 181991 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 563 | 8 | 3 | 6 | 3.2 | CC(C)[C@@H](NC(=O)C1CCCC1(O)CCN1CCOCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398750 | 181991 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 563 | 8 | 3 | 6 | 3.2 | CC(C)[C@@H](NC(=O)C1CCCC1(O)CCN1CCOCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 52916803 | 335526 | 28 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 451 | 5 | 1 | 7 | 2.8 | CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 | 10.6019/CHEMBL5210121 | |||
| CHEMBL4456123 | 335526 | 28 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 451 | 5 | 1 | 7 | 2.8 | CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 | 10.6019/CHEMBL5210121 | |||
| 52916803 | 335526 | 28 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 451 | 5 | 1 | 7 | 2.8 | CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 | 10.6019/CHEMBL4507278 | |||
| CHEMBL4456123 | 335526 | 28 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 451 | 5 | 1 | 7 | 2.8 | CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 | 10.6019/CHEMBL4507278 | |||
| 21070989 | 177765 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322875 | 177765 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 68963393 | 181598 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 504 | 6 | 2 | 6 | 2.9 | O=C(c1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@H](O)C1 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391800 | 181598 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 504 | 6 | 2 | 6 | 2.9 | O=C(c1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@H](O)C1 | 10.1016/j.bmcl.2013.04.047 | |||
| 10480588 | 181631 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 486 | 8 | 2 | 6 | 3.5 | COc1ccc(C(=O)NC2CC2)c(OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)c1 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391938 | 181631 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 486 | 8 | 2 | 6 | 3.5 | COc1ccc(C(=O)NC2CC2)c(OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)c1 | 10.1016/j.bmcl.2013.04.047 | |||
| 57889423 | 181988 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 434 | 5 | 2 | 3 | 4.1 | CC(C)[C@@H](NC(=O)C1CCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398747 | 181988 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 434 | 5 | 2 | 3 | 4.1 | CC(C)[C@@H](NC(=O)C1CCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 10555108 | 25447 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 445 | 4 | 1 | 2 | 5.9 | C[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1178543 | 25447 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 445 | 4 | 1 | 2 | 5.9 | C[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| 10094212 | 178227 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 430 | 6 | 3 | 6 | 2.7 | CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| CHEMBL2332936 | 178227 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 430 | 6 | 3 | 6 | 2.7 | CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| 57889347 | 181990 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 514 | 6 | 2 | 3 | 5.5 | CC(C)[C@@H](NC(=O)CC12CC3CC(CC(C3)C1)C2)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398749 | 181990 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 514 | 6 | 2 | 3 | 5.5 | CC(C)[C@@H](NC(=O)CC12CC3CC(CC(C3)C1)C2)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889003 | 181969 | 9 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889430 | 181969 | 9 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398726 | 181969 | 9 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398728 | 181969 | 9 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 10072781 | 181630 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 456 | 7 | 2 | 5 | 3.4 | O=C(NC1CC1)c1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391937 | 181630 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 456 | 7 | 2 | 5 | 3.4 | O=C(NC1CC1)c1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.04.047 | |||
| 10531632 | 25449 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 473 | 6 | 1 | 2 | 6.7 | CCC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1178571 | 25449 | 0 | None | None | None | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 473 | 6 | 1 | 2 | 6.7 | CCC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| 57888919 | 181970 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889974 | 181970 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398727 | 181970 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398729 | 181970 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889334 | 181984 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 422 | 6 | 2 | 3 | 4.0 | CC(C)CC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398743 | 181984 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 422 | 6 | 2 | 3 | 4.0 | CC(C)CC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| 57889164 | 182001 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 476 | 5 | 3 | 4 | 4.1 | CC(C)[C@@H](NC(=O)c1ccc(F)c(O)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398763 | 182001 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 476 | 5 | 3 | 4 | 4.1 | CC(C)[C@@H](NC(=O)c1ccc(F)c(O)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 71681244 | 181966 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CCC[C@H]1O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398723 | 181966 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CCC[C@H]1O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57840282 | 177734 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 460 | 4 | 0 | 5 | 3.6 | COc1cc(N2CCN(C(=O)Cn3nc(Br)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322846 | 177734 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 460 | 4 | 0 | 5 | 3.6 | COc1cc(N2CCN(C(=O)Cn3nc(Br)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 25253284 | 40074 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 450 | 4 | 1 | 5 | 4.8 | O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1nnnn1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.07.082 | |||
| CHEMBL1224119 | 40074 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 450 | 4 | 1 | 5 | 4.8 | O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1nnnn1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.07.082 | |||
| 24758406 | 164260 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 404 | 6 | 1 | 2 | 4.8 | CC(C)[C@@H](NC(=O)CC1CCCC1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180504 | 164260 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 404 | 6 | 1 | 2 | 4.8 | CC(C)[C@@H](NC(=O)CC1CCCC1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 57889047 | 233477 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 457 | 5 | 3 | 3 | 4.6 | CC(C)[C@@H](NC(=O)Nc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| CHEMBL3334724 | 233477 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 457 | 5 | 3 | 3 | 4.6 | CC(C)[C@@H](NC(=O)Nc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| 44430746 | 177992 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 530 | 10 | 3 | 8 | 2.3 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL232638 | 177992 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 530 | 10 | 3 | 8 | 2.3 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 44309195 | 202240 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 496 | 9 | 3 | 5 | 3.6 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCC(F)(F)CC1 | 10.1016/j.bmcl.2004.02.022 | |||
| CHEMBL302533 | 202240 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 496 | 9 | 3 | 5 | 3.6 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCC(F)(F)CC1 | 10.1016/j.bmcl.2004.02.022 | |||
| 44430721 | 291268 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 502 | 8 | 2 | 7 | 3.1 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(Cl)cc3)CC2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL390707 | 291268 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 502 | 8 | 2 | 7 | 3.1 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(Cl)cc3)CC2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 44453320 | 197794 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 468 | 4 | 1 | 4 | 4.1 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL270253 | 197794 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 468 | 4 | 1 | 4 | 4.1 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 10525291 | 236903 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 404 | 4 | 1 | 3 | 5.1 | O=C(NC1CCN(CC2CCCCC2)CC1)C1c2ccccc2Oc2ccccc21 | 10.1016/j.ejmech.2020.113085 | |||
| CHEMBL34053 | 236903 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 404 | 4 | 1 | 3 | 5.1 | O=C(NC1CCN(CC2CCCCC2)CC1)C1c2ccccc2Oc2ccccc21 | 10.1016/j.ejmech.2020.113085 | |||
| 10525291 | 236903 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 404 | 4 | 1 | 3 | 5.1 | O=C(NC1CCN(CC2CCCCC2)CC1)C1c2ccccc2Oc2ccccc21 | 10.1021/jm0004244 | |||
| CHEMBL34053 | 236903 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 404 | 4 | 1 | 3 | 5.1 | O=C(NC1CCN(CC2CCCCC2)CC1)C1c2ccccc2Oc2ccccc21 | 10.1021/jm0004244 | |||
| 57991713 | 181997 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 502 | 5 | 2 | 3 | 5.4 | CC(C)[C@@H](NC(=O)c1ccc(Cl)cc1)C(=O)N1CCC(O)(c2ccc(Cl)cc2)C2(CCCC2)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398759 | 181997 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 502 | 5 | 2 | 3 | 5.4 | CC(C)[C@@H](NC(=O)c1ccc(Cl)cc1)C(=O)N1CCC(O)(c2ccc(Cl)cc2)C2(CCCC2)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 73350585 | 181962 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 441 | 5 | 2 | 4 | 3.4 | CC(C)[C@@H](NC(=O)c1cccnc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C2(CC2)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398718 | 181962 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 441 | 5 | 2 | 4 | 3.4 | CC(C)[C@@H](NC(=O)c1cccnc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C2(CC2)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 71719255 | 177774 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 507 | 5 | 1 | 6 | 3.2 | CNC(=O)c1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(OC)c1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322884 | 177774 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 507 | 5 | 1 | 6 | 3.2 | CNC(=O)c1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(OC)c1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 10531239 | 26675 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 449 | 6 | 2 | 2 | 5.0 | C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C(O)(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1185795 | 26675 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 449 | 6 | 2 | 2 | 5.0 | C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C(O)(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm0004244 | |||
| 10769447 | 25459 | 0 | None | None | None | Mouse | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 447 | 4 | 1 | 2 | 6.0 | C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1178601 | 25459 | 0 | None | None | None | Mouse | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 447 | 4 | 1 | 2 | 6.0 | C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| 118714038 | 233491 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 452 | 7 | 3 | 4 | 3.5 | CC(C)[C@@H](NC(=O)CCC(C)(C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| CHEMBL3334825 | 233491 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 452 | 7 | 3 | 4 | 3.5 | CC(C)[C@@H](NC(=O)CCC(C)(C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| 24758408 | 164218 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 440 | 7 | 1 | 2 | 5.1 | Cc1cccc(CCC(=O)N[C@@H](C(=O)N2CCC(c3ccc(Cl)cc3)CC2)C(C)C)c1 | 10.1021/jm300896d | |||
| CHEMBL2180191 | 164218 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 440 | 7 | 1 | 2 | 5.1 | Cc1cccc(CCC(=O)N[C@@H](C(=O)N2CCC(c3ccc(Cl)cc3)CC2)C(C)C)c1 | 10.1021/jm300896d | |||
| 44309163 | 202775 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 462 | 11 | 3 | 5 | 3.5 | CNC(=O)[C@H](CCC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL304845 | 202775 | 0 | None | None | None | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 462 | 11 | 3 | 5 | 3.5 | CNC(=O)[C@H](CCC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.021 | |||
| 71718647 | 177775 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 521 | 5 | 0 | 6 | 3.6 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(C(=O)N(C)C)c1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322885 | 177775 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 521 | 5 | 0 | 6 | 3.6 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(C(=O)N(C)C)c1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 44430836 | 178855 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 522 | 8 | 2 | 8 | 3.5 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(Cl)s3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL234276 | 178855 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 522 | 8 | 2 | 8 | 3.5 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(Cl)s3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 44453162 | 195643 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 526 | 4 | 1 | 4 | 4.6 | CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Br | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL256272 | 195643 | 0 | None | None | None | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 526 | 4 | 1 | 4 | 4.6 | CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Br | 10.1016/j.bmcl.2007.09.068 | |||
| 71682816 | 181998 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 428 | 6 | 2 | 3 | 4.7 | CC(C)[C@H](CN1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)NC(=O)c1ccccc1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398760 | 181998 | 0 | None | None | None | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 428 | 6 | 2 | 3 | 4.7 | CC(C)[C@H](CN1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)NC(=O)c1ccccc1 | 10.1016/j.bmcl.2013.04.079 | |||
| 44308819 | 203236 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 453 | 10 | 3 | 4 | 4.5 | CNC(=O)[C@@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.022 | |||
| 44308902 | 203236 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 453 | 10 | 3 | 4 | 4.5 | CNC(=O)[C@@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.022 | |||
| CHEMBL308243 | 203236 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 453 | 10 | 3 | 4 | 4.5 | CNC(=O)[C@@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.022 | |||
| CHEMBL68937 | 203236 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 453 | 10 | 3 | 4 | 4.5 | CNC(=O)[C@@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.022 | |||
| 24745662 | 332413 | 5 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 484 | 7 | 1 | 5 | 3.4 | C[C@H]1CN(C(=O)COc2ccc(Cl)cc2CS(=O)(=O)O)[C@H](C)CN1Cc1ccc(F)cc1 | 10.1016/j.bmcl.2007.03.037 | |||
| 9935062 | 332413 | 5 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 484 | 7 | 1 | 5 | 3.4 | C[C@H]1CN(C(=O)COc2ccc(Cl)cc2CS(=O)(=O)O)[C@H](C)CN1Cc1ccc(F)cc1 | 10.1016/j.bmcl.2007.03.037 | |||
| CHEMBL430166 | 332413 | 5 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 484 | 7 | 1 | 5 | 3.4 | C[C@H]1CN(C(=O)COc2ccc(Cl)cc2CS(=O)(=O)O)[C@H](C)CN1Cc1ccc(F)cc1 | 10.1016/j.bmcl.2007.03.037 | |||
| 57840512 | 177745 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 464 | 4 | 0 | 5 | 4.3 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)C[C@@H]2C)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322856 | 177745 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 464 | 4 | 0 | 5 | 4.3 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)C[C@@H]2C)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 25233755 | 353230 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 457 | 4 | 1 | 2 | 5.2 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1F | 10.1021/jm801416q | |||
| CHEMBL473532 | 353230 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 457 | 4 | 1 | 2 | 5.2 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1F | 10.1021/jm801416q | |||
| 44308819 | 203236 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 453 | 10 | 3 | 4 | 4.5 | CNC(=O)[C@@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.020 | |||
| 44308819 | 203236 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 453 | 10 | 3 | 4 | 4.5 | CNC(=O)[C@@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.021 | |||
| 44308902 | 203236 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 453 | 10 | 3 | 4 | 4.5 | CNC(=O)[C@@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.020 | |||
| 44308902 | 203236 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 453 | 10 | 3 | 4 | 4.5 | CNC(=O)[C@@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL308243 | 203236 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 453 | 10 | 3 | 4 | 4.5 | CNC(=O)[C@@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.020 | |||
| CHEMBL308243 | 203236 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 453 | 10 | 3 | 4 | 4.5 | CNC(=O)[C@@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL68937 | 203236 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 453 | 10 | 3 | 4 | 4.5 | CNC(=O)[C@@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.020 | |||
| CHEMBL68937 | 203236 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 453 | 10 | 3 | 4 | 4.5 | CNC(=O)[C@@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.021 | |||
| 44309124 | 468838 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 520 | 11 | 2 | 5 | 4.5 | CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)N1CCCC1 | 10.1016/j.bmcl.2004.02.022 | |||
| CHEMBL68692 | 468838 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 520 | 11 | 2 | 5 | 4.5 | CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)N1CCCC1 | 10.1016/j.bmcl.2004.02.022 | |||
| 57888663 | 181972 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 521 | 6 | 3 | 5 | 2.9 | CC(C)[C@@H](NC(=O)c1ccc(S(N)(=O)=O)cc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398731 | 181972 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 521 | 6 | 3 | 5 | 2.9 | CC(C)[C@@H](NC(=O)c1ccc(S(N)(=O)=O)cc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 44430718 | 177637 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 500 | 8 | 2 | 7 | 3.0 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccccc3F)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL232044 | 177637 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 500 | 8 | 2 | 7 | 3.0 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccccc3F)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 52916803 | 335526 | 28 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 451 | 5 | 1 | 7 | 2.8 | CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 | 10.6019/CHEMBL4507278 | |||
| CHEMBL4456123 | 335526 | 28 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 451 | 5 | 1 | 7 | 2.8 | CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 | 10.6019/CHEMBL4507278 | |||
| 24758174 | 164262 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 416 | 5 | 1 | 2 | 4.6 | CC(C)[C@@H](NC(=O)c1cccc(F)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180506 | 164262 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 416 | 5 | 1 | 2 | 4.6 | CC(C)[C@@H](NC(=O)c1cccc(F)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 44453504 | 195893 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 490 | 8 | 2 | 5 | 4.7 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1cccs1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL257452 | 195893 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 490 | 8 | 2 | 5 | 4.7 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1cccs1 | 10.1016/j.bmcl.2007.09.068 | |||
| 10505512 | 235472 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 498 | 4 | 1 | 3 | 7.1 | O=C(NC1CCN(C/C2=C/CCCCCC2)CC1)C1c2cc(Cl)ccc2Oc2ccc(Cl)cc21 | 10.1021/jm0004244 | |||
| CHEMBL33639 | 235472 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 498 | 4 | 1 | 3 | 7.1 | O=C(NC1CCN(C/C2=C/CCCCCC2)CC1)C1c2cc(Cl)ccc2Oc2ccc(Cl)cc21 | 10.1021/jm0004244 | |||
| 10652533 | 25451 | 0 | None | None | None | Mouse | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 603 | 4 | 1 | 2 | 7.5 | C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1178579 | 25451 | 0 | None | None | None | Mouse | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 603 | 4 | 1 | 2 | 7.5 | C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 | 10.1021/jm0004244 | |||
| 10995329 | 42045 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 563 | 13 | 4 | 4 | 5.5 | O=C(NCCCCO)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | |||
| CHEMBL126978 | 42045 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 563 | 13 | 4 | 4 | 5.5 | O=C(NCCCCO)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | |||
| 44308997 | 468729 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 447 | 10 | 3 | 4 | 3.7 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1ccc2ncccc2c1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL67803 | 468729 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 447 | 10 | 3 | 4 | 3.7 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1ccc2ncccc2c1 | 10.1016/j.bmcl.2004.02.021 | |||
| 44537841 | 1390 | 22 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 57889181 | 1390 | 22 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 9497 | 1390 | 22 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL2398716 | 1390 | 22 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL3334824 | 1390 | 22 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 24758176 | 164266 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 412 | 5 | 1 | 2 | 4.8 | Cc1ccc(C(=O)N[C@@H](C(=O)N2CCC(c3ccc(Cl)cc3)CC2)C(C)C)cc1 | 10.1021/jm300896d | |||
| CHEMBL2180510 | 164266 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 412 | 5 | 1 | 2 | 4.8 | Cc1ccc(C(=O)N[C@@H](C(=O)N2CCC(c3ccc(Cl)cc3)CC2)C(C)C)cc1 | 10.1021/jm300896d | |||
| 44430723 | 177717 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 544 | 8 | 2 | 7 | 3.1 | CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL232253 | 177717 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 544 | 8 | 2 | 7 | 3.1 | CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 44453200 | 196032 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 4.0 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1C(F)(F)F | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL258065 | 196032 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 4.0 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1C(F)(F)F | 10.1016/j.bmcl.2007.09.068 | |||
| 10555351 | 235084 | 0 | None | None | None | Mouse | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 586 | 4 | 1 | 3 | 7.3 | O=C(NC1CCN(C/C2=C/CCCCCC2)CC1)C1c2cc(Br)ccc2Oc2ccc(Br)cc21 | 10.1021/jm0004244 | |||
| CHEMBL33580 | 235084 | 0 | None | None | None | Mouse | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 586 | 4 | 1 | 3 | 7.3 | O=C(NC1CCN(C/C2=C/CCCCCC2)CC1)C1c2cc(Br)ccc2Oc2ccc(Br)cc21 | 10.1021/jm0004244 | |||
| 73353555 | 181993 | 0 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 490 | 6 | 1 | 3 | 5.5 | CO[C@]1(c2ccc(Cl)cc2)CCN(C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)C(C)C)CC1(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398752 | 181993 | 0 | None | None | None | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | 490 | 6 | 1 | 3 | 5.5 | CO[C@]1(c2ccc(Cl)cc2)CCN(C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)C(C)C)CC1(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| 44309414 | 213770 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 448 | 10 | 3 | 5 | 3.1 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnnc2ccccc12 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL309338 | 213770 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 448 | 10 | 3 | 5 | 3.1 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnnc2ccccc12 | 10.1016/j.bmcl.2004.02.021 | |||
| 57888812 | 164292 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 412 | 4 | 1 | 2 | 4.9 | CC(C)(C)C(NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180540 | 164292 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 412 | 4 | 1 | 2 | 4.9 | CC(C)(C)C(NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 24758045 | 164258 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 392 | 7 | 1 | 2 | 4.6 | CC(C)CCC(=O)N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C | 10.1021/jm300896d | |||
| CHEMBL2180502 | 164258 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 392 | 7 | 1 | 2 | 4.6 | CC(C)CCC(=O)N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C | 10.1021/jm300896d | |||
| 44430713 | 177592 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 500 | 8 | 2 | 7 | 3.0 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL231829 | 177592 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 500 | 8 | 2 | 7 | 3.0 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 44430756 | 178022 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 577 | 10 | 2 | 8 | 3.9 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2ccncc2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL232654 | 178022 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 577 | 10 | 2 | 8 | 3.9 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2ccncc2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 44309327 | 468908 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 446 | 9 | 3 | 5 | 3.0 | NC(=O)[C@@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCCC1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL69274 | 468908 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 446 | 9 | 3 | 5 | 3.0 | NC(=O)[C@@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCCC1 | 10.1016/j.bmcl.2004.02.021 | |||
| 17753030 | 177887 | 0 | None | None | None | Mouse | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 486 | 7 | 2 | 7 | 2.5 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(N)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL232441 | 177887 | 0 | None | None | None | Mouse | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 486 | 7 | 2 | 7 | 2.5 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(N)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 10873705 | 199544 | 9 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.8 | O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(01)00176-7 | |||
| CHEMBL282285 | 199544 | 9 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 431 | 6 | 1 | 5 | 4.8 | O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1016/s0960-894x(01)00176-7 | |||
| 44309178 | 203142 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 466 | 10 | 3 | 5 | 3.3 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccc(F)cc1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL307535 | 203142 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 466 | 10 | 3 | 5 | 3.3 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccc(F)cc1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.021 | |||
| 57390926 | 140135 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 427 | 7 | 2 | 6 | 2.6 | Cc1noc(C)c1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2011.09.013 | |||
| CHEMBL1910159 | 140135 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 427 | 7 | 2 | 6 | 2.6 | Cc1noc(C)c1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2011.09.013 | |||
| 57888925 | 164295 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 426 | 4 | 1 | 2 | 5.2 | Cc1ccccc1C(=O)NC(C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)(C)C | 10.1021/jm300896d | |||
| CHEMBL2180544 | 164295 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 426 | 4 | 1 | 2 | 5.2 | Cc1ccccc1C(=O)NC(C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)(C)C | 10.1021/jm300896d | |||
| 57889874 | 164271 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 414 | 5 | 1 | 3 | 4.9 | CC(C)C(NC(=O)Oc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180517 | 164271 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 414 | 5 | 1 | 3 | 4.9 | CC(C)C(NC(=O)Oc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 44309122 | 202876 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 482 | 11 | 4 | 6 | 3.4 | CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NO | 10.1016/j.bmcl.2004.02.022 | |||
| CHEMBL305423 | 202876 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 482 | 11 | 4 | 6 | 3.4 | CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NO | 10.1016/j.bmcl.2004.02.022 | |||
| 25231300 | 348333 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 419 | 5 | 1 | 2 | 5.0 | CCN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 | 10.1021/jm801416q | |||
| CHEMBL454942 | 348333 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 419 | 5 | 1 | 2 | 5.0 | CCN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 | 10.1021/jm801416q | |||
| 25231301 | 348417 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 405 | 4 | 1 | 2 | 4.6 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 | 10.1021/jm801416q | |||
| CHEMBL455162 | 348417 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 405 | 4 | 1 | 2 | 4.6 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 | 10.1021/jm801416q | |||
| 44430716 | 177635 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 560 | 8 | 2 | 7 | 3.6 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(Br)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL232042 | 177635 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 560 | 8 | 2 | 7 | 3.6 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(Br)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 10531632 | 25449 | 0 | None | None | None | Mouse | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 473 | 6 | 1 | 2 | 6.7 | CCC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1178571 | 25449 | 0 | None | None | None | Mouse | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 473 | 6 | 1 | 2 | 6.7 | CCC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| 10507823 | 25455 | 0 | None | None | None | Mouse | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 475 | 6 | 1 | 2 | 6.8 | CCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1178590 | 25455 | 0 | None | None | None | Mouse | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 475 | 6 | 1 | 2 | 6.8 | CCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| 21071083 | 177762 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 416 | 4 | 0 | 5 | 3.2 | COc1cccc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)c1 | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322872 | 177762 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 416 | 4 | 0 | 5 | 3.2 | COc1cccc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)c1 | 10.1016/j.bmcl.2013.01.005 | |||
| 59278314 | 334482 | 29 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 425 | 5 | 1 | 7 | 2.3 | CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1 | 10.1016/j.bmcl.2018.12.024 | |||
| CHEMBL4441094 | 334482 | 29 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 425 | 5 | 1 | 7 | 2.3 | CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1 | 10.1016/j.bmcl.2018.12.024 | |||
| 24758044 | 164277 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 57888953 | 164277 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 71455572 | 164277 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180523 | 164277 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180528 | 164277 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180534 | 164277 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 10049340 | 202703 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 448 | 11 | 3 | 5 | 3.3 | CC(C)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O | 10.1016/j.bmcl.2004.02.021 | |||
| 10049340 | 202703 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 448 | 11 | 3 | 5 | 3.3 | CC(C)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O | 10.1016/j.bmcl.2004.02.022 | |||
| CHEMBL304358 | 202703 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 448 | 11 | 3 | 5 | 3.3 | CC(C)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL304358 | 202703 | 0 | None | None | None | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 448 | 11 | 3 | 5 | 3.3 | CC(C)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O | 10.1016/j.bmcl.2004.02.022 | |||
| 44309105 | 468819 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 468 | 10 | 3 | 5 | 3.1 | NC(=O)[C@H](Cc1ccccc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL68551 | 468819 | 0 | None | None | None | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 468 | 10 | 3 | 5 | 3.1 | NC(=O)[C@H](Cc1ccccc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.021 | |||
| 71460999 | 164297 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 416 | 5 | 3 | 4 | 2.3 | CC(O)C(NC(=O)c1ccccc1)C(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180546 | 164297 | 0 | None | None | None | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | 416 | 5 | 3 | 4 | 2.3 | CC(O)C(NC(=O)c1ccccc1)C(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 73355055 | 181995 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 427 | 5 | 1 | 3 | 4.5 | CC(C)[C@@H](NC(=O)c1cccnc1)C(=O)N1CC[C@H](c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398757 | 181995 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 427 | 5 | 1 | 3 | 4.5 | CC(C)[C@@H](NC(=O)c1cccnc1)C(=O)N1CC[C@H](c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 25233582 | 373199 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 401 | 5 | 1 | 3 | 4.0 | COc1ccc(NC(=O)N2CCC[C@@H]2C(=O)N(C)Cc2ccc(Cl)cc2)cc1 | 10.1021/jm801416q | |||
| CHEMBL517290 | 373199 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 401 | 5 | 1 | 3 | 4.0 | COc1ccc(NC(=O)N2CCC[C@@H]2C(=O)N(C)Cc2ccc(Cl)cc2)cc1 | 10.1021/jm801416q | |||
| 44309213 | 468719 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 478 | 11 | 3 | 6 | 3.1 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccc(OC)cc1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL67757 | 468719 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 478 | 11 | 3 | 6 | 3.1 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccc(OC)cc1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.021 | |||
| 44430720 | 177714 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 500 | 8 | 2 | 7 | 3.0 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3cccc(F)c3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL232251 | 177714 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 500 | 8 | 2 | 7 | 3.0 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3cccc(F)c3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 57888758 | 181973 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 486 | 6 | 3 | 4 | 3.9 | CC(C)[C@@H](NC(=O)c1ccccc1C(=O)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398732 | 181973 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 486 | 6 | 3 | 4 | 3.9 | CC(C)[C@@H](NC(=O)c1ccccc1C(=O)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 11828215 | 233470 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 613 | 12 | 3 | 3 | 7.1 | O=C(NCCc1ccc(F)cc1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | |||
| CHEMBL333422 | 233470 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 613 | 12 | 3 | 3 | 7.1 | O=C(NCCc1ccc(F)cc1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | |||
| 25233753 | 350934 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 439 | 4 | 1 | 2 | 5.0 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1cccc(C(F)(F)F)c1 | 10.1021/jm801416q | |||
| CHEMBL462442 | 350934 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 439 | 4 | 1 | 2 | 5.0 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1cccc(C(F)(F)F)c1 | 10.1021/jm801416q | |||
| 57889099 | 233478 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 449 | 5 | 3 | 3 | 4.1 | CC(C)[C@@H](NC(=O)NC1CCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| CHEMBL3334725 | 233478 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 449 | 5 | 3 | 3 | 4.1 | CC(C)[C@@H](NC(=O)NC1CCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| 57889314 | 181986 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 406 | 5 | 2 | 3 | 3.3 | CC(C)[C@@H](NC(=O)C1CC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398745 | 181986 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 406 | 5 | 2 | 3 | 3.3 | CC(C)[C@@H](NC(=O)C1CC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57888900 | 182005 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 521 | 6 | 3 | 5 | 2.9 | CC(C)[C@@H](NC(=O)c1cccc(S(N)(=O)=O)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398767 | 182005 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 521 | 6 | 3 | 5 | 2.9 | CC(C)[C@@H](NC(=O)c1cccc(S(N)(=O)=O)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 44537841 | 1390 | 22 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 57889181 | 1390 | 22 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 9497 | 1390 | 22 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL2398716 | 1390 | 22 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL3334824 | 1390 | 22 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 57889736 | 233480 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 465 | 5 | 4 | 4 | 3.0 | CC(C)[C@@H](NC(=O)N[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| CHEMBL3334727 | 233480 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 465 | 5 | 4 | 4 | 3.0 | CC(C)[C@@H](NC(=O)N[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| 57888785 | 233482 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 465 | 5 | 4 | 4 | 3.0 | CC(C)[C@@H](NC(=O)N[C@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| CHEMBL3334815 | 233482 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 465 | 5 | 4 | 4 | 3.0 | CC(C)[C@@H](NC(=O)N[C@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| 57889188 | 233483 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 437 | 6 | 3 | 3 | 3.9 | CC[C@@H](C)NC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL3334816 | 233483 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 437 | 6 | 3 | 3 | 3.9 | CC[C@@H](C)NC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1021/jm5003167 | |||
| 57991707 | 181965 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CCC[C@@H]1O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398722 | 181965 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CCC[C@@H]1O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 10509339 | 26639 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 631 | 6 | 1 | 2 | 8.3 | CCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1185511 | 26639 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 631 | 6 | 1 | 2 | 8.3 | CCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 | 10.1021/jm0004244 | |||
| 10094211 | 181592 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 430 | 6 | 3 | 6 | 2.1 | CNC(=O)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391794 | 181592 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 430 | 6 | 3 | 6 | 2.1 | CNC(=O)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | 10.1016/j.bmcl.2013.04.047 | |||
| 44537841 | 1390 | 22 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 57889181 | 1390 | 22 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 9497 | 1390 | 22 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL2398716 | 1390 | 22 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL3334824 | 1390 | 22 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 10393066 | 214045 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 447 | 6 | 4 | 6 | 2.7 | NC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.11.062 | |||
| CHEMBL3099948 | 214045 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 447 | 6 | 4 | 6 | 2.7 | NC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.11.062 | |||
| 72945112 | 214058 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 445 | 6 | 4 | 6 | 2.5 | CNC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | 10.1016/j.bmcl.2013.11.062 | |||
| CHEMBL3099961 | 214058 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 445 | 6 | 4 | 6 | 2.5 | CNC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | 10.1016/j.bmcl.2013.11.062 | |||
| 44537841 | 1390 | 22 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 57889181 | 1390 | 22 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 9497 | 1390 | 22 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL2398716 | 1390 | 22 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL3334824 | 1390 | 22 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 57888895 | 181971 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 476 | 5 | 2 | 3 | 4.9 | CC(C)[C@@H](NC(=O)c1ccc(Cl)cc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398730 | 181971 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 476 | 5 | 2 | 3 | 4.9 | CC(C)[C@@H](NC(=O)c1ccc(Cl)cc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 10676520 | 25452 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 617 | 5 | 1 | 2 | 7.9 | CC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1178581 | 25452 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 617 | 5 | 1 | 2 | 7.9 | CC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 | 10.1021/jm0004244 | |||
| 57889023 | 182003 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 576 | 7 | 4 | 4 | 5.4 | CC(C)[C@@H](NC(=O)c1cccc(-c2ccccc2NC(N)=O)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398765 | 182003 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 576 | 7 | 4 | 4 | 5.4 | CC(C)[C@@H](NC(=O)c1cccc(-c2ccccc2NC(N)=O)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889764 | 182007 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 457 | 6 | 2 | 4 | 3.6 | CC(C)[C@@H](NC(=O)Cc1ccncc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398769 | 182007 | 0 | None | None | None | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 457 | 6 | 2 | 4 | 3.6 | CC(C)[C@@H](NC(=O)Cc1ccncc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889843 | 181982 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 394 | 5 | 2 | 3 | 3.3 | CCC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398741 | 181982 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 394 | 5 | 2 | 3 | 3.3 | CCC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| 10507823 | 25455 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 475 | 6 | 1 | 2 | 6.8 | CCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1178590 | 25455 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 475 | 6 | 1 | 2 | 6.8 | CCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| 73355055 | 181995 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 427 | 5 | 1 | 3 | 4.5 | CC(C)[C@@H](NC(=O)c1cccnc1)C(=O)N1CC[C@H](c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398757 | 181995 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 427 | 5 | 1 | 3 | 4.5 | CC(C)[C@@H](NC(=O)c1cccnc1)C(=O)N1CC[C@H](c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 21070989 | 177765 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322875 | 177765 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 10652533 | 25451 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 603 | 4 | 1 | 2 | 7.5 | C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1178579 | 25451 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 603 | 4 | 1 | 2 | 7.5 | C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1 | 10.1021/jm0004244 | |||
| 44431524 | 292015 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 476 | 8 | 2 | 5 | 2.7 | C[C@H]1CN(C(=O)COc2ccc(Cl)cc2C(=O)NCCN)[C@H](C)CN1Cc1ccc(F)cc1 | 10.1016/j.bmcl.2007.03.037 | |||
| CHEMBL391302 | 292015 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 476 | 8 | 2 | 5 | 2.7 | C[C@H]1CN(C(=O)COc2ccc(Cl)cc2C(=O)NCCN)[C@H](C)CN1Cc1ccc(F)cc1 | 10.1016/j.bmcl.2007.03.037 | |||
| 24758044 | 164277 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57888953 | 164277 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| 71455572 | 164277 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2180523 | 164277 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2180528 | 164277 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2180534 | 164277 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| 24758294 | 164252 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 412 | 6 | 1 | 2 | 4.4 | CC(C)[C@@H](NC(=O)Cc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 24758856 | 164252 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 412 | 6 | 1 | 2 | 4.4 | CC(C)[C@@H](NC(=O)Cc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180496 | 164252 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 412 | 6 | 1 | 2 | 4.4 | CC(C)[C@@H](NC(=O)Cc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180514 | 164252 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 412 | 6 | 1 | 2 | 4.4 | CC(C)[C@@H](NC(=O)Cc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 44453359 | 197863 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 408 | 7 | 2 | 4 | 3.0 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL270631 | 197863 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 408 | 7 | 2 | 4 | 3.0 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1016/j.bmcl.2007.09.068 | |||
| 21070989 | 177765 | 0 | None | None | None | Mouse | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322875 | 177765 | 0 | None | None | None | Mouse | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 44308819 | 203236 | 0 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 453 | 10 | 3 | 4 | 4.5 | CNC(=O)[C@@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.020 | |||
| 44308902 | 203236 | 0 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 453 | 10 | 3 | 4 | 4.5 | CNC(=O)[C@@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.020 | |||
| CHEMBL308243 | 203236 | 0 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 453 | 10 | 3 | 4 | 4.5 | CNC(=O)[C@@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.020 | |||
| CHEMBL68937 | 203236 | 0 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 453 | 10 | 3 | 4 | 4.5 | CNC(=O)[C@@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.020 | |||
| 57888688 | 164273 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 448 | 7 | 1 | 3 | 4.2 | CC(C)C(NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180519 | 164273 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 448 | 7 | 1 | 3 | 4.2 | CC(C)C(NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 1370410 | 177778 | 10 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 404 | 3 | 0 | 4 | 3.4 | Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322888 | 177778 | 10 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 404 | 3 | 0 | 4 | 3.4 | Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2013.01.005 | |||
| 512282 | 1562 | 44 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2007.03.037 | |||
| 767 | 1562 | 44 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2007.03.037 | |||
| CHEMBL232656 | 1562 | 44 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2007.03.037 | |||
| 10995218 | 40500 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 549 | 12 | 4 | 4 | 5.1 | O=C(NCCCO)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | |||
| CHEMBL124127 | 40500 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 549 | 12 | 4 | 4 | 5.1 | O=C(NCCCO)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | |||
| 10974378 | 233316 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 664 | 12 | 3 | 4 | 7.4 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)NC1CCN(Cc2ccccc2)CC1 | 10.1021/jm0201767 | |||
| CHEMBL333063 | 233316 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 664 | 12 | 3 | 4 | 7.4 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)NC1CCN(Cc2ccccc2)CC1 | 10.1021/jm0201767 | |||
| 10255511 | 181609 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 502 | 6 | 2 | 7 | 2.7 | O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCOCC1 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391811 | 181609 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 502 | 6 | 2 | 7 | 2.7 | O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCOCC1 | 10.1016/j.bmcl.2013.04.047 | |||
| 25254218 | 40075 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 449 | 4 | 1 | 4 | 5.4 | O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1ncnn1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.07.082 | |||
| CHEMBL1224120 | 40075 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 449 | 4 | 1 | 4 | 5.4 | O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1ncnn1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.07.082 | |||
| 24758172 | 164265 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 412 | 5 | 1 | 2 | 4.8 | Cc1ccccc1C(=O)N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C | 10.1021/jm300896d | |||
| 24759191 | 164265 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 412 | 5 | 1 | 2 | 4.8 | Cc1ccccc1C(=O)N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C | 10.1021/jm300896d | |||
| CHEMBL2180509 | 164265 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 412 | 5 | 1 | 2 | 4.8 | Cc1ccccc1C(=O)N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C | 10.1021/jm300896d | |||
| CHEMBL2180542 | 164265 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 412 | 5 | 1 | 2 | 4.8 | Cc1ccccc1C(=O)N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C | 10.1021/jm300896d | |||
| 24758173 | 164279 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 378 | 6 | 1 | 2 | 4.2 | CC(C)CC(=O)N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C | 10.1021/jm300896d | |||
| CHEMBL2180525 | 164279 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 378 | 6 | 1 | 2 | 4.2 | CC(C)CC(=O)N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C | 10.1021/jm300896d | |||
| 11464915 | 214049 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 442 | 5 | 2 | 5 | 3.4 | O=C1CCc2cccc(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)c2N1 | 10.1016/j.bmcl.2013.11.062 | |||
| CHEMBL3099952 | 214049 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 442 | 5 | 2 | 5 | 3.4 | O=C1CCc2cccc(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)c2N1 | 10.1016/j.bmcl.2013.11.062 | |||
| 68817337 | 178230 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 425 | 7 | 2 | 6 | 2.8 | COc1ccc(NC(C)=O)c(OC[C@@H](N)CN2CCC3(CC2)Cc2ccccc2O3)c1 | 10.1016/j.bmcl.2012.12.095 | |||
| CHEMBL2332939 | 178230 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 425 | 7 | 2 | 6 | 2.8 | COc1ccc(NC(C)=O)c(OC[C@@H](N)CN2CCC3(CC2)Cc2ccccc2O3)c1 | 10.1016/j.bmcl.2012.12.095 | |||
| 44453161 | 195642 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 482 | 4 | 1 | 4 | 4.5 | CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Cl | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL256271 | 195642 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 482 | 4 | 1 | 4 | 4.5 | CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Cl | 10.1016/j.bmcl.2007.09.068 | |||
| 21071096 | 177783 | 0 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 416 | 4 | 0 | 5 | 3.2 | COc1ccc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc1 | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322893 | 177783 | 0 | None | None | None | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 416 | 4 | 0 | 5 | 3.2 | COc1ccc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc1 | 10.1016/j.bmcl.2013.01.005 | |||
| 57889972 | 164301 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 428 | 6 | 2 | 3 | 4.0 | CC(C)CC(NC(=O)c1ccccc1)C(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180550 | 164301 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 428 | 6 | 2 | 3 | 4.0 | CC(C)CC(NC(=O)c1ccccc1)C(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 21071106 | 177828 | 1 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 400 | 3 | 0 | 4 | 3.5 | Cc1cccc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)c1 | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2323422 | 177828 | 1 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 400 | 3 | 0 | 4 | 3.5 | Cc1cccc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)c1 | 10.1016/j.bmcl.2013.01.005 | |||
| 71457362 | 164280 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 392 | 7 | 1 | 2 | 4.6 | CC[C@@H](C)[C@@H](NC(=O)CC(C)C)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180526 | 164280 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 392 | 7 | 1 | 2 | 4.6 | CC[C@@H](C)[C@@H](NC(=O)CC(C)C)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 21071046 | 177736 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 397 | 4 | 1 | 6 | 2.4 | COc1cc(N2CCN(C(=O)Cn3nc(N)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322848 | 177736 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 397 | 4 | 1 | 6 | 2.4 | COc1cc(N2CCN(C(=O)Cn3nc(N)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 21070990 | 177756 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 512 | 5 | 0 | 5 | 5.2 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3-c3ccccc3)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322866 | 177756 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 512 | 5 | 0 | 5 | 5.2 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3-c3ccccc3)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 57888746 | 181963 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 449 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](N)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889407 | 181963 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 449 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](N)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398719 | 181963 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 449 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](N)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398721 | 181963 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 449 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](N)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 44309161 | 468792 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 462 | 9 | 3 | 6 | 2.3 | NC(=O)[C@@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1 | 10.1016/j.bmcl.2004.02.022 | |||
| 44309166 | 468792 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 462 | 9 | 3 | 6 | 2.3 | NC(=O)[C@@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1 | 10.1016/j.bmcl.2004.02.022 | |||
| CHEMBL68368 | 468792 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 462 | 9 | 3 | 6 | 2.3 | NC(=O)[C@@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1 | 10.1016/j.bmcl.2004.02.022 | |||
| CHEMBL69876 | 468792 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 462 | 9 | 3 | 6 | 2.3 | NC(=O)[C@@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1 | 10.1016/j.bmcl.2004.02.022 | |||
| 24758171 | 164255 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 426 | 7 | 1 | 2 | 4.8 | CC(C)[C@@H](NC(=O)CCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 24759081 | 164255 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 426 | 7 | 1 | 2 | 4.8 | CC(C)[C@@H](NC(=O)CCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180499 | 164255 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 426 | 7 | 1 | 2 | 4.8 | CC(C)[C@@H](NC(=O)CCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180515 | 164255 | 0 | None | None | None | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 426 | 7 | 1 | 2 | 4.8 | CC(C)[C@@H](NC(=O)CCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 44430714 | 177593 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 482 | 8 | 2 | 7 | 2.8 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccccc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL231830 | 177593 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 482 | 8 | 2 | 7 | 2.8 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccccc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 44453503 | 195455 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 490 | 8 | 2 | 5 | 4.7 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1ccsc1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL255338 | 195455 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 490 | 8 | 2 | 5 | 4.7 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1ccsc1 | 10.1016/j.bmcl.2007.09.068 | |||
| 44453164 | 196096 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 492 | 8 | 2 | 5 | 3.9 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1OC(F)(F)F | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL258361 | 196096 | 0 | None | None | None | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 492 | 8 | 2 | 5 | 3.9 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1OC(F)(F)F | 10.1016/j.bmcl.2007.09.068 | |||
| 10555108 | 25447 | 0 | None | None | None | Mouse | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 445 | 4 | 1 | 2 | 5.9 | C[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1178543 | 25447 | 0 | None | None | None | Mouse | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 445 | 4 | 1 | 2 | 5.9 | C[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| 44309161 | 468792 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 462 | 9 | 3 | 6 | 2.3 | NC(=O)[C@@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1 | 10.1016/j.bmcl.2004.02.021 | |||
| 44309166 | 468792 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 462 | 9 | 3 | 6 | 2.3 | NC(=O)[C@@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL68368 | 468792 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 462 | 9 | 3 | 6 | 2.3 | NC(=O)[C@@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL69876 | 468792 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 462 | 9 | 3 | 6 | 2.3 | NC(=O)[C@@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1 | 10.1016/j.bmcl.2004.02.021 | |||
| 44453195 | 311166 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 496 | 4 | 1 | 4 | 4.8 | Cc1cccc(Cl)c1S(=O)(=O)N1CCC(C)(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL402327 | 311166 | 0 | None | None | None | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | 496 | 4 | 1 | 4 | 4.8 | Cc1cccc(Cl)c1S(=O)(=O)N1CCC(C)(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 24758172 | 164265 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 412 | 5 | 1 | 2 | 4.8 | Cc1ccccc1C(=O)N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C | 10.1021/jm300896d | |||
| 24759191 | 164265 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 412 | 5 | 1 | 2 | 4.8 | Cc1ccccc1C(=O)N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C | 10.1021/jm300896d | |||
| CHEMBL2180509 | 164265 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 412 | 5 | 1 | 2 | 4.8 | Cc1ccccc1C(=O)N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C | 10.1021/jm300896d | |||
| CHEMBL2180542 | 164265 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 412 | 5 | 1 | 2 | 4.8 | Cc1ccccc1C(=O)N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C | 10.1021/jm300896d | |||
| 44453400 | 195899 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 460 | 7 | 2 | 4 | 3.8 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1Cl | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL257509 | 195899 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 460 | 7 | 2 | 4 | 3.8 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1Cl | 10.1016/j.bmcl.2007.09.068 | |||
| 11104005 | 236207 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 602 | 12 | 3 | 4 | 6.2 | O=C(NCCN1CCCCC1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | |||
| CHEMBL339752 | 236207 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 602 | 12 | 3 | 4 | 6.2 | O=C(NCCN1CCCCC1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | |||
| 11113940 | 161061 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 509 | 8 | 1 | 6 | 5.9 | CCOc1ccc2nc(SCC(=O)NC3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)sc2c1 | 10.1016/s0960-894x(01)00176-7 | |||
| CHEMBL21143 | 161061 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 509 | 8 | 1 | 6 | 5.9 | CCOc1ccc2nc(SCC(=O)NC3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)sc2c1 | 10.1016/s0960-894x(01)00176-7 | |||
| 25231299 | 372207 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 433 | 6 | 1 | 2 | 5.4 | CCCN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 | 10.1021/jm801416q | |||
| CHEMBL509457 | 372207 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 433 | 6 | 1 | 2 | 5.4 | CCCN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 | 10.1021/jm801416q | |||
| 44453226 | 196101 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 536 | 4 | 1 | 4 | 5.4 | O=S(=O)(c1ccc(Cl)c(Cl)c1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL258369 | 196101 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 536 | 4 | 1 | 4 | 5.4 | O=S(=O)(c1ccc(Cl)c(Cl)c1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 21071108 | 177782 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 400 | 3 | 0 | 4 | 3.5 | Cc1ccc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc1 | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322892 | 177782 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 400 | 3 | 0 | 4 | 3.5 | Cc1ccc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc1 | 10.1016/j.bmcl.2013.01.005 | |||
| 57840518 | 177741 | 1 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 464 | 4 | 0 | 5 | 4.3 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)[C@H](C)C2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322852 | 177741 | 1 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 464 | 4 | 0 | 5 | 4.3 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)[C@H](C)C2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 69439557 | 214050 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 440 | 5 | 2 | 5 | 3.4 | O=c1ccc2cccc(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)c2[nH]1 | 10.1016/j.bmcl.2013.11.062 | |||
| CHEMBL3099953 | 214050 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 440 | 5 | 2 | 5 | 3.4 | O=c1ccc2cccc(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)c2[nH]1 | 10.1016/j.bmcl.2013.11.062 | |||
| 57888963 | 164298 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 398 | 4 | 2 | 3 | 3.5 | C/C=C(/NC(=O)c1ccccc1)C(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180547 | 164298 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 398 | 4 | 2 | 3 | 3.5 | C/C=C(/NC(=O)c1ccccc1)C(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 44453290 | 197728 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 482 | 4 | 1 | 4 | 4.4 | Cc1cccc(Cl)c1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL269956 | 197728 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 482 | 4 | 1 | 4 | 4.4 | Cc1cccc(Cl)c1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 10628025 | 25453 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 523 | 6 | 1 | 2 | 7.6 | O=C(NC1CC[N+](Cc2ccccc2)(CC2CCCCCCC2)CC1)C1c2ccccc2Oc2ccccc21 | 10.1021/jm0004244 | |||
| CHEMBL1178588 | 25453 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 523 | 6 | 1 | 2 | 7.6 | O=C(NC1CC[N+](Cc2ccccc2)(CC2CCCCCCC2)CC1)C1c2ccccc2Oc2ccccc21 | 10.1021/jm0004244 | |||
| 24740170 | 164288 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 433 | 5 | 1 | 3 | 4.1 | CC(C)C(NC(=O)c1ccccc1)C(=O)N1CCN(c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180536 | 164288 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 433 | 5 | 1 | 3 | 4.1 | CC(C)C(NC(=O)c1ccccc1)C(=O)N1CCN(c2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm300896d | |||
| 44431527 | 178850 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 448 | 7 | 1 | 4 | 3.6 | C[C@H]1CN(C(=O)COc2ccc(Cl)cc2CC(=O)O)[C@H](C)CN1Cc1ccc(F)cc1 | 10.1016/j.bmcl.2007.03.037 | |||
| CHEMBL234262 | 178850 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 448 | 7 | 1 | 4 | 3.6 | C[C@H]1CN(C(=O)COc2ccc(Cl)cc2CC(=O)O)[C@H](C)CN1Cc1ccc(F)cc1 | 10.1016/j.bmcl.2007.03.037 | |||
| 71457361 | 164253 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 426 | 7 | 1 | 2 | 4.8 | CC[C@@H](C)[C@@H](NC(=O)Cc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180497 | 164253 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 426 | 7 | 1 | 2 | 4.8 | CC[C@@H](C)[C@@H](NC(=O)Cc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 44453265 | 195757 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 442 | 7 | 2 | 4 | 3.6 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL256821 | 195757 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 442 | 7 | 2 | 4 | 3.6 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1 | 10.1016/j.bmcl.2007.09.068 | |||
| 10579693 | 25448 | 0 | None | None | None | Mouse | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 489 | 7 | 1 | 2 | 7.2 | CCCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1178558 | 25448 | 0 | None | None | None | Mouse | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 489 | 7 | 1 | 2 | 7.2 | CCCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| 57396208 | 140136 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 463 | 9 | 2 | 3 | 4.3 | O=C(NCCCCN1CCC(Oc2ccc(F)cc2)C1)NCc1ccc(Br)cc1 | 10.1016/j.bmcl.2011.09.013 | |||
| CHEMBL1910160 | 140136 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 463 | 9 | 2 | 3 | 4.3 | O=C(NCCCCN1CCC(Oc2ccc(F)cc2)C1)NCc1ccc(Br)cc1 | 10.1016/j.bmcl.2011.09.013 | |||
| 24759740 | 164289 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 364 | 5 | 1 | 2 | 3.8 | CC(C)C(=O)NC(C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C | 10.1021/jm300896d | |||
| CHEMBL2180537 | 164289 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 364 | 5 | 1 | 2 | 3.8 | CC(C)C(=O)NC(C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C | 10.1021/jm300896d | |||
| 44453641 | 198235 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 438 | 8 | 2 | 5 | 3.0 | COc1ccc(S(=O)(=O)NCCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL272559 | 198235 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 438 | 8 | 2 | 5 | 3.0 | COc1ccc(S(=O)(=O)NCCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmcl.2007.09.068 | |||
| 3497 | 2447 | 26 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1016/j.bmcl.2018.11.015 | |||
| 44309353 | 2447 | 26 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1016/j.bmcl.2018.11.015 | |||
| 5311123 | 2447 | 26 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1016/j.bmcl.2018.11.015 | |||
| CHEMBL1628706 | 2447 | 26 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1016/j.bmcl.2018.11.015 | |||
| CHEMBL308473 | 2447 | 26 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1016/j.bmcl.2018.11.015 | |||
| 44453157 | 311251 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 482 | 4 | 1 | 4 | 4.4 | Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL402827 | 311251 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 482 | 4 | 1 | 4 | 4.4 | Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | |||
| 10164 | 1805 | 30 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 451 | 4 | 1 | 8 | 2.2 | COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1[nH]c(=C2N=CC=N2)c2c1nccc2 | 10.1016/j.bmcl.2018.11.015 | |||
| 135565361 | 1805 | 30 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 451 | 4 | 1 | 8 | 2.2 | COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1[nH]c(=C2N=CC=N2)c2c1nccc2 | 10.1016/j.bmcl.2018.11.015 | |||
| 25016615 | 1805 | 30 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 451 | 4 | 1 | 8 | 2.2 | COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1[nH]c(=C2N=CC=N2)c2c1nccc2 | 10.1016/j.bmcl.2018.11.015 | |||
| CHEMBL4444976 | 1805 | 30 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 451 | 4 | 1 | 8 | 2.2 | COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1[nH]c(=C2N=CC=N2)c2c1nccc2 | 10.1016/j.bmcl.2018.11.015 | |||
| DB12963 | 1805 | 30 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 451 | 4 | 1 | 8 | 2.2 | COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1[nH]c(=C2N=CC=N2)c2c1nccc2 | 10.1016/j.bmcl.2018.11.015 | |||
| 118714001 | 233481 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 465 | 5 | 4 | 4 | 3.0 | CC(C)[C@@H](NC(=O)N[C@@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| CHEMBL3334728 | 233481 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 465 | 5 | 4 | 4 | 3.0 | CC(C)[C@@H](NC(=O)N[C@@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| 57889003 | 181969 | 9 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889430 | 181969 | 9 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398726 | 181969 | 9 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398728 | 181969 | 9 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 21070989 | 177765 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322875 | 177765 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 57889180 | 233479 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 465 | 5 | 4 | 4 | 3.0 | CC(C)[C@@H](NC(=O)N[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| CHEMBL3334726 | 233479 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 465 | 5 | 4 | 4 | 3.0 | CC(C)[C@@H](NC(=O)N[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| 57889897 | 181978 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 456 | 6 | 2 | 3 | 4.2 | CC(C)[C@@H](NC(=O)Cc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398737 | 181978 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 456 | 6 | 2 | 3 | 4.2 | CC(C)[C@@H](NC(=O)Cc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 24738063 | 181996 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 419 | 5 | 1 | 3 | 4.1 | CC(C)[C@@H](NC(=O)C1CCCC1)C(=O)N1CCN(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398758 | 181996 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 419 | 5 | 1 | 3 | 4.1 | CC(C)[C@@H](NC(=O)C1CCCC1)C(=O)N1CCN(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 44537841 | 1390 | 22 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 57889181 | 1390 | 22 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 9497 | 1390 | 22 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL2398716 | 1390 | 22 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL3334824 | 1390 | 22 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 57889979 | 181976 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 443 | 5 | 2 | 4 | 3.6 | CC(C)[C@@H](NC(=O)c1cccnc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398735 | 181976 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 443 | 5 | 2 | 4 | 3.6 | CC(C)[C@@H](NC(=O)c1cccnc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889121 | 181983 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 408 | 5 | 2 | 3 | 3.6 | CC(C)C(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398742 | 181983 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 408 | 5 | 2 | 3 | 3.6 | CC(C)C(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| 57889003 | 181969 | 9 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889430 | 181969 | 9 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398726 | 181969 | 9 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398728 | 181969 | 9 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889843 | 181982 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 394 | 5 | 2 | 3 | 3.3 | CCC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398741 | 181982 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 394 | 5 | 2 | 3 | 3.3 | CCC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| 72945310 | 214038 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 475 | 7 | 3 | 6 | 3.3 | CNC(=O)Nc1ccc(OC)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.11.062 | |||
| CHEMBL3099941 | 214038 | 0 | None | None | None | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 475 | 7 | 3 | 6 | 3.3 | CNC(=O)Nc1ccc(OC)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.11.062 | |||
| 57889121 | 181983 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 408 | 5 | 2 | 3 | 3.6 | CC(C)C(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398742 | 181983 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 408 | 5 | 2 | 3 | 3.6 | CC(C)C(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| 57888747 | 182008 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 476 | 5 | 2 | 3 | 4.9 | CC(C)[C@@H](NC(=O)c1ccccc1Cl)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398770 | 182008 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 476 | 5 | 2 | 3 | 4.9 | CC(C)[C@@H](NC(=O)c1ccccc1Cl)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57888938 | 182004 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 477 | 6 | 2 | 4 | 3.1 | CC(C)[C@@H](NC(=O)c1cccc(S(N)(=O)=O)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398766 | 182004 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 477 | 6 | 2 | 4 | 3.1 | CC(C)[C@@H](NC(=O)c1cccc(S(N)(=O)=O)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57840427 | 177731 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 396 | 4 | 0 | 5 | 3.2 | COc1cc(N2CCN(C(=O)Cn3nc(C)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322843 | 177731 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 396 | 4 | 0 | 5 | 3.2 | COc1cc(N2CCN(C(=O)Cn3nc(C)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 24758294 | 164252 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 412 | 6 | 1 | 2 | 4.4 | CC(C)[C@@H](NC(=O)Cc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 24758856 | 164252 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 412 | 6 | 1 | 2 | 4.4 | CC(C)[C@@H](NC(=O)Cc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180496 | 164252 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 412 | 6 | 1 | 2 | 4.4 | CC(C)[C@@H](NC(=O)Cc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180514 | 164252 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 412 | 6 | 1 | 2 | 4.4 | CC(C)[C@@H](NC(=O)Cc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 24758171 | 164255 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 426 | 7 | 1 | 2 | 4.8 | CC(C)[C@@H](NC(=O)CCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 24759081 | 164255 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 426 | 7 | 1 | 2 | 4.8 | CC(C)[C@@H](NC(=O)CCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180499 | 164255 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 426 | 7 | 1 | 2 | 4.8 | CC(C)[C@@H](NC(=O)CCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180515 | 164255 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 426 | 7 | 1 | 2 | 4.8 | CC(C)[C@@H](NC(=O)CCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 10435088 | 181629 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 475 | 8 | 4 | 7 | 1.9 | NCCNC(=O)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391936 | 181629 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 475 | 8 | 4 | 7 | 1.9 | NCCNC(=O)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.04.047 | |||
| 44453579 | 311536 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 482 | 4 | 1 | 4 | 4.5 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL404465 | 311536 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 482 | 4 | 1 | 4 | 4.5 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 25233577 | 350734 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 419 | 4 | 1 | 2 | 5.0 | Cc1cc(CN(C)C(=O)[C@H]2CCCN2C(=O)Nc2ccc(Cl)cc2)ccc1Cl | 10.1021/jm801416q | |||
| CHEMBL460535 | 350734 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 419 | 4 | 1 | 2 | 5.0 | Cc1cc(CN(C)C(=O)[C@H]2CCCN2C(=O)Nc2ccc(Cl)cc2)ccc1Cl | 10.1021/jm801416q | |||
| 59444242 | 334693 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 414 | 5 | 2 | 3 | 3.6 | CC1(C)CN(C(=O)CCNC(=O)c2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL4444092 | 334693 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 414 | 5 | 2 | 3 | 3.6 | CC1(C)CN(C(=O)CCNC(=O)c2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| 44453437 | 316435 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL411477 | 316435 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1Cl | 10.1016/j.bmcl.2007.09.068 | |||
| 44537841 | 1390 | 22 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 57889181 | 1390 | 22 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 9497 | 1390 | 22 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL2398716 | 1390 | 22 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL3334824 | 1390 | 22 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 59444197 | 334654 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 420 | 5 | 2 | 3 | 3.7 | CC(CNC(=O)C1CCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | nan | |||
| CHEMBL4443458 | 334654 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 420 | 5 | 2 | 3 | 3.7 | CC(CNC(=O)C1CCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | nan | |||
| 44430755 | 309540 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 577 | 10 | 2 | 8 | 3.9 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL397910 | 309540 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 577 | 10 | 2 | 8 | 3.9 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 71717437 | 177772 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 494 | 5 | 1 | 6 | 3.6 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(C(=O)O)c1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322882 | 177772 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 494 | 5 | 1 | 6 | 3.6 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(C(=O)O)c1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 44453321 | 197795 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 502 | 4 | 1 | 4 | 4.8 | O=S(=O)(c1c(Cl)cccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL270254 | 197795 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 502 | 4 | 1 | 4 | 4.8 | O=S(=O)(c1c(Cl)cccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 44309171 | 468989 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 462 | 12 | 3 | 5 | 3.7 | CC(C)CCC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL69816 | 468989 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 462 | 12 | 3 | 5 | 3.7 | CC(C)CCC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O | 10.1016/j.bmcl.2004.02.021 | |||
| 9979012 | 161265 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 411 | 7 | 1 | 5 | 4.4 | O=C(CSc1nc2ccccc2s1)NCC1CCCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(01)00176-7 | |||
| CHEMBL21199 | 161265 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 411 | 7 | 1 | 5 | 4.4 | O=C(CSc1nc2ccccc2s1)NCC1CCCN(Cc2ccccc2)C1 | 10.1016/s0960-894x(01)00176-7 | |||
| 44453198 | 195981 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 516 | 4 | 1 | 4 | 5.2 | CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2c(Cl)cccc2Cl)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL257853 | 195981 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 516 | 4 | 1 | 4 | 5.2 | CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2c(Cl)cccc2Cl)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 44309222 | 329022 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 414 | 10 | 3 | 5 | 2.9 | CC[C@H](C)[C@H](NC(=O)c1cnc2ccccc2n1)[C@@H](O)C[C@@H](CC(C)C)C(=O)NC | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL420924 | 329022 | 0 | None | None | None | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 414 | 10 | 3 | 5 | 2.9 | CC[C@H](C)[C@H](NC(=O)c1cnc2ccccc2n1)[C@@H](O)C[C@@H](CC(C)C)C(=O)NC | 10.1016/j.bmcl.2004.02.021 | |||
| 57889002 | 164286 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 382 | 5 | 1 | 2 | 4.0 | CC(C)C(NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(F)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180533 | 164286 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 382 | 5 | 1 | 2 | 4.0 | CC(C)C(NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(F)cc2)CC1 | 10.1021/jm300896d | |||
| 59444291 | 348210 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 477 | 6 | 3 | 4 | 3.0 | CC(=O)N[C@@H]1CC[C@@H](C(=O)N[C@H](C)CC(=O)N2CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C2)C1 | nan | |||
| CHEMBL4546558 | 348210 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 477 | 6 | 3 | 4 | 3.0 | CC(=O)N[C@@H]1CC[C@@H](C(=O)N[C@H](C)CC(=O)N2CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C2)C1 | nan | |||
| 44453199 | 196031 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 7 | 2 | 4 | 3.3 | Cc1ccc(S(=O)(=O)NCCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL258064 | 196031 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 422 | 7 | 2 | 4 | 3.3 | Cc1ccc(S(=O)(=O)NCCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1 | 10.1016/j.bmcl.2007.09.068 | |||
| 44453466 | 311588 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 486 | 4 | 1 | 4 | 4.3 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)c(F)c3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL404757 | 311588 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 486 | 4 | 1 | 4 | 4.3 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)c(F)c3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 44453639 | 314727 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 482 | 4 | 1 | 4 | 4.4 | Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL409498 | 314727 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 482 | 4 | 1 | 4 | 4.4 | Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | |||
| 25231302 | 350961 | 0 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 435 | 6 | 2 | 3 | 4.0 | O=C([C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1)N(CCO)Cc1ccccc1Cl | 10.1021/jm801416q | |||
| CHEMBL462650 | 350961 | 0 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 435 | 6 | 2 | 3 | 4.0 | O=C([C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1)N(CCO)Cc1ccccc1Cl | 10.1021/jm801416q | |||
| 44431528 | 291925 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 541 | 9 | 1 | 7 | 2.5 | COS(=O)(=O)NC(=O)Cc1cc(Cl)ccc1OCC(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2007.03.037 | |||
| CHEMBL391239 | 291925 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 541 | 9 | 1 | 7 | 2.5 | COS(=O)(=O)NC(=O)Cc1cc(Cl)ccc1OCC(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C | 10.1016/j.bmcl.2007.03.037 | |||
| 24758517 | 164214 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 430 | 6 | 1 | 2 | 4.6 | CC(C)[C@@H](NC(=O)Cc1cccc(F)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180187 | 164214 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 430 | 6 | 1 | 2 | 4.6 | CC(C)[C@@H](NC(=O)Cc1cccc(F)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 44453501 | 198109 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 512 | 4 | 1 | 4 | 4.2 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Br)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL271903 | 198109 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 512 | 4 | 1 | 4 | 4.2 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Br)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 44309244 | 202162 | 0 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 516 | 9 | 3 | 5 | 4.7 | CC1(C)CC([C@H](C[C@H](O)[C@H](Cc2ccccc2)NC(=O)c2cnc3ccccc3n2)C(N)=O)CC(C)(C)C1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL302038 | 202162 | 0 | None | None | None | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 516 | 9 | 3 | 5 | 4.7 | CC1(C)CC([C@H](C[C@H](O)[C@H](Cc2ccccc2)NC(=O)c2cnc3ccccc3n2)C(N)=O)CC(C)(C)C1 | 10.1016/j.bmcl.2004.02.021 | |||
| 24758518 | 163914 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 446 | 6 | 1 | 2 | 5.1 | CC(C)[C@@H](NC(=O)Cc1cccc(Cl)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2177135 | 163914 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 446 | 6 | 1 | 2 | 5.1 | CC(C)[C@@H](NC(=O)Cc1cccc(Cl)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 57889478 | 164249 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 412 | 6 | 1 | 2 | 4.9 | CC[C@@H](C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180493 | 164249 | 0 | None | None | None | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 412 | 6 | 1 | 2 | 4.9 | CC[C@@H](C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 70861827 | 350138 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 433 | 5 | 2 | 4 | 3.6 | CC(C)(CC(=O)N1CCC(O)(c2ccc(C#N)cc2)C(C)(C)C1)NC(=O)c1ccccc1 | nan | |||
| CHEMBL4593102 | 350138 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 433 | 5 | 2 | 4 | 3.6 | CC(C)(CC(=O)N1CCC(O)(c2ccc(C#N)cc2)C(C)(C)C1)NC(=O)c1ccccc1 | nan | |||
| 11037958 | 157630 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 465 | 6 | 1 | 5 | 5.5 | O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm300682j | |||
| CHEMBL20532 | 157630 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 465 | 6 | 1 | 5 | 5.5 | O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 | 10.1021/jm300682j | |||
| 11037958 | 157630 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 465 | 6 | 1 | 5 | 5.5 | O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 | 10.1016/s0960-894x(01)00176-7 | |||
| CHEMBL20532 | 157630 | 0 | None | None | None | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 465 | 6 | 1 | 5 | 5.5 | O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 | 10.1016/s0960-894x(01)00176-7 | |||
| 57889003 | 181969 | 9 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889430 | 181969 | 9 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398726 | 181969 | 9 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398728 | 181969 | 9 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57888690 | 164259 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 376 | 6 | 1 | 2 | 4.0 | CC(C)[C@@H](NC(=O)CC1CC1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180503 | 164259 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 376 | 6 | 1 | 2 | 4.0 | CC(C)[C@@H](NC(=O)CC1CC1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 3497 | 2447 | 26 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1016/j.bmcl.2004.02.022 | |||
| 44309353 | 2447 | 26 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1016/j.bmcl.2004.02.022 | |||
| 5311123 | 2447 | 26 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1016/j.bmcl.2004.02.022 | |||
| CHEMBL1628706 | 2447 | 26 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1016/j.bmcl.2004.02.022 | |||
| CHEMBL308473 | 2447 | 26 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1016/j.bmcl.2004.02.022 | |||
| 59444274 | 350110 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 535 | 6 | 3 | 5 | 4.4 | C[C@H](CC(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)NC(=O)[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)C1 | nan | |||
| CHEMBL4592423 | 350110 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 535 | 6 | 3 | 5 | 4.4 | C[C@H](CC(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)NC(=O)[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)C1 | nan | |||
| 44453615 | 195538 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 512 | 4 | 1 | 4 | 4.2 | O=S(=O)(c1ccccc1Br)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL255797 | 195538 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 512 | 4 | 1 | 4 | 4.2 | O=S(=O)(c1ccccc1Br)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 | 10.1016/j.bmcl.2007.09.068 | |||
| 44309128 | 468981 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 422 | 10 | 4 | 6 | 1.2 | NC(=O)[C@H](CCO)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL69735 | 468981 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 422 | 10 | 4 | 6 | 1.2 | NC(=O)[C@H](CCO)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.021 | |||
| 57840515 | 177759 | 1 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 493 | 6 | 0 | 6 | 3.6 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3CN(C)C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322869 | 177759 | 1 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 493 | 6 | 0 | 6 | 3.6 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3CN(C)C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 6918497 | 232475 | 1 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL331897 | 232475 | 1 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | |||
| 25233578 | 373173 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 419 | 4 | 1 | 2 | 5.2 | CC(c1ccc(Cl)cc1)N(C)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 | 10.1021/jm801416q | |||
| CHEMBL517262 | 373173 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 419 | 4 | 1 | 2 | 5.2 | CC(c1ccc(Cl)cc1)N(C)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 | 10.1021/jm801416q | |||
| 57889613 | 182000 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 432 | 5 | 2 | 3 | 4.3 | CC(C)[C@@H](NC(=O)c1ccc(F)c(O)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398762 | 182000 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 432 | 5 | 2 | 3 | 4.3 | CC(C)[C@@H](NC(=O)c1ccc(F)c(O)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889023 | 182003 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 576 | 7 | 4 | 4 | 5.4 | CC(C)[C@@H](NC(=O)c1cccc(-c2ccccc2NC(N)=O)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398765 | 182003 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 576 | 7 | 4 | 4 | 5.4 | CC(C)[C@@H](NC(=O)c1cccc(-c2ccccc2NC(N)=O)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 44309318 | 203041 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 460 | 10 | 3 | 5 | 3.4 | NC(=O)[C@H](CC1CCCC1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL306685 | 203041 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 460 | 10 | 3 | 5 | 3.4 | NC(=O)[C@H](CC1CCCC1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.021 | |||
| 9889700 | 237386 | 15 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 444 | 7 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0004244 | |||
| CHEMBL34166 | 237386 | 15 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 444 | 7 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0004244 | |||
| 44431523 | 178924 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 468 | 11 | 4 | 6 | 3.0 | CC(C)(O)CC[C@@H](CN)C[C@H](O)[C@H](Cc1cccc(F)c1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2007.03.037 | |||
| CHEMBL234606 | 178924 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 468 | 11 | 4 | 6 | 3.0 | CC(C)(O)CC[C@@H](CN)C[C@H](O)[C@H](Cc1cccc(F)c1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2007.03.037 | |||
| 602123 | 174772 | 48 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 236 | 2 | 0 | 4 | 2.4 | O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 | 10.1021/jm301121j | |||
| CHEMBL2205803 | 174772 | 48 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 236 | 2 | 0 | 4 | 2.4 | O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 | 10.1021/jm301121j | |||
| 68962095 | 181597 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 500 | 6 | 2 | 6 | 3.1 | Cc1ccc(C(=O)N2CC[C@H](O)C2)c(OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)c1 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391799 | 181597 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 500 | 6 | 2 | 6 | 3.1 | Cc1ccc(C(=O)N2CC[C@H](O)C2)c(OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)c1 | 10.1016/j.bmcl.2013.04.047 | |||
| 57840437 | 177747 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 434 | 4 | 0 | 5 | 3.4 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(F)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322858 | 177747 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 434 | 4 | 0 | 5 | 3.4 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(F)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 71717436 | 177769 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 468 | 4 | 0 | 5 | 4.0 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(F)c1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322879 | 177769 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 468 | 4 | 0 | 5 | 4.0 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(F)c1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 10579693 | 25448 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 489 | 7 | 1 | 2 | 7.2 | CCCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1178558 | 25448 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 489 | 7 | 1 | 2 | 7.2 | CCCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| 44537841 | 1390 | 22 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| 57889181 | 1390 | 22 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| 9497 | 1390 | 22 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398716 | 1390 | 22 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL3334824 | 1390 | 22 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1016/j.bmcl.2013.04.079 | |||
| 9894714 | 26260 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 461 | 5 | 1 | 2 | 6.4 | CC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1183117 | 26260 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 461 | 5 | 1 | 2 | 6.4 | CC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| 52916803 | 335526 | 28 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 451 | 5 | 1 | 7 | 2.8 | CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 | 10.6019/CHEMBL5210307 | |||
| CHEMBL4456123 | 335526 | 28 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 451 | 5 | 1 | 7 | 2.8 | CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 | 10.6019/CHEMBL5210307 | |||
| 52916803 | 335526 | 28 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 451 | 5 | 1 | 7 | 2.8 | CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 | 10.6019/CHEMBL4507278 | |||
| CHEMBL4456123 | 335526 | 28 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 451 | 5 | 1 | 7 | 2.8 | CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 | 10.6019/CHEMBL4507278 | |||
| 44537841 | 1390 | 22 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 57889181 | 1390 | 22 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 9497 | 1390 | 22 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL2398716 | 1390 | 22 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL3334824 | 1390 | 22 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 57888895 | 181971 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 476 | 5 | 2 | 3 | 4.9 | CC(C)[C@@H](NC(=O)c1ccc(Cl)cc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398730 | 181971 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 476 | 5 | 2 | 3 | 4.9 | CC(C)[C@@H](NC(=O)c1ccc(Cl)cc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 512282 | 1562 | 44 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1021/jm801416q | |||
| 767 | 1562 | 44 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1021/jm801416q | |||
| CHEMBL232656 | 1562 | 44 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1021/jm801416q | |||
| 71681399 | 181967 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 449 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CCC[C@@H]1N)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398724 | 181967 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 449 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CCC[C@@H]1N)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 10482996 | 214047 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 449 | 6 | 3 | 5 | 3.2 | NC(=O)Nc1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.11.062 | |||
| CHEMBL3099950 | 214047 | 0 | None | None | None | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 449 | 6 | 3 | 5 | 3.2 | NC(=O)Nc1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.11.062 | |||
| 57889758 | 181979 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 470 | 7 | 2 | 3 | 4.6 | CC(C)[C@@H](NC(=O)CCc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398738 | 181979 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 470 | 7 | 2 | 3 | 4.6 | CC(C)[C@@H](NC(=O)CCc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 6918497 | 232475 | 1 | None | None | None | Mouse | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL331897 | 232475 | 1 | None | None | None | Mouse | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | |||
| 6918497 | 232475 | 1 | None | None | None | Mouse | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL331897 | 232475 | 1 | None | None | None | Mouse | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | |||
| 11236656 | 177758 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 3.0 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3CN)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322868 | 177758 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 3.0 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3CN)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 24782574 | 353253 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 453 | 4 | 1 | 2 | 5.3 | Cc1cc(C(F)(F)F)ccc1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1 | 10.1021/jm801416q | |||
| CHEMBL473734 | 353253 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 453 | 4 | 1 | 2 | 5.3 | Cc1cc(C(F)(F)F)ccc1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1 | 10.1021/jm801416q | |||
| 24758744 | 164251 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 398 | 6 | 1 | 2 | 4.2 | CC[C@@H](NC(=O)Cc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180495 | 164251 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 398 | 6 | 1 | 2 | 4.2 | CC[C@@H](NC(=O)Cc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 44430753 | 279194 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 598 | 11 | 3 | 9 | 2.2 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL387608 | 279194 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 598 | 11 | 3 | 9 | 2.2 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 57840557 | 177752 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 473 | 5 | 1 | 6 | 3.2 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(NC(C)=O)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322862 | 177752 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 473 | 5 | 1 | 6 | 3.2 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(NC(C)=O)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 44453292 | 311437 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 448 | 4 | 1 | 4 | 3.8 | Cc1ccccc1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL404033 | 311437 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 448 | 4 | 1 | 4 | 3.8 | Cc1ccccc1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 11072275 | 40680 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 632 | 10 | 3 | 5 | 5.9 | COC(=O)N1CCC(NC(=O)NCC(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm0201767 | |||
| CHEMBL124585 | 40680 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 632 | 10 | 3 | 5 | 5.9 | COC(=O)N1CCC(NC(=O)NCC(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm0201767 | |||
| 9889700 | 237386 | 15 | None | None | None | Mouse | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 444 | 7 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0004244 | |||
| CHEMBL34166 | 237386 | 15 | None | None | None | Mouse | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 444 | 7 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0004244 | |||
| 602123 | 174772 | 48 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 236 | 2 | 0 | 4 | 2.4 | O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 | 10.1021/jm301121j | |||
| CHEMBL2205803 | 174772 | 48 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 236 | 2 | 0 | 4 | 2.4 | O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 | 10.1021/jm301121j | |||
| 77865 | 216919 | 57 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 214 | 0 | 0 | 2 | 3.4 | Clc1cc2cccnc2c2ncccc12 | 10.1021/jm301121j | |||
| CHEMBL317115 | 216919 | 57 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 214 | 0 | 0 | 2 | 3.4 | Clc1cc2cccnc2c2ncccc12 | 10.1021/jm301121j | |||
| 10670301 | 233135 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 430 | 4 | 1 | 3 | 5.8 | O=C(NC1CCN(C/C2=C/CCCCCC2)CC1)C1c2ccccc2Oc2ccccc21 | 10.1021/jm0004244 | |||
| CHEMBL33277 | 233135 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 430 | 4 | 1 | 3 | 5.8 | O=C(NC1CCN(C/C2=C/CCCCCC2)CC1)C1c2ccccc2Oc2ccccc21 | 10.1021/jm0004244 | |||
| 44453469 | 196095 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1Cl | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL258360 | 196095 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1Cl | 10.1016/j.bmcl.2007.09.068 | |||
| 44453499 | 311371 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 486 | 4 | 1 | 4 | 4.3 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL403613 | 311371 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 486 | 4 | 1 | 4 | 4.3 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 44309236 | 468643 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 475 | 10 | 3 | 4 | 3.3 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cncc(Br)c1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL67256 | 468643 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 475 | 10 | 3 | 4 | 3.3 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cncc(Br)c1 | 10.1016/j.bmcl.2004.02.021 | |||
| 11794863 | 237676 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 392 | 7 | 1 | 3 | 5.1 | CCCCCCN1CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1016/j.ejmech.2020.113085 | |||
| CHEMBL34226 | 237676 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 392 | 7 | 1 | 3 | 5.1 | CCCCCCN1CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1016/j.ejmech.2020.113085 | |||
| 11794863 | 237676 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 392 | 7 | 1 | 3 | 5.1 | CCCCCCN1CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL34226 | 237676 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 392 | 7 | 1 | 3 | 5.1 | CCCCCCN1CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| 77865 | 216919 | 57 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 214 | 0 | 0 | 2 | 3.4 | Clc1cc2cccnc2c2ncccc12 | 10.1021/jm301121j | |||
| CHEMBL317115 | 216919 | 57 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 214 | 0 | 0 | 2 | 3.4 | Clc1cc2cccnc2c2ncccc12 | 10.1021/jm301121j | |||
| 10793529 | 219313 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 588 | 4 | 1 | 3 | 7.4 | O=C(NC1CCN(CC2CCCCCCC2)CC1)C1c2cc(Br)ccc2Oc2ccc(Br)cc21 | 10.1021/jm0004244 | |||
| CHEMBL32305 | 219313 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 588 | 4 | 1 | 3 | 7.4 | O=C(NC1CCN(CC2CCCCCCC2)CC1)C1c2cc(Br)ccc2Oc2ccc(Br)cc21 | 10.1021/jm0004244 | |||
| 44453197 | 311380 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 482 | 4 | 1 | 4 | 4.5 | CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2ccccc2Cl)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL403665 | 311380 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 482 | 4 | 1 | 4 | 4.5 | CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2ccccc2Cl)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 44309112 | 468910 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 447 | 10 | 3 | 4 | 3.7 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cncc2ccccc12 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL69285 | 468910 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 447 | 10 | 3 | 4 | 3.7 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cncc2ccccc12 | 10.1016/j.bmcl.2004.02.021 | |||
| 71719856 | 177773 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 493 | 5 | 1 | 6 | 3.0 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(C(N)=O)c1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322883 | 177773 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 493 | 5 | 1 | 6 | 3.0 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(C(N)=O)c1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 44309313 | 202594 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | CC(C)(O)CCC(C[C@H](O)[C@H](Cc1ccccc1F)NC(=O)c1cnc2ccccc2n1)C(N)=O | 10.1016/j.bmcl.2004.02.022 | |||
| CHEMBL304053 | 202594 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | CC(C)(O)CCC(C[C@H](O)[C@H](Cc1ccccc1F)NC(=O)c1cnc2ccccc2n1)C(N)=O | 10.1016/j.bmcl.2004.02.022 | |||
| 57840210 | 177740 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 426 | 5 | 1 | 6 | 2.6 | COc1cc(N2CCN(C(=O)Cn3nc(C(=O)O)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322851 | 177740 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 426 | 5 | 1 | 6 | 2.6 | COc1cc(N2CCN(C(=O)Cn3nc(C(=O)O)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 57889880 | 164300 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 414 | 6 | 2 | 3 | 3.7 | CCCC(NC(=O)c1ccccc1)C(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180549 | 164300 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 414 | 6 | 2 | 3 | 3.7 | CCCC(NC(=O)c1ccccc1)C(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 24740167 | 164287 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 399 | 5 | 1 | 3 | 3.4 | CC(C)C(NC(=O)c1ccccc1)C(=O)N1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180535 | 164287 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 399 | 5 | 1 | 3 | 3.4 | CC(C)C(NC(=O)c1ccccc1)C(=O)N1CCN(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 57889006 | 164302 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 446 | 7 | 2 | 4 | 3.7 | CSCCC(NC(=O)c1ccccc1)C(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180551 | 164302 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 446 | 7 | 2 | 4 | 3.7 | CSCCC(NC(=O)c1ccccc1)C(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 57889003 | 181969 | 9 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889430 | 181969 | 9 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398726 | 181969 | 9 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398728 | 181969 | 9 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 25233947 | 348330 | 5 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 435 | 6 | 2 | 3 | 4.0 | O=C([C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1)N(CCO)Cc1ccc(Cl)cc1 | 10.1021/jm801416q | |||
| CHEMBL454940 | 348330 | 5 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 435 | 6 | 2 | 3 | 4.0 | O=C([C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1)N(CCO)Cc1ccc(Cl)cc1 | 10.1021/jm801416q | |||
| 44453435 | 197904 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)ccc1Cl | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL270863 | 197904 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)ccc1Cl | 10.1016/j.bmcl.2007.09.068 | |||
| 44309407 | 203014 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 476 | 9 | 4 | 6 | 2.5 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1(O)CCCCC1 | 10.1016/j.bmcl.2004.02.022 | |||
| CHEMBL306457 | 203014 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 476 | 9 | 4 | 6 | 2.5 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1(O)CCCCC1 | 10.1016/j.bmcl.2004.02.022 | |||
| 57889346 | 164276 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 441 | 7 | 2 | 2 | 4.6 | CC(C)[C@@H](NC(=O)NCCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180522 | 164276 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 441 | 7 | 2 | 2 | 4.6 | CC(C)[C@@H](NC(=O)NCCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 24758044 | 164277 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 57888953 | 164277 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 71455572 | 164277 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180523 | 164277 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180528 | 164277 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180534 | 164277 | 0 | None | None | None | Human | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 24758044 | 164277 | 0 | None | None | None | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 57888953 | 164277 | 0 | None | None | None | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 71455572 | 164277 | 0 | None | None | None | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180523 | 164277 | 0 | None | None | None | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180528 | 164277 | 0 | None | None | None | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180534 | 164277 | 0 | None | None | None | Rabbit | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 44309061 | 328574 | 0 | None | None | None | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 449 | 11 | 3 | 6 | 1.8 | CN(C)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL420359 | 328574 | 0 | None | None | None | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 449 | 11 | 3 | 6 | 1.8 | CN(C)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O | 10.1016/j.bmcl.2004.02.021 | |||
| 69437285 | 214051 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 457 | 5 | 3 | 6 | 2.1 | O=c1[nH]c(=O)c2cccc(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)c2[nH]1 | 10.1016/j.bmcl.2013.11.062 | |||
| CHEMBL3099954 | 214051 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 457 | 5 | 3 | 6 | 2.1 | O=c1[nH]c(=O)c2cccc(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)c2[nH]1 | 10.1016/j.bmcl.2013.11.062 | |||
| 68816399 | 214056 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 423 | 5 | 2 | 5 | 2.8 | N[C@H](COc1cccc2ccc(=O)[nH]c12)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | 10.1016/j.bmcl.2013.11.062 | |||
| CHEMBL3099959 | 214056 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 423 | 5 | 2 | 5 | 2.8 | N[C@H](COc1cccc2ccc(=O)[nH]c12)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | 10.1016/j.bmcl.2013.11.062 | |||
| 44309219 | 202205 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 512 | 9 | 4 | 6 | 2.8 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1(O)CCC(F)(F)CC1 | 10.1016/j.bmcl.2004.02.022 | |||
| CHEMBL302320 | 202205 | 0 | None | None | None | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 512 | 9 | 4 | 6 | 2.8 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1(O)CCC(F)(F)CC1 | 10.1016/j.bmcl.2004.02.022 | |||
| 21071066 | 177779 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 386 | 3 | 0 | 4 | 3.2 | Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccccc2)CC1 | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322889 | 177779 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 386 | 3 | 0 | 4 | 3.2 | Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccccc2)CC1 | 10.1016/j.bmcl.2013.01.005 | |||
| 44309077 | 469245 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 549 | 11 | 2 | 6 | 3.6 | CN1CCN(C(=O)C(CCC(C)(C)F)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)c2cnc3ccccc3n2)CC1 | 10.1016/j.bmcl.2004.02.022 | |||
| CHEMBL71499 | 469245 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 549 | 11 | 2 | 6 | 3.6 | CN1CCN(C(=O)C(CCC(C)(C)F)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)c2cnc3ccccc3n2)CC1 | 10.1016/j.bmcl.2004.02.022 | |||
| 21071098 | 177826 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 431 | 4 | 0 | 6 | 3.1 | Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc([N+](=O)[O-])cc2)CC1 | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2323420 | 177826 | 0 | None | None | None | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 431 | 4 | 0 | 6 | 3.1 | Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc([N+](=O)[O-])cc2)CC1 | 10.1016/j.bmcl.2013.01.005 | |||
| 44453528 | 197843 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 414 | 7 | 2 | 5 | 3.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccsc1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL270564 | 197843 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 414 | 7 | 2 | 5 | 3.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccsc1 | 10.1016/j.bmcl.2007.09.068 | |||
| 25231481 | 350960 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 385 | 4 | 1 | 2 | 4.3 | Cc1ccc(CN(C)C(=O)[C@H]2CCCN2C(=O)Nc2ccc(Cl)cc2)cc1 | 10.1021/jm801416q | |||
| CHEMBL462644 | 350960 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 385 | 4 | 1 | 2 | 4.3 | Cc1ccc(CN(C)C(=O)[C@H]2CCCN2C(=O)Nc2ccc(Cl)cc2)cc1 | 10.1021/jm801416q | |||
| 24758175 | 164223 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 454 | 5 | 1 | 3 | 5.7 | CC(C)[C@@H](NC(=O)c1cc2ccccc2s1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180196 | 164223 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 454 | 5 | 1 | 3 | 5.7 | CC(C)[C@@H](NC(=O)c1cc2ccccc2s1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 44453228 | 195769 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 426 | 7 | 2 | 4 | 3.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1F | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL256888 | 195769 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 426 | 7 | 2 | 4 | 3.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1F | 10.1016/j.bmcl.2007.09.068 | |||
| 44309235 | 202206 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 447 | 10 | 3 | 4 | 3.7 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1nccc2ccccc12 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL302328 | 202206 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 447 | 10 | 3 | 4 | 3.7 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1nccc2ccccc12 | 10.1016/j.bmcl.2004.02.021 | |||
| 44309194 | 468546 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 464 | 11 | 4 | 6 | 2.4 | CC(C)(O)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O | 10.1016/j.bmcl.2004.02.022 | |||
| CHEMBL66457 | 468546 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 464 | 11 | 4 | 6 | 2.4 | CC(C)(O)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O | 10.1016/j.bmcl.2004.02.022 | |||
| 25174628 | 258178 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 498 | 5 | 3 | 4 | 4.2 | CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)[C@H](O)c2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| 25174629 | 258178 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 498 | 5 | 3 | 4 | 4.2 | CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)[C@H](O)c2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL3679648 | 258178 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 498 | 5 | 3 | 4 | 4.2 | CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)[C@H](O)c2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL3679649 | 258178 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 498 | 5 | 3 | 4 | 4.2 | CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)[C@H](O)c2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| 44453084 | 195641 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 422 | 6 | 2 | 3 | 4.6 | O=C(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL256264 | 195641 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 422 | 6 | 2 | 3 | 4.6 | O=C(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 | 10.1016/j.bmcl.2007.09.068 | |||
| 11166434 | 292014 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 434 | 6 | 1 | 4 | 3.7 | C[C@H]1CN(C(=O)COc2ccc(Cl)cc2C(=O)O)[C@H](C)CN1Cc1ccc(F)cc1 | 10.1016/j.bmcl.2007.03.037 | |||
| CHEMBL391301 | 292014 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 434 | 6 | 1 | 4 | 3.7 | C[C@H]1CN(C(=O)COc2ccc(Cl)cc2C(=O)O)[C@H](C)CN1Cc1ccc(F)cc1 | 10.1016/j.bmcl.2007.03.037 | |||
| 10670301 | 233135 | 0 | None | None | None | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 430 | 4 | 1 | 3 | 5.8 | O=C(NC1CCN(C/C2=C/CCCCCC2)CC1)C1c2ccccc2Oc2ccccc21 | 10.1021/jm0004244 | |||
| CHEMBL33277 | 233135 | 0 | None | None | None | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 430 | 4 | 1 | 3 | 5.8 | O=C(NC1CCN(C/C2=C/CCCCCC2)CC1)C1c2ccccc2Oc2ccccc21 | 10.1021/jm0004244 | |||
| 44537841 | 1390 | 22 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 57889181 | 1390 | 22 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 9497 | 1390 | 22 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL2398716 | 1390 | 22 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL3334824 | 1390 | 22 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 57888785 | 233482 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 465 | 5 | 4 | 4 | 3.0 | CC(C)[C@@H](NC(=O)N[C@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| CHEMBL3334815 | 233482 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 465 | 5 | 4 | 4 | 3.0 | CC(C)[C@@H](NC(=O)N[C@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| 57889188 | 233483 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 437 | 6 | 3 | 3 | 3.9 | CC[C@@H](C)NC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL3334816 | 233483 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 437 | 6 | 3 | 3 | 3.9 | CC[C@@H](C)NC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | 10.1021/jm5003167 | |||
| 118714037 | 233490 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 439 | 6 | 4 | 4 | 2.5 | CC(C)[C@@H](NC(=O)NC[C@@H](C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| CHEMBL3334823 | 233490 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 439 | 6 | 4 | 4 | 2.5 | CC(C)[C@@H](NC(=O)NC[C@@H](C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| 57840302 | 177751 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 441 | 4 | 0 | 6 | 3.1 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(C#N)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322861 | 177751 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 441 | 4 | 0 | 6 | 3.1 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(C#N)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 21070989 | 177765 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322875 | 177765 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 11397004 | 178228 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 459 | 7 | 2 | 6 | 3.5 | COc1ccc(NC(C)=O)c(OC[C@@H](N)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)c1 | 10.1016/j.bmcl.2012.12.095 | |||
| CHEMBL2332937 | 178228 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 459 | 7 | 2 | 6 | 3.5 | COc1ccc(NC(C)=O)c(OC[C@@H](N)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)c1 | 10.1016/j.bmcl.2012.12.095 | |||
| 57889979 | 181976 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 443 | 5 | 2 | 4 | 3.6 | CC(C)[C@@H](NC(=O)c1cccnc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398735 | 181976 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 443 | 5 | 2 | 4 | 3.6 | CC(C)[C@@H](NC(=O)c1cccnc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57888919 | 181970 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57889974 | 181970 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398727 | 181970 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398729 | 181970 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 450 | 5 | 3 | 4 | 3.1 | CC(C)[C@@H](NC(=O)[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57888747 | 182008 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 476 | 5 | 2 | 3 | 4.9 | CC(C)[C@@H](NC(=O)c1ccccc1Cl)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398770 | 182008 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 476 | 5 | 2 | 3 | 4.9 | CC(C)[C@@H](NC(=O)c1ccccc1Cl)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 10030344 | 214046 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 431 | 6 | 3 | 5 | 3.0 | NC(=O)Nc1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.11.062 | |||
| CHEMBL3099949 | 214046 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 431 | 6 | 3 | 5 | 3.0 | NC(=O)Nc1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.11.062 | |||
| 57889484 | 182002 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 532 | 7 | 3 | 3 | 5.7 | CC(C)[C@@H](NC(=O)c1cccc(-c2ccccc2NC(N)=O)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398764 | 182002 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 532 | 7 | 3 | 3 | 5.7 | CC(C)[C@@H](NC(=O)c1cccc(-c2ccccc2NC(N)=O)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| 44453584 | 198222 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 484 | 8 | 2 | 4 | 4.7 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1ccccc1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL272523 | 198222 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 484 | 8 | 2 | 4 | 4.7 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1ccccc1 | 10.1016/j.bmcl.2007.09.068 | |||
| 44453557 | 311501 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 451 | 7 | 1 | 4 | 4.2 | N#CC1(c2ccc(Cl)cc2)CCN(CCCNS(=O)(=O)c2ccccc2Cl)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL404301 | 311501 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 451 | 7 | 1 | 4 | 4.2 | N#CC1(c2ccc(Cl)cc2)CCN(CCCNS(=O)(=O)c2ccccc2Cl)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 44309192 | 203231 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 464 | 10 | 4 | 6 | 2.8 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccc(O)cc1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL308209 | 203231 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 464 | 10 | 4 | 6 | 2.8 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccc(O)cc1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.021 | |||
| 512282 | 1562 | 44 | None | None | None | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2007.03.104 | |||
| 767 | 1562 | 44 | None | None | None | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL232656 | 1562 | 44 | None | None | None | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1016/j.bmcl.2007.03.104 | |||
| 44430713 | 177592 | 0 | None | None | None | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 500 | 8 | 2 | 7 | 3.0 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL231829 | 177592 | 0 | None | None | None | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 500 | 8 | 2 | 7 | 3.0 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 57888949 | 164274 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 413 | 5 | 2 | 2 | 4.9 | CC(C)[C@@H](NC(=O)Nc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180520 | 164274 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 413 | 5 | 2 | 2 | 4.9 | CC(C)[C@@H](NC(=O)Nc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 44430745 | 279221 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 544 | 11 | 2 | 8 | 3.0 | COCCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL387822 | 279221 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 544 | 11 | 2 | 8 | 3.0 | COCCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 10698568 | 25460 | 0 | None | None | None | Mouse | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 459 | 5 | 1 | 2 | 6.3 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1178613 | 25460 | 0 | None | None | None | Mouse | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 459 | 5 | 1 | 2 | 6.3 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| 9889700 | 237386 | 15 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 444 | 7 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | |||
| CHEMBL34166 | 237386 | 15 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 444 | 7 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | |||
| 44537841 | 1390 | 22 | None | None | None | Dog | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 57889181 | 1390 | 22 | None | None | None | Dog | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 9497 | 1390 | 22 | None | None | None | Dog | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL2398716 | 1390 | 22 | None | None | None | Dog | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL3334824 | 1390 | 22 | None | None | None | Dog | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 44430750 | 178130 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 583 | 11 | 2 | 8 | 3.4 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCCC2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL233042 | 178130 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 583 | 11 | 2 | 8 | 3.4 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCCC2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 44309074 | 468824 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 448 | 10 | 3 | 5 | 3.1 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL68581 | 468824 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 448 | 10 | 3 | 5 | 3.1 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.021 | |||
| 58778007 | 177827 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 464 | 4 | 0 | 6 | 2.6 | Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(S(C)(=O)=O)cc2)CC1 | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2323421 | 177827 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 464 | 4 | 0 | 6 | 2.6 | Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(S(C)(=O)=O)cc2)CC1 | 10.1016/j.bmcl.2013.01.005 | |||
| 49865900 | 40073 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 448 | 4 | 1 | 3 | 6.0 | O=C(Nc1ccc(C(F)(F)F)cc1)N1CCCC1c1nccn1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.07.082 | |||
| CHEMBL1224118 | 40073 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 448 | 4 | 1 | 3 | 6.0 | O=C(Nc1ccc(C(F)(F)F)cc1)N1CCCC1c1nccn1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.07.082 | |||
| 10049290 | 468931 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 447 | 10 | 3 | 4 | 3.7 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.020 | |||
| 10049290 | 468931 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 447 | 10 | 3 | 4 | 3.7 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL69411 | 468931 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 447 | 10 | 3 | 4 | 3.7 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.020 | |||
| CHEMBL69411 | 468931 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 447 | 10 | 3 | 4 | 3.7 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2c1 | 10.1016/j.bmcl.2004.02.021 | |||
| 71453837 | 164256 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 440 | 8 | 1 | 2 | 5.2 | CC[C@@H](C)[C@@H](NC(=O)CCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180500 | 164256 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 440 | 8 | 1 | 2 | 5.2 | CC[C@@H](C)[C@@H](NC(=O)CCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 9894714 | 26260 | 0 | None | None | None | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 461 | 5 | 1 | 2 | 6.4 | CC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1183117 | 26260 | 0 | None | None | None | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 461 | 5 | 1 | 2 | 6.4 | CC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| 11813735 | 236969 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 562 | 12 | 3 | 4 | 5.3 | CN(C)CCNC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | |||
| CHEMBL340797 | 236969 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 562 | 12 | 3 | 4 | 5.3 | CN(C)CCNC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | |||
| 44309185 | 469298 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 454 | 10 | 3 | 5 | 3.9 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL71903 | 469298 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 454 | 10 | 3 | 5 | 3.9 | CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.021 | |||
| 10555551 | 25450 | 0 | None | None | None | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 473 | 6 | 1 | 2 | 6.6 | C=CC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1178575 | 25450 | 0 | None | None | None | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 473 | 6 | 1 | 2 | 6.6 | C=CC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| 71570634 | 178233 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 411 | 6 | 3 | 6 | 2.5 | CC(=O)Nc1ccc(O)cc1OC[C@@H](N)CN1CCC2(CC1)Cc1ccccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| CHEMBL2332942 | 178233 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 411 | 6 | 3 | 6 | 2.5 | CC(=O)Nc1ccc(O)cc1OC[C@@H](N)CN1CCC2(CC1)Cc1ccccc1O2 | 10.1016/j.bmcl.2012.12.095 | |||
| 57840380 | 177760 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 507 | 6 | 1 | 6 | 3.2 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3CNC(C)=O)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322870 | 177760 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 507 | 6 | 1 | 6 | 3.2 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3CNC(C)=O)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 25233579 | 350838 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 385 | 4 | 1 | 2 | 4.3 | Cc1ccc(NC(=O)N2CCC[C@@H]2C(=O)N(C)Cc2ccc(Cl)cc2)cc1 | 10.1021/jm801416q | |||
| CHEMBL461590 | 350838 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 385 | 4 | 1 | 2 | 4.3 | Cc1ccc(NC(=O)N2CCC[C@@H]2C(=O)N(C)Cc2ccc(Cl)cc2)cc1 | 10.1021/jm801416q | |||
| 44453363 | 197829 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 458 | 7 | 2 | 4 | 4.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL270433 | 197829 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 458 | 7 | 2 | 4 | 4.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc2ccccc12 | 10.1016/j.bmcl.2007.09.068 | |||
| 49865951 | 40089 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 463 | 4 | 1 | 4 | 5.7 | Cc1nnc([C@H]2CCCN2C(=O)Nc2ccc(C(F)(F)F)cc2)n1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.07.082 | |||
| CHEMBL1224189 | 40089 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 463 | 4 | 1 | 4 | 5.7 | Cc1nnc([C@H]2CCCN2C(=O)Nc2ccc(C(F)(F)F)cc2)n1Cc1ccc(Cl)cc1 | 10.1016/j.bmcl.2010.07.082 | |||
| 118714035 | 233488 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 439 | 6 | 4 | 4 | 2.5 | CC(C)[C@@H](NC(=O)NC[C@H](C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| CHEMBL3334821 | 233488 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 439 | 6 | 4 | 4 | 2.5 | CC(C)[C@@H](NC(=O)NC[C@H](C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| 57840482 | 177750 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 542 | 4 | 0 | 5 | 3.8 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(I)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322860 | 177750 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 542 | 4 | 0 | 5 | 3.8 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(I)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 44430758 | 279954 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 482 | 6 | 2 | 6 | 3.1 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1Nc1c(N)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL389293 | 279954 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 482 | 6 | 2 | 6 | 3.1 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1Nc1c(N)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 44309286 | 202416 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 512 | 9 | 4 | 6 | 3.7 | O=C(N[C@@H](Cc1ccccc1)[C@@H](O)CC(C(=O)NO)C1CCC(F)(F)CC1)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.022 | |||
| CHEMBL303673 | 202416 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 512 | 9 | 4 | 6 | 3.7 | O=C(N[C@@H](Cc1ccccc1)[C@@H](O)CC(C(=O)NO)C1CCC(F)(F)CC1)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.022 | |||
| 44309143 | 468504 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 481 | 11 | 4 | 6 | 2.9 | CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NN | 10.1016/j.bmcl.2004.02.022 | |||
| CHEMBL66159 | 468504 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 481 | 11 | 4 | 6 | 2.9 | CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NN | 10.1016/j.bmcl.2004.02.022 | |||
| 68956901 | 181607 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 500 | 6 | 2 | 6 | 3.9 | O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCCCC1 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391809 | 181607 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 500 | 6 | 2 | 6 | 3.9 | O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCCCC1 | 10.1016/j.bmcl.2013.04.047 | |||
| 57889649 | 181974 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 486 | 6 | 3 | 4 | 3.9 | CC(C)[C@@H](NC(=O)c1cccc(C(=O)O)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398733 | 181974 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 486 | 6 | 3 | 4 | 3.9 | CC(C)[C@@H](NC(=O)c1cccc(C(=O)O)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 69435853 | 214048 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 444 | 5 | 2 | 6 | 2.9 | O=C1COc2cccc(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)c2N1 | 10.1016/j.bmcl.2013.11.062 | |||
| CHEMBL3099951 | 214048 | 0 | None | None | None | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 444 | 5 | 2 | 6 | 2.9 | O=C1COc2cccc(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)c2N1 | 10.1016/j.bmcl.2013.11.062 | |||
| 73350585 | 181962 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 441 | 5 | 2 | 4 | 3.4 | CC(C)[C@@H](NC(=O)c1cccnc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C2(CC2)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398718 | 181962 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 441 | 5 | 2 | 4 | 3.4 | CC(C)[C@@H](NC(=O)c1cccnc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C2(CC2)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 44537841 | 1390 | 22 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 57889181 | 1390 | 22 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 9497 | 1390 | 22 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL2398716 | 1390 | 22 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL3334824 | 1390 | 22 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 57889291 | 181977 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 443 | 5 | 2 | 4 | 3.6 | CC(C)[C@@H](NC(=O)c1ccncc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398736 | 181977 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 443 | 5 | 2 | 4 | 3.6 | CC(C)[C@@H](NC(=O)c1ccncc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 10368788 | 181594 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 502 | 6 | 3 | 7 | 2.5 | O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@@H](O)C1 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391796 | 181594 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 502 | 6 | 3 | 7 | 2.5 | O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@@H](O)C1 | 10.1016/j.bmcl.2013.04.047 | |||
| 11764610 | 181604 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 516 | 7 | 2 | 7 | 3.1 | CO[C@H]1CCN(C(=O)c2ccc(O)cc2OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)C1 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391806 | 181604 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 516 | 7 | 2 | 7 | 3.1 | CO[C@H]1CCN(C(=O)c2ccc(O)cc2OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)C1 | 10.1016/j.bmcl.2013.04.047 | |||
| 57889883 | 164220 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 444 | 7 | 1 | 2 | 5.0 | CC(C)[C@@H](NC(=O)CCc1ccc(F)cc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180193 | 164220 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 444 | 7 | 1 | 2 | 5.0 | CC(C)[C@@H](NC(=O)CCc1ccc(F)cc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 24758047 | 164257 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 390 | 5 | 1 | 2 | 4.4 | CC(C)[C@@H](NC(=O)C1CCCC1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180501 | 164257 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 390 | 5 | 1 | 2 | 4.4 | CC(C)[C@@H](NC(=O)C1CCCC1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 25233580 | 372935 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 389 | 4 | 1 | 2 | 4.1 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(F)cc1 | 10.1021/jm801416q | |||
| CHEMBL516495 | 372935 | 0 | None | None | None | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 389 | 4 | 1 | 2 | 4.1 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(F)cc1 | 10.1021/jm801416q | |||
| 44453502 | 311135 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 468 | 4 | 1 | 4 | 4.1 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3cccc(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL402110 | 311135 | 0 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 468 | 4 | 1 | 4 | 4.1 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3cccc(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 10391877 | 181628 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 517 | 9 | 4 | 7 | 2.1 | CC(=O)NCCNC(=O)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391935 | 181628 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 517 | 9 | 4 | 7 | 2.1 | CC(=O)NCCNC(=O)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2 | 10.1016/j.bmcl.2013.04.047 | |||
| 11734303 | 333247 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 547 | 9 | 3 | 3 | 6.5 | CC(C)(C)NC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | |||
| CHEMBL435812 | 333247 | 0 | None | None | None | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 547 | 9 | 3 | 3 | 6.5 | CC(C)(C)NC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | |||
| 10580015 | 25457 | 0 | None | None | None | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 515 | 4 | 1 | 2 | 7.3 | C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1178597 | 25457 | 0 | None | None | None | Mouse | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 515 | 4 | 1 | 2 | 7.3 | C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | |||
| 10000888 | 157636 | 1 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 397 | 6 | 1 | 5 | 4.2 | O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(01)00176-7 | |||
| CHEMBL20539 | 157636 | 1 | None | None | None | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 397 | 6 | 1 | 5 | 4.2 | O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccccc2)CC1 | 10.1016/s0960-894x(01)00176-7 | |||
| 44430732 | 178811 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 514 | 9 | 2 | 7 | 3.4 | CCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL234073 | 178811 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 514 | 9 | 2 | 7 | 3.4 | CCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 25233581 | 350933 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 396 | 4 | 1 | 3 | 3.9 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 | 10.1021/jm801416q | |||
| CHEMBL462441 | 350933 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 396 | 4 | 1 | 3 | 3.9 | CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C#N)cc1 | 10.1021/jm801416q | |||
| 57840522 | 177754 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 504 | 4 | 0 | 5 | 4.6 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C(F)(F)F)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322864 | 177754 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 504 | 4 | 0 | 5 | 4.6 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C(F)(F)F)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 6918497 | 232475 | 1 | None | None | None | Mouse | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL331897 | 232475 | 1 | None | None | None | Mouse | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 527 | 5 | 1 | 2 | 7.6 | CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 | 10.1021/jm0004244 | |||
| 12425 | 11 | 80 | None | None | None | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
| 1318 | 11 | 80 | None | None | None | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
| CHEMBL415879 | 11 | 80 | None | None | None | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
| DB02365 | 11 | 80 | None | None | None | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
| 44309364 | 468890 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 494 | 12 | 3 | 5 | 4.0 | CCNC(=O)C(CCC(C)(C)F)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.022 | |||
| CHEMBL69123 | 468890 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 494 | 12 | 3 | 5 | 4.0 | CCNC(=O)C(CCC(C)(C)F)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1 | 10.1016/j.bmcl.2004.02.022 | |||
| 44430759 | 178023 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 496 | 7 | 2 | 6 | 3.6 | CNc1c(Nc2cc(Cl)ccc2/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL232655 | 178023 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 496 | 7 | 2 | 6 | 3.6 | CNc1c(Nc2cc(Cl)ccc2/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 10623381 | 40784 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 448 | 8 | 2 | 3 | 5.3 | NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | |||
| CHEMBL125111 | 40784 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 448 | 8 | 2 | 3 | 5.3 | NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm0201767 | |||
| 25174463 | 258177 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 422 | 4 | 3 | 4 | 2.5 | CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)CO)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL3679647 | 258177 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 422 | 4 | 3 | 4 | 2.5 | CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)CO)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| 21070984 | 177767 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 478 | 5 | 0 | 5 | 4.7 | Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(Cl)c(OC(C)C)c2)CC1 | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322877 | 177767 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 478 | 5 | 0 | 5 | 4.7 | Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(Cl)c(OC(C)C)c2)CC1 | 10.1016/j.bmcl.2013.01.005 | |||
| 24758044 | 164277 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57888953 | 164277 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| 71455572 | 164277 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2180523 | 164277 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2180528 | 164277 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2180534 | 164277 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 398 | 5 | 1 | 2 | 4.5 | CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| 44430715 | 291267 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 516 | 8 | 2 | 7 | 3.5 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(Cl)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL390706 | 291267 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 516 | 8 | 2 | 7 | 3.5 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(Cl)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 44453402 | 195937 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)cc(Cl)c1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL257698 | 195937 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)cc(Cl)c1 | 10.1016/j.bmcl.2007.09.068 | |||
| 11072063 | 40489 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 597 | 11 | 3 | 4 | 7.2 | COc1ccc(NC(=O)NCC(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm0201767 | |||
| CHEMBL124084 | 40489 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 597 | 11 | 3 | 4 | 7.2 | COc1ccc(NC(=O)NCC(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)(c2ccccc2)c2ccccc2)cc1 | 10.1021/jm0201767 | |||
| 59444266 | 348743 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 477 | 5 | 2 | 4 | 4.4 | CC(C)(CC(=O)N1CCC(O)(c2ncc(Cl)cc2Cl)C(C)(C)C1)NC(=O)c1ccccc1 | nan | |||
| CHEMBL4559773 | 348743 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 477 | 5 | 2 | 4 | 4.4 | CC(C)(CC(=O)N1CCC(O)(c2ncc(Cl)cc2Cl)C(C)(C)C1)NC(=O)c1ccccc1 | nan | |||
| 68818964 | 214055 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 427 | 5 | 2 | 6 | 2.3 | N[C@H](COc1cccc2c1NC(=O)CO2)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | 10.1016/j.bmcl.2013.11.062 | |||
| CHEMBL3099958 | 214055 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 427 | 5 | 2 | 6 | 2.3 | N[C@H](COc1cccc2c1NC(=O)CO2)CN1CCC2(CC1)Cc1cc(F)ccc1O2 | 10.1016/j.bmcl.2013.11.062 | |||
| 12425 | 11 | 80 | None | None | None | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
| 1318 | 11 | 80 | None | None | None | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
| CHEMBL415879 | 11 | 80 | None | None | None | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
| DB02365 | 11 | 80 | None | None | None | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 180 | 0 | 0 | 2 | 2.8 | C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 | 10.1021/jm301121j | |||
| 12112109 | 291923 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 491 | 8 | 3 | 5 | 3.1 | C[C@H]1CN(C(=O)COc2ccc(Cl)cc2NC(=O)NCCN)[C@H](C)CN1Cc1ccc(F)cc1 | 10.1016/j.bmcl.2007.03.037 | |||
| CHEMBL391238 | 291923 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 491 | 8 | 3 | 5 | 3.1 | C[C@H]1CN(C(=O)COc2ccc(Cl)cc2NC(=O)NCCN)[C@H](C)CN1Cc1ccc(F)cc1 | 10.1016/j.bmcl.2007.03.037 | |||
| 57840435 | 177732 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 424 | 5 | 0 | 5 | 4.0 | COc1cc(N2CCN(C(=O)Cn3nc(C(C)C)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322844 | 177732 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 424 | 5 | 0 | 5 | 4.0 | COc1cc(N2CCN(C(=O)Cn3nc(C(C)C)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 58778003 | 177748 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 494 | 4 | 0 | 5 | 4.0 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Br)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322859 | 177748 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 494 | 4 | 0 | 5 | 4.0 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Br)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 24758295 | 164261 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 418 | 6 | 1 | 2 | 5.2 | CC(C)[C@@H](NC(=O)CC1CCCCC1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180505 | 164261 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 418 | 6 | 1 | 2 | 5.2 | CC(C)[C@@H](NC(=O)CC1CCCCC1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 44309312 | 468765 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 460 | 9 | 3 | 5 | 3.4 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCCCC1 | 10.1016/j.bmcl.2004.02.021 | |||
| 44309312 | 468765 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 460 | 9 | 3 | 5 | 3.4 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCCCC1 | 10.1016/j.bmcl.2004.02.022 | |||
| 44309337 | 468765 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 460 | 9 | 3 | 5 | 3.4 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCCCC1 | 10.1016/j.bmcl.2004.02.021 | |||
| 44309337 | 468765 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 460 | 9 | 3 | 5 | 3.4 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCCCC1 | 10.1016/j.bmcl.2004.02.022 | |||
| CHEMBL68145 | 468765 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 460 | 9 | 3 | 5 | 3.4 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCCCC1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL68145 | 468765 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 460 | 9 | 3 | 5 | 3.4 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCCCC1 | 10.1016/j.bmcl.2004.02.022 | |||
| CHEMBL69375 | 468765 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 460 | 9 | 3 | 5 | 3.4 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCCCC1 | 10.1016/j.bmcl.2004.02.021 | |||
| CHEMBL69375 | 468765 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 460 | 9 | 3 | 5 | 3.4 | NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCCCC1 | 10.1016/j.bmcl.2004.02.022 | |||
| 71680936 | 181991 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 563 | 8 | 3 | 6 | 3.2 | CC(C)[C@@H](NC(=O)C1CCCC1(O)CCN1CCOCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398750 | 181991 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 563 | 8 | 3 | 6 | 3.2 | CC(C)[C@@H](NC(=O)C1CCCC1(O)CCN1CCOCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 10254761 | 181596 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 484 | 6 | 2 | 6 | 2.6 | Cc1ccc(C(=O)N2CC[C@H](O)C2)c(OC[C@@H](O)CN2CCC3(CC2)Cc2cc(F)ccc2O3)c1 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391798 | 181596 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 484 | 6 | 2 | 6 | 2.6 | Cc1ccc(C(=O)N2CC[C@H](O)C2)c(OC[C@@H](O)CN2CCC3(CC2)Cc2cc(F)ccc2O3)c1 | 10.1016/j.bmcl.2013.04.047 | |||
| 57889649 | 181974 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 486 | 6 | 3 | 4 | 3.9 | CC(C)[C@@H](NC(=O)c1cccc(C(=O)O)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398733 | 181974 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 486 | 6 | 3 | 4 | 3.9 | CC(C)[C@@H](NC(=O)c1cccc(C(=O)O)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 24759420 | 164269 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 448 | 5 | 1 | 2 | 5.7 | CC(C)C(NC(=O)c1ccc2ccccc2c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180513 | 164269 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 448 | 5 | 1 | 2 | 5.7 | CC(C)C(NC(=O)c1ccc2ccccc2c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 44453403 | 195510 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1c(Cl)cccc1Cl | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL255629 | 195510 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 4.3 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1c(Cl)cccc1Cl | 10.1016/j.bmcl.2007.09.068 | |||
| 44430736 | 309585 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 576 | 10 | 2 | 7 | 4.5 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2ccccc2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL397956 | 309585 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 576 | 10 | 2 | 7 | 4.5 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2ccccc2)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 44453263 | 311580 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 442 | 7 | 2 | 4 | 3.6 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL404732 | 311580 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 442 | 7 | 2 | 4 | 3.6 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2007.09.068 | |||
| 10695296 | 200030 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 460 | 4 | 1 | 3 | 6.6 | O=C(NC1CCN(CC2CCCCCCCCC2)CC1)C1c2ccccc2Oc2ccccc21 | 10.1016/j.ejmech.2020.113085 | |||
| CHEMBL285703 | 200030 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 460 | 4 | 1 | 3 | 6.6 | O=C(NC1CCN(CC2CCCCCCCCC2)CC1)C1c2ccccc2Oc2ccccc21 | 10.1016/j.ejmech.2020.113085 | |||
| 10816699 | 25456 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 433 | 6 | 1 | 1 | 5.9 | C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1178593 | 25456 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 433 | 6 | 1 | 1 | 5.9 | C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm0004244 | |||
| 10695296 | 200030 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 460 | 4 | 1 | 3 | 6.6 | O=C(NC1CCN(CC2CCCCCCCCC2)CC1)C1c2ccccc2Oc2ccccc21 | 10.1021/jm0004244 | |||
| CHEMBL285703 | 200030 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 460 | 4 | 1 | 3 | 6.6 | O=C(NC1CCN(CC2CCCCCCCCC2)CC1)C1c2ccccc2Oc2ccccc21 | 10.1021/jm0004244 | |||
| 44309091 | 468731 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 439 | 10 | 3 | 4 | 4.2 | CC(C)C[C@H](C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1)C(N)=O | 10.1016/j.bmcl.2004.02.020 | |||
| CHEMBL67809 | 468731 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 439 | 10 | 3 | 4 | 4.2 | CC(C)C[C@H](C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1)C(N)=O | 10.1016/j.bmcl.2004.02.020 | |||
| 59444207 | 336368 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 470 | 7 | 2 | 3 | 4.4 | CC(C)[C@@H](CNC(=O)Cc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | nan | |||
| CHEMBL4468705 | 336368 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 470 | 7 | 2 | 3 | 4.4 | CC(C)[C@@H](CNC(=O)Cc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | nan | |||
| 49865901 | 40076 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 463 | 4 | 1 | 4 | 5.7 | Cc1nc([C@H]2CCCN2C(=O)Nc2ccc(C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)n1 | 10.1016/j.bmcl.2010.07.082 | |||
| CHEMBL1224121 | 40076 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 463 | 4 | 1 | 4 | 5.7 | Cc1nc([C@H]2CCCN2C(=O)Nc2ccc(C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)n1 | 10.1016/j.bmcl.2010.07.082 | |||
| 59474969 | 258187 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 482 | 4 | 2 | 3 | 5.2 | CC1(C)CN(C(=O)[C@H]2CCCC[C@@]2(C)NC(=O)c2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL3679658 | 258187 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 482 | 4 | 2 | 3 | 5.2 | CC1(C)CN(C(=O)[C@H]2CCCC[C@@]2(C)NC(=O)c2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| 24758745 | 164254 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 412 | 7 | 1 | 2 | 4.6 | CC[C@@H](NC(=O)CCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180498 | 164254 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 412 | 7 | 1 | 2 | 4.6 | CC[C@@H](NC(=O)CCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 44309245 | 468458 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 556 | 13 | 3 | 5 | 5.2 | CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NCc1ccccc1 | 10.1016/j.bmcl.2004.02.022 | |||
| CHEMBL65784 | 468458 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 556 | 13 | 3 | 5 | 5.2 | CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NCc1ccccc1 | 10.1016/j.bmcl.2004.02.022 | |||
| 57888886 | 164282 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.1 | CC(C)C(NC(=O)OCc1ccccc1)C(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180529 | 164282 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 444 | 6 | 2 | 4 | 4.1 | CC(C)C(NC(=O)OCc1ccccc1)C(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 25174628 | 258178 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 498 | 5 | 3 | 4 | 4.2 | CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)[C@H](O)c2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| 25174629 | 258178 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 498 | 5 | 3 | 4 | 4.2 | CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)[C@H](O)c2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL3679648 | 258178 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 498 | 5 | 3 | 4 | 4.2 | CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)[C@H](O)c2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL3679649 | 258178 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 498 | 5 | 3 | 4 | 4.2 | CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)[C@H](O)c2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| 9999626 | 178927 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 376 | 5 | 0 | 3 | 3.6 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1 | 10.1016/j.bmcl.2007.03.037 | |||
| CHEMBL234622 | 178927 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 376 | 5 | 0 | 3 | 3.6 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1 | 10.1016/j.bmcl.2007.03.037 | |||
| 57889944 | 164294 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 426 | 6 | 1 | 2 | 5.2 | Cc1ccccc1C(=O)NC(CC(C)C)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180543 | 164294 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 426 | 6 | 1 | 2 | 5.2 | Cc1ccccc1C(=O)NC(CC(C)C)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 68963698 | 181605 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 543 | 7 | 3 | 7 | 2.6 | CC(=O)N[C@H]1CCN(C(=O)c2ccc(O)cc2OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)C1 | 10.1016/j.bmcl.2013.04.047 | |||
| CHEMBL2391807 | 181605 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 543 | 7 | 3 | 7 | 2.6 | CC(=O)N[C@H]1CCN(C(=O)c2ccc(O)cc2OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)C1 | 10.1016/j.bmcl.2013.04.047 | |||
| 44453467 | 196094 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 502 | 4 | 1 | 4 | 4.8 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL258359 | 196094 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 502 | 4 | 1 | 4 | 4.8 | O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)c(Cl)c3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 10985078 | 233741 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 635 | 10 | 3 | 3 | 8.2 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccc(C(F)(F)F)cc1 | 10.1021/jm0201767 | |||
| CHEMBL333865 | 233741 | 0 | None | None | None | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 635 | 10 | 3 | 3 | 8.2 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccc(C(F)(F)F)cc1 | 10.1021/jm0201767 | |||
| 57889635 | 233486 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 4 | 2 | 3 | 3.6 | CC(C)[C@@H](NC(=O)N1CCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| CHEMBL3334819 | 233486 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 435 | 4 | 2 | 3 | 3.6 | CC(C)[C@@H](NC(=O)N1CCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1021/jm5003167 | |||
| 68818375 | 178229 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 443 | 7 | 2 | 6 | 3.0 | COc1ccc(NC(C)=O)c(OC[C@@H](N)CN2CCC3(CC2)Cc2cc(F)ccc2O3)c1 | 10.1016/j.bmcl.2012.12.095 | |||
| CHEMBL2332938 | 178229 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 443 | 7 | 2 | 6 | 3.0 | COc1ccc(NC(C)=O)c(OC[C@@H](N)CN2CCC3(CC2)Cc2cc(F)ccc2O3)c1 | 10.1016/j.bmcl.2012.12.095 | |||
| 44309397 | 468791 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 466 | 11 | 3 | 5 | 3.4 | CC(C)(F)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O | 10.1016/j.bmcl.2004.02.022 | |||
| CHEMBL68366 | 468791 | 0 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 466 | 11 | 3 | 5 | 3.4 | CC(C)(F)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O | 10.1016/j.bmcl.2004.02.022 | |||
| 52916803 | 335526 | 28 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 451 | 5 | 1 | 7 | 2.8 | CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 | 10.6019/CHEMBL4507278 | |||
| CHEMBL4456123 | 335526 | 28 | None | None | None | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 451 | 5 | 1 | 7 | 2.8 | CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 | 10.6019/CHEMBL4507278 | |||
| 44537841 | 1390 | 22 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 57889181 | 1390 | 22 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 9497 | 1390 | 22 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL2398716 | 1390 | 22 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| CHEMBL3334824 | 1390 | 22 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 10.1021/jm5003167 | |||
| 57888707 | 182006 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 413 | 6 | 1 | 3 | 3.8 | CC(C)[C@@H](NC(=O)Cc1ccncc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398768 | 182006 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 413 | 6 | 1 | 3 | 3.8 | CC(C)[C@@H](NC(=O)Cc1ccncc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.04.079 | |||
| 10555551 | 25450 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 473 | 6 | 1 | 2 | 6.6 | C=CC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| CHEMBL1178575 | 25450 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 473 | 6 | 1 | 2 | 6.6 | C=CC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1 | 10.1021/jm0004244 | |||
| 57888900 | 182005 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 521 | 6 | 3 | 5 | 2.9 | CC(C)[C@@H](NC(=O)c1cccc(S(N)(=O)=O)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398767 | 182005 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 521 | 6 | 3 | 5 | 2.9 | CC(C)[C@@H](NC(=O)c1cccc(S(N)(=O)=O)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 57888966 | 182009 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 476 | 5 | 2 | 3 | 4.9 | CC(C)[C@@H](NC(=O)c1cccc(Cl)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| CHEMBL2398771 | 182009 | 0 | None | None | None | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 476 | 5 | 2 | 3 | 4.9 | CC(C)[C@@H](NC(=O)c1cccc(Cl)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | 10.1016/j.bmcl.2013.04.079 | |||
| 44430725 | 332532 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 480 | 8 | 2 | 7 | 2.6 | CNc1c(Nc2cc(C)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL430356 | 332532 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 480 | 8 | 2 | 7 | 2.6 | CNc1c(Nc2cc(C)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 25022507 | 311387 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 512 | 4 | 1 | 4 | 4.2 | O=S(=O)(c1ccccc1Br)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL403728 | 311387 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 512 | 4 | 1 | 4 | 4.2 | O=S(=O)(c1ccccc1Br)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 44453361 | 332112 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 456 | 7 | 2 | 4 | 4.0 | Cc1cccc(Cl)c1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL429419 | 332112 | 0 | None | None | None | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 456 | 7 | 2 | 4 | 4.0 | Cc1cccc(Cl)c1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 21070989 | 177765 | 0 | None | None | None | Mouse | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322875 | 177765 | 0 | None | None | None | Mouse | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 450 | 4 | 0 | 5 | 3.9 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 44453165 | 196097 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 492 | 8 | 2 | 5 | 3.9 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(OC(F)(F)F)cc1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL258362 | 196097 | 0 | None | None | None | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 492 | 8 | 2 | 5 | 3.9 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(OC(F)(F)F)cc1 | 10.1016/j.bmcl.2007.09.068 | |||
| 44453229 | 195770 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 426 | 7 | 2 | 4 | 3.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL256889 | 195770 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 426 | 7 | 2 | 4 | 3.1 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1016/j.bmcl.2007.09.068 | |||
| 57840460 | 177744 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 464 | 4 | 0 | 5 | 4.3 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)C[C@H]2C)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322855 | 177744 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 464 | 4 | 0 | 5 | 4.3 | COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)C[C@H]2C)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 44430722 | 177716 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 466 | 8 | 2 | 7 | 2.3 | CNc1c(Nc2ccccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL232252 | 177716 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 466 | 8 | 2 | 7 | 2.3 | CNc1c(Nc2ccccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 1370410 | 177778 | 10 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 404 | 3 | 0 | 4 | 3.4 | Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322888 | 177778 | 10 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 404 | 3 | 0 | 4 | 3.4 | Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(F)cc2)CC1 | 10.1016/j.bmcl.2013.01.005 | |||
| 25174306 | 258175 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 503 | 6 | 2 | 4 | 4.3 | CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)CCN2CCCCC2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| CHEMBL3679645 | 258175 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 503 | 6 | 2 | 4 | 4.3 | CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)CCN2CCCCC2)CC[C@]1(O)c1ccc(Cl)cc1 | nan | |||
| 57889234 | 164283 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 398 | 5 | 2 | 3 | 3.1 | CC(C)C(NC(=O)c1ccccc1)C(=O)N1CCC(O)(c2ccc(F)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180530 | 164283 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 398 | 5 | 2 | 3 | 3.1 | CC(C)C(NC(=O)c1ccccc1)C(=O)N1CCC(O)(c2ccc(F)cc2)CC1 | 10.1021/jm300896d | |||
| 44453167 | 196098 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 4.0 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL258363 | 196098 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 476 | 7 | 2 | 4 | 4.0 | O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(C(F)(F)F)cc1 | 10.1016/j.bmcl.2007.09.068 | |||
| 57991690 | 164270 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 8 | 1 | 2 | 5.2 | CC(C)[C@@H](NC(=O)CCCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| CHEMBL2180516 | 164270 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 440 | 8 | 1 | 2 | 5.2 | CC(C)[C@@H](NC(=O)CCCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 | 10.1021/jm300896d | |||
| 44430746 | 177992 | 0 | None | None | None | Mouse | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 530 | 10 | 3 | 8 | 2.3 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL232638 | 177992 | 0 | None | None | None | Mouse | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 530 | 10 | 3 | 8 | 2.3 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 44430748 | 178095 | 0 | None | None | None | Mouse | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 529 | 10 | 3 | 8 | 2.3 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL232837 | 178095 | 0 | None | None | None | Mouse | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 529 | 10 | 3 | 8 | 2.3 | C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 57840315 | 177737 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 412 | 5 | 1 | 6 | 2.3 | COc1cc(N2CCN(C(=O)Cn3nc(CO)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322849 | 177737 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 412 | 5 | 1 | 6 | 2.3 | COc1cc(N2CCN(C(=O)Cn3nc(CO)c(Cl)c3C)CC2)ccc1Cl | 10.1016/j.bmcl.2013.01.005 | |||
| 44430717 | 177636 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 518 | 8 | 2 | 7 | 3.1 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)c(F)c3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| CHEMBL232043 | 177636 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 518 | 8 | 2 | 7 | 3.1 | CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)c(F)c3)C[C@H]2C)c(=O)c1=O | 10.1016/j.bmcl.2007.03.104 | |||
| 44453225 | 196100 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 440 | 4 | 1 | 5 | 3.5 | O=S(=O)(c1cccs1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| CHEMBL258368 | 196100 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | 440 | 4 | 1 | 5 | 3.5 | O=S(=O)(c1cccs1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 | 10.1016/j.bmcl.2007.09.068 | |||
| 21071094 | 177780 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 420 | 3 | 0 | 4 | 3.9 | Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2322890 | 177780 | 0 | None | None | None | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 420 | 3 | 0 | 4 | 3.9 | Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(Cl)cc2)CC1 | 10.1016/j.bmcl.2013.01.005 | |||
| 21071099 | 177824 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 454 | 3 | 0 | 4 | 4.2 | Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(C(F)(F)F)cc2)CC1 | 10.1016/j.bmcl.2013.01.005 | |||
| CHEMBL2323419 | 177824 | 0 | None | None | None | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 454 | 3 | 0 | 4 | 4.2 | Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(C(F)(F)F)cc2)CC1 | 10.1016/j.bmcl.2013.01.005 | |||
| 59444200 | 347298 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 514 | 7 | 2 | 5 | 4.6 | CCOC(=O)c1cc(C2(O)CCN(C(=O)CC(C)(C)NC(=O)c3ccccc3)CC2(C)C)ccc1Cl | nan | |||
| CHEMBL4522473 | 347298 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 514 | 7 | 2 | 5 | 4.6 | CCOC(=O)c1cc(C2(O)CCN(C(=O)CC(C)(C)NC(=O)c3ccccc3)CC2(C)C)ccc1Cl | nan | |||
| 25176401 | 258173 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 422 | 3 | 2 | 4 | 3.7 | COC(=O)N[C@@H]1CCCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | nan | |||
| CHEMBL3679643 | 258173 | 0 | None | None | None | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 422 | 3 | 2 | 4 | 3.7 | COC(=O)N[C@@H]1CCCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | nan | |||
| 512282 | 1562 | 44 | None | 199 | 2 | Human | 9.0 | pKd | = | 9 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1021/jm300682j | |||
| 767 | 1562 | 44 | None | 199 | 2 | Human | 9.0 | pKd | = | 9 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1021/jm300682j | |||
| CHEMBL232656 | 1562 | 44 | None | 199 | 2 | Human | 9.0 | pKd | = | 9 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1021/jm300682j | |||
| 512282 | 1562 | 44 | None | -199 | 2 | Mouse | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1021/jm300682j | |||
| 767 | 1562 | 44 | None | -199 | 2 | Mouse | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1021/jm300682j | |||
| CHEMBL232656 | 1562 | 44 | None | -199 | 2 | Mouse | 6.7 | pKd | = | 6.7 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1021/jm300682j | |||
| 25109291 | 366002 | 9 | None | 56 | 12 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 327 | 1 | 2 | 6 | 1.7 | Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 | 10.1021/jm8007618 | |||
| CHEMBL519240 | 366002 | 9 | None | 56 | 12 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 327 | 1 | 2 | 6 | 1.7 | Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 | 10.1021/jm8007618 | |||
| 57889392 | 255028 | 0 | None | None | None | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 423 | 5 | 3 | 3 | 3.5 | CC(C)NC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | nan | |||
| CHEMBL3656279 | 255028 | 0 | None | None | None | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 423 | 5 | 3 | 3 | 3.5 | CC(C)NC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | nan | |||
| 57889423 | 181988 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 434 | 5 | 2 | 3 | 4.1 | CC(C)[C@@H](NC(=O)C1CCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | nan | |||
| CHEMBL2398747 | 181988 | 0 | None | None | None | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 434 | 5 | 2 | 3 | 4.1 | CC(C)[C@@H](NC(=O)C1CCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1 | nan | |||
| 512282 | 1562 | 44 | None | None | None | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1021/jm300682j | |||
| 767 | 1562 | 44 | None | None | None | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1021/jm300682j | |||
| CHEMBL232656 | 1562 | 44 | None | None | None | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10.1021/jm300682j | |||
| 10371087 | 155195 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 584 | 6 | 2 | 5 | 6.0 | NCC1CCCN(C(=O)c2ccc3c(c2)C(C(=O)NC2CCN(C/C4=C/CCCCCCC4)CC2)c2ccccc2O3)C1 | 10.1021/jm300682j | |||
| CHEMBL2178571 | 155195 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 584 | 6 | 2 | 5 | 6.0 | NCC1CCCN(C(=O)c2ccc3c(c2)C(C(=O)NC2CCN(C/C4=C/CCCCCCC4)CC2)c2ccccc2O3)C1 | 10.1021/jm300682j | |||
| 10111333 | 349467 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 395 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4577133 | 349467 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 395 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 71461438 | 174964 | 0 | None | -100 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 416 | 5 | 1 | 5 | 4.1 | O=S(=O)(Nc1cc(Cl)ccc1Cn1cnnc1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207082 | 174964 | 0 | None | -100 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 416 | 5 | 1 | 5 | 4.1 | O=S(=O)(Nc1cc(Cl)ccc1Cn1cnnc1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 71214725 | 174965 | 0 | None | -25 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 416 | 5 | 1 | 5 | 4.1 | O=S(=O)(Nc1cc(Cl)ccc1Cn1cncn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207083 | 174965 | 0 | None | -25 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 416 | 5 | 1 | 5 | 4.1 | O=S(=O)(Nc1cc(Cl)ccc1Cn1cncn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 71461439 | 174969 | 0 | None | -10 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 3.4 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207087 | 174969 | 0 | None | -10 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 3.4 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)cc1 | 10.1016/j.bmcl.2012.09.020 | |||
| 71452488 | 174975 | 0 | None | -19 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 388 | 5 | 1 | 6 | 3.5 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)s1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207093 | 174975 | 0 | None | -19 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 388 | 5 | 1 | 6 | 3.5 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)s1 | 10.1016/j.bmcl.2012.09.020 | |||
| 71461440 | 174979 | 0 | None | -31 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 400 | 5 | 1 | 5 | 3.6 | O=S(=O)(Nc1cc(F)ccc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207097 | 174979 | 0 | None | -31 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 400 | 5 | 1 | 5 | 3.6 | O=S(=O)(Nc1cc(F)ccc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 15604497 | 174981 | 0 | None | -39 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 432 | 5 | 1 | 7 | 3.0 | Cn1nnnc1Cc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207099 | 174981 | 0 | None | -39 | 3 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 432 | 5 | 1 | 7 | 3.0 | Cn1nnnc1Cc1ncc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 10809142 | 78844 | 0 | None | None | None | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 4.1 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccnc1 | 10.1021/jm990316l | |||
| CHEMBL143741 | 78844 | 0 | None | None | None | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 4.1 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccnc1 | 10.1021/jm990316l | |||
| 68557448 | 334779 | 0 | None | None | None | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 417 | 5 | 1 | 5 | 4.2 | COc1cccc(N2CCC(C(O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)c1 | nan | |||
| CHEMBL4445508 | 334779 | 0 | None | None | None | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 417 | 5 | 1 | 5 | 4.2 | COc1cccc(N2CCC(C(O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)c1 | nan | |||
| 10788075 | 238171 | 0 | None | None | None | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 416 | 7 | 1 | 4 | 5.3 | N#CC(CCCN1CCC(O)(c2cccs2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL344751 | 238171 | 0 | None | None | None | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 416 | 7 | 1 | 4 | 5.3 | N#CC(CCCN1CCC(O)(c2cccs2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| 10111333 | 349467 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 395 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4577133 | 349467 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 395 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 155568814 | 350038 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 403 | 5 | 1 | 5 | 3.8 | COc1cc(N2CCC(C(O)Cn3ccc(C(F)(F)F)n3)CC2)ccc1Cl | nan | |||
| CHEMBL4590794 | 350038 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 403 | 5 | 1 | 5 | 3.8 | COc1cc(N2CCC(C(O)Cn3ccc(C(F)(F)F)n3)CC2)ccc1Cl | nan | |||
| 10599794 | 77706 | 0 | None | None | None | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 453 | 8 | 1 | 4 | 5.3 | CN(C)c1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1021/jm990316l | |||
| CHEMBL142628 | 77706 | 0 | None | None | None | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 453 | 8 | 1 | 4 | 5.3 | CN(C)c1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1021/jm990316l | |||
| 10526132 | 144690 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 419 | 7 | 1 | 2 | 6.2 | OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm990316l | |||
| CHEMBL198935 | 144690 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 419 | 7 | 1 | 2 | 6.2 | OC1(c2ccc(Cl)cc2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm990316l | |||
| 44362079 | 237946 | 0 | None | None | None | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 422 | 5 | 1 | 3 | 5.2 | N#CC1(CCCN2CCC(O)(c3ccccc3)CC2)c2ccccc2Cc2ccccc21 | 10.1021/jm990316l | |||
| CHEMBL343032 | 237946 | 0 | None | None | None | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 422 | 5 | 1 | 3 | 5.2 | N#CC1(CCCN2CCC(O)(c3ccccc3)CC2)c2ccccc2Cc2ccccc21 | 10.1021/jm990316l | |||
| 24863547 | 348754 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 484 | 5 | 1 | 5 | 5.4 | COc1cc(N2CCC(C(N)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)c(Cl)cc1Cl | nan | |||
| CHEMBL4559982 | 348754 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 484 | 5 | 1 | 5 | 5.4 | COc1cc(N2CCC(C(N)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)c(Cl)cc1Cl | nan | |||
| 10811393 | 78377 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 407 | 7 | 1 | 4 | 4.8 | N#CCC(C#N)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL143194 | 78377 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 407 | 7 | 1 | 4 | 4.8 | N#CCC(C#N)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/jm990316l | |||
| 24863719 | 349849 | 0 | None | None | None | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 465 | 5 | 1 | 5 | 5.2 | COc1cc(N2CCC(C)(C(O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | nan | |||
| CHEMBL4586066 | 349849 | 0 | None | None | None | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 465 | 5 | 1 | 5 | 5.2 | COc1cc(N2CCC(C)(C(O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl | nan | |||
| 71214976 | 174984 | 0 | None | -100 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 450 | 5 | 1 | 5 | 4.5 | O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207101 | 174984 | 0 | None | -100 | 3 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 450 | 5 | 1 | 5 | 4.5 | O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 10547456 | 238325 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 374 | 6 | 1 | 4 | 4.8 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccs1 | 10.1021/jm990316l | |||
| CHEMBL346205 | 238325 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 374 | 6 | 1 | 4 | 4.8 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccs1 | 10.1021/jm990316l | |||
| 10503785 | 239731 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 451 | 7 | 1 | 4 | 5.3 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)N1CCCCC1 | 10.1021/jm990316l | |||
| CHEMBL357434 | 239731 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 451 | 7 | 1 | 4 | 5.3 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)N1CCCCC1 | 10.1021/jm990316l | |||
| 10528677 | 333206 | 0 | None | None | None | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 478 | 7 | 1 | 3 | 6.6 | N#CC(CCCN1CCC(O)(c2cc(Cl)cc(Cl)c2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL435480 | 333206 | 0 | None | None | None | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 478 | 7 | 1 | 3 | 6.6 | N#CC(CCCN1CCC(O)(c2cc(Cl)cc(Cl)c2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| 10812461 | 160350 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 428 | 7 | 1 | 3 | 5.4 | N#CC(CCCN1CCC(O)(c2ccc(F)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL2112832 | 160350 | 0 | None | None | None | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 428 | 7 | 1 | 3 | 5.4 | N#CC(CCCN1CCC(O)(c2ccc(F)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| 10133557 | 337057 | 0 | None | -1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 367 | 3 | 1 | 3 | 4.4 | CC(=O)C1=C(O)C(=O)N(c2ccc(C(F)(F)F)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4483771 | 337057 | 0 | None | -1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 367 | 3 | 1 | 3 | 4.4 | CC(=O)C1=C(O)C(=O)N(c2ccc(C(F)(F)F)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 10645391 | 67200 | 0 | None | None | None | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 412 | 8 | 1 | 4 | 5.1 | CCOc1ccc(C(C#N)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1 | 10.1021/jm990316l | |||
| CHEMBL142107 | 67200 | 0 | None | None | None | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 412 | 8 | 1 | 4 | 5.1 | CCOc1ccc(C(C#N)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1 | 10.1021/jm990316l | |||
| 10133557 | 337057 | 0 | None | -1 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 367 | 3 | 1 | 3 | 4.4 | CC(=O)C1=C(O)C(=O)N(c2ccc(C(F)(F)F)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4483771 | 337057 | 0 | None | -1 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 367 | 3 | 1 | 3 | 4.4 | CC(=O)C1=C(O)C(=O)N(c2ccc(C(F)(F)F)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 68552829 | 335851 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 473 | 7 | 2 | 6 | 3.2 | COc1cc(N2CCC(C(Cn3nc(C(F)(F)F)cc3C)NC(=O)CN)CC2)ccc1Cl | nan | |||
| CHEMBL4461035 | 335851 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 473 | 7 | 2 | 6 | 3.2 | COc1cc(N2CCC(C(Cn3nc(C(F)(F)F)cc3C)NC(=O)CN)CC2)ccc1Cl | nan | |||
| 12093167 | 327835 | 32 | None | -1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.4c02102 | |||
| CHEMBL4475389 | 327835 | 32 | None | -1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.4c02102 | |||
| 12093167 | 327835 | 32 | None | -1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4475389 | 327835 | 32 | None | -1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 12093167 | 327835 | 32 | None | -1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.4c02102 | |||
| CHEMBL4475389 | 327835 | 32 | None | -1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.4c02102 | |||
| 12093167 | 327835 | 32 | None | -1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4475389 | 327835 | 32 | None | -1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 351 | 3 | 1 | 3 | 4.2 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 10743274 | 238079 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 478 | 7 | 1 | 3 | 6.3 | N#CC(CCCN1CCC(O)(c2ccc(C(F)(F)F)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL344075 | 238079 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 478 | 7 | 1 | 3 | 6.3 | N#CC(CCCN1CCC(O)(c2ccc(C(F)(F)F)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| 68551780 | 348208 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 418 | 5 | 1 | 6 | 3.5 | COc1cc(N2CCC(C(O)Cn3nc(C(F)(F)F)nc3C)CC2)ccc1Cl | nan | |||
| CHEMBL4546480 | 348208 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 418 | 5 | 1 | 6 | 3.5 | COc1cc(N2CCC(C(O)Cn3nc(C(F)(F)F)nc3C)CC2)ccc1Cl | nan | |||
| 10833944 | 237552 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 384 | 6 | 2 | 4 | 4.4 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(O)c1 | 10.1021/jm990316l | |||
| CHEMBL341840 | 237552 | 0 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 384 | 6 | 2 | 4 | 4.4 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(O)c1 | 10.1021/jm990316l | |||
| 71214710 | 174967 | 0 | None | -100 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 431 | 5 | 1 | 6 | 3.6 | Cn1nnnc1Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207085 | 174967 | 0 | None | -100 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 431 | 5 | 1 | 6 | 3.6 | Cn1nnnc1Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 71452487 | 174970 | 0 | None | -15 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 3.4 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cccc(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207088 | 174970 | 0 | None | -15 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 382 | 5 | 1 | 5 | 3.4 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cccc(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 71454247 | 174972 | 0 | None | -15 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 366 | 5 | 1 | 5 | 2.9 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cccc(F)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207090 | 174972 | 0 | None | -15 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 366 | 5 | 1 | 5 | 2.9 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cccc(F)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 71456008 | 174977 | 0 | None | -25 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 404 | 5 | 1 | 6 | 4.0 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1csc2ccccc12 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207095 | 174977 | 0 | None | -25 | 3 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 404 | 5 | 1 | 6 | 4.0 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1csc2ccccc12 | 10.1016/j.bmcl.2012.09.020 | |||
| 3798520 | 334998 | 7 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 307 | 3 | 1 | 3 | 3.5 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1ccccc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4448679 | 334998 | 7 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 307 | 3 | 1 | 3 | 3.5 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1ccccc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 3798520 | 334998 | 7 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 307 | 3 | 1 | 3 | 3.5 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1ccccc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4448679 | 334998 | 7 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 307 | 3 | 1 | 3 | 3.5 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1ccccc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 3063068 | 66875 | 1 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 468 | 5 | 1 | 4 | 6.2 | Cc1ccccc1C1(O)CCN(CCCC2(C#N)c3ccccc3CSc3ccccc32)CC1 | 10.1021/jm990316l | |||
| CHEMBL141829 | 66875 | 1 | None | None | None | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 468 | 5 | 1 | 4 | 6.2 | Cc1ccccc1C1(O)CCN(CCCC2(C#N)c3ccccc3CSc3ccccc32)CC1 | 10.1021/jm990316l | |||
| 9967166 | 334536 | 7 | None | -2 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 327 | 4 | 1 | 3 | 3.9 | CCc1ccc(N2C(=O)C(O)=C(C(C)=O)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4441958 | 334536 | 7 | None | -2 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 327 | 4 | 1 | 3 | 3.9 | CCc1ccc(N2C(=O)C(O)=C(C(C)=O)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 9967166 | 334536 | 7 | None | -2 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 327 | 4 | 1 | 3 | 3.9 | CCc1ccc(N2C(=O)C(O)=C(C(C)=O)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4441958 | 334536 | 7 | None | -2 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 327 | 4 | 1 | 3 | 3.9 | CCc1ccc(N2C(=O)C(O)=C(C(C)=O)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 155535265 | 336546 | 0 | None | 8 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 339 | 4 | 1 | 3 | 4.1 | Cc1ccc(N2C(=O)C(O)=C(C(=O)C3CC3)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4471583 | 336546 | 0 | None | 8 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 339 | 4 | 1 | 3 | 4.1 | Cc1ccc(N2C(=O)C(O)=C(C(=O)C3CC3)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 155532102 | 336259 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 385 | 3 | 1 | 3 | 4.2 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1cccc(Br)c1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4467095 | 336259 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 385 | 3 | 1 | 3 | 4.2 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1cccc(Br)c1 | 10.1021/acs.jmedchem.8b00605 | |||
| 155532102 | 336259 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 385 | 3 | 1 | 3 | 4.2 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1cccc(Br)c1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4467095 | 336259 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 385 | 3 | 1 | 3 | 4.2 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1cccc(Br)c1 | 10.1021/acs.jmedchem.8b00605 | |||
| 155535265 | 336546 | 0 | None | 8 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 339 | 4 | 1 | 3 | 4.1 | Cc1ccc(N2C(=O)C(O)=C(C(=O)C3CC3)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4471583 | 336546 | 0 | None | 8 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 339 | 4 | 1 | 3 | 4.1 | Cc1ccc(N2C(=O)C(O)=C(C(=O)C3CC3)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 155561022 | 349004 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 321 | 3 | 1 | 3 | 3.8 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1ccc(C)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4566226 | 349004 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 321 | 3 | 1 | 3 | 3.8 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1ccc(C)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 155553428 | 348249 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 4.1 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1cccc(Cl)c1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4547735 | 348249 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 4.1 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1cccc(Cl)c1 | 10.1021/acs.jmedchem.8b00605 | |||
| 155561022 | 349004 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 321 | 3 | 1 | 3 | 3.8 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1ccc(C)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4566226 | 349004 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 321 | 3 | 1 | 3 | 3.8 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1ccc(C)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 54712652 | 334545 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 343 | 4 | 1 | 4 | 3.7 | CCOC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4442093 | 334545 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 343 | 4 | 1 | 4 | 3.7 | CCOC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 155553428 | 348249 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 4.1 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1cccc(Cl)c1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4547735 | 348249 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 4.1 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1cccc(Cl)c1 | 10.1021/acs.jmedchem.8b00605 | |||
| 71463166 | 174978 | 0 | None | -7 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 390 | 5 | 1 | 8 | 2.3 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cccc2nonc12 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207096 | 174978 | 0 | None | -7 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 390 | 5 | 1 | 8 | 2.3 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cccc2nonc12 | 10.1016/j.bmcl.2012.09.020 | |||
| 57889188 | 233483 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 437 | 6 | 3 | 3 | 3.9 | CC[C@@H](C)NC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | nan | |||
| CHEMBL3334816 | 233483 | 0 | None | None | None | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 437 | 6 | 3 | 3 | 3.9 | CC[C@@H](C)NC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | nan | |||
| 71462570 | 163992 | 0 | None | -2 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 518 | 5 | 2 | 5 | 5.6 | CC1(C)CN(CC/C=C2/c3cc(C(=O)O)ccc3OCc3ncccc32)C[C@H](c2ccc(Cl)cc2)[C@H]1O | 10.1021/jm300682j | |||
| CHEMBL2178569 | 163992 | 0 | None | -2 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 518 | 5 | 2 | 5 | 5.6 | CC1(C)CN(CC/C=C2/c3cc(C(=O)O)ccc3OCc3ncccc32)C[C@H](c2ccc(Cl)cc2)[C@H]1O | 10.1021/jm300682j | |||
| 57889334 | 181984 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 422 | 6 | 2 | 3 | 4.0 | CC(C)CC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | nan | |||
| CHEMBL2398743 | 181984 | 0 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 422 | 6 | 2 | 3 | 4.0 | CC(C)CC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C | nan | |||
| 54712652 | 334545 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 343 | 4 | 1 | 4 | 3.7 | CCOC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4442093 | 334545 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 343 | 4 | 1 | 4 | 3.7 | CCOC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 3063066 | 67365 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 454 | 5 | 1 | 4 | 5.9 | N#CC1(CCCN2CCC(O)(c3ccccc3)CC2)c2ccccc2CSc2ccccc21 | 10.1021/jm990316l | |||
| CHEMBL142244 | 67365 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 454 | 5 | 1 | 4 | 5.9 | N#CC1(CCCN2CCC(O)(c3ccccc3)CC2)c2ccccc2CSc2ccccc21 | 10.1021/jm990316l | |||
| 10695080 | 26473 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 418 | 6 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 | 10.1021/jm990316l | |||
| CHEMBL1184276 | 26473 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 418 | 6 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 | 10.1021/jm990316l | |||
| 10645313 | 65924 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 411 | 7 | 1 | 4 | 4.7 | N#CC(CCCN1CCC(O)(c2cccnc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL141020 | 65924 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 411 | 7 | 1 | 4 | 4.7 | N#CC(CCCN1CCC(O)(c2cccnc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| 10132885 | 349159 | 0 | None | 7 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 355 | 3 | 1 | 3 | 4.7 | Cc1ccc(N2C(=O)C(O)=C(C(=O)C(C)(C)C)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4569870 | 349159 | 0 | None | 7 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 355 | 3 | 1 | 3 | 4.7 | Cc1ccc(N2C(=O)C(O)=C(C(=O)C(C)(C)C)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 10132885 | 349159 | 0 | None | 7 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 355 | 3 | 1 | 3 | 4.7 | Cc1ccc(N2C(=O)C(O)=C(C(=O)C(C)(C)C)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4569870 | 349159 | 0 | None | 7 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 355 | 3 | 1 | 3 | 4.7 | Cc1ccc(N2C(=O)C(O)=C(C(=O)C(C)(C)C)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 10076510 | 25915 | 0 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 433 | 6 | 1 | 2 | 6.0 | C[N+]1(CCCC(C#N)c2ccc3ccccc3c2)CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm990316l | |||
| CHEMBL1180795 | 25915 | 0 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 433 | 6 | 1 | 2 | 6.0 | C[N+]1(CCCC(C#N)c2ccc3ccccc3c2)CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm990316l | |||
| 9850002 | 78565 | 0 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 532 | 5 | 1 | 4 | 6.6 | N#CC1(CCCN2CCC(O)(c3ccc(Br)cc3)CC2)c2ccccc2CSc2ccccc21 | 10.1021/jm990316l | |||
| CHEMBL143350 | 78565 | 0 | None | None | None | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 532 | 5 | 1 | 4 | 6.6 | N#CC1(CCCN2CCC(O)(c3ccc(Br)cc3)CC2)c2ccccc2CSc2ccccc21 | 10.1021/jm990316l | |||
| 68556971 | 335034 | 0 | None | None | None | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 474 | 7 | 2 | 6 | 3.3 | COc1cc(N2CCC(C(Cn3nc(C(F)(F)F)cc3C)NC(=O)CO)CC2)ccc1Cl | nan | |||
| CHEMBL4449145 | 335034 | 0 | None | None | None | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 474 | 7 | 2 | 6 | 3.3 | COc1cc(N2CCC(C(Cn3nc(C(F)(F)F)cc3C)NC(=O)CO)CC2)ccc1Cl | nan | |||
| 68556936 | 336854 | 0 | None | None | None | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 401 | 5 | 2 | 7 | 3.0 | COc1cc(N2CCC(C(O)Cn3nc(N)c4cccnc43)CC2)ccc1Cl | nan | |||
| CHEMBL4475524 | 336854 | 0 | None | None | None | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 401 | 5 | 2 | 7 | 3.0 | COc1cc(N2CCC(C(O)Cn3nc(N)c4cccnc43)CC2)ccc1Cl | nan | |||
| 10530837 | 78923 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 556 | 5 | 1 | 4 | 7.5 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccccc2CSc2ccccc21 | 10.1021/jm990316l | |||
| CHEMBL143814 | 78923 | 0 | None | None | None | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 556 | 5 | 1 | 4 | 7.5 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccccc2CSc2ccccc21 | 10.1021/jm990316l | |||
| 10293022 | 335639 | 7 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 377 | 3 | 1 | 3 | 4.1 | CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4457687 | 335639 | 7 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 377 | 3 | 1 | 3 | 4.1 | CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 10554359 | 77766 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 536 | 7 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(I)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL142676 | 77766 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 536 | 7 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(I)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| 10766333 | 78619 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 458 | 5 | 1 | 4 | 6.0 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2Oc2ccccc21 | 10.1021/jm990316l | |||
| CHEMBL143449 | 78619 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 458 | 5 | 1 | 4 | 6.0 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2Oc2ccccc21 | 10.1021/jm990316l | |||
| 10690854 | 66372 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 374 | 6 | 1 | 4 | 4.8 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccsc1 | 10.1021/jm990316l | |||
| CHEMBL141387 | 66372 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 374 | 6 | 1 | 4 | 4.8 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccsc1 | 10.1021/jm990316l | |||
| 10293022 | 335639 | 7 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 377 | 3 | 1 | 3 | 4.1 | CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4457687 | 335639 | 7 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 377 | 3 | 1 | 3 | 4.1 | CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 5311125 | 78652 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 488 | 5 | 1 | 4 | 6.5 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2CSc2ccccc21 | 10.1021/jm990316l | |||
| CHEMBL143492 | 78652 | 0 | None | None | None | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 488 | 5 | 1 | 4 | 6.5 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2CSc2ccccc21 | 10.1021/jm990316l | |||
| 10623381 | 40784 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 448 | 8 | 2 | 3 | 5.3 | NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL125111 | 40784 | 0 | None | None | None | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 448 | 8 | 2 | 3 | 5.3 | NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| 12093162 | 347425 | 0 | None | -1 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 329 | 4 | 1 | 4 | 3.4 | COc1ccc(N2C(=O)C(O)=C(C(C)=O)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4526524 | 347425 | 0 | None | -1 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 329 | 4 | 1 | 4 | 3.4 | COc1ccc(N2C(=O)C(O)=C(C(C)=O)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 71457815 | 174973 | 0 | None | -50 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 416 | 5 | 1 | 5 | 3.8 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207091 | 174973 | 0 | None | -50 | 3 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 416 | 5 | 1 | 5 | 3.8 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cccc(C(F)(F)F)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 12093162 | 347425 | 0 | None | -1 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 329 | 4 | 1 | 4 | 3.4 | COc1ccc(N2C(=O)C(O)=C(C(C)=O)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4526524 | 347425 | 0 | None | -1 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 329 | 4 | 1 | 4 | 3.4 | COc1ccc(N2C(=O)C(O)=C(C(C)=O)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 9967349 | 347178 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 331 | 3 | 1 | 3 | 3.8 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4519533 | 347178 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 331 | 3 | 1 | 3 | 3.8 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 155559153 | 348818 | 0 | None | 2 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 457 | 4 | 1 | 3 | 5.6 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1)c1ccccc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4561618 | 348818 | 0 | None | 2 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 457 | 4 | 1 | 3 | 5.6 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1)c1ccccc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 155559153 | 348818 | 0 | None | 2 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 457 | 4 | 1 | 3 | 5.6 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1)c1ccccc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4561618 | 348818 | 0 | None | 2 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 457 | 4 | 1 | 3 | 5.6 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1)c1ccccc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 9902578 | 335894 | 0 | None | 4 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 341 | 5 | 1 | 3 | 4.5 | CCCC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4461627 | 335894 | 0 | None | 4 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 341 | 5 | 1 | 3 | 4.5 | CCCC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 9902578 | 335894 | 0 | None | 4 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 341 | 5 | 1 | 3 | 4.5 | CCCC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4461627 | 335894 | 0 | None | 4 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 341 | 5 | 1 | 3 | 4.5 | CCCC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 9967349 | 347178 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 331 | 3 | 1 | 3 | 3.8 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4519533 | 347178 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 331 | 3 | 1 | 3 | 3.8 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2F)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 44361881 | 333207 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 500 | 5 | 1 | 3 | 5.9 | N#CC1(CCCN2CCC(O)(c3ccc(Br)cc3)CC2)c2ccccc2Cc2ccccc21 | 10.1021/jm990316l | |||
| CHEMBL435485 | 333207 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 500 | 5 | 1 | 3 | 5.9 | N#CC1(CCCN2CCC(O)(c3ccc(Br)cc3)CC2)c2ccccc2Cc2ccccc21 | 10.1021/jm990316l | |||
| 24764465 | 349756 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 556 | 7 | 2 | 6 | 5.0 | COc1cc(N2CCC(C(Cn3nc(C(F)(F)F)c(Cl)c3C)NC(=O)[C@@H](C)O)CC2)c(Cl)cc1Cl | nan | |||
| CHEMBL4583778 | 349756 | 0 | None | None | None | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 556 | 7 | 2 | 6 | 5.0 | COc1cc(N2CCC(C(Cn3nc(C(F)(F)F)c(Cl)c3C)NC(=O)[C@@H](C)O)CC2)c(Cl)cc1Cl | nan | |||
| 44537841 | 1390 | 22 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | nan | |||
| 57889181 | 1390 | 22 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | nan | |||
| 9497 | 1390 | 22 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | nan | |||
| CHEMBL2398716 | 1390 | 22 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | nan | |||
| CHEMBL3334824 | 1390 | 22 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | nan | |||
| 155539148 | 346931 | 0 | None | 3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 327 | 4 | 1 | 3 | 4.1 | CCC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4513770 | 346931 | 0 | None | 3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 327 | 4 | 1 | 3 | 4.1 | CCC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 155539148 | 346931 | 0 | None | 3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 327 | 4 | 1 | 3 | 4.1 | CCC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4513770 | 346931 | 0 | None | 3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 327 | 4 | 1 | 3 | 4.1 | CCC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 22725647 | 347783 | 0 | None | -3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 347 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4535696 | 347783 | 0 | None | -3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 347 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 10501338 | 239661 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 402 | 6 | 1 | 3 | 5.4 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Cl | 10.1021/jm990316l | |||
| CHEMBL356764 | 239661 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 402 | 6 | 1 | 3 | 5.4 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Cl | 10.1021/jm990316l | |||
| 155545804 | 347591 | 0 | None | 5 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 355 | 6 | 1 | 3 | 4.9 | CCCCC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4530510 | 347591 | 0 | None | 5 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 355 | 6 | 1 | 3 | 4.9 | CCCCC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 22725647 | 347783 | 0 | None | -3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 347 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4535696 | 347783 | 0 | None | -3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 347 | 3 | 1 | 3 | 4.3 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 155545804 | 347591 | 0 | None | 5 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 355 | 6 | 1 | 3 | 4.9 | CCCCC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4530510 | 347591 | 0 | None | 5 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 355 | 6 | 1 | 3 | 4.9 | CCCCC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 71450658 | 174980 | 0 | None | -31 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 450 | 5 | 1 | 5 | 4.7 | O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207098 | 174980 | 0 | None | -31 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 450 | 5 | 1 | 5 | 4.7 | O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 71454248 | 174983 | 0 | None | -25 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 422 | 5 | 1 | 6 | 4.1 | O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1ccc(Cl)s1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207100 | 174983 | 0 | None | -25 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 422 | 5 | 1 | 6 | 4.1 | O=S(=O)(Nc1cc(Cl)c(Cl)cc1Cn1ccnn1)c1ccc(Cl)s1 | 10.1016/j.bmcl.2012.09.020 | |||
| 10649043 | 78046 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 499 | 5 | 1 | 4 | 5.5 | CN1C(=O)c2ccccc2C(C#N)(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc21 | 10.1021/jm990316l | |||
| CHEMBL142925 | 78046 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 499 | 5 | 1 | 4 | 5.5 | CN1C(=O)c2ccccc2C(C#N)(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc21 | 10.1021/jm990316l | |||
| 10717972 | 238111 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 440 | 8 | 1 | 5 | 4.4 | CCOC(=O)C(C#N)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL344324 | 238111 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 440 | 8 | 1 | 5 | 4.4 | CCOC(=O)C(C#N)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/jm990316l | |||
| 10647579 | 78866 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 458 | 6 | 1 | 3 | 5.4 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1c(F)c(F)c(F)c(F)c1F | 10.1021/jm990316l | |||
| CHEMBL143772 | 78866 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 458 | 6 | 1 | 3 | 5.4 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1c(F)c(F)c(F)c(F)c1F | 10.1021/jm990316l | |||
| 9956488 | 238012 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 472 | 5 | 1 | 4 | 5.8 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2COc2ccccc21 | 10.1021/jm990316l | |||
| CHEMBL343511 | 238012 | 0 | None | None | None | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 472 | 5 | 1 | 4 | 5.8 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2COc2ccccc21 | 10.1021/jm990316l | |||
| 10672205 | 238137 | 0 | None | None | None | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 474 | 9 | 1 | 4 | 6.3 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(OCc2ccccc2)cc1 | 10.1021/jm990316l | |||
| CHEMBL344499 | 238137 | 0 | None | None | None | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 474 | 9 | 1 | 4 | 6.3 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(OCc2ccccc2)cc1 | 10.1021/jm990316l | |||
| 10670785 | 66739 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 440 | 8 | 1 | 4 | 5.3 | COc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1021/jm990316l | |||
| CHEMBL141713 | 66739 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 440 | 8 | 1 | 4 | 5.3 | COc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1021/jm990316l | |||
| 44199443 | 335090 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 378 | 6 | 2 | 3 | 4.0 | CCC(NC(=O)C1CCCC1)C(O)C1CCN(c2ccc(Cl)cc2)CC1 | nan | |||
| CHEMBL4449875 | 335090 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 378 | 6 | 2 | 3 | 4.0 | CCC(NC(=O)C1CCCC1)C(O)C1CCN(c2ccc(Cl)cc2)CC1 | nan | |||
| 10597049 | 66859 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 398 | 7 | 1 | 4 | 4.7 | COc1ccc(C(C#N)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1 | 10.1021/jm990316l | |||
| CHEMBL141817 | 66859 | 0 | None | None | None | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 398 | 7 | 1 | 4 | 4.7 | COc1ccc(C(C#N)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1 | 10.1021/jm990316l | |||
| 10837160 | 239734 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 446 | 6 | 1 | 3 | 5.5 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Br | 10.1021/jm990316l | |||
| CHEMBL357445 | 239734 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 446 | 6 | 1 | 3 | 5.5 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Br | 10.1021/jm990316l | |||
| 10596333 | 67268 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 386 | 6 | 1 | 3 | 4.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1F | 10.1021/jm990316l | |||
| CHEMBL142160 | 67268 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 386 | 6 | 1 | 3 | 4.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1F | 10.1021/jm990316l | |||
| 9902204 | 334685 | 6 | None | -2 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 333 | 3 | 1 | 3 | 4.0 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4443909 | 334685 | 6 | None | -2 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 333 | 3 | 1 | 3 | 4.0 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 10503474 | 77800 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 444 | 7 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2cccc(Cl)c2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL142713 | 77800 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 444 | 7 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2cccc(Cl)c2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| 15985912 | 174963 | 0 | None | -9 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 416 | 5 | 1 | 5 | 4.1 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207081 | 174963 | 0 | None | -9 | 3 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 416 | 5 | 1 | 5 | 4.1 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 71214709 | 174966 | 0 | None | -14 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 431 | 5 | 1 | 6 | 3.8 | Cc1nnnn1Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207084 | 174966 | 0 | None | -14 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 431 | 5 | 1 | 6 | 3.8 | Cc1nnnn1Cc1ccc(Cl)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 71454246 | 174971 | 0 | None | -7 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 376 | 5 | 1 | 5 | 3.4 | Cc1ccc(S(=O)(=O)Nc2cc(Cl)ccc2Cn2ccnn2)cc1C | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207089 | 174971 | 0 | None | -7 | 3 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 376 | 5 | 1 | 5 | 3.4 | Cc1ccc(S(=O)(=O)Nc2cc(Cl)ccc2Cn2ccnn2)cc1C | 10.1016/j.bmcl.2012.09.020 | |||
| 87494453 | 348986 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 544 | 7 | 1 | 5 | 5.6 | COc1cc(N2CCC(C(Cn3nc(C(F)(F)F)c(Cl)c3C)NC(=O)CF)CC2)c(Cl)cc1Cl | nan | |||
| CHEMBL4565880 | 348986 | 0 | None | None | None | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 544 | 7 | 1 | 5 | 5.6 | COc1cc(N2CCC(C(Cn3nc(C(F)(F)F)c(Cl)c3C)NC(=O)CF)CC2)c(Cl)cc1Cl | nan | |||
| 9902204 | 334685 | 6 | None | -2 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 333 | 3 | 1 | 3 | 4.0 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4443909 | 334685 | 6 | None | -2 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 333 | 3 | 1 | 3 | 4.0 | CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 155513751 | 334368 | 0 | None | 7 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 341 | 4 | 1 | 3 | 4.3 | Cc1ccc(N2C(=O)C(O)=C(C(=O)C(C)C)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4439354 | 334368 | 0 | None | 7 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 341 | 4 | 1 | 3 | 4.3 | Cc1ccc(N2C(=O)C(O)=C(C(=O)C(C)C)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 10694874 | 78460 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 450 | 7 | 1 | 3 | 6.4 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)C1CCCCC1 | 10.1021/jm990316l | |||
| CHEMBL143266 | 78460 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 450 | 7 | 1 | 3 | 6.4 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)C1CCCCC1 | 10.1021/jm990316l | |||
| 10524463 | 329801 | 0 | None | None | None | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 390 | 9 | 1 | 3 | 5.3 | CCCCC1(O)CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm990316l | |||
| CHEMBL422115 | 329801 | 0 | None | None | None | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 390 | 9 | 1 | 3 | 5.3 | CCCCC1(O)CCN(CCCC(C#N)(c2ccccc2)c2ccccc2)CC1 | 10.1021/jm990316l | |||
| 10838033 | 237872 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 468 | 6 | 1 | 4 | 6.0 | N#CC1(CCCN2CCC(O)(Cc3ccccc3)CC2)c2ccccc2CSc2ccccc21 | 10.1021/jm990316l | |||
| CHEMBL342721 | 237872 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 468 | 6 | 1 | 4 | 6.0 | N#CC1(CCCN2CCC(O)(Cc3ccccc3)CC2)c2ccccc2CSc2ccccc21 | 10.1021/jm990316l | |||
| 10814504 | 239657 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 477 | 8 | 1 | 4 | 5.6 | COC(=O)C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL356718 | 239657 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 477 | 8 | 1 | 4 | 5.6 | COC(=O)C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| 9845614 | 239888 | 19 | None | None | None | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 430 | 6 | 1 | 3 | 5.5 | N#CC(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL357919 | 239888 | 19 | None | None | None | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 430 | 6 | 1 | 3 | 5.5 | N#CC(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| 155513751 | 334368 | 0 | None | 7 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 341 | 4 | 1 | 3 | 4.3 | Cc1ccc(N2C(=O)C(O)=C(C(=O)C(C)C)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4439354 | 334368 | 0 | None | 7 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 341 | 4 | 1 | 3 | 4.3 | Cc1ccc(N2C(=O)C(O)=C(C(=O)C(C)C)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 22335694 | 336091 | 0 | None | -2 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 327 | 3 | 1 | 3 | 4.0 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)c(C)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4464639 | 336091 | 0 | None | -2 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 327 | 3 | 1 | 3 | 4.0 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)c(C)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 10571296 | 78952 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 371 | 6 | 1 | 4 | 4.0 | Cn1cccc1C(C#N)CCCN1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm990316l | |||
| CHEMBL143840 | 78952 | 0 | None | None | None | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 371 | 6 | 1 | 4 | 4.0 | Cn1cccc1C(C#N)CCCN1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm990316l | |||
| 22335694 | 336091 | 0 | None | -2 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 327 | 3 | 1 | 3 | 4.0 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)c(C)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4464639 | 336091 | 0 | None | -2 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 327 | 3 | 1 | 3 | 4.0 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)c(C)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 9804868 | 67454 | 1 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 472 | 5 | 1 | 4 | 6.0 | N#CC1(CCCN2CCC(O)(c3ccc(F)cc3)CC2)c2ccccc2CSc2ccccc21 | 10.1021/jm990316l | |||
| CHEMBL142318 | 67454 | 1 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 472 | 5 | 1 | 4 | 6.0 | N#CC1(CCCN2CCC(O)(c3ccc(F)cc3)CC2)c2ccccc2CSc2ccccc21 | 10.1021/jm990316l | |||
| 9956380 | 332961 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 470 | 5 | 1 | 3 | 6.0 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2CCc2ccccc21 | 10.1021/jm990316l | |||
| CHEMBL433746 | 332961 | 0 | None | None | None | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 470 | 5 | 1 | 3 | 6.0 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2CCc2ccccc21 | 10.1021/jm990316l | |||
| 10786180 | 78936 | 0 | None | None | None | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 382 | 6 | 1 | 3 | 4.9 | CC(C#N)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL143825 | 78936 | 0 | None | None | None | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 382 | 6 | 1 | 3 | 4.9 | CC(C#N)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/jm990316l | |||
| 10573219 | 79060 | 0 | None | None | None | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 402 | 6 | 1 | 3 | 5.4 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1 | 10.1021/jm990316l | |||
| CHEMBL143942 | 79060 | 0 | None | None | None | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 402 | 6 | 1 | 3 | 5.4 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1 | 10.1021/jm990316l | |||
| 22335665 | 347564 | 0 | None | 1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 331 | 3 | 1 | 3 | 3.8 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)c(F)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4529804 | 347564 | 0 | None | 1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 331 | 3 | 1 | 3 | 3.8 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)c(F)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 12093163 | 348453 | 0 | None | -1 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 313 | 3 | 1 | 3 | 3.7 | CC(=O)C1=C(O)C(=O)N(c2cccc(C)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4552420 | 348453 | 0 | None | -1 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 313 | 3 | 1 | 3 | 3.7 | CC(=O)C1=C(O)C(=O)N(c2cccc(C)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 22335665 | 347564 | 0 | None | 1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 331 | 3 | 1 | 3 | 3.8 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)c(F)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4529804 | 347564 | 0 | None | 1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 331 | 3 | 1 | 3 | 3.8 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)c(F)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 10695227 | 78802 | 0 | None | None | None | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 458 | 9 | 1 | 6 | 4.7 | COc1cc(C(C#N)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc(OC)c1OC | 10.1021/jm990316l | |||
| CHEMBL143690 | 78802 | 0 | None | None | None | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 458 | 9 | 1 | 6 | 4.7 | COc1cc(C(C#N)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc(OC)c1OC | 10.1021/jm990316l | |||
| 10195332 | 163993 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 461 | 9 | 4 | 6 | 3.4 | CC(=O)Nc1ccc(O)cc1OC[C@@](C)(O)CNC1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1021/jm300682j | |||
| CHEMBL2178570 | 163993 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 461 | 9 | 4 | 6 | 3.4 | CC(=O)Nc1ccc(O)cc1OC[C@@](C)(O)CNC1CCN(Cc2ccc(Cl)cc2)CC1 | 10.1021/jm300682j | |||
| 2352 | 195309 | 69 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 444 | 6 | 3 | 9 | 0.9 | Cc1nnc(C(=O)NC(C)(C)c2nc(C(=O)NCc3ccc(F)cc3)c(O)c(=O)n2C)o1 | 10.1021/jm300682j | |||
| 54671008 | 195309 | 69 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 444 | 6 | 3 | 9 | 0.9 | Cc1nnc(C(=O)NC(C)(C)c2nc(C(=O)NCc3ccc(F)cc3)c(O)c(=O)n2C)o1 | 10.1021/jm300682j | |||
| CHEMBL254316 | 195309 | 69 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 444 | 6 | 3 | 9 | 0.9 | Cc1nnc(C(=O)NC(C)(C)c2nc(C(=O)NCc3ccc(F)cc3)c(O)c(=O)n2C)o1 | 10.1021/jm300682j | |||
| DB06817 | 195309 | 69 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 444 | 6 | 3 | 9 | 0.9 | Cc1nnc(C(=O)NC(C)(C)c2nc(C(=O)NCc3ccc(F)cc3)c(O)c(=O)n2C)o1 | 10.1021/jm300682j | |||
| 155521447 | 335135 | 0 | None | 2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 421 | 4 | 1 | 3 | 4.7 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4450561 | 335135 | 0 | None | 2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 421 | 4 | 1 | 3 | 4.7 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 87496446 | 335323 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 542 | 7 | 2 | 6 | 4.6 | COc1cc(N2CCC(C(Cn3nc(C(F)(F)F)c(Cl)c3C)NC(=O)CO)CC2)c(Cl)cc1Cl | nan | |||
| CHEMBL4452884 | 335323 | 0 | None | None | None | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 542 | 7 | 2 | 6 | 4.6 | COc1cc(N2CCC(C(Cn3nc(C(F)(F)F)c(Cl)c3C)NC(=O)CO)CC2)c(Cl)cc1Cl | nan | |||
| 155521447 | 335135 | 0 | None | 2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 421 | 4 | 1 | 3 | 4.7 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4450561 | 335135 | 0 | None | 2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 421 | 4 | 1 | 3 | 4.7 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 155514261 | 334402 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 493 | 4 | 1 | 3 | 5.2 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1c1cccc(Br)c1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4439854 | 334402 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 493 | 4 | 1 | 3 | 5.2 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1c1cccc(Br)c1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 155514261 | 334402 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 493 | 4 | 1 | 3 | 5.2 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1c1cccc(Br)c1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4439854 | 334402 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 493 | 4 | 1 | 3 | 5.2 | O=C(C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1c1cccc(Br)c1)C1CC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 12093163 | 348453 | 0 | None | -1 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 313 | 3 | 1 | 3 | 3.7 | CC(=O)C1=C(O)C(=O)N(c2cccc(C)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4552420 | 348453 | 0 | None | -1 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 313 | 3 | 1 | 3 | 3.7 | CC(=O)C1=C(O)C(=O)N(c2cccc(C)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 15985914 | 174962 | 0 | None | -8 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 4.4 | O=S(=O)(Nc1cc(Cl)ccc1Cn1nnnc1C1CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207080 | 174962 | 0 | None | -8 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 457 | 6 | 1 | 6 | 4.4 | O=S(=O)(Nc1cc(Cl)ccc1Cn1nnnc1C1CC1)c1ccc(Cl)c(Cl)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 71450657 | 174976 | 0 | None | -19 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 422 | 5 | 1 | 6 | 4.1 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cc(Cl)c(Cl)s1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207094 | 174976 | 0 | None | -19 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 422 | 5 | 1 | 6 | 4.1 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1cc(Cl)c(Cl)s1 | 10.1016/j.bmcl.2012.09.020 | |||
| 10789482 | 67301 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 444 | 9 | 1 | 3 | 5.9 | N#CC(CCCCl)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL142191 | 67301 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 444 | 9 | 1 | 3 | 5.9 | N#CC(CCCCl)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/jm990316l | |||
| 10549688 | 330251 | 0 | None | None | None | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 413 | 7 | 1 | 5 | 4.6 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc([N+](=O)[O-])c1 | 10.1021/jm990316l | |||
| CHEMBL423734 | 330251 | 0 | None | None | None | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 413 | 7 | 1 | 5 | 4.6 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc([N+](=O)[O-])c1 | 10.1021/jm990316l | |||
| 9889700 | 237386 | 15 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 444 | 7 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL34166 | 237386 | 15 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 444 | 7 | 1 | 3 | 5.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| 9967465 | 336612 | 7 | None | -2 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 333 | 3 | 1 | 3 | 4.0 | CC(=O)C1=C(O)C(=O)N(c2cccc(Cl)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4472384 | 336612 | 7 | None | -2 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 333 | 3 | 1 | 3 | 4.0 | CC(=O)C1=C(O)C(=O)N(c2cccc(Cl)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 10764931 | 238036 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 426 | 7 | 1 | 5 | 4.0 | COC(=O)C(C#N)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL343680 | 238036 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 426 | 7 | 1 | 5 | 4.0 | COC(=O)C(C#N)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/jm990316l | |||
| 10667913 | 67271 | 0 | None | None | None | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 386 | 6 | 1 | 3 | 4.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1021/jm990316l | |||
| CHEMBL142161 | 67271 | 0 | None | None | None | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 386 | 6 | 1 | 3 | 4.9 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 | 10.1021/jm990316l | |||
| 2868511 | 86047 | 10 | None | None | None | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 337 | 4 | 1 | 4 | 3.5 | COc1ccc(C2C(C(C)=O)=C(O)C(=O)N2c2ccc(C)cc2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL1500746 | 86047 | 10 | None | None | None | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 337 | 4 | 1 | 4 | 3.5 | COc1ccc(C2C(C(C)=O)=C(O)C(=O)N2c2ccc(C)cc2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 10499297 | 78225 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 368 | 6 | 1 | 3 | 4.7 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL143059 | 78225 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 368 | 6 | 1 | 3 | 4.7 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/jm990316l | |||
| 9870787 | 78354 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 504 | 5 | 1 | 4 | 5.5 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2C[S+]([O-])c2ccccc21 | 10.1021/jm990316l | |||
| CHEMBL143173 | 78354 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 504 | 5 | 1 | 4 | 5.5 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2C[S+]([O-])c2ccccc21 | 10.1021/jm990316l | |||
| 9857981 | 335332 | 7 | None | 1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 313 | 3 | 1 | 3 | 3.7 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4453024 | 335332 | 7 | None | 1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 313 | 3 | 1 | 3 | 3.7 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 9945265 | 335724 | 0 | None | 1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 327 | 3 | 1 | 3 | 4.1 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4459033 | 335724 | 0 | None | 1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 327 | 3 | 1 | 3 | 4.1 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 2868511 | 86047 | 10 | None | None | None | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 337 | 4 | 1 | 4 | 3.5 | COc1ccc(C2C(C(C)=O)=C(O)C(=O)N2c2ccc(C)cc2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL1500746 | 86047 | 10 | None | None | None | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 337 | 4 | 1 | 4 | 3.5 | COc1ccc(C2C(C(C)=O)=C(O)C(=O)N2c2ccc(C)cc2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 9967465 | 336612 | 7 | None | -2 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 333 | 3 | 1 | 3 | 4.0 | CC(=O)C1=C(O)C(=O)N(c2cccc(Cl)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4472384 | 336612 | 7 | None | -2 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 333 | 3 | 1 | 3 | 4.0 | CC(=O)C1=C(O)C(=O)N(c2cccc(Cl)c2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 9857981 | 335332 | 7 | None | 1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 313 | 3 | 1 | 3 | 3.7 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4453024 | 335332 | 7 | None | 1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 313 | 3 | 1 | 3 | 3.7 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 9945265 | 335724 | 0 | None | 1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 327 | 3 | 1 | 3 | 4.1 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4459033 | 335724 | 0 | None | 1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 327 | 3 | 1 | 3 | 4.1 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 9869274 | 238077 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 468 | 5 | 1 | 3 | 6.4 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2C=Cc2ccccc21 | 10.1021/jm990316l | |||
| CHEMBL344073 | 238077 | 0 | None | None | None | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 468 | 5 | 1 | 3 | 6.4 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2C=Cc2ccccc21 | 10.1021/jm990316l | |||
| 9924108 | 336304 | 0 | None | 2 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 4.5 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4467708 | 336304 | 0 | None | 2 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 4.5 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 9924108 | 336304 | 0 | None | 2 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 4.5 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4467708 | 336304 | 0 | None | 2 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 4.5 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1C1CCCCCCC1 | 10.1021/acs.jmedchem.8b00605 | |||
| 10737864 | 240173 | 0 | None | None | None | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 4.1 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccn1 | 10.1021/jm990316l | |||
| CHEMBL358596 | 240173 | 0 | None | None | None | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 369 | 6 | 1 | 4 | 4.1 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccn1 | 10.1021/jm990316l | |||
| 11801020 | 26518 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 434 | 7 | 1 | 1 | 6.4 | C[N+]1(CCCC(c2ccccc2)c2ccccc2)CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm990316l | |||
| CHEMBL1184558 | 26518 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 434 | 7 | 1 | 1 | 6.4 | C[N+]1(CCCC(c2ccccc2)c2ccccc2)CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm990316l | |||
| 24863549 | 334962 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 526 | 6 | 1 | 5 | 5.6 | COc1cc(N2CCC(C(Cn3nc(C(F)(F)F)c(Cl)c3C)NC(C)=O)CC2)c(Cl)cc1Cl | nan | |||
| CHEMBL4448154 | 334962 | 0 | None | None | None | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 526 | 6 | 1 | 5 | 5.6 | COc1cc(N2CCC(C(Cn3nc(C(F)(F)F)c(Cl)c3C)NC(C)=O)CC2)c(Cl)cc1Cl | nan | |||
| 10768343 | 237538 | 0 | None | None | None | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 522 | 5 | 1 | 4 | 6.9 | N#CC1(CCCN2CCC(O)(c3cccc(C(F)(F)F)c3)CC2)c2ccccc2CSc2ccccc21 | 10.1021/jm990316l | |||
| CHEMBL341769 | 237538 | 0 | None | None | None | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 522 | 5 | 1 | 4 | 6.9 | N#CC1(CCCN2CCC(O)(c3cccc(C(F)(F)F)c3)CC2)c2ccccc2CSc2ccccc21 | 10.1021/jm990316l | |||
| 155526680 | 335670 | 0 | None | 3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 467 | 3 | 1 | 3 | 4.8 | CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1c1cccc(Br)c1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4458295 | 335670 | 0 | None | 3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 467 | 3 | 1 | 3 | 4.8 | CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1c1cccc(Br)c1 | 10.1021/acs.jmedchem.8b00605 | |||
| 155526680 | 335670 | 0 | None | 3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 467 | 3 | 1 | 3 | 4.8 | CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1c1cccc(Br)c1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4458295 | 335670 | 0 | None | 3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 467 | 3 | 1 | 3 | 4.8 | CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1c1cccc(Br)c1 | 10.1021/acs.jmedchem.8b00605 | |||
| 3794409 | 335301 | 6 | None | 3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 4.1 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4452558 | 335301 | 6 | None | 3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 4.1 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 3794409 | 335301 | 6 | None | 3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 4.1 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4452558 | 335301 | 6 | None | 3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 341 | 3 | 1 | 3 | 4.1 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1ccc(Cl)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 9870787 | 78354 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 504 | 5 | 1 | 4 | 5.5 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2C[S+]([O-])c2ccccc21 | 10.1021/jm990316l | |||
| CHEMBL143173 | 78354 | 0 | None | None | None | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 504 | 5 | 1 | 4 | 5.5 | N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2C[S+]([O-])c2ccccc21 | 10.1021/jm990316l | |||
| 10813846 | 65055 | 0 | None | None | None | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 460 | 7 | 1 | 3 | 6.4 | N#CC(CCCN1CCC(O)(c2ccc3ccccc3c2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL140270 | 65055 | 0 | None | None | None | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 460 | 7 | 1 | 3 | 6.4 | N#CC(CCCN1CCC(O)(c2ccc3ccccc3c2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| 3497 | 2447 | 26 | None | -1 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1021/jm300682j | |||
| 44309353 | 2447 | 26 | None | -1 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1021/jm300682j | |||
| 5311123 | 2447 | 26 | None | -1 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1021/jm300682j | |||
| CHEMBL1628706 | 2447 | 26 | None | -1 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1021/jm300682j | |||
| CHEMBL308473 | 2447 | 26 | None | -1 | 3 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 10.1021/jm300682j | |||
| 10766998 | 77515 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.5 | COc1ccc(C(C#N)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1Br | 10.1021/jm990316l | |||
| CHEMBL142468 | 77515 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 476 | 7 | 1 | 4 | 5.5 | COc1ccc(C(C#N)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1Br | 10.1021/jm990316l | |||
| 10693630 | 160348 | 0 | None | None | None | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 424 | 8 | 1 | 3 | 5.3 | N#CC(CCCN1CCC(CO)(c2ccccc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL2112830 | 160348 | 0 | None | None | None | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 424 | 8 | 1 | 3 | 5.3 | N#CC(CCCN1CCC(CO)(c2ccccc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| 155548977 | 347872 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 375 | 4 | 1 | 3 | 5.0 | Cc1ccc(N2C(=O)C(O)=C(C(=O)c3ccccc3)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4538013 | 347872 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 375 | 4 | 1 | 3 | 5.0 | Cc1ccc(N2C(=O)C(O)=C(C(=O)c3ccccc3)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 155548977 | 347872 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 375 | 4 | 1 | 3 | 5.0 | Cc1ccc(N2C(=O)C(O)=C(C(=O)c3ccccc3)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4538013 | 347872 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 375 | 4 | 1 | 3 | 5.0 | Cc1ccc(N2C(=O)C(O)=C(C(=O)c3ccccc3)C2C2CCCCC2)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 10575889 | 67305 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 458 | 8 | 1 | 3 | 6.3 | N#CC(CCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL142199 | 67305 | 0 | None | None | None | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 458 | 8 | 1 | 3 | 6.3 | N#CC(CCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| 10643770 | 77891 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 384 | 6 | 2 | 4 | 4.4 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1O | 10.1021/jm990316l | |||
| CHEMBL142798 | 77891 | 0 | None | None | None | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 384 | 6 | 2 | 4 | 4.4 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1O | 10.1021/jm990316l | |||
| 71463165 | 174968 | 0 | None | -6 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 348 | 5 | 1 | 5 | 2.8 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccccc1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207086 | 174968 | 0 | None | -6 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 348 | 5 | 1 | 5 | 2.8 | O=S(=O)(Nc1cc(Cl)ccc1Cn1ccnn1)c1ccccc1 | 10.1016/j.bmcl.2012.09.020 | |||
| 71456007 | 174974 | 0 | None | -5 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 373 | 5 | 1 | 6 | 2.7 | N#Cc1cccc(S(=O)(=O)Nc2cc(Cl)ccc2Cn2ccnn2)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| CHEMBL2207092 | 174974 | 0 | None | -5 | 3 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 373 | 5 | 1 | 6 | 2.7 | N#Cc1cccc(S(=O)(=O)Nc2cc(Cl)ccc2Cn2ccnn2)c1 | 10.1016/j.bmcl.2012.09.020 | |||
| 10722083 | 144791 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 459 | 7 | 1 | 2 | 6.1 | C[N+]1(CCCC(C#N)(c2ccccc2)c2ccccc2)CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm990316l | |||
| CHEMBL199252 | 144791 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 459 | 7 | 1 | 2 | 6.1 | C[N+]1(CCCC(C#N)(c2ccccc2)c2ccccc2)CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm990316l | |||
| 3796276 | 335395 | 6 | None | 2 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 385 | 3 | 1 | 3 | 4.2 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1ccc(Br)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4453953 | 335395 | 6 | None | 2 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 385 | 3 | 1 | 3 | 4.2 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1ccc(Br)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 3796276 | 335395 | 6 | None | 2 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 385 | 3 | 1 | 3 | 4.2 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1ccc(Br)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| CHEMBL4453953 | 335395 | 6 | None | 2 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 385 | 3 | 1 | 3 | 4.2 | CC(=O)C1=C(O)C(=O)N(c2ccc(C)cc2)C1c1ccc(Br)cc1 | 10.1021/acs.jmedchem.8b00605 | |||
| 9959839 | 77841 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 574 | 10 | 4 | 4 | 5.4 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)NC1CCNCC1 | 10.1021/jm990316l | |||
| CHEMBL142752 | 77841 | 0 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 574 | 10 | 4 | 4 | 5.4 | O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)NC1CCNCC1 | 10.1021/jm990316l | |||
| 10525695 | 240103 | 0 | None | None | None | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 411 | 7 | 1 | 4 | 4.7 | N#CC(CCCN1CCC(O)(c2ccccn2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL358283 | 240103 | 0 | None | None | None | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 411 | 7 | 1 | 4 | 4.7 | N#CC(CCCN1CCC(O)(c2ccccn2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| 11798220 | 67386 | 0 | None | None | None | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 460 | 8 | 1 | 4 | 6.5 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Oc2ccccc2)c1 | 10.1021/jm990316l | |||
| CHEMBL142263 | 67386 | 0 | None | None | None | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 460 | 8 | 1 | 4 | 6.5 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Oc2ccccc2)c1 | 10.1021/jm990316l | |||
| 10789018 | 78655 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 435 | 7 | 1 | 4 | 5.1 | N#Cc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1021/jm990316l | |||
| CHEMBL143499 | 78655 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 435 | 7 | 1 | 4 | 5.1 | N#Cc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 | 10.1021/jm990316l | |||
| 10548809 | 237945 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 396 | 7 | 1 | 3 | 5.3 | CCC(C#N)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL343028 | 237945 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 396 | 7 | 1 | 3 | 5.3 | CCC(C#N)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 | 10.1021/jm990316l | |||
| 44199443 | 335090 | 0 | None | None | None | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 378 | 6 | 2 | 3 | 4.0 | CCC(NC(=O)C1CCCC1)C(O)C1CCN(c2ccc(Cl)cc2)CC1 | nan | |||
| CHEMBL4449875 | 335090 | 0 | None | None | None | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 378 | 6 | 2 | 3 | 4.0 | CCC(NC(=O)C1CCCC1)C(O)C1CCN(c2ccc(Cl)cc2)CC1 | nan | |||
| 10810107 | 80381 | 0 | None | None | None | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 384 | 6 | 2 | 4 | 4.4 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(O)cc1 | 10.1021/jm990316l | |||
| CHEMBL145106 | 80381 | 0 | None | None | None | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 384 | 6 | 2 | 4 | 4.4 | N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(O)cc1 | 10.1021/jm990316l | |||
| 10572669 | 238197 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 393 | 6 | 1 | 4 | 4.6 | N#Cc1ccccc1C(C#N)CCCN1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm990316l | |||
| CHEMBL344989 | 238197 | 0 | None | None | None | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 393 | 6 | 1 | 4 | 4.6 | N#Cc1ccccc1C(C#N)CCCN1CCC(O)(c2ccc(Cl)cc2)CC1 | 10.1021/jm990316l | |||
| 10576419 | 77690 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 472 | 9 | 1 | 3 | 6.7 | N#CC(CCCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| CHEMBL142620 | 77690 | 0 | None | None | None | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 472 | 9 | 1 | 3 | 6.7 | N#CC(CCCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 | 10.1021/jm990316l | |||
| 44537841 | 1390 | 22 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | Guide to Pharmacology | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 25101488 | |||
| 57889181 | 1390 | 22 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | Guide to Pharmacology | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 25101488 | |||
| 9497 | 1390 | 22 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | Guide to Pharmacology | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 25101488 | |||
| CHEMBL2398716 | 1390 | 22 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | Guide to Pharmacology | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 25101488 | |||
| CHEMBL3334824 | 1390 | 22 | None | None | None | Human | 9.0 | pIC50 | = | 9 | Binding | Guide to Pharmacology | 438 | 6 | 3 | 4 | 3.1 | O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C | 25101488 | |||
| 3497 | 2447 | 26 | None | None | None | Human | 8.0 | pKd | = | 8 | Binding | Guide to Pharmacology | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 12909630 | |||
| 44309353 | 2447 | 26 | None | None | None | Human | 8.0 | pKd | = | 8 | Binding | Guide to Pharmacology | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 12909630 | |||
| 5311123 | 2447 | 26 | None | None | None | Human | 8.0 | pKd | = | 8 | Binding | Guide to Pharmacology | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 12909630 | |||
| CHEMBL1628706 | 2447 | 26 | None | None | None | Human | 8.0 | pKd | = | 8 | Binding | Guide to Pharmacology | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 12909630 | |||
| CHEMBL308473 | 2447 | 26 | None | None | None | Human | 8.0 | pKd | = | 8 | Binding | Guide to Pharmacology | 482 | 11 | 4 | 6 | 2.5 | O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C | 12909630 | |||
| 764 | 7613 | 0 | None | None | None | Human | 8.2 | pKd | = | 8.2 | Binding | Guide to Pharmacology | None | None | None | None | 9336350 | |||||
| 763 | 7611 | 0 | None | None | None | Human | 8.4 | pKd | = | 8.4 | Binding | Guide to Pharmacology | None | None | None | None | 7545673 | |||||
| 763 | 7611 | 0 | None | None | None | Human | 8.4 | pKd | = | 8.4 | Binding | Guide to Pharmacology | None | None | None | None | 9115216 | |||||
| 763 | 7611 | 0 | None | None | None | Human | 8.4 | pKd | = | 8.4 | Binding | Guide to Pharmacology | None | None | None | None | 9336350 | |||||
| 765 | 7614 | 0 | None | None | None | Human | 9.2 | pKd | = | 9.2 | Binding | Guide to Pharmacology | None | None | None | None | 7545673 | |||||
| 766 | 7615 | 0 | None | None | None | Human | 8.3 | pKd | None | 8.3 | Binding | Guide to Pharmacology | None | None | None | None | 9115216 | |||||
| 762 | 7610 | 0 | None | None | None | Human | 9.4 | pKd | None | 9.4 | Binding | Guide to Pharmacology | None | None | None | None | 9336350 | |||||
| 2352 | 195309 | 69 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 444 | 6 | 3 | 9 | 0.9 | Cc1nnc(C(=O)NC(C)(C)c2nc(C(=O)NCc3ccc(F)cc3)c(O)c(=O)n2C)o1 | None | |||
| 54671008 | 195309 | 69 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 444 | 6 | 3 | 9 | 0.9 | Cc1nnc(C(=O)NC(C)(C)c2nc(C(=O)NCc3ccc(F)cc3)c(O)c(=O)n2C)o1 | None | |||
| CHEMBL254316 | 195309 | 69 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 444 | 6 | 3 | 9 | 0.9 | Cc1nnc(C(=O)NC(C)(C)c2nc(C(=O)NCc3ccc(F)cc3)c(O)c(=O)n2C)o1 | None | |||
| DB06817 | 195309 | 69 | None | None | None | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 444 | 6 | 3 | 9 | 0.9 | Cc1nnc(C(=O)NC(C)(C)c2nc(C(=O)NCc3ccc(F)cc3)c(O)c(=O)n2C)o1 | None | |||
| 753 | 1716 | 0 | None | 1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | None | None | None | None | 12381680 | |||||
| Q16627 | 1716 | 0 | None | 1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | Guide to Pharmacology | None | None | None | None | 12381680 | |||||
| 757 | 1781 | 0 | None | -112 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | None | None | None | None | 12381680 | |||||
| 757 | 1781 | 0 | None | -112 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | None | None | None | None | 8530354 | |||||
| P13236 | 1781 | 0 | None | -112 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | None | None | None | None | 12381680 | |||||
| P13236 | 1781 | 0 | None | -112 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | None | None | None | None | 8530354 | |||||
| 758 | 1785 | 0 | None | -89 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | None | None | None | None | 8530354 | |||||
| 758 | 1785 | 0 | None | -89 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | None | None | None | None | 9624164 | |||||
| P13501 | 1785 | 0 | None | -89 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | None | None | None | None | 8530354 | |||||
| P13501 | 1785 | 0 | None | -89 | 4 | Human | 7.5 | pKi | = | 7.5 | Binding | Guide to Pharmacology | None | None | None | None | 9624164 | |||||
| 759 | 1793 | 0 | None | -6 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 11994538 | |||||
| 759 | 1793 | 0 | None | -6 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 12381680 | |||||
| P80098 | 1793 | 0 | None | -6 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 11994538 | |||||
| P80098 | 1793 | 0 | None | -6 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | None | None | None | None | 12381680 | |||||
| 512282 | 1562 | 44 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10748002 | |||
| 767 | 1562 | 44 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10748002 | |||
| CHEMBL232656 | 1562 | 44 | None | None | None | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 434 | 6 | 2 | 4 | 3.1 | NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F | 10748002 | |||
| 755 | 1754 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | None | None | None | None | 12381680 | |||||
| P55773 | 1754 | 0 | None | None | None | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | None | None | None | None | 12381680 | |||||
| 756 | 1775 | 0 | None | 3 | 2 | Human | 9.0 | pKi | = | 9 | Binding | Guide to Pharmacology | None | None | None | None | 11170631 | |||||
| 756 | 1775 | 0 | None | 3 | 2 | Human | 9.0 | pKi | = | 9 | Binding | Guide to Pharmacology | None | None | None | None | 12381680 | |||||
| 756 | 1775 | 0 | None | 3 | 2 | Human | 9.0 | pKi | = | 9 | Binding | Guide to Pharmacology | None | None | None | None | 8530354 | |||||
| 756 | 1775 | 0 | None | 3 | 2 | Human | 9.0 | pKi | = | 9 | Binding | Guide to Pharmacology | None | None | None | None | 9624164 | |||||
| P10147 | 1775 | 0 | None | 3 | 2 | Human | 9.0 | pKi | = | 9 | Binding | Guide to Pharmacology | None | None | None | None | 11170631 | |||||
| P10147 | 1775 | 0 | None | 3 | 2 | Human | 9.0 | pKi | = | 9 | Binding | Guide to Pharmacology | None | None | None | None | 12381680 | |||||
| P10147 | 1775 | 0 | None | 3 | 2 | Human | 9.0 | pKi | = | 9 | Binding | Guide to Pharmacology | None | None | None | None | 8530354 | |||||
| P10147 | 1775 | 0 | None | 3 | 2 | Human | 9.0 | pKi | = | 9 | Binding | Guide to Pharmacology | None | None | None | None | 9624164 | |||||
| 760 | 3401 | 0 | None | -3 | 2 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | None | None | None | None | 11170631 | |||||
| 752 | 1464 | 0 | None | 12 | 2 | Human | 8.8 | pKi | None | 8.8 | Binding | Guide to Pharmacology | None | None | None | None | 11170631 | |||||