Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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ligand		 Fold
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GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
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Description		 Source

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16212950 3213 24 None None None Rat 9.0 pEC50 = 9.0 Functional
Agonist activity to ETA receptor in Sprague-Dawley rat aorta assessed as induction of vessel ring contractionAgonist activity to ETA receptor in Sprague-Dawley rat aorta assessed as induction of vessel ring contraction
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1016/s0014-2999(98)00891-7
989 3213 24 None None None Rat 9.0 pEC50 = 9.0 Functional
Agonist activity to ETA receptor in Sprague-Dawley rat aorta assessed as induction of vessel ring contractionAgonist activity to ETA receptor in Sprague-Dawley rat aorta assessed as induction of vessel ring contraction
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1016/s0014-2999(98)00891-7
CHEMBL3775234 3213 24 None None None Rat 9.0 pEC50 = 9.0 Functional
Agonist activity to ETA receptor in Sprague-Dawley rat aorta assessed as induction of vessel ring contractionAgonist activity to ETA receptor in Sprague-Dawley rat aorta assessed as induction of vessel ring contraction
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1016/s0014-2999(98)00891-7
P05305 3213 24 None None None Rat 9.0 pEC50 = 9.0 Functional
Agonist activity to ETA receptor in Sprague-Dawley rat aorta assessed as induction of vessel ring contractionAgonist activity to ETA receptor in Sprague-Dawley rat aorta assessed as induction of vessel ring contraction
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1016/s0014-2999(98)00891-7
P22387 3213 24 None None None Rat 9.0 pEC50 = 9.0 Functional
Agonist activity to ETA receptor in Sprague-Dawley rat aorta assessed as induction of vessel ring contractionAgonist activity to ETA receptor in Sprague-Dawley rat aorta assessed as induction of vessel ring contraction
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1016/s0014-2999(98)00891-7
P22388 3213 24 None None None Rat 9.0 pEC50 = 9.0 Functional
Agonist activity to ETA receptor in Sprague-Dawley rat aorta assessed as induction of vessel ring contractionAgonist activity to ETA receptor in Sprague-Dawley rat aorta assessed as induction of vessel ring contraction
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1016/s0014-2999(98)00891-7
14516 397 1 None -1 4 Rat 10.3 pIC50 = 10.3 Functional
Antagonist activity at ETA receptor in rat MMQ cells assessed as inhibition of phosphatidylinositol hydrolysis by myo-[3H]inositol radioactivity based assayAntagonist activity at ETA receptor in rat MMQ cells assessed as inhibition of phosphatidylinositol hydrolysis by myo-[3H]inositol radioactivity based assay
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1042/cs103s107s
9916235 397 1 None -1 4 Rat 10.3 pIC50 = 10.3 Functional
Antagonist activity at ETA receptor in rat MMQ cells assessed as inhibition of phosphatidylinositol hydrolysis by myo-[3H]inositol radioactivity based assayAntagonist activity at ETA receptor in rat MMQ cells assessed as inhibition of phosphatidylinositol hydrolysis by myo-[3H]inositol radioactivity based assay
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1042/cs103s107s
CHEMBL111277 397 1 None -1 4 Rat 10.3 pIC50 = 10.3 Functional
Antagonist activity at ETA receptor in rat MMQ cells assessed as inhibition of phosphatidylinositol hydrolysis by myo-[3H]inositol radioactivity based assayAntagonist activity at ETA receptor in rat MMQ cells assessed as inhibition of phosphatidylinositol hydrolysis by myo-[3H]inositol radioactivity based assay
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1042/cs103s107s
159594 1080 38 None 3 4 Human 10.3 pIC50 = 10.3 Functional
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1042/cs103s107s
3487 1080 38 None 3 4 Human 10.3 pIC50 = 10.3 Functional
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1042/cs103s107s
CHEMBL9194 1080 38 None 3 4 Human 10.3 pIC50 = 10.3 Functional
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1042/cs103s107s
DB06199 1080 38 None 3 4 Human 10.3 pIC50 = 10.3 Functional
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1042/cs103s107s
159594 1080 38 None 3 4 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at ETA receptor (unknown origin) assessed as inhibition of phosphatidylinositol hydrolysis by cell based assayAntagonist activity at ETA receptor (unknown origin) assessed as inhibition of phosphatidylinositol hydrolysis by cell based assay
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1042/cs103s107s
3487 1080 38 None 3 4 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at ETA receptor (unknown origin) assessed as inhibition of phosphatidylinositol hydrolysis by cell based assayAntagonist activity at ETA receptor (unknown origin) assessed as inhibition of phosphatidylinositol hydrolysis by cell based assay
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1042/cs103s107s
CHEMBL9194 1080 38 None 3 4 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at ETA receptor (unknown origin) assessed as inhibition of phosphatidylinositol hydrolysis by cell based assayAntagonist activity at ETA receptor (unknown origin) assessed as inhibition of phosphatidylinositol hydrolysis by cell based assay
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1042/cs103s107s
DB06199 1080 38 None 3 4 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at ETA receptor (unknown origin) assessed as inhibition of phosphatidylinositol hydrolysis by cell based assayAntagonist activity at ETA receptor (unknown origin) assessed as inhibition of phosphatidylinositol hydrolysis by cell based assay
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1042/cs103s107s
14516 397 1 None 1 4 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at human ETA receptor transfected in CHO cell membrane assessed as inhibition of 125I-labelled ET-1 binding to receptor incubated for 3 hrs by competition binding assayAntagonist activity at human ETA receptor transfected in CHO cell membrane assessed as inhibition of 125I-labelled ET-1 binding to receptor incubated for 3 hrs by competition binding assay
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1042/cs103s107s
9916235 397 1 None 1 4 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at human ETA receptor transfected in CHO cell membrane assessed as inhibition of 125I-labelled ET-1 binding to receptor incubated for 3 hrs by competition binding assayAntagonist activity at human ETA receptor transfected in CHO cell membrane assessed as inhibition of 125I-labelled ET-1 binding to receptor incubated for 3 hrs by competition binding assay
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1042/cs103s107s
CHEMBL111277 397 1 None 1 4 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at human ETA receptor transfected in CHO cell membrane assessed as inhibition of 125I-labelled ET-1 binding to receptor incubated for 3 hrs by competition binding assayAntagonist activity at human ETA receptor transfected in CHO cell membrane assessed as inhibition of 125I-labelled ET-1 binding to receptor incubated for 3 hrs by competition binding assay
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1042/cs103s107s
10210629 23076 0 None 2 4 Human 9.9 pIC50 = 9.9 Functional
Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.
ChEMBL 592 15 1 7 5.0 CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
CHEMBL109644 23076 0 None 2 4 Human 9.9 pIC50 = 9.9 Functional
Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.
ChEMBL 592 15 1 7 5.0 CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
168510405 393366 3 None None None Human 9.7 pIC50 = 9.7 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 459 10 1 9 3.5 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCCC(C)C 10.1016/j.ejmech.2023.115681
CHEMBL5632252 393366 3 None None None Human 9.7 pIC50 = 9.7 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 459 10 1 9 3.5 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCCC(C)C 10.1016/j.ejmech.2023.115681
159594 1080 38 None 3 4 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at ETA receptor (unknown origin) assessed as inhibition of arachidonic acid release by cell based assayAntagonist activity at ETA receptor (unknown origin) assessed as inhibition of arachidonic acid release by cell based assay
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1042/cs103s107s
3487 1080 38 None 3 4 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at ETA receptor (unknown origin) assessed as inhibition of arachidonic acid release by cell based assayAntagonist activity at ETA receptor (unknown origin) assessed as inhibition of arachidonic acid release by cell based assay
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1042/cs103s107s
CHEMBL9194 1080 38 None 3 4 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at ETA receptor (unknown origin) assessed as inhibition of arachidonic acid release by cell based assayAntagonist activity at ETA receptor (unknown origin) assessed as inhibition of arachidonic acid release by cell based assay
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1042/cs103s107s
DB06199 1080 38 None 3 4 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at ETA receptor (unknown origin) assessed as inhibition of arachidonic acid release by cell based assayAntagonist activity at ETA receptor (unknown origin) assessed as inhibition of arachidonic acid release by cell based assay
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1042/cs103s107s
168510407 393331 3 None None None Human 9.7 pIC50 = 9.7 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 548 10 1 10 4.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCC1CCCN1C 10.1016/j.ejmech.2023.115681
CHEMBL5631524 393331 3 None None None Human 9.7 pIC50 = 9.7 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 548 10 1 10 4.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCC1CCCN1C 10.1016/j.ejmech.2023.115681
168510406 393343 3 None None None Human 9.6 pIC50 = 9.6 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 471 11 1 9 3.8 CC/C=C/CCOc1nc(-c2ncccn2)nc(NS(C)(=O)=O)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
CHEMBL5631876 393343 3 None None None Human 9.6 pIC50 = 9.6 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 471 11 1 9 3.8 CC/C=C/CCOc1nc(-c2ncccn2)nc(NS(C)(=O)=O)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
9870830 473662 29 None -1 5 Human 9.5 pIC50 = 9.5 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm00008a002
CHEMBL8981 473662 29 None -1 5 Human 9.5 pIC50 = 9.5 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm00008a002
23670447 6168 2 None 4 4 Human 9.5 pIC50 = 9.5 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1021/jm00008a002
9871594 6168 2 None 4 4 Human 9.5 pIC50 = 9.5 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1021/jm00008a002
999 6168 2 None 4 4 Human 9.5 pIC50 = 9.5 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1021/jm00008a002
CHEMBL1204799 6168 2 None 4 4 Human 9.5 pIC50 = 9.5 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1021/jm00008a002
CHEMBL25438 6168 2 None 4 4 Human 9.5 pIC50 = 9.5 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1021/jm00008a002
10187997 219519 0 None 1 4 Human 9.4 pIC50 = 9.4 Functional
Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.
ChEMBL 564 13 1 7 4.2 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
CHEMBL323464 219519 0 None 1 4 Human 9.4 pIC50 = 9.4 Functional
Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.
ChEMBL 564 13 1 7 4.2 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
177639243 393332 0 None None None Human 9.3 pIC50 = 9.3 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 453 9 1 9 2.8 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCC(F)F 10.1016/j.ejmech.2023.115681
CHEMBL5631552 393332 0 None None None Human 9.3 pIC50 = 9.3 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 453 9 1 9 2.8 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCC(F)F 10.1016/j.ejmech.2023.115681
14516 397 1 None 1 4 Human 9.3 pIC50 = 9.3 Functional
Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1021/jm970101g
9916235 397 1 None 1 4 Human 9.3 pIC50 = 9.3 Functional
Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1021/jm970101g
CHEMBL111277 397 1 None 1 4 Human 9.3 pIC50 = 9.3 Functional
Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1021/jm970101g
9915028 23715 19 None -20 3 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human ETA receptor transfected in CHO cell membrane assessed as inhibition of 125I-labelled ET-1 binding to receptor incubated for 3 hrs by competition binding assayAntagonist activity at human ETA receptor transfected in CHO cell membrane assessed as inhibition of 125I-labelled ET-1 binding to receptor incubated for 3 hrs by competition binding assay
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1042/cs103s107s
CHEMBL111612 23715 19 None -20 3 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human ETA receptor transfected in CHO cell membrane assessed as inhibition of 125I-labelled ET-1 binding to receptor incubated for 3 hrs by competition binding assayAntagonist activity at human ETA receptor transfected in CHO cell membrane assessed as inhibition of 125I-labelled ET-1 binding to receptor incubated for 3 hrs by competition binding assay
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1042/cs103s107s
10603409 220129 0 None 1 4 Human 9.3 pIC50 = 9.3 Functional
Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.
ChEMBL 584 13 1 7 4.1 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl 10.1021/jm970101g
CHEMBL325581 220129 0 None 1 4 Human 9.3 pIC50 = 9.3 Functional
Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.
ChEMBL 584 13 1 7 4.1 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl 10.1021/jm970101g
177372766 394391 0 None 2 4 Rat 9.2 pIC50 = 9.2 Functional
Antagonist activity at ETA receptor in endothelin-1 stimulated rat MMQ cells assessed as inhibition of phosphatidylinositol hydrolysis in presence of myo-[3H] inositol by anion exchange chromatographyAntagonist activity at ETA receptor in endothelin-1 stimulated rat MMQ cells assessed as inhibition of phosphatidylinositol hydrolysis in presence of myo-[3H] inositol by anion exchange chromatography
ChEMBL 532 15 1 6 5.9 CCCCN(CCCC)C(=O)CN1[C@H](c2cc(OC)c3c(c2)OCO3)C[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1016/s0014-2999(98)00891-7
CHEMBL5687007 394391 0 None 2 4 Rat 9.2 pIC50 = 9.2 Functional
Antagonist activity at ETA receptor in endothelin-1 stimulated rat MMQ cells assessed as inhibition of phosphatidylinositol hydrolysis in presence of myo-[3H] inositol by anion exchange chromatographyAntagonist activity at ETA receptor in endothelin-1 stimulated rat MMQ cells assessed as inhibition of phosphatidylinositol hydrolysis in presence of myo-[3H] inositol by anion exchange chromatography
ChEMBL 532 15 1 6 5.9 CCCCN(CCCC)C(=O)CN1[C@H](c2cc(OC)c3c(c2)OCO3)C[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1016/s0014-2999(98)00891-7
9915028 23715 19 None 20 3 Rat 9.2 pIC50 = 9.2 Functional
Antagonist activity at ETA receptor in rat MMQ cells assessed as inhibition of phosphatidylinositol hydrolysis by myo-[3H]inositol radioactivity based assayAntagonist activity at ETA receptor in rat MMQ cells assessed as inhibition of phosphatidylinositol hydrolysis by myo-[3H]inositol radioactivity based assay
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1042/cs103s107s
CHEMBL111612 23715 19 None 20 3 Rat 9.2 pIC50 = 9.2 Functional
Antagonist activity at ETA receptor in rat MMQ cells assessed as inhibition of phosphatidylinositol hydrolysis by myo-[3H]inositol radioactivity based assayAntagonist activity at ETA receptor in rat MMQ cells assessed as inhibition of phosphatidylinositol hydrolysis by myo-[3H]inositol radioactivity based assay
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1042/cs103s107s
9915028 23715 19 None -20 3 Human 9.2 pIC50 = 9.2 Functional
Endothelin-1-evoked phosphatidylinositol hydrolysisEndothelin-1-evoked phosphatidylinositol hydrolysis
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.6019/CHEMBL4507258
CHEMBL111612 23715 19 None -20 3 Human 9.2 pIC50 = 9.2 Functional
Endothelin-1-evoked phosphatidylinositol hydrolysisEndothelin-1-evoked phosphatidylinositol hydrolysis
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.6019/CHEMBL4507258
101039204 1466 45 None 1 4 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at ETA receptor in human SKNMC cells assessed as inhibition of endothelin-1-mediated Ca2+ mobilization by fura-2/AM dye-based spectrofluorimetric methodAntagonist activity at ETA receptor in human SKNMC cells assessed as inhibition of endothelin-1-mediated Ca2+ mobilization by fura-2/AM dye-based spectrofluorimetric method
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/j.ejmech.2016.06.006
443289 1466 45 None 1 4 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at ETA receptor in human SKNMC cells assessed as inhibition of endothelin-1-mediated Ca2+ mobilization by fura-2/AM dye-based spectrofluorimetric methodAntagonist activity at ETA receptor in human SKNMC cells assessed as inhibition of endothelin-1-mediated Ca2+ mobilization by fura-2/AM dye-based spectrofluorimetric method
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/j.ejmech.2016.06.006
997 1466 45 None 1 4 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at ETA receptor in human SKNMC cells assessed as inhibition of endothelin-1-mediated Ca2+ mobilization by fura-2/AM dye-based spectrofluorimetric methodAntagonist activity at ETA receptor in human SKNMC cells assessed as inhibition of endothelin-1-mediated Ca2+ mobilization by fura-2/AM dye-based spectrofluorimetric method
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/j.ejmech.2016.06.006
CHEMBL314691 1466 45 None 1 4 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at ETA receptor in human SKNMC cells assessed as inhibition of endothelin-1-mediated Ca2+ mobilization by fura-2/AM dye-based spectrofluorimetric methodAntagonist activity at ETA receptor in human SKNMC cells assessed as inhibition of endothelin-1-mediated Ca2+ mobilization by fura-2/AM dye-based spectrofluorimetric method
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/j.ejmech.2016.06.006
CHEMBL4095638 1466 45 None 1 4 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at ETA receptor in human SKNMC cells assessed as inhibition of endothelin-1-mediated Ca2+ mobilization by fura-2/AM dye-based spectrofluorimetric methodAntagonist activity at ETA receptor in human SKNMC cells assessed as inhibition of endothelin-1-mediated Ca2+ mobilization by fura-2/AM dye-based spectrofluorimetric method
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/j.ejmech.2016.06.006
DB12054 1466 45 None 1 4 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at ETA receptor in human SKNMC cells assessed as inhibition of endothelin-1-mediated Ca2+ mobilization by fura-2/AM dye-based spectrofluorimetric methodAntagonist activity at ETA receptor in human SKNMC cells assessed as inhibition of endothelin-1-mediated Ca2+ mobilization by fura-2/AM dye-based spectrofluorimetric method
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/j.ejmech.2016.06.006
CHEMBL3980643 487817 0 None -6 2 Human 9.2 pIC50 = 9.2 Functional
Agonist activity at ETA receptor in human SKNMC cells assessed as induction of Ca2+ mobilization by fluorimetric methodAgonist activity at ETA receptor in human SKNMC cells assessed as induction of Ca2+ mobilization by fluorimetric method
ChEMBL 2489 47 32 36 -5.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)[C@@H](C)CC 10.1016/j.ejmech.2016.06.006
177638412 393380 0 None None None Human 9.1 pIC50 = 9.1 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 571 10 1 9 5.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC(F)F 10.1016/j.ejmech.2023.115681
CHEMBL5632489 393380 0 None None None Human 9.1 pIC50 = 9.1 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 571 10 1 9 5.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC(F)F 10.1016/j.ejmech.2023.115681
177638629 393458 0 None None None Human 9.1 pIC50 = 9.1 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 515 10 1 9 4.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCC(F)F 10.1016/j.ejmech.2023.115681
CHEMBL5633840 393458 0 None None None Human 9.1 pIC50 = 9.1 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 515 10 1 9 4.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCC(F)F 10.1016/j.ejmech.2023.115681
177638891 393389 0 None None None Human 9.0 pIC50 = 9.0 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 533 12 1 9 5.3 CC/C=C/CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccccc2)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
CHEMBL5632583 393389 0 None None None Human 9.0 pIC50 = 9.0 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 533 12 1 9 5.3 CC/C=C/CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccccc2)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
177638411 393379 0 None None None Human 9.0 pIC50 = 9.0 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 575 10 1 9 6.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC1CCC1 10.1016/j.ejmech.2023.115681
CHEMBL5632488 393379 0 None None None Human 9.0 pIC50 = 9.0 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 575 10 1 9 6.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC1CCC1 10.1016/j.ejmech.2023.115681
10230737 221806 0 None 16 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL329251 221806 0 None 16 2 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3F)c3ccccc32)n1 10.1021/jm031115r
177639724 393338 0 None None None Human 8.9 pIC50 = 8.9 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 576 10 1 10 4.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cc2)nc(-c2ncccn2)nc1OCC1CCCCN1C 10.1016/j.ejmech.2023.115681
CHEMBL5631693 393338 0 None None None Human 8.9 pIC50 = 8.9 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 576 10 1 10 4.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cc2)nc(-c2ncccn2)nc1OCC1CCCCN1C 10.1016/j.ejmech.2023.115681
177638595 393362 0 None None None Human 8.9 pIC50 = 8.9 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 589 10 1 9 6.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC1CCCC1 10.1016/j.ejmech.2023.115681
CHEMBL5632210 393362 0 None None None Human 8.9 pIC50 = 8.9 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 589 10 1 9 6.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC1CCCC1 10.1016/j.ejmech.2023.115681
177639063 393325 0 None None None Human 8.9 pIC50 = 8.9 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 519 10 1 9 4.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cc2)nc(-c2ncccn2)nc1OCC1CC1 10.1016/j.ejmech.2023.115681
CHEMBL5631430 393325 0 None None None Human 8.9 pIC50 = 8.9 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 519 10 1 9 4.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cc2)nc(-c2ncccn2)nc1OCC1CC1 10.1016/j.ejmech.2023.115681
177638831 393394 0 None None None Human 8.9 pIC50 = 8.9 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 561 10 1 9 5.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC1CC1 10.1016/j.ejmech.2023.115681
CHEMBL5632683 393394 0 None None None Human 8.9 pIC50 = 8.9 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 561 10 1 9 5.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC1CC1 10.1016/j.ejmech.2023.115681
139831677 393335 0 None None None Human 8.9 pIC50 = 8.9 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 561 11 1 9 5.8 C=CCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
CHEMBL5631563 393335 0 None None None Human 8.9 pIC50 = 8.9 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 561 11 1 9 5.8 C=CCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
177638795 393365 0 None None None Human 8.9 pIC50 = 8.9 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 535 11 1 9 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cc2)nc(-c2ncccn2)nc1OCCC(C)C 10.1016/j.ejmech.2023.115681
CHEMBL5632230 393365 0 None None None Human 8.9 pIC50 = 8.9 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 535 11 1 9 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cc2)nc(-c2ncccn2)nc1OCCC(C)C 10.1016/j.ejmech.2023.115681
11318978 332657 0 None 7 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 560 7 2 6 4.8 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)n1 10.1021/jm031115r
CHEMBL431286 332657 0 None 7 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 560 7 2 6 4.8 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)n1 10.1021/jm031115r
177638955 393403 0 None None None Human 8.9 pIC50 = 8.9 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 618 10 1 10 5.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC1CCCN(C)C1 10.1016/j.ejmech.2023.115681
CHEMBL5632884 393403 0 None None None Human 8.9 pIC50 = 8.9 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 618 10 1 10 5.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC1CCCN(C)C1 10.1016/j.ejmech.2023.115681
177639005 393377 0 None None None Human 8.8 pIC50 = 8.8 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 604 10 1 10 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC1CCCN1C 10.1016/j.ejmech.2023.115681
CHEMBL5632434 393377 0 None None None Human 8.8 pIC50 = 8.8 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 604 10 1 10 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC1CCCN1C 10.1016/j.ejmech.2023.115681
177638642 393460 0 None None None Human 8.8 pIC50 = 8.8 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 547 10 1 9 5.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cc2)nc(-c2ncccn2)nc1OCC1CCCC1 10.1016/j.ejmech.2023.115681
CHEMBL5633865 393460 0 None None None Human 8.8 pIC50 = 8.8 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 547 10 1 9 5.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cc2)nc(-c2ncccn2)nc1OCC1CCCC1 10.1016/j.ejmech.2023.115681
10651488 328358 0 None 1 4 Human 8.8 pIC50 = 8.8 Functional
Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.
ChEMBL 618 13 1 7 4.8 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F 10.1021/jm970101g
CHEMBL419367 328358 0 None 1 4 Human 8.8 pIC50 = 8.8 Functional
Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.Ability to block the ET-1-induced hydrolysis of inositol phosphate in Endothelin A receptor of MMQ cells.
ChEMBL 618 13 1 7 4.8 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F 10.1021/jm970101g
177639525 393433 0 None None None Human 8.8 pIC50 = 8.8 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 457 9 1 9 3.3 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCC1CCC1 10.1016/j.ejmech.2023.115681
CHEMBL5633448 393433 0 None None None Human 8.8 pIC50 = 8.8 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 457 9 1 9 3.3 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCC1CCC1 10.1016/j.ejmech.2023.115681
CHEMBL412706 488244 0 None None None Pig 8.8 pIC50 = 8.8 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 950 23 10 9 2.1 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
177639681 393449 0 None None None Human 8.8 pIC50 = 8.8 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 521 11 1 9 5.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCCC(C)C 10.1016/j.ejmech.2023.115681
CHEMBL5633675 393449 0 None None None Human 8.8 pIC50 = 8.8 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 521 11 1 9 5.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCCC(C)C 10.1016/j.ejmech.2023.115681
9894443 222053 0 None 3 2 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 7 2 6 5.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)n1 10.1021/jm031115r
CHEMBL330104 222053 0 None 3 2 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 7 2 6 5.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)n1 10.1021/jm031115r
9955200 23637 0 None 53 3 Human 8.7 pIC50 = 8.7 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 446 6 1 7 3.8 COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL11115 23637 0 None 53 3 Human 8.7 pIC50 = 8.7 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 446 6 1 7 3.8 COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
177638807 393387 0 None None None Human 8.7 pIC50 = 8.7 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 519 10 1 9 4.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCC1CCC1 10.1016/j.ejmech.2023.115681
CHEMBL5632569 393387 0 None None None Human 8.7 pIC50 = 8.7 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 519 10 1 9 4.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCC1CCC1 10.1016/j.ejmech.2023.115681
177638854 393398 0 None None None Human 8.7 pIC50 = 8.7 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 562 10 1 10 4.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCC1CCCCN1C 10.1016/j.ejmech.2023.115681
CHEMBL5632750 393398 0 None None None Human 8.7 pIC50 = 8.7 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 562 10 1 10 4.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCC1CCCCN1C 10.1016/j.ejmech.2023.115681
70690542 157879 0 None 1 2 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 532 9 1 6 6.6 CCCCc1nc2ccc(F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058375 157879 0 None 1 2 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 532 9 1 6 6.6 CCCCc1nc2ccc(F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
70696781 157880 0 None 1 2 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 582 9 1 6 7.5 CCCCc1nc2ccc(C(F)(F)F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058376 157880 0 None 1 2 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 582 9 1 6 7.5 CCCCc1nc2ccc(C(F)(F)F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
11342089 216847 0 None 9 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 568 9 2 8 4.0 COc1ccc(CN2C(=O)CN[C@](c3cccc(OC)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL316629 216847 0 None 9 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 568 9 2 8 4.0 COc1ccc(CN2C(=O)CN[C@](c3cccc(OC)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
10230703 474724 0 None 4 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 542 7 2 6 4.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3Cl)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96472 474724 0 None 4 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 542 7 2 6 4.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3Cl)c3ccccc32)n1 10.1021/jm031115r
9957883 198910 0 None 25 2 Human 7.0 pIC50 = 7 Functional
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 507 7 1 9 5.0 COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00232-6
CHEMBL27732 198910 0 None 25 2 Human 7.0 pIC50 = 7 Functional
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 507 7 1 9 5.0 COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00232-6
44213651 18647 0 None None None Human 5.0 pIC50 = 5 Functional
Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.
ChEMBL 343 3 1 4 4.2 OCC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL100795 18647 0 None None None Human 5.0 pIC50 = 5 Functional
Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.
ChEMBL 343 3 1 4 4.2 OCC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
11455999 474698 0 None 31 2 Human 7.0 pIC50 = 7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 580 7 2 4 6.6 O=C(O)[C@@H](Oc1cccc(Cl)c1)[C@@]1(c2ccccc2)NCC(=O)N(Cc2c(Cl)cccc2Cl)c2ccccc21 10.1021/jm031115r
CHEMBL96325 474698 0 None 31 2 Human 7.0 pIC50 = 7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 580 7 2 4 6.6 O=C(O)[C@@H](Oc1cccc(Cl)c1)[C@@]1(c2ccccc2)NCC(=O)N(Cc2c(Cl)cccc2Cl)c2ccccc21 10.1021/jm031115r
11490160 474390 0 None 5 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 584 8 2 6 5.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(-c4ccccc4)cc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL94446 474390 0 None 5 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 584 8 2 6 5.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(-c4ccccc4)cc3)c3ccccc32)n1 10.1021/jm031115r
11273181 474731 0 None -4 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 7 2 6 5.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3C(F)(F)F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96506 474731 0 None -4 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 7 2 6 5.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3C(F)(F)F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL386778 487700 0 None None None Pig 8.0 pIC50 = 8.0 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 965 24 10 9 3.1 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
CHEMBL405337 487859 0 None None None Pig 8.0 pIC50 = 8.0 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 951 23 10 9 2.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
CHEMBL405916 487887 0 None None None Pig 8.0 pIC50 = 8.0 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 999 23 10 9 4.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
CHEMBL409180 488050 0 None None None Pig 8.0 pIC50 = 8.0 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 1022 23 10 8 4.9 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
6450144 241134 4 None None None Rat 8.0 pIC50 = 8.0 Functional
Antagonist activity at endothelin A receptor in rat A7r5 cells assessed as inhibition of ET-1-induced increase in cytosolic free Ca2+ level treated 1 min prior to ET-1 addition by fura-2 dye-based spectrofluorometric analysisAntagonist activity at endothelin A receptor in rat A7r5 cells assessed as inhibition of ET-1-induced increase in cytosolic free Ca2+ level treated 1 min prior to ET-1 addition by fura-2 dye-based spectrofluorometric analysis
ChEMBL 632 5 3 6 8.1 CC1(C)CC[C@]2(C(=O)O)CC[C@]3(COC(=O)/C=C/c4ccc(O)c(O)c4)C(=CC[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1 10.1016/j.bmc.2015.06.055
CHEMBL3601500 241134 4 None None None Rat 8.0 pIC50 = 8.0 Functional
Antagonist activity at endothelin A receptor in rat A7r5 cells assessed as inhibition of ET-1-induced increase in cytosolic free Ca2+ level treated 1 min prior to ET-1 addition by fura-2 dye-based spectrofluorometric analysisAntagonist activity at endothelin A receptor in rat A7r5 cells assessed as inhibition of ET-1-induced increase in cytosolic free Ca2+ level treated 1 min prior to ET-1 addition by fura-2 dye-based spectrofluorometric analysis
ChEMBL 632 5 3 6 8.1 CC1(C)CC[C@]2(C(=O)O)CC[C@]3(COC(=O)/C=C/c4ccc(O)c(O)c4)C(=CC[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1 10.1016/j.bmc.2015.06.055
70684240 157881 0 None 1 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 559 10 1 8 6.4 CCCCc1nc2ccc([N+](=O)[O-])cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058377 157881 0 None 1 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 559 10 1 8 6.4 CCCCc1nc2ccc([N+](=O)[O-])cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
11421972 474714 0 None 2 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 592 8 2 7 4.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(OC(F)(F)F)c3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96422 474714 0 None 2 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 592 8 2 7 4.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(OC(F)(F)F)c3)c3ccccc32)n1 10.1021/jm031115r
11342005 474435 0 None 2 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 562 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)c(F)c(F)c3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL94766 474435 0 None 2 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 562 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)c(F)c(F)c3)c3ccccc32)n1 10.1021/jm031115r
11744509 19765 0 None 5 2 Human 7.0 pIC50 = 7.0 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 450 5 1 6 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)cc2)cc1 10.1021/jm00008a002
CHEMBL10733 19765 0 None 5 2 Human 7.0 pIC50 = 7.0 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 450 5 1 6 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)cc2)cc1 10.1021/jm00008a002
122194935 252139 0 None None None Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition of ET-1-induced Ca2+ efflux from endoplasmic reticulum into cytosol by fluo-4 dye-based FLIPR assayAntagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition of ET-1-induced Ca2+ efflux from endoplasmic reticulum into cytosol by fluo-4 dye-based FLIPR assay
ChEMBL 619 11 2 8 6.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(S(F)(F)(F)(F)F)cc2)cc(-c2ncccn2)cc1OCCO 10.1021/acs.jmedchem.5b00258
CHEMBL3633040 252139 0 None None None Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition of ET-1-induced Ca2+ efflux from endoplasmic reticulum into cytosol by fluo-4 dye-based FLIPR assayAntagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition of ET-1-induced Ca2+ efflux from endoplasmic reticulum into cytosol by fluo-4 dye-based FLIPR assay
ChEMBL 619 11 2 8 6.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(S(F)(F)(F)(F)F)cc2)cc(-c2ncccn2)cc1OCCO 10.1021/acs.jmedchem.5b00258
11387205 221058 0 None -1 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 8 2 7 4.5 COc1ccc(CN2C(=O)CN[C@](C3CCCCC3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL328073 221058 0 None -1 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 8 2 7 4.5 COc1ccc(CN2C(=O)CN[C@](C3CCCCC3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL62302 489347 0 None None None Pig 7.9 pIC50 = 7.9 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 935 22 9 8 3.9 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
10342643 19496 0 None 144 2 Human 7.9 pIC50 = 7.9 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1C 10.1021/jm00008a002
CHEMBL10588 19496 0 None 144 2 Human 7.9 pIC50 = 7.9 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1C 10.1021/jm00008a002
10342643 19496 0 None 144 2 Human 7.9 pIC50 = 7.9 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1C 10.1021/jm00008a002
CHEMBL10588 19496 0 None 144 2 Human 7.9 pIC50 = 7.9 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1C 10.1021/jm00008a002
10224745 222167 0 None 15 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 432 5 2 6 2.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 10.1021/jm031115r
CHEMBL330425 222167 0 None 15 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 432 5 2 6 2.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 10.1021/jm031115r
9865706 198427 0 None 1 2 Human 5.9 pIC50 = 5.9 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 400 4 1 5 4.1 Cc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm00008a002
CHEMBL273613 198427 0 None 1 2 Human 5.9 pIC50 = 5.9 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 400 4 1 5 4.1 Cc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm00008a002
10452089 18910 0 None None None Human 4.9 pIC50 = 4.9 Functional
Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.
ChEMBL 375 3 0 5 4.1 COC(=O)C(c1ccc2c(c1)OCO2)c1c2c(nc3ccccc13)CCCC2 10.1016/S0960-894X(96)00551-3
CHEMBL102494 18910 0 None None None Human 4.9 pIC50 = 4.9 Functional
Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.
ChEMBL 375 3 0 5 4.1 COC(=O)C(c1ccc2c(c1)OCO2)c1c2c(nc3ccccc13)CCCC2 10.1016/S0960-894X(96)00551-3
11432855 474721 0 None 28 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 552 8 3 7 3.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(=O)O)cc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96463 474721 0 None 28 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 552 8 3 7 3.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(=O)O)cc3)c3ccccc32)n1 10.1021/jm031115r
11318559 474672 0 None 5 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 531 8 2 8 2.1 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCN3CCOCC3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96193 474672 0 None 5 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 531 8 2 8 2.1 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCN3CCOCC3)c3ccccc32)n1 10.1021/jm031115r
11238540 474413 0 None 11 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 8 2 5 5.9 COc1cccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
CHEMBL94602 474413 0 None 11 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 8 2 5 5.9 COc1cccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
10140418 215880 0 None 43 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 476 7 3 7 1.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC(=O)O)c3ccccc32)n1 10.1021/jm031115r
CHEMBL313867 215880 0 None 43 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 476 7 3 7 1.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC(=O)O)c3ccccc32)n1 10.1021/jm031115r
11308052 222141 0 None 2 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 618 10 2 6 5.8 CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)c1 10.1021/jm031115r
CHEMBL330354 222141 0 None 2 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 618 10 2 6 5.8 CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)c1 10.1021/jm031115r
122194934 252138 0 None None None Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition of ET-1-induced Ca2+ efflux from endoplasmic reticulum into cytosol by fluo-4 dye-based FLIPR assayAntagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition of ET-1-induced Ca2+ efflux from endoplasmic reticulum into cytosol by fluo-4 dye-based FLIPR assay
ChEMBL 561 10 2 8 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(F)(F)F)cc2)cc(-c2ncccn2)cc1OCCO 10.1021/acs.jmedchem.5b00258
CHEMBL3633039 252138 0 None None None Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition of ET-1-induced Ca2+ efflux from endoplasmic reticulum into cytosol by fluo-4 dye-based FLIPR assayAntagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition of ET-1-induced Ca2+ efflux from endoplasmic reticulum into cytosol by fluo-4 dye-based FLIPR assay
ChEMBL 561 10 2 8 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(F)(F)F)cc2)cc(-c2ncccn2)cc1OCCO 10.1021/acs.jmedchem.5b00258
CHEMBL97470 489426 0 None -1 2 Human 6.9 pIC50 = 6.9 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 939 26 10 9 3.0 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL3143473 486740 0 None -1071 2 Human 5.9 pIC50 = 5.9 Functional
Antagonistic activity against endothelin A (ETA) receptor using human neuroblastoma cell line.Antagonistic activity against endothelin A (ETA) receptor using human neuroblastoma cell line.
ChEMBL 627 14 4 6 4.8 CCCC[C@@H](NC(=O)[C@@H](Cc1cn(COC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00084-7
CHEMBL3305972 486740 0 None -1071 2 Human 5.9 pIC50 = 5.9 Functional
Antagonistic activity against endothelin A (ETA) receptor using human neuroblastoma cell line.Antagonistic activity against endothelin A (ETA) receptor using human neuroblastoma cell line.
ChEMBL 627 14 4 6 4.8 CCCC[C@@H](NC(=O)[C@@H](Cc1cn(COC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00084-7
345351 23663 3 None 24 3 Human 5.9 pIC50 = 5.9 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 386 4 1 5 3.8 O=C1OC(O)(c2ccccc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
CHEMBL11131 23663 3 None 24 3 Human 5.9 pIC50 = 5.9 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 386 4 1 5 3.8 O=C1OC(O)(c2ccccc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
44332623 19106 0 None None None Human 4.9 pIC50 = 4.9 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 320 3 1 4 2.9 Cc1cc(C(C(N)=O)c2ccc3c(c2)OCO3)c2ccccc2n1 10.1016/S0960-894X(96)00551-3
CHEMBL103886 19106 0 None None None Human 4.9 pIC50 = 4.9 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 320 3 1 4 2.9 Cc1cc(C(C(N)=O)c2ccc3c(c2)OCO3)c2ccccc2n1 10.1016/S0960-894X(96)00551-3
CHEMBL405599 487870 0 None 1 3 Human 7.9 pIC50 = 7.9 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 966 27 12 9 2.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
11744509 19765 0 None 5 2 Human 6.9 pIC50 = 6.9 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 450 5 1 6 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)cc2)cc1 10.1021/jm00008a002
CHEMBL10733 19765 0 None 5 2 Human 6.9 pIC50 = 6.9 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 450 5 1 6 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)cc2)cc1 10.1021/jm00008a002
11386977 474433 0 None 1 2 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 528 8 2 6 4.8 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCC3CCCCC3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL94752 474433 0 None 1 2 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 528 8 2 6 4.8 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCC3CCCCC3)c3ccccc32)n1 10.1021/jm031115r
11226767 474414 0 None 6 2 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 560 7 2 4 6.2 Cc1ccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL94606 474414 0 None 6 2 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 560 7 2 4 6.2 Cc1ccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)cc1 10.1021/jm031115r
11452452 474112 0 None None None Human 5.8 pIC50 = 5.8 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 404 5 2 6 1.8 CN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2ncccn2)C(=O)O)c2ccccc21 10.1021/jm031115r
CHEMBL92612 474112 0 None None None Human 5.8 pIC50 = 5.8 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 404 5 2 6 1.8 CN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2ncccn2)C(=O)O)c2ccccc21 10.1021/jm031115r
CHEMBL284250 484245 0 None -19 4 Human 7.8 pIC50 = 7.8 Functional
Functional inhibition of ET-1 induced [Ca2+] increase in human neuroblastoma-derived SK-N-MC cells, which express Endothelin A receptorFunctional inhibition of ET-1 induced [Ca2+] increase in human neuroblastoma-derived SK-N-MC cells, which express Endothelin A receptor
ChEMBL 631 12 5 4 4.5 CCCC[C@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1016/0960-894X(95)00237-N
11331242 217041 0 None 1 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 652 8 2 6 7.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3cccc(-c4ccccc4)c3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)n1 10.1021/jm031115r
CHEMBL318086 217041 0 None 1 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 652 8 2 6 7.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3cccc(-c4ccccc4)c3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)n1 10.1021/jm031115r
CHEMBL265116 486147 0 None -3 3 Human 6.8 pIC50 = 6.8 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 957 25 9 8 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
CHEMBL4533479 477450 1 None -1 2 Human 5.8 pIC50 = 5.8 Functional
Eurofins cellular functional assay - Antagonist (EDNRA)Eurofins cellular functional assay - Antagonist (EDNRA)
ChEMBL 558 11 2 6 5.8 CCCOc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(CC)cccc2CC)cc1 10.6019/CHEMBL4507261
10166981 474012 0 None 2 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 7 2 6 5.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(F)(F)F)cc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL91926 474012 0 None 2 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 7 2 6 5.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(F)(F)F)cc3)c3ccccc32)n1 10.1021/jm031115r
11410074 474661 0 None 1 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 536 9 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCCc3ccccc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96114 474661 0 None 1 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 536 9 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCCc3ccccc3)c3ccccc32)n1 10.1021/jm031115r
11365059 474666 0 None 1 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 564 7 2 6 5.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(C)(C)C)cc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96154 474666 0 None 1 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 564 7 2 6 5.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(C(C)(C)C)cc3)c3ccccc32)n1 10.1021/jm031115r
10347783 474703 0 None 32 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 560 7 2 4 5.6 Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)c1 10.1021/jm031115r
CHEMBL96347 474703 0 None 32 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 560 7 2 4 5.6 Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)c1 10.1021/jm031115r
11753090 215882 0 None 7 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 542 7 2 6 4.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(Cl)cc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL313870 215882 0 None 7 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 542 7 2 6 4.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(Cl)cc3)c3ccccc32)n1 10.1021/jm031115r
10412464 23442 0 None 11 2 Human 6.8 pIC50 = 6.8 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 470 6 1 5 5.4 COc1ccc(CC2=C(c3ccc(Cl)c(Cl)c3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL10996 23442 0 None 11 2 Human 6.8 pIC50 = 6.8 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 470 6 1 5 5.4 COc1ccc(CC2=C(c3ccc(Cl)c(Cl)c3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
44327656 278985 0 None -1 2 Human 5.8 pIC50 = 5.8 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 977 25 9 8 4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(F)(F)F)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL386181 278985 0 None -1 2 Human 5.8 pIC50 = 5.8 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 977 25 9 8 4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(F)(F)F)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
11330923 474691 0 None -1 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 606 10 2 6 6.3 CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(C)cc(C)cc3C)c3ccccc32)c1 10.1021/jm031115r
CHEMBL96303 474691 0 None -1 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 606 10 2 6 6.3 CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(C)cc(C)cc3C)c3ccccc32)c1 10.1021/jm031115r
11226740 474766 0 None 9 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 558 7 2 4 6.0 Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
CHEMBL96704 474766 0 None 9 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 558 7 2 4 6.0 Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
CHEMBL408574 488022 0 None None None Pig 7.7 pIC50 = 7.7 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 893 21 9 8 2.9 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
10410546 23716 0 None 37 2 Human 6.7 pIC50 = 6.7 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 432 7 1 6 4.1 COc1ccc(CC2=C(c3ccc(OC)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL11162 23716 0 None 37 2 Human 6.7 pIC50 = 6.7 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 432 7 1 6 4.1 COc1ccc(CC2=C(c3ccc(OC)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL319537 486628 0 None 2 2 Human 5.7 pIC50 = 5.7 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 881 24 9 8 4.0 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL409808 488084 0 None None None Pig 8.7 pIC50 = 8.7 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 964 24 10 9 2.5 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
177639505 393329 0 None None None Human 8.7 pIC50 = 8.7 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 500 9 1 10 2.8 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCC1CCCN(C)C1 10.1016/j.ejmech.2023.115681
CHEMBL5631474 393329 0 None None None Human 8.7 pIC50 = 8.7 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 500 9 1 10 2.8 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCC1CCCN(C)C1 10.1016/j.ejmech.2023.115681
177638812 393388 0 None None None Human 8.7 pIC50 = 8.7 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 441 8 1 9 2.5 CC#CCOc1nc(-c2ncccn2)nc(NS(C)(=O)=O)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
CHEMBL5632575 393388 0 None None None Human 8.7 pIC50 = 8.7 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 441 8 1 9 2.5 CC#CCOc1nc(-c2ncccn2)nc(NS(C)(=O)=O)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
177639031 393409 0 None None None Human 8.7 pIC50 = 8.7 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 471 9 1 9 3.7 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCC1CCCC1 10.1016/j.ejmech.2023.115681
CHEMBL5632929 393409 0 None None None Human 8.7 pIC50 = 8.7 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 471 9 1 9 3.7 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCC1CCCC1 10.1016/j.ejmech.2023.115681
177639078 393407 0 None None None Human 8.7 pIC50 = 8.7 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 500 9 1 10 3.0 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCC1CCCCN1C 10.1016/j.ejmech.2023.115681
CHEMBL5632916 393407 0 None None None Human 8.7 pIC50 = 8.7 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 500 9 1 10 3.0 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCC1CCCCN1C 10.1016/j.ejmech.2023.115681
177638883 393376 0 None None None Human 8.6 pIC50 = 8.6 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 486 9 1 10 2.6 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCC1CCCN1C 10.1016/j.ejmech.2023.115681
CHEMBL5632409 393376 0 None None None Human 8.6 pIC50 = 8.6 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 486 9 1 10 2.6 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCC1CCCN1C 10.1016/j.ejmech.2023.115681
177639745 393341 0 None None None Human 8.6 pIC50 = 8.6 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 443 9 1 9 2.9 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCC1CC1 10.1016/j.ejmech.2023.115681
CHEMBL5631743 393341 0 None None None Human 8.6 pIC50 = 8.6 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 443 9 1 9 2.9 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCC1CC1 10.1016/j.ejmech.2023.115681
10120430 474409 0 None 5 2 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 562 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)ccc(F)c3F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL94580 474409 0 None 5 2 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 562 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)ccc(F)c3F)c3ccccc32)n1 10.1021/jm031115r
9890440 22570 0 None 301 2 Human 8.6 pIC50 = 8.6 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 460 6 1 7 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(C)c2)cc1 10.1021/jm00008a002
CHEMBL10924 22570 0 None 301 2 Human 8.6 pIC50 = 8.6 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 460 6 1 7 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(C)c2)cc1 10.1021/jm00008a002
177638478 393352 0 None None None Human 8.6 pIC50 = 8.6 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 443 10 1 9 3.1 C=CCCOc1nc(-c2ncccn2)nc(NS(C)(=O)=O)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
CHEMBL5632030 393352 0 None None None Human 8.6 pIC50 = 8.6 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 443 10 1 9 3.1 C=CCCOc1nc(-c2ncccn2)nc(NS(C)(=O)=O)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
177638505 393382 0 None None None Human 8.6 pIC50 = 8.6 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 505 10 1 9 4.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCC1CC1 10.1016/j.ejmech.2023.115681
CHEMBL5632499 393382 0 None None None Human 8.6 pIC50 = 8.6 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 505 10 1 9 4.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCC1CC1 10.1016/j.ejmech.2023.115681
177643617 393237 0 None None None Human 8.6 pIC50 = 8.6 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 576 10 1 10 4.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cc2)nc(-c2ncccn2)nc1OCC1CCCN(C)C1 10.1016/j.ejmech.2023.115681
CHEMBL5629915 393237 0 None None None Human 8.6 pIC50 = 8.6 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 576 10 1 10 4.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cc2)nc(-c2ncccn2)nc1OCC1CCCN(C)C1 10.1016/j.ejmech.2023.115681
10166543 221848 0 None 33 2 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 562 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL329477 221848 0 None 33 2 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 562 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)n1 10.1021/jm031115r
10282008 474005 0 None 12 2 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 592 8 2 7 4.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(OC(F)(F)F)cc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL91873 474005 0 None 12 2 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 592 8 2 7 4.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(OC(F)(F)F)cc3)c3ccccc32)n1 10.1021/jm031115r
177638539 393456 0 None None None Human 8.6 pIC50 = 8.6 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 618 10 1 10 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC1CCCCN1C 10.1016/j.ejmech.2023.115681
CHEMBL5633806 393456 0 None None None Human 8.6 pIC50 = 8.6 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 618 10 1 10 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC1CCCCN1C 10.1016/j.ejmech.2023.115681
177638784 393358 0 None None None Human 8.6 pIC50 = 8.6 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 533 10 1 9 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCC1CCCC1 10.1016/j.ejmech.2023.115681
CHEMBL5632121 393358 0 None None None Human 8.6 pIC50 = 8.6 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 533 10 1 9 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCC1CCCC1 10.1016/j.ejmech.2023.115681
177638465 393321 0 None None None Human 8.5 pIC50 = 8.5 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 517 9 1 9 4.2 CC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C)cc2)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
CHEMBL5631372 393321 0 None None None Human 8.5 pIC50 = 8.5 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 517 9 1 9 4.2 CC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C)cc2)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
11224973 217073 0 None 32 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 460 7 2 6 2.9 CCc1cc(CC)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 10.1021/jm031115r
CHEMBL318270 217073 0 None 32 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 460 7 2 6 2.9 CCc1cc(CC)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 10.1021/jm031115r
11169125 474445 0 None 5 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 574 7 2 4 6.5 Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
CHEMBL94802 474445 0 None 5 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 574 7 2 4 6.5 Cc1cc(C)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
CHEMBL263295 486079 0 None -1 2 Human 6.7 pIC50 = 6.7 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 964 25 9 8 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
10024044 22156 0 None None None Human 5.7 pIC50 = 5.7 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 402 6 1 5 4.1 COc1ccc(CC2=C(c3ccccc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL10897 22156 0 None None None Human 5.7 pIC50 = 5.7 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 402 6 1 5 4.1 COc1ccc(CC2=C(c3ccccc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
44332577 19046 0 None None None Human 4.7 pIC50 = 4.7 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 341 3 0 4 4.4 O=CC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL103484 19046 0 None None None Human 4.7 pIC50 = 4.7 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 341 3 0 4 4.4 O=CC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL2373086 485960 0 None None None Pig 7.7 pIC50 = 7.7 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 949 23 9 8 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)[C@@H](C)CC)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
197712 807 76 None 85 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1021/jm031115r
3951 807 76 None 85 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1021/jm031115r
4337 807 76 None 85 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1021/jm031115r
6918493 807 76 None 85 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1021/jm031115r
CHEMBL1111 807 76 None 85 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1021/jm031115r
CHEMBL302753 807 76 None 85 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1021/jm031115r
DB06403 807 76 None 85 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1021/jm031115r
CHEMBL317099 486608 0 None -69 2 Human 5.7 pIC50 = 5.7 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 881 24 9 8 2.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL96822 489422 0 None -1 2 Human 5.7 pIC50 = 5.7 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 959 26 9 9 3.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NS(C)(=O)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
11786120 333779 0 None 17 2 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 546 7 2 4 5.9 O=C(O)[C@@H](Oc1ccccc1)[C@@]1(c2ccccc2)NCC(=O)N(Cc2c(Cl)cccc2Cl)c2ccccc21 10.1021/jm031115r
CHEMBL440507 333779 0 None 17 2 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 546 7 2 4 5.9 O=C(O)[C@@H](Oc1ccccc1)[C@@]1(c2ccccc2)NCC(=O)N(Cc2c(Cl)cccc2Cl)c2ccccc21 10.1021/jm031115r
70692693 157873 0 None -1 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 500 8 1 6 6.1 CCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058369 157873 0 None -1 2 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 500 8 1 6 6.1 CCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
10385531 222159 0 None None None Human 5.7 pIC50 = 5.7 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 387 4 0 6 4.4 COC(=O)C(Oc1c2ccccc2nc2ccccc12)c1ccc2c(c1)OCO2 10.1016/S0960-894X(96)00551-3
CHEMBL330414 222159 0 None None None Human 5.7 pIC50 = 5.7 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 387 4 0 6 4.4 COC(=O)C(Oc1c2ccccc2nc2ccccc12)c1ccc2c(c1)OCO2 10.1016/S0960-894X(96)00551-3
10024044 22156 0 None None None Human 5.7 pIC50 = 5.7 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 402 6 1 5 4.1 COc1ccc(CC2=C(c3ccccc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL10897 22156 0 None None None Human 5.7 pIC50 = 5.7 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 402 6 1 5 4.1 COc1ccc(CC2=C(c3ccccc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
10070783 197378 0 None 3 3 Human 5.7 pIC50 = 5.7 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 420 4 1 5 4.5 O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
CHEMBL267094 197378 0 None 3 3 Human 5.7 pIC50 = 5.7 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 420 4 1 5 4.5 O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
11387315 474326 0 None -1 2 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 552 8 2 7 4.3 COc1ccc(CN2C(=O)CN[C@](c3ccc(C)cc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL94091 474326 0 None -1 2 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 552 8 2 7 4.3 COc1ccc(CN2C(=O)CN[C@](c3ccc(C)cc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
11408654 474798 0 None 19 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 464 7 2 8 1.8 COc1cc(OC)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96906 474798 0 None 19 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 464 7 2 8 1.8 COc1cc(OC)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 10.1021/jm031115r
11409474 474446 0 None 1 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 502 10 2 6 4.4 CCCCCCN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2nc(C)cc(C)n2)C(=O)O)c2ccccc21 10.1021/jm031115r
CHEMBL94810 474446 0 None 1 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 502 10 2 6 4.4 CCCCCCN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2nc(C)cc(C)n2)C(=O)O)c2ccccc21 10.1021/jm031115r
44327659 219379 0 None -1 2 Human 6.6 pIC50 = 6.6 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 8 4.6 CCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)C(c1ccccc1)c1ccccc1 10.1021/jm00015a003
CHEMBL323331 219379 0 None -1 2 Human 6.6 pIC50 = 6.6 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 8 4.6 CCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)C(c1ccccc1)c1ccccc1 10.1021/jm00015a003
CHEMBL263186 486076 0 None None None Pig 7.6 pIC50 = 7.6 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 983 23 9 8 4.5 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
9896251 199018 0 None -1 3 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at endothelin receptor subtype AAntagonist activity at endothelin receptor subtype A
ChEMBL 682 12 1 9 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/j.bmc.2012.06.011
CHEMBL278176 199018 0 None -1 3 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at endothelin receptor subtype AAntagonist activity at endothelin receptor subtype A
ChEMBL 682 12 1 9 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/j.bmc.2012.06.011
11467573 216876 0 None 9 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 606 8 2 7 5.0 COc1ccc(CN2C(=O)CN[C@](c3cccc(C(F)(F)F)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL316851 216876 0 None 9 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 606 8 2 7 5.0 COc1ccc(CN2C(=O)CN[C@](c3cccc(C(F)(F)F)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
11238500 474693 0 None 3 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 572 8 2 7 4.7 COc1ccc(CN2C(=O)CN[C@](c3cccc(Cl)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL96313 474693 0 None 3 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 572 8 2 7 4.7 COc1ccc(CN2C(=O)CN[C@](c3cccc(Cl)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
11753582 474473 0 None 4 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 586 7 2 6 4.8 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(Br)cc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL94962 474473 0 None 4 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 586 7 2 6 4.8 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(Br)cc3)c3ccccc32)n1 10.1021/jm031115r
11397857 474662 0 None 6 2 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 496 7 2 6 3.7 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccc(Cl)cc32)c1 10.1021/jm031115r
CHEMBL96125 474662 0 None 6 2 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 496 7 2 6 3.7 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccc(Cl)cc32)c1 10.1021/jm031115r
11489946 474247 0 None 2 2 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 566 8 2 7 4.6 COc1ccc(CN2C(=O)CN[C@](c3cc(C)cc(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL93612 474247 0 None 2 2 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 566 8 2 7 4.6 COc1ccc(CN2C(=O)CN[C@](c3cc(C)cc(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL433406 488590 0 None -9 2 Human 6.6 pIC50 = 6.6 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 938 25 10 8 4.0 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)NC)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
44332803 19047 0 None None None Human 5.6 pIC50 = 5.6 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 335 3 0 5 3.6 COC(=O)C(c1ccc2c(c1)OCO2)c1cc(C)nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL103497 19047 0 None None None Human 5.6 pIC50 = 5.6 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 335 3 0 5 3.6 COC(=O)C(c1ccc2c(c1)OCO2)c1cc(C)nc2ccccc12 10.1016/S0960-894X(96)00551-3
9820754 218168 0 None None None Human 5.6 pIC50 = 5.6 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 371 3 0 5 4.4 COC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL320236 218168 0 None None None Human 5.6 pIC50 = 5.6 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 371 3 0 5 4.4 COC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
11410410 474436 0 None 25 2 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 560 7 2 4 6.2 Cc1cccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
CHEMBL94769 474436 0 None 25 2 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 560 7 2 4 6.2 Cc1cccc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
CHEMBL319660 486629 0 None 2 2 Human 7.5 pIC50 = 7.5 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 909 24 9 8 3.8 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
CHEMBL410694 488131 0 None None None Pig 8.5 pIC50 = 8.5 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 950 23 10 9 2.1 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
CHEMBL411965 488195 0 None None None Pig 8.5 pIC50 = 8.5 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 993 25 11 9 2.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
9915028 23715 19 None -20 3 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at ETA receptor in human pericardial smooth muscle cells assessed as inhibition of endothelin-1-induced [32H]arachidonic acid release incubated for 30 mins by radioactivity based assayAntagonist activity at ETA receptor in human pericardial smooth muscle cells assessed as inhibition of endothelin-1-induced [32H]arachidonic acid release incubated for 30 mins by radioactivity based assay
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1042/cs103s107s
CHEMBL111612 23715 19 None -20 3 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at ETA receptor in human pericardial smooth muscle cells assessed as inhibition of endothelin-1-induced [32H]arachidonic acid release incubated for 30 mins by radioactivity based assayAntagonist activity at ETA receptor in human pericardial smooth muscle cells assessed as inhibition of endothelin-1-induced [32H]arachidonic acid release incubated for 30 mins by radioactivity based assay
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1042/cs103s107s
11387934 216818 0 None 28 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 614 9 2 7 5.7 COc1ccc(CN2C(=O)CN[C@](c3cccc(-c4ccccc4)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL316453 216818 0 None 28 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 614 9 2 7 5.7 COc1ccc(CN2C(=O)CN[C@](c3cccc(-c4ccccc4)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
177372766 394391 0 None -2 4 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at ETA receptor in endothelin-1 stimulated human Pericardial smooth muscle cell assessed as inhibition of arachidonic acid release in presence of myo-[3H] inositol by anion exchange chromatographyAntagonist activity at ETA receptor in endothelin-1 stimulated human Pericardial smooth muscle cell assessed as inhibition of arachidonic acid release in presence of myo-[3H] inositol by anion exchange chromatography
ChEMBL 532 15 1 6 5.9 CCCCN(CCCC)C(=O)CN1[C@H](c2cc(OC)c3c(c2)OCO3)C[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1016/s0014-2999(98)00891-7
CHEMBL5687007 394391 0 None -2 4 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at ETA receptor in endothelin-1 stimulated human Pericardial smooth muscle cell assessed as inhibition of arachidonic acid release in presence of myo-[3H] inositol by anion exchange chromatographyAntagonist activity at ETA receptor in endothelin-1 stimulated human Pericardial smooth muscle cell assessed as inhibition of arachidonic acid release in presence of myo-[3H] inositol by anion exchange chromatography
ChEMBL 532 15 1 6 5.9 CCCCN(CCCC)C(=O)CN1[C@H](c2cc(OC)c3c(c2)OCO3)C[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1016/s0014-2999(98)00891-7
11353580 474800 0 None 21 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 566 9 2 7 4.6 CCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3ccc(OC)cc3)c3ccccc32)c1 10.1021/jm031115r
CHEMBL96932 474800 0 None 21 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 566 9 2 7 4.6 CCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3ccc(OC)cc3)c3ccccc32)c1 10.1021/jm031115r
177638577 393356 0 None None None Human 8.5 pIC50 = 8.5 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 533 10 1 9 5.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cc2)nc(-c2ncccn2)nc1OCC1CCC1 10.1016/j.ejmech.2023.115681
CHEMBL5632096 393356 0 None None None Human 8.5 pIC50 = 8.5 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 533 10 1 9 5.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cc2)nc(-c2ncccn2)nc1OCC1CCC1 10.1016/j.ejmech.2023.115681
177639295 393423 0 None None None Human 8.5 pIC50 = 8.5 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 562 10 1 10 4.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCC1CCCN(C)C1 10.1016/j.ejmech.2023.115681
CHEMBL5633230 393423 0 None None None Human 8.5 pIC50 = 8.5 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 562 10 1 10 4.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCC1CCCN(C)C1 10.1016/j.ejmech.2023.115681
10303258 317387 0 None 3 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 564 10 2 6 5.3 CCCCc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL415010 317387 0 None 3 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 564 10 2 6 5.3 CCCCc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
11168474 474769 0 None 9 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 526 7 2 6 4.1 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96723 474769 0 None 9 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 526 7 2 6 4.1 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3F)c3ccccc32)n1 10.1021/jm031115r
177639438 393429 0 None None None Human 8.5 pIC50 = 8.5 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 562 10 1 10 4.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cc2)nc(-c2ncccn2)nc1OCC1CCCN1C 10.1016/j.ejmech.2023.115681
CHEMBL5633395 393429 0 None None None Human 8.5 pIC50 = 8.5 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 562 10 1 10 4.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cc2)nc(-c2ncccn2)nc1OCC1CCCN1C 10.1016/j.ejmech.2023.115681
44384715 123130 0 None 177 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 559 9 1 9 5.2 CC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
CHEMBL174607 123130 0 None 177 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 559 9 1 9 5.2 CC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
11421392 474281 0 None 5 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(F)c3F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL93820 474281 0 None 5 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(F)c3F)c3ccccc32)n1 10.1021/jm031115r
177638163 393314 0 None None None Human 8.4 pIC50 = 8.4 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 519 11 1 9 4.8 C=CCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C)cc2)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
CHEMBL5631316 393314 0 None None None Human 8.4 pIC50 = 8.4 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 519 11 1 9 4.8 C=CCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C)cc2)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
177638487 393359 0 None None None Human 8.4 pIC50 = 8.4 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 505 11 1 9 4.5 C=CCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccccc2)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
CHEMBL5632169 393359 0 None None None Human 8.4 pIC50 = 8.4 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 505 11 1 9 4.5 C=CCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccccc2)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
11489318 474669 0 None 5 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 522 8 2 6 4.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCc3ccccc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96171 474669 0 None 5 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 522 8 2 6 4.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCc3ccccc3)c3ccccc32)n1 10.1021/jm031115r
177638205 393354 0 None None None Human 8.4 pIC50 = 8.4 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 547 12 1 9 5.6 CC/C=C/CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C)cc2)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
CHEMBL5632055 393354 0 None None None Human 8.4 pIC50 = 8.4 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 547 12 1 9 5.6 CC/C=C/CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C)cc2)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
177638724 393434 0 None None None Human 8.4 pIC50 = 8.4 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 589 12 1 9 6.6 CC/C=C/CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
CHEMBL5633488 393434 0 None None None Human 8.4 pIC50 = 8.4 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 589 12 1 9 6.6 CC/C=C/CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
CHEMBL94983 489418 0 None 7 2 Human 7.5 pIC50 = 7.5 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 924 26 10 9 2.9 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
11398818 332685 0 None 2 2 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 556 8 2 7 4.2 COc1ccc(CN2C(=O)CN[C@](c3ccccc3F)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL431460 332685 0 None 2 2 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 556 8 2 7 4.2 COc1ccc(CN2C(=O)CN[C@](c3ccccc3F)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
11156692 332636 0 None 2 2 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 522 7 2 6 4.3 Cc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL431087 332636 0 None 2 2 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 522 7 2 6 4.3 Cc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
10412464 23442 0 None 11 2 Human 6.5 pIC50 = 6.5 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 470 6 1 5 5.4 COc1ccc(CC2=C(c3ccc(Cl)c(Cl)c3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL10996 23442 0 None 11 2 Human 6.5 pIC50 = 6.5 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 470 6 1 5 5.4 COc1ccc(CC2=C(c3ccc(Cl)c(Cl)c3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
10410546 23716 0 None 37 2 Human 6.5 pIC50 = 6.5 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 432 7 1 6 4.1 COc1ccc(CC2=C(c3ccc(OC)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL11162 23716 0 None 37 2 Human 6.5 pIC50 = 6.5 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 432 7 1 6 4.1 COc1ccc(CC2=C(c3ccc(OC)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
15289330 199990 0 None 18 2 Human 7.5 pIC50 = 7.5 Functional
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 493 8 1 8 5.3 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OC)cc23)c1 10.1016/0960-894X(96)00232-6
CHEMBL285368 199990 0 None 18 2 Human 7.5 pIC50 = 7.5 Functional
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 493 8 1 8 5.3 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OC)cc23)c1 10.1016/0960-894X(96)00232-6
CHEMBL97431 489425 0 None 2 2 Human 6.5 pIC50 = 6.5 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 923 25 9 8 4.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
18995989 200708 0 None -2 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 583 9 1 9 6.6 COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OCc1ccccc1 10.1016/0960-894X(96)00232-6
CHEMBL29147 200708 0 None -2 2 Human 5.5 pIC50 = 5.5 Functional
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 583 9 1 9 6.6 COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OCc1ccccc1 10.1016/0960-894X(96)00232-6
11307120 221888 0 None -4 2 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 532 11 2 7 4.5 CCCCC[C@]1([C@H](Oc2nc(C)cc(C)n2)C(=O)O)NCC(=O)N(Cc2ccc(OC)cc2)c2ccccc21 10.1021/jm031115r
CHEMBL329744 221888 0 None -4 2 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 532 11 2 7 4.5 CCCCC[C@]1([C@H](Oc2nc(C)cc(C)n2)C(=O)O)NCC(=O)N(Cc2ccc(OC)cc2)c2ccccc21 10.1021/jm031115r
1009 399 28 None -1995 2 Human 5.4 pIC50 = 5.4 Functional
Eurofins cellular functional assay - Antagonist (EDNRA)Eurofins cellular functional assay - Antagonist (EDNRA)
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.6019/CHEMBL4507261
5310991 399 28 None -1995 2 Human 5.4 pIC50 = 5.4 Functional
Eurofins cellular functional assay - Antagonist (EDNRA)Eurofins cellular functional assay - Antagonist (EDNRA)
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.6019/CHEMBL4507261
CHEMBL332794 399 28 None -1995 2 Human 5.4 pIC50 = 5.4 Functional
Eurofins cellular functional assay - Antagonist (EDNRA)Eurofins cellular functional assay - Antagonist (EDNRA)
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.6019/CHEMBL4507261
11362537 217152 0 None 24 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 434 6 2 7 1.8 COc1cnc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)nc1 10.1021/jm031115r
CHEMBL318683 217152 0 None 24 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 434 6 2 7 1.8 COc1cnc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)nc1 10.1021/jm031115r
11167889 474704 0 None 1 2 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 496 7 2 6 3.7 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(Cl)ccc32)c1 10.1021/jm031115r
CHEMBL96351 474704 0 None 1 2 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 496 7 2 6 3.7 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(Cl)ccc32)c1 10.1021/jm031115r
11752174 346859 0 None 4 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 489 8 2 7 2.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCN(C)C)c3ccccc32)n1 10.1021/jm031115r
CHEMBL450628 346859 0 None 4 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 489 8 2 7 2.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCN(C)C)c3ccccc32)n1 10.1021/jm031115r
70686381 157872 0 None -1 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 486 7 1 6 5.7 CCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058368 157872 0 None -1 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 486 7 1 6 5.7 CCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
11785180 221007 0 None 1 2 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 492 8 2 7 3.1 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(OC)ccc32)c1 10.1021/jm031115r
CHEMBL327823 221007 0 None 1 2 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 492 8 2 7 3.1 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(OC)ccc32)c1 10.1021/jm031115r
CHEMBL1790448 484798 0 None None None Pig 8.4 pIC50 = 8.4 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 937 22 10 9 2.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)[C@H](C)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
CHEMBL293029 486390 0 None None None Pig 8.4 pIC50 = 8.4 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 936 22 10 9 1.7 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
CHEMBL410869 488143 0 None None None Pig 8.4 pIC50 = 8.4 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 965 25 10 9 3.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
177639028 393406 0 None None None Human 8.4 pIC50 = 8.4 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 503 9 1 9 3.9 CC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccccc2)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
CHEMBL5632906 393406 0 None None None Human 8.4 pIC50 = 8.4 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 503 9 1 9 3.9 CC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccccc2)c1Oc1ccccc1OC 10.1016/j.ejmech.2023.115681
10230546 216883 0 None 4 2 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 538 8 2 7 4.0 COc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL316878 216883 0 None 4 2 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 538 8 2 7 4.0 COc1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
9807691 200240 0 None 134 2 Human 8.3 pIC50 = 8.3 Functional
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 553 10 1 10 5.3 COc1cc2c(Sc3cc(OC)c(OC)c(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00232-6
CHEMBL287169 200240 0 None 134 2 Human 8.3 pIC50 = 8.3 Functional
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 553 10 1 10 5.3 COc1cc2c(Sc3cc(OC)c(OC)c(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00232-6
104865 1454 67 None -11 5 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.ejmech.2023.115681
3494 1454 67 None -11 5 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.ejmech.2023.115681
392 1454 67 None -11 5 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.ejmech.2023.115681
CHEMBL957 1454 67 None -11 5 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.ejmech.2023.115681
DB00559 1454 67 None -11 5 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.ejmech.2023.115681
177639533 393437 0 None None None Human 8.3 pIC50 = 8.3 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 529 10 1 9 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cc2)nc(-c2ncccn2)nc1OCC(F)F 10.1016/j.ejmech.2023.115681
CHEMBL5633531 393437 0 None None None Human 8.3 pIC50 = 8.3 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 529 10 1 9 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cc2)nc(-c2ncccn2)nc1OCC(F)F 10.1016/j.ejmech.2023.115681
177638630 393459 0 None None None Human 8.3 pIC50 = 8.3 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 577 11 1 9 6.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCC(C)C 10.1016/j.ejmech.2023.115681
CHEMBL5633844 393459 0 None None None Human 8.3 pIC50 = 8.3 Functional
Antagonist activity against human ET-1 by ELISA analysisAntagonist activity against human ET-1 by ELISA analysis
ChEMBL 577 11 1 9 6.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCC(C)C 10.1016/j.ejmech.2023.115681
44304492 196896 0 None 1 4 Human 8.3 pIC50 = 8.3 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 949 23 9 8 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL262993 196896 0 None 1 4 Human 8.3 pIC50 = 8.3 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 949 23 9 8 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10027018 198755 0 None None None Human 6.4 pIC50 = 6.4 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 454 4 1 5 5.1 O=C1OC(O)(c2ccc(Cl)c(Cl)c2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
CHEMBL275991 198755 0 None None None Human 6.4 pIC50 = 6.4 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 454 4 1 5 5.1 O=C1OC(O)(c2ccc(Cl)c(Cl)c2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
CHEMBL94907 489416 0 None 1 2 Human 6.4 pIC50 = 6.4 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 881 23 9 8 3.1 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
1009 399 28 None -1995 2 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human ETA receptor transfected in CHO cell membrane assessed as inhibition of 125I-labelled ET-1 binding to receptor incubated for 3 hrs by competition binding assayAntagonist activity at human ETA receptor transfected in CHO cell membrane assessed as inhibition of 125I-labelled ET-1 binding to receptor incubated for 3 hrs by competition binding assay
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.1042/cs103s107s
5310991 399 28 None -1995 2 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human ETA receptor transfected in CHO cell membrane assessed as inhibition of 125I-labelled ET-1 binding to receptor incubated for 3 hrs by competition binding assayAntagonist activity at human ETA receptor transfected in CHO cell membrane assessed as inhibition of 125I-labelled ET-1 binding to receptor incubated for 3 hrs by competition binding assay
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.1042/cs103s107s
CHEMBL332794 399 28 None -1995 2 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human ETA receptor transfected in CHO cell membrane assessed as inhibition of 125I-labelled ET-1 binding to receptor incubated for 3 hrs by competition binding assayAntagonist activity at human ETA receptor transfected in CHO cell membrane assessed as inhibition of 125I-labelled ET-1 binding to receptor incubated for 3 hrs by competition binding assay
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.1042/cs103s107s
10070783 197378 0 None 3 3 Human 6.4 pIC50 = 6.4 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 420 4 1 5 4.5 O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
CHEMBL267094 197378 0 None 3 3 Human 6.4 pIC50 = 6.4 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 420 4 1 5 4.5 O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
CHEMBL2370255 485552 0 None -13 2 Human 6.4 pIC50 = 6.4 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 937 27 9 8 4.8 CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL433349 488587 0 None -1 3 Human 6.4 pIC50 = 6.4 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 8 4.6 CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL2370254 485551 0 None 2 2 Human 5.4 pIC50 = 5.4 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 900 25 9 9 3.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
11168401 221791 0 None 18 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 522 9 2 8 3.1 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(OC)c(OC)cc32)c1 10.1021/jm031115r
CHEMBL329132 221791 0 None 18 2 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 522 9 2 8 3.1 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3cc(OC)c(OC)cc32)c1 10.1021/jm031115r
11156376 222142 0 None 5 2 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 504 9 3 7 2.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCCC(=O)O)c3ccccc32)n1 10.1021/jm031115r
CHEMBL330359 222142 0 None 5 2 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 504 9 3 7 2.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCCC(=O)O)c3ccccc32)n1 10.1021/jm031115r
CHEMBL318020 486619 0 None 8 2 Human 6.4 pIC50 = 6.4 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 939 26 10 9 3.0 CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
11330927 474396 0 None 8 2 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 606 9 2 6 5.9 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
CHEMBL94488 474396 0 None 8 2 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 606 9 2 6 5.9 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(Cl)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
10385531 222159 0 None None None Human 5.3 pIC50 = 5.3 Functional
Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.
ChEMBL 387 4 0 6 4.4 COC(=O)C(Oc1c2ccccc2nc2ccccc12)c1ccc2c(c1)OCO2 10.1016/S0960-894X(96)00551-3
CHEMBL330414 222159 0 None None None Human 5.3 pIC50 = 5.3 Functional
Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.
ChEMBL 387 4 0 6 4.4 COC(=O)C(Oc1c2ccccc2nc2ccccc12)c1ccc2c(c1)OCO2 10.1016/S0960-894X(96)00551-3
9865706 198427 0 None 1 2 Human 5.3 pIC50 = 5.3 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 400 4 1 5 4.1 Cc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm00008a002
CHEMBL273613 198427 0 None 1 2 Human 5.3 pIC50 = 5.3 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 400 4 1 5 4.1 Cc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm00008a002
CHEMBL264330 486125 0 None None None Pig 8.3 pIC50 = 8.3 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 949 21 9 8 4.3 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(C)(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
CHEMBL386850 487707 0 None None None Pig 8.3 pIC50 = 8.3 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 964 22 10 9 2.5 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(C)(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
11318409 474346 0 None 3 2 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 522 7 2 6 4.3 Cc1cccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)c1 10.1021/jm031115r
CHEMBL94212 474346 0 None 3 2 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 522 7 2 6 4.3 Cc1cccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)c1 10.1021/jm031115r
10187261 221038 0 None 3 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 542 7 2 6 4.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(Cl)c3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL327976 221038 0 None 3 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 542 7 2 6 4.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(Cl)c3)c3ccccc32)n1 10.1021/jm031115r
11785813 216578 0 None 8 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 526 7 2 6 4.1 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)cc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL314755 216578 0 None 8 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 526 7 2 6 4.1 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)cc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL408616 488024 0 None None None Pig 7.3 pIC50 = 7.3 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 973 23 10 9 3.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
9845562 19081 0 None 7 3 Human 7.3 pIC50 = 7.3 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(C)cc2)cc1 10.1021/jm00008a002
CHEMBL10374 19081 0 None 7 3 Human 7.3 pIC50 = 7.3 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(C)cc2)cc1 10.1021/jm00008a002
11742628 198520 0 None 25 3 Human 7.3 pIC50 = 7.3 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 416 5 1 6 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm00008a002
CHEMBL274383 198520 0 None 25 3 Human 7.3 pIC50 = 7.3 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 416 5 1 6 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm00008a002
9845562 19081 0 None 7 3 Human 7.3 pIC50 = 7.3 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(C)cc2)cc1 10.1021/jm00008a002
CHEMBL10374 19081 0 None 7 3 Human 7.3 pIC50 = 7.3 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(C)cc2)cc1 10.1021/jm00008a002
CHEMBL411797 488186 0 None 1 2 Human 6.3 pIC50 = 6.3 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 957 25 9 8 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10226239 474752 0 None 4 2 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 456 5 2 8 2.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3nnc(C)n3-c3ccccc32)n1 10.1021/jm031115r
CHEMBL96614 474752 0 None 4 2 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 456 5 2 8 2.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3nnc(C)n3-c3ccccc32)n1 10.1021/jm031115r
10027018 198755 0 None None None Human 6.3 pIC50 = 6.3 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 454 4 1 5 5.1 O=C1OC(O)(c2ccc(Cl)c(Cl)c2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
CHEMBL275991 198755 0 None None None Human 6.3 pIC50 = 6.3 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 454 4 1 5 5.1 O=C1OC(O)(c2ccc(Cl)c(Cl)c2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
44332578 18664 0 None None None Human 5.3 pIC50 = 5.3 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 413 3 0 5 5.6 CC(C)(C)OC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL100874 18664 0 None None None Human 5.3 pIC50 = 5.3 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 413 3 0 5 5.6 CC(C)(C)OC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
122272 197418 36 None -4 3 Human 6.2 pIC50 = 6.2 Functional
Antagonism of ET-1 induced increase in intracellular Ca+2 in vsm-A10 cellsAntagonism of ET-1 induced increase in intracellular Ca+2 in vsm-A10 cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00029a001
CHEMBL267458 197418 36 None -4 3 Human 6.2 pIC50 = 6.2 Functional
Antagonism of ET-1 induced increase in intracellular Ca+2 in vsm-A10 cellsAntagonism of ET-1 induced increase in intracellular Ca+2 in vsm-A10 cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00029a001
10047521 22943 0 None None None Human 6.2 pIC50 = 6.2 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 416 6 1 5 4.4 COc1ccc(CC2=C(c3ccc(C)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL10951 22943 0 None None None Human 6.2 pIC50 = 6.2 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 416 6 1 5 4.4 COc1ccc(CC2=C(c3ccc(C)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
11156301 160181 0 None 4 2 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 500 7 3 9 2.2 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3nnc(CC(=O)O)n3-c3ccccc32)n1 10.1021/jm031115r
CHEMBL2112377 160181 0 None 4 2 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 500 7 3 9 2.2 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3nnc(CC(=O)O)n3-c3ccccc32)n1 10.1021/jm031115r
9820754 218168 0 None None None Human 5.2 pIC50 = 5.2 Functional
Compound was tested for inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsCompound was tested for inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 371 3 0 5 4.4 COC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL320236 218168 0 None None None Human 5.2 pIC50 = 5.2 Functional
Compound was tested for inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsCompound was tested for inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 371 3 0 5 4.4 COC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
11203972 216534 0 None None None Human 5.2 pIC50 = 5.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 8 2 5 5.9 COc1ccccc1O[C@H](C(=O)O)[C@@]1(c2ccccc2)NCC(=O)N(Cc2c(Cl)cccc2Cl)c2ccccc21 10.1021/jm031115r
CHEMBL314511 216534 0 None None None Human 5.2 pIC50 = 5.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 8 2 5 5.9 COc1ccccc1O[C@H](C(=O)O)[C@@]1(c2ccccc2)NCC(=O)N(Cc2c(Cl)cccc2Cl)c2ccccc21 10.1021/jm031115r
CHEMBL2373085 485959 0 None None None Pig 8.2 pIC50 = 8.2 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 933 20 8 8 3.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
CHEMBL433837 488594 0 None None None Pig 8.2 pIC50 = 8.2 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 907 21 9 8 3.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
CHEMBL62641 489350 0 None None None Pig 8.2 pIC50 = 8.2 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 923 22 10 9 2.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
10187313 217066 0 None 18 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)cc3F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL318247 217066 0 None 18 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)cc3F)c3ccccc32)n1 10.1021/jm031115r
9890440 22570 0 None 301 2 Human 8.2 pIC50 = 8.2 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 460 6 1 7 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(C)c2)cc1 10.1021/jm00008a002
CHEMBL10924 22570 0 None 301 2 Human 8.2 pIC50 = 8.2 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 460 6 1 7 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(C)c2)cc1 10.1021/jm00008a002
11284285 216959 0 None 8 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 552 8 2 7 4.3 COc1ccc(CN2C(=O)CN[C@](c3cccc(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL317510 216959 0 None 8 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 552 8 2 7 4.3 COc1ccc(CN2C(=O)CN[C@](c3cccc(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
11307805 216971 0 None 3 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 586 7 2 6 4.8 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(Br)c3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL317589 216971 0 None 3 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 586 7 2 6 4.8 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(Br)c3)c3ccccc32)n1 10.1021/jm031115r
11283571 474483 0 None 7 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 508 7 2 6 4.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL95013 474483 0 None 7 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 508 7 2 6 4.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3)c3ccccc32)n1 10.1021/jm031115r
11364770 328626 0 None 5 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)c(F)c3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL420435 328626 0 None 5 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)c(F)c3)c3ccccc32)n1 10.1021/jm031115r
10209814 474175 0 None 7 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 562 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)c(F)c3F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL93084 474175 0 None 7 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 562 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccc(F)c(F)c3F)c3ccccc32)n1 10.1021/jm031115r
10163956 474474 0 None 10 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 500 7 3 9 1.5 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3nn[nH]n3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL94964 474474 0 None 10 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 500 7 3 9 1.5 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3nn[nH]n3)c3ccccc32)n1 10.1021/jm031115r
10166139 328327 0 None 2 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 550 7 2 6 4.9 Cc1cc(C)c(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)c(C)c1 10.1021/jm031115r
CHEMBL419136 328327 0 None 2 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 550 7 2 6 4.9 Cc1cc(C)c(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)c(C)c1 10.1021/jm031115r
11191999 474388 0 None 4 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)ccc3F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL94438 474388 0 None 4 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)ccc3F)c3ccccc32)n1 10.1021/jm031115r
11375934 474775 0 None 3 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 526 7 2 6 4.1 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(F)c3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96746 474775 0 None 3 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 526 7 2 6 4.1 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(F)c3)c3ccccc32)n1 10.1021/jm031115r
11478911 312233 0 None 4 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 598 7 2 6 4.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)c(F)c(F)c(F)c3F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL406551 312233 0 None 4 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 598 7 2 6 4.7 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3c(F)c(F)c(F)c(F)c3F)c3ccccc32)n1 10.1021/jm031115r
10298354 221494 0 None 15 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 462 7 3 7 1.8 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCO)c3ccccc32)n1 10.1021/jm031115r
CHEMBL328878 221494 0 None 15 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 462 7 3 7 1.8 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CCO)c3ccccc32)n1 10.1021/jm031115r
345351 23663 3 None 24 3 Human 6.2 pIC50 = 6.2 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 386 4 1 5 3.8 O=C1OC(O)(c2ccccc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
CHEMBL11131 23663 3 None 24 3 Human 6.2 pIC50 = 6.2 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 386 4 1 5 3.8 O=C1OC(O)(c2ccccc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm00008a002
CHEMBL329609 486726 0 None 3 2 Human 5.2 pIC50 = 5.2 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 922 25 9 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)[C@@H](C)CC 10.1021/jm00015a003
11202819 222044 0 None 1 2 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 499 6 3 8 3.2 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3c(C(=O)O)nc(C)n3-c3ccccc32)n1 10.1021/jm031115r
CHEMBL330045 222044 0 None 1 2 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 499 6 3 8 3.2 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCc3c(C(=O)O)nc(C)n3-c3ccccc32)n1 10.1021/jm031115r
11385689 222267 0 None 10 2 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 462 7 2 6 3.0 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)c1 10.1021/jm031115r
CHEMBL330629 222267 0 None 10 2 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 462 7 2 6 3.0 COc1cc(OC)cc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)c1 10.1021/jm031115r
44283270 202968 0 None -1659 4 Human 5.2 pIC50 = 5.2 Functional
Functional inhibition of ET-1 induced [Ca2+] increase in human neuroblastoma-derived SK-N-MC cells, which express Endothelin A receptorFunctional inhibition of ET-1 induced [Ca2+] increase in human neuroblastoma-derived SK-N-MC cells, which express Endothelin A receptor
ChEMBL 580 12 5 5 3.8 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1016/0960-894X(95)00237-N
44314579 202968 0 None -1659 4 Human 5.2 pIC50 = 5.2 Functional
Functional inhibition of ET-1 induced [Ca2+] increase in human neuroblastoma-derived SK-N-MC cells, which express Endothelin A receptorFunctional inhibition of ET-1 induced [Ca2+] increase in human neuroblastoma-derived SK-N-MC cells, which express Endothelin A receptor
ChEMBL 580 12 5 5 3.8 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1016/0960-894X(95)00237-N
CHEMBL306123 202968 0 None -1659 4 Human 5.2 pIC50 = 5.2 Functional
Functional inhibition of ET-1 induced [Ca2+] increase in human neuroblastoma-derived SK-N-MC cells, which express Endothelin A receptorFunctional inhibition of ET-1 induced [Ca2+] increase in human neuroblastoma-derived SK-N-MC cells, which express Endothelin A receptor
ChEMBL 580 12 5 5 3.8 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1016/0960-894X(95)00237-N
CHEMBL431124 202968 0 None -1659 4 Human 5.2 pIC50 = 5.2 Functional
Functional inhibition of ET-1 induced [Ca2+] increase in human neuroblastoma-derived SK-N-MC cells, which express Endothelin A receptorFunctional inhibition of ET-1 induced [Ca2+] increase in human neuroblastoma-derived SK-N-MC cells, which express Endothelin A receptor
ChEMBL 580 12 5 5 3.8 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1016/0960-894X(95)00237-N
18995991 200468 0 None 9 2 Human 7.2 pIC50 = 7.2 Functional
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 537 8 1 10 5.0 COc1cc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc(OC)c1OC 10.1016/0960-894X(96)00232-6
CHEMBL28920 200468 0 None 9 2 Human 7.2 pIC50 = 7.2 Functional
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 537 8 1 10 5.0 COc1cc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc(OC)c1OC 10.1016/0960-894X(96)00232-6
18995992 200025 0 None 3 2 Human 7.2 pIC50 = 7.2 Functional
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 507 7 1 9 5.0 COc1ccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC 10.1016/0960-894X(96)00232-6
CHEMBL28563 200025 0 None 3 2 Human 7.2 pIC50 = 7.2 Functional
Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.Inhibition of ET- 1 stimulated arachidonic acid release (AAR) in cultured rabbit renal vascular smooth muscle cells expressing the endothelin A receptor.
ChEMBL 507 7 1 9 5.0 COc1ccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC 10.1016/0960-894X(96)00232-6
11465096 197092 0 None None None Human 5.2 pIC50 = 5.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 450 6 2 7 2.5 CSc1cnc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)nc1 10.1021/jm031115r
CHEMBL264625 197092 0 None None None Human 5.2 pIC50 = 5.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 450 6 2 7 2.5 CSc1cnc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)nc1 10.1021/jm031115r
11235126 474789 0 None 52 2 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 405 5 2 6 2.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCCOc3ccccc32)n1 10.1021/jm031115r
CHEMBL96831 474789 0 None 52 2 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 405 5 2 6 2.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCCOc3ccccc32)n1 10.1021/jm031115r
11478553 328425 0 None 10 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 562 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)c(F)cc3F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL419879 328425 0 None 10 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 562 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)c(F)cc3F)c3ccccc32)n1 10.1021/jm031115r
11330570 474469 0 None 4 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 570 8 2 7 4.5 COc1ccc(CN2C(=O)CN[C@](c3ccc(F)c(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL94934 474469 0 None 4 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 570 8 2 7 4.5 COc1ccc(CN2C(=O)CN[C@](c3ccc(F)c(C)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
11155687 474696 0 None 12 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 472 7 2 6 3.2 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC3CC3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96318 474696 0 None 12 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 472 7 2 6 3.2 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC3CC3)c3ccccc32)n1 10.1021/jm031115r
10303311 216804 0 None 9 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 566 8 2 8 3.8 COC(=O)c1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL316301 216804 0 None 9 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 566 8 2 8 3.8 COC(=O)c1ccc(CN2C(=O)CN[C@](c3ccccc3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
11742628 198520 0 None 25 3 Human 8.1 pIC50 = 8.1 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 416 5 1 6 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm00008a002
CHEMBL274383 198520 0 None 25 3 Human 8.1 pIC50 = 8.1 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 416 5 1 6 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm00008a002
11477664 332891 0 None 6 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 506 10 2 8 2.4 COCCOCN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2nc(C)cc(C)n2)C(=O)O)c2ccccc21 10.1021/jm031115r
CHEMBL433173 332891 0 None 6 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 506 10 2 8 2.4 COCCOCN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2nc(C)cc(C)n2)C(=O)O)c2ccccc21 10.1021/jm031115r
11204331 222059 0 None -1 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 616 10 2 6 6.1 CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
CHEMBL330135 222059 0 None -1 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 616 10 2 6 6.1 CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3c(F)cccc3Cl)c3ccccc32)c1 10.1021/jm031115r
11377200 217909 0 None 11 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 638 8 2 6 6.1 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3cccc(-c4ccccc4)c3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL319754 217909 0 None 11 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 638 8 2 6 6.1 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3cccc(-c4ccccc4)c3)NCC(=O)N(Cc3c(F)cc(F)cc3F)c3ccccc32)n1 10.1021/jm031115r
11444738 329795 0 None 4 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 594 11 2 7 5.4 CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3ccc(OC)cc3)c3ccccc32)c1 10.1021/jm031115r
CHEMBL422068 329795 0 None 4 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 594 11 2 7 5.4 CCCCc1cccc([C@]2([C@H](Oc3nc(C)cc(C)n3)C(=O)O)NCC(=O)N(Cc3ccc(OC)cc3)c3ccccc32)c1 10.1021/jm031115r
11398658 474484 0 None 1 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)cc(F)c3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL95017 474484 0 None 1 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 544 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cc(F)cc(F)c3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL319719 486630 0 None -3 2 Human 7.2 pIC50 = 7.2 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 879 23 8 7 4.7 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL328942 486724 0 None 1 3 Human 7.2 pIC50 = 7.2 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 923 25 9 8 4.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
9980487 19607 0 None None None Human 6.2 pIC50 = 6.2 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 436 6 1 5 4.8 COc1ccc(CC2=C(c3ccc(Cl)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL10648 19607 0 None None None Human 6.2 pIC50 = 6.2 Functional
Antagonistic activity against human Endothelin A receptor expressed in LtKAntagonistic activity against human Endothelin A receptor expressed in LtK
ChEMBL 436 6 1 5 4.8 COc1ccc(CC2=C(c3ccc(Cl)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
10452089 18910 0 None None None Human 5.1 pIC50 = 5.1 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 375 3 0 5 4.1 COC(=O)C(c1ccc2c(c1)OCO2)c1c2c(nc3ccccc13)CCCC2 10.1016/S0960-894X(96)00551-3
CHEMBL102494 18910 0 None None None Human 5.1 pIC50 = 5.1 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 375 3 0 5 4.1 COC(=O)C(c1ccc2c(c1)OCO2)c1c2c(nc3ccccc13)CCCC2 10.1016/S0960-894X(96)00551-3
70694736 157871 0 None -1 2 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 472 6 1 6 5.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(C)nc4ccccc43)cc2)c1C 10.1016/j.bmc.2012.06.011
CHEMBL2058367 157871 0 None -1 2 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 472 6 1 6 5.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3c(C)nc4ccccc43)cc2)c1C 10.1016/j.bmc.2012.06.011
134136255 279737 0 None None None Human 7.1 pIC50 = 7.1 Functional
Agonist activity at ETA receptor in human SKNMC cells assessed as induction of Ca2+ mobilization by fluorimetric methodAgonist activity at ETA receptor in human SKNMC cells assessed as induction of Ca2+ mobilization by fluorimetric method
ChEMBL 663 11 2 10 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(F)(C(F)(F)F)C(F)(F)F)cc2)nc(-c2ncccn2)nc1OCCO 10.1016/j.ejmech.2016.06.006
CHEMBL3891334 279737 0 None None None Human 7.1 pIC50 = 7.1 Functional
Agonist activity at ETA receptor in human SKNMC cells assessed as induction of Ca2+ mobilization by fluorimetric methodAgonist activity at ETA receptor in human SKNMC cells assessed as induction of Ca2+ mobilization by fluorimetric method
ChEMBL 663 11 2 10 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(F)(C(F)(F)F)C(F)(F)F)cc2)nc(-c2ncccn2)nc1OCCO 10.1016/j.ejmech.2016.06.006
10047521 22943 0 None None None Human 6.1 pIC50 = 6.1 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 416 6 1 5 4.4 COc1ccc(CC2=C(c3ccc(C)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL10951 22943 0 None None None Human 6.1 pIC50 = 6.1 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 416 6 1 5 4.4 COc1ccc(CC2=C(c3ccc(C)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
44332807 216872 0 None None None Human 5.1 pIC50 = 5.1 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 447 5 0 5 6.0 O=C(OCc1ccccc1)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL316792 216872 0 None None None Human 5.1 pIC50 = 5.1 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 447 5 0 5 6.0 O=C(OCc1ccccc1)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
44332624 18530 0 None None None Human 4.1 pIC50 = 4.1 Functional
Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.
ChEMBL 356 3 1 4 3.7 NC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL100120 18530 0 None None None Human 4.1 pIC50 = 4.1 Functional
Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.Compound was tested for its ability to inhibit Endothelin A receptor induced arachidonic acid release(AARA) in rabbit renal artery vascular smooth muscles.
ChEMBL 356 3 1 4 3.7 NC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
10336018 202201 0 None -10 2 Human 5.1 pIC50 = 5.1 Functional
Antagonism of ET1 induced increase in intracellular Ca+2 in rabbit carotid artery ringsAntagonism of ET1 induced increase in intracellular Ca+2 in rabbit carotid artery rings
ChEMBL 318 3 2 5 3.0 Cc1noc(NS(=O)(=O)c2cccc3c(O)cccc23)c1C 10.1021/jm00029a001
CHEMBL30228 202201 0 None -10 2 Human 5.1 pIC50 = 5.1 Functional
Antagonism of ET1 induced increase in intracellular Ca+2 in rabbit carotid artery ringsAntagonism of ET1 induced increase in intracellular Ca+2 in rabbit carotid artery rings
ChEMBL 318 3 2 5 3.0 Cc1noc(NS(=O)(=O)c2cccc3c(O)cccc23)c1C 10.1021/jm00029a001
CHEMBL265614 484236 17 None None None Pig 8.1 pIC50 = 8.1 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 949 23 9 8 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
CHEMBL269189 486288 0 None None None Pig 8.1 pIC50 = 8.1 Functional
Antagonist activity against ET-A from porcine heart membranesAntagonist activity against ET-A from porcine heart membranes
ChEMBL 967 24 9 9 4.0 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
104865 1454 67 None -11 5 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmc.2012.06.011
3494 1454 67 None -11 5 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmc.2012.06.011
392 1454 67 None -11 5 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmc.2012.06.011
CHEMBL957 1454 67 None -11 5 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmc.2012.06.011
DB00559 1454 67 None -11 5 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmc.2012.06.011
70694737 157876 0 None -1 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 544 10 1 7 6.5 CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058372 157876 0 None -1 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 544 10 1 7 6.5 CCCCc1nc2ccc(OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
11432418 216604 0 None 6 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 522 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3C)c3ccccc32)n1 10.1021/jm031115r
CHEMBL314946 216604 0 None 6 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 522 7 2 6 4.3 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3C)c3ccccc32)n1 10.1021/jm031115r
44332638 18724 0 None None None Human 5.1 pIC50 = 5.1 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 477 6 0 6 6.0 COc1ccc(COC(=O)C(c2ccc3c(c2)OCO3)c2c3ccccc3nc3ccccc23)cc1 10.1016/S0960-894X(96)00551-3
CHEMBL101239 18724 0 None None None Human 5.1 pIC50 = 5.1 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 477 6 0 6 6.0 COc1ccc(COC(=O)C(c2ccc3c(c2)OCO3)c2c3ccccc3nc3ccccc23)cc1 10.1016/S0960-894X(96)00551-3
11489174 222031 0 None -1 2 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 514 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC3CCCCC3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL329943 222031 0 None -1 2 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 514 7 2 6 4.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(CC3CCCCC3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL216082 485166 0 None -20 2 Human 6.1 pIC50 = 6.1 Functional
Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cellsInhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular smooth muscle cells
ChEMBL 956 25 8 7 5.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
44332624 18530 0 None None None Human 5.1 pIC50 = 5.1 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 356 3 1 4 3.7 NC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL100120 18530 0 None None None Human 5.1 pIC50 = 5.1 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 356 3 1 4 3.7 NC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
44332546 216851 0 None None None Human 5.1 pIC50 = 5.1 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 491 5 0 7 5.7 O=C(OCc1ccc2c(c1)OCO2)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL316648 216851 0 None None None Human 5.1 pIC50 = 5.1 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 491 5 0 7 5.7 O=C(OCc1ccc2c(c1)OCO2)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
9955200 23637 0 None 53 3 Human 8.1 pIC50 = 8.1 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 446 6 1 7 3.8 COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL11115 23637 0 None 53 3 Human 8.1 pIC50 = 8.1 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 446 6 1 7 3.8 COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
11376627 217265 0 None 1 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 7 2 6 5.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(C(F)(F)F)c3)c3ccccc32)n1 10.1021/jm031115r
CHEMBL319007 217265 0 None 1 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 576 7 2 6 5.0 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3cccc(C(F)(F)F)c3)c3ccccc32)n1 10.1021/jm031115r
11307457 474495 0 None 5 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 556 8 2 7 4.2 COc1ccc(CN2C(=O)CN[C@](c3cccc(F)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
CHEMBL95095 474495 0 None 5 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 556 8 2 7 4.2 COc1ccc(CN2C(=O)CN[C@](c3cccc(F)c3)([C@H](Oc3nc(C)cc(C)n3)C(=O)O)c3ccccc32)cc1 10.1021/jm031115r
70684239 157875 0 None -1 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 528 9 1 6 6.8 CCCCc1nc2ccc(C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058371 157875 0 None -1 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 528 9 1 6 6.8 CCCCc1nc2ccc(C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
70694738 157877 0 None 1 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 548 9 1 6 7.2 CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058373 157877 0 None 1 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 548 9 1 6 7.2 CCCCc1nc2ccc(Cl)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
70686382 157874 0 None 1 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 514 9 1 6 6.5 CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058370 157874 0 None 1 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 514 9 1 6 6.5 CCCCc1nc2ccccc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
70696780 157878 0 None 1 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 592 9 1 6 7.3 CCCCc1nc2ccc(Br)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
CHEMBL2058374 157878 0 None 1 2 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 592 9 1 6 7.3 CCCCc1nc2ccc(Br)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/j.bmc.2012.06.011
44213651 18647 0 None None None Human 6.1 pIC50 = 6.1 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 343 3 1 4 4.2 OCC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL100795 18647 0 None None None Human 6.1 pIC50 = 6.1 Functional
Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.Antagonistic activity against endothelin A receptor in rabbit renal artery vascular smooth muscle cells.
ChEMBL 343 3 1 4 4.2 OCC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
11441050 474700 0 None 85 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 403 5 2 5 3.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCCCc3ccccc32)n1 10.1021/jm031115r
CHEMBL96331 474700 0 None 85 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 403 5 2 5 3.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCCCc3ccccc32)n1 10.1021/jm031115r
11488556 474734 0 None 10 2 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 482 5 2 6 2.6 CN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2ncc(Br)cn2)C(=O)O)c2ccccc21 10.1021/jm031115r
CHEMBL96520 474734 0 None 10 2 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 482 5 2 6 2.6 CN1C(=O)CN[C@](c2ccccc2)([C@H](Oc2ncc(Br)cn2)C(=O)O)c2ccccc21 10.1021/jm031115r
9980487 19607 0 None None None Human 6.0 pIC50 = 6.0 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 436 6 1 5 4.8 COc1ccc(CC2=C(c3ccc(Cl)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
CHEMBL10648 19607 0 None None None Human 6.0 pIC50 = 6.0 Functional
Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.
ChEMBL 436 6 1 5 4.8 COc1ccc(CC2=C(c3ccc(Cl)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm00008a002
11456110 474708 0 None -1 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 592 8 2 7 4.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3OC(F)(F)F)c3ccccc32)n1 10.1021/jm031115r
CHEMBL96387 474708 0 None -1 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligandAntagonist activity towards human recombinant Endothelin A receptor expressed in chinese hamster ovary (CHO) cells determined using [125I]ET1 as radioligand
ChEMBL 592 8 2 7 4.9 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(Cc3ccccc3OC(F)(F)F)c3ccccc32)n1 10.1021/jm031115r
70686380 157870 0 None -1 2 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 458 6 1 6 5.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3cnc4ccccc43)cc2)c1C 10.1016/j.bmc.2012.06.011
CHEMBL2058366 157870 0 None -1 2 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cellsAntagonist activity at human endothelin receptor subtype A expressed in CHO-K1 cells
ChEMBL 458 6 1 6 5.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cn3cnc4ccccc43)cc2)c1C 10.1016/j.bmc.2012.06.011
44311232 469050 0 None None None Rat 10.0 pKd = 10 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 658 13 2 13 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70293 469050 0 None None None Rat 10.0 pKd = 10 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 658 13 2 13 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
9939238 469068 0 None None None Rat 9.7 pKd = 9.7 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 637 12 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70385 469068 0 None None None Rat 9.7 pKd = 9.7 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 637 12 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
9809919 469315 0 None None None Rat 9.3 pKd = 9.3 Functional
Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 665 13 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL72037 469315 0 None None None Rat 9.3 pKd = 9.3 Functional
Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 665 13 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44212539 469039 0 None None None Rat 9.0 pKd = 9 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 671 12 2 12 5.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70203 469039 0 None None None Rat 9.0 pKd = 9 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 671 12 2 12 5.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44311233 469052 0 None None None Rat 9.0 pKd = 9 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 630 12 2 13 4.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70303 469052 0 None None None Rat 9.0 pKd = 9 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 630 12 2 13 4.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44311516 469060 0 None None None Rat 8.0 pKd = 8 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 678 12 2 12 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70339 469060 0 None None None Rat 8.0 pKd = 8 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 678 12 2 12 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44311527 469064 0 None None None Rat 8.0 pKd = 8 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 675 12 2 11 7.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2cccs2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70365 469064 0 None None None Rat 8.0 pKd = 8 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 675 12 2 11 7.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2cccs2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
18184234 124953 0 None None None Rat 7.0 pKd = 7.0 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 605 15 2 10 4.2 CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL177802 124953 0 None None None Rat 7.0 pKd = 7.0 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 605 15 2 10 4.2 CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
9807456 123240 0 None None None Rat 7.0 pKd = 7.0 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 545 9 1 9 4.8 C#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL175435 123240 0 None None None Rat 7.0 pKd = 7.0 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 545 9 1 9 4.8 C#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
44311285 202385 0 None None None Rat 7.9 pKd = 7.9 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 635 13 2 10 6.4 CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(Oc2ccccc2OC)c(OCCOC(=O)Nc2ccccn2)n1 10.1016/S0960-894X(97)00400-9
CHEMBL303428 202385 0 None None None Rat 7.9 pKd = 7.9 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 635 13 2 10 6.4 CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(Oc2ccccc2OC)c(OCCOC(=O)Nc2ccccn2)n1 10.1016/S0960-894X(97)00400-9
9917706 257655 0 None None None Rat 6.9 pKd = 6.9 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 659 15 2 11 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL367444 257655 0 None None None Rat 6.9 pKd = 6.9 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 659 15 2 11 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
9869444 197559 0 None None None Human 6.9 pKd = 6.9 Functional
Inhibition of contraction of ET-1 induced rabbit femoral artery, which are known to express predominantly ETA receptorsInhibition of contraction of ET-1 induced rabbit femoral artery, which are known to express predominantly ETA receptors
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2c1 10.1016/0960-894X(96)00170-9
CHEMBL268751 197559 0 None None None Human 6.9 pKd = 6.9 Functional
Inhibition of contraction of ET-1 induced rabbit femoral artery, which are known to express predominantly ETA receptorsInhibition of contraction of ET-1 induced rabbit femoral artery, which are known to express predominantly ETA receptors
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2c1 10.1016/0960-894X(96)00170-9
9848132 474462 0 None None None Rat 5.9 pKd = 5.9 Functional
Compound was evaluated for the antagonism at the Endothelin A receptor in isolated rat aortic ringsCompound was evaluated for the antagonism at the Endothelin A receptor in isolated rat aortic rings
ChEMBL 483 6 1 8 2.8 Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL94918 474462 0 None None None Rat 5.9 pKd = 5.9 Functional
Compound was evaluated for the antagonism at the Endothelin A receptor in isolated rat aortic ringsCompound was evaluated for the antagonism at the Endothelin A receptor in isolated rat aortic rings
ChEMBL 483 6 1 8 2.8 Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
10281606 257590 0 None None None Rat 6.8 pKd = 6.8 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 575 9 2 10 4.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL367382 257590 0 None None None Rat 6.8 pKd = 6.8 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 575 9 2 10 4.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
44311284 469169 0 None None None Rat 7.8 pKd = 7.8 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 635 12 2 10 6.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)C)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL71070 469169 0 None None None Rat 7.8 pKd = 7.8 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 635 12 2 10 6.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)C)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44311346 203212 0 None None None Rat 6.8 pKd = 6.8 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 681 13 2 13 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCSCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL308088 203212 0 None None None Rat 6.8 pKd = 6.8 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 681 13 2 13 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCSCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL1790962 484819 0 None None None Pig 7.7 pKd = 7.7 Functional
ETA receptor antagonist activity was measured by inhibition of ET-1 induced vasoconstriction in isolated porcine coronary arteryETA receptor antagonist activity was measured by inhibition of ET-1 induced vasoconstriction in isolated porcine coronary artery
ChEMBL 2476 46 32 36 -4.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00077a013
CHEMBL2373291 485962 0 None None None Pig 7.7 pKd = 7.7 Functional
ETA receptor antagonist activity was measured by inhibition of ET-1 induced vasoconstriction in isolated porcine coronary arteryETA receptor antagonist activity was measured by inhibition of ET-1 induced vasoconstriction in isolated porcine coronary artery
ChEMBL 2516 46 32 36 -3.9 CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00077a013
44311528 469081 0 None None None Rat 7.7 pKd = 7.7 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 633 12 2 10 6.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70487 469081 0 None None None Rat 7.7 pKd = 7.7 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 633 12 2 10 6.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
10122675 198739 0 None None None Rat 7.7 pKd = 7.7 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 682 12 2 13 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
CHEMBL275897 198739 0 None None None Rat 7.7 pKd = 7.7 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 682 12 2 13 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
10146640 474440 0 None None None Rat 7.7 pKd = 7.7 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 689 12 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
CHEMBL94786 474440 0 None None None Rat 7.7 pKd = 7.7 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 689 12 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
10212088 197026 0 None None None Rat 6.7 pKd = 6.7 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 688 12 2 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
CHEMBL264035 197026 0 None None None Rat 6.7 pKd = 6.7 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 688 12 2 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
10211772 119322 0 None None None Rat 6.6 pKd = 6.6 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 660 11 2 12 4.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
CHEMBL163638 119322 0 None None None Rat 6.6 pKd = 6.6 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 660 11 2 12 4.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
9917072 124853 0 None None None Rat 6.6 pKd = 6.6 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 619 16 2 10 4.6 CCCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL177538 124853 0 None None None Rat 6.6 pKd = 6.6 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 619 16 2 10 4.6 CCCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
9809270 259229 0 None None None Rat 6.6 pKd = 6.6 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 622 14 2 12 2.3 CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL368738 259229 0 None None None Rat 6.6 pKd = 6.6 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 622 14 2 12 2.3 CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
9870830 473662 29 None None None Human 7.6 pKd = 7.6 Functional
Antagonism of ET-1 induced contraction of rabbit femoral artery rings (Endothelin A receptor mediated)Antagonism of ET-1 induced contraction of rabbit femoral artery rings (Endothelin A receptor mediated)
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
CHEMBL8981 473662 29 None None None Human 7.6 pKd = 7.6 Functional
Antagonism of ET-1 induced contraction of rabbit femoral artery rings (Endothelin A receptor mediated)Antagonism of ET-1 induced contraction of rabbit femoral artery rings (Endothelin A receptor mediated)
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
44311283 202415 0 None None None Rat 7.6 pKd = 7.6 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 649 11 2 10 6.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)(C)C)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL303649 202415 0 None None None Rat 7.6 pKd = 7.6 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 649 11 2 10 6.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)(C)C)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
23670447 6168 2 None None None Human 7.6 pKd = 7.6 Functional
pA2 value towards endothelin receptor A was determined as functional ETA antagonismpA2 value towards endothelin receptor A was determined as functional ETA antagonism
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0960-894x(97)10151-2
9871594 6168 2 None None None Human 7.6 pKd = 7.6 Functional
pA2 value towards endothelin receptor A was determined as functional ETA antagonismpA2 value towards endothelin receptor A was determined as functional ETA antagonism
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0960-894x(97)10151-2
999 6168 2 None None None Human 7.6 pKd = 7.6 Functional
pA2 value towards endothelin receptor A was determined as functional ETA antagonismpA2 value towards endothelin receptor A was determined as functional ETA antagonism
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0960-894x(97)10151-2
CHEMBL1204799 6168 2 None None None Human 7.6 pKd = 7.6 Functional
pA2 value towards endothelin receptor A was determined as functional ETA antagonismpA2 value towards endothelin receptor A was determined as functional ETA antagonism
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0960-894x(97)10151-2
CHEMBL25438 6168 2 None None None Human 7.6 pKd = 7.6 Functional
pA2 value towards endothelin receptor A was determined as functional ETA antagonismpA2 value towards endothelin receptor A was determined as functional ETA antagonism
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0960-894x(97)10151-2
44386169 259273 0 None None None Rat 7.6 pKd = 7.6 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 690 12 2 14 3.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
CHEMBL368996 259273 0 None None None Rat 7.6 pKd = 7.6 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 690 12 2 14 3.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
10190108 258592 0 None None None Rat 7.6 pKd = 7.6 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 681 12 2 12 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
CHEMBL368386 258592 0 None None None Rat 7.6 pKd = 7.6 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 681 12 2 12 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
10211781 257657 0 None None None Rat 7.6 pKd = 7.6 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
CHEMBL367453 257657 0 None None None Rat 7.6 pKd = 7.6 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
18184229 122384 0 None None None Rat 6.5 pKd = 6.5 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 605 15 2 10 4.2 CCCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL171950 122384 0 None None None Rat 6.5 pKd = 6.5 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 605 15 2 10 4.2 CCCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
9894460 473657 11 None None None Rat 8.5 pKd = 8.5 Functional
Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/S0960-894X(96)00617-8
CHEMBL8978 473657 11 None None None Rat 8.5 pKd = 8.5 Functional
Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/S0960-894X(96)00617-8
10311570 38536 0 None None None Human 8.5 pKd = 8.5 Functional
pA2 value towards endothelin receptor A was determined as functional ETA antagonismpA2 value towards endothelin receptor A was determined as functional ETA antagonism
ChEMBL 520 10 1 9 4.7 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(97)10151-2
CHEMBL1205068 38536 0 None None None Human 8.5 pKd = 8.5 Functional
pA2 value towards endothelin receptor A was determined as functional ETA antagonismpA2 value towards endothelin receptor A was determined as functional ETA antagonism
ChEMBL 520 10 1 9 4.7 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(97)10151-2
9830495 259040 0 None None None Rat 6.5 pKd = 6.5 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 618 14 2 9 5.0 CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL368617 259040 0 None None None Rat 6.5 pKd = 6.5 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 618 14 2 9 5.0 CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
9874557 257654 0 None None None Rat 6.5 pKd = 6.5 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 667 15 2 10 5.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL367443 257654 0 None None None Rat 6.5 pKd = 6.5 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 667 15 2 10 5.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
9864880 202463 0 None None None Human 7.5 pKd = 7.5 Functional
pA2 value towards endothelin receptor A was determined as functional ETA antagonismpA2 value towards endothelin receptor A was determined as functional ETA antagonism
ChEMBL 384 4 1 6 3.7 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc4nsnc4c3)cccc12 10.1016/s0960-894x(97)10151-2
CHEMBL303902 202463 0 None None None Human 7.5 pKd = 7.5 Functional
pA2 value towards endothelin receptor A was determined as functional ETA antagonismpA2 value towards endothelin receptor A was determined as functional ETA antagonism
ChEMBL 384 4 1 6 3.7 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc4nsnc4c3)cccc12 10.1016/s0960-894x(97)10151-2
9810571 124146 0 None None None Rat 5.5 pKd = 5.5 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 731 18 2 13 5.0 CCCS(=O)(=O)NCCOc1nc(-c2cc(OC)c(OC)c(OC)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL176997 124146 0 None None None Rat 5.5 pKd = 5.5 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 731 18 2 13 5.0 CCCS(=O)(=O)NCCOc1nc(-c2cc(OC)c(OC)c(OC)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
9873255 122410 0 None None None Rat 6.5 pKd = 6.5 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 591 14 2 10 3.8 CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL172071 122410 0 None None None Rat 6.5 pKd = 6.5 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 591 14 2 10 3.8 CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL2373292 485963 0 None None None Pig 7.4 pKd = 7.4 Functional
ETA receptor antagonist activity was measured by inhibition of ET-1 induced vasoconstriction in isolated porcine coronary arteryETA receptor antagonist activity was measured by inhibition of ET-1 induced vasoconstriction in isolated porcine coronary artery
ChEMBL 2490 45 32 36 -4.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00077a013
44298982 391016 0 None None None Rat 6.4 pKd = 6.4 Functional
Functional antagonism against ETA receptor in rat aortic rings expressed as pA2 valueFunctional antagonism against ETA receptor in rat aortic rings expressed as pA2 value
ChEMBL 445 7 1 6 5.2 CCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc(OC)cc1 10.1016/S0960-894X(97)00319-3
CHEMBL55621 391016 0 None None None Rat 6.4 pKd = 6.4 Functional
Functional antagonism against ETA receptor in rat aortic rings expressed as pA2 valueFunctional antagonism against ETA receptor in rat aortic rings expressed as pA2 value
ChEMBL 445 7 1 6 5.2 CCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc(OC)cc1 10.1016/S0960-894X(97)00319-3
10122442 258591 0 None None None Rat 6.4 pKd = 6.4 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 660 14 2 11 5.6 CCCCNC(=O)OCC#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL368383 258591 0 None None None Rat 6.4 pKd = 6.4 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 660 14 2 11 5.6 CCCCNC(=O)OCC#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
18184194 258468 0 None None None Rat 5.3 pKd = 5.3 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 712 15 2 12 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL368107 258468 0 None None None Rat 5.3 pKd = 5.3 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 712 15 2 12 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
44311345 469142 0 None None None Rat 8.3 pKd = 8.3 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 663 13 3 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CCNCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70895 469142 0 None None None Rat 8.3 pKd = 8.3 Functional
Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Evaluation for functional inhibitory potency prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 663 13 3 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CCNCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
177372766 394391 0 None None None Rat 8.3 pKd = 8.3 Functional
Antagonist activity to ETA receptor in Sprague-Dawley rat aorta assessed as induction of vessel ring contraction preincubated for 15 minsAntagonist activity to ETA receptor in Sprague-Dawley rat aorta assessed as induction of vessel ring contraction preincubated for 15 mins
ChEMBL 532 15 1 6 5.9 CCCCN(CCCC)C(=O)CN1[C@H](c2cc(OC)c3c(c2)OCO3)C[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1016/s0014-2999(98)00891-7
CHEMBL5687007 394391 0 None None None Rat 8.3 pKd = 8.3 Functional
Antagonist activity to ETA receptor in Sprague-Dawley rat aorta assessed as induction of vessel ring contraction preincubated for 15 minsAntagonist activity to ETA receptor in Sprague-Dawley rat aorta assessed as induction of vessel ring contraction preincubated for 15 mins
ChEMBL 532 15 1 6 5.9 CCCCN(CCCC)C(=O)CN1[C@H](c2cc(OC)c3c(c2)OCO3)C[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1016/s0014-2999(98)00891-7
104865 1454 67 None None None Rat 7.3 pKd = 7.3 Functional
Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
3494 1454 67 None None None Rat 7.3 pKd = 7.3 Functional
Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
392 1454 67 None None None Rat 7.3 pKd = 7.3 Functional
Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
CHEMBL957 1454 67 None None None Rat 7.3 pKd = 7.3 Functional
Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
DB00559 1454 67 None None None Rat 7.3 pKd = 7.3 Functional
Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)Compound was evaluated for in vitro functional inhibitory potency for prevention of ET-1 induced constriction of rat aortic rings (ETA receptors)
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
10005597 238532 0 None None None Rat 6.3 pKd = 6.3 Functional
In vitro antagonistic activity against endothelin A receptor in isolated rat aortic ringsIn vitro antagonistic activity against endothelin A receptor in isolated rat aortic rings
ChEMBL 485 7 1 7 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cc(OC)ccc3OC)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL348407 238532 0 None None None Rat 6.3 pKd = 6.3 Functional
In vitro antagonistic activity against endothelin A receptor in isolated rat aortic ringsIn vitro antagonistic activity against endothelin A receptor in isolated rat aortic rings
ChEMBL 485 7 1 7 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cc(OC)ccc3OC)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
10168597 124097 0 None None None Rat 6.3 pKd = 6.3 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cccnc1 10.1016/s0960-894x(02)01084-3
CHEMBL176741 124097 0 None None None Rat 6.3 pKd = 6.3 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cccnc1 10.1016/s0960-894x(02)01084-3
CHEMBL411171 488158 0 None None None Pig 5.3 pKd = 5.3 Functional
ETA receptor antagonist activity was measured by inhibition of ET-1 induced vasoconstriction in isolated porcine coronary arteryETA receptor antagonist activity was measured by inhibition of ET-1 induced vasoconstriction in isolated porcine coronary artery
ChEMBL 2488 47 31 35 -3.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00077a013
10233400 256619 0 None None None Rat 7.3 pKd = 7.3 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccncc1 10.1016/s0960-894x(02)01084-3
CHEMBL366885 256619 0 None None None Rat 7.3 pKd = 7.3 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccncc1 10.1016/s0960-894x(02)01084-3
10305334 256980 0 None None None Rat 6.3 pKd = 6.3 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 680 12 2 11 6.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
CHEMBL367036 256980 0 None None None Rat 6.3 pKd = 6.3 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 680 12 2 11 6.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
192311 216907 1 None None None Pig 7.2 pKd = 7.2 Functional
Antagonistic activity towards ET- l-induced contraction in porcine coronary arteriesAntagonistic activity towards ET- l-induced contraction in porcine coronary arteries
ChEMBL 513 11 5 4 2.8 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31702 216907 1 None None None Pig 7.2 pKd = 7.2 Functional
Antagonistic activity towards ET- l-induced contraction in porcine coronary arteriesAntagonistic activity towards ET- l-induced contraction in porcine coronary arteries
ChEMBL 513 11 5 4 2.8 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
10457385 222165 0 None None None Rat 6.2 pKd = 6.2 Functional
Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)
ChEMBL 469 6 1 8 2.5 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
155511294 222165 0 None None None Rat 6.2 pKd = 6.2 Functional
Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)
ChEMBL 469 6 1 8 2.5 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL330424 222165 0 None None None Rat 6.2 pKd = 6.2 Functional
Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)
ChEMBL 469 6 1 8 2.5 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL4435789 222165 0 None None None Rat 6.2 pKd = 6.2 Functional
Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)Compound was evaluated for the antagonism at the Endothelin A receptor (G-protein coupled endothelin A)
ChEMBL 469 6 1 8 2.5 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
11755275 444728 0 None None None Rat 5.2 pKd = 5.2 Functional
Functional antagonism against ETA receptor in rat aortic rings expressed as pA2 valueFunctional antagonism against ETA receptor in rat aortic rings expressed as pA2 value
ChEMBL 489 9 1 7 4.8 CCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)c(=O)n2Cc1cc(OC)ccc1OC 10.1016/S0960-894X(97)00319-3
CHEMBL59537 444728 0 None None None Rat 5.2 pKd = 5.2 Functional
Functional antagonism against ETA receptor in rat aortic rings expressed as pA2 valueFunctional antagonism against ETA receptor in rat aortic rings expressed as pA2 value
ChEMBL 489 9 1 7 4.8 CCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)c(=O)n2Cc1cc(OC)ccc1OC 10.1016/S0960-894X(97)00319-3
9831249 122474 0 None None None Rat 6.2 pKd = 6.2 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 672 14 2 10 6.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL172297 122474 0 None None None Rat 6.2 pKd = 6.2 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 672 14 2 10 6.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
10146377 123181 0 None None None Rat 8.1 pKd = 8.1 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 662 11 2 14 3.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
CHEMBL175058 123181 0 None None None Rat 8.1 pKd = 8.1 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 662 11 2 14 3.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
44384715 123130 0 None None None Rat 7.2 pKd = 7.2 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 559 9 1 9 5.2 CC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL174607 123130 0 None None None Rat 7.2 pKd = 7.2 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 559 9 1 9 5.2 CC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
104865 1454 67 None None None Rat 7.1 pKd = 7.1 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(02)01084-3
3494 1454 67 None None None Rat 7.1 pKd = 7.1 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(02)01084-3
392 1454 67 None None None Rat 7.1 pKd = 7.1 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(02)01084-3
CHEMBL957 1454 67 None None None Rat 7.1 pKd = 7.1 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(02)01084-3
DB00559 1454 67 None None None Rat 7.1 pKd = 7.1 Functional
Potency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic ringsPotency on ETA receptor assessed by inhibition of the contraction induced by ET-1 in rat aortic rings
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(02)01084-3
9853077 122403 0 None None None Rat 6.1 pKd = 6.1 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 696 13 2 12 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL172030 122403 0 None None None Rat 6.1 pKd = 6.1 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 696 13 2 12 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
9961131 260038 0 None None None Rat 6.1 pKd = 6.1 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 650 15 2 12 3.1 CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL369676 260038 0 None None None Rat 6.1 pKd = 6.1 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 650 15 2 12 3.1 CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
9830773 258136 0 None None None Rat 7.0 pKd = 7.0 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 636 14 2 12 2.8 CCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL367958 258136 0 None None None Rat 7.0 pKd = 7.0 Functional
In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)In vitro inhibitory potency for preventing ET-1 induced constriction of rat aortic rings (ETA receptor)
ChEMBL 636 14 2 12 2.8 CCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
10096179 350975 0 None None None Human 8.7 pKi = 8.7 Functional
Antagonist activity against human ETA receptor using CHO cellsAntagonist activity against human ETA receptor using CHO cells
ChEMBL 468 9 1 5 5.7 CCOc1ccc(-c2cc(C)nc(OC(C(=O)O)C(C)(c3ccccc3)c3ccccc3)n2)cc1 10.1016/s0960-894x(03)00236-1
CHEMBL46311 350975 0 None None None Human 8.7 pKi = 8.7 Functional
Antagonist activity against human ETA receptor using CHO cellsAntagonist activity against human ETA receptor using CHO cells
ChEMBL 468 9 1 5 5.7 CCOc1ccc(-c2cc(C)nc(OC(C(=O)O)C(C)(c3ccccc3)c3ccccc3)n2)cc1 10.1016/s0960-894x(03)00236-1
10070 927 52 None None None Human 6.7 pA2 = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 18780830
25099191 927 52 None None None Human 6.7 pA2 = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 18780830
CHEMBL2165326 927 52 None None None Human 6.7 pA2 = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 18780830
DB15059 927 52 None None None Human 6.7 pA2 = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 18780830
197712 807 76 None None None Human 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
3951 807 76 None None None Human 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
4337 807 76 None None None Human 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
6918493 807 76 None None None Human 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
CHEMBL1111 807 76 None None None Human 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
CHEMBL302753 807 76 None None None Human 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
DB06403 807 76 None None None Human 7.1 pA2 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
101039204 1466 45 None None None Human 7.2 pA2 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 7647976
443289 1466 45 None None None Human 7.2 pA2 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 7647976
997 1466 45 None None None Human 7.2 pA2 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 7647976
CHEMBL314691 1466 45 None None None Human 7.2 pA2 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 7647976
CHEMBL4095638 1466 45 None None None Human 7.2 pA2 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 7647976
DB12054 1466 45 None None None Human 7.2 pA2 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 7647976
104865 1454 67 None None None Rat 7.2 pA2 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 8035319
3494 1454 67 None None None Rat 7.2 pA2 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 8035319
392 1454 67 None None None Rat 7.2 pA2 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 8035319
CHEMBL957 1454 67 None None None Rat 7.2 pA2 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 8035319
DB00559 1454 67 None None None Rat 7.2 pA2 = 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 8035319
216235 7338 38 None None None Human 8.0 pA2 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 9171878
3548 7338 38 None None None Human 8.0 pA2 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 9171878
3950 7338 38 None None None Human 8.0 pA2 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 9171878
CHEMBL282724 7338 38 None None None Human 8.0 pA2 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 9171878
DB06268 7338 38 None None None Human 8.0 pA2 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 9171878
3913 8151 0 None None None Rat 8.4 pA2 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 926 12 9 10 1.9 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)CC(=O)N1CCC(CC1)c1ccccc1)c1cccs1)C 7780649
5311469 8151 0 None None None Rat 8.4 pA2 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 926 12 9 10 1.9 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)CC(=O)N1CCC(CC1)c1ccccc1)c1cccs1)C 7780649
23670447 6168 2 None None None Human 8.7 pA2 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10066864
23670447 6168 2 None None None Human 8.7 pA2 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 9023329
9871594 6168 2 None None None Human 8.7 pA2 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10066864
9871594 6168 2 None None None Human 8.7 pA2 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 9023329
999 6168 2 None None None Human 8.7 pA2 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10066864
999 6168 2 None None None Human 8.7 pA2 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 9023329
CHEMBL1204799 6168 2 None None None Human 8.7 pA2 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10066864
CHEMBL1204799 6168 2 None None None Human 8.7 pA2 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 9023329
CHEMBL25438 6168 2 None None None Human 8.7 pA2 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10066864
CHEMBL25438 6168 2 None None None Human 8.7 pA2 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 9023329
159594 1080 38 None None None Human 9.2 pA2 = 9.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8632312
3487 1080 38 None None None Human 9.2 pA2 = 9.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8632312
CHEMBL9194 1080 38 None None None Human 9.2 pA2 = 9.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8632312
DB06199 1080 38 None None None Human 9.2 pA2 = 9.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8632312
12286 1953 39 None None None Human 9.5 pA2 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 9399983
6433095 1953 39 None None None Human 9.5 pA2 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 9399983
CHEMBL109648 1953 39 None None None Human 9.5 pA2 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 9399983
DB06677 1953 39 None None None Human 9.5 pA2 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 9399983
2527 333383 75 None 1 2 Human 8.4 pIC50 = 8.4 Functional
NoneNone
Drug Central 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 None
5340 333383 75 None 1 2 Human 8.4 pIC50 = 8.4 Functional
NoneNone
Drug Central 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 None
CHEMBL437 333383 75 None 1 2 Human 8.4 pIC50 = 8.4 Functional
NoneNone
Drug Central 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 None
DB06147 333383 75 None 1 2 Human 8.4 pIC50 = 8.4 Functional
NoneNone
Drug Central 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 None
4458 38359 47 None -1 3 Human 8.2 pIC50 = 8.2 Functional
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
Drug Central 309 3 1 6 1.6 CC(=O)N(c1onc(C)c1C)S(=O)(=O)c1ccc(N)cc1 None
6662 38359 47 None -1 3 Human 8.2 pIC50 = 8.2 Functional
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
Drug Central 309 3 1 6 1.6 CC(=O)N(c1onc(C)c1C)S(=O)(=O)c1ccc(N)cc1 None
CHEMBL1200910 38359 47 None -1 3 Human 8.2 pIC50 = 8.2 Functional
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
Drug Central 309 3 1 6 1.6 CC(=O)N(c1onc(C)c1C)S(=O)(=O)c1ccc(N)cc1 None
DB14033 38359 47 None -1 3 Human 8.2 pIC50 = 8.2 Functional
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
Drug Central 309 3 1 6 1.6 CC(=O)N(c1onc(C)c1C)S(=O)(=O)c1ccc(N)cc1 None
2529 347569 76 None -102 4 Human 8.2 pIC50 = 8.2 Functional
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
Drug Central 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C None
5344 347569 76 None -102 4 Human 8.2 pIC50 = 8.2 Functional
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
Drug Central 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C None
CHEMBL453 347569 76 None -102 4 Human 8.2 pIC50 = 8.2 Functional
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
Drug Central 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C None
DB00263 347569 76 None -102 4 Human 8.2 pIC50 = 8.2 Functional
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
Drug Central 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C None
8260 1098 43 None 141 2 Human 7.3 pIC50 = 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 479 8 1 9 3.9 COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 None
9912992 1098 43 None 141 2 Human 7.3 pIC50 = 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 479 8 1 9 3.9 COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 None
CHEMBL3989834 1098 43 None 141 2 Human 7.3 pIC50 = 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 479 8 1 9 3.9 COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 None
14322 3648 0 None None None Human 7.4 pIC50 = 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 30992315
107810 3461 29 None None None Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 604 12 4 6 3.4 CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccccn1)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C 7647976
998 3461 29 None None None Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 604 12 4 6 3.4 CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccccn1)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C 7647976
CHEMBL352396 3461 29 None None None Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 604 12 4 6 3.4 CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccccn1)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C 7647976
197712 807 76 None 85 2 Human 7.7 pIC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
3951 807 76 None 85 2 Human 7.7 pIC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
4337 807 76 None 85 2 Human 7.7 pIC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
6918493 807 76 None 85 2 Human 7.7 pIC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
CHEMBL1111 807 76 None 85 2 Human 7.7 pIC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
CHEMBL302753 807 76 None 85 2 Human 7.7 pIC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
DB06403 807 76 None 85 2 Human 7.7 pIC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 15139756
3539 8957 55 None None None Human 8.3 pIC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 424 6 1 9 2.7 COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 15956965
9910224 8957 55 None None None Human 8.3 pIC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 424 6 1 9 2.7 COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 15956965
CHEMBL1628688 8957 55 None None None Human 8.3 pIC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 424 6 1 9 2.7 COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 15956965
DB06629 8957 55 None None None Human 8.3 pIC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 424 6 1 9 2.7 COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 15956965
10070 927 52 None 288 2 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 18780830
25099191 927 52 None 288 2 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 18780830
CHEMBL2165326 927 52 None 288 2 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 18780830
DB15059 927 52 None 288 2 Human 8.5 pIC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 18780830
1000 7122 0 None None None Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 14 2 9 6.1 CCCCn1ncc(c1c1ccc(cc1OCc1ccccc1C(=O)O)OC)/C=C(/C(=O)O)\Cc1cc2OCOc2cc1OC 9694916
5311425 7122 0 None None None Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 14 2 9 6.1 CCCCn1ncc(c1c1ccc(cc1OCc1ccccc1C(=O)O)OC)/C=C(/C(=O)O)\Cc1cc2OCOc2cc1OC 9694916
CHEMBL1628624 7122 0 None None None Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 614 14 2 9 6.1 CCCCn1ncc(c1c1ccc(cc1OCc1ccccc1C(=O)O)OC)/C=C(/C(=O)O)\Cc1cc2OCOc2cc1OC 9694916
13748 2951 0 None None None Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 568 12 2 11 1.8 COCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC4=C(C=C3)OCO4 None
155097467 2951 0 None None None Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 568 12 2 11 1.8 COCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC4=C(C=C3)OCO4 None
16004692 4984 61 None 107 2 Human 9.3 pIC50 = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 22862294
4809 4984 61 None 107 2 Human 9.3 pIC50 = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 22862294
7352 4984 61 None 107 2 Human 9.3 pIC50 = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 22862294
CHEMBL2103873 4984 61 None 107 2 Human 9.3 pIC50 = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 22862294
DB08932 4984 61 None 107 2 Human 9.3 pIC50 = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 22862294
131845706 7061 8 None None None Human 7.8 pIC50 None 7.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 2562 51 34 38 -6.5 NCCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(=O)O)CCSC)[C@H](O)C)CC(=O)O)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)C(C)C)CC(=O)O)CCC(=O)N)Cc1c[nH]cn1)Cc1ccccc1 7647976
71308726 7061 8 None None None Human 7.8 pIC50 None 7.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 2562 51 34 38 -6.5 NCCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(=O)O)CCSC)[C@H](O)C)CC(=O)O)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)C(C)C)CC(=O)O)CCC(=O)N)Cc1c[nH]cn1)Cc1ccccc1 7647976
995 7061 8 None None None Human 7.8 pIC50 None 7.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 2562 51 34 38 -6.5 NCCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(=O)O)CCSC)[C@H](O)C)CC(=O)O)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)C(C)C)CC(=O)O)CCC(=O)N)Cc1c[nH]cn1)Cc1ccccc1 7647976
CHEMBL1222310 7061 8 None None None Human 7.8 pIC50 None 7.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 2562 51 34 38 -6.5 NCCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(=O)O)CCSC)[C@H](O)C)CC(=O)O)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)C(C)C)CC(=O)O)CCC(=O)N)Cc1c[nH]cn1)Cc1ccccc1 7647976
CHEMBL4524099 7061 8 None None None Human 7.8 pIC50 None 7.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 2562 51 34 38 -6.5 NCCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(=O)O)CCSC)[C@H](O)C)CC(=O)O)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)C(C)C)CC(=O)O)CCC(=O)N)Cc1c[nH]cn1)Cc1ccccc1 7647976
P13208 7061 8 None None None Human 7.8 pIC50 None 7.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 2562 51 34 38 -6.5 NCCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(=O)O)CCSC)[C@H](O)C)CC(=O)O)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)C(C)C)CC(=O)O)CCC(=O)N)Cc1c[nH]cn1)Cc1ccccc1 7647976
16212950 3213 24 None None None Human 8.2 pIC50 None 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 7647976
989 3213 24 None None None Human 8.2 pIC50 None 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 7647976
CHEMBL3775234 3213 24 None None None Human 8.2 pIC50 None 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 7647976
P05305 3213 24 None None None Human 8.2 pIC50 None 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 7647976
P22387 3213 24 None None None Human 8.2 pIC50 None 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 7647976
P22388 3213 24 None None None Human 8.2 pIC50 None 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 7647976
16219332 3217 0 None None None Human 8.2 pIC50 None 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 2545 46 33 35 -3.8 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1[nH]cnc1)CO)Cc1c[nH]c2c1cccc2 7647976
990 3217 0 None None None Human 8.2 pIC50 None 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 2545 46 33 35 -3.8 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1[nH]cnc1)CO)Cc1c[nH]c2c1cccc2 7647976
P20800 3217 0 None None None Human 8.2 pIC50 None 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 2545 46 33 35 -3.8 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1[nH]cnc1)CO)Cc1c[nH]c2c1cccc2 7647976
108002 7104 25 None None None Rat 9.4 pKB = 9.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 8201588
3528 7104 25 None None None Rat 9.4 pKB = 9.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 8201588
CHEMBL8823 7104 25 None None None Rat 9.4 pKB = 9.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 8201588


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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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ity		 Common
name		 GPCRdb
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selectivity		 # Tested
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(-log)		 Activity
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Type		 Assay
Description		 Source

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weight		 Rot
Bonds		 H don

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28230148 470549 65 None None None Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 320 3 2 6 0.7 CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)nc21 10.1038/s41467-023-40064-9
3229 470549 65 None None None Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 320 3 2 6 0.7 CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)nc21 10.1038/s41467-023-40064-9
CHEMBL826 470549 65 None None None Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 320 3 2 6 0.7 CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)nc21 10.1038/s41467-023-40064-9
DB00467 470549 65 None None None Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 320 3 2 6 0.7 CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)nc21 10.1038/s41467-023-40064-9
41684 64851 70 None None None Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
CHEMBL1401 64851 70 None None None Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
DB00507 64851 70 None None None Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
54677470 448057 75 None None None Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 351 2 2 6 2.0 Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 10.1038/s41467-023-40064-9
CHEMBL599 448057 75 None None None Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 351 2 2 6 2.0 Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 10.1038/s41467-023-40064-9
DB00814 448057 75 None None None Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 351 2 2 6 2.0 Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1 10.1038/s41467-023-40064-9
4829 444400 68 None None None Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 356 7 1 5 3.2 CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1 10.1038/s41467-023-40064-9
CHEMBL595 444400 68 None None None Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 356 7 1 5 3.2 CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1 10.1038/s41467-023-40064-9
DB01132 444400 68 None None None Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 356 7 1 5 3.2 CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1 10.1038/s41467-023-40064-9
104865 1454 67 None None None Human 7.5 pAC50 = 7.5 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1038/s41467-023-40064-9
3494 1454 67 None None None Human 7.5 pAC50 = 7.5 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1038/s41467-023-40064-9
392 1454 67 None None None Human 7.5 pAC50 = 7.5 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1038/s41467-023-40064-9
CHEMBL957 1454 67 None None None Human 7.5 pAC50 = 7.5 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1038/s41467-023-40064-9
DB00559 1454 67 None None None Human 7.5 pAC50 = 7.5 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1038/s41467-023-40064-9
1209 3407 55 None None None Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
203 3407 55 None None None Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
3386 3407 55 None None None Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
CHEMBL41 3407 55 None None None Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
DB00472 3407 55 None None None Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 309 6 1 2 4.4 CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F 10.1038/s41467-023-40064-9
5329102 387203 55 None None None Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
CHEMBL535 387203 55 None None None Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
DB01268 387203 55 None None None Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
135398513 138412 85 None None None Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 225 4 3 8 -0.9 Nc1nc(O)c2ncn(COCCO)c2n1 10.1038/s41467-023-40064-9
2022 138412 85 None None None Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 225 4 3 8 -0.9 Nc1nc(O)c2ncn(COCCO)c2n1 10.1038/s41467-023-40064-9
CHEMBL184 138412 85 None None None Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 225 4 3 8 -0.9 Nc1nc(O)c2ncn(COCCO)c2n1 10.1038/s41467-023-40064-9
DB00787 138412 85 None None None Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human EDNRA in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 225 4 3 8 -0.9 Nc1nc(O)c2ncn(COCCO)c2n1 10.1038/s41467-023-40064-9
CHEMBL2370066 485514 0 None None None Human 7.9 pEC50 = 7.9 Binding
Effective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cellsEffective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 924 26 10 9 2.9 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL315841 486604 0 None None None Human 7.8 pEC50 = 7.8 Binding
Effective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cellsEffective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 909 24 9 8 3.8 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00070a001
CHEMBL2370067 485515 0 None None None Human 5.7 pEC50 = 5.7 Binding
Effective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cellsEffective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 865 24 8 8 4.1 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](N)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@H](C=O)Cc1c[nH]c2ccccc12)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL407269 487952 0 None None None Human 7.6 pEC50 = 7.6 Binding
Effective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cellsEffective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 939 26 10 9 3.0 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL313344 486529 0 None None None Human 5.6 pEC50 = 5.6 Binding
Effective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cellsEffective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 900 25 9 9 3.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL387200 487718 0 None None None Human 6.2 pEC50 = 6.2 Binding
Effective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cellsEffective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 956 25 8 7 5.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL86703 489393 0 None None None Human 5.2 pEC50 = 5.2 Binding
Effective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cellsEffective concentration against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 909 24 9 8 3.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(C)C 10.1021/jm00070a001
44284437 200163 0 None None None Human 11.0 pIC50 = 11.0 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 520 9 4 8 3.5 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(O)CO)c1 10.1016/j.bmcl.2004.01.008
CHEMBL286621 200163 0 None None None Human 11.0 pIC50 = 11.0 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 520 9 4 8 3.5 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(O)CO)c1 10.1016/j.bmcl.2004.01.008
44284405 200521 0 None None None Human 11.0 pIC50 = 11.0 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 532 10 2 7 5.4 COCC(C)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
CHEMBL289634 200521 0 None None None Human 11.0 pIC50 = 11.0 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 532 10 2 7 5.4 COCC(C)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
44284287 316800 0 None None None Human 11.0 pIC50 = 11.0 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 532 10 3 7 5.2 CCC(CO)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
CHEMBL411925 316800 0 None None None Human 11.0 pIC50 = 11.0 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 532 10 3 7 5.2 CCC(CO)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
11017304 233162 0 None None None Pig 10.9 pIC50 = 10.9 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 579 11 1 9 5.8 CCc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(SC)cn2)cc1 10.1021/jm0102304
CHEMBL332922 233162 0 None None None Pig 10.9 pIC50 = 10.9 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 579 11 1 9 5.8 CCc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(SC)cn2)cc1 10.1021/jm0102304
44284288 200310 0 None None None Human 10.9 pIC50 = 10.9 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 559 9 2 7 4.9 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)C(=O)N(C)C)c1 10.1016/j.bmcl.2004.01.008
CHEMBL287683 200310 0 None None None Human 10.9 pIC50 = 10.9 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 559 9 2 7 4.9 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)C(=O)N(C)C)c1 10.1016/j.bmcl.2004.01.008
44284292 332841 0 None None None Human 10.9 pIC50 = 10.9 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 518 8 3 7 4.9 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)(C)O)c1 10.1016/j.bmcl.2004.01.008
CHEMBL432856 332841 0 None None None Human 10.9 pIC50 = 10.9 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 518 8 3 7 4.9 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)(C)O)c1 10.1016/j.bmcl.2004.01.008
9852318 23918 9 None None None Rat 10.8 pIC50 = 10.8 Binding
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL112624 23918 9 None None None Rat 10.8 pIC50 = 10.8 Binding
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1016/j.bmcl.2016.06.014
11082446 24214 0 None None None Pig 10.8 pIC50 = 10.8 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 581 12 1 11 4.6 COc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2Oc2cccc(OC)c2)nc1 10.1021/jm0102304
CHEMBL114380 24214 0 None None None Pig 10.8 pIC50 = 10.8 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 581 12 1 11 4.6 COc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2Oc2cccc(OC)c2)nc1 10.1021/jm0102304
10897569 24439 0 None None None Pig 10.7 pIC50 = 10.7 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 645 11 1 10 5.7 COc1ccccc1Sc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCOc1ncc(Br)cn1 10.1021/jm0102304
CHEMBL115724 24439 0 None None None Pig 10.7 pIC50 = 10.7 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 645 11 1 10 5.7 COc1ccccc1Sc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCOc1ncc(Br)cn1 10.1021/jm0102304
10227760 201126 0 None None None Human 10.7 pIC50 = 10.7 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 481 6 2 7 4.9 CC(=O)c1c(C)c(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
CHEMBL294291 201126 0 None None None Human 10.7 pIC50 = 10.7 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 481 6 2 7 4.9 CC(=O)c1c(C)c(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
10163017 449586 0 None None None Human 10.7 pIC50 = 10.7 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 482 6 3 8 4.6 C/C(=N\O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
CHEMBL60058 449586 0 None None None Human 10.7 pIC50 = 10.7 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 482 6 3 8 4.6 C/C(=N\O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
44284236 240902 0 None None None Human 10.7 pIC50 = 10.7 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 504 9 3 7 4.5 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCCO)c1 10.1016/j.bmcl.2004.01.008
CHEMBL35984 240902 0 None None None Human 10.7 pIC50 = 10.7 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 504 9 3 7 4.5 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCCO)c1 10.1016/j.bmcl.2004.01.008
72548703 317107 0 None None None Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]-endothelin-1 from human recombinant ETA receptor after 120 mins by scintillation counting analysisDisplacement of [125I]-endothelin-1 from human recombinant ETA receptor after 120 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
CHEMBL4128926 317107 0 None None None Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]-endothelin-1 from human recombinant ETA receptor after 120 mins by scintillation counting analysisDisplacement of [125I]-endothelin-1 from human recombinant ETA receptor after 120 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
16212950 3213 24 None None None Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cellsDisplacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cells
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1016/j.bmc.2016.03.006
989 3213 24 None None None Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cellsDisplacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cells
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1016/j.bmc.2016.03.006
CHEMBL3775234 3213 24 None None None Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cellsDisplacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cells
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1016/j.bmc.2016.03.006
P05305 3213 24 None None None Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cellsDisplacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cells
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1016/j.bmc.2016.03.006
P22387 3213 24 None None None Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cellsDisplacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cells
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1016/j.bmc.2016.03.006
P22388 3213 24 None None None Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cellsDisplacement of [125I]Endothelin-1 from human recombinant Endothelin-1 receptor expressed in CHO cells
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1016/j.bmc.2016.03.006
16212950 3213 24 None None None Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1016/j.bmc.2016.11.014
989 3213 24 None None None Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1016/j.bmc.2016.11.014
CHEMBL3775234 3213 24 None None None Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1016/j.bmc.2016.11.014
P05305 3213 24 None None None Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1016/j.bmc.2016.11.014
P22387 3213 24 None None None Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1016/j.bmc.2016.11.014
P22388 3213 24 None None None Human 10.6 pIC50 = 10.6 Binding
Displacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1016/j.bmc.2016.11.014
44284288 200310 0 None None None Human 10.6 pIC50 = 10.6 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 559 9 2 7 4.9 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)C(=O)N(C)C)c1 10.1016/j.bmcl.2004.01.008
CHEMBL287683 200310 0 None None None Human 10.6 pIC50 = 10.6 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 559 9 2 7 4.9 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)C(=O)N(C)C)c1 10.1016/j.bmcl.2004.01.008
44284405 200521 0 None None None Human 10.6 pIC50 = 10.6 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 532 10 2 7 5.4 COCC(C)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
CHEMBL289634 200521 0 None None None Human 10.6 pIC50 = 10.6 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 532 10 2 7 5.4 COCC(C)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
9873636 347901 0 None None None Rat 10.6 pIC50 = 10.6 Binding
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 607 10 1 10 6.4 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2cc3ccccc3s2)nc1 10.1016/j.bmcl.2016.06.014
CHEMBL4538570 347901 0 None None None Rat 10.6 pIC50 = 10.6 Binding
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 607 10 1 10 6.4 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2cc3ccccc3s2)nc1 10.1016/j.bmcl.2016.06.014
44381151 122169 0 None None None Pig 10.6 pIC50 = 10.6 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 671 13 1 10 6.3 CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(Oc2ccccc2OC)c(OCCOc2ncc(Br)cn2)n1 10.1016/s0960-894x(01)00682-5
CHEMBL170908 122169 0 None None None Pig 10.6 pIC50 = 10.6 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 671 13 1 10 6.3 CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(Oc2ccccc2OC)c(OCCOc2ncc(Br)cn2)n1 10.1016/s0960-894x(01)00682-5
16212950 3213 24 None None None Human 10.6 pIC50 = 10.6 Binding
Inhibition of ETA receptor (unknown origin)Inhibition of ETA receptor (unknown origin)
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1021/acschembio.7b00481
989 3213 24 None None None Human 10.6 pIC50 = 10.6 Binding
Inhibition of ETA receptor (unknown origin)Inhibition of ETA receptor (unknown origin)
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1021/acschembio.7b00481
CHEMBL3775234 3213 24 None None None Human 10.6 pIC50 = 10.6 Binding
Inhibition of ETA receptor (unknown origin)Inhibition of ETA receptor (unknown origin)
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1021/acschembio.7b00481
P05305 3213 24 None None None Human 10.6 pIC50 = 10.6 Binding
Inhibition of ETA receptor (unknown origin)Inhibition of ETA receptor (unknown origin)
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1021/acschembio.7b00481
P22387 3213 24 None None None Human 10.6 pIC50 = 10.6 Binding
Inhibition of ETA receptor (unknown origin)Inhibition of ETA receptor (unknown origin)
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1021/acschembio.7b00481
P22388 3213 24 None None None Human 10.6 pIC50 = 10.6 Binding
Inhibition of ETA receptor (unknown origin)Inhibition of ETA receptor (unknown origin)
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1021/acschembio.7b00481
44284266 274352 0 None None None Human 10.6 pIC50 = 10.6 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 531 8 2 7 4.6 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CN(C)C(C)=O)c1 10.1016/j.bmcl.2004.01.008
CHEMBL37427 274352 0 None None None Human 10.6 pIC50 = 10.6 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 531 8 2 7 4.6 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CN(C)C(C)=O)c1 10.1016/j.bmcl.2004.01.008
11039156 24371 0 None None None Pig 10.6 pIC50 = 10.6 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 581 11 1 10 5.2 COc1cccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(SC)cn2)c1 10.1021/jm0102304
CHEMBL115333 24371 0 None None None Pig 10.6 pIC50 = 10.6 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 581 11 1 10 5.2 COc1cccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(SC)cn2)c1 10.1021/jm0102304
10206855 201044 0 None None None Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 493 7 2 7 5.0 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)C2CC2)c1 10.1021/jm030528p
CHEMBL293830 201044 0 None None None Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 493 7 2 7 5.0 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)C2CC2)c1 10.1021/jm030528p
10185556 202716 0 None None None Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 503 6 2 8 3.8 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(S(C)(=O)=O)c1 10.1021/jm030528p
CHEMBL304460 202716 0 None None None Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 503 6 2 8 3.8 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(S(C)(=O)=O)c1 10.1021/jm030528p
10228523 462144 0 None None None Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 495 7 2 7 5.3 CCC(=O)c1c(C)c(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
CHEMBL60367 462144 0 None None None Human 10.5 pIC50 = 10.5 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 495 7 2 7 5.3 CCC(=O)c1c(C)c(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
44284238 200302 0 None None None Human 10.5 pIC50 = 10.5 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 490 8 3 7 4.2 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCO)c1 10.1016/j.bmcl.2004.01.008
CHEMBL287622 200302 0 None None None Human 10.5 pIC50 = 10.5 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 490 8 3 7 4.2 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCO)c1 10.1016/j.bmcl.2004.01.008
10152810 38687 2 None None None Rat 10.5 pIC50 = 10.5 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 538 10 1 9 4.8 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1F 10.1016/s0960-894x(98)00301-1
CHEMBL1206706 38687 2 None None None Rat 10.5 pIC50 = 10.5 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 538 10 1 9 4.8 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1F 10.1016/s0960-894x(98)00301-1
159594 1080 38 None None None Human 10.5 pIC50 = 10.5 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm970101g
3487 1080 38 None None None Human 10.5 pIC50 = 10.5 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm970101g
CHEMBL9194 1080 38 None None None Human 10.5 pIC50 = 10.5 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm970101g
DB06199 1080 38 None None None Human 10.5 pIC50 = 10.5 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm970101g
10962637 24380 0 None None None Rat 10.5 pIC50 = 10.5 Binding
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 549 10 2 9 4.3 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(CO)cn2)cc1 10.1021/jm000538f
CHEMBL115372 24380 0 None None None Rat 10.5 pIC50 = 10.5 Binding
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 549 10 2 9 4.3 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(CO)cn2)cc1 10.1021/jm000538f
159594 1080 38 None None None Human 10.5 pIC50 = 10.5 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm990171i
3487 1080 38 None None None Human 10.5 pIC50 = 10.5 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm990171i
CHEMBL9194 1080 38 None None None Human 10.5 pIC50 = 10.5 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm990171i
DB06199 1080 38 None None None Human 10.5 pIC50 = 10.5 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm990171i
11767155 26016 0 None None None Pig 10.4 pIC50 = 10.4 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 596 10 1 9 5.9 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3ccccn3)cn2)cc1 10.1021/jm0102304
CHEMBL1181545 26016 0 None None None Pig 10.4 pIC50 = 10.4 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 596 10 1 9 5.9 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3ccccn3)cn2)cc1 10.1021/jm0102304
44284041 200471 0 None None None Human 10.4 pIC50 = 10.4 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 520 9 3 8 4.4 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)CO)c1 10.1016/j.bmcl.2004.01.008
CHEMBL289216 200471 0 None None None Human 10.4 pIC50 = 10.4 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 520 9 3 8 4.4 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)CO)c1 10.1016/j.bmcl.2004.01.008
9938571 23901 0 None None None Rat 10.4 pIC50 = 10.4 Binding
Ability to inhibit specific binding of [125I]- -ET-1 to rat A 10 cells which express endothelin A receptorAbility to inhibit specific binding of [125I]- -ET-1 to rat A 10 cells which express endothelin A receptor
ChEMBL 597 9 1 8 5.6 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm000538f
CHEMBL112531 23901 0 None None None Rat 10.4 pIC50 = 10.4 Binding
Ability to inhibit specific binding of [125I]- -ET-1 to rat A 10 cells which express endothelin A receptorAbility to inhibit specific binding of [125I]- -ET-1 to rat A 10 cells which express endothelin A receptor
ChEMBL 597 9 1 8 5.6 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm000538f
9938571 23901 0 None None None Rat 10.4 pIC50 = 10.4 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 597 9 1 8 5.6 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
CHEMBL112531 23901 0 None None None Rat 10.4 pIC50 = 10.4 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 597 9 1 8 5.6 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
10187997 219519 0 None None None Rat 10.4 pIC50 = 10.4 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 564 13 1 7 4.2 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm031041j
CHEMBL323464 219519 0 None None None Rat 10.4 pIC50 = 10.4 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 564 13 1 7 4.2 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm031041j
11828009 24194 0 None None None Pig 10.4 pIC50 = 10.4 Binding
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 581 11 2 10 4.7 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(CO)cc2)nc1 10.1021/jm000538f
CHEMBL114298 24194 0 None None None Pig 10.4 pIC50 = 10.4 Binding
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 581 11 2 10 4.7 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(CO)cc2)nc1 10.1021/jm000538f
11966523 219905 0 None None None Pig 10.4 pIC50 = 10.4 Binding
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 613 10 2 9 4.7 CC(C)(C)c1ccc(S(=O)(=O)Nc2ncnc(OCCOc3ncc(Br)cn3)c2-c2ccc(CO)cc2)cc1 10.1021/jm000538f
CHEMBL324184 219905 0 None None None Pig 10.4 pIC50 = 10.4 Binding
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 613 10 2 9 4.7 CC(C)(C)c1ccc(S(=O)(=O)Nc2ncnc(OCCOc3ncc(Br)cn3)c2-c2ccc(CO)cc2)cc1 10.1021/jm000538f
9934302 144857 1 None None None Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 467 6 2 7 4.6 CC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
CHEMBL19950 144857 1 None None None Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 467 6 2 7 4.6 CC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
11752337 317724 0 None None None Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 496 7 2 8 4.7 CO/N=C(\C)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
CHEMBL416324 317724 0 None None None Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 496 7 2 8 4.7 CO/N=C(\C)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
23445355 450423 0 None None None Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 469 6 2 8 3.8 COC(=O)c1cc(C)ccc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
CHEMBL60149 450423 0 None None None Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 469 6 2 8 3.8 COC(=O)c1cc(C)ccc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
9934302 144857 1 None None None Human 10.4 pIC50 = 10.4 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 467 6 2 7 4.6 CC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm000349x
CHEMBL19950 144857 1 None None None Human 10.4 pIC50 = 10.4 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 467 6 2 7 4.6 CC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm000349x
44284115 200365 0 None None None Human 10.4 pIC50 = 10.4 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 518 9 3 7 4.8 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)CO)c1 10.1016/j.bmcl.2004.01.008
CHEMBL288247 200365 0 None None None Human 10.4 pIC50 = 10.4 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 518 9 3 7 4.8 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)CO)c1 10.1016/j.bmcl.2004.01.008
44381125 122069 0 None None None Pig 10.4 pIC50 = 10.4 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 674 10 1 9 6.6 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)nc(-c3ccccn3)nc2OCCOc2ncc(Br)cn2)cc1 10.1016/s0960-894x(01)00682-5
CHEMBL170493 122069 0 None None None Pig 10.4 pIC50 = 10.4 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 674 10 1 9 6.6 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)nc(-c3ccccn3)nc2OCCOc2ncc(Br)cn2)cc1 10.1016/s0960-894x(01)00682-5
10187997 219519 0 None None None Human 10.4 pIC50 = 10.4 Binding
Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).
ChEMBL 564 13 1 7 4.2 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
CHEMBL323464 219519 0 None None None Human 10.4 pIC50 = 10.4 Binding
Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).
ChEMBL 564 13 1 7 4.2 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
44284287 316800 0 None None None Human 10.4 pIC50 = 10.4 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 532 10 3 7 5.2 CCC(CO)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
CHEMBL411925 316800 0 None None None Human 10.4 pIC50 = 10.4 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 532 10 3 7 5.2 CCC(CO)Cc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
CHEMBL437472 484344 0 None None None Human 10.3 pIC50 = 10.3 Binding
Inhibition of ETA receptor in human SK-N-MC cells after 60 mins by scintillation countingInhibition of ETA receptor in human SK-N-MC cells after 60 mins by scintillation counting
ChEMBL 2490 47 32 36 -4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/np900287e
44284328 255490 0 None None None Human 10.3 pIC50 = 10.3 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 476 7 2 7 4.6 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC)c1 10.1016/j.bmcl.2004.01.008
CHEMBL36627 255490 0 None None None Human 10.3 pIC50 = 10.3 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 476 7 2 7 4.6 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC)c1 10.1016/j.bmcl.2004.01.008
44284437 200163 0 None None None Human 10.3 pIC50 = 10.3 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 520 9 4 8 3.5 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(O)CO)c1 10.1016/j.bmcl.2004.01.008
CHEMBL286621 200163 0 None None None Human 10.3 pIC50 = 10.3 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 520 9 4 8 3.5 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(O)CO)c1 10.1016/j.bmcl.2004.01.008
44386450 125137 0 None None None Rat 10.3 pIC50 = 10.3 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 606 15 1 10 5.1 COC(=O)CCCCOc1cc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3c(c2)OCO3)cc(OC)c1OC 10.1021/jm031041j
CHEMBL177973 125137 0 None None None Rat 10.3 pIC50 = 10.3 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 606 15 1 10 5.1 COC(=O)CCCCOc1cc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3c(c2)OCO3)cc(OC)c1OC 10.1021/jm031041j
CHEMBL437472 484344 0 None None None Human 10.3 pIC50 = 10.3 Binding
Binding affinity to human ETA receptor by radioligand displacement assayBinding affinity to human ETA receptor by radioligand displacement assay
ChEMBL 2490 47 32 36 -4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/j.ejmech.2013.01.044
10143256 200725 0 None None None Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 531 7 2 8 4.6 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(S(=O)(=O)C(C)C)c1 10.1021/jm030528p
CHEMBL291592 200725 0 None None None Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 531 7 2 8 4.6 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(S(=O)(=O)C(C)C)c1 10.1021/jm030528p
10183338 467867 0 None None None Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 464 5 2 7 4.5 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C#N)c1C 10.1021/jm030528p
CHEMBL62159 467867 0 None None None Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 464 5 2 7 4.5 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C#N)c1C 10.1021/jm030528p
10722385 200653 0 None None None Human 10.3 pIC50 = 10.3 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 606 13 1 11 4.6 COC(=O)CCCCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC 10.1021/jm980504w
CHEMBL291058 200653 0 None None None Human 10.3 pIC50 = 10.3 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 606 13 1 11 4.6 COC(=O)CCCCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC 10.1021/jm980504w
11006709 24259 0 None None None Pig 10.3 pIC50 = 10.3 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membraneIn vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane
ChEMBL 629 11 1 10 5.4 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)c1 10.1016/s0960-894x(01)00682-5
CHEMBL114700 24259 0 None None None Pig 10.3 pIC50 = 10.3 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membraneIn vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane
ChEMBL 629 11 1 10 5.4 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)c1 10.1016/s0960-894x(01)00682-5
11006709 24259 0 None None None Pig 10.3 pIC50 = 10.3 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 629 11 1 10 5.4 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)c1 10.1021/jm0102304
CHEMBL114700 24259 0 None None None Pig 10.3 pIC50 = 10.3 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 629 11 1 10 5.4 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)c1 10.1021/jm0102304
10651488 328358 0 None None None Human 10.3 pIC50 = 10.3 Binding
Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).
ChEMBL 618 13 1 7 4.8 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F 10.1021/jm970101g
CHEMBL419367 328358 0 None None None Human 10.3 pIC50 = 10.3 Binding
Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).
ChEMBL 618 13 1 7 4.8 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F 10.1021/jm970101g
159594 1080 38 None None None Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membraneDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/acs.jmedchem.5b01781
3487 1080 38 None None None Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membraneDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/acs.jmedchem.5b01781
CHEMBL9194 1080 38 None None None Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membraneDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/acs.jmedchem.5b01781
DB06199 1080 38 None None None Human 10.3 pIC50 = 10.3 Binding
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membraneDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/acs.jmedchem.5b01781
44284041 200471 0 None None None Human 10.2 pIC50 = 10.2 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 520 9 3 8 4.4 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)CO)c1 10.1016/j.bmcl.2004.01.008
CHEMBL289216 200471 0 None None None Human 10.2 pIC50 = 10.2 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 520 9 3 8 4.4 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)CO)c1 10.1016/j.bmcl.2004.01.008
11734600 24312 0 None None None Pig 10.2 pIC50 = 10.2 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 585 11 1 10 5.3 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Cl)cn2)c1 10.1021/jm0102304
CHEMBL114964 24312 0 None None None Pig 10.2 pIC50 = 10.2 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 585 11 1 10 5.3 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Cl)cn2)c1 10.1021/jm0102304
44284115 200365 0 None None None Human 10.2 pIC50 = 10.2 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 518 9 3 7 4.8 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)CO)c1 10.1016/j.bmcl.2004.01.008
CHEMBL288247 200365 0 None None None Human 10.2 pIC50 = 10.2 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 518 9 3 7 4.8 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CC(C)CO)c1 10.1016/j.bmcl.2004.01.008
10119327 467838 0 None None None Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 531 8 2 8 4.6 CCCS(=O)(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
CHEMBL62019 467838 0 None None None Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 531 8 2 8 4.6 CCCS(=O)(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
10206155 467857 0 None None None Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 481 7 2 7 5.0 CCC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
CHEMBL62112 467857 0 None None None Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 481 7 2 7 5.0 CCC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
10344914 200311 0 None None None Human 10.2 pIC50 = 10.2 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 476 7 3 7 4.1 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CO)c1 10.1016/j.bmcl.2004.01.008
CHEMBL287711 200311 0 None None None Human 10.2 pIC50 = 10.2 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 476 7 3 7 4.1 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CO)c1 10.1016/j.bmcl.2004.01.008
44284391 276620 0 None None None Human 10.2 pIC50 = 10.2 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 532 9 3 7 5.3 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCC(C)(C)O)c1 10.1016/j.bmcl.2004.01.008
CHEMBL37920 276620 0 None None None Human 10.2 pIC50 = 10.2 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 532 9 3 7 5.3 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(CCC(C)(C)O)c1 10.1016/j.bmcl.2004.01.008
10119177 236310 0 None None None Rat 10.2 pIC50 = 10.2 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 528 12 1 6 4.8 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm010237l
CHEMBL339904 236310 0 None None None Rat 10.2 pIC50 = 10.2 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 528 12 1 6 4.8 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm010237l
10603409 220129 0 None None None Human 10.2 pIC50 = 10.2 Binding
Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).
ChEMBL 584 13 1 7 4.1 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl 10.1021/jm970101g
CHEMBL325581 220129 0 None None None Human 10.2 pIC50 = 10.2 Binding
Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).
ChEMBL 584 13 1 7 4.1 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl 10.1021/jm970101g
10228588 201965 0 None None None Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 496 6 2 7 4.1 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)N(C)C)c1 10.1021/jm030528p
CHEMBL300577 201965 0 None None None Human 10.2 pIC50 = 10.2 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 496 6 2 7 4.1 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)N(C)C)c1 10.1021/jm030528p
10210629 23076 0 None None None Human 10.1 pIC50 = 10.1 Binding
Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).
ChEMBL 592 15 1 7 5.0 CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
CHEMBL109644 23076 0 None None None Human 10.1 pIC50 = 10.1 Binding
Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).
ChEMBL 592 15 1 7 5.0 CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
14516 397 1 None None None Human 10.1 pIC50 = 10.1 Binding
Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1021/jm970101g
9916235 397 1 None None None Human 10.1 pIC50 = 10.1 Binding
Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1021/jm970101g
CHEMBL111277 397 1 None None None Human 10.1 pIC50 = 10.1 Binding
Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).Binding assay performed using human Endothelin A receptor (hETA) expressed in chinese hamster ovary cells(CHO).
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1021/jm970101g
14516 397 1 None None None Human 10.1 pIC50 = 10.1 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1021/jm990170q
9916235 397 1 None None None Human 10.1 pIC50 = 10.1 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1021/jm990170q
CHEMBL111277 397 1 None None None Human 10.1 pIC50 = 10.1 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1021/jm990170q
159594 1080 38 None None None Human 10.1 pIC50 = 10.1 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm990170q
3487 1080 38 None None None Human 10.1 pIC50 = 10.1 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm990170q
CHEMBL9194 1080 38 None None None Human 10.1 pIC50 = 10.1 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm990170q
DB06199 1080 38 None None None Human 10.1 pIC50 = 10.1 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm990170q
10278217 201881 0 None None None Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 492 6 2 8 5.0 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(-c2ncco2)c1 10.1021/jm030528p
CHEMBL299921 201881 0 None None None Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 492 6 2 8 5.0 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(-c2ncco2)c1 10.1021/jm030528p
9911482 332806 21 None None None Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 447 6 2 7 4.2 CC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm030528p
CHEMBL432521 332806 21 None None None Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 447 6 2 7 4.2 CC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm030528p
DB05407 332806 21 None None None Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 447 6 2 7 4.2 CC(=O)c1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm030528p
10114414 414014 0 None None None Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 444 5 2 7 4.2 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C#N)c1C 10.1021/jm030528p
CHEMBL58359 414014 0 None None None Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 444 5 2 7 4.2 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C#N)c1C 10.1021/jm030528p
11766844 219339 0 None None None Rat 10.1 pIC50 = 10.1 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 553 9 1 8 5.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Cl)cn2)cc1 10.1021/jm0102304
CHEMBL323243 219339 0 None None None Rat 10.1 pIC50 = 10.1 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 553 9 1 8 5.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(Cl)cn2)cc1 10.1021/jm0102304
159594 1080 38 None None None Rat 10.1 pIC50 = 10.1 Binding
Inhibitory activity against human Endothelin A receptorInhibitory activity against human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
3487 1080 38 None None None Rat 10.1 pIC50 = 10.1 Binding
Inhibitory activity against human Endothelin A receptorInhibitory activity against human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
CHEMBL9194 1080 38 None None None Rat 10.1 pIC50 = 10.1 Binding
Inhibitory activity against human Endothelin A receptorInhibitory activity against human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
DB06199 1080 38 None None None Rat 10.1 pIC50 = 10.1 Binding
Inhibitory activity against human Endothelin A receptorInhibitory activity against human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
10115469 200981 0 None None None Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 459 5 2 6 5.0 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(Cl)c1 10.1021/jm030528p
CHEMBL293398 200981 0 None None None Human 10.1 pIC50 = 10.1 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 459 5 2 6 5.0 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(Cl)c1 10.1021/jm030528p
10627272 469007 0 None None None Human 10.1 pIC50 = 10.1 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 592 12 1 11 4.2 COC(=O)CCCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC 10.1021/jm980504w
CHEMBL69986 469007 0 None None None Human 10.1 pIC50 = 10.1 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 592 12 1 11 4.2 COC(=O)CCCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC 10.1021/jm980504w
10603409 220129 0 None None None Rat 10.0 pIC50 = 10.0 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 584 13 1 7 4.1 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl 10.1021/jm970101g
CHEMBL325581 220129 0 None None None Rat 10.0 pIC50 = 10.0 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 584 13 1 7 4.1 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl 10.1021/jm970101g
10187997 219519 0 None None None Rat 10.0 pIC50 = 10 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 564 13 1 7 4.2 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
CHEMBL323464 219519 0 None None None Rat 10.0 pIC50 = 10 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 564 13 1 7 4.2 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
21041278 336308 0 None None None Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 554 12 2 9 3.5 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4467748 336308 0 None None None Human 10.0 pIC50 = 10 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 554 12 2 9 3.5 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
10165963 202905 0 None None None Human 10.0 pIC50 = 10 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 545 8 2 9 3.6 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)CS(C)(=O)=O)c1 10.1021/jm030528p
CHEMBL305602 202905 0 None None None Human 10.0 pIC50 = 10 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 545 8 2 9 3.6 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)CS(C)(=O)=O)c1 10.1021/jm030528p
10366278 336984 0 None None None Human 10.0 pIC50 = 10 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 446 6 2 6 4.6 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
CHEMBL448165 336984 0 None None None Human 10.0 pIC50 = 10 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 446 6 2 6 4.6 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
10624511 143965 0 None None None Human 10.0 pIC50 = 10 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 478 6 2 7 4.7 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2noc(C)c2Cl)c(C)c1CC#N 10.1021/jm000349x
CHEMBL19661 143965 0 None None None Human 10.0 pIC50 = 10 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 478 6 2 7 4.7 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2noc(C)c2Cl)c(C)c1CC#N 10.1021/jm000349x
10210629 23076 0 None None None Rat 10.0 pIC50 = 10.0 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 592 15 1 7 5.0 CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
CHEMBL109644 23076 0 None None None Rat 10.0 pIC50 = 10.0 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 592 15 1 7 5.0 CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
11827657 43236 0 None None None Rat 10.0 pIC50 = 10.0 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 540 13 1 7 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(OC)c1 10.1021/jm010237l
CHEMBL129220 43236 0 None None None Rat 10.0 pIC50 = 10.0 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 540 13 1 7 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(OC)c1 10.1021/jm010237l
CHEMBL437472 484344 0 None None None Human 10.0 pIC50 = 10.0 Binding
Binding affinity to human ETA receptor by radioligand displacement assayBinding affinity to human ETA receptor by radioligand displacement assay
ChEMBL 2490 47 32 36 -4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/j.bmc.2013.03.016
44302615 447296 0 None None None Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 497 7 2 8 4.6 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)OC(C)C)c1 10.1021/jm030528p
CHEMBL59819 447296 0 None None None Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 497 7 2 8 4.6 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)OC(C)C)c1 10.1021/jm030528p
25211074 42345 0 None None None Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 543 10 2 7 5.1 CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1272244 42345 0 None None None Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 543 10 2 7 5.1 CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2010.08.074
11016761 218606 0 None None None Pig 10.0 pIC50 = 10.0 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 519 9 1 8 4.8 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncccn2)cc1 10.1021/jm0102304
CHEMBL321242 218606 0 None None None Pig 10.0 pIC50 = 10.0 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 519 9 1 8 4.8 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncccn2)cc1 10.1021/jm0102304
44284329 200572 0 None None None Human 10.0 pIC50 = 10.0 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 504 8 2 7 5.4 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)C)c1 10.1016/j.bmcl.2004.01.008
CHEMBL290181 200572 0 None None None Human 10.0 pIC50 = 10.0 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 504 8 2 7 5.4 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OC(C)C)c1 10.1016/j.bmcl.2004.01.008
9914310 473055 10 None None None Human 10.0 pIC50 = 10.0 Binding
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL8923 473055 10 None None None Human 10.0 pIC50 = 10.0 Binding
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 10.1021/jm9505369
10768977 124601 0 None None None Rat 9.9 pIC50 = 9.9 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 548 13 1 8 5.6 CCOc1cc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3c(c2)OCO3)cc(OCC)c1OCC 10.1021/jm031041j
CHEMBL177378 124601 0 None None None Rat 9.9 pIC50 = 9.9 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 548 13 1 8 5.6 CCOc1cc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3c(c2)OCO3)cc(OCC)c1OCC 10.1021/jm031041j
44352079 235452 0 None None None Rat 9.9 pIC50 = 9.9 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 494 11 1 5 5.0 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)cc1 10.1021/jm010237l
CHEMBL336272 235452 0 None None None Rat 9.9 pIC50 = 9.9 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 494 11 1 5 5.0 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)cc1 10.1021/jm010237l
10674176 318183 0 None None None Human 9.9 pIC50 = 9.9 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 548 11 1 9 5.0 CCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OCC)c1OCC 10.1021/jm9606507
CHEMBL417067 318183 0 None None None Human 9.9 pIC50 = 9.9 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 548 11 1 9 5.0 CCOc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OCC)c1OCC 10.1021/jm9606507
44334146 332745 0 None None None Human 9.9 pIC50 = 9.9 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 446 7 2 6 4.6 CCCNc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
CHEMBL432012 332745 0 None None None Human 9.9 pIC50 = 9.9 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 446 7 2 6 4.6 CCCNc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
10163744 198964 0 None None None Human 9.9 pIC50 = 9.9 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 495 7 2 7 5.2 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)C(C)C)c1 10.1021/jm000349x
CHEMBL277706 198964 0 None None None Human 9.9 pIC50 = 9.9 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 495 7 2 7 5.2 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)C(C)C)c1 10.1021/jm000349x
14516 397 1 None None None Rat 9.9 pIC50 = 9.9 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1021/jm970101g
9916235 397 1 None None None Rat 9.9 pIC50 = 9.9 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1021/jm970101g
CHEMBL111277 397 1 None None None Rat 9.9 pIC50 = 9.9 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1021/jm970101g
11465535 451603 0 None None None Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 468 6 3 7 3.5 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(N)=O)c1 10.1021/jm030528p
CHEMBL60276 451603 0 None None None Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 468 6 3 7 3.5 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(N)=O)c1 10.1021/jm030528p
10277399 139153 0 None None None Human 9.9 pIC50 = 9.9 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 478 6 2 7 4.7 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1CC#N 10.1021/jm000349x
CHEMBL18626 139153 0 None None None Human 9.9 pIC50 = 9.9 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 478 6 2 7 4.7 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1CC#N 10.1021/jm000349x
10139080 144780 0 None None None Human 9.9 pIC50 = 9.9 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 454 6 2 7 4.6 Cc1cc(C)c(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1O 10.1021/jm000349x
CHEMBL19921 144780 0 None None None Human 9.9 pIC50 = 9.9 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 454 6 2 7 4.6 Cc1cc(C)c(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1O 10.1021/jm000349x
10717923 198946 0 None None None Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 439 5 2 6 4.7 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1021/jm030528p
CHEMBL277595 198946 0 None None None Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 439 5 2 6 4.7 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1021/jm030528p
9810351 120873 0 None None None Pig 9.8 pIC50 = 9.8 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 705 14 2 12 5.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(SCCO)nc1OCCOc1ncc(Br)cn1 10.1016/s0960-894x(01)00682-5
CHEMBL167314 120873 0 None None None Pig 9.8 pIC50 = 9.8 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 705 14 2 12 5.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(SCCO)nc1OCCOc1ncc(Br)cn1 10.1016/s0960-894x(01)00682-5
CHEMBL437472 484344 0 None None None Pig 9.8 pIC50 = 9.8 Binding
Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorTested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptor
ChEMBL 2490 47 32 36 -4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00077a013
9936145 42882 2 None None None Human 9.8 pIC50 = 9.8 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 510 11 1 4 5.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)c(F)c1 10.1021/jm010237l
CHEMBL128818 42882 2 None None None Human 9.8 pIC50 = 9.8 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 510 11 1 4 5.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)c(F)c1 10.1021/jm010237l
CHEMBL437472 484344 0 None None None Human 9.8 pIC50 = 9.8 Binding
Displacement of radiolabeled endothelin-1 from human endothelin ETA receptorDisplacement of radiolabeled endothelin-1 from human endothelin ETA receptor
ChEMBL 2490 47 32 36 -4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm8007618
11731472 23816 0 None None None Pig 9.8 pIC50 = 9.8 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 571 10 1 10 5.6 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)s2)nc1 10.1021/jm0102304
CHEMBL112141 23816 0 None None None Pig 9.8 pIC50 = 9.8 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 571 10 1 10 5.6 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)s2)nc1 10.1021/jm0102304
11050163 26019 0 None None None Pig 9.8 pIC50 = 9.8 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 583 10 1 8 5.4 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
CHEMBL1181553 26019 0 None None None Pig 9.8 pIC50 = 9.8 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 583 10 1 8 5.4 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)C)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
44351968 236907 0 None None None Rat 9.8 pIC50 = 9.8 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 508 12 1 5 5.2 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)cc1 10.1021/jm010237l
CHEMBL340575 236907 0 None None None Rat 9.8 pIC50 = 9.8 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 508 12 1 5 5.2 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)cc1 10.1021/jm010237l
10717923 198946 0 None None None Human 9.8 pIC50 = 9.8 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 439 5 2 6 4.7 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1021/jm000349x
CHEMBL277595 198946 0 None None None Human 9.8 pIC50 = 9.8 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 439 5 2 6 4.7 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1021/jm000349x
10623757 199166 0 None None None Human 9.8 pIC50 = 9.8 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 458 6 2 7 4.4 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1CC#N 10.1021/jm000349x
CHEMBL279471 199166 0 None None None Human 9.8 pIC50 = 9.8 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 458 6 2 7 4.4 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1CC#N 10.1021/jm000349x
9806559 23455 0 None None None Human 9.8 pIC50 = 9.8 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 515 13 1 6 3.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCC1=O 10.1021/jm980217s
CHEMBL110053 23455 0 None None None Human 9.8 pIC50 = 9.8 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 515 13 1 6 3.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCC1=O 10.1021/jm980217s
9936145 42882 2 None None None Human 9.7 pIC50 = 9.7 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 510 11 1 4 5.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)c(F)c1 10.1021/jm010237l
CHEMBL128818 42882 2 None None None Human 9.7 pIC50 = 9.7 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 510 11 1 4 5.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)c(F)c1 10.1021/jm010237l
CHEMBL1790959 484817 0 None None None Pig 9.7 pIC50 = 9.7 Binding
Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorTested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptor
ChEMBL 2462 45 32 36 -5.2 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00077a013
9825494 461602 0 None None None Rat 9.7 pIC50 = 9.7 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm031041j
CHEMBL61211 461602 0 None None None Rat 9.7 pIC50 = 9.7 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm031041j
9825494 461602 0 None None None Rat 9.7 pIC50 = 9.7 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL61211 461602 0 None None None Rat 9.7 pIC50 = 9.7 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
9825494 461602 0 None None None Rat 9.7 pIC50 = 9.7 Binding
Displacement of [125I]ET-1 from ET-A receptor in RASMC incubated for 60 minsDisplacement of [125I]ET-1 from ET-A receptor in RASMC incubated for 60 mins
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/acs.jmedchem.5b01781
CHEMBL61211 461602 0 None None None Rat 9.7 pIC50 = 9.7 Binding
Displacement of [125I]ET-1 from ET-A receptor in RASMC incubated for 60 minsDisplacement of [125I]ET-1 from ET-A receptor in RASMC incubated for 60 mins
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/acs.jmedchem.5b01781
9868637 199314 1 None None None Human 9.7 pIC50 = 9.7 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 455 5 3 7 4.4 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1O 10.1021/jm000349x
CHEMBL280659 199314 1 None None None Human 9.7 pIC50 = 9.7 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 455 5 3 7 4.4 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1O 10.1021/jm000349x
CHEMBL1790963 484820 0 None None None Pig 9.7 pIC50 = 9.7 Binding
Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorTested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptor
ChEMBL 2476 46 32 36 -4.8 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00077a013
11757759 348496 0 None None None Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 570 13 2 10 2.8 COCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4553625 348496 0 None None None Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 570 13 2 10 2.8 COCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
18931096 121534 0 None None None Pig 9.7 pIC50 = 9.7 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 689 14 2 12 4.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(OCCO)nc1OCCOc1ncc(Br)cn1 10.1016/s0960-894x(01)00682-5
CHEMBL168604 121534 0 None None None Pig 9.7 pIC50 = 9.7 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 689 14 2 12 4.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(OCCO)nc1OCCOc1ncc(Br)cn1 10.1016/s0960-894x(01)00682-5
CHEMBL437472 484344 0 None None None Human 9.7 pIC50 = 9.7 Binding
Inhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cellsInhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cells
ChEMBL 2490 47 32 36 -4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00095a029
10722371 202317 0 None None None Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 605 11 1 11 3.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCN3CCOCC3)c2)cc1 10.1021/jm980504w
CHEMBL302974 202317 0 None None None Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 605 11 1 11 3.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCN3CCOCC3)c2)cc1 10.1021/jm980504w
10578853 213319 0 None None None Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 564 10 1 11 3.4 COC(=O)COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC 10.1021/jm980504w
CHEMBL308646 213319 0 None None None Human 9.7 pIC50 = 9.7 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 564 10 1 11 3.4 COC(=O)COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc(OC)c1OC 10.1021/jm980504w
44334128 18754 0 None None None Human 9.7 pIC50 = 9.7 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 443 7 1 5 4.9 C=CCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
CHEMBL101424 18754 0 None None None Human 9.7 pIC50 = 9.7 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 443 7 1 5 4.9 C=CCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
9939238 469068 0 None None None Human 9.7 pIC50 = 9.7 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 637 12 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70385 469068 0 None None None Human 9.7 pIC50 = 9.7 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 637 12 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL437472 484344 0 None None None Human 9.7 pIC50 = 9.7 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 2490 47 32 36 -4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(97)00400-9
CHEMBL1790960 484818 0 None None None Pig 9.7 pIC50 = 9.7 Binding
Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorTested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptor
ChEMBL 2462 46 32 36 -5.1 CCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00077a013
10120499 219315 0 None None None Rat 9.7 pIC50 = 9.7 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 564 12 1 7 4.1 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CC(C)C 10.1021/jm970101g
CHEMBL323055 219315 0 None None None Rat 9.7 pIC50 = 9.7 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 564 12 1 7 4.1 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CC(C)C 10.1021/jm970101g
11113541 468300 0 None None None Rat 9.7 pIC50 = 9.7 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 476 7 1 7 5.2 COc1ccc(OC2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL64632 468300 0 None None None Rat 9.7 pIC50 = 9.7 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 476 7 1 7 5.2 COc1ccc(OC2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
10299555 201171 0 None None None Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 481 6 2 7 4.9 CC(=O)c1cc(C)cc(C)c1NC(=O)c1sc(C)cc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
CHEMBL294563 201171 0 None None None Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 481 6 2 7 4.9 CC(=O)c1cc(C)cc(C)c1NC(=O)c1sc(C)cc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
10321290 18980 0 None None None Human 9.7 pIC50 = 9.7 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 445 7 1 5 5.1 CCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
CHEMBL102969 18980 0 None None None Human 9.7 pIC50 = 9.7 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 445 7 1 5 5.1 CCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
10651488 328358 0 None None None Rat 9.7 pIC50 = 9.7 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 618 13 1 7 4.8 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F 10.1021/jm970101g
CHEMBL419367 328358 0 None None None Rat 9.7 pIC50 = 9.7 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 618 13 1 7 4.8 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F 10.1021/jm970101g
44284381 256449 0 None None None Human 9.7 pIC50 = 9.7 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 462 6 3 7 4.3 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(O)c1 10.1016/j.bmcl.2004.01.008
CHEMBL36671 256449 0 None None None Human 9.7 pIC50 = 9.7 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 462 6 3 7 4.3 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(O)c1 10.1016/j.bmcl.2004.01.008
10648937 474209 0 None None None Rat 9.7 pIC50 = 9.7 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 496 11 1 6 4.3 CCCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9334 474209 0 None None None Rat 9.7 pIC50 = 9.7 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 496 11 1 6 4.3 CCCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL437472 484344 0 None None None Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]Endothelin-1 from human recombinant ETA receptor expressed in CHOK1 cells after 2 hrsDisplacement of [125I]Endothelin-1 from human recombinant ETA receptor expressed in CHOK1 cells after 2 hrs
ChEMBL 2490 47 32 36 -4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/j.bmcl.2013.01.025
123883 38550 0 None None None Human 9.6 pIC50 = 9.6 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 927 12 9 11 0.8 CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm970101g
15515963 38550 0 None None None Human 9.6 pIC50 = 9.6 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 927 12 9 11 0.8 CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm970101g
CHEMBL1205177 38550 0 None None None Human 9.6 pIC50 = 9.6 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 927 12 9 11 0.8 CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm970101g
CHEMBL6070927 38550 0 None None None Human 9.6 pIC50 = 9.6 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 927 12 9 11 0.8 CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm970101g
123883 38550 0 None None None Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 927 12 9 11 0.8 CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm030528p
15515963 38550 0 None None None Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 927 12 9 11 0.8 CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm030528p
CHEMBL1205177 38550 0 None None None Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 927 12 9 11 0.8 CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm030528p
CHEMBL6070927 38550 0 None None None Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 927 12 9 11 0.8 CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm030528p
11006532 26513 0 None None None Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 601 10 1 9 6.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3cccs3)cn2)cc1 10.1021/jm0102304
CHEMBL1184515 26513 0 None None None Rat 9.6 pIC50 = 9.6 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 601 10 1 9 6.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3cccs3)cn2)cc1 10.1021/jm0102304
9894460 473657 11 None None None Human 9.6 pIC50 = 9.6 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1021/jm970101g
CHEMBL8978 473657 11 None None None Human 9.6 pIC50 = 9.6 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1021/jm970101g
22004774 200953 0 None None None Rat 9.6 pIC50 = 9.6 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 442 8 1 6 5.7 CCCCSC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL293192 200953 0 None None None Rat 9.6 pIC50 = 9.6 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 442 8 1 6 5.7 CCCCSC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL2304284 485330 0 None None None Human 9.5 pIC50 = 9.5 Binding
Inhibition of ETA receptor in human SK-N-MC cells after 60 mins by scintillation countingInhibition of ETA receptor in human SK-N-MC cells after 60 mins by scintillation counting
ChEMBL 2531 45 33 35 -4.1 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/np900287e
44387242 239056 0 None None None Rat 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 502 15 1 5 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCCC(C)C 10.1021/jm031041j
CHEMBL353560 239056 0 None None None Rat 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 502 15 1 5 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCCC(C)C 10.1021/jm031041j
11093237 24694 0 None None None Pig 9.5 pIC50 = 9.5 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 601 10 1 9 6.4 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc3ccccc3c2)nc1 10.1021/jm0102304
CHEMBL116281 24694 0 None None None Pig 9.5 pIC50 = 9.5 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 601 10 1 9 6.4 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc3ccccc3c2)nc1 10.1021/jm0102304
10769526 202760 0 None None None Human 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 578 12 2 10 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCC(=O)O)c2)cc1 10.1021/jm980504w
CHEMBL304762 202760 0 None None None Human 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 578 12 2 10 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCC(=O)O)c2)cc1 10.1021/jm980504w
9870959 23227 0 None None None Human 9.5 pIC50 = 9.5 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 509 13 1 6 4.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 10.1021/jm980217s
CHEMBL109778 23227 0 None None None Human 9.5 pIC50 = 9.5 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 509 13 1 6 4.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 10.1021/jm980217s
44339655 23411 0 None None None Human 9.5 pIC50 = 9.5 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 530 14 1 6 5.3 C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2cc(OC)c3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
CHEMBL109926 23411 0 None None None Human 9.5 pIC50 = 9.5 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 530 14 1 6 5.3 C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2cc(OC)c3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
10278777 332860 0 None None None Human 9.5 pIC50 = 9.5 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 502 14 1 5 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
CHEMBL432974 332860 0 None None None Human 9.5 pIC50 = 9.5 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 502 14 1 5 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
9870830 473662 29 None None None Human 9.5 pIC50 = 9.5 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
CHEMBL8981 473662 29 None None None Human 9.5 pIC50 = 9.5 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
9939238 469068 0 None None None Human 9.5 pIC50 = 9.5 Binding
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 637 12 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/j.bmcl.2016.06.014
CHEMBL70385 469068 0 None None None Human 9.5 pIC50 = 9.5 Binding
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 637 12 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/j.bmcl.2016.06.014
21041284 335481 0 None None None Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 568 13 2 9 3.9 CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4455360 335481 0 None None None Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 568 13 2 9 3.9 CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
58688006 335657 0 None None None Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 524 13 2 9 3.8 CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4458005 335657 0 None None None Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 524 13 2 9 3.8 CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
9870830 473662 29 None None None Mouse 9.5 pIC50 = 9.5 Binding
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/j.bmc.2009.08.058
CHEMBL8981 473662 29 None None None Mouse 9.5 pIC50 = 9.5 Binding
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/j.bmc.2009.08.058
21041264 163438 2 None None None Human 9.5 pIC50 = 9.5 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 600 12 2 8 4.0 CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
CHEMBL2165339 163438 2 None None None Human 9.5 pIC50 = 9.5 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 600 12 2 8 4.0 CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
10311570 38536 0 None None None Rat 9.5 pIC50 = 9.5 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 520 10 1 9 4.7 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1205068 38536 0 None None None Rat 9.5 pIC50 = 9.5 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 520 10 1 9 4.7 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
10555424 468990 0 None None None Human 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 592 13 2 10 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCCC(=O)O)c2)cc1 10.1021/jm980504w
CHEMBL69832 468990 0 None None None Human 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 592 13 2 10 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCCC(=O)O)c2)cc1 10.1021/jm980504w
9870830 473662 29 None None None Human 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm980504w
CHEMBL8981 473662 29 None None None Human 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm980504w
9871348 468982 0 None None None Rat 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 520 8 1 10 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4nsnc4c3)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/s0960-894x(97)10151-2
CHEMBL69741 468982 0 None None None Rat 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 520 8 1 10 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4nsnc4c3)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/s0960-894x(97)10151-2
9809919 469315 0 None None None Human 9.5 pIC50 = 9.5 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 665 13 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL72037 469315 0 None None None Human 9.5 pIC50 = 9.5 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 665 13 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL437472 484344 0 None None None Human 9.5 pIC50 = 9.5 Binding
Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cellsReceptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cells
ChEMBL 2490 47 32 36 -4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(97)00400-9
159594 1080 38 None None None Rat 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm031041j
3487 1080 38 None None None Rat 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm031041j
CHEMBL9194 1080 38 None None None Rat 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm031041j
DB06199 1080 38 None None None Rat 9.5 pIC50 = 9.5 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm031041j
159594 1080 38 None None None Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm030528p
3487 1080 38 None None None Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm030528p
CHEMBL9194 1080 38 None None None Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm030528p
DB06199 1080 38 None None None Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm030528p
159594 1080 38 None None None Rat 9.5 pIC50 = 9.5 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm9505369
3487 1080 38 None None None Rat 9.5 pIC50 = 9.5 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm9505369
CHEMBL9194 1080 38 None None None Rat 9.5 pIC50 = 9.5 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm9505369
DB06199 1080 38 None None None Rat 9.5 pIC50 = 9.5 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm9505369
11144344 468064 0 None None None Rat 9.5 pIC50 = 9.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 424 8 1 5 5.8 CCCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL63267 468064 0 None None None Rat 9.5 pIC50 = 9.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 424 8 1 5 5.8 CCCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
44334150 18880 0 None None None Human 9.5 pIC50 = 9.5 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 445 6 1 5 5.0 COc1ccc([C@@H]2c3nc(CC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
CHEMBL102314 18880 0 None None None Human 9.5 pIC50 = 9.5 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 445 6 1 5 5.0 COc1ccc([C@@H]2c3nc(CC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
9852318 23918 9 None None None Rat 9.5 pIC50 = 9.5 Binding
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm000538f
CHEMBL112624 23918 9 None None None Rat 9.5 pIC50 = 9.5 Binding
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm000538f
11102201 468258 0 None None None Rat 9.5 pIC50 = 9.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 438 9 1 6 5.1 C=CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL64447 468258 0 None None None Rat 9.5 pIC50 = 9.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 438 9 1 6 5.1 C=CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
44266903 38492 0 None None None Human 9.5 pIC50 = 9.5 Binding
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 536 11 1 9 4.4 COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL1204672 38492 0 None None None Human 9.5 pIC50 = 9.5 Binding
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 536 11 1 9 4.4 COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm9606507
9960931 217644 0 None None None Human 9.5 pIC50 = 9.5 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 635 12 1 12 4.1 CCOC(=O)CNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 10.1016/S0960-894X(97)00002-4
CHEMBL319452 217644 0 None None None Human 9.5 pIC50 = 9.5 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 635 12 1 12 4.1 CCOC(=O)CNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 10.1016/S0960-894X(97)00002-4
159594 1080 38 None None None Rat 9.4 pIC50 = 9.4 Binding
Binding affinity against Endothelin A receptor in MMQ cells in ratBinding affinity against Endothelin A receptor in MMQ cells in rat
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
3487 1080 38 None None None Rat 9.4 pIC50 = 9.4 Binding
Binding affinity against Endothelin A receptor in MMQ cells in ratBinding affinity against Endothelin A receptor in MMQ cells in rat
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
CHEMBL9194 1080 38 None None None Rat 9.4 pIC50 = 9.4 Binding
Binding affinity against Endothelin A receptor in MMQ cells in ratBinding affinity against Endothelin A receptor in MMQ cells in rat
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
DB06199 1080 38 None None None Rat 9.4 pIC50 = 9.4 Binding
Binding affinity against Endothelin A receptor in MMQ cells in ratBinding affinity against Endothelin A receptor in MMQ cells in rat
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
9914310 473055 10 None None None Rat 9.4 pIC50 = 9.4 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL8923 473055 10 None None None Rat 9.4 pIC50 = 9.4 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 10.1021/jm9505369
9870830 473662 29 None None None Human 9.4 pIC50 = 9.4 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/S0960-894X(97)00002-4
CHEMBL8981 473662 29 None None None Human 9.4 pIC50 = 9.4 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/S0960-894X(97)00002-4
11017436 24252 0 None None None Pig 9.4 pIC50 = 9.4 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 597 12 1 11 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCOc1ncc(SC)cn1 10.1021/jm0102304
CHEMBL114660 24252 0 None None None Pig 9.4 pIC50 = 9.4 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 597 12 1 11 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCOc1ncc(SC)cn1 10.1021/jm0102304
44333913 19440 0 None None None Human 9.4 pIC50 = 9.4 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 431 6 1 5 4.8 CCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
CHEMBL105591 19440 0 None None None Human 9.4 pIC50 = 9.4 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 431 6 1 5 4.8 CCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
9870959 23227 0 None None None Rat 9.4 pIC50 = 9.4 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 509 13 1 6 4.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 10.1021/jm980217s
CHEMBL109778 23227 0 None None None Rat 9.4 pIC50 = 9.4 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 509 13 1 6 4.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 10.1021/jm980217s
9809526 38759 0 None None None Human 9.4 pIC50 = 9.4 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 614 12 2 11 3.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCS(=O)(=O)O)c2)cc1 10.1021/jm980504w
CHEMBL1207463 38759 0 None None None Human 9.4 pIC50 = 9.4 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 614 12 2 11 3.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCS(=O)(=O)O)c2)cc1 10.1021/jm980504w
CHEMBL437472 484344 0 None None None Human 9.4 pIC50 = 9.4 Binding
Inhibition of human ETA receptorInhibition of human ETA receptor
ChEMBL 2490 47 32 36 -4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm701575k
10208674 201960 0 None None None Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 529 7 2 7 5.6 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)c2ccccc2)c1 10.1021/jm030528p
CHEMBL300547 201960 0 None None None Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 529 7 2 7 5.6 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)c2ccccc2)c1 10.1021/jm030528p
10603409 220129 0 None None None Rat 9.4 pIC50 = 9.4 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 584 13 1 7 4.1 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl 10.1021/jm970101g
CHEMBL325581 220129 0 None None None Rat 9.4 pIC50 = 9.4 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 584 13 1 7 4.1 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCCl 10.1021/jm970101g
9852318 23918 9 None None None Human 9.4 pIC50 = 9.4 Binding
Antagonist activity at ET-A receptor (unknown origin)Antagonist activity at ET-A receptor (unknown origin)
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/acs.jmedchem.5b01781
CHEMBL112624 23918 9 None None None Human 9.4 pIC50 = 9.4 Binding
Antagonist activity at ET-A receptor (unknown origin)Antagonist activity at ET-A receptor (unknown origin)
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/acs.jmedchem.5b01781
44332735 346837 0 None None None Human 9.4 pIC50 = 9.4 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 649 13 1 12 4.5 CCOC(=O)CCNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 10.1016/S0960-894X(97)00002-4
CHEMBL450337 346837 0 None None None Human 9.4 pIC50 = 9.4 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 649 13 1 12 4.5 CCOC(=O)CCNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 10.1016/S0960-894X(97)00002-4
159594 1080 38 None None None Rat 9.4 pIC50 = 9.4 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm960077r
3487 1080 38 None None None Rat 9.4 pIC50 = 9.4 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm960077r
CHEMBL9194 1080 38 None None None Rat 9.4 pIC50 = 9.4 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm960077r
DB06199 1080 38 None None None Rat 9.4 pIC50 = 9.4 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm960077r
9852318 23918 9 None None None Human 9.4 pIC50 = 9.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm3009103
CHEMBL112624 23918 9 None None None Human 9.4 pIC50 = 9.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm3009103
71462245 163095 0 None None None Human 9.4 pIC50 = 9.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 588 13 2 10 3.6 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1cc(OC)ccc1Cl 10.1021/jm3009103
CHEMBL2163692 163095 0 None None None Human 9.4 pIC50 = 9.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 588 13 2 10 3.6 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1cc(OC)ccc1Cl 10.1021/jm3009103
44386169 259273 0 None None None Human 9.4 pIC50 = 9.4 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 690 12 2 14 3.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
CHEMBL368996 259273 0 None None None Human 9.4 pIC50 = 9.4 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 690 12 2 14 3.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
11122784 327945 0 None None None Rat 9.4 pIC50 = 9.4 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 8 1 6 4.9 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL417413 327945 0 None None None Rat 9.4 pIC50 = 9.4 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 8 1 6 4.9 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
44339655 23411 0 None None None Rat 9.4 pIC50 = 9.4 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 530 14 1 6 5.3 C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2cc(OC)c3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
CHEMBL109926 23411 0 None None None Rat 9.4 pIC50 = 9.4 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 530 14 1 6 5.3 C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2cc(OC)c3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
44284196 200677 0 None None None Human 9.4 pIC50 = 9.4 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 504 9 2 7 5.4 CCCOc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
CHEMBL291247 200677 0 None None None Human 9.4 pIC50 = 9.4 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 504 9 2 7 5.4 CCCOc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
10364227 467879 0 None None None Rat 9.4 pIC50 = 9.4 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 410 7 1 5 5.4 CCCCC1=C(C(=O)O)[C@@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm031041j
CHEMBL62264 467879 0 None None None Rat 9.4 pIC50 = 9.4 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 410 7 1 5 5.4 CCCCC1=C(C(=O)O)[C@@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm031041j
10364227 467879 0 None None None Rat 9.4 pIC50 = 9.4 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 410 7 1 5 5.4 CCCCC1=C(C(=O)O)[C@@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL62264 467879 0 None None None Rat 9.4 pIC50 = 9.4 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 410 7 1 5 5.4 CCCCC1=C(C(=O)O)[C@@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
9806559 23455 0 None None None Rat 9.4 pIC50 = 9.4 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 515 13 1 6 3.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCC1=O 10.1021/jm980217s
CHEMBL110053 23455 0 None None None Rat 9.4 pIC50 = 9.4 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 515 13 1 6 3.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCC1=O 10.1021/jm980217s
11827880 24524 0 None None None Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 565 10 1 9 5.5 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)cc2)nc1 10.1021/jm0102304
CHEMBL116046 24524 0 None None None Rat 9.4 pIC50 = 9.4 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 565 10 1 9 5.5 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)cc2)nc1 10.1021/jm0102304
CHEMBL1790962 484819 0 None None None Pig 9.4 pIC50 = 9.4 Binding
Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorTested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptor
ChEMBL 2476 46 32 36 -4.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00077a013
10303555 328360 0 None None None Rat 9.4 pIC50 = 9.4 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 574 15 1 7 4.9 CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm970101g
CHEMBL419383 328360 0 None None None Rat 9.4 pIC50 = 9.4 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 574 15 1 7 4.9 CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm970101g
10578320 197620 0 None None None Rat 9.4 pIC50 = 9.4 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 538 12 1 6 5.2 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(CCC(C)C)CCC(C)C)cc1 10.1021/jm9505369
CHEMBL269141 197620 0 None None None Rat 9.4 pIC50 = 9.4 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 538 12 1 6 5.2 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(CCC(C)C)CCC(C)C)cc1 10.1021/jm9505369
10182624 199752 0 None None None Human 9.4 pIC50 = 9.4 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 453 6 2 6 4.9 CCc1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm000349x
CHEMBL283582 199752 0 None None None Human 9.4 pIC50 = 9.4 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 453 6 2 6 4.9 CCc1cc(C)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm000349x
9870830 473662 29 None None None Rat 9.4 pIC50 = 9.4 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/s0960-894x(97)10151-2
CHEMBL8981 473662 29 None None None Rat 9.4 pIC50 = 9.4 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/s0960-894x(97)10151-2
9825494 461602 0 None None None Human 9.4 pIC50 = 9.4 Binding
Binding affinity at human Endothelin A receptorBinding affinity at human Endothelin A receptor
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL61211 461602 0 None None None Human 9.4 pIC50 = 9.4 Binding
Binding affinity at human Endothelin A receptorBinding affinity at human Endothelin A receptor
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
44380648 239155 0 None None None Pig 9.4 pIC50 = 9.4 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 727 12 1 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCN(C)CC2)nc1OCCOc1ncc(Br)cn1 10.1016/s0960-894x(01)00682-5
CHEMBL354528 239155 0 None None None Pig 9.4 pIC50 = 9.4 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 727 12 1 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCN(C)CC2)nc1OCCOc1ncc(Br)cn1 10.1016/s0960-894x(01)00682-5
10210629 23076 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 592 15 1 7 5.0 CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
CHEMBL109644 23076 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 592 15 1 7 5.0 CCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
10167052 219204 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 578 13 1 7 4.5 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCC(C)C 10.1021/jm970101g
CHEMBL322297 219204 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 578 13 1 7 4.5 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCC(C)C 10.1021/jm970101g
44265870 474456 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 524 12 1 6 5.1 CCCCN(CCCC)C(=O)C(C)N1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9488 474456 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 524 12 1 6 5.1 CCCCN(CCCC)C(=O)C(C)N1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 10.1021/jm9505369
10391487 23965 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 506 12 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3occc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm010237l
CHEMBL112832 23965 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 506 12 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3occc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm010237l
10983045 467972 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 440 9 1 6 5.3 CCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL62762 467972 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 440 9 1 6 5.3 CCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
11050177 24551 0 None None None Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 585 10 1 9 6.1 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3ccco3)cn2)cc1 10.1021/jm0102304
CHEMBL116108 24551 0 None None None Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 585 10 1 9 6.1 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(-c3ccco3)cn2)cc1 10.1021/jm0102304
177372766 394391 0 None None None Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane at 25 degC incubated for 3 hrs by radioligand competition binding assayDisplacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane at 25 degC incubated for 3 hrs by radioligand competition binding assay
ChEMBL 532 15 1 6 5.9 CCCCN(CCCC)C(=O)CN1[C@H](c2cc(OC)c3c(c2)OCO3)C[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1016/s0014-2999(98)00891-7
CHEMBL5687007 394391 0 None None None Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane at 25 degC incubated for 3 hrs by radioligand competition binding assayDisplacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane at 25 degC incubated for 3 hrs by radioligand competition binding assay
ChEMBL 532 15 1 6 5.9 CCCCN(CCCC)C(=O)CN1[C@H](c2cc(OC)c3c(c2)OCO3)C[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1016/s0014-2999(98)00891-7
9915028 23715 19 None None None Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-endothelin-1 binding to EDNRAInhibition of [125I]-endothelin-1 binding to EDNRA
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.6019/CHEMBL4507258
CHEMBL111612 23715 19 None None None Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]-endothelin-1 binding to EDNRAInhibition of [125I]-endothelin-1 binding to EDNRA
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.6019/CHEMBL4507258
9915028 23715 19 None None None Human 9.3 pIC50 = 9.3 Binding
Inhibitory activity against human endothelin A receptorInhibitory activity against human endothelin A receptor
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm010237l
CHEMBL111612 23715 19 None None None Human 9.3 pIC50 = 9.3 Binding
Inhibitory activity against human endothelin A receptorInhibitory activity against human endothelin A receptor
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm010237l
10391487 23965 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 506 12 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3occc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm031041j
CHEMBL112832 23965 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 506 12 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3occc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm031041j
10840068 123125 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 536 11 1 9 4.4 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm031041j
CHEMBL174573 123125 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 536 11 1 9 4.4 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm031041j
44387124 258782 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 524 13 1 6 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](CC(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm031041j
CHEMBL368558 258782 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 524 13 1 6 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](CC(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm031041j
10530409 20039 0 None None None Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 536 9 1 10 3.9 COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
CHEMBL10781 20039 0 None None None Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 536 9 1 10 3.9 COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
10815823 24100 0 None None None Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 520 8 1 9 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1C 10.1021/jm9606507
CHEMBL11369 24100 0 None None None Human 9.3 pIC50 = 9.3 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 520 8 1 9 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1C 10.1021/jm9606507
15411009 216830 0 None None None Human 9.3 pIC50 = 9.3 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 691 14 1 12 5.6 CCOC(=O)C(CC(C)C)NC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 10.1016/S0960-894X(97)00002-4
CHEMBL316523 216830 0 None None None Human 9.3 pIC50 = 9.3 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 691 14 1 12 5.6 CCOC(=O)C(CC(C)C)NC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 10.1016/S0960-894X(97)00002-4
10391487 23965 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 506 12 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3occc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL112832 23965 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 506 12 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3occc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
16004692 4984 61 None None None Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1016/j.bmcl.2016.06.014
4809 4984 61 None None None Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1016/j.bmcl.2016.06.014
7352 4984 61 None None None Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1016/j.bmcl.2016.06.014
CHEMBL2103873 4984 61 None None None Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1016/j.bmcl.2016.06.014
DB08932 4984 61 None None None Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1016/j.bmcl.2016.06.014
157574 159953 9 None None None Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 517 4 1 5 5.0 CCc1cc(C2=C(C(=O)O)N(c3ccccc3C(F)(F)F)S(=O)(=O)c3ccccc32)cc2c1OCO2 10.1016/j.bmcl.2016.06.014
CHEMBL2110610 159953 9 None None None Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 517 4 1 5 5.0 CCc1cc(C2=C(C(=O)O)N(c3ccccc3C(F)(F)F)S(=O)(=O)c3ccccc32)cc2c1OCO2 10.1016/j.bmcl.2016.06.014
21041283 347259 0 None None None Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 552 13 2 9 3.2 CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(OC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4521348 347259 0 None None None Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 552 13 2 9 3.2 CCCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(OC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
155544917 347511 0 None None None Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 540 13 2 10 3.4 CCCNS(=O)(=O)Nc1ncnc(OCCOc2cc(OC)ccc2Cl)c1-c1ncc(SC)cn1 10.1016/j.bmcl.2016.06.014
CHEMBL4528516 347511 0 None None None Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 540 13 2 10 3.4 CCCNS(=O)(=O)Nc1ncnc(OCCOc2cc(OC)ccc2Cl)c1-c1ncc(SC)cn1 10.1016/j.bmcl.2016.06.014
16004692 4984 61 None None None Human 9.3 pIC50 = 9.3 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1021/jm3009103
4809 4984 61 None None None Human 9.3 pIC50 = 9.3 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1021/jm3009103
7352 4984 61 None None None Human 9.3 pIC50 = 9.3 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1021/jm3009103
CHEMBL2103873 4984 61 None None None Human 9.3 pIC50 = 9.3 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1021/jm3009103
DB08932 4984 61 None None None Human 9.3 pIC50 = 9.3 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1021/jm3009103
44279554 199537 0 None None None Human 9.3 pIC50 = 9.3 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 512 11 2 7 3.8 COCCNC(=O)c1cccc(S(=O)(=O)Nc2ncc(C)nc2OC)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
CHEMBL282187 199537 0 None None None Human 9.3 pIC50 = 9.3 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 512 11 2 7 3.8 COCCNC(=O)c1cccc(S(=O)(=O)Nc2ncc(C)nc2OC)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
11754394 218220 0 None None None Human 9.3 pIC50 = 9.3 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 468 8 2 6 3.8 CNC(=O)c1cccc(S(=O)(=O)Nc2ncc(C)nc2OC)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
CHEMBL32066 218220 0 None None None Human 9.3 pIC50 = 9.3 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 468 8 2 6 3.8 CNC(=O)c1cccc(S(=O)(=O)Nc2ncc(C)nc2OC)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
9933950 461665 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL62395 461665 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
10553384 219232 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 498 13 1 7 3.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1cccn1 10.1021/jm980217s
CHEMBL322537 219232 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 498 13 1 7 3.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1cccn1 10.1021/jm980217s
44333721 332558 0 None None None Human 9.3 pIC50 = 9.3 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 447 7 1 6 4.3 CCOCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
CHEMBL430506 332558 0 None None None Human 9.3 pIC50 = 9.3 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 447 7 1 6 4.3 CCOCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
14516 397 1 None None None Rat 9.3 pIC50 = 9.3 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1021/jm970101g
9916235 397 1 None None None Rat 9.3 pIC50 = 9.3 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1021/jm970101g
CHEMBL111277 397 1 None None None Rat 9.3 pIC50 = 9.3 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1021/jm970101g
10994374 468433 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 7 1 6 5.4 COc1ccc(CC2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL65619 468433 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 7 1 6 5.4 COc1ccc(CC2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
10651146 218451 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 596 12 1 8 4.4 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccc(OC)cc1 10.1021/jm970101g
CHEMBL321035 218451 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 596 12 1 8 4.4 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccc(OC)cc1 10.1021/jm970101g
10982740 468402 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 422 5 1 5 5.4 CC(C)Oc1ccc2c(c1)C(C1CCCC1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL65353 468402 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 422 5 1 5 5.4 CC(C)Oc1ccc2c(c1)C(C1CCCC1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
10187997 219519 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 564 13 1 7 4.2 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
CHEMBL323464 219519 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 564 13 1 7 4.2 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1 10.1021/jm970101g
10651488 328358 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 618 13 1 7 4.8 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F 10.1021/jm970101g
CHEMBL419367 328358 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 618 13 1 7 4.8 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)CCCC(F)(F)F 10.1021/jm970101g
9915510 176106 0 None None None Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 549 8 2 8 3.4 CCOc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1016/s0960-894x(01)00660-6
CHEMBL22513 176106 0 None None None Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 549 8 2 8 3.4 CCOc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1016/s0960-894x(01)00660-6
9915510 176106 0 None None None Human 9.3 pIC50 = 9.3 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 549 8 2 8 3.4 CCOc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1007/s00044-004-0021-y
CHEMBL22513 176106 0 None None None Human 9.3 pIC50 = 9.3 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 549 8 2 8 3.4 CCOc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1007/s00044-004-0021-y
44334097 219611 0 None None None Human 9.3 pIC50 = 9.3 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 447 7 2 6 3.7 COc1ccc([C@@H]2c3nc(CCCO)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
CHEMBL323561 219611 0 None None None Human 9.3 pIC50 = 9.3 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 447 7 2 6 3.7 COc1ccc([C@@H]2c3nc(CCCO)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
10719598 473922 0 None None None Human 9.3 pIC50 = 9.3 Binding
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 482 10 1 6 3.9 CCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9139 473922 0 None None None Human 9.3 pIC50 = 9.3 Binding
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 482 10 1 6 3.9 CCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
9915028 23715 19 None None None Rat 9.3 pIC50 = 9.3 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
CHEMBL111612 23715 19 None None None Rat 9.3 pIC50 = 9.3 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
177372766 394391 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Displacement of [125I]endhothelin-1 from ETA receptor in rat MMQ cells Membrane at 25 degC incubated for 3 hrs by radioligand competition binding assayDisplacement of [125I]endhothelin-1 from ETA receptor in rat MMQ cells Membrane at 25 degC incubated for 3 hrs by radioligand competition binding assay
ChEMBL 532 15 1 6 5.9 CCCCN(CCCC)C(=O)CN1[C@H](c2cc(OC)c3c(c2)OCO3)C[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1016/s0014-2999(98)00891-7
CHEMBL5687007 394391 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Displacement of [125I]endhothelin-1 from ETA receptor in rat MMQ cells Membrane at 25 degC incubated for 3 hrs by radioligand competition binding assayDisplacement of [125I]endhothelin-1 from ETA receptor in rat MMQ cells Membrane at 25 degC incubated for 3 hrs by radioligand competition binding assay
ChEMBL 532 15 1 6 5.9 CCCCN(CCCC)C(=O)CN1[C@H](c2cc(OC)c3c(c2)OCO3)C[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1016/s0014-2999(98)00891-7
10886132 24112 0 None None None Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 549 10 1 9 4.8 COc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)cc2)nc1 10.1021/jm0102304
CHEMBL113757 24112 0 None None None Rat 9.3 pIC50 = 9.3 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 549 10 1 9 4.8 COc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C)cc2)nc1 10.1021/jm0102304
10744973 474180 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 538 14 1 6 5.5 CCCCCN(CCCCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9313 474180 0 None None None Rat 9.3 pIC50 = 9.3 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 538 14 1 6 5.5 CCCCCN(CCCCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10209779 328407 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 560 14 1 7 4.5 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm970101g
CHEMBL419749 328407 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 560 14 1 7 4.5 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm970101g
11015826 468539 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 450 6 1 5 6.1 CC(C)Oc1ccc2c(c1)C(CC1CCCCC1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL66426 468539 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 450 6 1 5 6.1 CC(C)Oc1ccc2c(c1)C(CC1CCCCC1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
9915028 23715 19 None None None Human 9.2 pIC50 = 9.2 Binding
Affinity On-target Cellular interaction (Endothelin-1-evoked phosphatidylinositol hydrolysis in MMQ cells) EUB0000348aPTSA EDNRAAffinity On-target Cellular interaction (Endothelin-1-evoked phosphatidylinositol hydrolysis in MMQ cells) EUB0000348aPTSA EDNRA
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.6019/CHEMBL5210121
CHEMBL111612 23715 19 None None None Human 9.2 pIC50 = 9.2 Binding
Affinity On-target Cellular interaction (Endothelin-1-evoked phosphatidylinositol hydrolysis in MMQ cells) EUB0000348aPTSA EDNRAAffinity On-target Cellular interaction (Endothelin-1-evoked phosphatidylinositol hydrolysis in MMQ cells) EUB0000348aPTSA EDNRA
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.6019/CHEMBL5210121
10346184 23501 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 508 12 1 5 4.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm010237l
CHEMBL110366 23501 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 508 12 1 5 4.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm010237l
15411005 19100 0 None None None Human 9.2 pIC50 = 9.2 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 677 13 1 12 5.2 CCOC(=O)C(NC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1)C(C)C 10.1016/S0960-894X(97)00002-4
CHEMBL103846 19100 0 None None None Human 9.2 pIC50 = 9.2 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 677 13 1 12 5.2 CCOC(=O)C(NC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1)C(C)C 10.1016/S0960-894X(97)00002-4
10346184 23501 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 508 12 1 5 4.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL110366 23501 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 508 12 1 5 4.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL2373291 485962 0 None None None Pig 9.2 pIC50 = 9.2 Binding
Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorTested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptor
ChEMBL 2516 46 32 36 -3.9 CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00077a013
10579303 23735 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 590 16 1 8 4.5 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCOC)cc1 10.1021/jm970101g
CHEMBL111712 23735 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 590 16 1 8 4.5 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCOC)cc1 10.1021/jm970101g
11015645 468225 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 438 9 1 5 6.1 CCCCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL64282 468225 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 438 9 1 5 6.1 CCCCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
10938122 328016 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 396 5 1 5 4.8 CC(C)Oc1ccc2c(c1)C(C(C)C)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL417555 328016 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 396 5 1 5 4.8 CC(C)Oc1ccc2c(c1)C(C(C)C)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
10503921 201599 0 None None None Human 9.2 pIC50 = 9.2 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 454 6 1 8 4.0 Cc1cc2c(cc1CC(=O)c1sccc1S(=O)(=O)Nc1noc(C)c1Cl)OCO2 10.1021/jm9700068
CHEMBL297783 201599 0 None None None Human 9.2 pIC50 = 9.2 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 454 6 1 8 4.0 Cc1cc2c(cc1CC(=O)c1sccc1S(=O)(=O)Nc1noc(C)c1Cl)OCO2 10.1021/jm9700068
44279141 216676 0 None None None Human 9.2 pIC50 = 9.2 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 498 10 3 7 3.2 COc1nc(C)cnc1NS(=O)(=O)c1cccc(C(=O)NCCO)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
CHEMBL31544 216676 0 None None None Human 9.2 pIC50 = 9.2 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 498 10 3 7 3.2 COc1nc(C)cnc1NS(=O)(=O)c1cccc(C(=O)NCCO)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
10552883 219548 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 484 13 1 5 4.8 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC=C1CC1 10.1021/jm980217s
CHEMBL323485 219548 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 484 13 1 5 4.8 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC=C1CC1 10.1021/jm980217s
10974047 23821 0 None None None Pig 9.2 pIC50 = 9.2 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 601 11 1 10 4.3 COc1ccc(S(=O)(=O)Nc2ncnc(OCCOc3ncc(Br)cn3)c2-c2ccc(C)cc2)cc1OC 10.1021/jm0102304
CHEMBL112162 23821 0 None None None Pig 9.2 pIC50 = 9.2 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 601 11 1 10 4.3 COc1ccc(S(=O)(=O)Nc2ncnc(OCCOc3ncc(Br)cn3)c2-c2ccc(C)cc2)cc1OC 10.1021/jm0102304
10745942 23616 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 588 13 1 8 4.3 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc2c(c1)OCCO2 10.1021/jm970101g
CHEMBL111010 23616 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 588 13 1 8 4.3 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc2c(c1)OCCO2 10.1021/jm970101g
11080933 468430 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 454 10 1 6 5.7 CCCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL65599 468430 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 454 10 1 6 5.7 CCCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
10166223 467203 0 None None None Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 552 7 2 7 5.5 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)N(C)CC(C)(C)C)c1 10.1021/jm030528p
CHEMBL61711 467203 0 None None None Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 552 7 2 7 5.5 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)N(C)CC(C)(C)C)c1 10.1021/jm030528p
10076527 38521 0 None None None Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 485 7 2 6 4.3 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3ccccc31)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1204990 38521 0 None None None Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 485 7 2 6 4.3 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3ccccc31)OCO2 10.1016/j.bmcl.2010.08.074
10720982 255760 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 530 9 2 6 4.8 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)C)cc1 10.1021/jm031041j
CHEMBL366441 255760 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 530 9 2 6 4.8 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)C)cc1 10.1021/jm031041j
71462320 163431 0 None None None Human 9.2 pIC50 = 9.2 Binding
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 570 11 2 8 3.9 Cc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL2165332 163431 0 None None None Human 9.2 pIC50 = 9.2 Binding
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 570 11 2 8 3.9 Cc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1016/j.bmcl.2016.06.014
10720982 255760 0 None None None Human 9.2 pIC50 = 9.2 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 530 9 2 6 4.8 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)C)cc1 10.1021/jm990171i
CHEMBL366441 255760 0 None None None Human 9.2 pIC50 = 9.2 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 530 9 2 6 4.8 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)C)cc1 10.1021/jm990171i
10649266 23936 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 506 12 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3ccoc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL112685 23936 0 None None None Rat 9.2 pIC50 = 9.2 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 506 12 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3ccoc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
11505449 336021 0 None None None Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 616 12 3 9 2.6 O=C(O)CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4463633 336021 0 None None None Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 616 12 3 9 2.6 O=C(O)CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
58688005 348989 0 None None None Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 540 11 2 9 3.1 CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4565926 348989 0 None None None Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 540 11 2 9 3.1 CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
71462320 163431 0 None None None Human 9.2 pIC50 = 9.2 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 570 11 2 8 3.9 Cc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm3009103
CHEMBL2165332 163431 0 None None None Human 9.2 pIC50 = 9.2 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 570 11 2 8 3.9 Cc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm3009103
10746431 202391 0 None None None Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 619 12 1 11 3.9 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCN3CCOCC3)c2)cc1 10.1021/jm980504w
CHEMBL303484 202391 0 None None None Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 619 12 1 11 3.9 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCN3CCOCC3)c2)cc1 10.1021/jm980504w
9809919 469315 0 None None None Human 9.2 pIC50 = 9.2 Binding
Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cellsReceptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cells
ChEMBL 665 13 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL72037 469315 0 None None None Human 9.2 pIC50 = 9.2 Binding
Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cellsReceptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cells
ChEMBL 665 13 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL2373292 485963 0 None None None Pig 9.2 pIC50 = 9.2 Binding
Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorTested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptor
ChEMBL 2490 45 32 36 -4.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00077a013
9870959 23227 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 509 13 1 6 4.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 10.1021/jm980217s
CHEMBL109778 23227 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 509 13 1 6 4.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccccn1 10.1021/jm980217s
10916597 468343 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 410 7 1 5 5.4 CCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL64832 468343 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 410 7 1 5 5.4 CCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
44284184 277294 0 None None None Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 490 8 2 7 5.0 CCOc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
CHEMBL38000 277294 0 None None None Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 490 8 2 7 5.0 CCOc1cc(OC)ccc1[C@@H]1c2nc(NC(C)C)ccc2[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1016/j.bmcl.2004.01.008
CHEMBL427748 488487 0 None None None Pig 9.1 pIC50 = 9.1 Binding
Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorTested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptor
ChEMBL 2490 47 32 36 -4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00077a013
11827489 235853 0 None None None Human 9.1 pIC50 = 9.1 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 524 12 1 4 5.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)c(F)c1 10.1021/jm010237l
CHEMBL338754 235853 0 None None None Human 9.1 pIC50 = 9.1 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 524 12 1 4 5.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)c(F)c1 10.1021/jm010237l
10984671 23777 0 None None None Pig 9.1 pIC50 = 9.1 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 571 10 1 9 4.3 COc1ccc(S(=O)(=O)Nc2ncnc(OCCOc3ncc(Br)cn3)c2-c2ccc(C)cc2)cc1 10.1021/jm0102304
CHEMBL111934 23777 0 None None None Pig 9.1 pIC50 = 9.1 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 571 10 1 9 4.3 COc1ccc(S(=O)(=O)Nc2ncnc(OCCOc3ncc(Br)cn3)c2-c2ccc(C)cc2)cc1 10.1021/jm0102304
10648006 317204 0 None None None Human 9.1 pIC50 = 9.1 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 468 6 1 6 4.7 Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1021/jm9700068
CHEMBL413093 317204 0 None None None Human 9.1 pIC50 = 9.1 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 468 6 1 6 4.7 Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1021/jm9700068
10648135 23647 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 472 13 1 5 4.7 C/C=C/CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm031041j
CHEMBL111218 23647 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 472 13 1 5 4.7 C/C=C/CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm031041j
10209320 23590 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 546 12 1 7 4.0 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CC(C)C 10.1021/jm970101g
CHEMBL110899 23590 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 546 12 1 7 4.0 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CC(C)C 10.1021/jm970101g
11038320 42732 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 492 11 1 4 5.2 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)cc1 10.1021/jm010237l
CHEMBL128240 42732 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 492 11 1 4 5.2 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)cc1 10.1021/jm010237l
10552413 213024 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 472 13 1 5 4.7 C/C=C\CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
CHEMBL325935 213024 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 472 13 1 5 4.7 C/C=C\CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
44340049 219867 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 500 13 1 5 5.3 C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
CHEMBL323951 219867 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 500 13 1 5 5.3 C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
44266851 38491 0 None None None Human 9.1 pIC50 = 9.1 Binding
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 550 11 1 9 4.7 COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1C 10.1021/jm9606507
CHEMBL1204671 38491 0 None None None Human 9.1 pIC50 = 9.1 Binding
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 550 11 1 9 4.7 COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1C 10.1021/jm9606507
44279316 216975 0 None None None Human 9.1 pIC50 = 9.1 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 518 8 2 6 4.0 COc1nc(Br)cnc1NS(=O)(=O)c1cccc(C(N)=O)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
CHEMBL31763 216975 0 None None None Human 9.1 pIC50 = 9.1 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 518 8 2 6 4.0 COc1nc(Br)cnc1NS(=O)(=O)c1cccc(C(N)=O)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
137649592 313310 0 None None None Human 9.1 pIC50 = 9.1 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 567 10 2 9 4.6 CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4078537 313310 0 None None None Human 9.1 pIC50 = 9.1 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 567 10 2 9 4.6 CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
15411003 218310 0 None None None Human 9.1 pIC50 = 9.1 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 589 11 1 10 4.8 C=CCNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 10.1016/S0960-894X(97)00002-4
CHEMBL320839 218310 0 None None None Human 9.1 pIC50 = 9.1 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 589 11 1 10 4.8 C=CCNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 10.1016/S0960-894X(97)00002-4
10673644 24085 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 524 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL113611 24085 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 524 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
177236 2734 40 None None None Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/s0960-894x(01)00660-6
3508 2734 40 None None None Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/s0960-894x(01)00660-6
9931375 2734 40 None None None Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/s0960-894x(01)00660-6
9953358 2734 40 None None None Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/s0960-894x(01)00660-6
CHEMBL23261 2734 40 None None None Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/s0960-894x(01)00660-6
CHEMBL25344 2734 40 None None None Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/s0960-894x(01)00660-6
CHEMBL5687038 2734 40 None None None Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/s0960-894x(01)00660-6
DB04883 2734 40 None None None Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/s0960-894x(01)00660-6
71462322 163437 22 None None None Human 9.1 pIC50 = 9.1 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 572 10 2 8 3.2 CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
CHEMBL2165338 163437 22 None None None Human 9.1 pIC50 = 9.1 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 572 10 2 8 3.2 CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
44284199 200285 0 None None None Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 552 9 2 7 6.2 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OCc2ccccc2)c1 10.1016/j.bmcl.2004.01.008
CHEMBL287517 200285 0 None None None Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 552 9 2 7 6.2 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OCc2ccccc2)c1 10.1016/j.bmcl.2004.01.008
10993320 468035 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 412 6 1 6 4.6 CC(C)OC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL63067 468035 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 412 6 1 6 4.6 CC(C)OC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
10097589 473260 0 None None None Rat 9.1 pIC50 = 9.1 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 502 7 2 7 5.2 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCC(C(=O)O)CC1 10.1016/s0960-894x(00)00513-8
CHEMBL86965 473260 0 None None None Rat 9.1 pIC50 = 9.1 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 502 7 2 7 5.2 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCC(C(=O)O)CC1 10.1016/s0960-894x(00)00513-8
10792319 474139 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 530 10 1 6 5.1 CCCCN(C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm9505369
CHEMBL9283 474139 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 530 10 1 6 5.1 CCCCN(C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm9505369
10648937 474209 0 None None None Human 9.1 pIC50 = 9.1 Binding
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 496 11 1 6 4.3 CCCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9334 474209 0 None None None Human 9.1 pIC50 = 9.1 Binding
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 496 11 1 6 4.3 CCCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10673644 24085 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 524 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm010237l
CHEMBL113611 24085 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 524 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm010237l
10814655 474485 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 482 10 1 6 3.9 CCCCN(CC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9502 474485 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 482 10 1 6 3.9 CCCCN(CC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
44339714 220816 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 500 14 1 5 5.4 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC/C=C(/C)CC 10.1021/jm980217s
CHEMBL326685 220816 0 None None None Rat 9.1 pIC50 = 9.1 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 500 14 1 5 5.4 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC/C=C(/C)CC 10.1021/jm980217s
10984617 24310 0 None None None Pig 9.1 pIC50 = 9.1 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 565 11 1 10 4.9 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(C)cn2)c1 10.1021/jm0102304
CHEMBL114933 24310 0 None None None Pig 9.1 pIC50 = 9.1 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 565 11 1 10 4.9 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncc(C)cn2)c1 10.1021/jm0102304
44284183 276884 0 None None None Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 518 9 2 7 5.7 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OCC(C)C)c1 10.1016/j.bmcl.2004.01.008
CHEMBL37973 276884 0 None None None Human 9.1 pIC50 = 9.1 Binding
Inhibitory activity against [125I]ET1 binding to human endothelin A receptorInhibitory activity against [125I]ET1 binding to human endothelin A receptor
ChEMBL 518 9 2 7 5.7 COc1ccc([C@@H]2c3nc(NC(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)c(OCC(C)C)c1 10.1016/j.bmcl.2004.01.008
11027946 42772 0 None None None Human 9.1 pIC50 = 9.1 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 540 12 1 5 5.4 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)c(F)c1 10.1021/jm010237l
CHEMBL128479 42772 0 None None None Human 9.1 pIC50 = 9.1 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 540 12 1 5 5.4 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)c(F)c1 10.1021/jm010237l
11006213 333867 0 None None None Pig 9.1 pIC50 = 9.1 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 557 10 1 10 5.3 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2cccs2)nc1 10.1021/jm0102304
CHEMBL441277 333867 0 None None None Pig 9.1 pIC50 = 9.1 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 557 10 1 10 5.3 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2cccs2)nc1 10.1021/jm0102304
10602743 21479 0 None None None Human 9.1 pIC50 = 9.1 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 550 9 1 10 4.2 COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1C 10.1021/jm9606507
CHEMBL10854 21479 0 None None None Human 9.1 pIC50 = 9.1 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 550 9 1 10 4.2 COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1C 10.1021/jm9606507
10983992 43313 0 None None None Rat 9.0 pIC50 = 9.0 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 506 12 1 4 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)cc1 10.1021/jm010237l
CHEMBL129740 43313 0 None None None Rat 9.0 pIC50 = 9.0 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 506 12 1 4 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)cc1 10.1021/jm010237l
44333598 218768 0 None None None Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 447 7 1 6 4.6 CCCOc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
CHEMBL321520 218768 0 None None None Human 9.0 pIC50 = 9.0 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 447 7 1 6 4.6 CCCOc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
11037806 467903 0 None None None Rat 9.0 pIC50 = 9.0 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 456 10 2 7 4.3 CC(C)Oc1ccc2c(c1)C(OCCCCCO)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL62376 467903 0 None None None Rat 9.0 pIC50 = 9.0 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 456 10 2 7 4.3 CC(C)Oc1ccc2c(c1)C(OCCCCCO)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
10788494 335173 0 None None None Human 9.0 pIC50 = 9.0 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 424 6 1 6 4.5 Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1021/jm9700068
CHEMBL445101 335173 0 None None None Human 9.0 pIC50 = 9.0 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 424 6 1 6 4.5 Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1021/jm9700068
10768294 38494 0 None None None Human 9.0 pIC50 = 9.0 Binding
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 520 10 1 8 4.7 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1C 10.1021/jm9606507
CHEMBL1204674 38494 0 None None None Human 9.0 pIC50 = 9.0 Binding
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 520 10 1 8 4.7 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1C 10.1021/jm9606507
10625694 25723 0 None None None Human 9.0 pIC50 = 9 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 516 9 2 6 4.5 CCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm990171i
CHEMBL1180344 25723 0 None None None Human 9.0 pIC50 = 9 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 516 9 2 6 4.5 CCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm990171i
9868379 200927 0 None None None Rat 9.0 pIC50 = 9 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 450 5 1 6 5.6 Cc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)s1 10.1021/jm010382z
CHEMBL293012 200927 0 None None None Rat 9.0 pIC50 = 9 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 450 5 1 6 5.6 Cc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)s1 10.1021/jm010382z
44332842 219281 0 None None None Human 9.0 pIC50 = 9 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 703 11 1 10 7.5 COc1ccc(C2(OC(=O)N[C@@H](C)c3cccc4ccccc34)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/S0960-894X(97)00002-4
CHEMBL322920 219281 0 None None None Human 9.0 pIC50 = 9 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 703 11 1 10 7.5 COc1ccc(C2(OC(=O)N[C@@H](C)c3cccc4ccccc34)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/S0960-894X(97)00002-4
44314904 203196 0 None None None Pig 9.0 pIC50 = 9 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 585 12 5 5 3.6 CSCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
CHEMBL307936 203196 0 None None None Pig 9.0 pIC50 = 9 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 585 12 5 5 3.6 CSCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
10649321 220465 0 None None None Rat 9.0 pIC50 = 9 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 508 12 1 5 4.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL326191 220465 0 None None None Rat 9.0 pIC50 = 9 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 508 12 1 5 4.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
197712 807 76 None None None Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
3951 807 76 None None None Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
4337 807 76 None None None Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
6918493 807 76 None None None Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
CHEMBL1111 807 76 None None None Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
CHEMBL302753 807 76 None None None Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
DB06403 807 76 None None None Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
9868379 200927 0 None None None Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 450 5 1 6 5.6 Cc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)s1 10.1016/j.bmcl.2016.06.014
CHEMBL293012 200927 0 None None None Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 450 5 1 6 5.6 Cc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)s1 10.1016/j.bmcl.2016.06.014
155519384 334972 0 None None None Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 674 12 1 13 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)c1ccccn1 10.1016/j.bmcl.2016.06.014
CHEMBL4448273 334972 0 None None None Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 674 12 1 13 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)c1ccccn1 10.1016/j.bmcl.2016.06.014
155551580 348061 0 None None None Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 526 12 2 10 3.0 CCNS(=O)(=O)Nc1ncnc(OCCOc2cc(OC)ccc2Cl)c1-c1ncc(SC)cn1 10.1016/j.bmcl.2016.06.014
CHEMBL4542394 348061 0 None None None Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 526 12 2 10 3.0 CCNS(=O)(=O)Nc1ncnc(OCCOc2cc(OC)ccc2Cl)c1-c1ncc(SC)cn1 10.1016/j.bmcl.2016.06.014
10146305 348328 0 None None None Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 656 14 2 13 4.2 COc1ccccc1Oc1c(NS(=O)(=O)CCc2cccs2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/j.bmcl.2016.06.014
CHEMBL4549357 348328 0 None None None Human 9.0 pIC50 = 9 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 656 14 2 13 4.2 COc1ccccc1Oc1c(NS(=O)(=O)CCc2cccs2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/j.bmcl.2016.06.014
44439102 181123 0 None None None Human 9.0 pIC50 = 9 Binding
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 508 8 1 7 5.2 CN(Cc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1ccno1)C(=O)CC(C)(C)C 10.1016/j.bmcl.2006.10.009
CHEMBL238539 181123 0 None None None Human 9.0 pIC50 = 9 Binding
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 508 8 1 7 5.2 CN(Cc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1ccno1)C(=O)CC(C)(C)C 10.1016/j.bmcl.2006.10.009
71460621 163428 0 None None None Human 9.0 pIC50 = 9 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 602 13 2 10 3.7 COc1cccc(Oc2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)c1 10.1021/jm3009103
CHEMBL2165329 163428 0 None None None Human 9.0 pIC50 = 9 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 602 13 2 10 3.7 COc1cccc(Oc2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)c1 10.1021/jm3009103
44295173 38539 0 None None None Rat 9.0 pIC50 = 9 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 554 10 1 9 5.3 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1Cl 10.1016/s0960-894x(98)00301-1
CHEMBL1205090 38539 0 None None None Rat 9.0 pIC50 = 9 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 554 10 1 9 5.3 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1Cl 10.1016/s0960-894x(98)00301-1
44279398 200072 0 None None None Human 9.0 pIC50 = 9 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 454 8 2 6 3.6 COc1nc(C)cnc1NS(=O)(=O)c1cccc(C(N)=O)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
CHEMBL285976 200072 0 None None None Human 9.0 pIC50 = 9 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 454 8 2 6 3.6 COc1nc(C)cnc1NS(=O)(=O)c1cccc(C(N)=O)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
44279294 200079 0 None None None Human 9.0 pIC50 = 9 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 546 8 1 6 4.6 COc1nc(Br)cnc1NS(=O)(=O)c1cccc(C(=O)N(C)C)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
CHEMBL286014 200079 0 None None None Human 9.0 pIC50 = 9 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 546 8 1 6 4.6 COc1nc(Br)cnc1NS(=O)(=O)c1cccc(C(=O)N(C)C)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
10897248 23813 0 None None None Pig 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 591 9 1 8 5.4 Cc1ccc(-c2c(NS(=O)(=O)c3ccc4ccccc4c3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
CHEMBL112134 23813 0 None None None Pig 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 591 9 1 8 5.4 Cc1ccc(-c2c(NS(=O)(=O)c3ccc4ccccc4c3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
11136124 24658 0 None None None Pig 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 667 9 1 8 4.9 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(I)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
CHEMBL116220 24658 0 None None None Pig 9.0 pIC50 = 9 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 667 9 1 8 4.9 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(I)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
10211781 257657 0 None None None Human 9.0 pIC50 = 9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
CHEMBL367453 257657 0 None None None Human 9.0 pIC50 = 9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
10146640 474440 0 None None None Human 9.0 pIC50 = 9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 689 12 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
CHEMBL94786 474440 0 None None None Human 9.0 pIC50 = 9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 689 12 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
10555191 468776 0 None None None Human 9.0 pIC50 = 9 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 577 12 1 10 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCN(C)C)c2)cc1 10.1021/jm980504w
CHEMBL68269 468776 0 None None None Human 9.0 pIC50 = 9 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 577 12 1 10 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCN(C)C)c2)cc1 10.1021/jm980504w
CHEMBL1790519 484803 0 None None None Human 9.0 pIC50 = 9 Binding
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 964 23 8 8 4.6 CC[C@H](C)[C@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N(C)[C@@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1021/jm970161m
44311346 203212 0 None None None Human 9.0 pIC50 = 9 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 681 13 2 13 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCSCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL308088 203212 0 None None None Human 9.0 pIC50 = 9 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 681 13 2 13 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCSCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44340049 219867 0 None None None Human 9.0 pIC50 = 9 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 500 13 1 5 5.3 C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
CHEMBL323951 219867 0 None None None Human 9.0 pIC50 = 9 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 500 13 1 5 5.3 C/C=C\C(C)(C)C[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
44339662 24155 0 None None None Rat 9.0 pIC50 = 9.0 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 527 13 1 7 4.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1nc(C)c(C)o1 10.1021/jm980217s
CHEMBL114074 24155 0 None None None Rat 9.0 pIC50 = 9.0 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 527 13 1 7 4.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1nc(C)c(C)o1 10.1021/jm980217s
44351961 42695 0 None None None Rat 9.0 pIC50 = 9.0 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 522 13 1 5 5.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CCC)cc1 10.1021/jm010237l
CHEMBL128061 42695 0 None None None Rat 9.0 pIC50 = 9.0 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 522 13 1 5 5.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CCC)cc1 10.1021/jm010237l
10553384 219232 0 None None None Human 9.0 pIC50 = 9.0 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 498 13 1 7 3.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1cccn1 10.1021/jm980217s
CHEMBL322537 219232 0 None None None Human 9.0 pIC50 = 9.0 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 498 13 1 7 3.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1cccn1 10.1021/jm980217s
9909467 470347 0 None None None Human 9.0 pIC50 = 9.0 Binding
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 409 4 1 5 3.8 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL80782 470347 0 None None None Human 9.0 pIC50 = 9.0 Binding
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 409 4 1 5 3.8 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1Br 10.1016/0960-894X(96)00441-6
9827093 347521 0 None None None Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 494 9 2 7 5.1 CCCc1nc(SC2CCC(CC(=O)O)CC2)c(C(=O)O)n1Cc1cc2c(cc1Cl)OCO2 10.1016/j.bmcl.2016.06.014
CHEMBL4528664 347521 0 None None None Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 494 9 2 7 5.1 CCCc1nc(SC2CCC(CC(=O)O)CC2)c(C(=O)O)n1Cc1cc2c(cc1Cl)OCO2 10.1016/j.bmcl.2016.06.014
10347080 176178 0 None None None Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 535 7 2 8 3.0 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1016/s0960-894x(01)00660-6
CHEMBL22562 176178 0 None None None Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 535 7 2 8 3.0 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1016/s0960-894x(01)00660-6
10347080 176178 0 None None None Human 9.0 pIC50 = 9.0 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 535 7 2 8 3.0 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1007/s00044-004-0021-y
CHEMBL22562 176178 0 None None None Human 9.0 pIC50 = 9.0 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 535 7 2 8 3.0 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1007/s00044-004-0021-y
71449713 163097 30 None None None Human 9.0 pIC50 = 9.0 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 585 11 1 8 4.5 CCCCS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
CHEMBL2163694 163097 30 None None None Human 9.0 pIC50 = 9.0 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 585 11 1 8 4.5 CCCCS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
71458719 163107 0 None None None Human 9.0 pIC50 = 9.0 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 647 15 1 13 4.7 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(SC)cn1 10.1021/jm3009103
CHEMBL2163704 163107 0 None None None Human 9.0 pIC50 = 9.0 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 647 15 1 13 4.7 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(SC)cn1 10.1021/jm3009103
17885918 215658 0 None None None Rat 9.0 pIC50 = 9.0 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 458 6 1 6 5.9 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccsc2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
CHEMBL313044 215658 0 None None None Rat 9.0 pIC50 = 9.0 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 458 6 1 6 5.9 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccsc2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
9846994 215674 0 None None None Rat 9.0 pIC50 = 9.0 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 458 6 1 6 5.9 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
CHEMBL313153 215674 0 None None None Rat 9.0 pIC50 = 9.0 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 458 6 1 6 5.9 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
44380976 330500 0 None None None Pig 9.0 pIC50 = 9.0 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 639 10 1 8 6.7 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)nc(C(C)C)nc2OCCOc2ncc(Br)cn2)cc1 10.1016/s0960-894x(01)00682-5
CHEMBL424358 330500 0 None None None Pig 9.0 pIC50 = 9.0 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 639 10 1 8 6.7 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)nc(C(C)C)nc2OCCOc2ncc(Br)cn2)cc1 10.1016/s0960-894x(01)00682-5
10505755 38490 0 None None None Human 9.0 pIC50 = 9.0 Binding
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 506 10 1 8 4.4 COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL1204670 38490 0 None None None Human 9.0 pIC50 = 9.0 Binding
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 506 10 1 8 4.4 COc1ccc(C(=O)/C(Cc2ccc(OC)c(OC)c2OC)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm9606507
9870830 473662 29 None None None Human 9.0 pIC50 = 9.0 Binding
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
CHEMBL8981 473662 29 None None None Human 9.0 pIC50 = 9.0 Binding
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
10142669 23748 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 518 11 1 7 3.3 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CC 10.1021/jm970101g
CHEMBL111769 23748 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 518 11 1 7 3.3 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CC 10.1021/jm970101g
137637038 311868 0 None None None Human 8.9 pIC50 = 8.9 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 581 11 2 9 5.0 CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4061110 311868 0 None None None Human 8.9 pIC50 = 8.9 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 581 11 2 9 5.0 CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
10649321 220465 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 508 12 1 5 4.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm010237l
CHEMBL326191 220465 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 508 12 1 5 4.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm010237l
10576427 19706 0 None None None Human 8.9 pIC50 = 8.9 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 473 6 2 7 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(NC(C)=O)cc2)cc1 10.1021/jm9606507
CHEMBL10697 19706 0 None None None Human 8.9 pIC50 = 8.9 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 473 6 2 7 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(NC(C)=O)cc2)cc1 10.1021/jm9606507
21041324 163093 8 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 542 11 2 8 3.5 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Cl)cc1 10.1021/jm3009103
CHEMBL2163690 163093 8 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 542 11 2 8 3.5 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Cl)cc1 10.1021/jm3009103
11093167 24354 0 None None None Pig 8.9 pIC50 = 8.9 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 593 11 1 9 6.3 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C(C)C)cc2)nc1 10.1021/jm0102304
CHEMBL115230 24354 0 None None None Pig 8.9 pIC50 = 8.9 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 593 11 1 9 6.3 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccc(C(C)C)cc2)nc1 10.1021/jm0102304
11813644 219912 0 None None None Pig 8.9 pIC50 = 8.9 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 11 1 10 4.6 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ccncn2)c1 10.1021/jm0102304
CHEMBL324246 219912 0 None None None Pig 8.9 pIC50 = 8.9 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 11 1 10 4.6 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ccncn2)c1 10.1021/jm0102304
CHEMBL414165 488327 0 None None None Human 8.9 pIC50 = 8.9 Binding
Inhibitory effect against Human ET-A receptorInhibitory effect against Human ET-A receptor
ChEMBL 650 7 6 7 1.6 CC(C)C[C@H]1NC(=O)[C@H](c2cccs2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10719598 473922 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 482 10 1 6 3.9 CCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9139 473922 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 482 10 1 6 3.9 CCCN(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
44279296 220155 0 None None None Human 8.9 pIC50 = 8.9 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 532 8 2 6 4.3 CNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
CHEMBL32572 220155 0 None None None Human 8.9 pIC50 = 8.9 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 532 8 2 6 4.3 CNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
10206812 432533 0 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 492 6 2 8 5.0 Cc1cc(-c2ncco2)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
CHEMBL59288 432533 0 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 492 6 2 8 5.0 Cc1cc(-c2ncco2)cc(C)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
11102609 333240 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 462 6 1 6 5.2 COc1ccc([C@@H]2c3cc(OC(C)C)ccc3O[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1021/jm031041j
CHEMBL435773 333240 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 462 6 1 6 5.2 COc1ccc([C@@H]2c3cc(OC(C)C)ccc3O[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1021/jm031041j
10603546 219982 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 592 15 1 7 5.0 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCC)c(F)c1 10.1021/jm970101g
CHEMBL324639 219982 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 592 15 1 7 5.0 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCC)c(F)c1 10.1021/jm970101g
11102609 333240 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 462 6 1 6 5.2 COc1ccc([C@@H]2c3cc(OC(C)C)ccc3O[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1021/jm010382z
CHEMBL435773 333240 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 462 6 1 6 5.2 COc1ccc([C@@H]2c3cc(OC(C)C)ccc3O[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1021/jm010382z
10576910 218146 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 486 13 1 5 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC=C(C)C 10.1021/jm980217s
CHEMBL320124 218146 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 486 13 1 5 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC=C(C)C 10.1021/jm980217s
10278777 332860 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 502 14 1 5 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
CHEMBL432974 332860 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 502 14 1 5 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
10767586 24072 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 496 13 1 5 5.0 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(OC)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL113529 24072 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 496 13 1 5 5.0 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(OC)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
58688008 349312 0 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 496 11 2 9 3.0 CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4573273 349312 0 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 496 11 2 9 3.0 CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
23670447 6168 2 None None None Rat 8.9 pIC50 = 8.9 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0960-894x(98)00301-1
9871594 6168 2 None None None Rat 8.9 pIC50 = 8.9 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0960-894x(98)00301-1
999 6168 2 None None None Rat 8.9 pIC50 = 8.9 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0960-894x(98)00301-1
CHEMBL1204799 6168 2 None None None Rat 8.9 pIC50 = 8.9 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0960-894x(98)00301-1
CHEMBL25438 6168 2 None None None Rat 8.9 pIC50 = 8.9 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0960-894x(98)00301-1
44320480 215643 0 None None None Rat 8.9 pIC50 = 8.9 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 442 6 1 6 5.4 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccco2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
CHEMBL312979 215643 0 None None None Rat 8.9 pIC50 = 8.9 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 442 6 1 6 5.4 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccco2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
17885920 473408 0 None None None Rat 8.9 pIC50 = 8.9 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 502 7 2 7 5.2 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCCC(C(=O)O)C1 10.1016/s0960-894x(00)00513-8
CHEMBL88011 473408 0 None None None Rat 8.9 pIC50 = 8.9 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 502 7 2 7 5.2 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccs2)nn1CC1CCCC(C(=O)O)C1 10.1016/s0960-894x(00)00513-8
44291775 201300 0 None None None Human 8.9 pIC50 = 8.9 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 506 6 1 10 4.1 CC#N.Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2cc3c(cc2C#N)OCO3)c1Cl 10.1021/jm9700068
CHEMBL295557 201300 0 None None None Human 8.9 pIC50 = 8.9 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 506 6 1 10 4.1 CC#N.Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2cc3c(cc2C#N)OCO3)c1Cl 10.1021/jm9700068
10280278 200986 0 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 535 7 2 7 6.1 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)C2CCCCC2)c1 10.1021/jm030528p
CHEMBL293421 200986 0 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 535 7 2 7 6.1 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)C2CCCCC2)c1 10.1021/jm030528p
11071347 236640 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 516 11 1 5 5.0 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(F)c(F)c1 10.1021/jm010237l
CHEMBL340190 236640 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 516 11 1 5 5.0 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(F)c(F)c1 10.1021/jm010237l
10745564 20555 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 566 11 1 7 4.4 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccccc1 10.1021/jm970101g
CHEMBL108142 20555 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 566 11 1 7 4.4 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccccc1 10.1021/jm970101g
11125029 24340 0 None None None Pig 8.9 pIC50 = 8.9 Binding
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 627 11 2 9 4.6 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C(=O)O)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm000538f
CHEMBL115147 24340 0 None None None Pig 8.9 pIC50 = 8.9 Binding
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 627 11 2 9 4.6 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C(=O)O)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm000538f
15453177 470356 0 None None None Human 8.9 pIC50 = 8.9 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 392 4 1 4 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL80857 470356 0 None None None Human 8.9 pIC50 = 8.9 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 392 4 1 4 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1Br 10.1016/0960-894X(96)00441-6
10790757 197526 0 None None None Human 8.9 pIC50 = 8.9 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 476 7 1 8 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(OC)c2)cc1 10.1021/jm9606507
CHEMBL268480 197526 0 None None None Human 8.9 pIC50 = 8.9 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 476 7 1 8 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(OC)c2)cc1 10.1021/jm9606507
10554273 23714 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 532 13 1 7 4.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)C1OCCO1 10.1021/jm980217s
CHEMBL111611 23714 0 None None None Rat 8.9 pIC50 = 8.9 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 532 13 1 7 4.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)C1OCCO1 10.1021/jm980217s
8260 1098 43 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsDisplacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cells
ChEMBL 479 8 1 9 3.9 COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 10.1016/j.bmcl.2016.06.014
9912992 1098 43 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsDisplacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cells
ChEMBL 479 8 1 9 3.9 COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 10.1016/j.bmcl.2016.06.014
CHEMBL3989834 1098 43 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsDisplacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cells
ChEMBL 479 8 1 9 3.9 COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 10.1016/j.bmcl.2016.06.014
18630945 335536 1 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 507 9 1 9 4.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OC 10.1016/j.bmcl.2016.06.014
CHEMBL4456288 335536 1 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 507 9 1 9 4.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OC 10.1016/j.bmcl.2016.06.014
155542285 347190 0 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 522 14 2 11 2.9 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1Oc1cccc(OC)c1 10.1016/j.bmcl.2016.06.014
CHEMBL4519822 347190 0 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 522 14 2 11 2.9 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1Oc1cccc(OC)c1 10.1016/j.bmcl.2016.06.014
216235 7338 38 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
3548 7338 38 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
3950 7338 38 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
CHEMBL282724 7338 38 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
DB06268 7338 38 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
22467234 176299 0 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 534 7 1 8 4.1 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(C)=O)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261599 176299 0 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 534 7 1 8 4.1 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(C)=O)ccc12 10.1007/s00044-004-0021-y
21041372 163129 0 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 687 14 2 12 3.6 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(N2CCOCC2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163725 163129 0 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 687 14 2 12 3.6 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(N2CCOCC2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
21041370 163429 0 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 636 13 2 10 4.4 COc1ccc(Cl)c(Oc2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)c1 10.1021/jm3009103
CHEMBL2165330 163429 0 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 636 13 2 10 4.4 COc1ccc(Cl)c(Oc2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)c1 10.1021/jm3009103
21979593 163432 0 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 590 11 2 8 4.3 O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Cl)cc1 10.1021/jm3009103
CHEMBL2165333 163432 0 None None None Human 8.9 pIC50 = 8.9 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 590 11 2 8 4.3 O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Cl)cc1 10.1021/jm3009103
44295177 38682 0 None None None Rat 8.9 pIC50 = 8.9 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 534 10 1 9 5.0 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1C 10.1016/s0960-894x(98)00301-1
CHEMBL1206680 38682 0 None None None Rat 8.9 pIC50 = 8.9 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 534 10 1 9 5.0 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1C 10.1016/s0960-894x(98)00301-1
104865 1454 67 None None None Rat 8.9 pIC50 = 8.9 Binding
In vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptorIn vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm0102304
3494 1454 67 None None None Rat 8.9 pIC50 = 8.9 Binding
In vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptorIn vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm0102304
392 1454 67 None None None Rat 8.9 pIC50 = 8.9 Binding
In vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptorIn vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm0102304
CHEMBL957 1454 67 None None None Rat 8.9 pIC50 = 8.9 Binding
In vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptorIn vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm0102304
DB00559 1454 67 None None None Rat 8.9 pIC50 = 8.9 Binding
In vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptorIn vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm0102304
10952199 24325 0 None None None Pig 8.9 pIC50 = 8.9 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 609 9 1 8 5.3 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(F)(F)F)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
CHEMBL115017 24325 0 None None None Pig 8.9 pIC50 = 8.9 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 609 9 1 8 5.3 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(F)(F)F)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
216235 7338 38 None None None Human 8.9 pIC50 = 8.9 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm9700068
3548 7338 38 None None None Human 8.9 pIC50 = 8.9 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm9700068
3950 7338 38 None None None Human 8.9 pIC50 = 8.9 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm9700068
CHEMBL282724 7338 38 None None None Human 8.9 pIC50 = 8.9 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm9700068
DB06268 7338 38 None None None Human 8.9 pIC50 = 8.9 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm9700068
216235 7338 38 None None None Human 8.9 pIC50 = 8.9 Binding
Inhibitory concentration towards Endothelin A receptor in humanInhibitory concentration towards Endothelin A receptor in human
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
3548 7338 38 None None None Human 8.9 pIC50 = 8.9 Binding
Inhibitory concentration towards Endothelin A receptor in humanInhibitory concentration towards Endothelin A receptor in human
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
3950 7338 38 None None None Human 8.9 pIC50 = 8.9 Binding
Inhibitory concentration towards Endothelin A receptor in humanInhibitory concentration towards Endothelin A receptor in human
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
CHEMBL282724 7338 38 None None None Human 8.9 pIC50 = 8.9 Binding
Inhibitory concentration towards Endothelin A receptor in humanInhibitory concentration towards Endothelin A receptor in human
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
DB06268 7338 38 None None None Human 8.9 pIC50 = 8.9 Binding
Inhibitory concentration towards Endothelin A receptor in humanInhibitory concentration towards Endothelin A receptor in human
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
216235 7338 38 None None None Human 8.9 pIC50 = 8.9 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm000349x
3548 7338 38 None None None Human 8.9 pIC50 = 8.9 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm000349x
3950 7338 38 None None None Human 8.9 pIC50 = 8.9 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm000349x
CHEMBL282724 7338 38 None None None Human 8.9 pIC50 = 8.9 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm000349x
DB06268 7338 38 None None None Human 8.9 pIC50 = 8.9 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm000349x
42630655 42267 0 None None None Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 557 11 2 7 5.5 CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1271586 42267 0 None None None Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 557 11 2 7 5.5 CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2010.08.074
11409462 411276 0 None None None Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 501 6 2 6 6.0 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(-c2ccccc2)c1 10.1021/jm030528p
CHEMBL58058 411276 0 None None None Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 501 6 2 6 6.0 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(-c2ccccc2)c1 10.1021/jm030528p
10505771 328339 0 None None None Rat 8.8 pIC50 = 8.8 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 506 12 1 4 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm010237l
CHEMBL419211 328339 0 None None None Rat 8.8 pIC50 = 8.8 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 506 12 1 4 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm010237l
11026025 467954 0 None None None Rat 8.8 pIC50 = 8.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 412 7 1 6 4.6 CCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL62669 467954 0 None None None Rat 8.8 pIC50 = 8.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 412 7 1 6 4.6 CCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
10649122 24043 0 None None None Rat 8.8 pIC50 = 8.8 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 502 12 1 4 5.2 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(F)c(F)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL113400 24043 0 None None None Rat 8.8 pIC50 = 8.8 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 502 12 1 4 5.2 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(F)c(F)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
10505771 328339 0 None None None Rat 8.8 pIC50 = 8.8 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 506 12 1 4 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL419211 328339 0 None None None Rat 8.8 pIC50 = 8.8 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 506 12 1 4 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
21041297 334177 0 None None None Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 510 12 2 9 3.4 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4436531 334177 0 None None None Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 510 12 2 9 3.4 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
71453357 163111 0 None None None Human 8.8 pIC50 = 8.8 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 707 12 1 12 5.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163708 163111 0 None None None Human 8.8 pIC50 = 8.8 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 707 12 1 12 5.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
159594 1080 38 None None None Rat 8.8 pIC50 = 8.8 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1016/s0960-894x(98)00301-1
3487 1080 38 None None None Rat 8.8 pIC50 = 8.8 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1016/s0960-894x(98)00301-1
CHEMBL9194 1080 38 None None None Rat 8.8 pIC50 = 8.8 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1016/s0960-894x(98)00301-1
DB06199 1080 38 None None None Rat 8.8 pIC50 = 8.8 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1016/s0960-894x(98)00301-1
44279303 216741 0 None None None Human 8.8 pIC50 = 8.8 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 576 11 2 7 4.3 COCCNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
CHEMBL31592 216741 0 None None None Human 8.8 pIC50 = 8.8 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 576 11 2 7 4.3 COCCNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
10302092 220843 0 None None None Rat 8.8 pIC50 = 8.8 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 532 12 1 7 3.7 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCC 10.1021/jm970101g
CHEMBL326861 220843 0 None None None Rat 8.8 pIC50 = 8.8 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 532 12 1 7 3.7 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCC 10.1021/jm970101g
10768903 26405 0 None None None Human 8.8 pIC50 = 8.8 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 544 11 2 6 5.3 CCCCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm990171i
CHEMBL1184133 26405 0 None None None Human 8.8 pIC50 = 8.8 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 544 11 2 6 5.3 CCCCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm990171i
11733231 467919 0 None None None Rat 8.8 pIC50 = 8.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 6 1 6 5.2 COc1cccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)c1 10.1021/jm010382z
CHEMBL62465 467919 0 None None None Rat 8.8 pIC50 = 8.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 6 1 6 5.2 COc1cccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)c1 10.1021/jm010382z
9872534 349996 0 None None None Rat 8.8 pIC50 = 8.8 Binding
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 521 11 2 10 3.5 COc1ccccc1Oc1c(NS(=O)(=O)/C=C/c2ccccc2)nc(-c2ncccn2)nc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL4590018 349996 0 None None None Rat 8.8 pIC50 = 8.8 Binding
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 521 11 2 10 3.5 COc1ccccc1Oc1c(NS(=O)(=O)/C=C/c2ccccc2)nc(-c2ncccn2)nc1OCCO 10.1016/j.bmcl.2016.06.014
44439103 182747 0 None None None Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 859 27 2 14 5.3 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCC(=O)N(C)Cc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2ccno2)cc1 10.1016/j.bmcl.2006.10.009
CHEMBL241460 182747 0 None None None Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 859 27 2 14 5.3 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCC(=O)N(C)Cc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2ccno2)cc1 10.1016/j.bmcl.2006.10.009
67952994 163433 23 None None None Human 8.8 pIC50 = 8.8 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 634 11 2 8 4.4 O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
CHEMBL2165334 163433 23 None None None Human 8.8 pIC50 = 8.8 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 634 11 2 8 4.4 O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
19689505 121698 0 None None None Pig 8.8 pIC50 = 8.8 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 639 11 1 8 6.5 CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(-c2ccc(C)cc2)c(OCCOc2ncc(Br)cn2)n1 10.1016/s0960-894x(01)00682-5
CHEMBL168904 121698 0 None None None Pig 8.8 pIC50 = 8.8 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 639 11 1 8 6.5 CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(-c2ccc(C)cc2)c(OCCOc2ncc(Br)cn2)n1 10.1016/s0960-894x(01)00682-5
44334065 332583 0 None None None Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 429 5 1 5 4.7 COc1ccc([C@@H]2c3nc(C4CC4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
CHEMBL430695 332583 0 None None None Human 8.8 pIC50 = 8.8 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 429 5 1 5 4.7 COc1ccc([C@@H]2c3nc(C4CC4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
10719367 198516 0 None None None Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 476 7 1 8 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)cc(OC)c2)cc1 10.1021/jm9606507
CHEMBL274359 198516 0 None None None Human 8.8 pIC50 = 8.8 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 476 7 1 8 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)cc(OC)c2)cc1 10.1021/jm9606507
12286 1953 39 None None None Human 8.8 pIC50 = 8.8 Binding
Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsDisplacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cells
ChEMBL 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
6433095 1953 39 None None None Human 8.8 pIC50 = 8.8 Binding
Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsDisplacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cells
ChEMBL 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
CHEMBL109648 1953 39 None None None Human 8.8 pIC50 = 8.8 Binding
Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsDisplacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cells
ChEMBL 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
DB06677 1953 39 None None None Human 8.8 pIC50 = 8.8 Binding
Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsDisplacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cells
ChEMBL 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
22467237 176291 0 None None None Human 8.8 pIC50 = 8.8 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 549 8 3 8 2.3 Cn1cc(C(C(=O)NS(=O)(=O)c2ccc(CC(=O)O)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1007/s00044-004-0021-y
CHEMBL2261357 176291 0 None None None Human 8.8 pIC50 = 8.8 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 549 8 3 8 2.3 Cn1cc(C(C(=O)NS(=O)(=O)c2ccc(CC(=O)O)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1007/s00044-004-0021-y
71455063 163124 0 None None None Human 8.8 pIC50 = 8.8 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 646 15 2 12 3.8 CCCCNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
CHEMBL2163720 163124 0 None None None Human 8.8 pIC50 = 8.8 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 646 15 2 12 3.8 CCCCNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
21041267 163436 20 None None None Human 8.8 pIC50 = 8.8 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 558 9 2 8 2.8 CNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
CHEMBL2165337 163436 20 None None None Human 8.8 pIC50 = 8.8 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 558 9 2 8 2.8 CNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
10813261 123194 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 8 1 6 4.4 COc1ccc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
CHEMBL175129 123194 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 8 1 6 4.4 COc1ccc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
9955200 23637 0 None None None Human 8.7 pIC50 = 8.7 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 446 6 1 7 3.8 COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
CHEMBL11115 23637 0 None None None Human 8.7 pIC50 = 8.7 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 446 6 1 7 3.8 COc1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
10601668 198715 0 None None None Human 8.7 pIC50 = 8.7 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)cc2OC)cc1 10.1021/jm9606507
CHEMBL275701 198715 0 None None None Human 8.7 pIC50 = 8.7 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)cc2OC)cc1 10.1021/jm9606507
10973523 467935 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 537 7 1 8 4.2 COc1ccc(C2=C(C(=O)NS(C)(=O)=O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL62578 467935 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 537 7 1 8 4.2 COc1ccc(C2=C(C(=O)NS(C)(=O)=O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
11122785 468031 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 8 1 6 4.6 COCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL63057 468031 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 8 1 6 4.6 COCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
10649546 218209 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 516 13 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1CCCCO1 10.1021/jm980217s
CHEMBL320569 218209 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 516 13 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1CCCCO1 10.1021/jm980217s
CHEMBL2304015 485317 0 None None None Pig 8.7 pIC50 = 8.7 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 634 6 6 6 1.0 Cc1[nH]c2ccccc2c1C[C@@H]1NC(=O)[C@@H](C2CC2)NC(=O)[C@H](C2CCCC2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC1=O 10.1021/jm9600914
10029171 199011 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 505 6 2 7 3.0 Cc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 10.1016/s0960-894x(01)00660-6
CHEMBL278109 199011 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 505 6 2 7 3.0 Cc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 10.1016/s0960-894x(01)00660-6
11800804 317351 0 None None None Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 550 10 4 5 4.7 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N(C)C2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL414605 317351 0 None None None Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 550 10 4 5 4.7 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N(C)C2CCCCC2)nc1C(=O)O 10.1021/jm9505932
42630655 42267 0 None None None Human 8.7 pIC50 = 8.7 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 557 11 2 7 5.5 CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL1271586 42267 0 None None None Human 8.7 pIC50 = 8.7 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 557 11 2 7 5.5 CCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
10504475 473885 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 468 8 1 6 3.4 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)CC(C)C)cc1 10.1021/jm9505369
CHEMBL9119 473885 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 468 8 1 6 3.4 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)CC(C)C)cc1 10.1021/jm9505369
71456863 163119 0 None None None Human 8.7 pIC50 = 8.7 Binding
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 680 14 2 12 4.2 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1016/j.bmcl.2016.06.014
CHEMBL2163716 163119 0 None None None Human 8.7 pIC50 = 8.7 Binding
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 680 14 2 12 4.2 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1016/j.bmcl.2016.06.014
10971938 468032 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 424 7 1 5 5.6 CC(C)CCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL63058 468032 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 424 7 1 5 5.6 CC(C)CCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
44315008 202887 0 None None None Pig 8.7 pIC50 = 8.7 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 665 13 5 5 4.7 CCSCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL305524 202887 0 None None None Pig 8.7 pIC50 = 8.7 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 665 13 5 5 4.7 CCSCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
71453356 163094 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 554 13 2 10 2.9 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1cccc(OC)c1 10.1021/jm3009103
CHEMBL2163691 163094 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 554 13 2 10 2.9 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1cccc(OC)c1 10.1021/jm3009103
71456863 163119 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 680 14 2 12 4.2 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163716 163119 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 680 14 2 12 4.2 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
11827768 24178 0 None None None Pig 8.7 pIC50 = 8.7 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 11 1 10 4.6 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncccn2)c1 10.1021/jm0102304
CHEMBL114201 24178 0 None None None Pig 8.7 pIC50 = 8.7 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 11 1 10 4.6 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ncccn2)c1 10.1021/jm0102304
44387543 123329 0 None None None Pig 8.7 pIC50 = 8.7 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 759 9 1 9 8.1 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(Cl)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1.O=C1C2=C(CCCC2)c2ccccc21 10.1021/jm0102304
CHEMBL175931 123329 0 None None None Pig 8.7 pIC50 = 8.7 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 759 9 1 9 8.1 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(Cl)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1.O=C1C2=C(CCCC2)c2ccccc21 10.1021/jm0102304
44334129 218160 0 None None None Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 459 8 1 5 5.5 CCCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
CHEMBL320208 218160 0 None None None Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 459 8 1 5 5.5 CCCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
10507467 22814 0 None None None Rat 8.0 pIC50 = 8 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 580 12 1 7 4.5 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)Cc1ccccc1 10.1021/jm970101g
CHEMBL109408 22814 0 None None None Rat 8.0 pIC50 = 8 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 580 12 1 7 4.5 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)Cc1ccccc1 10.1021/jm970101g
10118046 23740 0 None None None Rat 8.0 pIC50 = 8 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 504 10 1 7 2.9 CCCS(=O)(=O)N(C)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm970101g
CHEMBL111728 23740 0 None None None Rat 8.0 pIC50 = 8 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 504 10 1 7 2.9 CCCS(=O)(=O)N(C)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm970101g
10597575 21225 0 None None None Human 8.0 pIC50 = 8 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 408 5 1 6 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2CC2CCCC2)cc1 10.1021/jm9606507
CHEMBL10843 21225 0 None None None Human 8.0 pIC50 = 8 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 408 5 1 6 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2CC2CCCC2)cc1 10.1021/jm9606507
10671928 21596 0 None None None Human 8.0 pIC50 = 8 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 467 5 1 7 4.4 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2nccc3ccccc23)cc1 10.1021/jm9606507
CHEMBL10860 21596 0 None None None Human 8.0 pIC50 = 8 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 467 5 1 7 4.4 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2nccc3ccccc23)cc1 10.1021/jm9606507
10791988 22896 0 None None None Rat 8.0 pIC50 = 8 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 516 13 1 6 4.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1CCOCC1 10.1021/jm980217s
CHEMBL109474 22896 0 None None None Rat 8.0 pIC50 = 8 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 516 13 1 6 4.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1CCOCC1 10.1021/jm980217s
10792934 328877 0 None None None Human 8.0 pIC50 = 8 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 10 2 6 5.6 CCc1cc(CC)c(NC(=O)CN2C[C@H](c3ccc4c(c3)OCO4)[C@@H](C(=O)O)[C@@H]2c2ccc(OC)cc2)c(CC)c1 10.1021/jm990170q
CHEMBL420729 328877 0 None None None Human 8.0 pIC50 = 8 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 10 2 6 5.6 CCc1cc(CC)c(NC(=O)CN2C[C@H](c3ccc4c(c3)OCO4)[C@@H](C(=O)O)[C@@H]2c2ccc(OC)cc2)c(CC)c1 10.1021/jm990170q
9939960 349570 0 None None None Human 8.0 pIC50 = 8 Binding
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 704 13 2 11 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)cc(C(=O)N2CCN(C)CC2)cc1OCCOC(=O)Nc1ccccn1 10.1016/j.bmcl.2016.06.014
CHEMBL4579445 349570 0 None None None Human 8.0 pIC50 = 8 Binding
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 704 13 2 11 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)cc(C(=O)N2CCN(C)CC2)cc1OCCOC(=O)Nc1ccccn1 10.1016/j.bmcl.2016.06.014
127035070 273911 0 None None None Human 8.0 pIC50 = 8 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 647 11 2 7 7.3 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735931 273911 0 None None None Human 8.0 pIC50 = 8 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 647 11 2 7 7.3 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
127036865 274827 0 None None None Human 8.0 pIC50 = 8 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 584 10 3 7 5.7 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3753406 274827 0 None None None Human 8.0 pIC50 = 8 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 584 10 3 7 5.7 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
9875246 238977 0 None None None Pig 8.0 pIC50 = 8 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 733 15 2 12 6.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(SCCC(=O)O)nc1OCCOc1ncc(Br)cn1 10.1016/s0960-894x(01)00682-5
CHEMBL352775 238977 0 None None None Pig 8.0 pIC50 = 8 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 733 15 2 12 6.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(SCCC(=O)O)nc1OCCOc1ncc(Br)cn1 10.1016/s0960-894x(01)00682-5
10696210 199747 0 None None None Human 8.0 pIC50 = 8 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 483 6 2 9 3.7 CC(=O)c1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm9608366
CHEMBL283535 199747 0 None None None Human 8.0 pIC50 = 8 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 483 6 2 9 3.7 CC(=O)c1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm9608366
44291884 347018 0 None None None Human 8.0 pIC50 = 8 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 483 6 2 9 3.7 CC(=O)c1c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)ccc2c1OCO2 10.1021/jm9700068
CHEMBL45160 347018 0 None None None Human 8.0 pIC50 = 8 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 483 6 2 9 3.7 CC(=O)c1c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)ccc2c1OCO2 10.1021/jm9700068
10671037 259327 0 None None None Human 8.0 pIC50 = 8 Binding
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 446 8 1 6 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL369085 259327 0 None None None Human 8.0 pIC50 = 8 Binding
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 446 8 1 6 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm9606507
10673756 468476 0 None None None Human 8.0 pIC50 = 8 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 529 9 1 8 4.3 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCN3CCCC3)c2)cc1 10.1021/jm980504w
CHEMBL65939 468476 0 None None None Human 8.0 pIC50 = 8 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 529 9 1 8 4.3 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCN3CCCC3)c2)cc1 10.1021/jm980504w
10475644 468175 0 None None None Human 8.0 pIC50 = 8 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 392 5 1 6 3.2 COc1nc(Cl)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
CHEMBL6412 468175 0 None None None Human 8.0 pIC50 = 8 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 392 5 1 6 3.2 COc1nc(Cl)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
10696210 199747 0 None None None Human 8.0 pIC50 = 8 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 483 6 2 9 3.7 CC(=O)c1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm000349x
CHEMBL283535 199747 0 None None None Human 8.0 pIC50 = 8 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 483 6 2 9 3.7 CC(=O)c1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm000349x
71456862 163112 0 None None None Human 8.0 pIC50 = 8.0 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 651 12 1 12 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163709 163112 0 None None None Human 8.0 pIC50 = 8.0 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 651 12 1 12 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
44291583 201518 0 None None None Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 500 8 3 9 2.9 COc1cc(OC)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(N)=O)c1 10.1021/jm9608366
CHEMBL297215 201518 0 None None None Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 500 8 3 9 2.9 COc1cc(OC)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(N)=O)c1 10.1021/jm9608366
44278215 199757 0 None None None Human 7.0 pIC50 = 7 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 491 5 1 9 4.7 O=C(O)c1c(Sc2ccc3c(c2)OCO3)c2cc3c(cc2n1Cc1ccc2c(c1)OCO2)OCO3 10.1016/0960-894X(96)00232-6
CHEMBL283598 199757 0 None None None Human 7.0 pIC50 = 7 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 491 5 1 9 4.7 O=C(O)c1c(Sc2ccc3c(c2)OCO3)c2cc3c(cc2n1Cc1ccc2c(c1)OCO2)OCO3 10.1016/0960-894X(96)00232-6
10841576 25720 0 None None None Human 7.0 pIC50 = 7 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 620 11 2 6 6.3 CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1CC 10.1021/jm990171i
CHEMBL1180336 25720 0 None None None Human 7.0 pIC50 = 7 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 620 11 2 6 6.3 CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1CC 10.1021/jm990171i
CHEMBL94907 489416 0 None None None Human 7.0 pIC50 = 7 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 881 23 9 8 3.1 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
CHEMBL2304010 485312 0 None None None Pig 7.0 pIC50 = 7 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 676 7 6 7 1.6 CSC(C)(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Cl)[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC1=O 10.1021/jm9600914
10792316 333166 0 None None None Human 7.0 pIC50 = 7 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 530 8 2 6 5.3 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(C)cccc2C(C)C)cc1 10.1021/jm990170q
CHEMBL435185 333166 0 None None None Human 7.0 pIC50 = 7 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 530 8 2 6 5.3 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(C)cccc2C(C)C)cc1 10.1021/jm990170q
18738890 199370 0 None None None Human 7.0 pIC50 = 7 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 548 7 1 8 4.5 COC(=O)c1ccc2c(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)cn(C)c2c1 10.1016/s0960-894x(01)00660-6
CHEMBL281121 199370 0 None None None Human 7.0 pIC50 = 7 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 548 7 1 8 4.5 COC(=O)c1ccc2c(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)cn(C)c2c1 10.1016/s0960-894x(01)00660-6
23445498 473648 0 None None None Human 7.0 pIC50 = 7 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 426 4 1 5 4.9 Cc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(96)00496-9
CHEMBL89688 473648 0 None None None Human 7.0 pIC50 = 7 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 426 4 1 5 4.9 Cc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(96)00496-9
10265127 197162 1 None None None Rat 6.0 pIC50 = 6 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 270 3 1 4 2.2 Cc1noc(NS(=O)(=O)c2ccc(F)cc2)c1C 10.1021/jm00008a013
CHEMBL26522 197162 1 None None None Rat 6.0 pIC50 = 6 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 270 3 1 4 2.2 Cc1noc(NS(=O)(=O)c2ccc(F)cc2)c1C 10.1021/jm00008a013
CHEMBL315047 486597 0 None None None Human 6.0 pIC50 = 6 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 897 24 9 8 3.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
44327659 219379 0 None None None Human 6.0 pIC50 = 6 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 937 26 9 8 4.6 CCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)C(c1ccccc1)c1ccccc1 10.1021/jm00015a003
CHEMBL323331 219379 0 None None None Human 6.0 pIC50 = 6 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 937 26 9 8 4.6 CCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)C(c1ccccc1)c1ccccc1 10.1021/jm00015a003
CHEMBL318020 486619 0 None None None Human 6.0 pIC50 = 6 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 939 26 10 9 3.0 CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
44316685 469914 0 None None None Human 6.0 pIC50 = 6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 266 3 1 4 2.4 Cc1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1016/0960-894X(96)00441-6
CHEMBL77090 469914 0 None None None Human 6.0 pIC50 = 6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 266 3 1 4 2.4 Cc1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1016/0960-894X(96)00441-6
10022291 221516 0 None None None Rat 6.0 pIC50 = 6 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 374 9 1 3 5.1 O=C(O)CCC(C(=O)c1cccc(OCc2ccccc2)c1)c1ccccc1 10.1021/jm970847e
CHEMBL328964 221516 0 None None None Rat 6.0 pIC50 = 6 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 374 9 1 3 5.1 O=C(O)CCC(C(=O)c1cccc(OCc2ccccc2)c1)c1ccccc1 10.1021/jm970847e
12060119 219924 0 None None None Human 6.0 pIC50 = 6 Binding
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 441 7 2 6 3.9 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL324304 219924 0 None None None Human 6.0 pIC50 = 6 Binding
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 441 7 2 6 3.9 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)cc1 10.1016/j.bmcl.2016.06.014
4568158 220910 0 None None None Rat 6.0 pIC50 = 6 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 400 8 2 4 4.9 O=C(O)c1cc(-c2ccc(OCc3ccccc3)cc2OCc2ccccc2)[nH]n1 10.1021/jm9707131
CHEMBL327247 220910 0 None None None Rat 6.0 pIC50 = 6 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 400 8 2 4 4.9 O=C(O)c1cc(-c2ccc(OCc3ccccc3)cc2OCc2ccccc2)[nH]n1 10.1021/jm9707131
CHEMBL315047 486597 0 None None None Human 6.0 pIC50 = 6 Binding
Inhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cellsInhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cells
ChEMBL 897 24 9 8 3.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00095a029
10568280 468149 0 None None None Human 6.0 pIC50 = 6 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 328 4 1 5 2.5 CN(C)c1cccc2c(S(=O)(=O)Nc3cnccn3)cccc12 10.1021/jm9604585
CHEMBL6399 468149 0 None None None Human 6.0 pIC50 = 6 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 328 4 1 5 2.5 CN(C)c1cccc2c(S(=O)(=O)Nc3cnccn3)cccc12 10.1021/jm9604585
10553319 123829 0 None None None Rat 6.0 pIC50 = 6 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 496 11 5 4 3.8 CCN(CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C)[nH]1 10.1021/jm950592+
CHEMBL176430 123829 0 None None None Rat 6.0 pIC50 = 6 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 496 11 5 4 3.8 CCN(CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C)[nH]1 10.1021/jm950592+
10006086 239678 0 None None None Pig 5.0 pIC50 = 5 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 498 9 2 5 4.6 COc1ccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2c[nH]c3ccccc23)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
CHEMBL356916 239678 0 None None None Pig 5.0 pIC50 = 5 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 498 9 2 5 4.6 COc1ccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2c[nH]c3ccccc23)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
10381122 199416 0 None None None Rat 5.0 pIC50 = 5 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3ccc(N)cc3c2)c1C 10.1021/jm00008a013
CHEMBL281427 199416 0 None None None Rat 5.0 pIC50 = 5 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3ccc(N)cc3c2)c1C 10.1021/jm00008a013
44327466 196792 0 None None None Human 5.0 pIC50 = 5 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 966 25 9 8 5.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(C)(C)C)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL262229 196792 0 None None None Human 5.0 pIC50 = 5 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 966 25 9 8 5.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(C)(C)C)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
18617385 470070 0 None None None Human 5.0 pIC50 = 5 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 286 3 1 4 2.7 Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL78601 470070 0 None None None Human 5.0 pIC50 = 5 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 286 3 1 4 2.7 Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2)c1C 10.1016/0960-894X(96)00441-6
127029201 274663 0 None None None Human 5.0 pIC50 = 5 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 644 12 3 9 5.7 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3751994 274663 0 None None None Human 5.0 pIC50 = 5 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 644 12 3 9 5.7 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
3080568 352746 29 None None None Rat 5.0 pIC50 = 5 Binding
Displacement of endothelin-1 from ETA receptor in rat A10 cellsDisplacement of endothelin-1 from ETA receptor in rat A10 cells
ChEMBL 348 5 3 7 2.7 COC(=O)c1cc(O)cc(OC)c1Oc1cc(C)cc(O)c1C(=O)O 10.1021/np0102758
CHEMBL469424 352746 29 None None None Rat 5.0 pIC50 = 5 Binding
Displacement of endothelin-1 from ETA receptor in rat A10 cellsDisplacement of endothelin-1 from ETA receptor in rat A10 cells
ChEMBL 348 5 3 7 2.7 COC(=O)c1cc(O)cc(OC)c1Oc1cc(C)cc(O)c1C(=O)O 10.1021/np0102758
9846065 335463 0 None None None Human 5.0 pIC50 = 5 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 439 7 2 6 3.6 O=S(=O)(Nc1ncnc(OCCO)c1-c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4455096 335463 0 None None None Human 5.0 pIC50 = 5 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 439 7 2 6 3.6 O=S(=O)(Nc1ncnc(OCCO)c1-c1ccc(Cl)cc1)c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
44276947 216510 0 None None None Rat 5.0 pIC50 = 5 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 430 5 1 3 5.2 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc(Cl)c(Cl)c3)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144803 216510 0 None None None Rat 5.0 pIC50 = 5 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 430 5 1 3 5.2 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc(Cl)c(Cl)c3)c2=O)c1 10.1016/s0960-894x(00)00232-8
44276907 216514 0 None None None Rat 5.0 pIC50 = 5 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 376 4 1 4 3.6 O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1ccccc1 10.1016/s0960-894x(00)00232-8
CHEMBL3144845 216514 0 None None None Rat 5.0 pIC50 = 5 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 376 4 1 4 3.6 O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1ccccc1 10.1016/s0960-894x(00)00232-8
10381122 199416 0 None None None Rat 5.0 pIC50 = 5 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3ccc(N)cc3c2)c1C 10.1021/jm00004a012
CHEMBL281427 199416 0 None None None Rat 5.0 pIC50 = 5 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3ccc(N)cc3c2)c1C 10.1021/jm00004a012
3765218 468436 0 None None None Human 5.0 pIC50 = 5 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 419 4 1 4 4.2 Cc1nc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)ccc1Br 10.1021/jm9604585
CHEMBL6566 468436 0 None None None Human 5.0 pIC50 = 5 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 419 4 1 4 4.2 Cc1nc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)ccc1Br 10.1021/jm9604585
44266649 198404 0 None None None Human 5.0 pIC50 = 5 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 391 3 1 4 5.4 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc(Cl)ccc2n1-c1ccccc1 10.1016/0960-894X(96)00170-9
CHEMBL273488 198404 0 None None None Human 5.0 pIC50 = 5 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 391 3 1 4 5.4 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc(Cl)ccc2n1-c1ccccc1 10.1016/0960-894X(96)00170-9
23445421 122707 0 None None None Human 7.0 pIC50 = 7.0 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 454 6 1 5 5.0 Cc1ccc(CCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL173189 122707 0 None None None Human 7.0 pIC50 = 7.0 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 454 6 1 5 5.0 Cc1ccc(CCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
10832763 333128 0 None None None Human 5.0 pIC50 = 5.0 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 366 4 2 6 2.3 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)O)c1Br 10.1016/S0960-894X(97)00367-3
CHEMBL434983 333128 0 None None None Human 5.0 pIC50 = 5.0 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 366 4 2 6 2.3 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)O)c1Br 10.1016/S0960-894X(97)00367-3
137649809 313287 0 None None None Human 6.0 pIC50 = 6.0 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 583 10 2 7 5.9 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CCCC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4078297 313287 0 None None None Human 6.0 pIC50 = 6.0 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 583 10 2 7 5.9 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CCCC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
10527774 367022 0 None None None Human 7.0 pIC50 = 7.0 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 2 6 4.2 Cc1cccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1021/jm9608366
CHEMBL48031 367022 0 None None None Human 7.0 pIC50 = 7.0 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 2 6 4.2 Cc1cccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1021/jm9608366
22998456 122572 0 None None None Human 7.0 pIC50 = 7.0 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 514 8 1 8 4.9 CCCc1cc2c(cc1OCc1sccc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00132-7
CHEMBL172666 122572 0 None None None Human 7.0 pIC50 = 7.0 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 514 8 1 8 4.9 CCCc1cc2c(cc1OCc1sccc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00132-7
9874379 123213 0 None None None Human 6.0 pIC50 = 6.0 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 653 14 2 10 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL175268 123213 0 None None None Human 6.0 pIC50 = 6.0 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 653 14 2 10 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
10718385 473755 0 None None None Rat 7.0 pIC50 = 7.0 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 450 7 1 6 2.4 C#CCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9040 473755 0 None None None Rat 7.0 pIC50 = 7.0 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 450 7 1 6 2.4 C#CCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
23445593 123006 0 None None None Human 7.0 pIC50 = 7.0 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 440 6 1 5 4.7 Cc1ccc(CCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00133-9
CHEMBL174086 123006 0 None None None Human 7.0 pIC50 = 7.0 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 440 6 1 5 4.7 Cc1ccc(CCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00133-9
10805820 468707 41 None None None Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 322 4 2 6 2.2 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)O)c1Cl 10.1016/S0960-894X(97)00367-3
CHEMBL67664 468707 41 None None None Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 322 4 2 6 2.2 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)O)c1Cl 10.1016/S0960-894X(97)00367-3
10812400 198652 0 None None None Rat 7.0 pIC50 = 7.0 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 427 9 1 6 3.7 CCCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL275306 198652 0 None None None Rat 7.0 pIC50 = 7.0 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 427 9 1 6 3.7 CCCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
44265853 473369 0 None None None Rat 6.0 pIC50 = 6.0 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 454 4 1 6 2.7 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)N2CCOCC2)cc1 10.1021/jm9505369
CHEMBL8776 473369 0 None None None Rat 6.0 pIC50 = 6.0 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 454 4 1 6 2.7 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)N2CCOCC2)cc1 10.1021/jm9505369
10854399 468052 24 None None None Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 336 4 1 7 2.3 COC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1016/S0960-894X(97)00367-3
CHEMBL63169 468052 24 None None None Human 6.0 pIC50 = 6.0 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 336 4 1 7 2.3 COC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1016/S0960-894X(97)00367-3
10647020 124055 0 None None None Rat 8.0 pIC50 = 8.0 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 8 1 6 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1OC 10.1021/jm031041j
CHEMBL176696 124055 0 None None None Rat 8.0 pIC50 = 8.0 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 8 1 6 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1OC 10.1021/jm031041j
10647021 21303 0 None None None Human 8.0 pIC50 = 8.0 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 446 6 1 7 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1OC 10.1021/jm9606507
CHEMBL10846 21303 0 None None None Human 8.0 pIC50 = 8.0 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 446 6 1 7 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1OC 10.1021/jm9606507
10552548 198787 0 None None None Human 8.0 pIC50 = 8.0 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 476 7 1 8 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OC)c2OC)cc1 10.1021/jm9606507
CHEMBL276252 198787 0 None None None Human 8.0 pIC50 = 8.0 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 476 7 1 8 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OC)c2OC)cc1 10.1021/jm9606507
9934580 327951 0 None None None Human 8.0 pIC50 = 8.0 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 474 6 1 8 3.6 COC(=O)c1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
CHEMBL417428 327951 0 None None None Human 8.0 pIC50 = 8.0 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 474 6 1 8 3.6 COC(=O)c1ccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
127035757 273942 0 None None None Human 8.0 pIC50 = 8.0 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 591 10 1 8 6.2 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3736242 273942 0 None None None Human 8.0 pIC50 = 8.0 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 591 10 1 8 6.2 CCCCc1nn(-c2ccccc2Cl)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
76308472 176300 0 None None None Human 8.0 pIC50 = 8.0 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 517 6 1 8 3.7 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C#N)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261600 176300 0 None None None Human 8.0 pIC50 = 8.0 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 517 6 1 8 3.7 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C#N)ccc12 10.1007/s00044-004-0021-y
44320338 216629 0 None None None Rat 8.0 pIC50 = 8.0 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 490 7 2 6 5.0 O=C(O)c1ccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)cc1 10.1016/s0960-894x(00)00513-8
CHEMBL315087 216629 0 None None None Rat 8.0 pIC50 = 8.0 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 490 7 2 6 5.0 O=C(O)c1ccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)cc1 10.1016/s0960-894x(00)00513-8
44385162 124141 0 None None None Human 8.0 pIC50 = 8.0 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 533 10 2 10 3.3 C#CCOc1nc(-c2ccnc(CO)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL176963 124141 0 None None None Human 8.0 pIC50 = 8.0 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 533 10 2 10 3.3 C#CCOc1nc(-c2ccnc(CO)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10697633 123102 0 None None None Rat 8.0 pIC50 = 8.0 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 536 10 5 5 4.4 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL174448 123102 0 None None None Rat 8.0 pIC50 = 8.0 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 536 10 5 5 4.4 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm950592+
10697633 123102 0 None None None Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 536 10 5 5 4.4 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL174448 123102 0 None None None Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 536 10 5 5 4.4 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
10551548 255761 0 None None None Rat 7.0 pIC50 = 7.0 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 450 7 1 5 5.0 COc1ccc(C(=O)/C(Cc2ccc(Cl)cc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
CHEMBL366442 255761 0 None None None Rat 7.0 pIC50 = 7.0 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 450 7 1 5 5.0 COc1ccc(C(=O)/C(Cc2ccc(Cl)cc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
11732966 468211 0 None None None Rat 7.0 pIC50 = 7.0 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 444 5 1 5 5.6 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(C(C)C)cc32)cc1 10.1021/jm031041j
CHEMBL64244 468211 0 None None None Rat 7.0 pIC50 = 7.0 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 444 5 1 5 5.6 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(C(C)C)cc32)cc1 10.1021/jm031041j
CHEMBL302776 486414 0 None None None Pig 7.0 pIC50 = 7.0 Binding
Binding activity against Endothelin A receptor of Porcine aortic smooth muscle membranesBinding activity against Endothelin A receptor of Porcine aortic smooth muscle membranes
ChEMBL 584 7 7 6 0.3 CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00089a028
22616262 470373 0 None None None Human 7.0 pIC50 = 7.0 Binding
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 366 3 1 4 3.7 Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL80980 470373 0 None None None Human 7.0 pIC50 = 7.0 Binding
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 366 3 1 4 3.7 Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1Br 10.1016/0960-894X(96)00441-6
18617351 213828 0 None None None Human 7.0 pIC50 = 7.0 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 384 3 1 4 3.9 Cc1noc(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL309397 213828 0 None None None Human 7.0 pIC50 = 7.0 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 384 3 1 4 3.9 Cc1noc(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1Br 10.1016/0960-894X(96)00441-6
10433234 470291 0 None None None Human 7.0 pIC50 = 7.0 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 436 5 1 4 4.3 CCCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL80342 470291 0 None None None Human 7.0 pIC50 = 7.0 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 436 5 1 4 4.3 CCCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
11744509 19765 0 None None None Human 7.0 pIC50 = 7.0 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 450 5 1 6 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)cc2)cc1 10.1021/jm9606507
CHEMBL10733 19765 0 None None None Human 7.0 pIC50 = 7.0 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 450 5 1 6 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)cc2)cc1 10.1021/jm9606507
11732966 468211 0 None None None Rat 7.0 pIC50 = 7.0 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 444 5 1 5 5.6 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(C(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL64244 468211 0 None None None Rat 7.0 pIC50 = 7.0 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 444 5 1 5 5.6 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(C(C)C)cc32)cc1 10.1021/jm010382z
54587165 123079 0 None None None Pig 7.0 pIC50 = 7.0 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 675 15 5 4 5.9 CCCCCC[C@@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL1744023 123079 0 None None None Pig 7.0 pIC50 = 7.0 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 675 15 5 4 5.9 CCCCCC[C@@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
44293932 327502 0 None None None Human 7.0 pIC50 = 7.0 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 521 10 2 8 3.9 CCOc1ccc2c(c1)[C@H](c1cccc(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL417903 327502 0 None None None Human 7.0 pIC50 = 7.0 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 521 10 2 8 3.9 CCOc1ccc2c(c1)[C@H](c1cccc(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
15304942 329371 0 None None None Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 394 9 1 4 5.5 Cc1ccccc1C(CCC(=O)O)C(=O)c1cccc(OCc2ccsc2)c1 10.1021/jm9707131
CHEMBL421365 329371 0 None None None Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 394 9 1 4 5.5 Cc1ccccc1C(CCC(=O)O)C(=O)c1cccc(OCc2ccsc2)c1 10.1021/jm9707131
44213279 216507 0 None None None Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 456 6 1 5 4.2 COc1cccc(Cn2[nH]c(C(F)(F)C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144737 216507 0 None None None Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 456 6 1 5 4.2 COc1cccc(Cn2[nH]c(C(F)(F)C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
10554748 122850 0 None None None Rat 7.0 pIC50 = 7.0 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 552 10 6 6 3.3 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCC(O)CC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL173826 122850 0 None None None Rat 7.0 pIC50 = 7.0 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 552 10 6 6 3.3 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCC(O)CC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL335143 486942 0 None None None Pig 7.0 pIC50 = 7.0 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 584 7 7 6 0.3 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44382975 238998 0 None None None Human 6.0 pIC50 = 6.0 Binding
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 596 11 4 7 3.7 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NCc1nc(C(=O)O)cs1 10.1016/0960-894X(95)00144-I
CHEMBL352929 238998 0 None None None Human 6.0 pIC50 = 6.0 Binding
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 596 11 4 7 3.7 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NCc1nc(C(=O)O)cs1 10.1016/0960-894X(95)00144-I
10440821 474426 0 None None None Human 6.0 pIC50 = 6.0 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 918 24 9 8 4.1 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c(C)c(C)c(C)c(C)c1C)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL94689 474426 0 None None None Human 6.0 pIC50 = 6.0 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 918 24 9 8 4.1 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c(C)c(C)c(C)c(C)c1C)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10620470 221018 0 None None None Rat 6.0 pIC50 = 6.0 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 391 7 1 5 4.8 COc1cccc(/C(=C\c2cc(OCc3ccsc3)ccc2C#N)C(=O)O)c1 10.1021/jm970847e
CHEMBL327861 221018 0 None None None Rat 6.0 pIC50 = 6.0 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 391 7 1 5 4.8 COc1cccc(/C(=C\c2cc(OCc3ccsc3)ccc2C#N)C(=O)O)c1 10.1021/jm970847e
44293915 366020 0 None None None Human 6.0 pIC50 = 6.0 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 507 9 1 8 4.4 CCOc1ccc2c(c1)[C@H](c1cc(OC)c(OC)c(OC)c1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL52110 366020 0 None None None Human 6.0 pIC50 = 6.0 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 507 9 1 8 4.4 CCOc1ccc2c(c1)[C@H](c1cc(OC)c(OC)c(OC)c1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
44291495 25513 0 None None None Human 6.0 pIC50 = 6.0 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 6 2 9 3.6 Cc1noc(NS(=O)(=O)c2ccsc2/C(Cc2ccc3c(c2)OCO3)=N\O)c1Cl 10.1021/jm9700068
CHEMBL1178832 25513 0 None None None Human 6.0 pIC50 = 6.0 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 6 2 9 3.6 Cc1noc(NS(=O)(=O)c2ccsc2/C(Cc2ccc3c(c2)OCO3)=N\O)c1Cl 10.1021/jm9700068
44266565 198519 0 None None None Human 6.0 pIC50 = 6.0 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 417 5 1 6 4.7 COc1ccc(-c2c(C(=O)O)n(-c3ccc4c(c3)OCO4)c3ccc(OC)cc23)cc1 10.1016/0960-894X(96)00170-9
CHEMBL274370 198519 0 None None None Human 6.0 pIC50 = 6.0 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 417 5 1 6 4.7 COc1ccc(-c2c(C(=O)O)n(-c3ccc4c(c3)OCO4)c3ccc(OC)cc23)cc1 10.1016/0960-894X(96)00170-9
44311225 469595 0 None None None Human 6.0 pIC50 = 6.0 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 581 11 1 10 5.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)c1ccoc1 10.1016/S0960-894X(97)00400-9
CHEMBL74118 469595 0 None None None Human 6.0 pIC50 = 6.0 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 581 11 1 10 5.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)c1ccoc1 10.1016/S0960-894X(97)00400-9
13044638 176755 25 None None None Human 5.0 pIC50 = 5.0 Binding
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 206 2 1 3 2.4 COc1cccc2oc(C(=O)O)c(C)c12 10.1007/s00044-013-0542-3
CHEMBL2296888 176755 25 None None None Human 5.0 pIC50 = 5.0 Binding
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 206 2 1 3 2.4 COc1cccc2oc(C(=O)O)c(C)c12 10.1007/s00044-013-0542-3
CHEMBL269428 486293 0 None None None Human 5.0 pIC50 = 5.0 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 958 25 9 8 5.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10769177 222370 0 None None None Human 5.0 pIC50 = 5.0 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 11 2 6 5.2 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CCOC)cc1 10.1021/jm990170q
CHEMBL331066 222370 0 None None None Human 5.0 pIC50 = 5.0 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 11 2 6 5.2 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CCOC)cc1 10.1021/jm990170q
127026338 274807 0 None None None Human 5.0 pIC50 = 5.0 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 616 11 3 7 5.9 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3753277 274807 0 None None None Human 5.0 pIC50 = 5.0 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 616 11 3 7 5.9 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
120533 201747 7 None None None Rat 5.0 pIC50 = 5.0 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 379 3 2 5 2.0 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1I 10.1016/s0960-894x(00)00366-8
CHEMBL298976 201747 7 None None None Rat 5.0 pIC50 = 5.0 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 379 3 2 5 2.0 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1I 10.1016/s0960-894x(00)00366-8
10674532 333256 0 None None None Rat 5.0 pIC50 = 5.0 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 567 10 4 5 5.8 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C(C)C)s1 10.1021/jm950591h
CHEMBL435894 333256 0 None None None Rat 5.0 pIC50 = 5.0 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 567 10 4 5 5.8 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C(C)C)s1 10.1021/jm950591h
10452089 18910 0 None None None Human 5.0 pIC50 = 5.0 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 375 3 0 5 4.1 COC(=O)C(c1ccc2c(c1)OCO2)c1c2c(nc3ccccc13)CCCC2 10.1016/S0960-894X(96)00551-3
CHEMBL102494 18910 0 None None None Human 5.0 pIC50 = 5.0 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 375 3 0 5 4.1 COC(=O)C(c1ccc2c(c1)OCO2)c1c2c(nc3ccccc13)CCCC2 10.1016/S0960-894X(96)00551-3
10095637 103206 0 None None None Human 5.0 pIC50 = 5.0 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 457 9 1 5 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00186-W
CHEMBL15689 103206 0 None None None Human 5.0 pIC50 = 5.0 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 457 9 1 5 5.8 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccccc1 10.1016/0960-894X(95)00186-W
19385674 198849 0 None None None Human 5.0 pIC50 = 5.0 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 715 13 1 7 8.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cc(Br)c(OC)c(OC)c1Br 10.1016/0960-894X(95)00186-W
CHEMBL276819 198849 0 None None None Human 5.0 pIC50 = 5.0 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 715 13 1 7 8.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cc(Br)c(OC)c(OC)c1Br 10.1016/0960-894X(95)00186-W
19385674 198849 0 None None None Human 5.0 pIC50 = 5.0 Binding
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 715 13 1 7 8.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cc(Br)c(OC)c(OC)c1Br 10.1021/jm058225d
CHEMBL276819 198849 0 None None None Human 5.0 pIC50 = 5.0 Binding
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 715 13 1 7 8.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1cc(Br)c(OC)c(OC)c1Br 10.1021/jm058225d
44266538 19800 0 None None None Human 5.0 pIC50 = 5.0 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 371 4 1 4 4.8 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n1Cc1ccccc1 10.1016/0960-894X(96)00170-9
CHEMBL10750 19800 0 None None None Human 5.0 pIC50 = 5.0 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 371 4 1 4 4.8 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n1Cc1ccccc1 10.1016/0960-894X(96)00170-9
11798999 474470 0 None None None Rat 7.0 pIC50 = 7.0 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 482 7 1 6 3.8 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)CC(C)(C)C)cc1 10.1021/jm9505369
CHEMBL9495 474470 0 None None None Rat 7.0 pIC50 = 7.0 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 482 7 1 6 3.8 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)CC(C)(C)C)cc1 10.1021/jm9505369
71460536 163115 0 None None None Human 7.0 pIC50 = 7.0 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 589 11 1 12 3.1 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163712 163115 0 None None None Human 7.0 pIC50 = 7.0 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 589 11 1 12 3.1 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
10669120 474336 0 None None None Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 407 9 1 5 5.5 Cc1ccccc1[C@H](CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C#N 10.1021/jm9707131
CHEMBL94141 474336 0 None None None Rat 7.0 pIC50 = 7.0 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 407 9 1 5 5.5 Cc1ccccc1[C@H](CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C#N 10.1021/jm9707131
CHEMBL444274 488867 0 None None None Mouse 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL 896 26 10 9 1.9 CC[C@@H](C)[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/S0960-894X(01)81219-1
23445366 215862 0 None None None Human 6.9 pIC50 = 6.9 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 482 7 1 5 6.2 Cc1cc(CCC(C)C)ccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL313801 215862 0 None None None Human 6.9 pIC50 = 6.9 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 482 7 1 5 6.2 Cc1cc(CCC(C)C)ccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(96)00496-9
52949197 42284 0 None None None Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 555 10 2 7 5.1 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CC4)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1271746 42284 0 None None None Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 555 10 2 7 5.1 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CC4)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
10694591 23531 0 None None None Human 5.9 pIC50 = 5.9 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 444 6 1 6 4.6 CC(C)Oc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL11064 23531 0 None None None Human 5.9 pIC50 = 5.9 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 444 6 1 6 4.6 CC(C)Oc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
18184194 258468 0 None None None Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 712 15 2 12 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL368107 258468 0 None None None Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 712 15 2 12 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
9998577 198397 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 5 1 5 3.6 CCc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00008a013
CHEMBL27344 198397 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 5 1 5 3.6 CCc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00008a013
CHEMBL327350 486698 0 None None None Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cellsDisplacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cells
ChEMBL 879 24 8 7 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81215-4
18184228 124113 0 None None None Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 604 13 2 9 4.6 CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL176749 124113 0 None None None Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 604 13 2 9 4.6 CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
10342643 19496 0 None None None Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1C 10.1021/jm9606507
CHEMBL10588 19496 0 None None None Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1C 10.1021/jm9606507
10791694 198487 0 None None None Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(OC)c2OC)cc1 10.1021/jm9606507
CHEMBL274175 198487 0 None None None Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(OC)c2OC)cc1 10.1021/jm9606507
11058202 467902 0 None None None Rat 7.9 pIC50 = 7.9 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 388 4 1 5 4.4 CC(C)Oc1ccc2c(c1)C(Cl)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL62374 467902 0 None None None Rat 7.9 pIC50 = 7.9 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 388 4 1 5 4.4 CC(C)Oc1ccc2c(c1)C(Cl)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
11799636 218840 0 None None None Rat 7.9 pIC50 = 7.9 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 502 13 1 6 4.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1CCCO1 10.1021/jm980217s
CHEMBL321831 218840 0 None None None Rat 7.9 pIC50 = 7.9 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 502 13 1 6 4.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1CCCO1 10.1021/jm980217s
10626646 40334 0 None None None Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 11 2 6 5.8 CCCc1cccc(CCC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
CHEMBL123305 40334 0 None None None Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 11 2 6 5.8 CCCc1cccc(CCC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
10224745 222167 0 None None None Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 432 5 2 6 2.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 10.1016/j.bmcl.2016.06.014
CHEMBL330425 222167 0 None None None Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 432 5 2 6 2.4 Cc1cc(C)nc(O[C@H](C(=O)O)[C@@]2(c3ccccc3)NCC(=O)N(C)c3ccccc32)n1 10.1016/j.bmcl.2016.06.014
44459272 182052 0 None None None Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 491 6 2 7 2.6 Cn1cc(C(C(=O)NS(=O)(=O)c2ccccc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1016/s0960-894x(01)00660-6
CHEMBL24015 182052 0 None None None Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 491 6 2 7 2.6 Cn1cc(C(C(=O)NS(=O)(=O)c2ccccc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1016/s0960-894x(01)00660-6
22010352 236465 0 None None None Rat 7.9 pIC50 = 7.9 Binding
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 404 10 1 4 5.5 CC(=O)c1ccc(OCc2ccccc2)cc1OC(CCC(=O)O)c1ccccc1 10.1016/j.bmc.2015.01.003
CHEMBL3400984 236465 0 None None None Rat 7.9 pIC50 = 7.9 Binding
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 404 10 1 4 5.5 CC(=O)c1ccc(OCc2ccccc2)cc1OC(CCC(=O)O)c1ccccc1 10.1016/j.bmc.2015.01.003
10693270 122845 1 None None None Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
9931773 122845 1 None None None Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL173792 122845 1 None None None Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL2110231 122845 1 None None None Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
44295257 38534 0 None None None Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 538 10 1 9 4.8 COc1cc(F)ccc1C(=O)/C(Cc1cc(OC)c(OC)c(OC)c1)=C(\C(=O)O)c1ccc2nsnc2c1 10.1016/s0960-894x(98)00301-1
CHEMBL1205063 38534 0 None None None Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 538 10 1 9 4.8 COc1cc(F)ccc1C(=O)/C(Cc1cc(OC)c(OC)c(OC)c1)=C(\C(=O)O)c1ccc2nsnc2c1 10.1016/s0960-894x(98)00301-1
9915095 201653 0 None None None Human 7.9 pIC50 = 7.9 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 535 8 2 8 3.4 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCC(=O)O)N(C(=O)C(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL298212 201653 0 None None None Human 7.9 pIC50 = 7.9 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 535 8 2 8 3.4 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCC(=O)O)N(C(=O)C(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
10864618 232371 0 None None None Pig 7.9 pIC50 = 7.9 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 556 11 1 10 5.3 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2nccs2)c1 10.1021/jm0102304
CHEMBL331580 232371 0 None None None Pig 7.9 pIC50 = 7.9 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 556 11 1 10 5.3 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2nccs2)c1 10.1021/jm0102304
10599879 201406 0 None None None Human 7.9 pIC50 = 7.9 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 2 6 4.2 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9608366
CHEMBL296326 201406 0 None None None Human 7.9 pIC50 = 7.9 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 2 6 4.2 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9608366
10233400 256619 0 None None None Human 7.9 pIC50 = 7.9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccncc1 10.1016/s0960-894x(02)01084-3
CHEMBL366885 256619 0 None None None Human 7.9 pIC50 = 7.9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccncc1 10.1016/s0960-894x(02)01084-3
10304227 257923 0 None None None Human 7.9 pIC50 = 7.9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 603 10 2 13 4.2 C#CCOc1nc(-c2ccnc(-c3noc(S)n3)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL367686 257923 0 None None None Human 7.9 pIC50 = 7.9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 603 10 2 13 4.2 C#CCOc1nc(-c2ccnc(-c3noc(S)n3)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10745668 469287 0 None None None Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 572 10 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCCN3CCN(C)CC3)c2)cc1 10.1021/jm980504w
CHEMBL71787 469287 0 None None None Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 572 10 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCCN3CCN(C)CC3)c2)cc1 10.1021/jm980504w
CHEMBL148751 484699 0 None None None Mouse 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL 881 24 8 8 3.1 CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
CHEMBL137659 484668 0 None None None Pig 7.9 pIC50 = 7.9 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 624 8 6 6 1.2 CC[C@H](C)[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC1=O 10.1021/jm00021a021
44302513 202778 0 None None None Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 553 9 3 9 5.1 CCCc1c(O)c(C(C)=O)cc(C(C)=O)c1NC(=O)c1sc(C)cc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
CHEMBL304860 202778 0 None None None Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 553 9 3 9 5.1 CCCc1c(O)c(C(C)=O)cc(C(C)=O)c1NC(=O)c1sc(C)cc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm030528p
10623465 468737 0 None None None Human 7.9 pIC50 = 7.9 Binding
Inhibition of specific binding of [125-I] ET-1 to human Endothelin A receptorInhibition of specific binding of [125-I] ET-1 to human Endothelin A receptor
ChEMBL 450 6 1 6 3.7 CCN(C)c1cccc2c(S(=O)(=O)Nc3ncc(Br)nc3OC)cccc12 10.1021/jm9604585
CHEMBL6785 468737 0 None None None Human 7.9 pIC50 = 7.9 Binding
Inhibition of specific binding of [125-I] ET-1 to human Endothelin A receptorInhibition of specific binding of [125-I] ET-1 to human Endothelin A receptor
ChEMBL 450 6 1 6 3.7 CCN(C)c1cccc2c(S(=O)(=O)Nc3ncc(Br)nc3OC)cccc12 10.1021/jm9604585
18617303 215485 0 None None None Human 6.9 pIC50 = 6.9 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1cccc(S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/0960-894X(96)00441-6
CHEMBL312685 215485 0 None None None Human 6.9 pIC50 = 6.9 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1cccc(S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/0960-894X(96)00441-6
15453179 470322 0 None None None Human 6.9 pIC50 = 6.9 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 392 4 1 4 4.2 Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL80538 470322 0 None None None Human 6.9 pIC50 = 6.9 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 392 4 1 4 4.2 Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1Br 10.1016/0960-894X(96)00441-6
44293866 201739 0 None None None Human 6.9 pIC50 = 6.9 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 461 8 1 6 4.8 CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL298922 201739 0 None None None Human 6.9 pIC50 = 6.9 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 461 8 1 6 4.8 CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL292901 486389 0 None None None Pig 6.9 pIC50 = 6.9 Binding
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL 892 21 9 8 2.3 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
10627333 123150 0 None None None Rat 6.9 pIC50 = 6.9 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 595 11 4 8 4.2 COC(=O)C1(NC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc2cn(C)c3ccccc23)c2nc(C(=O)O)c(C)o2)CCCCC1 10.1021/jm950592+
CHEMBL174818 123150 0 None None None Rat 6.9 pIC50 = 6.9 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 595 11 4 8 4.2 COC(=O)C1(NC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc2cn(C)c3ccccc23)c2nc(C(=O)O)c(C)o2)CCCCC1 10.1021/jm950592+
CHEMBL335416 486943 0 None None None Pig 6.9 pIC50 = 6.9 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 624 9 6 6 1.4 CCCC[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC1=O 10.1021/jm00021a021
10961510 467911 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 458 7 1 4 6.6 COc1ccc(C2=C(C(=O)O)C(c3ccc(C(C)C)cc3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm031041j
CHEMBL62425 467911 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 458 7 1 4 6.6 COc1ccc(C2=C(C(=O)O)C(c3ccc(C(C)C)cc3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm031041j
44371449 102619 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 485 7 1 7 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)c(OC)c1 10.1016/s0960-894x(99)00040-2
CHEMBL156404 102619 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 485 7 1 7 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)c(OC)c1 10.1016/s0960-894x(99)00040-2
44371460 102771 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 469 5 1 7 4.9 COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc3c(c2)OCO3)c2oc3ccccc3c21 10.1016/s0960-894x(99)00040-2
CHEMBL156539 102771 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 469 5 1 7 4.9 COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc3c(c2)OCO3)c2oc3ccccc3c21 10.1016/s0960-894x(99)00040-2
10961510 467911 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 458 7 1 4 6.6 COc1ccc(C2=C(C(=O)O)C(c3ccc(C(C)C)cc3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL62425 467911 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 458 7 1 4 6.6 COc1ccc(C2=C(C(=O)O)C(c3ccc(C(C)C)cc3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
11733232 467938 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 7 1 6 5.2 CCCOc1cccc2c1C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL62586 467938 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 7 1 6 5.2 CCCOc1cccc2c1C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL412460 488220 0 None None None Rat 5.9 pIC50 = 5.9 Binding
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1670 33 22 23 -2.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
23445317 200699 0 None None None Human 5.9 pIC50 = 5.9 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 456 5 1 7 4.1 Cc1cccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/S0960-894X(97)00367-3
CHEMBL291404 200699 0 None None None Human 5.9 pIC50 = 5.9 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 456 5 1 7 4.1 Cc1cccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/S0960-894X(97)00367-3
23445507 122538 0 None None None Human 5.9 pIC50 = 5.9 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 442 6 1 6 4.5 Cc1ccc(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00132-7
CHEMBL172538 122538 0 None None None Human 5.9 pIC50 = 5.9 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 442 6 1 6 4.5 Cc1ccc(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00132-7
44298956 391309 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 489 9 1 7 4.8 CCOc1ccc2c(c1)c(-c1ccc(OC)cc1OC)c(C(=O)O)c(=O)n2Cc1ccccc1OC 10.1016/S0960-894X(97)00319-3
CHEMBL55666 391309 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 489 9 1 7 4.8 CCOc1ccc2c(c1)c(-c1ccc(OC)cc1OC)c(C(=O)O)c(=O)n2Cc1ccccc1OC 10.1016/S0960-894X(97)00319-3
10041979 199579 0 None None None Rat 4.9 pIC50 = 4.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 325 6 3 6 1.6 Cc1noc(NS(=O)(=O)c2ccc(NCC(=O)O)cc2)c1C 10.1021/jm00008a013
CHEMBL282557 199579 0 None None None Rat 4.9 pIC50 = 4.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 325 6 3 6 1.6 Cc1noc(NS(=O)(=O)c2ccc(NCC(=O)O)cc2)c1C 10.1021/jm00008a013
44266654 198368 0 None None None Human 4.9 pIC50 = 4.9 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 387 4 1 5 4.7 COc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2-c1ccccc1 10.1016/0960-894X(96)00170-9
CHEMBL273258 198368 0 None None None Human 4.9 pIC50 = 4.9 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 387 4 1 5 4.7 COc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2-c1ccccc1 10.1016/0960-894X(96)00170-9
44385576 259262 0 None None None Human 6.9 pIC50 = 6.9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 539 10 1 10 3.4 C#CCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL368929 259262 0 None None None Human 6.9 pIC50 = 6.9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 539 10 1 10 3.4 C#CCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
11799440 473908 0 None None None Rat 6.9 pIC50 = 6.9 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 496 11 1 6 4.3 CCCN(CCC)C(=O)CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9132 473908 0 None None None Rat 6.9 pIC50 = 6.9 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 496 11 1 6 4.3 CCCN(CCC)C(=O)CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
52949197 42284 0 None None None Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 555 10 2 7 5.1 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL1271746 42284 0 None None None Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 555 10 2 7 5.1 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
10531506 26387 0 None None None Human 6.9 pIC50 = 6.9 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 592 9 2 6 5.8 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2cc(C)ccc2C)cc1 10.1021/jm990171i
CHEMBL1184076 26387 0 None None None Human 6.9 pIC50 = 6.9 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 592 9 2 6 5.8 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2cc(C)ccc2C)cc1 10.1021/jm990171i
10650546 26391 0 None None None Human 5.9 pIC50 = 5.9 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 562 7 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC2c3ccccc3-c3ccccc32)cc1 10.1021/jm990171i
CHEMBL1184091 26391 0 None None None Human 5.9 pIC50 = 5.9 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 562 7 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC2c3ccccc3-c3ccccc32)cc1 10.1021/jm990171i
10814743 353262 0 None None None Human 6.9 pIC50 = 6.9 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 484 6 1 9 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C2(Cc3ccc4c(c3)OCO4)OCCO2)c1Cl 10.1021/jm9700068
CHEMBL47383 353262 0 None None None Human 6.9 pIC50 = 6.9 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 484 6 1 9 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C2(Cc3ccc4c(c3)OCO4)OCCO2)c1Cl 10.1021/jm9700068
10623888 328161 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 461 8 1 6 3.4 CCCCS(=O)(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL417971 328161 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 461 8 1 6 3.4 CCCCS(=O)(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10281573 122751 0 None None None Human 6.9 pIC50 = 6.9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 574 9 2 9 4.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ccncc2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL173358 122751 0 None None None Human 6.9 pIC50 = 6.9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 574 9 2 9 4.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ccncc2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
44385586 124420 0 None None None Human 6.9 pIC50 = 6.9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 531 10 1 9 4.7 C#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL177143 124420 0 None None None Human 6.9 pIC50 = 6.9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 531 10 1 9 4.7 C#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10645066 197507 0 None None None Human 6.9 pIC50 = 6.9 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 406 4 1 5 3.3 CN(C)c1cccc2c(S(=O)(=O)Nc3cnc(Br)cn3)cccc12 10.1021/jm9604585
CHEMBL268339 197507 0 None None None Human 6.9 pIC50 = 6.9 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 406 4 1 5 3.3 CN(C)c1cccc2c(S(=O)(=O)Nc3cnc(Br)cn3)cccc12 10.1021/jm9604585
11792960 317424 0 None None None Human 5.9 pIC50 = 5.9 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 361 4 1 4 3.8 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)nc3)cccc12 10.1021/jm9604585
CHEMBL415292 317424 0 None None None Human 5.9 pIC50 = 5.9 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 361 4 1 4 3.8 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)nc3)cccc12 10.1021/jm9604585
10593411 468461 0 None None None Human 5.9 pIC50 = 5.9 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 342 4 1 5 2.8 Cc1cnc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)cn1 10.1021/jm9604585
CHEMBL6583 468461 0 None None None Human 5.9 pIC50 = 5.9 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 342 4 1 5 2.8 Cc1cnc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)cn1 10.1021/jm9604585
127029202 274732 0 None None None Human 6.9 pIC50 = 6.9 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 598 11 3 7 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3752680 274732 0 None None None Human 6.9 pIC50 = 6.9 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 598 11 3 7 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
10122495 64508 0 None None None Human 5.9 pIC50 = 5.9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 665 12 1 10 6.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOCc1ccccc1 10.1016/s0960-894x(02)01084-3
CHEMBL139734 64508 0 None None None Human 5.9 pIC50 = 5.9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 665 12 1 10 6.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOCc1ccccc1 10.1016/s0960-894x(02)01084-3
44384177 238962 0 None None None Human 6.9 pIC50 = 6.9 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 506 6 1 8 4.6 Cc1noc(NS(=O)(=O)c2ccsc2COc2cc3c(cc2Cl)OCO3)c1Br 10.1016/S0960-894X(97)00132-7
CHEMBL352657 238962 0 None None None Human 6.9 pIC50 = 6.9 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 506 6 1 8 4.6 Cc1noc(NS(=O)(=O)c2ccsc2COc2cc3c(cc2Cl)OCO3)c1Br 10.1016/S0960-894X(97)00132-7
10550033 201496 0 None None None Human 5.9 pIC50 = 5.9 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 419 5 2 9 2.9 Cc1nnc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)s1 10.1021/jm9608366
CHEMBL297048 201496 0 None None None Human 5.9 pIC50 = 5.9 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 419 5 2 9 2.9 Cc1nnc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)s1 10.1021/jm9608366
10626521 122851 0 None None None Rat 4.9 pIC50 = 4.9 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 11 4 6 5.1 CCn1cc(C[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)c2nc(C(=O)O)c(C)o2)c2ccccc21 10.1021/jm950592+
CHEMBL173833 122851 0 None None None Rat 4.9 pIC50 = 4.9 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 11 4 6 5.1 CCn1cc(C[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)c2nc(C(=O)O)c(C)o2)c2ccccc21 10.1021/jm950592+
CHEMBL94983 489418 0 None None None Human 7.9 pIC50 = 7.9 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 924 26 10 9 2.9 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10671036 20986 0 None None None Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 446 6 1 7 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)c(OC)c1 10.1021/jm9606507
CHEMBL10834 20986 0 None None None Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 446 6 1 7 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)c(OC)c1 10.1021/jm9606507
9932004 198466 0 None None None Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 422 5 1 6 4.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2CC2CCCCC2)cc1 10.1021/jm9606507
CHEMBL273948 198466 0 None None None Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 422 5 1 6 4.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2CC2CCCCC2)cc1 10.1021/jm9606507
10816110 218172 0 None None None Rat 7.9 pIC50 = 7.9 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 532 13 1 7 4.2 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1OC(C)C(C)O1 10.1021/jm980217s
CHEMBL320254 218172 0 None None None Rat 7.9 pIC50 = 7.9 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 532 13 1 7 4.2 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1OC(C)C(C)O1 10.1021/jm980217s
44314619 469576 0 None None None Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL 631 12 5 4 4.5 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
CHEMBL73925 469576 0 None None None Human 7.9 pIC50 = 7.9 Binding
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL 631 12 5 4 4.5 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
10209324 38400 0 None None None Human 7.9 pIC50 = 7.9 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 546 8 1 7 6.2 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C)c1)C(=O)CCCC2 10.1039/C4MD00499J
CHEMBL12013 38400 0 None None None Human 7.9 pIC50 = 7.9 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 546 8 1 7 6.2 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C)c1)C(=O)CCCC2 10.1039/C4MD00499J
10740439 346878 0 None None None Human 7.9 pIC50 = 7.9 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 412 5 2 7 3.5 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)nc1 10.1021/jm9608366
CHEMBL45087 346878 0 None None None Human 7.9 pIC50 = 7.9 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 412 5 2 7 3.5 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)nc1 10.1021/jm9608366
135415889 122050 0 None None None Human 7.9 pIC50 = 7.9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 587 10 2 13 3.6 C#CCOc1nc(-c2ccnc(-c3noc(O)n3)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL170401 122050 0 None None None Human 7.9 pIC50 = 7.9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 587 10 2 13 3.6 C#CCOc1nc(-c2ccnc(-c3noc(O)n3)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10281943 122840 0 None None None Human 7.9 pIC50 = 7.9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 589 10 1 10 4.9 COCC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL173743 122840 0 None None None Human 7.9 pIC50 = 7.9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 589 10 1 10 4.9 COCC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10212088 197026 0 None None None Human 7.9 pIC50 = 7.9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 688 12 2 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
CHEMBL264035 197026 0 None None None Human 7.9 pIC50 = 7.9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 688 12 2 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
CHEMBL2370830 485621 0 None None None Pig 7.9 pIC50 = 7.9 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 624 7 6 6 1.2 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
42630531 42348 0 None None None Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 543 9 2 7 5.1 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OC(C)C)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1272299 42348 0 None None None Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 543 9 2 7 5.1 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OC(C)C)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
10768904 26401 0 None None None Human 7.9 pIC50 = 7.9 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 544 10 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(CC(C)C)c2ccccc2)cc1 10.1021/jm990171i
CHEMBL1184117 26401 0 None None None Human 7.9 pIC50 = 7.9 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 544 10 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(CC(C)C)c2ccccc2)cc1 10.1021/jm990171i
10385400 196559 0 None None None Rat 6.9 pIC50 = 6.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 385 4 1 5 3.4 Cc1noc(NS(=O)(=O)c2cccc3c(N4CCCC4=O)cccc23)c1C 10.1021/jm00008a013
CHEMBL26079 196559 0 None None None Rat 6.9 pIC50 = 6.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 385 4 1 5 3.4 Cc1noc(NS(=O)(=O)c2cccc3c(N4CCCC4=O)cccc23)c1C 10.1021/jm00008a013
10426828 198436 0 None None None Rat 6.9 pIC50 = 6.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 331 4 2 5 3.3 CNc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
CHEMBL27370 198436 0 None None None Rat 6.9 pIC50 = 6.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 331 4 2 5 3.3 CNc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
10361993 199765 0 None None None Rat 6.9 pIC50 = 6.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 373 5 1 5 4.1 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C(C)C)cccc23)c1C 10.1021/jm00008a013
CHEMBL283652 199765 0 None None None Rat 6.9 pIC50 = 6.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 373 5 1 5 4.1 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C(C)C)cccc23)c1C 10.1021/jm00008a013
11103224 466277 0 None None None Rat 6.9 pIC50 = 6.9 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 510 14 1 6 7.3 CCCCCCCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL61406 466277 0 None None None Rat 6.9 pIC50 = 6.9 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 510 14 1 6 7.3 CCCCCCCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
11826847 467983 0 None None None Rat 6.9 pIC50 = 6.9 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 8 1 6 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccccc1OC)O2 10.1021/jm010382z
CHEMBL62814 467983 0 None None None Rat 6.9 pIC50 = 6.9 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 8 1 6 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccccc1OC)O2 10.1021/jm010382z
10837347 23179 0 None None None Rat 6.9 pIC50 = 6.9 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 452 8 1 5 3.3 CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL109736 23179 0 None None None Rat 6.9 pIC50 = 6.9 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 452 8 1 5 3.3 CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
10298764 24157 0 None None None Rat 6.9 pIC50 = 6.9 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 468 8 1 6 3.2 CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL114084 24157 0 None None None Rat 6.9 pIC50 = 6.9 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 468 8 1 6 3.2 CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL317064 486607 14 None None None Human 6.9 pIC50 = 6.9 Binding
Inhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cellsInhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cells
ChEMBL 886 24 10 8 3.1 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00095a029
44266552 18860 0 None None None Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL10218 18860 0 None None None Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL337567 486991 0 None None None Pig 6.9 pIC50 = 6.9 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 644 10 7 7 1.1 CSCC[C@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](C(C)C)NC1=O 10.1021/jm00021a021
CHEMBL150719 484706 0 None None None Human 6.9 pIC50 = 6.9 Binding
The inhibitory constant was evaluated against Endothelin A receptor in rabbit renal artery tissueThe inhibitory constant was evaluated against Endothelin A receptor in rabbit renal artery tissue
ChEMBL 887 25 11 9 1.8 CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
44371421 104668 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 459 5 1 5 5.8 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3Cl)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL158204 104668 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 459 5 1 5 5.8 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3Cl)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
10067008 198103 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc2c1 10.1021/jm00008a013
CHEMBL27187 198103 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc2c1 10.1021/jm00008a013
10423091 200151 1 None None None Rat 5.9 pIC50 = 5.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2cccc(N)c2)c1C 10.1021/jm00008a013
CHEMBL286521 200151 1 None None None Rat 5.9 pIC50 = 5.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2cccc(N)c2)c1C 10.1021/jm00008a013
10552007 20653 0 None None None Human 5.9 pIC50 = 5.9 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 462 8 1 7 4.1 COc1ccc(C2(O)OC(=O)C(c3cc(OC)c(OC)c(OC)c3)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL10819 20653 0 None None None Human 5.9 pIC50 = 5.9 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 462 8 1 7 4.1 COc1ccc(C2(O)OC(=O)C(c3cc(OC)c(OC)c(OC)c3)=C2Cc2ccccc2)cc1 10.1021/jm9606507
10961720 468497 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 472 6 1 5 6.3 CC(C)Oc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(C(C)C)cc1)O2 10.1021/jm010382z
CHEMBL66094 468497 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 472 6 1 5 6.3 CC(C)Oc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(C(C)C)cc1)O2 10.1021/jm010382z
10577405 23956 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 502 14 1 5 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1C(C)(C)CCCC 10.1021/jm980217s
CHEMBL112777 23956 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 502 14 1 5 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1C(C)(C)CCCC 10.1021/jm980217s
10573912 221116 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 415 7 1 5 5.5 O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1[N+](=O)[O-])c1ccccc1Cl 10.1021/jm970847e
CHEMBL328444 221116 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 415 7 1 5 5.5 O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1[N+](=O)[O-])c1ccccc1Cl 10.1021/jm970847e
10524954 473985 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 399 6 1 5 4.5 N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1/C=C(/C(=O)O)c1ccccc1 10.1021/jm970847e
CHEMBL91741 473985 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 399 6 1 5 4.5 N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1/C=C(/C(=O)O)c1ccccc1 10.1021/jm970847e
44298343 201903 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 485 9 1 7 5.8 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC#N)c1 10.1016/s0960-894x(00)00366-8
CHEMBL300066 201903 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 485 9 1 7 5.8 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC#N)c1 10.1016/s0960-894x(00)00366-8
44298279 388919 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 502 10 1 7 5.8 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC(C)=O)c1 10.1016/s0960-894x(00)00366-8
CHEMBL54274 388919 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 502 10 1 7 5.8 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC(C)=O)c1 10.1016/s0960-894x(00)00366-8
155560344 123015 36 None None None Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]ET-1 from ET-A receptor in human SK-N-MC cells incubated for 4 hrs by gamma counting methodDisplacement of [125I]ET-1 from ET-A receptor in human SK-N-MC cells incubated for 4 hrs by gamma counting method
ChEMBL 641 12 4 7 4.8 CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/acs.jmedchem.5b01781
44283453 123015 36 None None None Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]ET-1 from ET-A receptor in human SK-N-MC cells incubated for 4 hrs by gamma counting methodDisplacement of [125I]ET-1 from ET-A receptor in human SK-N-MC cells incubated for 4 hrs by gamma counting method
ChEMBL 641 12 4 7 4.8 CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/acs.jmedchem.5b01781
5311032 123015 36 None None None Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]ET-1 from ET-A receptor in human SK-N-MC cells incubated for 4 hrs by gamma counting methodDisplacement of [125I]ET-1 from ET-A receptor in human SK-N-MC cells incubated for 4 hrs by gamma counting method
ChEMBL 641 12 4 7 4.8 CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/acs.jmedchem.5b01781
CHEMBL1741040 123015 36 None None None Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]ET-1 from ET-A receptor in human SK-N-MC cells incubated for 4 hrs by gamma counting methodDisplacement of [125I]ET-1 from ET-A receptor in human SK-N-MC cells incubated for 4 hrs by gamma counting method
ChEMBL 641 12 4 7 4.8 CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/acs.jmedchem.5b01781
CHEMBL37807 123015 36 None None None Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]ET-1 from ET-A receptor in human SK-N-MC cells incubated for 4 hrs by gamma counting methodDisplacement of [125I]ET-1 from ET-A receptor in human SK-N-MC cells incubated for 4 hrs by gamma counting method
ChEMBL 641 12 4 7 4.8 CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/acs.jmedchem.5b01781
CHEMBL4596821 123015 36 None None None Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]ET-1 from ET-A receptor in human SK-N-MC cells incubated for 4 hrs by gamma counting methodDisplacement of [125I]ET-1 from ET-A receptor in human SK-N-MC cells incubated for 4 hrs by gamma counting method
ChEMBL 641 12 4 7 4.8 CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/acs.jmedchem.5b01781
155535325 336536 0 None None None Human 5.9 pIC50 = 5.9 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 549 10 2 8 5.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)cc(-c2ncccn2)cc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL4471434 336536 0 None None None Human 5.9 pIC50 = 5.9 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 549 10 2 8 5.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)cc(-c2ncccn2)cc1OCCO 10.1016/j.bmcl.2016.06.014
44276946 216505 0 None None None Rat 5.9 pIC50 = 5.9 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 440 5 1 5 4.2 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3cc(Cl)c4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144735 216505 0 None None None Rat 5.9 pIC50 = 5.9 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 440 5 1 5 4.2 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3cc(Cl)c4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
44309897 469526 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 469 5 1 7 4.9 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccc4c(c3)OCO4)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(97)10151-2
CHEMBL73506 469526 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 469 5 1 7 4.9 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccc4c(c3)OCO4)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(97)10151-2
44298988 200865 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 459 8 1 6 4.8 CCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)c(=O)n2Cc1ccccc1OC 10.1016/S0960-894X(97)00319-3
CHEMBL292580 200865 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 459 8 1 6 4.8 CCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)c(=O)n2Cc1ccccc1OC 10.1016/S0960-894X(97)00319-3
10067008 198103 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc2c1 10.1021/jm00004a012
CHEMBL27187 198103 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc2c1 10.1021/jm00004a012
10423091 200151 1 None None None Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2cccc(N)c2)c1C 10.1021/jm00004a012
CHEMBL286521 200151 1 None None None Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2cccc(N)c2)c1C 10.1021/jm00004a012
44266595 18741 0 None None None Human 5.9 pIC50 = 5.9 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 507 6 1 7 6.0 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc(OCc3ccccc3)ccc2n1-c1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL10136 18741 0 None None None Human 5.9 pIC50 = 5.9 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 507 6 1 7 6.0 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc(OCc3ccccc3)ccc2n1-c1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
10337668 202229 0 None None None Human 4.9 pIC50 = 4.9 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 346 4 2 5 2.9 Cc1noc(NS(=O)(=O)c2cccc3c(C(=O)O)cccc23)c1C 10.1021/jm00029a001
CHEMBL30246 202229 0 None None None Human 4.9 pIC50 = 4.9 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 346 4 2 5 2.9 Cc1noc(NS(=O)(=O)c2cccc3c(C(=O)O)cccc23)c1C 10.1021/jm00029a001
4458 38359 47 None None None Rat 4.9 pIC50 = 4.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 309 3 1 6 1.6 CC(=O)N(c1onc(C)c1C)S(=O)(=O)c1ccc(N)cc1 10.1021/jm00008a013
6662 38359 47 None None None Rat 4.9 pIC50 = 4.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 309 3 1 6 1.6 CC(=O)N(c1onc(C)c1C)S(=O)(=O)c1ccc(N)cc1 10.1021/jm00008a013
CHEMBL1200910 38359 47 None None None Rat 4.9 pIC50 = 4.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 309 3 1 6 1.6 CC(=O)N(c1onc(C)c1C)S(=O)(=O)c1ccc(N)cc1 10.1021/jm00008a013
DB14033 38359 47 None None None Rat 4.9 pIC50 = 4.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 309 3 1 6 1.6 CC(=O)N(c1onc(C)c1C)S(=O)(=O)c1ccc(N)cc1 10.1021/jm00008a013
10337668 202229 0 None None None Rat 4.9 pIC50 = 4.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 346 4 2 5 2.9 Cc1noc(NS(=O)(=O)c2cccc3c(C(=O)O)cccc23)c1C 10.1021/jm00008a013
CHEMBL30246 202229 0 None None None Rat 4.9 pIC50 = 4.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 346 4 2 5 2.9 Cc1noc(NS(=O)(=O)c2cccc3c(C(=O)O)cccc23)c1C 10.1021/jm00008a013
18617314 470090 0 None None None Human 4.9 pIC50 = 4.9 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 334 3 1 4 2.7 Cc1noc(NS(=O)(=O)c2ccc(F)cc2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL78734 470090 0 None None None Human 4.9 pIC50 = 4.9 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 334 3 1 4 2.7 Cc1noc(NS(=O)(=O)c2ccc(F)cc2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL38071 487588 0 None None None Rat 4.9 pIC50 = 4.9 Binding
Compound was evaluated for the binding affinity to endothelin receptor in the rat heart ventricle.Compound was evaluated for the binding affinity to endothelin receptor in the rat heart ventricle.
ChEMBL 837 24 10 9 1.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00087a001
44213959 334922 0 None None None Human 4.9 pIC50 = 4.9 Binding
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 592 11 3 9 5.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(=O)Nc2ccccc2)nc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL4447655 334922 0 None None None Human 4.9 pIC50 = 4.9 Binding
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 592 11 3 9 5.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(=O)Nc2ccccc2)nc1OCCO 10.1016/j.bmcl.2016.06.014
127026027 274678 0 None None None Human 4.9 pIC50 = 4.9 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 628 12 3 8 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3752145 274678 0 None None None Human 4.9 pIC50 = 4.9 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 628 12 3 8 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL1791280 484829 0 None None None Human 4.9 pIC50 = 4.9 Binding
Inhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cellsInhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cells
ChEMBL 836 24 10 9 0.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00152-J
10816667 25721 0 None None None Human 6.9 pIC50 = 6.9 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 558 9 2 6 5.6 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(CC(C)(C)C)c2ccccc2)cc1 10.1021/jm990171i
CHEMBL1180341 25721 0 None None None Human 6.9 pIC50 = 6.9 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 558 9 2 6 5.6 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(CC(C)(C)C)c2ccccc2)cc1 10.1021/jm990171i
9853680 198901 0 None None None Human 5.9 pIC50 = 5.9 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 771 17 2 14 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL277275 198901 0 None None None Human 5.9 pIC50 = 5.9 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 771 17 2 14 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
10576378 201257 0 None None None Human 6.9 pIC50 = 6.9 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 471 6 2 7 3.9 COc1ccccc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Br 10.1021/jm9608366
CHEMBL295207 201257 0 None None None Human 6.9 pIC50 = 6.9 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 471 6 2 7 3.9 COc1ccccc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Br 10.1021/jm9608366
CHEMBL170229 484753 0 None None None Human 5.9 pIC50 = 5.9 Binding
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 569 12 4 5 3.8 CC(C)C[C@H](NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)N1CCCCCC1)C(=O)O 10.1016/0960-894X(95)00144-I
23445219 221959 0 None None None Human 5.9 pIC50 = 5.9 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 428 5 1 6 4.3 COc1cccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/S0960-894X(96)00496-9
CHEMBL329861 221959 0 None None None Human 5.9 pIC50 = 5.9 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 428 5 1 6 4.3 COc1cccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/S0960-894X(96)00496-9
44386163 123147 0 None None None Human 5.9 pIC50 = 5.9 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 577 14 2 10 3.4 CCCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL174781 123147 0 None None None Human 5.9 pIC50 = 5.9 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 577 14 2 10 3.4 CCCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
23445537 123905 0 None None None Human 6.9 pIC50 = 6.9 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 514 8 1 8 4.9 CCCc1cc2c(cc1OCc1ccsc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00132-7
CHEMBL176538 123905 0 None None None Human 6.9 pIC50 = 6.9 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 514 8 1 8 4.9 CCCc1cc2c(cc1OCc1ccsc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00132-7
10766067 24042 0 None None None Rat 6.9 pIC50 = 6.9 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 452 8 1 5 3.3 CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL113379 24042 0 None None None Rat 6.9 pIC50 = 6.9 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 452 8 1 5 3.3 CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
127035069 273843 0 None None None Human 6.9 pIC50 = 6.9 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 663 11 2 8 7.7 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735300 273843 0 None None None Human 6.9 pIC50 = 6.9 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 663 11 2 8 7.7 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
10792785 331535 0 None None None Rat 4.9 pIC50 = 4.9 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 3 6 5.0 CCOC(=O)c1nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)oc1C 10.1021/jm950592+
CHEMBL428298 331535 0 None None None Rat 4.9 pIC50 = 4.9 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 3 6 5.0 CCOC(=O)c1nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)oc1C 10.1021/jm950592+
9831527 257402 0 None None None Human 5.9 pIC50 = 5.9 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 698 14 2 12 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL367274 257402 0 None None None Human 5.9 pIC50 = 5.9 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 698 14 2 12 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
10189776 122833 0 None None None Human 6.9 pIC50 = 6.9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 651 11 1 10 6.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOc1ccccc1 10.1016/s0960-894x(02)01084-3
CHEMBL173689 122833 0 None None None Human 6.9 pIC50 = 6.9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 651 11 1 10 6.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOc1ccccc1 10.1016/s0960-894x(02)01084-3
10743478 218844 0 None None None Rat 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 484 12 1 4 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(F)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm031041j
CHEMBL321852 218844 0 None None None Rat 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 484 12 1 4 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(F)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm031041j
10504389 258570 0 None None None Rat 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 466 7 1 5 5.5 COc1ccc(C(=O)/C(Cc2cccc3ccccc23)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
CHEMBL368270 258570 0 None None None Rat 7.9 pIC50 = 7.9 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 466 7 1 5 5.5 COc1ccc(C(=O)/C(Cc2cccc3ccccc23)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
10505209 23622 0 None None None Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 490 6 1 9 3.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL11106 23622 0 None None None Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 490 6 1 9 3.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm9606507
10742841 197657 0 None None None Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 466 5 1 6 5.0 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc3ccccc3c2)cc1 10.1021/jm9606507
CHEMBL269453 197657 0 None None None Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 466 5 1 6 5.0 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc3ccccc3c2)cc1 10.1021/jm9606507
44314645 337183 0 None None None Pig 7.9 pIC50 = 7.9 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 601 13 5 4 4.7 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC1CC1)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL449962 337183 0 None None None Pig 7.9 pIC50 = 7.9 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 601 13 5 4 4.7 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC1CC1)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
10743478 218844 0 None None None Rat 7.9 pIC50 = 7.9 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 484 12 1 4 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(F)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL321852 218844 0 None None None Rat 7.9 pIC50 = 7.9 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 484 12 1 4 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(F)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
10166561 24365 0 None None None Human 7.9 pIC50 = 7.9 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 562 9 2 8 5.4 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CO)c1)C(=O)CCCC2 10.1039/C4MD00499J
CHEMBL11528 24365 0 None None None Human 7.9 pIC50 = 7.9 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 562 9 2 8 5.4 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CO)c1)C(=O)CCCC2 10.1039/C4MD00499J
44214320 176296 0 None None None Human 7.9 pIC50 = 7.9 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 510 6 1 7 4.0 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(F)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261364 176296 0 None None None Human 7.9 pIC50 = 7.9 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 510 6 1 7 4.0 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(F)ccc12 10.1007/s00044-004-0021-y
10240093 163116 0 None None None Human 7.9 pIC50 = 7.9 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 603 12 1 12 3.5 CCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
CHEMBL2163713 163116 0 None None None Human 7.9 pIC50 = 7.9 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 603 12 1 12 3.5 CCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
71458721 163130 0 None None None Human 7.9 pIC50 = 7.9 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 642 14 2 10 4.6 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(C2CC2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163726 163130 0 None None None Human 7.9 pIC50 = 7.9 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 642 14 2 10 4.6 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(C2CC2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
10812894 238945 0 None None None Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 437 7 1 6 4.7 N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1OC(C(=O)O)c1ccccc1Cl 10.1021/jm990378b
CHEMBL352536 238945 0 None None None Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 437 7 1 6 4.7 N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1OC(C(=O)O)c1ccccc1Cl 10.1021/jm990378b
17869371 38690 0 None None None Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 478 8 1 7 4.8 COc1ccc(C(=O)/C(Cc2ccc(OC)c(F)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1206716 38690 0 None None None Rat 7.9 pIC50 = 7.9 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 478 8 1 7 4.8 COc1ccc(C(=O)/C(Cc2ccc(OC)c(F)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
44293417 365883 0 None None None Human 7.9 pIC50 = 7.9 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 563 11 2 8 4.9 CCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1OCC(C)(C)C(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL49312 365883 0 None None None Human 7.9 pIC50 = 7.9 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 563 11 2 8 4.9 CCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1OCC(C)(C)C(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
101039204 1466 45 None None None Rat 7.9 pIC50 = 7.9 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm9707131
443289 1466 45 None None None Rat 7.9 pIC50 = 7.9 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm9707131
997 1466 45 None None None Rat 7.9 pIC50 = 7.9 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm9707131
CHEMBL314691 1466 45 None None None Rat 7.9 pIC50 = 7.9 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm9707131
CHEMBL4095638 1466 45 None None None Rat 7.9 pIC50 = 7.9 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm9707131
DB12054 1466 45 None None None Rat 7.9 pIC50 = 7.9 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm9707131
10814746 355441 0 None None None Human 7.9 pIC50 = 7.9 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 484 6 1 8 3.8 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
CHEMBL47706 355441 0 None None None Human 7.9 pIC50 = 7.9 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 484 6 1 8 3.8 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
10122675 198739 0 None None None Human 7.9 pIC50 = 7.9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 682 12 2 13 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
CHEMBL275897 198739 0 None None None Human 7.9 pIC50 = 7.9 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 682 12 2 13 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
CHEMBL1791271 484825 1 None None None Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cellsInhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cells
ChEMBL 923 25 9 8 4.2 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00152-J
9831249 122474 0 None None None Human 7.9 pIC50 = 7.9 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 672 14 2 10 6.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL172297 122474 0 None None None Human 7.9 pIC50 = 7.9 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 672 14 2 10 6.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
44311283 202415 0 None None None Human 7.9 pIC50 = 7.9 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 649 11 2 10 6.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)(C)C)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL303649 202415 0 None None None Human 7.9 pIC50 = 7.9 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 649 11 2 10 6.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)(C)C)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44320590 216226 0 None None None Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 556 10 2 9 4.8 COc1ccc(Cn2nc(-c3cccs3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c(OCC(=O)O)c1 10.1016/s0960-894x(00)00513-8
CHEMBL314206 216226 0 None None None Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 556 10 2 9 4.8 COc1ccc(Cn2nc(-c3cccs3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c(OCC(=O)O)c1 10.1016/s0960-894x(00)00513-8
CHEMBL1788127 486533 3 None None None Human 6.9 pIC50 = 6.9 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 923 25 9 8 4.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL313760 486533 3 None None None Human 6.9 pIC50 = 6.9 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 923 25 9 8 4.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
44382933 330005 0 None None None Human 6.9 pIC50 = 6.9 Binding
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 541 12 4 5 3.2 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NCCCC(=O)O 10.1016/0960-894X(95)00144-I
CHEMBL422720 330005 0 None None None Human 6.9 pIC50 = 6.9 Binding
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 541 12 4 5 3.2 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NCCCC(=O)O 10.1016/0960-894X(95)00144-I
CHEMBL330144 486733 0 None None None Human 6.9 pIC50 = 6.9 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 909 24 9 8 3.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(C)C 10.1021/jm00015a003
22616257 469881 0 None None None Human 6.9 pIC50 = 6.9 Binding
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 272 3 1 4 2.4 Cc1noc(NS(=O)(=O)c2ccccc2)c1Cl 10.1016/0960-894X(96)00441-6
CHEMBL76860 469881 0 None None None Human 6.9 pIC50 = 6.9 Binding
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 272 3 1 4 2.4 Cc1noc(NS(=O)(=O)c2ccccc2)c1Cl 10.1016/0960-894X(96)00441-6
44317109 214594 0 None None None Human 6.9 pIC50 = 6.9 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 472 3 1 4 4.1 Cc1noc(NS(=O)(=O)c2cc(Br)ccc2Br)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL311216 214594 0 None None None Human 6.9 pIC50 = 6.9 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 472 3 1 4 4.1 Cc1noc(NS(=O)(=O)c2cc(Br)ccc2Br)c1Br 10.1016/0960-894X(96)00441-6
18617327 470113 0 None None None Human 6.9 pIC50 = 6.9 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1ccccc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL78929 470113 0 None None None Human 6.9 pIC50 = 6.9 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1ccccc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
44276969 216498 0 None None None Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 506 7 1 5 4.8 COc1cccc(Cn2[nH]c(C(F)(F)C(F)(F)C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144607 216498 0 None None None Rat 6.9 pIC50 = 6.9 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 506 7 1 5 4.8 COc1cccc(Cn2[nH]c(C(F)(F)C(F)(F)C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
9961131 260038 0 None None None Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 650 15 2 12 3.1 CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL369676 260038 0 None None None Human 6.9 pIC50 = 6.9 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 650 15 2 12 3.1 CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL342617 487068 0 None None None Pig 6.9 pIC50 = 6.9 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 642 10 8 7 0.2 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL407639 487973 0 None None None Pig 6.9 pIC50 = 6.9 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 664 9 8 8 -0.8 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CS(=O)(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10381121 196585 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3ccc(N)cc23)c1C 10.1021/jm00008a013
CHEMBL26090 196585 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3ccc(N)cc23)c1C 10.1021/jm00008a013
9974856 199561 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2ccc3ccc(N(C)C)cc3c2)c1C 10.1021/jm00008a013
CHEMBL282401 199561 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2ccc3ccc(N(C)C)cc3c2)c1C 10.1021/jm00008a013
CHEMBL1790499 484802 0 None None None Pig 5.9 pIC50 = 5.9 Binding
Binding activity against Endothelin A receptor of Porcine aortic smooth muscle membranesBinding activity against Endothelin A receptor of Porcine aortic smooth muscle membranes
ChEMBL 612 9 7 6 1.1 CC[C@@H](C)[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC1=O 10.1021/jm00089a028
CHEMBL327350 486698 0 None None None Human 5.9 pIC50 = 5.9 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 879 24 8 7 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
18617355 469821 0 None None None Human 5.9 pIC50 = 5.9 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1ccc(S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/0960-894X(96)00441-6
CHEMBL76438 469821 0 None None None Human 5.9 pIC50 = 5.9 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1ccc(S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/0960-894X(96)00441-6
CHEMBL432683 488585 0 None None None Pig 5.9 pIC50 = 5.9 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscleCompound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscle
ChEMBL 598 8 7 6 0.7 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00087a001
10618969 474242 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 367 7 1 5 4.8 O=[N+]([O-])c1ccc(OCc2ccsc2)cc1/C=C(/CO)c1ccccc1 10.1021/jm970847e
CHEMBL93596 474242 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 367 7 1 5 4.8 O=[N+]([O-])c1ccc(OCc2ccsc2)cc1/C=C(/CO)c1ccccc1 10.1021/jm970847e
127034901 273916 0 None None None Human 5.9 pIC50 = 5.9 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 670 12 2 9 5.5 CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3736037 273916 0 None None None Human 5.9 pIC50 = 5.9 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 670 12 2 9 5.5 CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
44298382 389803 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 502 11 1 7 5.8 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCCC=O)c1 10.1016/s0960-894x(00)00366-8
CHEMBL54998 389803 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 502 11 1 7 5.8 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCCC=O)c1 10.1016/s0960-894x(00)00366-8
9974856 199561 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2ccc3ccc(N(C)C)cc3c2)c1C 10.1021/jm00004a012
CHEMBL282401 199561 0 None None None Rat 5.9 pIC50 = 5.9 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2ccc3ccc(N(C)C)cc3c2)c1C 10.1021/jm00004a012
CHEMBL343379 487091 0 None None None Pig 5.9 pIC50 = 5.9 Binding
Inhibitory effect against porcine Endothelin A receptorInhibitory effect against porcine Endothelin A receptor
ChEMBL 612 9 7 6 1.1 CC[C@H](C)[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC1=O 10.1021/jm00021a021
CHEMBL343379 487091 0 None None None Pig 5.9 pIC50 = 5.9 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 612 9 7 6 1.1 CC[C@H](C)[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC1=O 10.1021/jm00021a021
CHEMBL315780 486603 0 None None None Human 4.9 pIC50 = 4.9 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 850 23 8 9 3.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@H](C(=O)O)c1csc2ccccc12)[C@@H](C)CC 10.1021/jm00070a001
10334781 196366 0 None None None Human 4.9 pIC50 = 4.9 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 297 4 1 6 2.0 Cc1noc(NS(=O)(=O)c2cccc([N+](=O)[O-])c2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL25970 196366 0 None None None Human 4.9 pIC50 = 4.9 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 297 4 1 6 2.0 Cc1noc(NS(=O)(=O)c2cccc([N+](=O)[O-])c2)c1C 10.1016/0960-894X(96)00441-6
18617299 470130 0 None None None Human 4.9 pIC50 = 4.9 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 320 3 1 4 3.4 Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1C 10.1016/0960-894X(96)00441-6
CHEMBL79054 470130 0 None None None Human 4.9 pIC50 = 4.9 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 320 3 1 4 3.4 Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1C 10.1016/0960-894X(96)00441-6
127028930 274708 0 None None None Human 4.9 pIC50 = 4.9 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 570 9 3 7 6.0 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3752444 274708 0 None None None Human 4.9 pIC50 = 4.9 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 570 9 3 7 6.0 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
10769025 123039 0 None None None Rat 6.9 pIC50 = 6.9 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 550 10 5 5 4.6 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCC(C)CC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL174171 123039 0 None None None Rat 6.9 pIC50 = 6.9 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 550 10 5 5 4.6 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCC(C)CC2)nc1C(=O)O 10.1021/jm950592+
44384656 258009 0 None None None Human 6.9 pIC50 = 6.9 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 468 5 1 7 4.5 Cc1noc(NS(=O)(=O)c2ccsc2/C=C/c2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
CHEMBL367763 258009 0 None None None Human 6.9 pIC50 = 6.9 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 468 5 1 7 4.5 Cc1noc(NS(=O)(=O)c2ccsc2/C=C/c2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
10577111 473832 0 None None None Rat 4.9 pIC50 = 4.9 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 493 7 1 6 4.0 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)COc2ccc(F)cc2)cc1 10.1021/jm9505369
CHEMBL9084 473832 0 None None None Rat 4.9 pIC50 = 4.9 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 493 7 1 6 4.0 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)COc2ccc(F)cc2)cc1 10.1021/jm9505369
10723203 25727 0 None None None Human 4.9 pIC50 = 4.9 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 678 14 2 7 6.8 CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C 10.1021/jm990171i
CHEMBL1180350 25727 0 None None None Human 4.9 pIC50 = 4.9 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 678 14 2 7 6.8 CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C 10.1021/jm990171i
44291584 201365 0 None None None Human 5.8 pIC50 = 5.8 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 501 8 3 9 3.5 COc1cc(OC)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)O)c1 10.1021/jm9608366
CHEMBL296074 201365 0 None None None Human 5.8 pIC50 = 5.8 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 501 8 3 9 3.5 COc1cc(OC)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)O)c1 10.1021/jm9608366
10625875 257567 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 523 9 4 5 4.6 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
CHEMBL367313 257567 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 523 9 4 5 4.6 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
10625875 257567 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 523 9 4 5 4.6 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL367313 257567 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 523 9 4 5 4.6 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
22998447 473624 0 None None None Human 5.8 pIC50 = 5.8 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 414 5 1 6 4.4 Cc1noc(NS(=O)(=O)c2sccc2Oc2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL89457 473624 0 None None None Human 5.8 pIC50 = 5.8 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 414 5 1 6 4.4 Cc1noc(NS(=O)(=O)c2sccc2Oc2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
10381121 196585 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3ccc(N)cc23)c1C 10.1021/jm00004a012
CHEMBL26090 196585 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3ccc(N)cc23)c1C 10.1021/jm00004a012
10718688 366960 0 None None None Human 6.8 pIC50 = 6.8 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 457 5 3 7 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cccc(O)c2)c1Br 10.1021/jm9608366
CHEMBL48024 366960 0 None None None Human 6.8 pIC50 = 6.8 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 457 5 3 7 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cccc(O)c2)c1Br 10.1021/jm9608366
23445325 468405 0 None None None Human 6.8 pIC50 = 6.8 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 397 5 2 6 3.8 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1Cl 10.1016/S0960-894X(97)00367-3
CHEMBL65407 468405 0 None None None Human 6.8 pIC50 = 6.8 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 397 5 2 6 3.8 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1Cl 10.1016/S0960-894X(97)00367-3
10961546 197086 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm031041j
CHEMBL264543 197086 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm031041j
122272 197418 36 None None None Rat 7.8 pIC50 = 7.8 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00008a013
CHEMBL267458 197418 36 None None None Rat 7.8 pIC50 = 7.8 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00008a013
10961546 197086 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL264543 197086 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 6 1 6 5.2 COc1ccc(C2=C(C(=O)O)[C@H](c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
44283349 200491 0 None None None Pig 7.8 pIC50 = 7.8 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 603 13 5 4 5.0 CCCC[C@H](NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
44314751 200491 0 None None None Pig 7.8 pIC50 = 7.8 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 603 13 5 4 5.0 CCCC[C@H](NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL289410 200491 0 None None None Pig 7.8 pIC50 = 7.8 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 603 13 5 4 5.0 CCCC[C@H](NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL412602 200491 0 None None None Pig 7.8 pIC50 = 7.8 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 603 13 5 4 5.0 CCCC[C@H](NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
10602620 40476 0 None None None Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 544 10 2 6 5.4 CCCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
CHEMBL123997 40476 0 None None None Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 544 10 2 6 5.4 CCCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
10529868 329142 0 None None None Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 516 8 2 6 4.8 CCc1cccc(C)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
CHEMBL421073 329142 0 None None None Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 516 8 2 6 4.8 CCc1cccc(C)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
127035410 273830 0 None None None Human 7.8 pIC50 = 7.8 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 557 8 1 8 5.7 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C#N)c1)C(=O)CCCC2 10.1039/C4MD00499J
CHEMBL3735155 273830 0 None None None Human 7.8 pIC50 = 7.8 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 557 8 1 8 5.7 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C#N)c1)C(=O)CCCC2 10.1039/C4MD00499J
44320474 216716 0 None None None Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 440 8 1 5 5.7 CCC(CC)Cn1nc(-c2ccccc2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O 10.1016/s0960-894x(00)00513-8
CHEMBL315752 216716 0 None None None Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 440 8 1 5 5.7 CCC(CC)Cn1nc(-c2ccccc2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O 10.1016/s0960-894x(00)00513-8
10575845 25509 0 None None None Human 7.8 pIC50 = 7.8 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 457 7 2 8 3.8 COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(OC)c1 10.1021/jm9608366
CHEMBL1178807 25509 0 None None None Human 7.8 pIC50 = 7.8 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 457 7 2 8 3.8 COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(OC)c1 10.1021/jm9608366
10811595 199013 0 None None None Human 7.8 pIC50 = 7.8 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 411 5 2 6 4.1 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 10.1021/jm9608366
10811595 199013 0 None None None Human 7.8 pIC50 = 7.8 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 411 5 2 6 4.1 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 10.1021/jm9700068
CHEMBL278114 199013 0 None None None Human 7.8 pIC50 = 7.8 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 411 5 2 6 4.1 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 10.1021/jm9608366
CHEMBL278114 199013 0 None None None Human 7.8 pIC50 = 7.8 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 411 5 2 6 4.1 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 10.1021/jm9700068
CHEMBL328942 486724 0 None None None Human 7.8 pIC50 = 7.8 Binding
Inhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cellsInhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cells
ChEMBL 923 25 9 8 4.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00095a029
CHEMBL150719 484706 0 None None None Mouse 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL 887 25 11 9 1.8 CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
10360201 196048 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1onc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00004a012
CHEMBL25816 196048 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1onc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00004a012
122272 197418 36 None None None Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00004a012
CHEMBL267458 197418 36 None None None Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00004a012
44283349 200491 0 None None None Pig 7.8 pIC50 = 7.8 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 603 13 5 4 5.0 CCCC[C@H](NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
44314751 200491 0 None None None Pig 7.8 pIC50 = 7.8 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 603 13 5 4 5.0 CCCC[C@H](NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
CHEMBL289410 200491 0 None None None Pig 7.8 pIC50 = 7.8 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 603 13 5 4 5.0 CCCC[C@H](NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
CHEMBL412602 200491 0 None None None Pig 7.8 pIC50 = 7.8 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 603 13 5 4 5.0 CCCC[C@H](NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
44334053 18897 0 None None None Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 465 5 1 5 5.5 COc1ccc([C@@H]2c3nc(-c4ccccc4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
CHEMBL102411 18897 0 None None None Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 465 5 1 5 5.5 COc1ccc([C@@H]2c3nc(-c4ccccc4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
10811595 199013 0 None None None Human 7.8 pIC50 = 7.8 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 411 5 2 6 4.1 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 10.1021/jm000349x
CHEMBL278114 199013 0 None None None Human 7.8 pIC50 = 7.8 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 411 5 2 6 4.1 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 10.1021/jm000349x
CHEMBL336563 486977 0 None None None Pig 7.8 pIC50 = 7.8 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 624 6 6 6 1.2 CC(C)C[C@H]1NC(=O)[C@H](C(C)(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL347948 487105 0 None None None Human 7.8 pIC50 = 7.8 Binding
The inhibitory constant was evaluated against Endothelin A receptorThe inhibitory constant was evaluated against Endothelin A receptor
ChEMBL 831 21 8 8 2.0 CC[C@H](C)[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81219-1
11072080 26375 0 None None None Pig 7.8 pIC50 = 7.8 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 600 11 1 9 6.4 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ccc3ccccc3n2)c1 10.1021/jm0102304
CHEMBL1183970 26375 0 None None None Pig 7.8 pIC50 = 7.8 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 600 11 1 9 6.4 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ccc3ccccc3n2)c1 10.1021/jm0102304
155562688 349198 0 None None None Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 554 13 2 10 2.9 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
CHEMBL4570529 349198 0 None None None Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 554 13 2 10 2.9 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
22616258 215101 0 None None None Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 372 5 1 4 3.8 CCCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C 10.1016/0960-894X(96)00441-6
CHEMBL311781 215101 0 None None None Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 372 5 1 4 3.8 CCCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C 10.1016/0960-894X(96)00441-6
10740943 468424 0 None None None Human 7.8 pIC50 = 7.8 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 422 5 2 6 3.2 CNc1cccc2c(S(=O)(=O)Nc3ncc(Br)nc3OC)cccc12 10.1021/jm9604585
CHEMBL6555 468424 0 None None None Human 7.8 pIC50 = 7.8 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 422 5 2 6 3.2 CNc1cccc2c(S(=O)(=O)Nc3ncc(Br)nc3OC)cccc12 10.1021/jm9604585
CHEMBL67074 461727 0 None None None Pig 7.8 pIC50 = 7.8 Binding
Tested for its ability to inhibit the binding of [125I]ET1 to the Endothelin A receptor in porcine thoracic aorta membranes.Tested for its ability to inhibit the binding of [125I]ET1 to the Endothelin A receptor in porcine thoracic aorta membranes.
ChEMBL 646 8 2 13 5.8 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC(=O)C2=C(C)N=C(C)/C(=C(/O)OC)[C@@H]2c2cccc([N+](=O)[O-])c2)[C@@H]1c1cccc([N+](=O)[O-])c1 10.1016/S0960-894X(01)81025-8
122272 197418 36 None None None Human 6.8 pIC50 = 6.8 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00029a001
CHEMBL267458 197418 36 None None None Human 6.8 pIC50 = 6.8 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00029a001
10095393 197861 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 452 5 3 5 5.3 Cc1noc(NS(=O)(=O)c2cccc3c(N/C(S)=N/c4ccccc4)cccc23)c1C 10.1021/jm00008a013
CHEMBL27063 197861 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 452 5 3 5 5.3 Cc1noc(NS(=O)(=O)c2cccc3c(N/C(S)=N/c4ccccc4)cccc23)c1C 10.1021/jm00008a013
10576863 22604 0 None None None Human 6.8 pIC50 = 6.8 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 484 5 1 6 5.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)c(Cl)c2)cc1 10.1021/jm9606507
CHEMBL10926 22604 0 None None None Human 6.8 pIC50 = 6.8 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 484 5 1 6 5.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(Cl)c(Cl)c2)cc1 10.1021/jm9606507
44279338 216355 0 None None None Pig 6.8 pIC50 = 6.8 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 487 11 6 4 2.3 CC(C)C[C@H](NC(=O)NC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31436 216355 0 None None None Pig 6.8 pIC50 = 6.8 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 487 11 6 4 2.3 CC(C)C[C@H](NC(=O)NC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
44279309 317335 0 None None None Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 412 3 2 3 4.5 Cc1ccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)cc1 10.1016/0960-894X(95)00230-Q
CHEMBL414408 317335 0 None None None Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 412 3 2 3 4.5 Cc1ccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)cc1 10.1016/0960-894X(95)00230-Q
10641986 474140 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 356 6 1 4 4.2 N#Cc1ccc(OCc2cccnc2)cc1/C=C(/C(=O)O)c1ccccc1 10.1021/jm970847e
CHEMBL92842 474140 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 356 6 1 4 4.2 N#Cc1ccc(OCc2cccnc2)cc1/C=C(/C(=O)O)c1ccccc1 10.1021/jm970847e
44266646 198827 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 475 6 1 8 4.5 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/s0960-894x(97)10151-2
CHEMBL276638 198827 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 475 6 1 8 4.5 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/s0960-894x(97)10151-2
10087191 201944 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3c(N)cccc23)c1C 10.1021/jm00004a012
CHEMBL30039 201944 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3c(N)cccc23)c1C 10.1021/jm00004a012
CHEMBL424227 488443 0 None None None Pig 6.8 pIC50 = 6.8 Binding
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL 835 19 8 7 3.0 CC[C@H](C)[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
44334084 219218 0 None None None Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 461 7 2 6 3.8 COc1ccc([C@@H]2c3nc(CCC(=O)O)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
CHEMBL322434 219218 0 None None None Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 461 7 2 6 3.8 COc1ccc([C@@H]2c3nc(CCC(=O)O)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
122272 197418 36 None None None Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm030480f
CHEMBL267458 197418 36 None None None Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm030480f
44266646 198827 0 None None None Human 6.8 pIC50 = 6.8 Binding
Potency at Endothelin A receptor was determinedPotency at Endothelin A receptor was determined
ChEMBL 475 6 1 8 4.5 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1021/jm0300429
CHEMBL276638 198827 0 None None None Human 6.8 pIC50 = 6.8 Binding
Potency at Endothelin A receptor was determinedPotency at Endothelin A receptor was determined
ChEMBL 475 6 1 8 4.5 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1021/jm0300429
CHEMBL137671 484669 0 None None None Pig 6.8 pIC50 = 6.8 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 669 11 9 7 -0.6 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL335128 486941 0 None None None Pig 6.8 pIC50 = 6.8 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 699 9 8 6 2.0 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44371429 102146 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 455 6 1 6 5.2 COc1cccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)c1 10.1016/s0960-894x(99)00040-2
CHEMBL155973 102146 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 455 6 1 6 5.2 COc1cccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)c1 10.1016/s0960-894x(99)00040-2
44316993 469808 0 None None None Human 5.8 pIC50 = 5.8 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 286 3 1 4 2.7 Cc1noc(NS(=O)(=O)c2cccc(Cl)c2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL76360 469808 0 None None None Human 5.8 pIC50 = 5.8 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 286 3 1 4 2.7 Cc1noc(NS(=O)(=O)c2cccc(Cl)c2)c1C 10.1016/0960-894X(96)00441-6
10983585 347375 0 None None None Human 5.8 pIC50 = 5.8 Binding
Binding affinity to recombinant human ETABinding affinity to recombinant human ETA
ChEMBL 473 9 2 8 3.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCO 10.1021/acs.jmedchem.0c01093
CHEMBL4525321 347375 0 None None None Human 5.8 pIC50 = 5.8 Binding
Binding affinity to recombinant human ETABinding affinity to recombinant human ETA
ChEMBL 473 9 2 8 3.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCO 10.1021/acs.jmedchem.0c01093
10650477 233270 0 None None None Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 10 2 6 5.8 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC(C)C)cc1 10.1021/jm990170q
CHEMBL333009 233270 0 None None None Human 5.8 pIC50 = 5.8 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 10 2 6 5.8 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC(C)C)cc1 10.1021/jm990170q
44298356 389528 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 503 10 2 8 5.7 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCC/C=N/O)c1 10.1016/s0960-894x(00)00366-8
CHEMBL54703 389528 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 503 10 2 8 5.7 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCC/C=N/O)c1 10.1016/s0960-894x(00)00366-8
10983585 347375 0 None None None Human 5.8 pIC50 = 5.8 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 473 9 2 8 3.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL4525321 347375 0 None None None Human 5.8 pIC50 = 5.8 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 473 9 2 8 3.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCO 10.1016/j.bmcl.2016.06.014
66875612 349284 0 None None None Human 5.8 pIC50 = 5.8 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 495 10 2 10 2.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL4572634 349284 0 None None None Human 5.8 pIC50 = 5.8 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 495 10 2 10 2.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccccc2)nc(-c2ncccn2)nc1OCCO 10.1016/j.bmcl.2016.06.014
10693981 122329 0 None None None Rat 5.8 pIC50 = 5.8 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 431 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL171702 122329 0 None None None Rat 5.8 pIC50 = 5.8 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 431 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
15340612 216491 1 None None None Rat 5.8 pIC50 = 5.8 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 406 5 1 5 3.6 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144599 216491 1 None None None Rat 5.8 pIC50 = 5.8 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 406 5 1 5 3.6 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
10744921 122829 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 536 10 5 4 4.6 CCc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
CHEMBL173666 122829 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 536 10 5 4 4.6 CCc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
44299023 393474 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 457 6 1 6 4.7 CCc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)c(=O)n2Cc1ccccc1OC 10.1016/S0960-894X(97)00319-3
CHEMBL56343 393474 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 457 6 1 6 4.7 CCc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)c(=O)n2Cc1ccccc1OC 10.1016/S0960-894X(97)00319-3
44332577 19046 0 None None None Human 5.8 pIC50 = 5.8 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 341 3 0 4 4.4 O=CC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL103484 19046 0 None None None Human 5.8 pIC50 = 5.8 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 341 3 0 4 4.4 O=CC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
44266540 19244 0 None None None Human 5.8 pIC50 = 5.8 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 447 6 1 7 4.8 COc1ccc2c(c1)c(-c1ccc(OC)c(OC)c1)c(C(=O)O)n2-c1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL10457 19244 0 None None None Human 5.8 pIC50 = 5.8 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 447 6 1 7 4.8 COc1ccc2c(c1)c(-c1ccc(OC)c(OC)c1)c(C(=O)O)n2-c1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
44266549 317860 0 None None None Human 5.8 pIC50 = 5.8 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 415 4 1 6 4.5 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n1Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL416518 317860 0 None None None Human 5.8 pIC50 = 5.8 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 415 4 1 6 4.5 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n1Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
19432649 469390 0 None None None Human 5.8 pIC50 = 5.8 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 487 9 2 8 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCO 10.1016/S0960-894X(97)00400-9
CHEMBL72473 469390 0 None None None Human 5.8 pIC50 = 5.8 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 487 9 2 8 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCO 10.1016/S0960-894X(97)00400-9
CHEMBL342215 487055 0 None None None Pig 5.8 pIC50 = 5.8 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 710 7 5 9 2.1 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2cn(C(=O)OC(C)(C)C)c3ccccc23)NC1=O 10.1021/jm00021a021
44279349 332871 0 None None None Human 4.8 pIC50 = 4.8 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 448 3 2 3 5.3 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3cccc4ccccc34)cc21 10.1016/0960-894X(95)00230-Q
CHEMBL433039 332871 0 None None None Human 4.8 pIC50 = 4.8 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 448 3 2 3 5.3 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3cccc4ccccc34)cc21 10.1016/0960-894X(95)00230-Q
CHEMBL336087 486970 0 None None None Pig 4.8 pIC50 = 4.8 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 587 7 6 7 0.1 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O 10.1021/jm00021a021
44386537 255754 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 532 10 4 7 4.2 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2cccnc2)nc1C(=O)O 10.1021/jm950592+
CHEMBL366391 255754 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 532 10 4 7 4.2 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2cccnc2)nc1C(=O)O 10.1021/jm950592+
10188517 124518 0 None None None Human 6.8 pIC50 = 6.8 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 582 9 2 10 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL177203 124518 0 None None None Human 6.8 pIC50 = 6.8 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 582 9 2 10 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
10122442 258591 0 None None None Human 6.8 pIC50 = 6.8 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 660 14 2 11 5.6 CCCCNC(=O)OCC#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL368383 258591 0 None None None Human 6.8 pIC50 = 6.8 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 660 14 2 11 5.6 CCCCNC(=O)OCC#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10832511 468422 0 None None None Human 6.8 pIC50 = 6.8 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 362 4 1 5 3.2 CN(C)c1cccc2c(S(=O)(=O)Nc3cnc(Cl)cn3)cccc12 10.1021/jm9604585
CHEMBL6553 468422 0 None None None Human 6.8 pIC50 = 6.8 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 362 4 1 5 3.2 CN(C)c1cccc2c(S(=O)(=O)Nc3cnc(Cl)cn3)cccc12 10.1021/jm9604585
104865 1454 67 None None None Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at ETA receptor (unknown origin) assessed as increase in G protein-mediated vasoconstrictionAntagonist activity at ETA receptor (unknown origin) assessed as increase in G protein-mediated vasoconstriction
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.8b00435
3494 1454 67 None None None Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at ETA receptor (unknown origin) assessed as increase in G protein-mediated vasoconstrictionAntagonist activity at ETA receptor (unknown origin) assessed as increase in G protein-mediated vasoconstriction
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.8b00435
392 1454 67 None None None Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at ETA receptor (unknown origin) assessed as increase in G protein-mediated vasoconstrictionAntagonist activity at ETA receptor (unknown origin) assessed as increase in G protein-mediated vasoconstriction
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.8b00435
CHEMBL957 1454 67 None None None Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at ETA receptor (unknown origin) assessed as increase in G protein-mediated vasoconstrictionAntagonist activity at ETA receptor (unknown origin) assessed as increase in G protein-mediated vasoconstriction
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.8b00435
DB00559 1454 67 None None None Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at ETA receptor (unknown origin) assessed as increase in G protein-mediated vasoconstrictionAntagonist activity at ETA receptor (unknown origin) assessed as increase in G protein-mediated vasoconstriction
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.8b00435
10569313 197516 0 None None None Human 5.8 pIC50 = 5.8 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 342 4 1 5 2.8 Cc1ccc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nn1 10.1021/jm9604585
CHEMBL268387 197516 0 None None None Human 5.8 pIC50 = 5.8 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 342 4 1 5 2.8 Cc1ccc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nn1 10.1021/jm9604585
5018984 468173 0 None None None Human 5.8 pIC50 = 5.8 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 405 4 1 4 3.9 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Br)cn3)cccc12 10.1021/jm9604585
CHEMBL6411 468173 0 None None None Human 5.8 pIC50 = 5.8 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 405 4 1 4 3.9 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Br)cn3)cccc12 10.1021/jm9604585
10690058 468234 0 None None None Human 5.8 pIC50 = 5.8 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 362 4 1 5 3.2 CN(C)c1cccc2c(S(=O)(=O)Nc3ncc(Cl)cn3)cccc12 10.1021/jm9604585
CHEMBL6433 468234 0 None None None Human 5.8 pIC50 = 5.8 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 362 4 1 5 3.2 CN(C)c1cccc2c(S(=O)(=O)Nc3ncc(Cl)cn3)cccc12 10.1021/jm9604585
5017966 468298 0 None None None Human 5.8 pIC50 = 5.8 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 341 4 1 4 3.4 Cc1ccc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nc1 10.1021/jm9604585
CHEMBL6463 468298 0 None None None Human 5.8 pIC50 = 5.8 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 341 4 1 4 3.4 Cc1ccc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nc1 10.1021/jm9604585
23445285 221862 0 None None None Human 6.8 pIC50 = 6.8 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 454 7 1 5 5.6 CCCCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(96)00496-9
CHEMBL329560 221862 0 None None None Human 6.8 pIC50 = 6.8 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 454 7 1 5 5.6 CCCCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(96)00496-9
10250826 199331 0 None None None Rat 4.8 pIC50 = 4.8 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 407 5 1 5 4.7 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1-c1ccccc1 10.1021/jm00008a013
CHEMBL280823 199331 0 None None None Rat 4.8 pIC50 = 4.8 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 407 5 1 5 4.7 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1-c1ccccc1 10.1021/jm00008a013
9980084 202225 0 None None None Rat 4.8 pIC50 = 4.8 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 429 10 1 5 5.7 CCCCN(CCCC)c1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
CHEMBL30245 202225 0 None None None Rat 4.8 pIC50 = 4.8 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 429 10 1 5 5.7 CCCCN(CCCC)c1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
9852624 256615 0 None None None Human 5.8 pIC50 = 5.8 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 656 14 2 11 4.5 CCS(=O)(=O)NCCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL366872 256615 0 None None None Human 5.8 pIC50 = 5.8 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 656 14 2 11 4.5 CCS(=O)(=O)NCCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
10744040 232609 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cccc(C)c2C)cc1 10.1021/jm031041j
CHEMBL332231 232609 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cccc(C)c2C)cc1 10.1021/jm031041j
10815726 25725 0 None None None Human 7.8 pIC50 = 7.8 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 516 8 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(C)c2ccccc2C)cc1 10.1021/jm990171i
CHEMBL1180348 25725 0 None None None Human 7.8 pIC50 = 7.8 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 516 8 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(C)c2ccccc2C)cc1 10.1021/jm990171i
10671649 198828 0 None None None Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 460 5 1 8 3.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL276639 198828 0 None None None Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 460 5 1 8 3.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc3c(c2)OCO3)cc1 10.1021/jm9606507
10299975 219792 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 488 14 1 5 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC(C)CC 10.1021/jm980217s
CHEMBL323791 219792 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 488 14 1 5 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC(C)CC 10.1021/jm980217s
10816152 40222 0 None None None Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 534 9 2 8 3.9 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(OC)cccc2OC)cc1 10.1021/jm990170q
CHEMBL122832 40222 0 None None None Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 534 9 2 8 3.9 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(OC)cccc2OC)cc1 10.1021/jm990170q
10744040 232609 0 None None None Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cccc(C)c2C)cc1 10.1021/jm990170q
CHEMBL332231 232609 0 None None None Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cccc(C)c2C)cc1 10.1021/jm990170q
10552344 121996 0 None None None Rat 7.8 pIC50 = 7.8 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 471 7 1 6 5.1 N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1OC(C(=O)O)c1ccccc1C(F)(F)F 10.1021/jm990378b
CHEMBL170202 121996 0 None None None Rat 7.8 pIC50 = 7.8 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 471 7 1 6 5.1 N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1OC(C(=O)O)c1ccccc1C(F)(F)F 10.1021/jm990378b
44295156 38533 0 None None None Rat 7.8 pIC50 = 7.8 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 520 10 1 9 4.7 COc1ccccc1C(=O)/C(Cc1cc(OC)c(OC)c(OC)c1)=C(\C(=O)O)c1ccc2nsnc2c1 10.1016/s0960-894x(98)00301-1
CHEMBL1205062 38533 0 None None None Rat 7.8 pIC50 = 7.8 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 520 10 1 9 4.7 COc1ccccc1C(=O)/C(Cc1cc(OC)c(OC)c(OC)c1)=C(\C(=O)O)c1ccc2nsnc2c1 10.1016/s0960-894x(98)00301-1
10231591 259248 0 None None None Human 7.8 pIC50 = 7.8 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 569 10 2 11 2.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL368828 259248 0 None None None Human 7.8 pIC50 = 7.8 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 569 10 2 11 2.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
10338502 238229 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2c(S(=O)(=O)Nc3noc(C)c3C)cccc12 10.1021/jm00004a012
CHEMBL345247 238229 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2c(S(=O)(=O)Nc3noc(C)c3C)cccc12 10.1021/jm00004a012
44386370 123182 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 531 10 4 6 4.8 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccc2)nc1C(=O)O 10.1021/jm950592+
CHEMBL175066 123182 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 531 10 4 6 4.8 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccc2)nc1C(=O)O 10.1021/jm950592+
15453177 470356 0 None None None Human 7.8 pIC50 = 7.8 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 392 4 1 4 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL80857 470356 0 None None None Human 7.8 pIC50 = 7.8 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 392 4 1 4 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
10601795 197296 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 10 1 6 4.4 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(CC(C)C)CC(C)C)cc1 10.1021/jm9505369
CHEMBL266354 197296 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 10 1 6 4.4 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(CC(C)C)CC(C)C)cc1 10.1021/jm9505369
44265869 197574 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 466 7 2 6 3.3 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC2CCCC2)cc1 10.1021/jm9505369
CHEMBL268864 197574 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 466 7 2 6 3.3 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC2CCCC2)cc1 10.1021/jm9505369
44278003 199482 0 None None None Human 6.8 pIC50 = 6.8 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 449 8 1 6 5.6 COc1cccc(Sc2c(C(=O)O)n(Cc3ccccc3)c3cc(OC)c(OC)cc23)c1 10.1016/0960-894X(96)00232-6
CHEMBL28188 199482 0 None None None Human 6.8 pIC50 = 6.8 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 449 8 1 6 5.6 COc1cccc(Sc2c(C(=O)O)n(Cc3ccccc3)c3cc(OC)c(OC)cc23)c1 10.1016/0960-894X(96)00232-6
18617302 214134 0 None None None Human 6.8 pIC50 = 6.8 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 334 3 1 4 2.7 Cc1noc(NS(=O)(=O)c2ccccc2F)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL310361 214134 0 None None None Human 6.8 pIC50 = 6.8 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 334 3 1 4 2.7 Cc1noc(NS(=O)(=O)c2ccccc2F)c1Br 10.1016/0960-894X(96)00441-6
15453180 214921 0 None None None Human 6.8 pIC50 = 6.8 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 348 4 1 4 4.1 Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1Cl 10.1016/0960-894X(96)00441-6
CHEMBL311510 214921 0 None None None Human 6.8 pIC50 = 6.8 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 348 4 1 4 4.1 Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1Cl 10.1016/0960-894X(96)00441-6
10951244 468011 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 504 9 1 7 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1cc(OC)ccc1OC)O2 10.1021/jm010382z
CHEMBL62962 468011 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 504 9 1 7 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1cc(OC)ccc1OC)O2 10.1021/jm010382z
11100307 468238 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 354 5 1 5 3.8 CCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm010382z
CHEMBL64340 468238 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 354 5 1 5 3.8 CCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm010382z
44314461 469662 0 None None None Pig 6.8 pIC50 = 6.8 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 605 13 5 4 3.9 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCC1)C(=O)O 10.1021/jm9600914
CHEMBL74837 469662 0 None None None Pig 6.8 pIC50 = 6.8 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 605 13 5 4 3.9 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCC1)C(=O)O 10.1021/jm9600914
10767778 40290 0 None None None Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cc(C)cc(C)c2)cc1 10.1021/jm990170q
CHEMBL123077 40290 0 None None None Human 6.8 pIC50 = 6.8 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cc(C)cc(C)c2)cc1 10.1021/jm990170q
44295114 38780 0 None None None Rat 6.8 pIC50 = 6.8 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 556 11 1 9 5.3 COc1cc(C/C(C(=O)c2ccc(OC(F)F)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
CHEMBL1207717 38780 0 None None None Rat 6.8 pIC50 = 6.8 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 556 11 1 9 5.3 COc1cc(C/C(C(=O)c2ccc(OC(F)F)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
122044 24472 43 None None None Pig 6.8 pIC50 = 6.8 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 473 9 2 8 3.7 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)c1 10.1021/jm0102304
CHEMBL115951 24472 43 None None None Pig 6.8 pIC50 = 6.8 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 473 9 2 8 3.7 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)c1 10.1021/jm0102304
44309814 203056 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 487 8 1 7 6.2 CCCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)n2Cc1cc2nsnc2cc1C 10.1016/s0960-894x(97)10151-2
CHEMBL306863 203056 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 487 8 1 7 6.2 CCCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)n2Cc1cc2nsnc2cc1C 10.1016/s0960-894x(97)10151-2
44327380 221100 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 457 6 1 9 1.4 COc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)n2nc(C)ccc2=O)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL328311 221100 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 457 6 1 9 1.4 COc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)n2nc(C)ccc2=O)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL136634 484663 0 None None None Pig 6.8 pIC50 = 6.8 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 626 9 7 6 1.4 CC(C)C[C@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](C(C)C)NC1=O 10.1021/jm00021a021
CHEMBL337031 486983 0 None None None Pig 6.8 pIC50 = 6.8 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 570 7 7 6 -0.0 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL342840 487086 0 None None None Pig 6.8 pIC50 = 6.8 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 641 10 8 7 -0.4 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10926281 202818 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 354 4 1 5 3.8 CC(C)Oc1ccc2c(c1)C=C(C(=O)O)[C@H](c1ccc3c(c1)OCO3)O2 10.1021/jm031041j
CHEMBL305117 202818 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 354 4 1 5 3.8 CC(C)Oc1ccc2c(c1)C=C(C(=O)O)[C@H](c1ccc3c(c1)OCO3)O2 10.1021/jm031041j
10926281 202818 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 354 4 1 5 3.8 CC(C)Oc1ccc2c(c1)C=C(C(=O)O)[C@H](c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL305117 202818 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 354 4 1 5 3.8 CC(C)Oc1ccc2c(c1)C=C(C(=O)O)[C@H](c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
11026419 468220 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 432 5 1 6 4.5 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3c(OC)cccc32)cc1 10.1021/jm010382z
CHEMBL64266 468220 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 432 5 1 6 4.5 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3c(OC)cccc32)cc1 10.1021/jm010382z
44368819 333531 0 None None None Rat 5.8 pIC50 = 5.8 Binding
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1637 31 19 20 1.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
77282140 333531 0 None None None Rat 5.8 pIC50 = 5.8 Binding
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1637 31 19 20 1.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
CHEMBL438380 333531 0 None None None Rat 5.8 pIC50 = 5.8 Binding
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1637 31 19 20 1.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
44270524 198493 0 None None None Human 5.8 pIC50 = 5.8 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 682 13 1 9 6.9 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1ccccc1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL274243 198493 0 None None None Human 5.8 pIC50 = 5.8 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 682 13 1 9 6.9 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1ccccc1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
44267002 198822 0 None None None Human 4.8 pIC50 = 4.8 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 546 5 1 7 5.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc3c2CCc2ccccc2C3=O)cc1 10.1021/jm9606507
CHEMBL276601 198822 0 None None None Human 4.8 pIC50 = 4.8 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 546 5 1 7 5.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc3c2CCc2ccccc2C3=O)cc1 10.1021/jm9606507
10627398 258581 0 None None None Rat 4.8 pIC50 = 4.8 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 599 11 4 5 5.8 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(Cc2ccccc2)o1 10.1021/jm950591h
CHEMBL368339 258581 0 None None None Rat 4.8 pIC50 = 4.8 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 599 11 4 5 5.8 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(Cc2ccccc2)o1 10.1021/jm950591h
10841170 26390 0 None None None Human 6.8 pIC50 = 6.8 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 592 9 2 6 5.8 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 10.1021/jm990171i
CHEMBL1184090 26390 0 None None None Human 6.8 pIC50 = 6.8 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 592 9 2 6 5.8 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 10.1021/jm990171i
10579647 333162 0 None None None Rat 4.8 pIC50 = 4.8 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 612 11 4 5 5.8 Cc1c(C(=O)O)nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)n1Cc1ccccc1 10.1021/jm950592+
CHEMBL435156 333162 0 None None None Rat 4.8 pIC50 = 4.8 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 612 11 4 5 5.8 Cc1c(C(=O)O)nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)n1Cc1ccccc1 10.1021/jm950592+
10575061 473828 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 439 9 1 6 4.0 CCCCC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9082 473828 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 439 9 1 6 4.0 CCCCC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10646637 473973 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 437 8 1 5 4.9 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C/C=C/CC(C)C)cc1 10.1021/jm9505369
CHEMBL9168 473973 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 437 8 1 5 4.9 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C/C=C/CC(C)C)cc1 10.1021/jm9505369
44368416 97978 0 None None None Pig 4.8 pIC50 = 4.8 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 540 8 2 6 5.6 O=C(O)C(Cc1c[nH]c2ccccc12)N(Cc1cc2c(cc1Cl)OCO2)Cc1cc2c(cc1Cl)OCO2 10.1016/s0960-894x(01)00009-9
CHEMBL152098 97978 0 None None None Pig 4.8 pIC50 = 4.8 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 540 8 2 6 5.6 O=C(O)C(Cc1c[nH]c2ccccc12)N(Cc1cc2c(cc1Cl)OCO2)Cc1cc2c(cc1Cl)OCO2 10.1016/s0960-894x(01)00009-9
10478562 259680 0 None None None Human 5.8 pIC50 = 5.8 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 442 6 1 6 4.5 Cc1ccc(OCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00132-7
CHEMBL369359 259680 0 None None None Human 5.8 pIC50 = 5.8 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 442 6 1 6 4.5 Cc1ccc(OCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00132-7
127026043 274756 0 None None None Human 6.8 pIC50 = 6.8 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 607 11 3 9 3.8 CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3752947 274756 0 None None None Human 6.8 pIC50 = 6.8 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 607 11 3 9 3.8 CCCc1nc2c(C)cc(C(=O)NCCN3CCOCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
44386162 123176 0 None None None Human 6.8 pIC50 = 6.8 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 575 11 1 9 6.2 CC/C=C/COc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL175005 123176 0 None None None Human 6.8 pIC50 = 6.8 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 575 11 1 9 6.2 CC/C=C/COc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10503334 347443 0 None None None Human 6.8 pIC50 = 6.8 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 441 5 2 6 3.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1Br 10.1016/S0960-894X(97)00367-3
CHEMBL45269 347443 0 None None None Human 6.8 pIC50 = 6.8 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 441 5 2 6 3.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1Br 10.1016/S0960-894X(97)00367-3
10503334 347443 0 None None None Human 6.8 pIC50 = 6.8 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 441 5 2 6 3.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1Br 10.1021/jm9608366
CHEMBL45269 347443 0 None None None Human 6.8 pIC50 = 6.8 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 441 5 2 6 3.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1Br 10.1021/jm9608366
10140871 122032 0 None None None Human 6.8 pIC50 = 6.8 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 484 9 2 9 3.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)ncnc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL170342 122032 0 None None None Human 6.8 pIC50 = 6.8 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 484 9 2 9 3.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)ncnc1OCC#CCO 10.1016/s0960-894x(02)01084-3
44383754 122661 0 None None None Human 6.8 pIC50 = 6.8 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 452 5 1 5 5.4 Cc1ccc(/C=C/c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL172987 122661 0 None None None Human 6.8 pIC50 = 6.8 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 452 5 1 5 5.4 Cc1ccc(/C=C/c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL319660 486629 0 None None None Human 7.8 pIC50 = 7.8 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 909 24 9 8 3.8 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
11005243 468400 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 8 1 6 5.6 CCCCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL65337 468400 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 8 1 6 5.6 CCCCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
9801093 122017 0 None None None Rat 7.8 pIC50 = 7.8 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 399 7 1 5 5.1 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccccc1Cl 10.1021/jm990378b
CHEMBL170296 122017 0 None None None Rat 7.8 pIC50 = 7.8 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 399 7 1 5 5.1 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccccc1Cl 10.1021/jm990378b
44295089 38538 0 None None None Rat 7.8 pIC50 = 7.8 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 476 8 1 7 5.4 COc1ccc(C(=O)/C(Cc2ccc(SC)cc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1205088 38538 0 None None None Rat 7.8 pIC50 = 7.8 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 476 8 1 7 5.4 COc1ccc(C(=O)/C(Cc2ccc(SC)cc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
44320192 216705 0 None None None Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 480 6 1 5 5.9 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1Cc1cccc(Cl)c1 10.1016/s0960-894x(00)00513-8
CHEMBL315622 216705 0 None None None Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 480 6 1 5 5.9 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1Cc1cccc(Cl)c1 10.1016/s0960-894x(00)00513-8
10504542 353454 0 None None None Human 7.8 pIC50 = 7.8 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 469 6 2 6 4.4 CCc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9608366
CHEMBL47418 353454 0 None None None Human 7.8 pIC50 = 7.8 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 469 6 2 6 4.4 CCc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9608366
44386536 258605 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 549 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccc2F)nc1C(=O)O 10.1021/jm950592+
CHEMBL368461 258605 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 549 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccc2F)nc1C(=O)O 10.1021/jm950592+
10626245 259053 0 None None None Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 539 10 2 8 5.5 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)OC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL368629 259053 0 None None None Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 539 10 2 8 5.5 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)OC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
44311516 469060 0 None None None Human 7.8 pIC50 = 7.8 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 678 12 2 12 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70339 469060 0 None None None Human 7.8 pIC50 = 7.8 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 678 12 2 12 5.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
137633242 312401 0 None None None Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 569 10 2 10 3.8 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCOC)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4067475 312401 0 None None None Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 569 10 2 10 3.8 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCOC)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
10599230 473927 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 440 8 2 6 2.8 CCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9141 473927 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 440 8 2 6 2.8 CCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
71458718 163103 0 None None None Human 7.8 pIC50 = 7.8 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 615 14 1 12 4.3 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(C)cn1 10.1021/jm3009103
CHEMBL2163700 163103 0 None None None Human 7.8 pIC50 = 7.8 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 615 14 1 12 4.3 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(C)cn1 10.1021/jm3009103
44320783 216354 0 None None None Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 453 6 1 6 5.2 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccnc2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
CHEMBL314357 216354 0 None None None Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 453 6 1 6 5.2 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2cccnc2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
18995986 199779 0 None None None Human 6.8 pIC50 = 6.8 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 537 8 1 10 5.0 COc1ccc(Sc2c(C(=O)O)n(Cc3cc(OC)c4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC 10.1016/0960-894X(96)00232-6
CHEMBL283858 199779 0 None None None Human 6.8 pIC50 = 6.8 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 537 8 1 10 5.0 COc1ccc(Sc2c(C(=O)O)n(Cc3cc(OC)c4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC 10.1016/0960-894X(96)00232-6
18617379 470082 0 None None None Human 6.8 pIC50 = 6.8 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 364 3 1 4 3.5 Cc1noc(NS(=O)(=O)c2cccc(Cl)c2C)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL78669 470082 0 None None None Human 6.8 pIC50 = 6.8 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 364 3 1 4 3.5 Cc1noc(NS(=O)(=O)c2cccc(Cl)c2C)c1Br 10.1016/0960-894X(96)00441-6
10622616 22374 0 None None None Human 6.8 pIC50 = 6.8 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 5 1 6 4.5 CSc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL10911 22374 0 None None None Human 6.8 pIC50 = 6.8 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 5 1 6 4.5 CSc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
10412464 23442 0 None None None Human 6.8 pIC50 = 6.8 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 470 6 1 5 5.4 COc1ccc(CC2=C(c3ccc(Cl)c(Cl)c3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
CHEMBL10996 23442 0 None None None Human 6.8 pIC50 = 6.8 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 470 6 1 5 5.4 COc1ccc(CC2=C(c3ccc(Cl)c(Cl)c3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
11826883 445630 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 476 8 1 6 5.5 COc1ccc(C2=C(C(=O)O)C(c3ccc(OC)c(OC)c3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL59635 445630 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 476 8 1 6 5.5 COc1ccc(C2=C(C(=O)O)C(c3ccc(OC)c(OC)c3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
11017198 218598 0 None None None Pig 6.8 pIC50 = 6.8 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 563 12 1 8 6.0 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOCc2ccccc2)c1 10.1021/jm0102304
CHEMBL321226 218598 0 None None None Pig 6.8 pIC50 = 6.8 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 563 12 1 8 6.0 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOCc2ccccc2)c1 10.1021/jm0102304
10765567 220860 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 440 9 1 5 3.4 CCCN(C)C(=O)CN1C[C@H](c2cccc(OC)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL326951 220860 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 440 9 1 5 3.4 CCCN(C)C(=O)CN1C[C@H](c2cccc(OC)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
9870117 387894 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 488 10 1 7 5.5 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC=O)c1 10.1016/j.bmcl.2016.06.014
CHEMBL54057 387894 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 488 10 1 7 5.5 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC=O)c1 10.1016/j.bmcl.2016.06.014
9870117 387894 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 488 10 1 7 5.5 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC=O)c1 10.1016/s0960-894x(00)00366-8
CHEMBL54057 387894 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 488 10 1 7 5.5 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC=O)c1 10.1016/s0960-894x(00)00366-8
44277367 216497 0 None None None Rat 5.8 pIC50 = 5.8 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 392 4 2 5 3.3 O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1cccc(O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144606 216497 0 None None None Rat 5.8 pIC50 = 5.8 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 392 4 2 5 3.3 O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1cccc(O)c1 10.1016/s0960-894x(00)00232-8
44387128 333257 0 None None None Human 5.8 pIC50 = 5.8 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 558 12 2 10 3.8 CNCC(=O)OCCOc1nc(C)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/S0960-894X(97)00400-9
CHEMBL435895 333257 0 None None None Human 5.8 pIC50 = 5.8 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 558 12 2 10 3.8 CNCC(=O)OCCOc1nc(C)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/S0960-894X(97)00400-9
CHEMBL422464 488435 0 None None None Pig 5.8 pIC50 = 5.8 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 596 7 6 6 0.7 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCO)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
5310990 327639 15 None None None Rat 6.8 pIC50 = 6.8 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL428504 327639 15 None None None Rat 6.8 pIC50 = 6.8 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
23445506 222038 0 None None None Human 5.8 pIC50 = 5.8 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 428 5 1 6 4.3 COc1ccccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL330003 222038 0 None None None Human 5.8 pIC50 = 5.8 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 428 5 1 6 4.3 COc1ccccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(96)00496-9
10452145 198491 0 None None None Rat 4.8 pIC50 = 4.8 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 376 5 1 7 2.9 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1[N+](=O)[O-] 10.1021/jm00008a013
CHEMBL27420 198491 0 None None None Rat 4.8 pIC50 = 4.8 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 376 5 1 7 2.9 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1[N+](=O)[O-] 10.1021/jm00008a013
10813007 232369 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 440 9 1 5 3.4 CCCN(C)C(=O)CN1C[C@H](c2ccc(OC)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL331577 232369 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 440 9 1 5 3.4 CCCN(C)C(=O)CN1C[C@H](c2ccc(OC)cc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
44384852 123011 0 None None None Human 6.8 pIC50 = 6.8 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 544 9 1 8 5.5 C#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL174094 123011 0 None None None Human 6.8 pIC50 = 6.8 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 544 9 1 8 5.5 C#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10362674 198085 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 385 4 1 5 4.2 Cc1noc(NS(=O)(=O)c2cccc3c(N4CCCCC4)cccc23)c1C 10.1021/jm00008a013
CHEMBL27178 198085 0 None None None Rat 5.8 pIC50 = 5.8 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 385 4 1 5 4.2 Cc1noc(NS(=O)(=O)c2cccc3c(N4CCCCC4)cccc23)c1C 10.1021/jm00008a013
10742446 473941 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 456 9 2 7 2.0 COCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9147 473941 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 456 9 2 7 2.0 COCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10650638 23489 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 566 13 1 6 4.8 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(F)c(F)c1 10.1021/jm970101g
CHEMBL110305 23489 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 566 13 1 6 4.8 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(F)c(F)c1 10.1021/jm970101g
10647898 197654 0 None None None Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 466 5 1 6 5.0 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc3ccccc23)cc1 10.1021/jm9606507
CHEMBL269409 197654 0 None None None Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 466 5 1 6 5.0 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc3ccccc23)cc1 10.1021/jm9606507
10993781 462847 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 434 7 1 7 5.0 CCCCC1=C(c2nnn[nH]2)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL60440 462847 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 434 7 1 7 5.0 CCCCC1=C(c2nnn[nH]2)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
10896412 467884 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 504 9 1 7 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)cc1OC)O2 10.1021/jm010382z
CHEMBL62277 467884 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 504 9 1 7 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)cc1OC)O2 10.1021/jm010382z
15410997 19048 0 None None None Human 7.8 pIC50 = 7.8 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 563 8 1 7 6.3 COc1ccc(C2(OC(=O)N[C@@H](C)c3ccccc3)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1016/S0960-894X(97)00002-4
CHEMBL103501 19048 0 None None None Human 7.8 pIC50 = 7.8 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 563 8 1 7 6.3 COc1ccc(C2(OC(=O)N[C@@H](C)c3ccccc3)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1016/S0960-894X(97)00002-4
CHEMBL2370534 485589 0 None None None Human 7.8 pIC50 = 7.8 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 3576 117 49 46 -11.9 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCCNC(=O)CC[C@@H](NC(=O)[C@H](CCCC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](N)Cc2ccccc2)C(C)C)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(N)=O)[C@@H](C)CC)[C@@H](C)CC 10.1021/jm990170q
151174 467527 37 None None None Human 7.8 pIC50 = 7.8 Binding
Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsDisplacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cells
ChEMBL 605 12 3 13 3.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccnc(-c3nn[nH]n3)c2)nc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL61780 467527 37 None None None Human 7.8 pIC50 = 7.8 Binding
Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsDisplacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cells
ChEMBL 605 12 3 13 3.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccnc(-c3nn[nH]n3)c2)nc1OCCO 10.1016/j.bmcl.2016.06.014
DB06558 467527 37 None None None Human 7.8 pIC50 = 7.8 Binding
Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsDisplacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cells
ChEMBL 605 12 3 13 3.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccnc(-c3nn[nH]n3)c2)nc1OCCO 10.1016/j.bmcl.2016.06.014
76319370 176302 0 None None None Human 7.8 pIC50 = 7.8 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 564 8 1 9 4.0 CCOC(=O)c1ccc2c(C(C(=O)NS(=O)(=O)c3ccc(C)cc3OC)c3ccc4c(c3)OCO4)cn(C)c2c1 10.1007/s00044-004-0021-y
CHEMBL2261602 176302 0 None None None Human 7.8 pIC50 = 7.8 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 564 8 1 9 4.0 CCOC(=O)c1ccc2c(C(C(=O)NS(=O)(=O)c3ccc(C)cc3OC)c3ccc4c(c3)OCO4)cn(C)c2c1 10.1007/s00044-004-0021-y
10050696 197105 0 None None None Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 476 7 1 6 5.3 COc1cccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c1 10.1016/s0960-894x(00)00513-8
CHEMBL26474 197105 0 None None None Rat 7.8 pIC50 = 7.8 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 476 7 1 6 5.3 COc1cccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c1 10.1016/s0960-894x(00)00513-8
10050696 197105 0 None None None Rat 7.8 pIC50 = 7.8 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 476 7 1 6 5.3 COc1cccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL26474 197105 0 None None None Rat 7.8 pIC50 = 7.8 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 476 7 1 6 5.3 COc1cccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c1 10.1016/s0960-894x(00)00232-8
10138169 199569 0 None None None Human 7.8 pIC50 = 7.8 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 440 6 1 8 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1Cl 10.1021/jm9700068
CHEMBL282470 199569 0 None None None Human 7.8 pIC50 = 7.8 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 440 6 1 8 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1Cl 10.1021/jm9700068
10211772 119322 0 None None None Human 7.8 pIC50 = 7.8 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 660 11 2 12 4.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
CHEMBL163638 119322 0 None None None Human 7.8 pIC50 = 7.8 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 660 11 2 12 4.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
10165809 259681 0 None None None Human 7.8 pIC50 = 7.8 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 541 9 2 11 2.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL369362 259681 0 None None None Human 7.8 pIC50 = 7.8 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 541 9 2 11 2.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL61900 489345 0 None None None Pig 7.8 pIC50 = 7.8 Binding
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL 893 21 9 8 2.9 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
44327412 474466 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 497 5 1 8 3.0 Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL94929 474466 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 497 5 1 8 3.0 Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
44385621 256136 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 550 10 5 5 4.6 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2C)nc1C(=O)O 10.1021/jm950592+
CHEMBL366544 256136 0 None None None Rat 7.8 pIC50 = 7.8 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 550 10 5 5 4.6 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2C)nc1C(=O)O 10.1021/jm950592+
44356917 238015 0 None None None Pig 7.8 pIC50 = 7.8 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 638 8 5 8 0.3 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2cn(C=O)c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL343516 238015 0 None None None Pig 7.8 pIC50 = 7.8 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 638 8 5 8 0.3 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2cn(C=O)c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL2370825 485620 0 None None None Pig 7.8 pIC50 = 7.8 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 626 7 7 7 -0.2 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2C[C@@H](O)CN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
11091217 201204 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 9 1 6 5.0 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2cc(OCCC)ccc21 10.1021/jm010382z
CHEMBL294787 201204 0 None None None Rat 6.8 pIC50 = 6.8 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 9 1 6 5.0 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2cc(OCCC)ccc21 10.1021/jm010382z
44283421 200329 0 None None None Pig 6.8 pIC50 = 6.8 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 597 14 5 4 4.9 CCCC[C@H](NC(=O)[C@@H](Cc1c(CC)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
44314722 200329 0 None None None Pig 6.8 pIC50 = 6.8 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 597 14 5 4 4.9 CCCC[C@H](NC(=O)[C@@H](Cc1c(CC)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL287888 200329 0 None None None Pig 6.8 pIC50 = 6.8 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 597 14 5 4 4.9 CCCC[C@H](NC(=O)[C@@H](Cc1c(CC)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL405724 200329 0 None None None Pig 6.8 pIC50 = 6.8 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 597 14 5 4 4.9 CCCC[C@H](NC(=O)[C@@H](Cc1c(CC)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL293216 486391 0 None None None Pig 6.8 pIC50 = 6.8 Binding
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL 906 22 9 8 2.6 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
44283421 200329 0 None None None Pig 6.8 pIC50 = 6.8 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 597 14 5 4 4.9 CCCC[C@H](NC(=O)[C@@H](Cc1c(CC)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
44314722 200329 0 None None None Pig 6.8 pIC50 = 6.8 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 597 14 5 4 4.9 CCCC[C@H](NC(=O)[C@@H](Cc1c(CC)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
CHEMBL287888 200329 0 None None None Pig 6.8 pIC50 = 6.8 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 597 14 5 4 4.9 CCCC[C@H](NC(=O)[C@@H](Cc1c(CC)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
CHEMBL405724 200329 0 None None None Pig 6.8 pIC50 = 6.8 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 597 14 5 4 4.9 CCCC[C@H](NC(=O)[C@@H](Cc1c(CC)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
44383742 333183 0 None None None Human 6.8 pIC50 = 6.8 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 452 5 1 5 5.4 Cc1ccc(/C=C/c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL435346 333183 0 None None None Human 6.8 pIC50 = 6.8 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 452 5 1 5 5.4 Cc1ccc(/C=C/c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL137361 484666 0 None None None Pig 6.8 pIC50 = 6.8 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 628 9 8 7 -0.2 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL313382 486530 0 None None None Human 5.8 pIC50 = 5.8 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 886 24 10 8 3.1 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL86814 489396 0 None None None Human 5.8 pIC50 = 5.8 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 847 24 9 8 2.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
44368819 333531 0 None None None Human 5.8 pIC50 = 5.8 Binding
Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)
ChEMBL 1637 31 19 20 1.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
77282140 333531 0 None None None Human 5.8 pIC50 = 5.8 Binding
Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)
ChEMBL 1637 31 19 20 1.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
CHEMBL438380 333531 0 None None None Human 5.8 pIC50 = 5.8 Binding
Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)
ChEMBL 1637 31 19 20 1.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
44316973 470435 1 None None None Human 5.8 pIC50 = 5.8 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1noc(NS(=O)(=O)c2cccc(Br)c2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL81593 470435 1 None None None Human 5.8 pIC50 = 5.8 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1noc(NS(=O)(=O)c2cccc(Br)c2)c1C 10.1016/0960-894X(96)00441-6
127035067 273837 0 None None None Human 5.8 pIC50 = 5.8 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 683 12 2 9 5.4 CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735236 273837 0 None None None Human 5.8 pIC50 = 5.8 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 683 12 2 9 5.4 CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
44368824 197153 0 None None None Rat 5.8 pIC50 = 5.8 Binding
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1595 31 19 20 0.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
77282142 197153 0 None None None Rat 5.8 pIC50 = 5.8 Binding
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1595 31 19 20 0.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
CHEMBL265164 197153 0 None None None Rat 5.8 pIC50 = 5.8 Binding
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1595 31 19 20 0.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
CHEMBL436899 488642 0 None None None Rat 5.8 pIC50 = 5.8 Binding
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1583 32 20 21 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
44277034 216502 0 None None None Rat 5.8 pIC50 = 5.8 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 406 5 1 5 3.6 COc1ccccc1Cn1[nH]c(C(F)(F)F)c(Cc2ccc3c(c2)OCO3)c1=O 10.1016/s0960-894x(00)00232-8
CHEMBL3144729 216502 0 None None None Rat 5.8 pIC50 = 5.8 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 406 5 1 5 3.6 COc1ccccc1Cn1[nH]c(C(F)(F)F)c(Cc2ccc3c(c2)OCO3)c1=O 10.1016/s0960-894x(00)00232-8
CHEMBL1791279 484828 0 None None None Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cellsInhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cells
ChEMBL 847 24 9 8 2.6 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)[C@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00152-J
171348836 386247 0 None None None Human 4.8 pIC50 = 4.8 Binding
Binding affinity to recombinant human ETABinding affinity to recombinant human ETA
ChEMBL 439 7 2 6 3.3 O=S(=O)(Nc1ncnc(OCCO)c1-c1ccccc1)c1ccc(C(F)(F)F)cc1 10.1021/acs.jmedchem.0c01093
CHEMBL5272983 386247 0 None None None Human 4.8 pIC50 = 4.8 Binding
Binding affinity to recombinant human ETABinding affinity to recombinant human ETA
ChEMBL 439 7 2 6 3.3 O=S(=O)(Nc1ncnc(OCCO)c1-c1ccccc1)c1ccc(C(F)(F)F)cc1 10.1021/acs.jmedchem.0c01093
19735343 350024 0 None None None Human 4.8 pIC50 = 4.8 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 473 7 2 6 4.0 O=S(=O)(Nc1ncnc(OCCO)c1-c1ccc(Cl)cc1)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4590568 350024 0 None None None Human 4.8 pIC50 = 4.8 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 473 7 2 6 4.0 O=S(=O)(Nc1ncnc(OCCO)c1-c1ccc(Cl)cc1)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2016.06.014
23445516 216292 0 None None None Human 6.7 pIC50 = 6.7 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 468 7 1 5 5.9 Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(CCC(C)C)cc2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL314307 216292 0 None None None Human 6.7 pIC50 = 6.7 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 468 7 1 5 5.9 Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(CCC(C)C)cc2)c1Br 10.1016/S0960-894X(96)00496-9
23445354 473587 0 None None None Human 6.7 pIC50 = 6.7 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 426 5 1 5 4.8 CCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(96)00496-9
CHEMBL89203 473587 0 None None None Human 6.7 pIC50 = 6.7 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 426 5 1 5 4.8 CCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(96)00496-9
CHEMBL273391 486314 0 None None None Human 4.7 pIC50 = 4.7 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 847 24 9 8 2.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL273391 486314 0 None None None Human 4.7 pIC50 = 4.7 Binding
Displacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cellsDisplacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cells
ChEMBL 847 24 9 8 2.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81215-4
18184206 123100 0 None None None Human 6.7 pIC50 = 6.7 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 600 13 2 11 3.2 CCS(=O)(=O)NCCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL174413 123100 0 None None None Human 6.7 pIC50 = 6.7 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 600 13 2 11 3.2 CCS(=O)(=O)NCCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
44385792 123119 0 None None None Human 5.7 pIC50 = 5.7 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 617 13 2 11 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(C2CC2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL174547 123119 0 None None None Human 5.7 pIC50 = 5.7 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 617 13 2 11 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(C2CC2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
44384966 122773 0 None None None Human 6.7 pIC50 = 6.7 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 545 9 1 9 4.8 C#CCOc1nc(-c2cnccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL173465 122773 0 None None None Human 6.7 pIC50 = 6.7 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 545 9 1 9 4.8 C#CCOc1nc(-c2cnccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
71460537 163126 0 None None None Human 6.7 pIC50 = 6.7 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 660 12 1 13 2.7 COc1ccccc1Oc1c(NS(=O)(=O)N2CCOCC2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163722 163126 0 None None None Human 6.7 pIC50 = 6.7 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 660 12 1 13 2.7 COc1ccccc1Oc1c(NS(=O)(=O)N2CCOCC2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
10765057 328163 0 None None None Human 7.7 pIC50 = 7.7 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 430 4 1 7 3.5 O=C1OC(O)(c2ccc3c(c2)OCO3)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
CHEMBL417978 328163 0 None None None Human 7.7 pIC50 = 7.7 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 430 4 1 7 3.5 O=C1OC(O)(c2ccc3c(c2)OCO3)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
CHEMBL2304012 485314 0 None None None Pig 7.7 pIC50 = 7.7 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 700 6 6 6 1.7 CC(C)[C@H]1NC(=O)[C@H](C2CCCC2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Br)[nH]c3ccccc23)NC1=O 10.1021/jm9600914
44458399 199226 0 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 520 7 2 7 4.2 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(CO)ccc23)cc1 10.1016/s0960-894x(01)00660-6
CHEMBL279947 199226 0 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 520 7 2 7 4.2 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(CO)ccc23)cc1 10.1016/s0960-894x(01)00660-6
73669992 236470 0 None None None Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 387 9 1 4 5.4 N#CCCC(Oc1cc(OCc2ccccc2)ccc1C(=O)O)c1ccccc1 10.1016/j.bmc.2015.01.003
CHEMBL3400998 236470 0 None None None Rat 7.7 pIC50 = 7.7 Binding
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 387 9 1 4 5.4 N#CCCC(Oc1cc(OCc2ccccc2)ccc1C(=O)O)c1ccccc1 10.1016/j.bmc.2015.01.003
10814776 199673 0 None None None Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 485 5 2 8 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2)OCO3)c1Br 10.1021/jm9608366
10814776 199673 0 None None None Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 485 5 2 8 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
CHEMBL283136 199673 0 None None None Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 485 5 2 8 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2)OCO3)c1Br 10.1021/jm9608366
CHEMBL283136 199673 0 None None None Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 485 5 2 8 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
44387111 331025 0 None None None Rat 7.7 pIC50 = 7.7 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 548 10 5 5 4.2 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O 10.1021/jm950592+
CHEMBL426413 331025 0 None None None Rat 7.7 pIC50 = 7.7 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 548 10 5 5 4.2 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O 10.1021/jm950592+
9830773 258136 0 None None None Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 636 14 2 12 2.8 CCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL367958 258136 0 None None None Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 636 14 2 12 2.8 CCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
10814776 199673 0 None None None Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 485 5 2 8 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2)OCO3)c1Br 10.1021/jm000349x
CHEMBL283136 199673 0 None None None Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 485 5 2 8 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2)OCO3)c1Br 10.1021/jm000349x
CHEMBL341994 487053 0 None None None Pig 7.7 pIC50 = 7.7 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 646 7 6 6 1.5 CC(C)C[C@H]1NC(=O)[C@H](C2=CCC=CC2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10410546 23716 0 None None None Human 6.7 pIC50 = 6.7 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 7 1 6 4.1 COc1ccc(CC2=C(c3ccc(OC)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
CHEMBL11162 23716 0 None None None Human 6.7 pIC50 = 6.7 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 7 1 6 4.1 COc1ccc(CC2=C(c3ccc(OC)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
44279481 221868 0 None None None Pig 6.7 pIC50 = 6.7 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 555 11 5 4 4.0 CC(C)C[C@H](NC(=O)N1C(C)(C)CCCC1(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL32959 221868 0 None None None Pig 6.7 pIC50 = 6.7 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 555 11 5 4 4.0 CC(C)C[C@H](NC(=O)N1C(C)(C)CCCC1(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
10674095 232557 0 None None None Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 544 9 1 6 5.1 CCc1cccc(CC)c1N(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
CHEMBL332093 232557 0 None None None Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 544 9 1 6 5.1 CCc1cccc(CC)c1N(C)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
CHEMBL135906 484657 0 None None None Pig 6.7 pIC50 = 6.7 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 600 8 8 7 -0.7 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44316983 214504 0 None None None Human 5.7 pIC50 = 5.7 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 312 5 1 6 2.1 COc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1OC 10.1016/0960-894X(96)00441-6
CHEMBL310944 214504 0 None None None Human 5.7 pIC50 = 5.7 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 312 5 1 6 2.1 COc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1OC 10.1016/0960-894X(96)00441-6
44371670 278868 0 None None None Human 5.7 pIC50 = 5.7 Binding
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptorBinding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor
ChEMBL 1082 23 11 10 3.7 CC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C1c2ccccc2CCc2ccccc21 10.1016/0960-894X(95)00084-7
CHEMBL385405 278868 0 None None None Human 5.7 pIC50 = 5.7 Binding
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptorBinding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor
ChEMBL 1082 23 11 10 3.7 CC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C1c2ccccc2CCc2ccccc21 10.1016/0960-894X(95)00084-7
44277035 216511 0 None None None Rat 5.7 pIC50 = 5.7 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 410 4 1 4 4.2 O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1cccc(Cl)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144806 216511 0 None None None Rat 5.7 pIC50 = 5.7 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 410 4 1 4 4.2 O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1cccc(Cl)c1 10.1016/s0960-894x(00)00232-8
10554385 122987 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 537 10 4 5 4.8 CCc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
CHEMBL174000 122987 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 537 10 4 5 4.8 CCc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
10721963 123326 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 580 11 5 6 3.7 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)NCC(=O)O 10.1021/jm950592+
CHEMBL175924 123326 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 580 11 5 6 3.7 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)NCC(=O)O 10.1021/jm950592+
44386620 335156 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 549 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccc(F)cc2)nc1C(=O)O 10.1021/jm950592+
CHEMBL445076 335156 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 549 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccc(F)cc2)nc1C(=O)O 10.1021/jm950592+
44311218 203177 0 None None None Human 5.7 pIC50 = 5.7 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 607 11 2 10 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)Nc1ccncc1 10.1016/S0960-894X(97)00400-9
CHEMBL307803 203177 0 None None None Human 5.7 pIC50 = 5.7 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 607 11 2 10 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)Nc1ccncc1 10.1016/S0960-894X(97)00400-9
18617344 470134 0 None None None Human 4.7 pIC50 = 4.7 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 361 4 1 6 2.5 Cc1noc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL79080 470134 0 None None None Human 4.7 pIC50 = 4.7 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 361 4 1 6 2.5 Cc1noc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)c1Br 10.1016/0960-894X(96)00441-6
15342056 473942 0 None None None Human 5.7 pIC50 = 5.7 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 322 3 1 5 2.6 Cc1noc(NS(=O)(=O)c2cccs2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL91470 473942 0 None None None Human 5.7 pIC50 = 5.7 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 322 3 1 5 2.6 Cc1noc(NS(=O)(=O)c2cccs2)c1Br 10.1016/S0960-894X(96)00496-9
10503976 25518 0 None None None Human 5.7 pIC50 = 5.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 1 6 3.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)N(C)c2ccccc2)c1Br 10.1021/jm9608366
CHEMBL1178874 25518 0 None None None Human 5.7 pIC50 = 5.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 1 6 3.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)N(C)c2ccccc2)c1Br 10.1021/jm9608366
10211543 259270 0 None None None Human 6.7 pIC50 = 6.7 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 640 13 2 12 3.5 CCCCNC(=O)OCC#CCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL368989 259270 0 None None None Human 6.7 pIC50 = 6.7 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 640 13 2 12 3.5 CCCCNC(=O)OCC#CCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10341117 328196 1 None None None Rat 5.7 pIC50 = 5.7 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 403 8 3 6 3.5 Cc1noc(NS(=O)(=O)c2cccc3c(NCCCC(=O)O)cccc23)c1C 10.1021/jm00008a013
CHEMBL418202 328196 1 None None None Rat 5.7 pIC50 = 5.7 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 403 8 3 6 3.5 Cc1noc(NS(=O)(=O)c2cccc3c(NCCCC(=O)O)cccc23)c1C 10.1021/jm00008a013
10554085 201417 0 None None None Human 4.7 pIC50 = 4.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 524 6 1 9 3.2 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)N2CCN(Cc3ccc4c(c3)OCO4)CC2)c1Cl 10.1021/jm9700068
CHEMBL296427 201417 0 None None None Human 4.7 pIC50 = 4.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 524 6 1 9 3.2 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)N2CCN(Cc3ccc4c(c3)OCO4)CC2)c1Cl 10.1021/jm9700068
10817024 26399 0 None None None Human 6.7 pIC50 = 6.7 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 578 10 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NCC(c2ccccc2)c2ccccc2)cc1 10.1021/jm990171i
CHEMBL1184112 26399 0 None None None Human 6.7 pIC50 = 6.7 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 578 10 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NCC(c2ccccc2)c2ccccc2)cc1 10.1021/jm990171i
44279140 220157 0 None None None Human 6.7 pIC50 = 6.7 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 588 12 2 6 5.8 CCCCCNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
CHEMBL32574 220157 0 None None None Human 6.7 pIC50 = 6.7 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 588 12 2 6 5.8 CCCCCNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
11793037 468698 1 None None None Human 6.7 pIC50 = 6.7 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 362 4 1 5 3.2 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)nn3)cccc12 10.1021/jm9604585
CHEMBL6761 468698 1 None None None Human 6.7 pIC50 = 6.7 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 362 4 1 5 3.2 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)nn3)cccc12 10.1021/jm9604585
9885296 197293 0 None None None Human 5.7 pIC50 = 5.7 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 361 4 1 4 3.8 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)cn3)cccc12 10.1021/jm9604585
CHEMBL266315 197293 0 None None None Human 5.7 pIC50 = 5.7 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 361 4 1 4 3.8 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)cn3)cccc12 10.1021/jm9604585
10786783 468449 0 None None None Human 5.7 pIC50 = 5.7 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 393 4 1 5 3.2 COc1nc(Br)cnc1NS(=O)(=O)c1cccc2ccccc12 10.1021/jm9604585
CHEMBL6576 468449 0 None None None Human 5.7 pIC50 = 5.7 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 393 4 1 5 3.2 COc1nc(Br)cnc1NS(=O)(=O)c1cccc2ccccc12 10.1021/jm9604585
10740137 468526 0 None None None Human 5.7 pIC50 = 5.7 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 406 4 1 5 3.3 CN(C)c1cccc2c(S(=O)(=O)Nc3ncc(Br)cn3)cccc12 10.1021/jm9604585
CHEMBL6630 468526 0 None None None Human 5.7 pIC50 = 5.7 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 406 4 1 5 3.3 CN(C)c1cccc2c(S(=O)(=O)Nc3ncc(Br)cn3)cccc12 10.1021/jm9604585
10230836 23219 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 546 13 1 7 4.1 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm970101g
CHEMBL109765 23219 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 546 13 1 7 4.1 CCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm970101g
10209319 23674 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 546 13 1 7 4.1 CCCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCC 10.1021/jm970101g
CHEMBL111355 23674 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 546 13 1 7 4.1 CCCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCC 10.1021/jm970101g
10507211 219906 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 566 13 1 7 3.9 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCCCl 10.1021/jm970101g
CHEMBL324214 219906 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 566 13 1 7 3.9 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCCCl 10.1021/jm970101g
9807691 200240 0 None None None Human 8.7 pIC50 = 8.7 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 553 10 1 10 5.3 COc1cc2c(Sc3cc(OC)c(OC)c(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00232-6
CHEMBL287169 200240 0 None None None Human 8.7 pIC50 = 8.7 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 553 10 1 10 5.3 COc1cc2c(Sc3cc(OC)c(OC)c(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00232-6
11732669 468162 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 9 1 6 5.0 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OCCC)cc21 10.1021/jm010382z
CHEMBL64039 468162 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 9 1 6 5.0 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OCCC)cc21 10.1021/jm010382z
10602267 22900 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 529 13 1 6 3.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCCC1=O 10.1021/jm980217s
CHEMBL109478 22900 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 529 13 1 6 3.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1CCCCC1=O 10.1021/jm980217s
44332842 219281 0 None None None Human 8.7 pIC50 = 8.7 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 703 11 1 10 7.5 COc1ccc(C2(OC(=O)N[C@@H](C)c3cccc4ccccc34)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/S0960-894X(97)00002-4
CHEMBL322920 219281 0 None None None Human 8.7 pIC50 = 8.7 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 703 11 1 10 7.5 COc1ccc(C2(OC(=O)N[C@@H](C)c3cccc4ccccc34)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/S0960-894X(97)00002-4
44315009 203254 0 None None None Pig 8.7 pIC50 = 8.7 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 665 13 5 5 4.7 CSCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL308403 203254 0 None None None Pig 8.7 pIC50 = 8.7 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 665 13 5 5 4.7 CSCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
10791702 391925 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 506 12 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2cccc3occc23)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL558148 391925 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 506 12 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2cccc3occc23)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
9895957 24953 18 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1039/C4MD00499J
CHEMBL11706 24953 18 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1039/C4MD00499J
21041288 347998 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 526 10 2 9 2.8 CNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4540866 347998 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 526 10 2 9 2.8 CNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
155563100 349288 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 619 13 2 10 4.6 COc1cnc(OCCOc2nc(-c3ccncc3)nc(NS(=O)(=O)NCc3ccccc3)c2-c2ccc(Cl)cc2)nc1 10.1016/j.bmcl.2016.06.014
CHEMBL4572734 349288 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 619 13 2 10 4.6 COc1cnc(OCCOc2nc(-c3ccncc3)nc(NS(=O)(=O)NCc3ccccc3)c2-c2ccc(Cl)cc2)nc1 10.1016/j.bmcl.2016.06.014
9829478 349334 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 567 10 1 8 4.9 Cc1ccc(-c2c(NS(=O)(=O)/C=C/c3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4573806 349334 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 567 10 1 8 4.9 Cc1ccc(-c2c(NS(=O)(=O)/C=C/c3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1016/j.bmcl.2016.06.014
10146377 123181 0 None None None Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 662 11 2 14 3.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
CHEMBL175058 123181 0 None None None Human 8.7 pIC50 = 8.7 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 662 11 2 14 3.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
10816682 202233 0 None None None Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 559 10 1 9 3.9 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCCN3CCOCC3)c2)cc1 10.1021/jm980504w
CHEMBL302493 202233 0 None None None Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 559 10 1 9 3.9 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCCN3CCOCC3)c2)cc1 10.1021/jm980504w
10579885 202767 0 None None None Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 632 12 1 11 3.9 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCN3CCN(C)CC3)c2)cc1 10.1021/jm980504w
CHEMBL304802 202767 0 None None None Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 632 12 1 11 3.9 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCCN3CCN(C)CC3)c2)cc1 10.1021/jm980504w
10814440 198438 0 None None None Human 8.7 pIC50 = 8.7 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 476 7 1 8 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)ccc2OC)cc1 10.1021/jm9606507
CHEMBL273723 198438 0 None None None Human 8.7 pIC50 = 8.7 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 476 7 1 8 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)ccc2OC)cc1 10.1021/jm9606507
71462247 163127 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 680 14 2 12 4.2 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2cnccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163723 163127 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 680 14 2 12 4.2 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2cnccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
23548253 163105 0 None None None Human 8.7 pIC50 = 8.7 Binding
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 679 14 1 12 4.7 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1016/j.bmcl.2016.06.014
CHEMBL2163702 163105 0 None None None Human 8.7 pIC50 = 8.7 Binding
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 679 14 1 12 4.7 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1016/j.bmcl.2016.06.014
11014820 467978 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 398 6 1 6 4.2 CCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL62780 467978 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 398 6 1 6 4.2 CCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
10602183 23544 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 525 13 1 7 3.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1ccccc1=O 10.1021/jm980217s
CHEMBL110695 23544 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 525 13 1 7 3.6 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCn1ccccc1=O 10.1021/jm980217s
10625152 219993 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 498 13 1 6 4.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccoc1 10.1021/jm980217s
CHEMBL324685 219993 0 None None None Rat 8.7 pIC50 = 8.7 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 498 13 1 6 4.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccoc1 10.1021/jm980217s
90766557 335079 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 528 10 2 8 3.1 CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4449731 335079 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 528 10 2 8 3.1 CCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
22467266 176293 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 522 7 2 8 3.4 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 10.1007/s00044-004-0021-y
76312118 176293 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 522 7 2 8 3.4 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261360 176293 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 522 7 2 8 3.4 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261361 176293 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 522 7 2 8 3.4 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 10.1007/s00044-004-0021-y
9916121 163096 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 571 10 1 8 4.1 CCCS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
CHEMBL2163693 163096 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 571 10 1 8 4.1 CCCS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
23548253 163105 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 679 14 1 12 4.7 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163702 163105 0 None None None Human 8.7 pIC50 = 8.7 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 679 14 1 12 4.7 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
44334130 18856 0 None None None Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 458 5 1 6 4.4 COc1ccc([C@@H]2c3nc(N4CCCC4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
CHEMBL102173 18856 0 None None None Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 458 5 1 6 4.4 COc1ccc([C@@H]2c3nc(N4CCCC4)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
9808602 218785 0 None None None Rat 8.6 pIC50 = 8.6 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 590 15 1 8 4.5 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(OC)c1 10.1021/jm970101g
CHEMBL321673 218785 0 None None None Rat 8.6 pIC50 = 8.6 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 590 15 1 8 4.5 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(OC)c1 10.1021/jm970101g
11826062 468042 0 None None None Rat 8.6 pIC50 = 8.6 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 8 2 6 4.3 CC(C)Oc1ccc2c(c1)C(CCCCO)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL63113 468042 0 None None None Rat 8.6 pIC50 = 8.6 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 8 2 6 4.3 CC(C)Oc1ccc2c(c1)C(CCCCO)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
10696876 219872 0 None None None Rat 8.6 pIC50 = 8.6 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 504 13 1 7 3.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1OCCO1 10.1021/jm980217s
CHEMBL323989 219872 0 None None None Rat 8.6 pIC50 = 8.6 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 504 13 1 7 3.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1OCCO1 10.1021/jm980217s
22467235 196863 0 None None None Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 533 7 2 7 3.8 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 10.1016/s0960-894x(01)00660-6
CHEMBL262784 196863 0 None None None Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 533 7 2 7 3.8 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 10.1016/s0960-894x(01)00660-6
22467235 196863 0 None None None Human 8.6 pIC50 = 8.6 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 533 7 2 7 3.8 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 10.1007/s00044-004-0021-y
CHEMBL262784 196863 0 None None None Human 8.6 pIC50 = 8.6 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 533 7 2 7 3.8 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 10.1007/s00044-004-0021-y
71462321 163434 0 None None None Human 8.6 pIC50 = 8.6 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 584 12 2 8 4.2 CCc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm3009103
CHEMBL2165335 163434 0 None None None Human 8.6 pIC50 = 8.6 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 584 12 2 8 4.2 CCc1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm3009103
9890440 22570 0 None None None Human 8.6 pIC50 = 8.6 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 460 6 1 7 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(C)c2)cc1 10.1021/jm9606507
CHEMBL10924 22570 0 None None None Human 8.6 pIC50 = 8.6 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 460 6 1 7 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(OC)c(C)c2)cc1 10.1021/jm9606507
10577306 219250 0 None None None Rat 8.6 pIC50 = 8.6 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 499 13 1 7 3.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ncco1 10.1021/jm980217s
CHEMBL322732 219250 0 None None None Rat 8.6 pIC50 = 8.6 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 499 13 1 7 3.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ncco1 10.1021/jm980217s
44315007 469447 0 None None None Pig 8.6 pIC50 = 8.6 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 679 14 5 5 5.1 CCCSCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL72891 469447 0 None None None Pig 8.6 pIC50 = 8.6 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 679 14 5 5 5.1 CCCSCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
21041273 347829 0 None None None Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 538 12 2 9 2.8 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(OC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4536769 347829 0 None None None Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 538 12 2 9 2.8 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(OC)cn2)c1-c1ccc(Br)cc1 10.1016/j.bmcl.2016.06.014
9821701 18956 0 None None None Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 389 4 1 5 3.8 COc1ccc([C@@H]2c3ncccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
CHEMBL102825 18956 0 None None None Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 389 4 1 5 3.8 COc1ccc([C@@H]2c3ncccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
10698065 26384 0 None None None Human 8.6 pIC50 = 8.6 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 558 11 2 6 5.6 CCC(CC)C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm990171i
CHEMBL1184065 26384 0 None None None Human 8.6 pIC50 = 8.6 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 558 11 2 6 5.6 CCC(CC)C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm990171i
CHEMBL171198 484756 0 None None None Human 8.6 pIC50 = 8.6 Binding
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 603 12 4 5 4.0 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)O 10.1016/0960-894X(95)00144-I
10529742 22508 0 None None None Rat 8.6 pIC50 = 8.6 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 511 13 1 6 4.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1cccn1C 10.1021/jm980217s
CHEMBL109206 22508 0 None None None Rat 8.6 pIC50 = 8.6 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 511 13 1 6 4.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1cccn1C 10.1021/jm980217s
10116355 22582 0 None None None Rat 8.6 pIC50 = 8.6 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 474 14 1 5 4.9 CCCCC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
CHEMBL109248 22582 0 None None None Rat 8.6 pIC50 = 8.6 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 474 14 1 5 4.9 CCCCC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
10648715 219233 0 None None None Rat 8.6 pIC50 = 8.6 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 488 14 1 5 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCC(C)C 10.1021/jm980217s
CHEMBL322547 219233 0 None None None Rat 8.6 pIC50 = 8.6 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 488 14 1 5 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCC(C)C 10.1021/jm980217s
44320291 215623 0 None None None Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 548 7 2 8 4.8 O=C(O)c1cc2c(c(Cn3nc(-c4ccccc4)c(Cc4cc5c(cc4Cl)OCO5)c3C(=O)O)c1)OCOC2 10.1016/s0960-894x(00)00513-8
CHEMBL312854 215623 0 None None None Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 548 7 2 8 4.8 O=C(O)c1cc2c(c(Cn3nc(-c4ccccc4)c(Cc4cc5c(cc4Cl)OCO5)c3C(=O)O)c1)OCOC2 10.1016/s0960-894x(00)00513-8
17885912 216743 0 None None None Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 496 7 2 6 5.1 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1CCCC(C(=O)O)C1 10.1016/s0960-894x(00)00513-8
CHEMBL315936 216743 0 None None None Rat 8.6 pIC50 = 8.6 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 496 7 2 6 5.1 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1CCCC(C(=O)O)C1 10.1016/s0960-894x(00)00513-8
44279295 215686 0 None None None Human 8.6 pIC50 = 8.6 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 482 8 1 6 4.2 COc1nc(C)cnc1NS(=O)(=O)c1cccc(C(=O)N(C)C)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
CHEMBL31324 215686 0 None None None Human 8.6 pIC50 = 8.6 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 482 8 1 6 4.2 COc1nc(C)cnc1NS(=O)(=O)c1cccc(C(=O)N(C)C)c1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
10670600 196912 0 None None None Human 8.6 pIC50 = 8.6 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 436 6 2 6 3.6 CCNc1cccc2c(S(=O)(=O)Nc3ncc(Br)nc3OC)cccc12 10.1021/jm9604585
CHEMBL263079 196912 0 None None None Human 8.6 pIC50 = 8.6 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 436 6 2 6 3.6 CCNc1cccc2c(S(=O)(=O)Nc3ncc(Br)nc3OC)cccc12 10.1021/jm9604585
10646831 367247 0 None None None Human 8.6 pIC50 = 8.6 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 441 6 2 7 4.1 COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1021/jm9608366
10646831 367247 0 None None None Human 8.6 pIC50 = 8.6 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 441 6 2 7 4.1 COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1021/jm9700068
CHEMBL48134 367247 0 None None None Human 8.6 pIC50 = 8.6 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 441 6 2 7 4.1 COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1021/jm9608366
CHEMBL48134 367247 0 None None None Human 8.6 pIC50 = 8.6 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 441 6 2 7 4.1 COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1021/jm9700068
11751754 202443 0 None None None Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 469 6 3 7 4.1 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)O)c1 10.1021/jm030528p
CHEMBL303806 202443 0 None None None Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 469 6 3 7 4.1 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C(=O)O)c1 10.1021/jm030528p
10555516 23546 0 None None None Rat 8.6 pIC50 = 8.6 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 598 12 1 7 4.6 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)Cc1ccccc1 10.1021/jm970101g
CHEMBL110700 23546 0 None None None Rat 8.6 pIC50 = 8.6 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 598 12 1 7 4.6 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)c(F)c1)S(=O)(=O)Cc1ccccc1 10.1021/jm970101g
11799503 24056 0 None None None Rat 8.6 pIC50 = 8.6 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 498 13 1 6 4.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccco1 10.1021/jm980217s
CHEMBL113472 24056 0 None None None Rat 8.6 pIC50 = 8.6 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 498 13 1 6 4.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCc1ccco1 10.1021/jm980217s
10289311 219970 0 None None None Rat 8.6 pIC50 = 8.6 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 514 13 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)C=C(C)C 10.1021/jm980217s
CHEMBL324586 219970 0 None None None Rat 8.6 pIC50 = 8.6 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 514 13 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)C=C(C)C 10.1021/jm980217s
CHEMBL2304007 485309 0 None None None Pig 8.6 pIC50 = 8.6 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 636 6 6 6 1.3 Cc1[nH]c2ccccc2c1C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C2CCCC2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC1=O 10.1021/jm9600914
44380954 120471 0 None None None Pig 8.6 pIC50 = 8.6 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 643 11 1 10 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOc1ncc(Br)cn1 10.1016/s0960-894x(01)00682-5
CHEMBL166875 120471 0 None None None Pig 8.6 pIC50 = 8.6 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 643 11 1 10 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOc1ncc(Br)cn1 10.1016/s0960-894x(01)00682-5
10525281 366228 0 None None None Human 8.6 pIC50 = 8.6 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 404 6 1 6 4.2 Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1021/jm9700068
CHEMBL47915 366228 0 None None None Human 8.6 pIC50 = 8.6 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 404 6 1 6 4.2 Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1021/jm9700068
9888574 213895 0 None None None Human 8.6 pIC50 = 8.6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 422 4 1 4 3.9 CCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL309692 213895 0 None None None Human 8.6 pIC50 = 8.6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 422 4 1 4 3.9 CCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
11102844 468275 0 None None None Rat 8.6 pIC50 = 8.6 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 476 7 2 7 4.2 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)CO)cc32)cc1 10.1021/jm010382z
CHEMBL64536 468275 0 None None None Rat 8.6 pIC50 = 8.6 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 476 7 2 7 4.2 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)CO)cc32)cc1 10.1021/jm010382z
44314906 213305 0 None None None Pig 8.6 pIC50 = 8.6 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 607 12 6 5 3.4 Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)NC(Cc1c[nH]cn1)C(=O)O 10.1021/jm9600914
CHEMBL308621 213305 0 None None None Pig 8.6 pIC50 = 8.6 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 607 12 6 5 3.4 Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)NC(Cc1c[nH]cn1)C(=O)O 10.1021/jm9600914
44458670 199280 0 None None None Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 521 7 2 8 2.7 COc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 10.1016/s0960-894x(01)00660-6
CHEMBL280379 199280 0 None None None Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 521 7 2 8 2.7 COc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(N)=O)ccc23)cc1 10.1016/s0960-894x(01)00660-6
71455060 163092 0 None None None Human 8.6 pIC50 = 8.6 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 614 9 1 9 2.9 O=S(=O)(Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1)N1CCOCC1 10.1021/jm3009103
CHEMBL2163689 163092 0 None None None Human 8.6 pIC50 = 8.6 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 614 9 1 9 2.9 O=S(=O)(Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1)N1CCOCC1 10.1021/jm3009103
71451526 163104 0 None None None Human 8.6 pIC50 = 8.6 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 635 14 1 12 4.6 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Cl)cn1 10.1021/jm3009103
CHEMBL2163701 163104 0 None None None Human 8.6 pIC50 = 8.6 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 635 14 1 12 4.6 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Cl)cn1 10.1021/jm3009103
10875868 233953 0 None None None Pig 8.6 pIC50 = 8.6 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 619 9 1 8 5.0 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(Br)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
CHEMBL334263 233953 0 None None None Pig 8.6 pIC50 = 8.6 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 619 9 1 8 5.0 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(Br)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
9810190 203115 0 None None None Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 563 11 1 10 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCN(C)C)c2)cc1 10.1021/jm980504w
CHEMBL307330 203115 0 None None None Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 563 11 1 10 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCN(C)C)c2)cc1 10.1021/jm980504w
CHEMBL2304015 485317 0 None None None Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL 634 6 6 6 1.0 Cc1[nH]c2ccccc2c1C[C@@H]1NC(=O)[C@@H](C2CC2)NC(=O)[C@H](C2CCCC2)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC1=O 10.1021/jm9600914
10875239 23891 0 None None None Pig 8.5 pIC50 = 8.5 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 541 10 1 10 4.8 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccco2)nc1 10.1021/jm0102304
CHEMBL112502 23891 0 None None None Pig 8.5 pIC50 = 8.5 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 541 10 1 10 4.8 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccco2)nc1 10.1021/jm0102304
10791823 23753 0 None None None Rat 7.7 pIC50 = 7.7 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 510 12 1 6 4.7 CCCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)C(=O)CCC 10.1021/jm970101g
CHEMBL111783 23753 0 None None None Rat 7.7 pIC50 = 7.7 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 510 12 1 6 4.7 CCCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)C(=O)CCC 10.1021/jm970101g
15289330 199990 0 None None None Human 7.7 pIC50 = 7.7 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 493 8 1 8 5.3 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OC)cc23)c1 10.1016/0960-894X(96)00232-6
CHEMBL285368 199990 0 None None None Human 7.7 pIC50 = 7.7 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 493 8 1 8 5.3 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OC)cc23)c1 10.1016/0960-894X(96)00232-6
10361107 317546 0 None None None Rat 7.7 pIC50 = 7.7 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 5 2 5 4.1 Cc1noc(NS(=O)(=O)c2cccc3c(NC(C)C)cccc23)c1C 10.1021/jm00008a013
CHEMBL416026 317546 0 None None None Rat 7.7 pIC50 = 7.7 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 5 2 5 4.1 Cc1noc(NS(=O)(=O)c2cccc3c(NC(C)C)cccc23)c1C 10.1021/jm00008a013
44314658 470029 0 None None None Pig 7.7 pIC50 = 7.7 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 589 13 5 4 4.7 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CCC)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL78230 470029 0 None None None Pig 7.7 pIC50 = 7.7 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 589 13 5 4 4.7 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CCC)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
9951753 331165 0 None None None Rat 7.7 pIC50 = 7.7 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 379 7 1 5 4.7 Cc1ccccc1C(Oc1cc(OCc2ccsc2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL427294 331165 0 None None None Rat 7.7 pIC50 = 7.7 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 379 7 1 5 4.7 Cc1ccccc1C(Oc1cc(OCc2ccsc2)ccc1C#N)C(=O)O 10.1021/jm990378b
11797717 473986 0 None None None Rat 7.7 pIC50 = 7.7 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 448 10 2 5 6.0 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1cc[nH]n1 10.1021/jm9707131
CHEMBL91753 473986 0 None None None Rat 7.7 pIC50 = 7.7 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 448 10 2 5 6.0 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1cc[nH]n1 10.1021/jm9707131
10668808 474076 0 None None None Rat 7.7 pIC50 = 7.7 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 402 9 1 5 4.8 Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2ccncc2)ccc1C#N 10.1021/jm9707131
CHEMBL92353 474076 0 None None None Rat 7.7 pIC50 = 7.7 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 402 9 1 5 4.8 Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2ccncc2)ccc1C#N 10.1021/jm9707131
10694804 474689 0 None None None Rat 7.7 pIC50 = 7.7 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 449 10 1 6 6.3 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1ncco1 10.1021/jm9707131
CHEMBL96301 474689 0 None None None Rat 7.7 pIC50 = 7.7 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 449 10 1 6 6.3 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1ncco1 10.1021/jm9707131
10695071 201292 0 None None None Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 454 6 1 6 4.3 Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9700068
CHEMBL295477 201292 0 None None None Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 454 6 1 6 4.3 Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9700068
10672494 353444 0 None None None Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 483 6 2 6 5.0 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(C(C)C)cc2)c1Br 10.1021/jm9608366
CHEMBL47417 353444 0 None None None Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 483 6 2 6 5.0 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(C(C)C)cc2)c1Br 10.1021/jm9608366
44327412 474466 0 None None None Rat 7.7 pIC50 = 7.7 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 497 5 1 8 3.0 Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL94929 474466 0 None None None Rat 7.7 pIC50 = 7.7 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 497 5 1 8 3.0 Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL343062 487088 0 None None None Pig 7.7 pIC50 = 7.7 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 628 7 6 7 0.7 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
101039204 1466 45 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm3009103
443289 1466 45 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm3009103
997 1466 45 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm3009103
CHEMBL314691 1466 45 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm3009103
CHEMBL4095638 1466 45 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm3009103
DB12054 1466 45 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm3009103
44320431 216611 0 None None None Rat 7.7 pIC50 = 7.7 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 526 9 2 7 4.9 O=C(O)COC1CCCCC1Cn1nc(-c2ccccc2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O 10.1016/s0960-894x(00)00513-8
CHEMBL314973 216611 0 None None None Rat 7.7 pIC50 = 7.7 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 526 9 2 7 4.9 O=C(O)COC1CCCCC1Cn1nc(-c2ccccc2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O 10.1016/s0960-894x(00)00513-8
10767442 259112 0 None None None Rat 6.7 pIC50 = 6.7 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 492 8 1 5 6.1 COc1ccc(C(=O)/C(Cc2ccc(-c3ccccc3)cc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
CHEMBL368668 259112 0 None None None Rat 6.7 pIC50 = 6.7 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 492 8 1 5 6.1 COc1ccc(C(=O)/C(Cc2ccc(-c3ccccc3)cc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
CHEMBL313984 486534 0 None None None Human 6.7 pIC50 = 6.7 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 881 24 9 8 2.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL265116 486147 0 None None None Human 6.7 pIC50 = 6.7 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 957 25 9 8 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
10815005 24051 0 None None None Human 6.7 pIC50 = 6.7 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 492 6 1 6 5.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(-c3ccccc3)cc2)cc1 10.1021/jm9606507
CHEMBL11345 24051 0 None None None Human 6.7 pIC50 = 6.7 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 492 6 1 6 5.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(-c3ccccc3)cc2)cc1 10.1021/jm9606507
10506430 232818 0 None None None Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 532 9 2 7 4.5 CCc1cccc(OC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
CHEMBL332387 232818 0 None None None Human 6.7 pIC50 = 6.7 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 532 9 2 7 4.5 CCc1cccc(OC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
10669001 222101 0 None None None Rat 6.7 pIC50 = 6.7 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 405 6 1 6 4.6 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/C(=O)O)c1ccc2c(c1)OCO2 10.1021/jm970847e
CHEMBL330255 222101 0 None None None Rat 6.7 pIC50 = 6.7 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 405 6 1 6 4.6 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/C(=O)O)c1ccc2c(c1)OCO2 10.1021/jm970847e
10692108 332894 0 None None None Rat 6.7 pIC50 = 6.7 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 395 6 1 4 5.5 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/C(=O)O)c1ccccc1Cl 10.1021/jm970847e
CHEMBL433201 332894 0 None None None Rat 6.7 pIC50 = 6.7 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 395 6 1 4 5.5 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/C(=O)O)c1ccccc1Cl 10.1021/jm970847e
CHEMBL313984 486534 0 None None None Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cellsDisplacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cells
ChEMBL 881 24 9 8 2.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81215-4
10577255 349421 0 None None None Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 497 8 2 6 5.2 CCCCc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9608366
CHEMBL45760 349421 0 None None None Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 497 8 2 6 5.2 CCCCc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9608366
CHEMBL1793926 484837 0 None None None Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 25 8 8 4.5 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm970161m
10769045 259106 0 None None None Rat 6.7 pIC50 = 6.7 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 4 6 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2(C)CCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL368641 259106 0 None None None Rat 6.7 pIC50 = 6.7 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 4 6 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2(C)CCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL134562 484654 0 None None None Pig 6.7 pIC50 = 6.7 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 641 11 8 7 0.5 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL436899 488642 0 None None None Human 5.7 pIC50 = 5.7 Binding
Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)
ChEMBL 1583 32 20 21 -1.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
CHEMBL407933 487995 0 None None None Human 5.7 pIC50 = 5.7 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 1007 26 10 8 5.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)NC1CCCCC1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
18617284 470066 0 None None None Human 5.7 pIC50 = 5.7 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 350 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL78552 470066 0 None None None Human 5.7 pIC50 = 5.7 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 350 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2)c1Br 10.1016/0960-894X(96)00441-6
44283270 202968 0 None None None Pig 5.7 pIC50 = 5.7 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 580 12 5 5 3.8 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1021/jm9600914
44314579 202968 0 None None None Pig 5.7 pIC50 = 5.7 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 580 12 5 5 3.8 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1021/jm9600914
CHEMBL306123 202968 0 None None None Pig 5.7 pIC50 = 5.7 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 580 12 5 5 3.8 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1021/jm9600914
CHEMBL431124 202968 0 None None None Pig 5.7 pIC50 = 5.7 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 580 12 5 5 3.8 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1021/jm9600914
10549516 219923 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 410 8 1 4 3.4 CCCN(C)C(=O)CN1C[C@H](c2ccccc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL324301 219923 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 410 8 1 4 3.4 CCCN(C)C(=O)CN1C[C@H](c2ccccc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
22010208 474018 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 362 9 1 3 5.3 O=C(O)CCC(Oc1cccc(OCc2ccccc2)c1)c1ccccc1 10.1021/jm970847e
CHEMBL91965 474018 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 362 9 1 3 5.3 O=C(O)CCC(Oc1cccc(OCc2ccccc2)c1)c1ccccc1 10.1021/jm970847e
10717670 474108 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 433 7 1 5 5.7 O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1[N+](=O)[O-])c1c(F)cccc1Cl 10.1021/jm970847e
CHEMBL92570 474108 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 433 7 1 5 5.7 O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1[N+](=O)[O-])c1c(F)cccc1Cl 10.1021/jm970847e
19735404 349801 0 None None None Human 5.7 pIC50 = 5.7 Binding
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 471 9 2 7 3.5 COc1ccccc1Cc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL4584753 349801 0 None None None Human 5.7 pIC50 = 5.7 Binding
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 471 9 2 7 3.5 COc1ccccc1Cc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCO 10.1016/j.bmcl.2016.06.014
10528383 25515 0 None None None Human 5.7 pIC50 = 5.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 470 5 1 8 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)c2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
CHEMBL1178854 25515 0 None None None Human 5.7 pIC50 = 5.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 470 5 1 8 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)c2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
10604797 202426 0 None None None Human 5.7 pIC50 = 5.7 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 704 14 1 13 3.3 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OCCN3CCOCC3)c(OC)c(OCCN3CCOCC3)c2)cc1 10.1021/jm980504w
CHEMBL303712 202426 0 None None None Human 5.7 pIC50 = 5.7 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 704 14 1 13 3.3 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OCCN3CCOCC3)c(OC)c(OCCN3CCOCC3)c2)cc1 10.1021/jm980504w
10238141 392010 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 429 5 1 6 4.2 COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc3c(c2)OCO3)c2ccccc21 10.1016/S0960-894X(97)00319-3
CHEMBL55853 392010 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 429 5 1 6 4.2 COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc3c(c2)OCO3)c2ccccc21 10.1016/S0960-894X(97)00319-3
44283270 202968 0 None None None Pig 5.7 pIC50 = 5.7 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 580 12 5 5 3.8 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1016/0960-894X(95)00237-N
44314579 202968 0 None None None Pig 5.7 pIC50 = 5.7 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 580 12 5 5 3.8 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1016/0960-894X(95)00237-N
CHEMBL306123 202968 0 None None None Pig 5.7 pIC50 = 5.7 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 580 12 5 5 3.8 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1016/0960-894X(95)00237-N
CHEMBL431124 202968 0 None None None Pig 5.7 pIC50 = 5.7 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 580 12 5 5 3.8 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1016/0960-894X(95)00237-N
10357554 197867 0 None None None Human 4.7 pIC50 = 4.7 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 302 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C 10.1021/jm00029a001
CHEMBL27065 197867 0 None None None Human 4.7 pIC50 = 4.7 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 302 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C 10.1021/jm00029a001
44278161 199992 0 None None None Human 4.7 pIC50 = 4.7 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 569 10 1 8 6.9 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OCc4ccccc4)c(OC)cc23)c1 10.1016/0960-894X(96)00232-6
CHEMBL285380 199992 0 None None None Human 4.7 pIC50 = 4.7 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 569 10 1 8 6.9 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OCc4ccccc4)c(OC)cc23)c1 10.1016/0960-894X(96)00232-6
10357554 197867 0 None None None Rat 4.7 pIC50 = 4.7 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 302 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C 10.1021/jm00008a013
CHEMBL27065 197867 0 None None None Rat 4.7 pIC50 = 4.7 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 302 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C 10.1021/jm00008a013
10495634 474790 0 None None None Rat 4.7 pIC50 = 4.7 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 316 6 1 2 4.8 OC/C(=C/c1cccc(OCc2ccccc2)c1)c1ccccc1 10.1021/jm970847e
CHEMBL96836 474790 0 None None None Rat 4.7 pIC50 = 4.7 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 316 6 1 2 4.8 OC/C(=C/c1cccc(OCc2ccccc2)c1)c1ccccc1 10.1021/jm970847e
44276966 216515 0 None None None Rat 4.7 pIC50 = 4.7 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 352 5 1 5 2.9 COc1cccc(Cn2[nH]c(C)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144846 216515 0 None None None Rat 4.7 pIC50 = 4.7 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 352 5 1 5 2.9 COc1cccc(Cn2[nH]c(C)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
44386894 125220 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 412 7 2 6 2.1 COc1ccc([C@@H]2[C@@H](CC(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(N)=O)cc1 10.1021/jm031041j
CHEMBL177999 125220 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 412 7 2 6 2.1 COc1ccc([C@@H]2[C@@H](CC(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(N)=O)cc1 10.1021/jm031041j
11795139 331352 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 398 6 2 6 1.8 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(N)=O)cc1 10.1021/jm9505369
CHEMBL427935 331352 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 398 6 2 6 1.8 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(N)=O)cc1 10.1021/jm9505369
10212163 258010 0 None None None Human 6.7 pIC50 = 6.7 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 696 11 2 13 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
CHEMBL367767 258010 0 None None None Human 6.7 pIC50 = 6.7 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 696 11 2 13 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOC(=O)Nc1cnccn1 10.1016/s0960-894x(02)01084-3
23445256 122961 0 None None None Human 6.7 pIC50 = 6.7 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 470 6 1 7 4.1 Cc1noc(NS(=O)(=O)c2ccsc2CCc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
CHEMBL173982 122961 0 None None None Human 6.7 pIC50 = 6.7 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 470 6 1 7 4.1 Cc1noc(NS(=O)(=O)c2ccsc2CCc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
10604119 25734 0 None None None Human 4.7 pIC50 = 4.7 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 636 12 2 7 5.8 COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 10.1021/jm990171i
CHEMBL1180361 25734 0 None None None Human 4.7 pIC50 = 4.7 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 636 12 2 7 5.8 COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 10.1021/jm990171i
44325305 474358 0 None None None Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 426 10 2 5 5.3 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C(=O)O 10.1021/jm9707131
CHEMBL94279 474358 0 None None None Rat 6.7 pIC50 = 6.7 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 426 10 2 5 5.3 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C(=O)O 10.1021/jm9707131
10005597 238532 0 None None None Rat 7.7 pIC50 = 7.7 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 485 7 1 7 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cc(OC)ccc3OC)c3c2oc2ccccc23)cc1 10.1021/jm031041j
CHEMBL348407 238532 0 None None None Rat 7.7 pIC50 = 7.7 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 485 7 1 7 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cc(OC)ccc3OC)c3c2oc2ccccc23)cc1 10.1021/jm031041j
10005597 238532 0 None None None Rat 7.7 pIC50 = 7.7 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 485 7 1 7 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cc(OC)ccc3OC)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL348407 238532 0 None None None Rat 7.7 pIC50 = 7.7 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 485 7 1 7 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cc(OC)ccc3OC)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL433349 488587 0 None None None Human 7.7 pIC50 = 7.7 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 937 26 9 8 4.6 CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
44314890 214777 0 None None None Pig 7.7 pIC50 = 7.7 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 647 12 5 4 5.0 CC(C)CC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL311384 214777 0 None None None Pig 7.7 pIC50 = 7.7 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 647 12 5 4 5.0 CC(C)CC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
3539 8957 55 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 424 6 1 9 2.7 COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 10.1016/j.bmcl.2016.06.014
9910224 8957 55 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 424 6 1 9 2.7 COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 10.1016/j.bmcl.2016.06.014
CHEMBL1628688 8957 55 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 424 6 1 9 2.7 COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 10.1016/j.bmcl.2016.06.014
DB06629 8957 55 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 424 6 1 9 2.7 COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 10.1016/j.bmcl.2016.06.014
10168597 124097 0 None None None Human 7.7 pIC50 = 7.7 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cccnc1 10.1016/s0960-894x(02)01084-3
CHEMBL176741 124097 0 None None None Human 7.7 pIC50 = 7.7 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 661 11 2 13 3.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)Nc1cccnc1 10.1016/s0960-894x(02)01084-3
10673969 124855 0 None None None Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 538 10 3 7 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL177546 124855 0 None None None Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 538 10 3 7 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
10138169 199569 0 None None None Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 440 6 1 8 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1Cl 10.1021/jm000349x
CHEMBL282470 199569 0 None None None Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 440 6 1 8 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1Cl 10.1021/jm000349x
CHEMBL342615 487067 0 None None None Pig 7.7 pIC50 = 7.7 Binding
Inhibitory effect against porcine Endothelin A receptorInhibitory effect against porcine Endothelin A receptor
ChEMBL 646 7 6 7 0.2 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL342615 487067 0 None None None Pig 7.7 pIC50 = 7.7 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 646 7 6 7 0.2 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10527706 197325 0 None None None Human 7.7 pIC50 = 7.7 Binding
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 454 8 1 6 3.1 CCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL266594 197325 0 None None None Human 7.7 pIC50 = 7.7 Binding
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 454 8 1 6 3.1 CCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
44439114 317169 0 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 993 32 2 15 7.3 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOc2ccc(CCC(=O)N(C)Cc3cc(-c4ncco4)ccc3-c3ccccc3S(=O)(=O)Nc3ccno3)cc2)cc1 10.1016/j.bmcl.2006.10.009
CHEMBL413001 317169 0 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 993 32 2 15 7.3 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOc2ccc(CCC(=O)N(C)Cc3cc(-c4ncco4)ccc3-c3ccccc3S(=O)(=O)Nc3ccno3)cc2)cc1 10.1016/j.bmcl.2006.10.009
18738889 178829 0 None None None Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 562 8 1 8 4.9 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)OC)cc21 10.1016/s0960-894x(01)00660-6
CHEMBL23418 178829 0 None None None Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 562 8 1 8 4.9 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)OC)cc21 10.1016/s0960-894x(01)00660-6
10310877 468863 0 None None None Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 473 8 1 7 5.9 CCCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)n2Cc1ccc2nsnc2c1 10.1016/s0960-894x(97)10151-2
CHEMBL68896 468863 0 None None None Rat 6.7 pIC50 = 6.7 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 473 8 1 7 5.9 CCCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)n2Cc1ccc2nsnc2c1 10.1016/s0960-894x(97)10151-2
CHEMBL136210 484660 0 None None None Pig 6.7 pIC50 = 6.7 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 660 9 7 6 1.6 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
21462927 238913 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 500 7 1 8 5.1 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2cc([N+](=O)[O-])ccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL352241 238913 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 500 7 1 8 5.1 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2cc([N+](=O)[O-])ccc23)cc1 10.1016/s0960-894x(99)00040-2
10086660 199383 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 309 6 2 5 2.9 CCCNc1cccc(S(=O)(=O)Nc2onc(C)c2C)c1 10.1021/jm00008a013
CHEMBL281199 199383 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 309 6 2 5 2.9 CCCNc1cccc(S(=O)(=O)Nc2onc(C)c2C)c1 10.1021/jm00008a013
44279308 200308 0 None None None Pig 5.7 pIC50 = 5.7 Binding
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 521 12 6 4 3.3 Cc1cccc(NC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCCC(=O)O)c1 10.1016/0960-894X(95)00221-E
CHEMBL287676 200308 0 None None None Pig 5.7 pIC50 = 5.7 Binding
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 521 12 6 4 3.3 Cc1cccc(NC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCCC(=O)O)c1 10.1016/0960-894X(95)00221-E
44279307 217637 0 None None None Pig 5.7 pIC50 = 5.7 Binding
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 541 12 6 4 3.7 CC(C)C[C@H](NC(=O)Nc1cccc(Cl)c1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31944 217637 0 None None None Pig 5.7 pIC50 = 5.7 Binding
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 541 12 6 4 3.7 CC(C)C[C@H](NC(=O)Nc1cccc(Cl)c1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL319537 486628 0 None None None Human 5.7 pIC50 = 5.7 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 881 24 9 8 4.0 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10621049 474148 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 400 6 1 3 5.6 OC/C(=C/c1cc(OCc2ccsc2)ccc1Br)c1ccccc1 10.1021/jm970847e
CHEMBL92876 474148 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 400 6 1 3 5.6 OC/C(=C/c1cc(OCc2ccsc2)ccc1Br)c1ccccc1 10.1021/jm970847e
44213278 216508 0 None None None Rat 5.7 pIC50 = 5.7 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 406 5 1 5 3.6 COc1ccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)cc1 10.1016/s0960-894x(00)00232-8
CHEMBL3144799 216508 0 None None None Rat 5.7 pIC50 = 5.7 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 406 5 1 5 3.6 COc1ccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)cc1 10.1016/s0960-894x(00)00232-8
10719007 25521 0 None None None Human 5.7 pIC50 = 5.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 465 6 1 9 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)C(C#N)c2ccc3c(c2)OCO3)c1Cl 10.1021/jm9700068
CHEMBL1178895 25521 0 None None None Human 5.7 pIC50 = 5.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 465 6 1 9 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)C(C#N)c2ccc3c(c2)OCO3)c1Cl 10.1021/jm9700068
10626054 259237 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 530 11 6 4 4.2 Cc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NCc2ccccc2)nc1C(=O)O 10.1021/jm950592+
CHEMBL368788 259237 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 530 11 6 4 4.2 Cc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NCc2ccccc2)nc1C(=O)O 10.1021/jm950592+
CHEMBL1206645 484537 0 None None None Pig 4.7 pIC50 = 4.7 Binding
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL 751 16 5 6 4.5 CC(C)C[C@@H](NC(=O)N1CCCCCC1)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00087a001
CHEMBL290454 484537 0 None None None Pig 4.7 pIC50 = 4.7 Binding
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL 751 16 5 6 4.5 CC(C)C[C@@H](NC(=O)N1CCCCCC1)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00087a001
10742968 26630 0 None None None Human 4.7 pIC50 = 4.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 469 7 1 8 4.1 Cc1noc(NS(=O)(=O)c2ccsc2C(Cc2ccc3c(c2)OCO3)N(C)C)c1Cl 10.1021/jm9700068
CHEMBL1185472 26630 0 None None None Human 4.7 pIC50 = 4.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 469 7 1 8 4.1 Cc1noc(NS(=O)(=O)c2ccsc2C(Cc2ccc3c(c2)OCO3)N(C)C)c1Cl 10.1021/jm9700068
44368481 240123 0 None None None Pig 4.7 pIC50 = 4.7 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 435 9 2 7 2.8 CCOC(=O)CN(Cc1cc2c(cc1Cl)OCO2)C(Cc1ccc(O)cc1)C(=O)O 10.1016/s0960-894x(01)00009-9
CHEMBL358444 240123 0 None None None Pig 4.7 pIC50 = 4.7 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 435 9 2 7 2.8 CCOC(=O)CN(Cc1cc2c(cc1Cl)OCO2)C(Cc1ccc(O)cc1)C(=O)O 10.1016/s0960-894x(01)00009-9
10576888 335390 0 None None None Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 485 6 3 7 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2C(=O)O)c1Br 10.1021/jm9608366
CHEMBL44539 335390 0 None None None Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 485 6 3 7 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2C(=O)O)c1Br 10.1021/jm9608366
23445284 222272 0 None None None Human 6.7 pIC50 = 6.7 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 440 5 1 5 5.4 Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(C(C)C)cc2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL330674 222272 0 None None None Human 6.7 pIC50 = 6.7 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 440 5 1 5 5.4 Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(C(C)C)cc2)c1Br 10.1016/S0960-894X(96)00496-9
23445458 123070 0 None None None Human 6.7 pIC50 = 6.7 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 468 5 1 7 4.5 Cc1noc(NS(=O)(=O)c2sccc2/C=C/c2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
CHEMBL174363 123070 0 None None None Human 6.7 pIC50 = 6.7 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 468 5 1 7 4.5 Cc1noc(NS(=O)(=O)c2sccc2/C=C/c2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
2529 347569 76 None None None Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C nan
5344 347569 76 None None None Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C nan
CHEMBL453 347569 76 None None None Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C nan
DB00263 347569 76 None None None Human 4.7 pIC50 = 4.7 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C nan
44385412 259263 0 None None None Human 5.7 pIC50 = 5.7 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 711 14 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(Cc2ccc3c(c2)OCO3)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL368945 259263 0 None None None Human 5.7 pIC50 = 5.7 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 711 14 2 13 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(Cc2ccc3c(c2)OCO3)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
18184249 256412 0 None None None Human 5.7 pIC50 = 5.7 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 662 13 2 11 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccncc2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL366628 256412 0 None None None Human 5.7 pIC50 = 5.7 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 662 13 2 11 4.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccncc2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL303185 484251 0 None None None Pig 7.7 pIC50 = 7.7 Binding
Binding activity against Endothelin A receptor of Porcine aortic smooth muscle membranesBinding activity against Endothelin A receptor of Porcine aortic smooth muscle membranes
ChEMBL 610 7 6 6 0.8 CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00089a028
10696818 23954 0 None None None Rat 7.7 pIC50 = 7.7 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 502 15 1 5 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC(CC)CC 10.1021/jm980217s
CHEMBL112770 23954 0 None None None Rat 7.7 pIC50 = 7.7 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 502 15 1 5 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC(CC)CC 10.1021/jm980217s
CHEMBL303185 484251 0 None None None Pig 7.7 pIC50 = 7.7 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 610 7 6 6 0.8 CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm9600914
10792711 233789 0 None None None Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 548 9 2 6 5.2 CCc1cc(F)cc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
CHEMBL333972 233789 0 None None None Human 7.7 pIC50 = 7.7 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 548 9 2 6 5.2 CCc1cc(F)cc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
9917706 257655 0 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 659 15 2 11 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/j.bmcl.2016.06.014
CHEMBL367444 257655 0 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 659 15 2 11 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/j.bmcl.2016.06.014
18738881 161062 0 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 534 7 2 7 4.4 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(=O)O)ccc23)cc1 10.1016/s0960-894x(01)00660-6
CHEMBL2114305 161062 0 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 534 7 2 7 4.4 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C(=O)O)ccc23)cc1 10.1016/s0960-894x(01)00660-6
101039204 1466 45 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm030528p
443289 1466 45 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm030528p
997 1466 45 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm030528p
CHEMBL314691 1466 45 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm030528p
CHEMBL4095638 1466 45 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm030528p
DB12054 1466 45 None None None Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm030528p
9886303 122317 0 None None None Rat 7.7 pIC50 = 7.7 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 383 7 1 5 4.5 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccccc1F 10.1021/jm990378b
CHEMBL171638 122317 0 None None None Rat 7.7 pIC50 = 7.7 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 383 7 1 5 4.5 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccccc1F 10.1021/jm990378b
44293761 333818 0 None None None Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 549 12 2 8 4.6 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCCCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL440853 333818 0 None None None Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 549 12 2 8 4.6 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCCCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
10908075 26018 0 None None None Pig 7.7 pIC50 = 7.7 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 591 9 1 8 5.4 Cc1ccc(-c2c(NS(=O)(=O)c3cccc4ccccc34)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
CHEMBL1181549 26018 0 None None None Pig 7.7 pIC50 = 7.7 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 591 9 1 8 5.4 Cc1ccc(-c2c(NS(=O)(=O)c3cccc4ccccc34)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
10302118 123191 0 None None None Human 7.7 pIC50 = 7.7 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 533 9 2 10 3.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccncc2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL175111 123191 0 None None None Human 7.7 pIC50 = 7.7 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 533 9 2 10 3.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccncc2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
135512539 256414 0 None None None Human 7.7 pIC50 = 7.7 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 615 11 2 13 4.4 C#CCOc1nc(-c2ccnc(-c3noc(O)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL366652 256414 0 None None None Human 7.7 pIC50 = 7.7 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 615 11 2 13 4.4 C#CCOc1nc(-c2ccnc(-c3noc(O)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
9864880 202463 0 None None None Rat 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 384 4 1 6 3.7 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc4nsnc4c3)cccc12 10.1016/s0960-894x(97)10151-2
CHEMBL303902 202463 0 None None None Rat 7.7 pIC50 = 7.7 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 384 4 1 6 3.7 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc4nsnc4c3)cccc12 10.1016/s0960-894x(97)10151-2
101039204 1466 45 None None None Pig 7.7 pIC50 = 7.7 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/0960-894X(95)00237-N
443289 1466 45 None None None Pig 7.7 pIC50 = 7.7 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/0960-894X(95)00237-N
997 1466 45 None None None Pig 7.7 pIC50 = 7.7 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/0960-894X(95)00237-N
CHEMBL314691 1466 45 None None None Pig 7.7 pIC50 = 7.7 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/0960-894X(95)00237-N
CHEMBL4095638 1466 45 None None None Pig 7.7 pIC50 = 7.7 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/0960-894X(95)00237-N
DB12054 1466 45 None None None Pig 7.7 pIC50 = 7.7 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/0960-894X(95)00237-N
10578601 256979 0 None None None Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 550 10 4 5 4.7 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)N(C)C(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL367033 256979 0 None None None Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 550 10 4 5 4.7 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)N(C)C(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
9917706 257655 0 None None None Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 659 15 2 11 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL367444 257655 0 None None None Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 659 15 2 11 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL336033 484275 0 None None None Pig 7.7 pIC50 = 7.7 Binding
Inhibitory effect against porcine Endothelin A receptorInhibitory effect against porcine Endothelin A receptor
ChEMBL 610 7 6 6 0.8 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL336033 484275 0 None None None Pig 7.7 pIC50 = 7.7 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 610 7 6 6 0.8 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL170121 484752 0 None None None Human 6.7 pIC50 = 6.7 Binding
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 513 10 4 5 2.4 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NCC(=O)O 10.1016/0960-894X(95)00144-I
11070564 468418 0 None None None Rat 6.7 pIC50 = 6.7 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 7 1 6 5.2 CCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)cc1)O2 10.1021/jm010382z
CHEMBL65494 468418 0 None None None Rat 6.7 pIC50 = 6.7 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 7 1 6 5.2 CCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)cc1)O2 10.1021/jm010382z
122044 24472 43 None None None Human 6.7 pIC50 = 6.7 Binding
Displacement of 125I-ET1 from human smooth muscle ETA receptor expressed in fall armyworm sf9 cell membranesDisplacement of 125I-ET1 from human smooth muscle ETA receptor expressed in fall armyworm sf9 cell membranes
ChEMBL 473 9 2 8 3.7 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)c1 10.1016/j.bmcl.2016.06.014
CHEMBL115951 24472 43 None None None Human 6.7 pIC50 = 6.7 Binding
Displacement of 125I-ET1 from human smooth muscle ETA receptor expressed in fall armyworm sf9 cell membranesDisplacement of 125I-ET1 from human smooth muscle ETA receptor expressed in fall armyworm sf9 cell membranes
ChEMBL 473 9 2 8 3.7 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)c1 10.1016/j.bmcl.2016.06.014
10571812 256584 0 None None None Rat 6.7 pIC50 = 6.7 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 380 7 1 6 4.1 Cc1ccccc1C(Oc1cc(OCc2ccsn2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL366788 256584 0 None None None Rat 6.7 pIC50 = 6.7 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 380 7 1 6 4.1 Cc1ccccc1C(Oc1cc(OCc2ccsn2)ccc1C#N)C(=O)O 10.1021/jm990378b
2802888 123324 8 None None None Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125]ET-1 binding to human Endothelin A receptor expressed in vero cellsInhibition of [125]ET-1 binding to human Endothelin A receptor expressed in vero cells
ChEMBL 414 9 4 5 2.5 CC(C)C(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccc(O)cc1)C(=O)O 10.1021/jm031041j
CHEMBL175916 123324 8 None None None Human 6.7 pIC50 = 6.7 Binding
Inhibition of [125]ET-1 binding to human Endothelin A receptor expressed in vero cellsInhibition of [125]ET-1 binding to human Endothelin A receptor expressed in vero cells
ChEMBL 414 9 4 5 2.5 CC(C)C(NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccc(O)cc1)C(=O)O 10.1021/jm031041j
10789279 473522 0 None None None Rat 6.7 pIC50 = 6.7 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 441 10 1 6 4.1 CCCCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL8878 473522 0 None None None Rat 6.7 pIC50 = 6.7 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 441 10 1 6 4.1 CCCCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10554384 333846 0 None None None Rat 6.7 pIC50 = 6.7 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 537 10 4 6 4.6 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL441112 333846 0 None None None Rat 6.7 pIC50 = 6.7 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 537 10 4 6 4.6 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm950592+
10554384 333846 0 None None None Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 537 10 4 6 4.6 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL441112 333846 0 None None None Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 537 10 4 6 4.6 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL2370254 485551 0 None None None Human 5.7 pIC50 = 5.7 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 900 25 9 9 3.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10024044 22156 0 None None None Human 5.7 pIC50 = 5.7 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 402 6 1 5 4.1 COc1ccc(CC2=C(c3ccccc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
CHEMBL10897 22156 0 None None None Human 5.7 pIC50 = 5.7 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 402 6 1 5 4.1 COc1ccc(CC2=C(c3ccccc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
11732155 466461 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 402 4 1 5 4.4 COc1ccccc1C1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm010382z
CHEMBL61460 466461 0 None None None Rat 5.7 pIC50 = 5.7 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 402 4 1 5 4.4 COc1ccccc1C1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm010382z
CHEMBL2304014 485316 0 None None None Pig 5.7 pIC50 = 5.7 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 621 6 6 7 0.3 CC(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(C#N)[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC1=O 10.1021/jm9600914
101039204 1466 45 None None None Pig 4.7 pIC50 = 4.7 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscleCompound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscle
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm00087a001
443289 1466 45 None None None Pig 4.7 pIC50 = 4.7 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscleCompound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscle
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm00087a001
997 1466 45 None None None Pig 4.7 pIC50 = 4.7 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscleCompound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscle
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm00087a001
CHEMBL314691 1466 45 None None None Pig 4.7 pIC50 = 4.7 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscleCompound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscle
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm00087a001
CHEMBL4095638 1466 45 None None None Pig 4.7 pIC50 = 4.7 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscleCompound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscle
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm00087a001
DB12054 1466 45 None None None Pig 4.7 pIC50 = 4.7 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscleCompound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscle
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm00087a001
10647488 350879 0 None None None Human 4.7 pIC50 = 4.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 456 6 2 8 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C(C)(O)Cc2ccc3c(c2)OCO3)c1Cl 10.1021/jm9700068
CHEMBL46195 350879 0 None None None Human 4.7 pIC50 = 4.7 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 456 6 2 8 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C(C)(O)Cc2ccc3c(c2)OCO3)c1Cl 10.1021/jm9700068
44320488 216640 0 None None None Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 438 5 1 5 5.7 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1C1CCCCC1 10.1016/s0960-894x(00)00513-8
CHEMBL315175 216640 0 None None None Rat 6.7 pIC50 = 6.7 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 438 5 1 5 5.7 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1C1CCCCC1 10.1016/s0960-894x(00)00513-8
10766198 327910 0 None None None Human 6.6 pIC50 = 6.6 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 6 2 6 3.5 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)NCc2ccccc2)c1Br 10.1021/jm9608366
CHEMBL417358 327910 0 None None None Human 6.6 pIC50 = 6.6 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 6 2 6 3.5 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)NCc2ccccc2)c1Br 10.1021/jm9608366
76324075 176757 0 None None None Rat 7.6 pIC50 = 7.6 Binding
Displacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hrDisplacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hr
ChEMBL 340 4 1 6 4.0 Cc1c(C(=O)O)oc2cccc(OCc3ccc4nsnc4c3)c12 10.1007/s00044-013-0542-3
CHEMBL2296899 176757 0 None None None Rat 7.6 pIC50 = 7.6 Binding
Displacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hrDisplacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hr
ChEMBL 340 4 1 6 4.0 Cc1c(C(=O)O)oc2cccc(OCc3ccc4nsnc4c3)c12 10.1007/s00044-013-0542-3
151174 467527 37 None None None Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 605 12 3 13 3.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccnc(-c3nn[nH]n3)c2)nc1OCCO 10.1021/jm030528p
CHEMBL61780 467527 37 None None None Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 605 12 3 13 3.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccnc(-c3nn[nH]n3)c2)nc1OCCO 10.1021/jm030528p
DB06558 467527 37 None None None Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]ET-1 from Endothelin A receptorDisplacement of [125I]ET-1 from Endothelin A receptor
ChEMBL 605 12 3 13 3.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccnc(-c3nn[nH]n3)c2)nc1OCCO 10.1021/jm030528p
10810505 122291 0 None None None Rat 7.6 pIC50 = 7.6 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 392 7 1 5 4.2 Cc1ccccc1C(Oc1cc(OCc2ccnc(F)c2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL171513 122291 0 None None None Rat 7.6 pIC50 = 7.6 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 392 7 1 5 4.2 Cc1ccccc1C(Oc1cc(OCc2ccnc(F)c2)ccc1C#N)C(=O)O 10.1021/jm990378b
10282163 123180 0 None None None Human 7.6 pIC50 = 7.6 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 599 11 2 12 3.9 C#CCOc1nc(-c2ccnc(-c3nn[nH]n3)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL175057 123180 0 None None None Human 7.6 pIC50 = 7.6 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 599 11 2 12 3.9 C#CCOc1nc(-c2ccnc(-c3nn[nH]n3)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10838921 473318 0 None None None Rat 7.6 pIC50 = 7.6 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 494 7 1 6 4.1 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)C2CCCCC2)cc1 10.1021/jm9505369
CHEMBL8736 473318 0 None None None Rat 7.6 pIC50 = 7.6 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 494 7 1 6 4.1 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)C2CCCCC2)cc1 10.1021/jm9505369
44279338 216355 0 None None None Pig 6.6 pIC50 = 6.6 Binding
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 487 11 6 4 2.3 CC(C)C[C@H](NC(=O)NC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31436 216355 0 None None None Pig 6.6 pIC50 = 6.6 Binding
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 487 11 6 4 2.3 CC(C)C[C@H](NC(=O)NC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL97431 489425 0 None None None Human 6.6 pIC50 = 6.6 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 923 25 9 8 4.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
18617403 470129 0 None None None Human 6.6 pIC50 = 6.6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 394 3 1 4 3.3 Cc1noc(NS(=O)(=O)c2cccc(Br)c2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL79031 470129 0 None None None Human 6.6 pIC50 = 6.6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 394 3 1 4 3.3 Cc1noc(NS(=O)(=O)c2cccc(Br)c2)c1Br 10.1016/0960-894X(96)00441-6
18617374 470351 0 None None None Human 6.6 pIC50 = 6.6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 350 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2cccc(Cl)c2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL80808 470351 0 None None None Human 6.6 pIC50 = 6.6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 350 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2cccc(Cl)c2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL262782 486064 0 None None None Mouse 6.6 pIC50 = 6.6 Binding
Binding affinity for Endothelin A receptor was determined in murine 3T3 cellsBinding affinity for Endothelin A receptor was determined in murine 3T3 cells
ChEMBL 848 25 10 9 1.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCNC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(00)80326-1
122044 24472 43 None None None Rat 6.6 pIC50 = 6.6 Binding
In vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptorIn vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptor
ChEMBL 473 9 2 8 3.7 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)c1 10.1021/jm0102304
CHEMBL115951 24472 43 None None None Rat 6.6 pIC50 = 6.6 Binding
In vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptorIn vitro for specific binding of [125I]ET1 to A10 cell expressed in endothelin A receptor
ChEMBL 473 9 2 8 3.7 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCO)c1 10.1021/jm0102304
44327728 474759 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 505 5 1 8 2.1 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(Br)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL96662 474759 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 505 5 1 8 2.1 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(Br)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
44327354 474907 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 427 5 1 8 1.4 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccccc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL97595 474907 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 427 5 1 8 1.4 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccccc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
10579210 333259 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 585 10 4 6 5.4 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCc3ccccc32)nc1C(=O)O 10.1021/jm950592+
CHEMBL435901 333259 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 585 10 4 6 5.4 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCc3ccccc32)nc1C(=O)O 10.1021/jm950592+
CHEMBL1791007 484822 0 None None None Pig 6.6 pIC50 = 6.6 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 610 7 6 6 0.8 CC[C@@H](C)[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL423941 488442 0 None None None Mouse 6.6 pIC50 = 6.6 Binding
The compound was tested for the binding affinity against eEndothelin A receptor in murine 3T3 cells using [125I]ET1 as a radioligandThe compound was tested for the binding affinity against eEndothelin A receptor in murine 3T3 cells using [125I]ET1 as a radioligand
ChEMBL 848 25 10 9 1.3 CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
21462925 238638 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 470 6 2 7 4.8 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2cc(N)ccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL349556 238638 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 470 6 2 7 4.8 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2cc(N)ccc23)cc1 10.1016/s0960-894x(99)00040-2
10766396 220104 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 460 8 1 4 4.6 CCCN(C)C(=O)CN1C[C@H](c2ccc3ccccc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL325418 220104 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 460 8 1 4 4.6 CCCN(C)C(=O)CN1C[C@H](c2ccc3ccccc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
10837666 334453 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 460 8 1 4 4.6 CCCN(C)C(=O)CN1C[C@H](c2cccc3ccccc23)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL444061 334453 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 460 8 1 4 4.6 CCCN(C)C(=O)CN1C[C@H](c2cccc3ccccc23)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
44284290 27209 0 None None None Pig 5.6 pIC50 = 5.6 Binding
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL 589 13 4 5 3.9 CC(C)C[C@@H](NC(=O)C1CCCCC1)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccn1)C(=O)O 10.1021/jm00087a001
CHEMBL1189291 27209 0 None None None Pig 5.6 pIC50 = 5.6 Binding
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL 589 13 4 5 3.9 CC(C)C[C@@H](NC(=O)C1CCCCC1)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccn1)C(=O)O 10.1021/jm00087a001
44320782 216720 0 None None None Rat 5.6 pIC50 = 5.6 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 482 7 1 6 5.8 COc1ccc(-c2nn(CC3CCCCC3)c(C(=O)O)c2Cc2cc3c(cc2Cl)OCO3)cc1 10.1016/s0960-894x(00)00513-8
CHEMBL315788 216720 0 None None None Rat 5.6 pIC50 = 5.6 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 482 7 1 6 5.8 COc1ccc(-c2nn(CC3CCCCC3)c(C(=O)O)c2Cc2cc3c(cc2Cl)OCO3)cc1 10.1016/s0960-894x(00)00513-8
44266629 18767 0 None None None Human 5.6 pIC50 = 5.6 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 387 4 1 5 4.7 COc1ccc(-n2c(C(=O)O)c(-c3ccc4c(c3)OCO4)c3ccccc32)cc1 10.1016/0960-894X(96)00170-9
CHEMBL10151 18767 0 None None None Human 5.6 pIC50 = 5.6 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 387 4 1 5 4.7 COc1ccc(-n2c(C(=O)O)c(-c3ccc4c(c3)OCO4)c3ccccc32)cc1 10.1016/0960-894X(96)00170-9
CHEMBL2304017 485319 0 None None None Pig 4.6 pIC50 = 4.6 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 667 7 6 8 0.8 CSC(C)(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(C#N)[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC1=O 10.1021/jm9600914
44278270 317541 0 None None None Human 4.6 pIC50 = 4.6 Binding
Compound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptorCompound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptor
ChEMBL 300 4 1 4 4.3 COc1cccc(Sc2c(C(=O)O)oc3ccccc23)c1 10.1016/0960-894X(96)00232-6
CHEMBL416019 317541 0 None None None Human 4.6 pIC50 = 4.6 Binding
Compound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptorCompound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptor
ChEMBL 300 4 1 4 4.3 COc1cccc(Sc2c(C(=O)O)oc3ccccc23)c1 10.1016/0960-894X(96)00232-6
23445430 123827 0 None None None Human 6.6 pIC50 = 6.6 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 438 5 1 5 5.1 Cc1ccc(/C=C/c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00133-9
CHEMBL176422 123827 0 None None None Human 6.6 pIC50 = 6.6 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 438 5 1 5 5.1 Cc1ccc(/C=C/c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00133-9
10530424 124840 0 None None None Rat 4.6 pIC50 = 4.6 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 536 9 4 5 4.3 Cc1c(C(=O)O)nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)n1C 10.1021/jm950592+
CHEMBL177502 124840 0 None None None Rat 4.6 pIC50 = 4.6 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 536 9 4 5 4.3 Cc1c(C(=O)O)nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)n1C 10.1021/jm950592+
23445438 124257 0 None None None Human 6.6 pIC50 = 6.6 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 470 6 1 7 4.1 Cc1noc(NS(=O)(=O)c2sccc2CCc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
CHEMBL177070 124257 0 None None None Human 6.6 pIC50 = 6.6 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 470 6 1 7 4.1 Cc1noc(NS(=O)(=O)c2sccc2CCc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
44384826 122752 0 None None None Human 6.6 pIC50 = 6.6 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 561 10 1 9 5.8 C/C=C/COc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL173366 122752 0 None None None Human 6.6 pIC50 = 6.6 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 561 10 1 9 5.8 C/C=C/COc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
9896251 199018 0 None None None Human 7.6 pIC50 = 7.6 Binding
Compound was evaluated for inhibitory activity against human Endothelin A receptor (ETA)Compound was evaluated for inhibitory activity against human Endothelin A receptor (ETA)
ChEMBL 682 12 1 9 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1021/jm020138n
CHEMBL278176 199018 0 None None None Human 7.6 pIC50 = 7.6 Binding
Compound was evaluated for inhibitory activity against human Endothelin A receptor (ETA)Compound was evaluated for inhibitory activity against human Endothelin A receptor (ETA)
ChEMBL 682 12 1 9 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1021/jm020138n
127034758 273816 0 None None None Human 7.6 pIC50 = 7.6 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 681 12 1 8 7.7 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)cc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1039/C4MD00499J
CHEMBL3734968 273816 0 None None None Human 7.6 pIC50 = 7.6 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 681 12 1 8 7.7 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)cc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1039/C4MD00499J
10576379 201401 0 None None None Human 7.6 pIC50 = 7.6 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 471 6 2 7 3.9 COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9608366
CHEMBL296291 201401 0 None None None Human 7.6 pIC50 = 7.6 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 471 6 2 7 3.9 COc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9608366
10281192 123838 0 None None None Human 7.6 pIC50 = 7.6 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 561 11 2 10 4.2 C#CCOc1nc(-c2ccnc(CO)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL176482 123838 0 None None None Human 7.6 pIC50 = 7.6 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 561 11 2 10 4.2 C#CCOc1nc(-c2ccnc(CO)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
9896251 199018 0 None None None Human 7.6 pIC50 = 7.6 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 682 12 1 9 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL278176 199018 0 None None None Human 7.6 pIC50 = 7.6 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 682 12 1 9 7.1 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
44404967 272856 0 None None None Human 7.6 pIC50 = 7.6 Binding
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 680 12 1 8 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 10.1021/jm058225d
CHEMBL372814 272856 0 None None None Human 7.6 pIC50 = 7.6 Binding
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 680 12 1 8 7.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCC2 10.1021/jm058225d
CHEMBL343582 487093 0 None None None Pig 7.6 pIC50 = 7.6 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 644 7 6 6 1.5 CC(C)C[C@H]1NC(=O)[C@H](c2ccccc2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
42630654 42264 0 None None None Human 7.6 pIC50 = 7.6 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 545 10 2 8 4.3 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCOC)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL1271531 42264 0 None None None Human 7.6 pIC50 = 7.6 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 545 10 2 8 4.3 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCOC)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
42630654 42264 0 None None None Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 545 10 2 8 4.3 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCOC)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1271531 42264 0 None None None Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 545 10 2 8 4.3 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCOC)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
11763363 220038 0 None None None Pig 7.6 pIC50 = 7.6 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 11 1 10 4.6 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2cnccn2)c1 10.1021/jm0102304
CHEMBL324943 220038 0 None None None Pig 7.6 pIC50 = 7.6 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 11 1 10 4.6 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2cnccn2)c1 10.1021/jm0102304
101039204 1466 45 None None None Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/j.bmcl.2010.08.074
443289 1466 45 None None None Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/j.bmcl.2010.08.074
997 1466 45 None None None Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/j.bmcl.2010.08.074
CHEMBL314691 1466 45 None None None Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/j.bmcl.2010.08.074
CHEMBL4095638 1466 45 None None None Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/j.bmcl.2010.08.074
DB12054 1466 45 None None None Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/j.bmcl.2010.08.074
10915215 200947 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 354 4 1 5 3.8 CC(C)Oc1ccc2c(c1)C=C(C(=O)O)[C@@H](c1ccc3c(c1)OCO3)O2 10.1021/jm031041j
CHEMBL293161 200947 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 354 4 1 5 3.8 CC(C)Oc1ccc2c(c1)C=C(C(=O)O)[C@@H](c1ccc3c(c1)OCO3)O2 10.1021/jm031041j
18617389 328451 0 None None None Human 6.6 pIC50 = 6.6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 408 3 1 4 3.6 Cc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL420029 328451 0 None None None Human 6.6 pIC50 = 6.6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 408 3 1 4 3.6 Cc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
10646375 197379 0 None None None Human 6.6 pIC50 = 6.6 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 7 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3cc(OC)ccc3OC)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL267096 197379 0 None None None Human 6.6 pIC50 = 6.6 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 7 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3cc(OC)ccc3OC)=C2Cc2ccccc2)cc1 10.1021/jm9606507
10915215 200947 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 354 4 1 5 3.8 CC(C)Oc1ccc2c(c1)C=C(C(=O)O)[C@@H](c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL293161 200947 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 354 4 1 5 3.8 CC(C)Oc1ccc2c(c1)C=C(C(=O)O)[C@@H](c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
44327727 332917 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 503 6 1 8 3.0 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(-c3ccccc3)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL433373 332917 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 503 6 1 8 3.0 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(-c3ccccc3)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
44266640 198410 0 None None None Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 459 4 1 8 4.2 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc3c(cc2n1Cc1ccc2c(c1)OCO2)OCO3 10.1016/0960-894X(96)00170-9
CHEMBL273529 198410 0 None None None Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 459 4 1 8 4.2 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc3c(cc2n1Cc1ccc2c(c1)OCO2)OCO3 10.1016/0960-894X(96)00170-9
CHEMBL335780 486957 0 None None None Pig 6.6 pIC50 = 6.6 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 650 9 8 7 0.3 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL343768 487094 0 None None None Pig 6.6 pIC50 = 6.6 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 616 8 8 7 0.3 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CS)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10448516 199431 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3cc(N)ccc23)c1C 10.1021/jm00008a013
CHEMBL281511 199431 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3cc(N)ccc23)c1C 10.1021/jm00008a013
CHEMBL413880 488307 0 None None None Human 5.6 pIC50 = 5.6 Binding
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptorBinding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor
ChEMBL 1125 28 13 11 3.6 NC(=O)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00084-7
44283270 202968 0 None None None Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL 580 12 5 5 3.8 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1021/jm9600914
44314579 202968 0 None None None Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL 580 12 5 5 3.8 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1021/jm9600914
CHEMBL306123 202968 0 None None None Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL 580 12 5 5 3.8 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1021/jm9600914
CHEMBL431124 202968 0 None None None Human 5.6 pIC50 = 5.6 Binding
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL 580 12 5 5 3.8 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1021/jm9600914
10618166 122629 0 None None None Rat 5.6 pIC50 = 5.6 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 355 7 1 6 4.0 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccco1 10.1021/jm990378b
CHEMBL172880 122629 0 None None None Rat 5.6 pIC50 = 5.6 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 355 7 1 6 4.0 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccco1 10.1021/jm990378b
10151203 200944 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 429 5 1 6 4.2 COc1ccc(Cn2c(=O)c(C(=O)O)c(-c3ccc4c(c3)OCO4)c3ccccc32)cc1 10.1016/S0960-894X(97)00319-3
CHEMBL293151 200944 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 429 5 1 6 4.2 COc1ccc(Cn2c(=O)c(C(=O)O)c(-c3ccc4c(c3)OCO4)c3ccccc32)cc1 10.1016/S0960-894X(97)00319-3
10448516 199431 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3cc(N)ccc23)c1C 10.1021/jm00004a012
CHEMBL281511 199431 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3cc(N)ccc23)c1C 10.1021/jm00004a012
44266568 198393 0 None None None Human 5.6 pIC50 = 5.6 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 493 7 1 6 6.3 COc1ccc(-c2c(C(=O)O)n(-c3ccc4c(c3)OCO4)c3ccc(OCc4ccccc4)cc23)cc1 10.1016/0960-894X(96)00170-9
CHEMBL273410 198393 0 None None None Human 5.6 pIC50 = 5.6 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 493 7 1 6 6.3 COc1ccc(-c2c(C(=O)O)n(-c3ccc4c(c3)OCO4)c3ccc(OCc4ccccc4)cc23)cc1 10.1016/0960-894X(96)00170-9
10313743 195912 0 None None None Rat 4.6 pIC50 = 4.6 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3c(N)cccc3c2)c1C 10.1021/jm00008a013
CHEMBL25756 195912 0 None None None Rat 4.6 pIC50 = 4.6 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3c(N)cccc3c2)c1C 10.1021/jm00008a013
10314989 200048 0 None None None Rat 4.6 pIC50 = 4.6 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 336 3 1 4 3.9 Cc1noc(NS(=O)(=O)c2cccc3c(Cl)cccc23)c1C 10.1021/jm00008a013
CHEMBL285814 200048 0 None None None Rat 4.6 pIC50 = 4.6 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 336 3 1 4 3.9 Cc1noc(NS(=O)(=O)c2cccc3c(Cl)cccc23)c1C 10.1021/jm00008a013
127035379 273944 0 None None None Human 4.6 pIC50 = 4.6 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 691 13 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3736248 273944 0 None None None Human 4.6 pIC50 = 4.6 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 691 13 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
10507191 256726 0 None None None Rat 4.6 pIC50 = 4.6 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 565 10 4 5 5.6 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C2CC2)s1 10.1021/jm950591h
CHEMBL366911 256726 0 None None None Rat 4.6 pIC50 = 4.6 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 565 10 4 5 5.6 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C2CC2)s1 10.1021/jm950591h
CHEMBL2369710 485456 0 None None None Human 4.6 pIC50 = 4.6 Binding
Inhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cellsInhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cells
ChEMBL 830 21 8 8 1.4 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00152-J
10313743 195912 0 None None None Rat 4.6 pIC50 = 4.6 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3c(N)cccc3c2)c1C 10.1021/jm00004a012
CHEMBL25756 195912 0 None None None Rat 4.6 pIC50 = 4.6 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3c(N)cccc3c2)c1C 10.1021/jm00004a012
10813822 197294 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 460 5 2 5 4.5 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)Nc2ccccc2)cc1 10.1021/jm9505369
CHEMBL266336 197294 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 460 5 2 5 4.5 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)Nc2ccccc2)cc1 10.1021/jm9505369
9915028 23715 19 None None None Human 4.6 pIC50 = 4.6 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
CHEMBL111612 23715 19 None None None Human 4.6 pIC50 = 4.6 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]ET1 from chinese hamster ovary cells(CHO)
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
10218058 163098 0 None None None Human 7.6 pIC50 = 7.6 Binding
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 523 12 2 10 3.1 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL2163695 163098 0 None None None Human 7.6 pIC50 = 7.6 Binding
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 523 12 2 10 3.1 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL97470 489426 0 None None None Human 7.6 pIC50 = 7.6 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 939 26 10 9 3.0 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10600668 19497 0 None None None Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 476 7 1 8 3.8 COc1cc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc(OC)c1OC 10.1021/jm9606507
CHEMBL10589 19497 0 None None None Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 476 7 1 8 3.8 COc1cc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc(OC)c1OC 10.1021/jm9606507
10625269 38369 0 None None None Human 7.6 pIC50 = 7.6 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2ccc(C)cc2C)cc1 10.1021/jm990170q
CHEMBL120106 38369 0 None None None Human 7.6 pIC50 = 7.6 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2ccc(C)cc2C)cc1 10.1021/jm990170q
10792783 123143 0 None None None Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 551 10 3 6 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N(C)C2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL174699 123143 0 None None None Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 551 10 3 6 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N(C)C2CCCCC2)nc1C(=O)O 10.1021/jm9505932
10218058 163098 0 None None None Human 7.6 pIC50 = 7.6 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 523 12 2 10 3.1 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCO 10.1021/jm3009103
CHEMBL2163695 163098 0 None None None Human 7.6 pIC50 = 7.6 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 523 12 2 10 3.1 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCO 10.1021/jm3009103
10951918 220391 0 None None None Pig 7.6 pIC50 = 7.6 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 567 11 1 10 5.3 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2SCCOc2ncccn2)c1 10.1021/jm0102304
CHEMBL326105 220391 0 None None None Pig 7.6 pIC50 = 7.6 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 567 11 1 10 5.3 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2SCCOc2ncccn2)c1 10.1021/jm0102304
44327656 278985 0 None None None Human 6.6 pIC50 = 6.6 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 977 25 9 8 4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(F)(F)F)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL386181 278985 0 None None None Human 6.6 pIC50 = 6.6 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 977 25 9 8 4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(F)(F)F)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL21253 485132 0 None None None Mouse 6.6 pIC50 = 6.6 Binding
Binding affinity for Endothelin A receptor was determined in murine 3T3 cellsBinding affinity for Endothelin A receptor was determined in murine 3T3 cells
ChEMBL 848 25 10 9 1.3 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](N)CCCNC(=O)[C@H](Cc1ccccc1)NC(C)=O)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/S0960-894X(00)80326-1
10862228 468019 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 398 7 1 6 4.2 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC)cc21 10.1021/jm010382z
CHEMBL63000 468019 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 398 7 1 6 4.2 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC)cc21 10.1021/jm010382z
CHEMBL405677 487876 0 None None None Human 6.6 pIC50 = 6.6 Binding
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptorBinding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor
ChEMBL 1123 28 12 11 4.1 CC(=O)[C@@H](Cc1c[nH]c2ccccc12)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00084-7
44266552 18860 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 10.1016/s0960-894x(97)10151-2
CHEMBL10218 18860 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 10.1016/s0960-894x(97)10151-2
56671734 126038 0 None None None Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 9 3.6 CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)NCC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@@H](C)CC 10.1021/jm970161m
CHEMBL1793932 126038 0 None None None Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 9 3.6 CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)NCC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@@H](C)CC 10.1021/jm970161m
44266552 18860 0 None None None Human 6.6 pIC50 = 6.6 Binding
Potency at Endothelin A receptor was determinedPotency at Endothelin A receptor was determined
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 10.1021/jm0300429
CHEMBL10218 18860 0 None None None Human 6.6 pIC50 = 6.6 Binding
Potency at Endothelin A receptor was determinedPotency at Endothelin A receptor was determined
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 10.1021/jm0300429
CHEMBL341443 487033 0 None None None Pig 6.6 pIC50 = 6.6 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 627 10 8 7 0.1 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](CCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44368824 197153 0 None None None Human 5.6 pIC50 = 5.6 Binding
Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)
ChEMBL 1595 31 19 20 0.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
77282142 197153 0 None None None Human 5.6 pIC50 = 5.6 Binding
Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)
ChEMBL 1595 31 19 20 0.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
CHEMBL265164 197153 0 None None None Human 5.6 pIC50 = 5.6 Binding
Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)
ChEMBL 1595 31 19 20 0.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
CHEMBL412460 488220 0 None None None Human 5.6 pIC50 = 5.6 Binding
Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)
ChEMBL 1670 33 22 23 -2.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
18617363 329492 0 None None None Human 5.6 pIC50 = 5.6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 384 3 1 4 3.9 Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL421523 329492 0 None None None Human 5.6 pIC50 = 5.6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 384 3 1 4 3.9 Cc1noc(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL37860 487579 0 None None None Pig 5.6 pIC50 = 5.6 Binding
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL 604 12 4 5 3.7 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccn1)C(=O)O 10.1021/jm00087a001
44368905 317340 0 None None None Rat 5.6 pIC50 = 5.6 Binding
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1623 31 19 20 1.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
77282145 317340 0 None None None Rat 5.6 pIC50 = 5.6 Binding
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1623 31 19 20 1.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
CHEMBL414448 317340 0 None None None Rat 5.6 pIC50 = 5.6 Binding
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1623 31 19 20 1.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCCCCCCC(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
10792784 122372 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 551 10 4 5 5.4 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C(C)C)o1 10.1021/jm950591h
CHEMBL171910 122372 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 551 10 4 5 5.4 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C(C)C)o1 10.1021/jm950591h
44309488 468965 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 471 7 1 8 5.1 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2nonc2c1 10.1016/s0960-894x(97)10151-2
CHEMBL69664 468965 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 471 7 1 8 5.1 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2nonc2c1 10.1016/s0960-894x(97)10151-2
44327726 474756 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 495 6 1 8 2.7 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)n2nc3c(cc2=O)CCC3)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL96644 474756 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 495 6 1 8 2.7 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)n2nc3c(cc2=O)CCC3)cc1 10.1016/S0960-894X(96)00617-8
44309488 468965 0 None None None Human 5.6 pIC50 = 5.6 Binding
Potency at Endothelin A receptor was determinedPotency at Endothelin A receptor was determined
ChEMBL 471 7 1 8 5.1 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2nonc2c1 10.1021/jm0300429
CHEMBL69664 468965 0 None None None Human 5.6 pIC50 = 5.6 Binding
Potency at Endothelin A receptor was determinedPotency at Endothelin A receptor was determined
ChEMBL 471 7 1 8 5.1 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2nonc2c1 10.1021/jm0300429
10038537 122749 0 None None None Human 5.6 pIC50 = 5.6 Binding
Tested for binding affinity towards human Endothelin A receptorTested for binding affinity towards human Endothelin A receptor
ChEMBL 266 3 2 5 0.8 C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(O)[C@]2(O)CC1 10.1016/s0960-894x(00)00136-0
CHEMBL173336 122749 0 None None None Human 5.6 pIC50 = 5.6 Binding
Tested for binding affinity towards human Endothelin A receptorTested for binding affinity towards human Endothelin A receptor
ChEMBL 266 3 2 5 0.8 C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(O)[C@]2(O)CC1 10.1016/s0960-894x(00)00136-0
44279479 199500 1 None None None Pig 4.6 pIC50 = 4.6 Binding
Binding affinity against ETA receptor in porcine aortic smooth muscle membrane was determinedBinding affinity against ETA receptor in porcine aortic smooth muscle membrane was determined
ChEMBL 516 14 6 5 1.8 CC(C)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(=O)O)C(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL281963 199500 1 None None None Pig 4.6 pIC50 = 4.6 Binding
Binding affinity against ETA receptor in porcine aortic smooth muscle membrane was determinedBinding affinity against ETA receptor in porcine aortic smooth muscle membrane was determined
ChEMBL 516 14 6 5 1.8 CC(C)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(=O)O)C(=O)O 10.1016/0960-894X(95)00221-E
44279439 217002 0 None None None Human 4.6 pIC50 = 4.6 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 534 3 2 3 6.2 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccc(C(F)(F)F)cc3C(F)(F)F)cc21 10.1016/0960-894X(95)00230-Q
CHEMBL31781 217002 0 None None None Human 4.6 pIC50 = 4.6 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 534 3 2 3 6.2 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccc(C(F)(F)F)cc3C(F)(F)F)cc21 10.1016/0960-894X(95)00230-Q
CHEMBL137569 484667 0 None None None Pig 4.6 pIC50 = 4.6 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 638 9 6 6 1.6 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10787482 197285 0 None None None Human 6.6 pIC50 = 6.6 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 405 4 1 4 3.9 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Br)nc3)cccc12 10.1021/jm9604585
CHEMBL266277 197285 0 None None None Human 6.6 pIC50 = 6.6 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 405 4 1 4 3.9 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Br)nc3)cccc12 10.1021/jm9604585
10740139 468013 0 None None None Human 6.6 pIC50 = 6.6 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 406 4 1 5 3.3 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Br)nn3)cccc12 10.1021/jm9604585
CHEMBL6297 468013 0 None None None Human 6.6 pIC50 = 6.6 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 406 4 1 5 3.3 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Br)nn3)cccc12 10.1021/jm9604585
18617288 470008 0 None None None Human 5.6 pIC50 = 5.6 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 316 3 1 4 2.5 Cc1noc(NS(=O)(=O)c2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL78080 470008 0 None None None Human 5.6 pIC50 = 5.6 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 316 3 1 4 2.5 Cc1noc(NS(=O)(=O)c2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
10646522 468410 0 None None None Human 5.6 pIC50 = 5.6 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 434 5 1 5 3.8 CCc1nc(Br)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
CHEMBL6543 468410 0 None None None Human 5.6 pIC50 = 5.6 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 434 5 1 5 3.8 CCc1nc(Br)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
22998439 468142 0 None None None Human 5.6 pIC50 = 5.6 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 392 5 1 7 3.7 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/S0960-894X(97)00367-3
CHEMBL63938 468142 0 None None None Human 5.6 pIC50 = 5.6 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 392 5 1 7 3.7 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/S0960-894X(97)00367-3
10650368 123135 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 553 10 5 7 3.6 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCC(O)CC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL174635 123135 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 553 10 5 7 3.6 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCC(O)CC2)nc1C(=O)O 10.1021/jm950592+
10789715 222554 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 450 8 1 5 4.2 CCCN(C)C(=O)CN1C[C@H](c2cccc3occc23)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL331375 222554 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 450 8 1 5 4.2 CCCN(C)C(=O)CN1C[C@H](c2cccc3occc23)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
10575552 220817 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 450 8 1 5 4.2 CCCN(C)C(=O)CN1C[C@H](c2ccc3ccoc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL326690 220817 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 450 8 1 5 4.2 CCCN(C)C(=O)CN1C[C@H](c2ccc3ccoc3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
9871561 348836 0 None None None Human 7.6 pIC50 = 7.6 Binding
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 527 10 2 8 4.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cc2)nc(C(F)(F)F)nc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL4562189 348836 0 None None None Human 7.6 pIC50 = 7.6 Binding
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 527 10 2 8 4.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cc2)nc(C(F)(F)F)nc1OCCO 10.1016/j.bmcl.2016.06.014
44314657 203251 0 None None None Pig 7.6 pIC50 = 7.6 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 619 13 5 4 4.3 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCC1)C(=O)O 10.1021/jm9600914
CHEMBL308383 203251 0 None None None Pig 7.6 pIC50 = 7.6 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 619 13 5 4 4.3 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCC1)C(=O)O 10.1021/jm9600914
10288020 38535 0 None None None Rat 7.6 pIC50 = 7.6 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 430 7 1 6 4.7 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1205067 38535 0 None None None Rat 7.6 pIC50 = 7.6 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 430 7 1 6 4.7 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
11796594 474276 0 None None None Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 424 10 1 5 5.8 CC(=O)c1ccc(OCc2ccsc2)cc1OC(CCC(=O)O)c1ccccc1C 10.1021/jm9707131
CHEMBL93776 474276 0 None None None Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 424 10 1 5 5.8 CC(=O)c1ccc(OCc2ccsc2)cc1OC(CCC(=O)O)c1ccccc1C 10.1021/jm9707131
10144334 258561 0 None None None Human 7.6 pIC50 = 7.6 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 561 10 2 10 4.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL368211 258561 0 None None None Human 7.6 pIC50 = 7.6 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 561 10 2 10 4.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL147510 484694 0 None None None Mouse 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL 864 25 11 10 1.0 CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
44385941 258572 0 None None None Rat 7.6 pIC50 = 7.6 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 550 10 5 5 4.6 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCC(C)C2)nc1C(=O)O 10.1021/jm950592+
CHEMBL368286 258572 0 None None None Rat 7.6 pIC50 = 7.6 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 550 10 5 5 4.6 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCC(C)C2)nc1C(=O)O 10.1021/jm950592+
31771 197290 38 None None None Rat 6.6 pIC50 = 6.6 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 267 3 2 5 1.7 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00008a013
CHEMBL26630 197290 38 None None None Rat 6.6 pIC50 = 6.6 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 267 3 2 5 1.7 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00008a013
11755275 444728 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 489 9 1 7 4.8 CCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)c(=O)n2Cc1cc(OC)ccc1OC 10.1016/S0960-894X(97)00319-3
CHEMBL59537 444728 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 489 9 1 7 4.8 CCOc1ccc2c(c1)c(-c1ccc(OC)cc1)c(C(=O)O)c(=O)n2Cc1cc(OC)ccc1OC 10.1016/S0960-894X(97)00319-3
31771 197290 38 None None None Rat 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 267 3 2 5 1.7 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00004a012
CHEMBL26630 197290 38 None None None Rat 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 267 3 2 5 1.7 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00004a012
56657875 126034 0 None None None Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 9 3.6 CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@@H](C)CC 10.1021/jm970161m
CHEMBL1793925 126034 0 None None None Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 9 3.6 CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@@H](C)CC 10.1021/jm970161m
56681798 126037 0 None None None Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 9 3.6 CC[C@@H](C)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)CNC(=O)[C@H](NC(=O)[C@H](N)Cc1c[nH]c2ccccc12)[C@H](C)CC 10.1021/jm970161m
CHEMBL1793929 126037 0 None None None Human 6.6 pIC50 = 6.6 Binding
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 9 3.6 CC[C@@H](C)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)CNC(=O)[C@H](NC(=O)[C@H](N)Cc1c[nH]c2ccccc12)[C@H](C)CC 10.1021/jm970161m
44327252 474421 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 495 7 1 8 3.1 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)n2nc(C3CC3)ccc2=O)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL94654 474421 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 495 7 1 8 3.1 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)n2nc(C3CC3)ccc2=O)cc1 10.1016/S0960-894X(96)00617-8
44266592 19711 0 None None None Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 431 4 1 7 4.5 COc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2-c1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL10699 19711 0 None None None Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 431 4 1 7 4.5 COc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2-c1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL137754 484671 0 None None None Pig 6.6 pIC50 = 6.6 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 582 6 6 6 0.2 CC(C)C[C@H]1NC(=O)[C@H](C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
CHEMBL436884 488638 0 None None None Human 5.6 pIC50 = 5.6 Binding
Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)
ChEMBL 1409 30 16 17 1.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
44328019 311639 0 None None None Human 5.6 pIC50 = 5.6 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 1000 26 9 8 5.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL405178 311639 0 None None None Human 5.6 pIC50 = 5.6 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 1000 26 9 8 5.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
44327348 317416 0 None None None Human 5.6 pIC50 = 5.6 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 1076 28 9 8 7.0 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL415238 317416 0 None None None Human 5.6 pIC50 = 5.6 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 1076 28 9 8 7.0 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10216862 393216 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 443 4 1 7 3.9 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n(Cc2ccc3c(c2)OCO3)c1=O 10.1016/S0960-894X(97)00319-3
CHEMBL56286 393216 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 443 4 1 7 3.9 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n(Cc2ccc3c(c2)OCO3)c1=O 10.1016/S0960-894X(97)00319-3
44327412 474466 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 497 5 1 8 3.0 Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL94929 474466 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 497 5 1 8 3.0 Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
44327114 474678 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 533 7 1 7 4.1 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)N2N=C(c3ccccc3)CCC2=O)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL96234 474678 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 533 7 1 7 4.1 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)N2N=C(c3ccccc3)CCC2=O)cc1 10.1016/S0960-894X(96)00617-8
10244529 122063 0 None None None Human 5.6 pIC50 = 5.6 Binding
Tested for binding affinity towards human Endothelin A receptorTested for binding affinity towards human Endothelin A receptor
ChEMBL 264 3 1 5 1.0 C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(=O)[C@]2(O)CC1 10.1016/s0960-894x(00)00136-0
CHEMBL170450 122063 0 None None None Human 5.6 pIC50 = 5.6 Binding
Tested for binding affinity towards human Endothelin A receptorTested for binding affinity towards human Endothelin A receptor
ChEMBL 264 3 1 5 1.0 C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(=O)[C@]2(O)CC1 10.1016/s0960-894x(00)00136-0
44279371 200105 0 None None None Human 4.6 pIC50 = 4.6 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 466 3 2 3 5.5 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3cc(Cl)cc(Cl)c3)cc21 10.1016/0960-894X(95)00230-Q
CHEMBL286214 200105 0 None None None Human 4.6 pIC50 = 4.6 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 466 3 2 3 5.5 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3cc(Cl)cc(Cl)c3)cc21 10.1016/0960-894X(95)00230-Q
6426756 297365 30 None None None Human 4.6 pIC50 = 4.6 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 537 9 3 10 3.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2nc(-c3ncccn3)nc(OCCO)c2Oc2ccccc2O)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL3956076 297365 30 None None None Human 4.6 pIC50 = 4.6 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 537 9 3 10 3.9 CC(C)(C)c1ccc(S(=O)(=O)Nc2nc(-c3ncccn3)nc(OCCO)c2Oc2ccccc2O)cc1 10.1016/j.bmcl.2016.06.014
23445254 474071 0 None None None Human 5.6 pIC50 = 5.6 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 412 5 1 5 4.2 Cc1noc(NS(=O)(=O)c2sccc2Cc2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL92318 474071 0 None None None Human 5.6 pIC50 = 5.6 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 412 5 1 5 4.2 Cc1noc(NS(=O)(=O)c2sccc2Cc2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
9810571 124146 0 None None None Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 731 18 2 13 5.0 CCCS(=O)(=O)NCCOc1nc(-c2cc(OC)c(OC)c(OC)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL176997 124146 0 None None None Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 731 18 2 13 5.0 CCCS(=O)(=O)NCCOc1nc(-c2cc(OC)c(OC)c(OC)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
127034756 273800 0 None None None Human 6.6 pIC50 = 6.6 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 679 12 2 7 7.5 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3734829 273800 0 None None None Human 6.6 pIC50 = 6.6 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 679 12 2 7 7.5 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3F)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
176 823 54 None None None Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2157 823 54 None None None Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2566 823 54 None None None Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
CHEMBL633 823 54 None None None Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
DB01118 823 54 None None None Human 4.6 pIC50 = 4.6 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
18617393 470133 0 None None None Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 308 5 1 4 3.2 CCc1ccc(CC)c(S(=O)(=O)Nc2onc(C)c2C)c1 10.1016/0960-894X(96)00441-6
CHEMBL79066 470133 0 None None None Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 308 5 1 4 3.2 CCc1ccc(CC)c(S(=O)(=O)Nc2onc(C)c2C)c1 10.1016/0960-894X(96)00441-6
44314647 469949 0 None None None Pig 7.6 pIC50 = 7.6 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 647 13 5 4 5.1 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCCCC1)C(=O)O 10.1021/jm9600914
CHEMBL77468 469949 0 None None None Pig 7.6 pIC50 = 7.6 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 647 13 5 4 5.1 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCCCC1)C(=O)O 10.1021/jm9600914
CHEMBL2304016 485318 0 None None None Pig 7.6 pIC50 = 7.6 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 644 5 6 6 1.5 CC(C)[C@H]1NC(=O)[C@H](C(C)(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Cl)[nH]c3ccccc23)NC1=O 10.1021/jm9600914
10502226 201651 0 None None None Human 7.6 pIC50 = 7.6 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 420 6 1 8 3.3 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1C 10.1021/jm9700068
CHEMBL298203 201651 0 None None None Human 7.6 pIC50 = 7.6 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 420 6 1 8 3.3 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Cc2ccc3c(c2)OCO3)c1C 10.1021/jm9700068
10715441 349901 0 None None None Human 7.6 pIC50 = 7.6 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 390 6 1 6 3.9 Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm9700068
CHEMBL45875 349901 0 None None None Human 7.6 pIC50 = 7.6 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 390 6 1 6 3.9 Cc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm9700068
10575755 353704 0 None None None Human 7.6 pIC50 = 7.6 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 2 6 4.2 Cc1ccccc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Br 10.1021/jm9608366
CHEMBL47450 353704 0 None None None Human 7.6 pIC50 = 7.6 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 2 6 4.2 Cc1ccccc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Br 10.1021/jm9608366
10168195 124147 0 None None None Human 7.6 pIC50 = 7.6 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 631 11 2 13 5.0 C#CCOc1nc(-c2ccnc(-c3noc(S)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL176999 124147 0 None None None Human 7.6 pIC50 = 7.6 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 631 11 2 13 5.0 C#CCOc1nc(-c2ccnc(-c3noc(S)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10744085 202925 0 None None None Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 503 9 1 8 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCN(C)C)c2)cc1 10.1021/jm980504w
CHEMBL305777 202925 0 None None None Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 503 9 1 8 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCN(C)C)c2)cc1 10.1021/jm980504w
10318748 199825 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 399 4 1 5 3.8 Cc1noc(NS(=O)(=O)c2cccc3c(N4CCCCC4=O)cccc23)c1C 10.1021/jm00008a013
CHEMBL284177 199825 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 399 4 1 5 3.8 Cc1noc(NS(=O)(=O)c2cccc3c(N4CCCCC4=O)cccc23)c1C 10.1021/jm00008a013
44316527 470321 0 None None None Human 6.6 pIC50 = 6.6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 280 3 1 4 2.7 Cc1ccc(C)c(S(=O)(=O)Nc2onc(C)c2C)c1 10.1016/0960-894X(96)00441-6
CHEMBL80532 470321 0 None None None Human 6.6 pIC50 = 6.6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 280 3 1 4 2.7 Cc1ccc(C)c(S(=O)(=O)Nc2onc(C)c2C)c1 10.1016/0960-894X(96)00441-6
44316831 470350 0 None None None Human 6.6 pIC50 = 6.6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 358 4 1 4 3.4 CCc1ccc(Br)c(S(=O)(=O)Nc2onc(C)c2C)c1 10.1016/0960-894X(96)00441-6
CHEMBL80807 470350 0 None None None Human 6.6 pIC50 = 6.6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 358 4 1 4 3.4 CCc1ccc(Br)c(S(=O)(=O)Nc2onc(C)c2C)c1 10.1016/0960-894X(96)00441-6
15296635 199754 0 None None None Pig 6.6 pIC50 = 6.6 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 488 11 5 5 2.7 CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL283591 199754 0 None None None Pig 6.6 pIC50 = 6.6 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 488 11 5 5 2.7 CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
23445224 468416 0 None None None Human 6.6 pIC50 = 6.6 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 406 5 1 7 4.0 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1016/S0960-894X(97)00367-3
CHEMBL65488 468416 0 None None None Human 6.6 pIC50 = 6.6 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 406 5 1 7 4.0 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1016/S0960-894X(97)00367-3
CHEMBL356864 487133 0 None None None Mouse 6.6 pIC50 = 6.6 Binding
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL 881 24 9 8 2.8 CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
CHEMBL1791006 484821 0 None None None Pig 6.6 pIC50 = 6.6 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 614 8 8 7 -0.3 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H]([C@H](C)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44371396 102759 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 471 6 1 6 5.9 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3SC)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL156532 102759 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 471 6 1 6 5.9 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3SC)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
44371532 104708 1 None None None Rat 5.6 pIC50 = 5.6 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 455 6 1 6 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cccc(OC)c3)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL158239 104708 1 None None None Rat 5.6 pIC50 = 5.6 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 455 6 1 6 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cccc(OC)c3)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
44371571 238240 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 425 5 1 5 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL345380 238240 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 425 5 1 5 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
10473627 201996 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2cc(S(=O)(=O)Nc3onc(C)c3C)ccc12 10.1021/jm00008a013
CHEMBL30077 201996 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2cc(S(=O)(=O)Nc3onc(C)c3C)ccc12 10.1021/jm00008a013
18617395 470128 0 None None None Human 5.6 pIC50 = 5.6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 361 4 1 6 2.5 Cc1noc(NS(=O)(=O)c2cccc([N+](=O)[O-])c2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL79030 470128 0 None None None Human 5.6 pIC50 = 5.6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 361 4 1 6 2.5 Cc1noc(NS(=O)(=O)c2cccc([N+](=O)[O-])c2)c1Br 10.1016/0960-894X(96)00441-6
10473627 201996 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2cc(S(=O)(=O)Nc3onc(C)c3C)ccc12 10.1021/jm00004a012
CHEMBL30077 201996 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2cc(S(=O)(=O)Nc3onc(C)c3C)ccc12 10.1021/jm00004a012
56681797 126033 0 None None None Human 5.6 pIC50 = 5.6 Binding
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 9 3.6 CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@H](C)CC 10.1021/jm970161m
CHEMBL1793924 126033 0 None None None Human 5.6 pIC50 = 5.6 Binding
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 9 3.6 CC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@H](C)CC 10.1021/jm970161m
44213924 474385 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 567 7 1 7 4.8 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)N2N=C(c3ccc(Cl)cc3)CCC2=O)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL94426 474385 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 567 7 1 7 4.8 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)N2N=C(c3ccc(Cl)cc3)CCC2=O)cc1 10.1016/S0960-894X(96)00617-8
44266537 18676 0 None None None Human 5.6 pIC50 = 5.6 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 507 8 1 6 6.4 COc1ccc(Cn2c(C(=O)O)c(-c3ccc4c(c3)OCO4)c3cc(OCc4ccccc4)ccc32)cc1 10.1016/0960-894X(96)00170-9
CHEMBL10092 18676 0 None None None Human 5.6 pIC50 = 5.6 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 507 8 1 6 6.4 COc1ccc(Cn2c(C(=O)O)c(-c3ccc4c(c3)OCO4)c3cc(OCc4ccccc4)ccc32)cc1 10.1016/0960-894X(96)00170-9
44368414 239893 0 None None None Pig 4.6 pIC50 = 4.6 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 459 9 1 5 4.2 COc1ccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2ccccc2)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
CHEMBL357978 239893 0 None None None Pig 4.6 pIC50 = 4.6 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 459 9 1 5 4.2 COc1ccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2ccccc2)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
10470588 200171 1 None None None Human 4.6 pIC50 = 4.6 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 309 6 2 5 2.9 CCCNc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm00029a001
CHEMBL286682 200171 1 None None None Human 4.6 pIC50 = 4.6 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 309 6 2 5 2.9 CCCNc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm00029a001
10470588 200171 1 None None None Rat 4.6 pIC50 = 4.6 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 309 6 2 5 2.9 CCCNc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm00008a013
CHEMBL286682 200171 1 None None None Rat 4.6 pIC50 = 4.6 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 309 6 2 5 2.9 CCCNc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm00008a013
127035068 273819 0 None None None Human 4.6 pIC50 = 4.6 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 633 10 2 7 7.7 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735036 273819 0 None None None Human 4.6 pIC50 = 4.6 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 633 10 2 7 7.7 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
10604119 25734 0 None None None Human 4.6 pIC50 = 4.6 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 636 12 2 7 5.8 COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 10.1021/jm990171i
CHEMBL1180361 25734 0 None None None Human 4.6 pIC50 = 4.6 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 636 12 2 7 5.8 COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2C)c2ccccc2C)cc1 10.1021/jm990171i
23445241 202708 0 None None None Human 5.6 pIC50 = 5.6 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 442 5 1 7 3.8 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccccc2)c1Br 10.1016/S0960-894X(97)00367-3
CHEMBL304406 202708 0 None None None Human 5.6 pIC50 = 5.6 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 442 5 1 7 3.8 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccccc2)c1Br 10.1016/S0960-894X(97)00367-3
10554724 124517 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCC(C)CC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL177195 124517 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCC(C)CC2)nc1C(=O)O 10.1021/jm950592+
12146375 197175 0 None None None Human 5.6 pIC50 = 5.6 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 322 3 1 5 2.6 Cc1noc(NS(=O)(=O)c2ccsc2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL265290 197175 0 None None None Human 5.6 pIC50 = 5.6 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 322 3 1 5 2.6 Cc1noc(NS(=O)(=O)c2ccsc2)c1Br 10.1016/S0960-894X(96)00496-9
9975719 196381 0 None None None Rat 4.6 pIC50 = 4.6 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2ccc(S(=O)(=O)Nc3onc(C)c3C)cc12 10.1021/jm00008a013
CHEMBL25977 196381 0 None None None Rat 4.6 pIC50 = 4.6 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2ccc(S(=O)(=O)Nc3onc(C)c3C)cc12 10.1021/jm00008a013
9975719 196381 0 None None None Rat 4.6 pIC50 = 4.6 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2ccc(S(=O)(=O)Nc3onc(C)c3C)cc12 10.1021/jm00004a012
CHEMBL25977 196381 0 None None None Rat 4.6 pIC50 = 4.6 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2ccc(S(=O)(=O)Nc3onc(C)c3C)cc12 10.1021/jm00004a012
127034919 273952 0 None None None Human 6.6 pIC50 = 6.6 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 599 10 2 7 6.6 CCCc1nc2c(C)cc(C(=O)NC(C)C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3736310 273952 0 None None None Human 6.6 pIC50 = 6.6 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 599 10 2 7 6.6 CCCc1nc2c(C)cc(C(=O)NC(C)C)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
44384610 256411 0 None None None Human 5.6 pIC50 = 5.6 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 743 16 2 14 4.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL366627 256411 0 None None None Human 5.6 pIC50 = 5.6 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 743 16 2 14 4.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
137633653 312518 0 None None None Human 6.6 pIC50 = 6.6 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 593 10 2 9 5.0 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC4CCC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4068786 312518 0 None None None Human 6.6 pIC50 = 6.6 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 593 10 2 9 5.0 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC4CCC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
9868822 22904 0 None None None Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 459 6 1 7 3.9 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(N(C)C)cc2)cc1 10.1021/jm9606507
CHEMBL10948 22904 0 None None None Human 7.6 pIC50 = 7.6 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 459 6 1 7 3.9 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(N(C)C)cc2)cc1 10.1021/jm9606507
CHEMBL2304013 485315 0 None None None Pig 7.6 pIC50 = 7.6 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 688 5 6 6 1.6 CC(C)[C@H]1NC(=O)[C@H](C(C)(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Br)[nH]c3ccccc23)NC1=O 10.1021/jm9600914
101039204 1466 45 None None None Rat 7.6 pIC50 = 7.6 Binding
Displacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hrDisplacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hr
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1007/s00044-013-0542-3
443289 1466 45 None None None Rat 7.6 pIC50 = 7.6 Binding
Displacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hrDisplacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hr
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1007/s00044-013-0542-3
997 1466 45 None None None Rat 7.6 pIC50 = 7.6 Binding
Displacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hrDisplacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hr
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1007/s00044-013-0542-3
CHEMBL314691 1466 45 None None None Rat 7.6 pIC50 = 7.6 Binding
Displacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hrDisplacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hr
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1007/s00044-013-0542-3
CHEMBL4095638 1466 45 None None None Rat 7.6 pIC50 = 7.6 Binding
Displacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hrDisplacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hr
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1007/s00044-013-0542-3
DB12054 1466 45 None None None Rat 7.6 pIC50 = 7.6 Binding
Displacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hrDisplacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hr
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1007/s00044-013-0542-3
CHEMBL336033 484275 0 None None None Rat 7.6 pIC50 = 7.6 Binding
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 610 7 6 6 0.8 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1016/j.bmc.2015.01.003
44295224 38537 0 None None None Rat 7.6 pIC50 = 7.6 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 532 9 1 9 4.6 COc1cc(C/C(C(=O)c2ccc3c(c2)CCO3)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
CHEMBL1205077 38537 0 None None None Rat 7.6 pIC50 = 7.6 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 532 9 1 9 4.6 COc1cc(C/C(C(=O)c2ccc3c(c2)CCO3)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
44294929 38695 0 None None None Rat 7.6 pIC50 = 7.6 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 460 8 1 7 4.7 COc1ccc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1206731 38695 0 None None None Rat 7.6 pIC50 = 7.6 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 460 8 1 7 4.7 COc1ccc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
44320375 216787 0 None None None Rat 7.6 pIC50 = 7.6 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 506 8 1 7 5.3 COc1cc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)cc(OC)c1 10.1016/s0960-894x(00)00513-8
CHEMBL316187 216787 0 None None None Rat 7.6 pIC50 = 7.6 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 506 8 1 7 5.3 COc1cc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)cc(OC)c1 10.1016/s0960-894x(00)00513-8
10252787 199480 0 None None None Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 442 7 1 6 4.6 COc1cccc(Cn2nc(-c3ccccc3)c(Cc3ccc4c(c3)OCO4)c2C(=O)O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL281865 199480 0 None None None Rat 7.6 pIC50 = 7.6 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 442 7 1 6 4.6 COc1cccc(Cn2nc(-c3ccccc3)c(Cc3ccc4c(c3)OCO4)c2C(=O)O)c1 10.1016/s0960-894x(00)00232-8
10839618 468579 0 None None None Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 517 10 1 8 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCCN(C)C)c2)cc1 10.1021/jm980504w
CHEMBL66762 468579 0 None None None Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 517 10 1 8 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCCN(C)C)c2)cc1 10.1021/jm980504w
17885919 473377 0 None None None Rat 7.6 pIC50 = 7.6 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 526 9 2 8 4.8 O=C(O)COc1ccccc1Cn1nc(-c2cccs2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O 10.1016/s0960-894x(00)00513-8
CHEMBL87801 473377 0 None None None Rat 7.6 pIC50 = 7.6 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 526 9 2 8 4.8 O=C(O)COc1ccccc1Cn1nc(-c2cccs2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O 10.1016/s0960-894x(00)00513-8
3795752 214900 0 None None None Human 6.6 pIC50 = 6.6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 320 3 1 4 3.4 Cc1noc(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1C 10.1016/0960-894X(96)00441-6
CHEMBL311455 214900 0 None None None Human 6.6 pIC50 = 6.6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 320 3 1 4 3.4 Cc1noc(NS(=O)(=O)c2cc(Cl)ccc2Cl)c1C 10.1016/0960-894X(96)00441-6
155560344 123015 36 None None None Pig 6.6 pIC50 = 6.6 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 641 12 4 7 4.8 CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
44283453 123015 36 None None None Pig 6.6 pIC50 = 6.6 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 641 12 4 7 4.8 CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
5311032 123015 36 None None None Pig 6.6 pIC50 = 6.6 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 641 12 4 7 4.8 CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
CHEMBL1741040 123015 36 None None None Pig 6.6 pIC50 = 6.6 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 641 12 4 7 4.8 CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
CHEMBL37807 123015 36 None None None Pig 6.6 pIC50 = 6.6 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 641 12 4 7 4.8 CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
CHEMBL4596821 123015 36 None None None Pig 6.6 pIC50 = 6.6 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 641 12 4 7 4.8 CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
10721106 124165 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 536 9 4 5 4.3 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL177023 124165 0 None None None Rat 6.6 pIC50 = 6.6 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 536 9 4 5 4.3 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
10247887 198636 0 None None None Human 5.6 pIC50 = 5.6 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 359 5 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(CN(C)C)cccc23)c1C 10.1021/jm00029a001
CHEMBL27525 198636 0 None None None Human 5.6 pIC50 = 5.6 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 359 5 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(CN(C)C)cccc23)c1C 10.1021/jm00029a001
10247887 198636 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 5 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(CN(C)C)cccc23)c1C 10.1021/jm00008a013
CHEMBL27525 198636 0 None None None Rat 5.6 pIC50 = 5.6 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 5 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(CN(C)C)cccc23)c1C 10.1021/jm00008a013
CHEMBL86814 489396 0 None None None Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cellsDisplacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cells
ChEMBL 847 24 9 8 2.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81215-4
CHEMBL408141 488004 0 None None None Rat 5.6 pIC50 = 5.6 Binding
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1496 31 18 19 0.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
CHEMBL86814 489396 0 None None None Human 5.6 pIC50 = 5.6 Binding
Inhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cellsInhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cells
ChEMBL 847 24 9 8 2.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00095a029
CHEMBL344473 487098 0 None None None Pig 5.6 pIC50 = 5.6 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 586 7 8 7 -1.2 CC(C)[C@@H]1NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](C)NC1=O 10.1021/jm00021a021
10444974 199797 27 None None None Human 4.6 pIC50 = 4.6 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)on1 10.1021/jm00029a001
CHEMBL283941 199797 27 None None None Human 4.6 pIC50 = 4.6 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)on1 10.1021/jm00029a001
10444974 199797 27 None None None Rat 4.6 pIC50 = 4.6 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)on1 10.1021/jm00008a013
CHEMBL283941 199797 27 None None None Rat 4.6 pIC50 = 4.6 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)on1 10.1021/jm00008a013
127035084 273828 0 None None None Human 4.6 pIC50 = 4.6 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 707 13 2 9 7.4 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735151 273828 0 None None None Human 4.6 pIC50 = 4.6 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 707 13 2 9 7.4 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
44298395 200833 0 None None None Rat 4.6 pIC50 = 4.6 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 308 3 1 4 3.4 Cc1onc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1C 10.1016/s0960-894x(00)00366-8
CHEMBL292355 200833 0 None None None Rat 4.6 pIC50 = 4.6 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 308 3 1 4 3.4 Cc1onc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1C 10.1016/s0960-894x(00)00366-8
44298342 201869 0 None None None Rat 4.6 pIC50 = 4.6 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 283 3 2 5 2.1 Cc1snc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/s0960-894x(00)00366-8
CHEMBL299831 201869 0 None None None Rat 4.6 pIC50 = 4.6 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 283 3 2 5 2.1 Cc1snc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/s0960-894x(00)00366-8
18184179 256956 0 None None None Human 5.6 pIC50 = 5.6 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 654 13 2 12 4.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccncc2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL367017 256956 0 None None None Human 5.6 pIC50 = 5.6 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 654 13 2 12 4.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccncc2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
52950137 42294 0 None None None Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 559 10 3 8 3.8 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC(=O)O)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1271863 42294 0 None None None Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 559 10 3 8 3.8 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC(=O)O)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
10760657 122799 0 None None None Rat 5.5 pIC50 = 5.5 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 355 7 1 6 4.0 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccoc1 10.1021/jm990378b
CHEMBL173565 122799 0 None None None Rat 5.5 pIC50 = 5.5 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 355 7 1 6 4.0 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccoc1 10.1021/jm990378b
10717279 197369 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 425 9 1 5 4.8 CCCCCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL266996 197369 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 425 9 1 5 4.8 CCCCCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
18948954 332660 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 360 4 2 5 3.5 Cc1noc(NS(=O)(=O)c2cccc3c(C(C)(C)O)cccc23)c1C 10.1021/jm00008a013
CHEMBL431300 332660 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 360 4 2 5 3.5 Cc1noc(NS(=O)(=O)c2cccc3c(C(C)(C)O)cccc23)c1C 10.1021/jm00008a013
11783885 201029 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 382 7 1 5 4.6 CCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm031041j
CHEMBL293702 201029 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 382 7 1 5 4.6 CCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm031041j
18617340 215098 0 None None None Human 7.5 pIC50 = 7.5 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 422 4 1 4 3.9 CCc1ccc(Br)c(S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/0960-894X(96)00441-6
CHEMBL311742 215098 0 None None None Human 7.5 pIC50 = 7.5 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 422 4 1 4 3.9 CCc1ccc(Br)c(S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/0960-894X(96)00441-6
11783885 201029 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 382 7 1 5 4.6 CCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm010382z
CHEMBL293702 201029 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 382 7 1 5 4.6 CCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm010382z
10457385 222165 0 None None None Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 469 6 1 8 2.5 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/j.bmcl.2016.06.014
155511294 222165 0 None None None Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 469 6 1 8 2.5 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/j.bmcl.2016.06.014
CHEMBL330424 222165 0 None None None Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 469 6 1 8 2.5 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/j.bmcl.2016.06.014
CHEMBL4435789 222165 0 None None None Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 469 6 1 8 2.5 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/j.bmcl.2016.06.014
44293805 201248 0 None None None Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 545 10 2 10 3.5 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCc1nn[nH]n1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL295140 201248 0 None None None Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 545 10 2 10 3.5 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCc1nn[nH]n1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
10693679 474272 0 None None None Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 425 10 2 5 4.7 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C(N)=O 10.1021/jm9707131
CHEMBL93749 474272 0 None None None Rat 7.5 pIC50 = 7.5 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 425 10 2 5 4.7 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C(N)=O 10.1021/jm9707131
9848132 474462 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 483 6 1 8 2.8 Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL94918 474462 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 483 6 1 8 2.8 Cc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
44387111 331025 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 548 10 5 5 4.2 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O 10.1021/jm950592+
CHEMBL426413 331025 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 548 10 5 5 4.2 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O 10.1021/jm950592+
10506505 256605 0 None None None Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 535 11 4 5 4.8 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@@H](CC(=O)NC2CCCCC2)CC(C)C)nc1C(=O)O 10.1021/jm9505932
CHEMBL366805 256605 0 None None None Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 535 11 4 5 4.8 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@@H](CC(=O)NC2CCCCC2)CC(C)C)nc1C(=O)O 10.1021/jm9505932
CHEMBL137716 484670 0 None None None Pig 7.5 pIC50 = 7.5 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 668 7 5 9 0.9 COC(=O)n1cc(C[C@@H]2NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H]3CCCN3C(=O)[C@H](CC(=O)O)NC2=O)c2ccccc21 10.1021/jm00021a021
137655525 314846 0 None None None Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 525 7 3 9 3.5 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(O)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4096346 314846 0 None None None Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 525 7 3 9 3.5 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(O)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
10383850 199957 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 5 1 5 3.6 CCc1c(C)noc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm00008a013
CHEMBL285122 199957 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 5 1 5 3.6 CCc1c(C)noc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm00008a013
10882352 468038 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 340 4 1 5 3.4 CCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm010382z
CHEMBL63099 468038 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 340 4 1 5 3.4 CCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm010382z
44279383 200173 0 None None None Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 398 3 2 3 4.2 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccccc3)cc21 10.1016/0960-894X(95)00230-Q
CHEMBL286687 200173 0 None None None Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 398 3 2 3 4.2 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccccc3)cc21 10.1016/0960-894X(95)00230-Q
23445221 468141 0 None None None Human 6.5 pIC50 = 6.5 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 470 5 1 7 4.4 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00367-3
CHEMBL63937 468141 0 None None None Human 6.5 pIC50 = 6.5 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 470 5 1 7 4.4 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00367-3
44327237 474791 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 511 8 1 8 3.5 CCCc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL96847 474791 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 511 8 1 8 3.5 CCCc1cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
15453172 469853 4 None None None Human 5.5 pIC50 = 5.5 Binding
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 392 4 1 4 4.2 Cc1noc(NS(=O)(=O)c2ccc(-c3ccccc3)cc2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL76623 469853 4 None None None Human 5.5 pIC50 = 5.5 Binding
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 392 4 1 4 4.2 Cc1noc(NS(=O)(=O)c2ccc(-c3ccccc3)cc2)c1Br 10.1016/0960-894X(96)00441-6
44213923 217893 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 563 8 1 8 4.1 COc1ccc(C2=NN(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)C(=O)CC2)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL319743 217893 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 563 8 1 8 4.1 COc1ccc(C2=NN(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)C(=O)CC2)cc1 10.1016/S0960-894X(96)00617-8
10530457 124862 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 538 9 5 6 4.0 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)NO 10.1021/jm950592+
CHEMBL177602 124862 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 538 9 5 6 4.0 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)NO 10.1021/jm950592+
10168939 259255 0 None None None Human 6.5 pIC50 = 6.5 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 695 11 2 12 5.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
CHEMBL368860 259255 0 None None None Human 6.5 pIC50 = 6.5 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 695 11 2 12 5.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
CHEMBL170600 484755 0 None None None Human 6.5 pIC50 = 6.5 Binding
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 571 12 5 6 2.3 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)N[C@H](CC(=O)O)C(=O)O 10.1016/0960-894X(95)00144-I
CHEMBL1201469 38416 0 None None None Human 5.5 pIC50 = 5.5 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL None None None None nan
23445227 239451 0 None None None Human 6.5 pIC50 = 6.5 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 472 6 1 8 3.9 Cc1noc(NS(=O)(=O)c2ccsc2COc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00132-7
CHEMBL355800 239451 0 None None None Human 6.5 pIC50 = 6.5 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 472 6 1 8 3.9 Cc1noc(NS(=O)(=O)c2ccsc2COc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00132-7
10789525 124522 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 8 1 6 4.4 COc1ccc(C(=O)/C(Cc2cccc(OC)c2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
CHEMBL177221 124522 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 8 1 6 4.4 COc1ccc(C(=O)/C(Cc2cccc(OC)c2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
10789524 19530 0 None None None Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 446 6 1 7 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OC)c2)cc1 10.1021/jm9606507
CHEMBL10607 19530 0 None None None Human 8.5 pIC50 = 8.5 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 446 6 1 7 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OC)c2)cc1 10.1021/jm9606507
10896413 200757 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 504 9 1 7 5.4 COc1ccc(CCOC2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL291841 200757 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 504 9 1 7 5.4 COc1ccc(CCOC2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
11762291 200784 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 6 1 6 5.2 COc1ccccc1C1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL292041 200784 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 6 1 6 5.2 COc1ccccc1C1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
11059249 202679 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 440 10 1 6 5.3 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OCCCC)cc21 10.1021/jm010382z
CHEMBL304202 202679 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 440 10 1 6 5.3 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OCCCC)cc21 10.1021/jm010382z
11144468 468475 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 430 5 1 5 5.2 CC(C)Oc1ccc2c(c1)C(c1ccccc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL65925 468475 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 430 5 1 5 5.2 CC(C)Oc1ccc2c(c1)C(c1ccccc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
10184817 23878 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 488 14 1 5 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)CCC 10.1021/jm980217s
CHEMBL112417 23878 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 488 14 1 5 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)CCC 10.1021/jm980217s
44314904 203196 0 None None None Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL 585 12 5 5 3.6 CSCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
CHEMBL307936 203196 0 None None None Human 8.5 pIC50 = 8.5 Binding
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL 585 12 5 5 3.6 CSCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
155564169 349340 0 None None None Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 545 11 1 12 2.0 COc1ccc(Cl)c(Oc2c(NS(C)(=O)=O)ncnc2OCCOc2ncc(S(C)(=O)=O)cn2)c1 10.1016/j.bmcl.2016.06.014
CHEMBL4574034 349340 0 None None None Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 545 11 1 12 2.0 COc1ccc(Cl)c(Oc2c(NS(C)(=O)=O)ncnc2OCCOc2ncc(S(C)(=O)=O)cn2)c1 10.1016/j.bmcl.2016.06.014
71455062 163108 0 None None None Human 8.5 pIC50 = 8.5 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 669 14 1 12 5.0 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(C(F)(F)F)cn1 10.1021/jm3009103
CHEMBL2163705 163108 0 None None None Human 8.5 pIC50 = 8.5 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 669 14 1 12 5.0 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(C(F)(F)F)cn1 10.1021/jm3009103
44295005 24518 0 None None None Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 538 10 1 9 4.8 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)c(F)c1 10.1016/s0960-894x(98)00301-1
CHEMBL1160205 24518 0 None None None Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 538 10 1 9 4.8 COc1ccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)c(F)c1 10.1016/s0960-894x(98)00301-1
10226215 201555 0 None None None Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 2 8 3.8 Cc1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm9608366
CHEMBL297473 201555 0 None None None Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 2 8 3.8 Cc1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm9608366
44291255 347556 0 None None None Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 2 8 3.8 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2C)OCO3)c1Cl 10.1021/jm9700068
CHEMBL45296 347556 0 None None None Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 455 5 2 8 3.8 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2C)OCO3)c1Cl 10.1021/jm9700068
CHEMBL414165 488327 0 None None None Pig 8.5 pIC50 = 8.5 Binding
Inhibitory effect against porcine ET-A receptorInhibitory effect against porcine ET-A receptor
ChEMBL 650 7 6 7 1.6 CC(C)C[C@H]1NC(=O)[C@H](c2cccs2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44311345 469142 0 None None None Human 8.5 pIC50 = 8.5 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 663 13 3 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CCNCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70895 469142 0 None None None Human 8.5 pIC50 = 8.5 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 663 13 3 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CCNCC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL414165 488327 0 None None None Pig 8.5 pIC50 = 8.5 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 650 7 6 7 1.6 CC(C)C[C@H]1NC(=O)[C@H](c2cccs2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
8260 1098 43 None None None Human 8.5 pIC50 = 8.5 Binding
Antagonist activity at ETA receptor (unknown origin) in presence of ET1Antagonist activity at ETA receptor (unknown origin) in presence of ET1
ChEMBL 479 8 1 9 3.9 COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 10.1016/j.bmcl.2016.06.014
9912992 1098 43 None None None Human 8.5 pIC50 = 8.5 Binding
Antagonist activity at ETA receptor (unknown origin) in presence of ET1Antagonist activity at ETA receptor (unknown origin) in presence of ET1
ChEMBL 479 8 1 9 3.9 COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 10.1016/j.bmcl.2016.06.014
CHEMBL3989834 1098 43 None None None Human 8.5 pIC50 = 8.5 Binding
Antagonist activity at ETA receptor (unknown origin) in presence of ET1Antagonist activity at ETA receptor (unknown origin) in presence of ET1
ChEMBL 479 8 1 9 3.9 COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1 10.1016/j.bmcl.2016.06.014
44458597 199034 0 None None None Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 535 7 3 8 2.3 Cn1cc(C(C(=O)NS(=O)(=O)c2ccccc2C(=O)O)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1016/s0960-894x(01)00660-6
CHEMBL278349 199034 0 None None None Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 535 7 3 8 2.3 Cn1cc(C(C(=O)NS(=O)(=O)c2ccccc2C(=O)O)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1016/s0960-894x(01)00660-6
11017071 24257 0 None None None Pig 8.5 pIC50 = 8.5 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 547 9 1 9 4.3 Cc1ccc(-c2c(NS(=O)(=O)c3cccs3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
CHEMBL114683 24257 0 None None None Pig 8.5 pIC50 = 8.5 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 547 9 1 9 4.3 Cc1ccc(-c2c(NS(=O)(=O)c3cccs3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
10994373 317946 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 5 1 7 5.0 CC(C)Oc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL416675 317946 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 5 1 7 5.0 CC(C)Oc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
10122033 163106 0 None None None Human 8.5 pIC50 = 8.5 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 631 15 1 13 4.0 COc1cnc(OCCOc2nc(-c3ncccn3)nc(NS(=O)(=O)CCc3ccccc3)c2Oc2ccccc2OC)nc1 10.1021/jm3009103
CHEMBL2163703 163106 0 None None None Human 8.5 pIC50 = 8.5 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 631 15 1 13 4.0 COc1cnc(OCCOc2nc(-c3ncccn3)nc(NS(=O)(=O)CCc3ccccc3)c2Oc2ccccc2OC)nc1 10.1021/jm3009103
44334145 18995 0 None None None Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 460 6 1 6 4.6 COc1ccc([C@@H]2c3nc(N(C)C(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
CHEMBL103090 18995 0 None None None Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 460 6 1 6 4.6 COc1ccc([C@@H]2c3nc(N(C)C(C)C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
44352026 236327 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 548 11 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C(F)(F)F)cc1 10.1021/jm010237l
CHEMBL339969 236327 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 548 11 1 5 5.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C(F)(F)F)cc1 10.1021/jm010237l
44339840 23593 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 486 13 1 5 5.1 C/C=C(\C)CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
CHEMBL110904 23593 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 486 13 1 5 5.1 C/C=C(\C)CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
10577829 23971 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 518 13 1 7 3.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1OCCCO1 10.1021/jm980217s
CHEMBL112877 23971 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 518 13 1 7 3.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1OCCCO1 10.1021/jm980217s
73669821 236466 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Displacement of PD156707 from rat ETA receptor after 1 hr by Lowry methodDisplacement of PD156707 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 448 10 1 6 5.2 CC(=O)c1ccc(OCc2ccc3c(c2)OCO3)cc1OC(CCC(=O)O)c1ccccc1 10.1016/j.bmc.2015.01.003
CHEMBL3400988 236466 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Displacement of PD156707 from rat ETA receptor after 1 hr by Lowry methodDisplacement of PD156707 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 448 10 1 6 5.2 CC(=O)c1ccc(OCc2ccc3c(c2)OCO3)cc1OC(CCC(=O)O)c1ccccc1 10.1016/j.bmc.2015.01.003
21041307 348998 0 None None None Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 482 10 2 9 2.6 CNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4566095 348998 0 None None None Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 482 10 2 9 2.6 CNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1-c1ccc(Cl)cc1 10.1016/j.bmcl.2016.06.014
10274552 155206 0 None None None Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 434 6 1 8 3.6 Cc1cc2c(cc1CC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C)OCO2 10.1021/jm9700068
CHEMBL20168 155206 0 None None None Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 434 6 1 8 3.6 Cc1cc2c(cc1CC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C)OCO2 10.1021/jm9700068
10274552 155206 0 None None None Human 8.5 pIC50 = 8.5 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 434 6 1 8 3.6 Cc1cc2c(cc1CC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C)OCO2 10.1021/jm000349x
CHEMBL20168 155206 0 None None None Human 8.5 pIC50 = 8.5 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 434 6 1 8 3.6 Cc1cc2c(cc1CC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C)OCO2 10.1021/jm000349x
16004692 4984 61 None None None Human 8.5 pIC50 = 8.5 Binding
Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1016/j.bmcl.2016.06.014
4809 4984 61 None None None Human 8.5 pIC50 = 8.5 Binding
Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1016/j.bmcl.2016.06.014
7352 4984 61 None None None Human 8.5 pIC50 = 8.5 Binding
Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1016/j.bmcl.2016.06.014
CHEMBL2103873 4984 61 None None None Human 8.5 pIC50 = 8.5 Binding
Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1016/j.bmcl.2016.06.014
DB08932 4984 61 None None None Human 8.5 pIC50 = 8.5 Binding
Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1
ChEMBL 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br 10.1016/j.bmcl.2016.06.014
10070 927 52 None None None Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 10.1016/j.bmcl.2016.06.014
25099191 927 52 None None None Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 10.1016/j.bmcl.2016.06.014
CHEMBL2165326 927 52 None None None Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 10.1016/j.bmcl.2016.06.014
DB15059 927 52 None None None Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 10.1016/j.bmcl.2016.06.014
10070 927 52 None None None Human 8.5 pIC50 = 8.5 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 10.1021/jm3009103
25099191 927 52 None None None Human 8.5 pIC50 = 8.5 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 10.1021/jm3009103
CHEMBL2165326 927 52 None None None Human 8.5 pIC50 = 8.5 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 10.1021/jm3009103
DB15059 927 52 None None None Human 8.5 pIC50 = 8.5 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 544 8 2 8 2.5 Brc1ccc(cc1)c1c(OCCOc2ncc(cn2)Br)ncnc1NS(=O)(=O)N 10.1021/jm3009103
71455065 163128 0 None None None Human 8.5 pIC50 = 8.5 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 679 14 2 11 4.8 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2ccncc2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163724 163128 0 None None None Human 8.5 pIC50 = 8.5 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 679 14 2 11 4.8 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)nc(-c2ccncc2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
17869373 38540 0 None None None Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 460 8 1 7 4.7 COc1ccc(C(=O)/C(Cc2cccc(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1205094 38540 0 None None None Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 460 8 1 7 4.7 COc1ccc(C(=O)/C(Cc2cccc(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
44295106 38646 0 None None None Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 472 7 1 7 4.6 COc1ccc(C(=O)/C(Cc2ccc3c(c2)CCO3)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1206319 38646 0 None None None Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 472 7 1 7 4.6 COc1ccc(C(=O)/C(Cc2ccc3c(c2)CCO3)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
17869279 38779 0 None None None Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 460 8 1 7 4.7 COc1ccc(C(=O)/C(Cc2ccccc2OC)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1207701 38779 0 None None None Rat 8.5 pIC50 = 8.5 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 460 8 1 7 4.7 COc1ccc(C(=O)/C(Cc2ccccc2OC)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
44320171 216612 0 None None None Rat 8.5 pIC50 = 8.5 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 504 6 1 5 6.4 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC12CC3CC(CC(C3)C1)C2 10.1016/s0960-894x(00)00513-8
CHEMBL314974 216612 0 None None None Rat 8.5 pIC50 = 8.5 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 504 6 1 5 6.4 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC12CC3CC(CC(C3)C1)C2 10.1016/s0960-894x(00)00513-8
11135910 24509 0 None None None Pig 8.5 pIC50 = 8.5 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 624 10 1 10 5.4 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
CHEMBL116002 24509 0 None None None Pig 8.5 pIC50 = 8.5 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 624 10 1 10 5.4 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm0102304
10205245 144429 0 None None None Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 466 5 2 9 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2C#N)OCO3)c1Cl 10.1021/jm9608366
CHEMBL19808 144429 0 None None None Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 466 5 2 9 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2C#N)OCO3)c1Cl 10.1021/jm9608366
44291575 353326 0 None None None Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 466 5 2 9 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2C#N)OCO3)c1Cl 10.1021/jm9700068
CHEMBL47404 353326 0 None None None Human 8.5 pIC50 = 8.5 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 466 5 2 9 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc3c(c2C#N)OCO3)c1Cl 10.1021/jm9700068
10205245 144429 0 None None None Human 8.5 pIC50 = 8.5 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 466 5 2 9 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2C#N)OCO3)c1Cl 10.1021/jm000349x
CHEMBL19808 144429 0 None None None Human 8.5 pIC50 = 8.5 Binding
Inhibitory concentration was determined against selective Endothelin A receptorInhibitory concentration was determined against selective Endothelin A receptor
ChEMBL 466 5 2 9 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2C#N)OCO3)c1Cl 10.1021/jm000349x
CHEMBL133257 484639 0 None None None Human 8.5 pIC50 = 8.5 Binding
Inhibitory effect against Human ET-A receptorInhibitory effect against Human ET-A receptor
ChEMBL 636 7 6 6 1.4 CC(C)C[C@H]1NC(=O)[C@H](C2CCCC2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
11634755 125045 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 480 7 1 7 4.9 COc1cc(/C(C(=O)O)=C(\CC2CCCCC2)C(=O)c2ccc3c(c2)OCCO3)cc2c1OCO2 10.1021/jm031041j
CHEMBL177886 125045 0 None None None Rat 8.5 pIC50 = 8.5 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 480 7 1 7 4.9 COc1cc(/C(C(=O)O)=C(\CC2CCCCC2)C(=O)c2ccc3c(c2)OCCO3)cc2c1OCO2 10.1021/jm031041j
44304492 196896 0 None None None Human 8.5 pIC50 = 8.5 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 949 23 9 8 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL262993 196896 0 None None None Human 8.5 pIC50 = 8.5 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 949 23 9 8 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
18738878 387324 0 None None None Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 547 8 2 7 4.2 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1016/s0960-894x(01)00660-6
CHEMBL539420 387324 0 None None None Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 547 8 2 7 4.2 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1016/s0960-894x(01)00660-6
9958846 334735 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 537 13 1 10 3.7 COCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)CCc2ccccc2)c1Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
CHEMBL4444693 334735 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 537 13 1 10 3.7 COCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)CCc2ccccc2)c1Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
71455140 163435 0 None None None Human 8.4 pIC50 = 8.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 598 12 2 8 4.7 CC(C)c1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm3009103
CHEMBL2165336 163435 0 None None None Human 8.4 pIC50 = 8.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 598 12 2 8 4.7 CC(C)c1ccc(-c2c(NS(=O)(=O)NCc3ccccc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm3009103
11123269 473277 0 None None None Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 452 6 1 5 5.8 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
CHEMBL87070 473277 0 None None None Rat 8.4 pIC50 = 8.4 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 452 6 1 5 5.8 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
10697520 26388 0 None None None Human 8.4 pIC50 = 8.4 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 530 10 2 6 4.9 CCCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm990171i
CHEMBL1184086 26388 0 None None None Human 8.4 pIC50 = 8.4 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 530 10 2 6 4.9 CCCC(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1 10.1021/jm990171i
10530156 23861 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 526 14 1 6 5.0 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(OC)cc2OC)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL112347 23861 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 526 14 1 6 5.0 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc(OC)cc2OC)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
44295206 38694 0 None None None Rat 8.4 pIC50 = 8.4 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 580 12 1 11 4.7 COc1cc(C/C(C(=O)c2cc(OC)c(OC)c(OC)c2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
CHEMBL1206728 38694 0 None None None Rat 8.4 pIC50 = 8.4 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 580 12 1 11 4.7 COc1cc(C/C(C(=O)c2cc(OC)c(OC)c(OC)c2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
11059349 468522 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 6 1 6 4.8 CCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm031041j
CHEMBL66264 468522 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 6 1 6 4.8 CCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm031041j
15453178 214464 0 None None None Human 8.4 pIC50 = 8.4 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 348 4 1 4 4.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1Cl 10.1016/0960-894X(96)00441-6
CHEMBL310739 214464 0 None None None Human 8.4 pIC50 = 8.4 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 348 4 1 4 4.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1Cl 10.1016/0960-894X(96)00441-6
11059349 468522 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 446 6 1 6 4.8 CCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL66264 468522 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 446 6 1 6 4.8 CCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
44314610 202912 0 None None None Pig 8.4 pIC50 = 8.4 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 671 12 6 5 3.9 CC(C)CC(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)N[C@H](Cc1c(Br)[nH]c2ccccc12)C(=O)NC(Cc1c[nH]cn1)C(=O)O 10.1021/jm9600914
CHEMBL305650 202912 0 None None None Pig 8.4 pIC50 = 8.4 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 671 12 6 5 3.9 CC(C)CC(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)N[C@H](Cc1c(Br)[nH]c2ccccc12)C(=O)NC(Cc1c[nH]cn1)C(=O)O 10.1021/jm9600914
44314619 469576 0 None None None Pig 8.4 pIC50 = 8.4 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 631 12 5 4 4.5 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
CHEMBL73925 469576 0 None None None Pig 8.4 pIC50 = 8.4 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 631 12 5 4 4.5 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
71451529 163122 0 None None None Human 8.4 pIC50 = 8.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 632 14 2 12 3.4 CCCNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
CHEMBL2163719 163122 0 None None None Human 8.4 pIC50 = 8.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 632 14 2 12 3.4 CCCNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
10504920 328114 0 None None None Human 8.4 pIC50 = 8.4 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 480 6 2 9 3.5 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CC#N)OCO3)c1Cl 10.1021/jm9608366
CHEMBL417719 328114 0 None None None Human 8.4 pIC50 = 8.4 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 480 6 2 9 3.5 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CC#N)OCO3)c1Cl 10.1021/jm9608366
CHEMBL284250 484245 0 None None None Pig 8.4 pIC50 = 8.4 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 631 12 5 4 4.5 CCCC[C@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1016/0960-894X(95)00237-N
10579100 331169 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 578 10 2 6 5.4 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(Cc2ccccc2)c2ccccc2)cc1 10.1021/jm031041j
CHEMBL427303 331169 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 578 10 2 6 5.4 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(Cc2ccccc2)c2ccccc2)cc1 10.1021/jm031041j
10579100 331169 0 None None None Human 8.4 pIC50 = 8.4 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 578 10 2 6 5.4 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(Cc2ccccc2)c2ccccc2)cc1 10.1021/jm990171i
CHEMBL427303 331169 0 None None None Human 8.4 pIC50 = 8.4 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 578 10 2 6 5.4 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(Cc2ccccc2)c2ccccc2)cc1 10.1021/jm990171i
10695363 19591 0 None None None Human 8.4 pIC50 = 8.4 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 462 6 1 7 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(SC)cc2)cc1 10.1021/jm9606507
CHEMBL10636 19591 0 None None None Human 8.4 pIC50 = 8.4 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 462 6 1 7 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(SC)cc2)cc1 10.1021/jm9606507
73669820 236467 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 462 10 1 7 5.5 CC(=O)c1ccc(OCc2ccc3nsnc3c2)cc1OC(CCC(=O)O)c1ccccc1 10.1016/j.bmc.2015.01.003
CHEMBL3400989 236467 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 462 10 1 7 5.5 CC(=O)c1ccc(OCc2ccc3nsnc3c2)cc1OC(CCC(=O)O)c1ccccc1 10.1016/j.bmc.2015.01.003
44380952 61154 0 None None None Pig 8.4 pIC50 = 8.4 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 679 10 1 9 7.3 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)nc(-c3cccs3)nc2OCCOc2ncc(Br)cn2)cc1 10.1016/s0960-894x(01)00682-5
CHEMBL136871 61154 0 None None None Pig 8.4 pIC50 = 8.4 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 679 10 1 9 7.3 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)nc(-c3cccs3)nc2OCCOc2ncc(Br)cn2)cc1 10.1016/s0960-894x(01)00682-5
44291897 201423 0 None None None Human 8.4 pIC50 = 8.4 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 482 7 2 9 3.6 COc1cc(C#N)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(OC)c1 10.1021/jm9608366
CHEMBL296456 201423 0 None None None Human 8.4 pIC50 = 8.4 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 482 7 2 9 3.6 COc1cc(C#N)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(OC)c1 10.1021/jm9608366
9956918 335428 0 None None None Human 8.4 pIC50 = 8.4 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 482 7 2 9 3.6 COc1cc(C#N)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1OC 10.1021/jm9700068
CHEMBL44544 335428 0 None None None Human 8.4 pIC50 = 8.4 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 482 7 2 9 3.6 COc1cc(C#N)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1OC 10.1021/jm9700068
44279172 218244 0 None None None Human 8.4 pIC50 = 8.4 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 532 10 2 6 4.6 CCCCCNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccccc1 10.1016/S0960-894X(97)00228-X
CHEMBL32075 218244 0 None None None Human 8.4 pIC50 = 8.4 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 532 10 2 6 4.6 CCCCCNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccccc1 10.1016/S0960-894X(97)00228-X
10022121 201937 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 371 4 1 5 3.8 Cc1noc(NS(=O)(=O)c2cccc3c(N4CCCC4)cccc23)c1C 10.1021/jm00008a013
CHEMBL30032 201937 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 371 4 1 5 3.8 Cc1noc(NS(=O)(=O)c2cccc3c(N4CCCC4)cccc23)c1C 10.1021/jm00008a013
9957225 19602 0 None None None Human 7.5 pIC50 = 7.5 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 490 8 0 8 4.7 COc1ccc(C2OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
CHEMBL10644 19602 0 None None None Human 7.5 pIC50 = 7.5 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 490 8 0 8 4.7 COc1ccc(C2OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
18738880 332898 0 None None None Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 561 8 2 7 4.5 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)NC)cc21 10.1016/s0960-894x(01)00660-6
CHEMBL433221 332898 0 None None None Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 561 8 2 7 4.5 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)NC)cc21 10.1016/s0960-894x(01)00660-6
10738157 122033 0 None None None Rat 7.5 pIC50 = 7.5 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 374 7 1 5 4.0 Cc1ccccc1C(Oc1cc(OCc2cccnc2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL170348 122033 0 None None None Rat 7.5 pIC50 = 7.5 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 374 7 1 5 4.0 Cc1ccccc1C(Oc1cc(OCc2cccnc2)ccc1C#N)C(=O)O 10.1021/jm990378b
10714797 239353 0 None None None Rat 7.5 pIC50 = 7.5 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 380 7 1 6 4.1 Cc1ccccc1C(Oc1cc(OCc2cncs2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL354740 239353 0 None None None Rat 7.5 pIC50 = 7.5 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 380 7 1 6 4.1 Cc1ccccc1C(Oc1cc(OCc2cncs2)ccc1C#N)C(=O)O 10.1021/jm990378b
10622380 201578 0 None None None Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 426 7 1 7 3.9 COc1cccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c1 10.1021/jm9700068
CHEMBL297679 201578 0 None None None Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 426 7 1 7 3.9 COc1cccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c1 10.1021/jm9700068
CHEMBL2369736 485466 0 None None None Human 7.5 pIC50 = 7.5 Binding
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 25 8 8 4.5 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N(C)[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm970161m
CHEMBL65559 489365 0 None None None Pig 7.5 pIC50 = 7.5 Binding
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL 907 21 9 8 3.2 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
9850566 18543 0 None None None Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 551 8 1 8 6.1 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OCc1ccccc1 10.1016/0960-894X(96)00170-9
CHEMBL10016 18543 0 None None None Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 551 8 1 8 6.1 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OCc1ccccc1 10.1016/0960-894X(96)00170-9
CHEMBL342615 487067 0 None None None Human 7.5 pIC50 = 7.5 Binding
Inhibitory effect against Human Endothelin A receptorInhibitory effect against Human Endothelin A receptor
ChEMBL 646 7 6 7 0.2 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44311527 469064 0 None None None Human 7.5 pIC50 = 7.5 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 675 12 2 11 7.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2cccs2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70365 469064 0 None None None Human 7.5 pIC50 = 7.5 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 675 12 2 11 7.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2cccs2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL148751 484699 0 None None None Human 7.5 pIC50 = 7.5 Binding
The inhibitory constant was evaluated against Endothelin A receptorThe inhibitory constant was evaluated against Endothelin A receptor
ChEMBL 881 24 8 8 3.1 CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)CN(Cc1ccccc1)C(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
10836474 124531 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 432 9 1 5 4.7 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc(OC)cc2OC)cc1 10.1021/jm031041j
CHEMBL177287 124531 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 432 9 1 5 4.7 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc(OC)cc2OC)cc1 10.1021/jm031041j
10788853 20440 0 None None None Human 6.5 pIC50 = 6.5 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 7 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc(OC)cc3OC)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL10808 20440 0 None None None Human 6.5 pIC50 = 6.5 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 7 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc(OC)cc3OC)=C2Cc2ccccc2)cc1 10.1021/jm9606507
10717504 198778 0 None None None Human 6.5 pIC50 = 6.5 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 430 6 0 6 4.5 COc1ccc(C2(OC)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL276173 198778 0 None None None Human 6.5 pIC50 = 6.5 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 430 6 0 6 4.5 COc1ccc(C2(OC)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
10717504 198778 0 None None None Human 6.5 pIC50 = 6.5 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 430 6 0 6 4.5 COc1ccc(C2(OC)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1016/S0960-894X(97)00002-4
CHEMBL276173 198778 0 None None None Human 6.5 pIC50 = 6.5 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 430 6 0 6 4.5 COc1ccc(C2(OC)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1016/S0960-894X(97)00002-4
10522605 473724 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 361 6 1 4 5.0 Cc1ccccc1/C(=C\c1cc(OCc2ccsc2)ccc1C#N)CO 10.1021/jm970847e
CHEMBL90191 473724 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 361 6 1 4 5.0 Cc1ccccc1/C(=C\c1cc(OCc2ccsc2)ccc1C#N)CO 10.1021/jm970847e
10595639 473995 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 375 6 1 4 5.1 Cc1ccccc1/C(=C\c1cc(OCc2ccsc2)ccc1C#N)C(=O)O 10.1021/jm970847e
CHEMBL91810 473995 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 375 6 1 4 5.1 Cc1ccccc1/C(=C\c1cc(OCc2ccsc2)ccc1C#N)C(=O)O 10.1021/jm970847e
10697377 123848 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 523 10 4 6 4.2 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL176513 123848 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 523 10 4 6 4.2 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL3349461 486809 0 None None None Pig 5.5 pIC50 = 5.5 Binding
Binding activity against Endothelin A receptor of Porcine aortic smooth muscle membranesBinding activity against Endothelin A receptor of Porcine aortic smooth muscle membranes
ChEMBL 598 8 7 6 0.7 CC(C)C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00089a028
18617366 332596 0 None None None Human 5.5 pIC50 = 5.5 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 394 3 1 4 3.3 Cc1noc(NS(=O)(=O)c2ccc(Br)cc2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL430822 332596 0 None None None Human 5.5 pIC50 = 5.5 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 394 3 1 4 3.3 Cc1noc(NS(=O)(=O)c2ccc(Br)cc2)c1Br 10.1016/0960-894X(96)00441-6
44314864 203086 0 None None None Pig 5.5 pIC50 = 5.5 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 566 11 5 5 3.4 CCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1021/jm9600914
CHEMBL307077 203086 0 None None None Pig 5.5 pIC50 = 5.5 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 566 11 5 5 3.4 CCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1021/jm9600914
10788691 473709 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 428 6 1 3 6.0 Cc1ccccc1/C(=C\c1cc(OCc2ccsc2)ccc1Br)C(=O)O 10.1021/jm970847e
CHEMBL90094 473709 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 428 6 1 3 6.0 Cc1ccccc1/C(=C\c1cc(OCc2ccsc2)ccc1Br)C(=O)O 10.1021/jm970847e
127035544 273807 0 None None None Human 5.5 pIC50 = 5.5 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 721 14 2 9 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3734870 273807 0 None None None Human 5.5 pIC50 = 5.5 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 721 14 2 9 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3cc(OC)ccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
10549875 122578 0 None None None Rat 5.5 pIC50 = 5.5 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2cccc3c2OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL172691 122578 0 None None None Rat 5.5 pIC50 = 5.5 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2cccc3c2OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL2367550 485394 0 None None None Human 5.5 pIC50 = 5.5 Binding
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 25 8 8 4.5 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm970161m
10506524 123940 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 536 9 4 5 4.2 CNC(=O)c1nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)oc1C 10.1021/jm950592+
CHEMBL176565 123940 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 536 9 4 5 4.2 CNC(=O)c1nc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)oc1C 10.1021/jm950592+
10743900 255751 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 497 11 4 5 4.0 CCN(CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C)o1 10.1021/jm950592+
CHEMBL366387 255751 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 497 11 4 5 4.0 CCN(CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C)o1 10.1021/jm950592+
CHEMBL432683 488585 0 None None None Pig 5.5 pIC50 = 5.5 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 598 8 7 6 0.7 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44368396 97878 0 None None None Pig 4.5 pIC50 = 4.5 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 506 8 2 5 4.9 COc1ccc(C(=O)N(Cc2cc3c(cc2Cl)OCO3)C(Cc2c[nH]c3ccccc23)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
CHEMBL152017 97878 0 None None None Pig 4.5 pIC50 = 4.5 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 506 8 2 5 4.9 COc1ccc(C(=O)N(Cc2cc3c(cc2Cl)OCO3)C(Cc2c[nH]c3ccccc23)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
95285 197585 29 None None None Rat 4.5 pIC50 = 4.5 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 256 3 2 5 1.7 O=S(=O)(Nc1nccs1)c1ccc(O)cc1 10.1021/jm00008a013
CHEMBL26894 197585 29 None None None Rat 4.5 pIC50 = 4.5 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 256 3 2 5 1.7 O=S(=O)(Nc1nccs1)c1ccc(O)cc1 10.1021/jm00008a013
CHEMBL1791272 484826 0 None None None Human 4.5 pIC50 = 4.5 Binding
Inhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cellsInhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cells
ChEMBL 847 24 9 8 2.6 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)[C@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00152-J
10027408 197462 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 463 10 2 5 6.1 Cc1noc(NS(=O)(=O)c2cccc3c(NCCCCCc4ccccc4)cccc23)c1C 10.1021/jm00008a013
CHEMBL26786 197462 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 463 10 2 5 6.1 Cc1noc(NS(=O)(=O)c2cccc3c(NCCCCCc4ccccc4)cccc23)c1C 10.1021/jm00008a013
23445410 215825 0 None None None Human 6.5 pIC50 = 6.5 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 412 4 1 5 4.6 Cc1ccccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL313551 215825 0 None None None Human 6.5 pIC50 = 6.5 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 412 4 1 5 4.6 Cc1ccccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(96)00496-9
23445379 258013 0 None None None Human 6.5 pIC50 = 6.5 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 456 6 1 6 4.8 Cc1ccc(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00132-7
CHEMBL367776 258013 0 None None None Human 6.5 pIC50 = 6.5 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 456 6 1 6 4.8 Cc1ccc(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00132-7
44459299 180436 0 None None None Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 520 7 3 6 4.4 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2c[nH]c3cc(C(=O)O)ccc23)cc1 10.1016/s0960-894x(01)00660-6
CHEMBL23752 180436 0 None None None Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 520 7 3 6 4.4 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2c[nH]c3cc(C(=O)O)ccc23)cc1 10.1016/s0960-894x(01)00660-6
44293754 202070 0 None None None Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 531 9 2 10 3.5 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCC(=O)O)N(c1nn[nH]n1)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL301371 202070 0 None None None Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 531 9 2 10 3.5 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCC(=O)O)N(c1nn[nH]n1)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
10552051 201304 0 None None None Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 463 6 2 9 3.3 CC(=O)c1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C)OCO2 10.1021/jm9608366
CHEMBL295583 201304 0 None None None Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 463 6 2 9 3.3 CC(=O)c1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C)OCO2 10.1021/jm9608366
18704821 200009 0 None None None Human 7.5 pIC50 = 7.5 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 419 5 1 5 3.7 COc1nc(Br)cnc1NS(=O)(=O)c1ccccc1-c1ccccc1 10.1016/S0960-894X(97)00228-X
CHEMBL285512 200009 0 None None None Human 7.5 pIC50 = 7.5 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 419 5 1 5 3.7 COc1nc(Br)cnc1NS(=O)(=O)c1ccccc1-c1ccccc1 10.1016/S0960-894X(97)00228-X
44279367 199943 0 None None None Pig 6.5 pIC50 = 6.5 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 485 11 5 4 2.0 CC(C)C[C@H](NC(=O)N1CCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL285031 199943 0 None None None Pig 6.5 pIC50 = 6.5 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 485 11 5 4 2.0 CC(C)C[C@H](NC(=O)N1CCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
10575356 24013 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 446 8 1 4 3.7 CCCN(C)C(=O)CN1C[C@H](c2ccc(F)c(F)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL113184 24013 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 446 8 1 4 3.7 CCCN(C)C(=O)CN1C[C@H](c2ccc(F)c(F)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
10551532 220109 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 450 8 1 4 3.9 CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)CCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL325444 220109 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 450 8 1 4 3.9 CCCN(C)C(=O)CN1C[C@H](c2ccc3c(c2)CCC3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
127035219 273805 0 None None None Human 6.5 pIC50 = 6.5 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 677 12 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3734849 273805 0 None None None Human 6.5 pIC50 = 6.5 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 677 12 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
44293719 196989 0 None None None Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 581 12 2 10 3.9 CCOc1ccc2c(c1)[C@@H](c1cc(OC)c(OC)c(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL263723 196989 0 None None None Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 581 12 2 10 3.9 CCOc1ccc2c(c1)[C@@H](c1cc(OC)c(OC)c(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
11800505 124975 0 None None None Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 536 11 3 6 5.1 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@@H](CC(=O)NC2CCCCC2)CC(C)C)nc1C(=O)O 10.1021/jm9505932
CHEMBL177839 124975 0 None None None Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 536 11 3 6 5.1 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@@H](CC(=O)NC2CCCCC2)CC(C)C)nc1C(=O)O 10.1021/jm9505932
10570511 474031 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 360 6 1 4 4.2 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/C(N)=O)c1ccccc1 10.1021/jm970847e
CHEMBL92092 474031 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 360 6 1 4 4.2 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/C(N)=O)c1ccccc1 10.1021/jm970847e
44276577 216516 0 None None None Rat 5.5 pIC50 = 5.5 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 459 7 1 7 4.1 COc1cccc(Cn2[nH]c(-c3ccc([N+](=O)[O-])cc3)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144850 216516 0 None None None Rat 5.5 pIC50 = 5.5 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 459 7 1 7 4.1 COc1cccc(Cn2[nH]c(-c3ccc([N+](=O)[O-])cc3)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
10357554 197867 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 302 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C 10.1021/jm00004a012
CHEMBL27065 197867 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 302 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C 10.1021/jm00004a012
44368539 98458 0 None None None Pig 4.5 pIC50 = 4.5 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 475 9 2 6 3.9 COc1cccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2ccc(O)cc2)C(=O)O)c1 10.1016/s0960-894x(01)00009-9
CHEMBL152552 98458 0 None None None Pig 4.5 pIC50 = 4.5 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 475 9 2 6 3.9 COc1cccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2ccc(O)cc2)C(=O)O)c1 10.1016/s0960-894x(01)00009-9
10476286 196771 0 None None None Rat 4.5 pIC50 = 4.5 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 403 6 1 7 3.2 CCOC(=O)c1c(C)noc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm00008a013
CHEMBL26206 196771 0 None None None Rat 4.5 pIC50 = 4.5 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 403 6 1 7 3.2 CCOC(=O)c1c(C)noc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm00008a013
127037496 273847 0 None None None Human 6.5 pIC50 = 6.5 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 613 12 2 7 6.9 CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 10.1039/C4MD00499J
CHEMBL3735311 273847 0 None None None Human 6.5 pIC50 = 6.5 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 613 12 2 7 6.9 CCCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 10.1039/C4MD00499J
22998508 473865 0 None None None Human 6.5 pIC50 = 6.5 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 412 4 1 5 4.6 Cc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(96)00496-9
CHEMBL91073 473865 0 None None None Human 6.5 pIC50 = 6.5 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 412 4 1 5 4.6 Cc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(96)00496-9
10020445 201497 0 None None None Rat 4.5 pIC50 = 4.5 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2ccc3cccc(N(C)C)c3c2)c1C 10.1021/jm00008a013
CHEMBL29705 201497 0 None None None Rat 4.5 pIC50 = 4.5 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2ccc3cccc(N(C)C)c3c2)c1C 10.1021/jm00008a013
10020445 201497 0 None None None Rat 4.5 pIC50 = 4.5 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2ccc3cccc(N(C)C)c3c2)c1C 10.1021/jm00004a012
CHEMBL29705 201497 0 None None None Rat 4.5 pIC50 = 4.5 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2ccc3cccc(N(C)C)c3c2)c1C 10.1021/jm00004a012
10645779 197484 0 None None None Human 6.5 pIC50 = 6.5 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 419 4 1 4 4.2 Cc1cc(Br)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
CHEMBL268116 197484 0 None None None Human 6.5 pIC50 = 6.5 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 419 4 1 4 4.2 Cc1cc(Br)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
10832243 468516 0 None None None Human 6.5 pIC50 = 6.5 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 358 5 1 6 2.5 COc1ccc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nn1 10.1021/jm9604585
CHEMBL6624 468516 0 None None None Human 6.5 pIC50 = 6.5 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 358 5 1 6 2.5 COc1ccc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nn1 10.1021/jm9604585
10692649 468152 0 None None None Human 5.5 pIC50 = 5.5 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 404 4 1 3 4.5 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Br)cc3)cccc12 10.1021/jm9604585
CHEMBL6400 468152 0 None None None Human 5.5 pIC50 = 5.5 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 404 4 1 3 4.5 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Br)cc3)cccc12 10.1021/jm9604585
CHEMBL293874 486394 0 None None None Pig 7.5 pIC50 = 7.5 Binding
Binding activity against Endothelin A receptor of Porcine aortic smooth muscle membranesBinding activity against Endothelin A receptor of Porcine aortic smooth muscle membranes
ChEMBL 584 7 6 6 0.3 CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)CN(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00089a028
18738879 181060 0 None None None Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 548 8 2 7 4.8 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)O)cc21 10.1016/s0960-894x(01)00660-6
CHEMBL23833 181060 0 None None None Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 548 8 2 7 4.8 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)O)cc21 10.1016/s0960-894x(01)00660-6
18738879 181060 0 None None None Human 7.5 pIC50 = 7.5 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 548 8 2 7 4.8 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)O)cc21 10.1007/s00044-004-0021-y
CHEMBL23833 181060 0 None None None Human 7.5 pIC50 = 7.5 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 548 8 2 7 4.8 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)O)cc21 10.1007/s00044-004-0021-y
10548486 348179 0 None None None Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 391 5 2 6 3.7 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm9608366
CHEMBL45456 348179 0 None None None Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 391 5 2 6 3.7 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm9608366
44327661 329522 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 483 5 1 8 2.7 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL421563 329522 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 483 5 1 8 2.7 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
44327226 474777 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 497 7 1 8 3.1 CCc1cc(C)nn(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c1=O 10.1016/S0960-894X(96)00617-8
CHEMBL96762 474777 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 497 7 1 8 3.1 CCc1cc(C)nn(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c1=O 10.1016/S0960-894X(96)00617-8
CHEMBL132542 484628 0 None None None Pig 7.5 pIC50 = 7.5 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 584 7 6 6 0.3 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)CN(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10647372 474038 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 454 8 1 6 3.1 CCN(CC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9212 474038 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 454 8 1 6 3.1 CCN(CC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL329609 486726 0 None None None Human 6.5 pIC50 = 6.5 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 922 25 9 8 3.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O)[C@@H](C)CC 10.1021/jm00015a003
10665805 198467 0 None None None Human 6.5 pIC50 = 6.5 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 354 4 1 6 3.0 CCC1=C(c2ccc3c(c2)OCO3)C(=O)OC1(O)c1ccc(OC)cc1 10.1021/jm9606507
CHEMBL273951 198467 0 None None None Human 6.5 pIC50 = 6.5 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 354 4 1 6 3.0 CCC1=C(c2ccc3c(c2)OCO3)C(=O)OC1(O)c1ccc(OC)cc1 10.1021/jm9606507
44298381 392123 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 476 9 2 7 4.9 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCO)c1 10.1016/s0960-894x(00)00366-8
CHEMBL55909 392123 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 476 9 2 7 4.9 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCO)c1 10.1016/s0960-894x(00)00366-8
44279408 214375 0 None None None Pig 5.5 pIC50 = 5.5 Binding
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 521 13 6 4 2.7 CC(C)C[C@H](NC(=O)NCc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31051 214375 0 None None None Pig 5.5 pIC50 = 5.5 Binding
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 521 13 6 4 2.7 CC(C)C[C@H](NC(=O)NCc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
44327868 220946 0 None None None Human 5.5 pIC50 = 5.5 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 906 24 9 8 3.9 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC12CC3CC(CC(C3)C1)C2)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL327523 220946 0 None None None Human 5.5 pIC50 = 5.5 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 906 24 9 8 3.9 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC12CC3CC(CC(C3)C1)C2)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL2369713 485458 0 None None None Human 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cellsInhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cells
ChEMBL 906 22 8 8 3.0 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00152-J
CHEMBL1793934 484839 0 None None None Human 5.5 pIC50 = 5.5 Binding
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 25 8 8 4.5 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm970161m
44327399 317084 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 539 7 1 8 4.2 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)N2N=C(c3cccs3)CCC2=O)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL412865 317084 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 539 7 1 8 4.2 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)N2N=C(c3cccs3)CCC2=O)cc1 10.1016/S0960-894X(96)00617-8
44327734 474947 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 561 8 1 9 3.9 COc1ccc(-c2ccc(=O)n(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)n2)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL97851 474947 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 561 8 1 9 3.9 COc1ccc(-c2ccc(=O)n(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)n2)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL282340 486355 0 None None None Pig 4.5 pIC50 = 4.5 Binding
Binding affinity against ETA receptor in porcine aortic smooth muscle membrane was determinedBinding affinity against ETA receptor in porcine aortic smooth muscle membrane was determined
ChEMBL 531 14 7 6 0.8 CC(C)C[C@H](NC(=O)[C@H](N)C(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(=O)O)C(=O)O 10.1016/0960-894X(95)00221-E
44284506 332710 0 None None None Pig 4.5 pIC50 = 4.5 Binding
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL 596 14 4 4 4.6 CC(C)C[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)N(C)C(=O)[C@@H](CC(C)C)NC(=O)Cc1ccccc1Cl)C(=O)O 10.1021/jm00087a001
CHEMBL431699 332710 0 None None None Pig 4.5 pIC50 = 4.5 Binding
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL 596 14 4 4 4.6 CC(C)C[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)N(C)C(=O)[C@@H](CC(C)C)NC(=O)Cc1ccccc1Cl)C(=O)O 10.1021/jm00087a001
10555806 26393 0 None None None Human 6.5 pIC50 = 6.5 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 616 12 2 7 6.0 CC(C)OCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 10.1021/jm990171i
CHEMBL1184095 26393 0 None None None Human 6.5 pIC50 = 6.5 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 616 12 2 7 6.0 CC(C)OCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 10.1021/jm990171i
23445505 468563 0 None None None Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 412 5 1 7 4.0 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 10.1016/S0960-894X(97)00367-3
CHEMBL66641 468563 0 None None None Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 412 5 1 7 4.0 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 10.1016/S0960-894X(97)00367-3
44314676 202974 0 None None None Pig 7.5 pIC50 = 7.5 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 589 12 5 4 4.6 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1021/jm9600914
CHEMBL306171 202974 0 None None None Pig 7.5 pIC50 = 7.5 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 589 12 5 4 4.6 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C)C(=O)O 10.1021/jm9600914
10577388 39471 0 None None None Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cc(C)ccc2C)cc1 10.1021/jm990170q
CHEMBL122111 39471 0 None None None Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2cc(C)ccc2C)cc1 10.1021/jm990170q
10625270 232423 0 None None None Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(C)cccc2C)cc1 10.1021/jm990170q
CHEMBL331767 232423 0 None None None Human 7.5 pIC50 = 7.5 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(C)cccc2C)cc1 10.1021/jm990170q
70240112 336136 0 None None None Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 626 10 2 11 5.0 CC#CCOc1nc(-c2ccnc(-c3nnn[nH]3)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
CHEMBL4465332 336136 0 None None None Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 626 10 2 11 5.0 CC#CCOc1nc(-c2ccnc(-c3nnn[nH]3)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
44310016 468821 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 489 6 1 9 4.8 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4nsnc4c3)c2cc1OC 10.1016/s0960-894x(97)10151-2
CHEMBL68557 468821 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 489 6 1 9 4.8 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4nsnc4c3)c2cc1OC 10.1016/s0960-894x(97)10151-2
44386143 258586 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 571 9 3 6 5.2 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCc3ccccc32)nc1C(=O)O 10.1021/jm950592+
CHEMBL368360 258586 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 571 9 3 6 5.2 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCc3ccccc32)nc1C(=O)O 10.1021/jm950592+
44310016 468821 0 None None None Human 7.5 pIC50 = 7.5 Binding
Potency at Endothelin A receptor was determinedPotency at Endothelin A receptor was determined
ChEMBL 489 6 1 9 4.8 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4nsnc4c3)c2cc1OC 10.1021/jm0300429
CHEMBL68557 468821 0 None None None Human 7.5 pIC50 = 7.5 Binding
Potency at Endothelin A receptor was determinedPotency at Endothelin A receptor was determined
ChEMBL 489 6 1 9 4.8 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4nsnc4c3)c2cc1OC 10.1021/jm0300429
CHEMBL422285 488433 0 None None None Pig 7.5 pIC50 = 7.5 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 596 7 6 6 0.6 CCC[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44279312 216956 0 None None None Pig 6.5 pIC50 = 6.5 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 565 12 6 4 3.5 CC(C)C[C@H](NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31746 216956 0 None None None Pig 6.5 pIC50 = 6.5 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 565 12 6 4 3.5 CC(C)C[C@H](NC(=O)NC12CC3CC(CC(C3)C1)C2)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
44305079 202187 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 354 4 1 5 3.8 CC(C)Oc1ccc2c(c1)C=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL302189 202187 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 354 4 1 5 3.8 CC(C)Oc1ccc2c(c1)C=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
44293813 365840 0 None None None Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 581 12 2 10 3.9 CCOc1ccc2c(c1)[C@H](c1cc(OC)c(OC)c(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL48261 365840 0 None None None Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 581 12 2 10 3.9 CCOc1ccc2c(c1)[C@H](c1cc(OC)c(OC)c(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
44270523 101866 0 None None None Human 6.5 pIC50 = 6.5 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 724 14 1 9 8.0 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL15573 101866 0 None None None Human 6.5 pIC50 = 6.5 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 724 14 1 9 8.0 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL404763 487834 0 None None None Pig 6.5 pIC50 = 6.5 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 598 7 7 6 0.7 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)C(C)(C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44293716 201541 0 None None None Human 5.5 pIC50 = 5.5 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 433 6 1 6 4.0 COc1ccc([C@@H]2c3cc(OC)ccc3[C@@H](c3ccc4c(c3)OCO4)N2CC(=O)O)cc1 10.1016/s0960-894x(01)00273-6
CHEMBL297353 201541 0 None None None Human 5.5 pIC50 = 5.5 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 433 6 1 6 4.0 COc1ccc([C@@H]2c3cc(OC)ccc3[C@@H](c3ccc4c(c3)OCO4)N2CC(=O)O)cc1 10.1016/s0960-894x(01)00273-6
18936171 393481 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 489 7 1 8 4.2 COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc3c(c2)OCO3)c2c(OC)c(OC)ccc21 10.1016/S0960-894X(97)00319-3
CHEMBL56348 393481 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 489 7 1 8 4.2 COc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc3c(c2)OCO3)c2c(OC)c(OC)ccc21 10.1016/S0960-894X(97)00319-3
44332546 216851 0 None None None Human 4.5 pIC50 = 4.5 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 491 5 0 7 5.7 O=C(OCc1ccc2c(c1)OCO2)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL316648 216851 0 None None None Human 4.5 pIC50 = 4.5 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 491 5 0 7 5.7 O=C(OCc1ccc2c(c1)OCO2)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
44322947 473649 0 None None None Human 6.5 pIC50 = 6.5 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 428 5 1 6 4.3 COc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(96)00496-9
CHEMBL89689 473649 0 None None None Human 6.5 pIC50 = 6.5 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 428 5 1 6 4.3 COc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(96)00496-9
10067069 199686 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 360 4 1 6 3.0 COC(=O)c1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
CHEMBL283195 199686 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 360 4 1 6 3.0 COC(=O)c1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
44385805 124056 0 None None None Human 6.5 pIC50 = 6.5 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 532 10 1 10 4.1 C#CCOc1nc(-c2cnccn2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL176698 124056 0 None None None Human 6.5 pIC50 = 6.5 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 532 10 1 10 4.1 C#CCOc1nc(-c2cnccn2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10230375 257568 0 None None None Human 6.5 pIC50 = 6.5 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 534 9 2 11 2.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ncccn2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL367317 257568 0 None None None Human 6.5 pIC50 = 6.5 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 534 9 2 11 2.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ncccn2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
44384557 259274 0 None None None Human 6.5 pIC50 = 6.5 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 504 9 1 10 3.3 C#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL369003 259274 0 None None None Human 6.5 pIC50 = 6.5 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 504 9 1 10 3.3 C#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
23445547 221828 0 None None None Human 5.5 pIC50 = 5.5 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 398 4 1 5 4.3 Cc1noc(NS(=O)(=O)c2cc(-c3ccccc3)cs2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL329375 221828 0 None None None Human 5.5 pIC50 = 5.5 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 398 4 1 5 4.3 Cc1noc(NS(=O)(=O)c2cc(-c3ccccc3)cs2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL303204 486416 0 None None None Pig 7.5 pIC50 = 7.5 Binding
Binding activity against Endothelin A receptor of Porcine aortic smooth muscle membranesBinding activity against Endothelin A receptor of Porcine aortic smooth muscle membranes
ChEMBL 598 7 6 6 0.7 CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00089a028
22467219 176294 0 None None None Human 7.5 pIC50 = 7.5 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 492 6 2 7 3.3 Cc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(CO)ccc23)cc1 10.1007/s00044-004-0021-y
CHEMBL2261362 176294 0 None None None Human 7.5 pIC50 = 7.5 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 492 6 2 7 3.3 Cc1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(CO)ccc23)cc1 10.1007/s00044-004-0021-y
44320461 216025 0 None None None Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 514 6 1 5 6.6 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00513-8
CHEMBL313920 216025 0 None None None Rat 7.5 pIC50 = 7.5 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 514 6 1 5 6.6 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00513-8
10457385 222165 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 469 6 1 8 2.5 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
155511294 222165 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 469 6 1 8 2.5 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL330424 222165 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 469 6 1 8 2.5 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL4435789 222165 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 469 6 1 8 2.5 Cc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL263537 486087 0 None None None Pig 7.5 pIC50 = 7.5 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 598 7 6 6 0.7 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10670664 474219 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 438 8 2 6 2.6 C=CCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9342 474219 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 438 8 2 6 2.6 C=CCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10792636 333192 0 None None None Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 544 10 2 6 5.4 CCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(CC)cccc2CC)cc1 10.1021/jm990170q
CHEMBL435385 333192 0 None None None Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 544 10 2 6 5.4 CCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(CC)cccc2CC)cc1 10.1021/jm990170q
44327423 474428 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 483 6 1 8 2.8 Cc1cc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)nc1C 10.1016/S0960-894X(96)00617-8
CHEMBL94720 474428 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 483 6 1 8 2.8 Cc1cc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)nc1C 10.1016/S0960-894X(96)00617-8
9998563 197171 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc(S(=O)(=O)Nc2onc(C)c2C)c2ccccc12 10.1021/jm00008a013
CHEMBL26527 197171 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc(S(=O)(=O)Nc2onc(C)c2C)c2ccccc12 10.1021/jm00008a013
10895198 201094 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 9 1 6 5.0 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2cccc(OCCC)c21 10.1021/jm010382z
CHEMBL294123 201094 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 426 9 1 6 5.0 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2cccc(OCCC)c21 10.1021/jm010382z
44298612 390436 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 281 4 2 5 1.9 CCc1c(NS(=O)(=O)c2ccc(N)cc2)noc1C 10.1016/s0960-894x(00)00366-8
CHEMBL55405 390436 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 281 4 2 5 1.9 CCc1c(NS(=O)(=O)c2ccc(N)cc2)noc1C 10.1016/s0960-894x(00)00366-8
9998563 197171 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc(S(=O)(=O)Nc2onc(C)c2C)c2ccccc12 10.1021/jm00004a012
CHEMBL26527 197171 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc(S(=O)(=O)Nc2onc(C)c2C)c2ccccc12 10.1021/jm00004a012
44332638 18724 0 None None None Human 4.5 pIC50 = 4.5 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 477 6 0 6 6.0 COc1ccc(COC(=O)C(c2ccc3c(c2)OCO3)c2c3ccccc3nc3ccccc23)cc1 10.1016/S0960-894X(96)00551-3
CHEMBL101239 18724 0 None None None Human 4.5 pIC50 = 4.5 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 477 6 0 6 6.0 COc1ccc(COC(=O)C(c2ccc3c(c2)OCO3)c2c3ccccc3nc3ccccc23)cc1 10.1016/S0960-894X(96)00551-3
137643691 314136 0 None None None Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 569 10 2 7 5.5 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CCC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4088634 314136 0 None None None Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 569 10 2 7 5.5 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC4CCC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
23445538 122847 0 None None None Human 6.5 pIC50 = 6.5 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 456 6 1 6 4.8 Cc1ccc(OCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00132-7
CHEMBL173805 122847 0 None None None Human 6.5 pIC50 = 6.5 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 456 6 1 6 4.8 Cc1ccc(OCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00132-7
23445272 255694 0 None None None Human 6.5 pIC50 = 6.5 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 440 6 1 5 4.7 Cc1ccc(CCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00133-9
CHEMBL366364 255694 0 None None None Human 6.5 pIC50 = 6.5 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 440 6 1 5 4.7 Cc1ccc(CCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00133-9
10615322 468434 0 None None None Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 316 4 1 7 1.9 COC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C 10.1016/S0960-894X(97)00367-3
CHEMBL65639 468434 0 None None None Human 5.5 pIC50 = 5.5 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 316 4 1 7 1.9 COC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1C 10.1016/S0960-894X(97)00367-3
11762081 468347 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 7 1 5 5.5 COc1ccc(C2=C(C(=O)O)C(c3ccc(OC)cc3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm031041j
CHEMBL64851 468347 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 7 1 5 5.5 COc1ccc(C2=C(C(=O)O)C(c3ccc(OC)cc3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm031041j
CHEMBL307324 486455 0 None None None Pig 7.5 pIC50 = 7.5 Binding
Binding activity against Endothelin A receptor of Porcine aortic smooth muscle membranesBinding activity against Endothelin A receptor of Porcine aortic smooth muscle membranes
ChEMBL 624 7 5 6 1.2 CC(C)C[C@H]1C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CC(=O)O)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C(C)C)C(=O)N1C 10.1021/jm00089a028
CHEMBL319719 486630 0 None None None Human 7.5 pIC50 = 7.5 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 879 23 8 7 4.7 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10503067 22486 0 None None None Human 7.5 pIC50 = 7.5 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 436 5 1 6 4.9 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2CC2CCCCCC2)cc1 10.1021/jm9606507
CHEMBL10919 22486 0 None None None Human 7.5 pIC50 = 7.5 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 436 5 1 6 4.9 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2CC2CCCCCC2)cc1 10.1021/jm9606507
11762081 468347 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 446 7 1 5 5.5 COc1ccc(C2=C(C(=O)O)C(c3ccc(OC)cc3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL64851 468347 0 None None None Rat 7.5 pIC50 = 7.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 446 7 1 5 5.5 COc1ccc(C2=C(C(=O)O)C(c3ccc(OC)cc3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
155519245 334898 0 None None None Human 7.5 pIC50 = 7.5 Binding
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 592 10 2 10 4.2 COc1ccc(Cl)c(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)nc(N3CCOCC3)nc2OCCO)c1 10.1016/j.bmcl.2016.06.014
CHEMBL4447261 334898 0 None None None Human 7.5 pIC50 = 7.5 Binding
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 592 10 2 10 4.2 COc1ccc(Cl)c(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)nc(N3CCOCC3)nc2OCCO)c1 10.1016/j.bmcl.2016.06.014
22467240 199407 0 None None None Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 558 7 2 9 3.8 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(-c4nn[nH]n4)ccc23)cc1 10.1016/s0960-894x(01)00660-6
CHEMBL281378 199407 0 None None None Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 558 7 2 9 3.8 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(-c4nn[nH]n4)ccc23)cc1 10.1016/s0960-894x(01)00660-6
10305334 256980 0 None None None Human 7.5 pIC50 = 7.5 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 680 12 2 11 6.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
CHEMBL367036 256980 0 None None None Human 7.5 pIC50 = 7.5 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 680 12 2 11 6.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccc1 10.1016/s0960-894x(02)01084-3
CHEMBL138120 484673 0 None None None Pig 7.5 pIC50 = 7.5 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 624 7 5 6 1.2 CC(C)C[C@@H]1C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CC(=O)O)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](C(C)C)C(=O)N1C 10.1021/jm00021a021
11133491 202261 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 416 3 1 6 4.2 O=C(O)C1=C(c2ccc3c(c2)OCO3)c2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm010382z
CHEMBL302659 202261 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 416 3 1 6 4.2 O=C(O)C1=C(c2ccc3c(c2)OCO3)c2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm010382z
10950843 468010 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 8 1 6 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1cccc(OC)c1)O2 10.1021/jm010382z
CHEMBL62951 468010 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 8 1 6 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1cccc(OC)c1)O2 10.1021/jm010382z
44279370 216846 0 None None None Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 426 4 2 3 4.7 CCc1ccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)cc1 10.1016/0960-894X(95)00230-Q
CHEMBL31662 216846 0 None None None Human 6.5 pIC50 = 6.5 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 426 4 2 3 4.7 CCc1ccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)cc1 10.1016/0960-894X(95)00230-Q
CHEMBL1790451 484799 0 None None None Pig 6.5 pIC50 = 6.5 Binding
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL 865 19 9 8 2.4 CC(=O)N[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(C)C)[C@H](C)O)C1c2ccccc2CCc2ccccc21 10.1016/0960-894X(95)00349-X
10790376 331719 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 466 6 1 6 3.3 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N2CCCCC2)cc1 10.1021/jm9505369
CHEMBL428644 331719 0 None None None Rat 6.5 pIC50 = 6.5 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 466 6 1 6 3.3 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N2CCCCC2)cc1 10.1021/jm9505369
44266655 19382 0 None None None Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 445 5 1 7 4.5 COc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL10523 19382 0 None None None Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 445 5 1 7 4.5 COc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
44371420 104145 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 485 7 1 7 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cccc(OC)c3OC)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL157763 104145 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 485 7 1 7 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3cccc(OC)c3OC)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
10425958 200133 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc(N)c3ccccc23)c1C 10.1021/jm00008a013
CHEMBL286406 200133 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc(N)c3ccccc23)c1C 10.1021/jm00008a013
CHEMBL438194 488699 13 None None None Human 5.5 pIC50 = 5.5 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 923 25 9 8 4.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
44327881 317212 0 None None None Human 5.5 pIC50 = 5.5 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 1044 26 9 8 6.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL413179 317212 0 None None None Human 5.5 pIC50 = 5.5 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 1044 26 9 8 6.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C12CC3CC(CC(C3)C1)C2)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
44298613 390438 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 287 3 2 5 2.0 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1Cl 10.1016/s0960-894x(00)00366-8
CHEMBL55406 390438 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 287 3 2 5 2.0 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1Cl 10.1016/s0960-894x(00)00366-8
CHEMBL438768 488741 0 None None None Rat 5.5 pIC50 = 5.5 Binding
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1868 40 24 25 -1.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
44277387 216509 0 None None None Rat 5.5 pIC50 = 5.5 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 450 7 2 6 3.0 O=C(O)COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144800 216509 0 None None None Rat 5.5 pIC50 = 5.5 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 450 7 2 6 3.0 O=C(O)COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
10425958 200133 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc(N)c3ccccc23)c1C 10.1021/jm00004a012
CHEMBL286406 200133 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc(N)c3ccccc23)c1C 10.1021/jm00004a012
44266645 474629 0 None None None Human 5.5 pIC50 = 5.5 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 417 5 1 6 4.7 COc1ccc(-n2c(C(=O)O)c(-c3ccc4c(c3)OCO4)c3cc(OC)ccc32)cc1 10.1016/0960-894X(96)00170-9
CHEMBL9588 474629 0 None None None Human 5.5 pIC50 = 5.5 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 417 5 1 6 4.7 COc1ccc(-n2c(C(=O)O)c(-c3ccc4c(c3)OCO4)c3cc(OC)ccc32)cc1 10.1016/0960-894X(96)00170-9
127034918 273897 0 None None None Human 4.5 pIC50 = 4.5 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 599 11 2 7 6.6 CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 10.1039/C4MD00499J
CHEMBL3735797 273897 0 None None None Human 4.5 pIC50 = 4.5 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 599 11 2 7 6.6 CCCNC(=O)c1cc(C)c2nc(CCC)n(Cc3ccc(-c4ccccc4S(=O)(=O)Nc4onc(C)c4C)cc3)c2c1 10.1039/C4MD00499J
CHEMBL263025 486072 0 None None None Pig 4.5 pIC50 = 4.5 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 558 7 8 7 -1.7 CC(C)C[C@H]1NC(=O)CNC(=O)[C@@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44386523 260446 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 621 10 4 6 5.5 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2c(F)c(F)c(F)c(F)c2F)nc1C(=O)O 10.1021/jm950592+
CHEMBL369874 260446 0 None None None Rat 5.5 pIC50 = 5.5 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 621 10 4 6 5.5 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2c(F)c(F)c(F)c(F)c2F)nc1C(=O)O 10.1021/jm950592+
CHEMBL421190 488430 0 None None None Human 7.4 pIC50 = 7.4 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 879 24 8 7 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL2304009 485311 0 None None None Pig 7.4 pIC50 = 7.4 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 674 6 6 6 1.2 CC(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Br)[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC1=O 10.1021/jm9600914
CHEMBL87243 489397 0 None None None Human 5.4 pIC50 = 5.4 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 805 22 9 8 1.6 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00070a001
44327347 197090 0 None None None Human 5.4 pIC50 = 5.4 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 1102 26 9 8 7.1 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C1c2ccccc2CCc2ccccc21)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL264579 197090 0 None None None Human 5.4 pIC50 = 5.4 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 1102 26 9 8 7.1 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C1c2ccccc2CCc2ccccc21)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
44368516 98097 0 None None None Pig 4.4 pIC50 = 4.4 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 451 11 2 6 4.1 COc1ccc(CN(Cc2cc(OC)cc(OC)c2)C(Cc2ccc(O)cc2)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
CHEMBL152203 98097 0 None None None Pig 4.4 pIC50 = 4.4 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 451 11 2 6 4.1 COc1ccc(CN(Cc2cc(OC)cc(OC)c2)C(Cc2ccc(O)cc2)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
10816835 124145 0 None None None Rat 4.4 pIC50 = 4.4 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 567 11 4 5 5.7 CCCc1sc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
CHEMBL176992 124145 0 None None None Rat 4.4 pIC50 = 4.4 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 567 11 4 5 5.7 CCCc1sc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
137652304 313132 0 None None None Human 6.4 pIC50 = 6.4 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 544 10 3 8 3.7 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCCN)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4076290 313132 0 None None None Human 6.4 pIC50 = 6.4 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 544 10 3 8 3.7 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCCN)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
22998446 216296 0 None None None Human 4.4 pIC50 = 4.4 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 398 4 1 5 4.3 Cc1noc(NS(=O)(=O)c2ccc(-c3ccccc3)s2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL314320 216296 0 None None None Human 4.4 pIC50 = 4.4 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 398 4 1 5 4.3 Cc1noc(NS(=O)(=O)c2ccc(-c3ccccc3)s2)c1Br 10.1016/S0960-894X(96)00496-9
101039204 1466 45 None None None Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at Homo sapiens (human) ETA receptorAntagonist activity at Homo sapiens (human) ETA receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1007/s00044-013-0542-3
443289 1466 45 None None None Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at Homo sapiens (human) ETA receptorAntagonist activity at Homo sapiens (human) ETA receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1007/s00044-013-0542-3
997 1466 45 None None None Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at Homo sapiens (human) ETA receptorAntagonist activity at Homo sapiens (human) ETA receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1007/s00044-013-0542-3
CHEMBL314691 1466 45 None None None Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at Homo sapiens (human) ETA receptorAntagonist activity at Homo sapiens (human) ETA receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1007/s00044-013-0542-3
CHEMBL4095638 1466 45 None None None Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at Homo sapiens (human) ETA receptorAntagonist activity at Homo sapiens (human) ETA receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1007/s00044-013-0542-3
DB12054 1466 45 None None None Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at Homo sapiens (human) ETA receptorAntagonist activity at Homo sapiens (human) ETA receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1007/s00044-013-0542-3
11798762 473575 0 None None None Rat 7.4 pIC50 = 7.4 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 475 9 1 7 3.1 CCCS(=O)(=O)CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL8911 473575 0 None None None Rat 7.4 pIC50 = 7.4 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 475 9 1 7 3.1 CCCS(=O)(=O)CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10768346 259425 0 None None None Rat 7.4 pIC50 = 7.4 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 522 10 5 5 4.0 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL369202 259425 0 None None None Rat 7.4 pIC50 = 7.4 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 522 10 5 5 4.0 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCC2)nc1C(=O)O 10.1021/jm950592+
24997097 42333 3 None None None Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 501 7 3 7 4.0 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(O)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL1272137 42333 3 None None None Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 501 7 3 7 4.0 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(O)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
44309445 202759 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 370 4 1 5 3.4 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc4c(c3)OCO4)cccc12 10.1016/s0960-894x(97)10151-2
CHEMBL304761 202759 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 370 4 1 5 3.4 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc4c(c3)OCO4)cccc12 10.1016/s0960-894x(97)10151-2
10816963 232378 0 None None None Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 574 12 2 7 5.0 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC)cc1 10.1021/jm990170q
CHEMBL331625 232378 0 None None None Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 574 12 2 7 5.0 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC)cc1 10.1021/jm990170q
CHEMBL289687 486377 0 None None None Rat 5.4 pIC50 = 5.4 Binding
Compound was evaluated for the binding affinity to endothelin receptor in the rat heart ventricle.Compound was evaluated for the binding affinity to endothelin receptor in the rat heart ventricle.
ChEMBL 837 24 10 9 1.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00087a001
10602726 330652 0 None None None Rat 5.4 pIC50 = 5.4 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 549 10 4 5 5.1 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C2CC2)o1 10.1021/jm950591h
CHEMBL424764 330652 0 None None None Rat 5.4 pIC50 = 5.4 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 549 10 4 5 5.1 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C2CC2)o1 10.1021/jm950591h
44332623 19106 0 None None None Human 4.4 pIC50 = 4.4 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 320 3 1 4 2.9 Cc1cc(C(C(N)=O)c2ccc3c(c2)OCO3)c2ccccc2n1 10.1016/S0960-894X(96)00551-3
CHEMBL103886 19106 0 None None None Human 4.4 pIC50 = 4.4 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 320 3 1 4 2.9 Cc1cc(C(C(N)=O)c2ccc3c(c2)OCO3)c2ccccc2n1 10.1016/S0960-894X(96)00551-3
137655285 314832 0 None None None Human 6.4 pIC50 = 6.4 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 568 10 3 10 3.1 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCCN)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4096211 314832 0 None None None Human 6.4 pIC50 = 6.4 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 568 10 3 10 3.1 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCCN)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
44177614 257570 0 None None None Human 6.4 pIC50 = 6.4 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 547 10 1 9 5.4 C=CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL367339 257570 0 None None None Human 6.4 pIC50 = 6.4 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 547 10 1 9 5.4 C=CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
22467229 199192 0 None None None Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 519 7 2 7 4.1 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(CN)ccc23)cc1 10.1016/s0960-894x(01)00660-6
CHEMBL279703 199192 0 None None None Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 519 7 2 7 4.1 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(CN)ccc23)cc1 10.1016/s0960-894x(01)00660-6
44385008 259249 0 None None None Human 7.4 pIC50 = 7.4 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 574 10 2 9 4.9 C#CCOc1nc(-c2ccnc(CO)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL368829 259249 0 None None None Human 7.4 pIC50 = 7.4 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 574 10 2 9 4.9 C#CCOc1nc(-c2ccnc(CO)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
19010493 198630 0 None None None Human 7.4 pIC50 = 7.4 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 543 11 1 7 6.5 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL275179 198630 0 None None None Human 7.4 pIC50 = 7.4 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 543 11 1 7 6.5 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)O)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
42630532 42259 0 None None None Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 541 10 2 7 4.9 C=CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL1271479 42259 0 None None None Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 541 10 2 7 4.9 C=CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
42630532 42259 0 None None None Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 541 10 2 7 4.9 C=CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1271479 42259 0 None None None Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 541 10 2 7 4.9 C=CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2010.08.074
24997097 42333 3 None None None Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 501 7 3 7 4.0 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(O)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1272137 42333 3 None None None Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 501 7 3 7 4.0 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(O)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
10173807 104117 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 455 6 1 6 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL157742 104117 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 455 6 1 6 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
18995990 199564 0 None None None Human 6.4 pIC50 = 6.4 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 507 7 1 9 5.0 COc1cccc(Sc2c(C(=O)O)n(Cc3cc(OC)c4c(c3)OCO4)c3cc4c(cc23)OCO4)c1 10.1016/0960-894X(96)00232-6
CHEMBL282426 199564 0 None None None Human 6.4 pIC50 = 6.4 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 507 7 1 9 5.0 COc1cccc(Sc2c(C(=O)O)n(Cc3cc(OC)c4c(c3)OCO4)c3cc4c(cc23)OCO4)c1 10.1016/0960-894X(96)00232-6
10160887 200321 0 None None None Human 6.4 pIC50 = 6.4 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 447 5 1 7 5.0 O=C(O)c1c(Sc2ccc3c(c2)OCO3)c2ccccc2n1Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00232-6
CHEMBL28779 200321 0 None None None Human 6.4 pIC50 = 6.4 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 447 5 1 7 5.0 O=C(O)c1c(Sc2ccc3c(c2)OCO3)c2ccccc2n1Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00232-6
CHEMBL411797 488186 0 None None None Human 6.4 pIC50 = 6.4 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 957 25 9 8 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
44298277 389542 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 474 9 1 7 5.1 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCC=O)c1 10.1016/s0960-894x(00)00366-8
CHEMBL54773 389542 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 474 9 1 7 5.1 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCC=O)c1 10.1016/s0960-894x(00)00366-8
10288713 202143 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 473 7 1 7 4.6 CCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)c(=O)n2Cc1ccccc1OC 10.1016/S0960-894X(97)00319-3
CHEMBL301840 202143 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)Inhibition of [125I]ET1 binding to rat aorta membranes(ETA)
ChEMBL 473 7 1 7 4.6 CCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)c(=O)n2Cc1ccccc1OC 10.1016/S0960-894X(97)00319-3
CHEMBL62514 489348 0 None None None Pig 6.4 pIC50 = 6.4 Binding
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL 851 19 9 8 2.0 CC(=O)N[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(C)C)C1c2ccccc2CCc2ccccc21 10.1016/0960-894X(95)00349-X
10383832 332903 0 None None None Rat 5.4 pIC50 = 5.4 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2cc(S(=O)(=O)Nc3onc(C)c3C)ccc2c1 10.1021/jm00008a013
CHEMBL433234 332903 0 None None None Rat 5.4 pIC50 = 5.4 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2cc(S(=O)(=O)Nc3onc(C)c3C)ccc2c1 10.1021/jm00008a013
10540843 176756 6 None None None Human 5.4 pIC50 = 5.4 Binding
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 282 4 1 3 4.0 Cc1c(C(=O)O)oc2cccc(OCc3ccccc3)c12 10.1007/s00044-013-0542-3
CHEMBL2296889 176756 6 None None None Human 5.4 pIC50 = 5.4 Binding
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 282 4 1 3 4.0 Cc1c(C(=O)O)oc2cccc(OCc3ccccc3)c12 10.1007/s00044-013-0542-3
CHEMBL408141 488004 0 None None None Human 5.4 pIC50 = 5.4 Binding
Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)
ChEMBL 1496 31 18 19 0.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
18617407 469848 0 None None None Human 5.4 pIC50 = 5.4 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 320 3 1 4 3.4 Cc1noc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL76576 469848 0 None None None Human 5.4 pIC50 = 5.4 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 320 3 1 4 3.4 Cc1noc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1C 10.1016/0960-894X(96)00441-6
44276886 216492 0 None None None Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 410 4 1 4 4.2 O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1ccccc1Cl 10.1016/s0960-894x(00)00232-8
CHEMBL3144600 216492 0 None None None Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 410 4 1 4 4.2 O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1ccccc1Cl 10.1016/s0960-894x(00)00232-8
44277368 216504 0 None None None Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 480 8 2 7 3.0 COc1ccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c(OCC(=O)O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144733 216504 0 None None None Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 480 8 2 7 3.0 COc1ccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2=O)c(OCC(=O)O)c1 10.1016/s0960-894x(00)00232-8
10070783 197378 0 None None None Human 5.4 pIC50 = 5.4 Binding
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 420 4 1 5 4.5 O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
CHEMBL267094 197378 0 None None None Human 5.4 pIC50 = 5.4 Binding
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 420 4 1 5 4.5 O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
10383832 332903 0 None None None Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2cc(S(=O)(=O)Nc3onc(C)c3C)ccc2c1 10.1021/jm00004a012
CHEMBL433234 332903 0 None None None Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2cc(S(=O)(=O)Nc3onc(C)c3C)ccc2c1 10.1021/jm00004a012
44368482 97970 0 None None None Pig 4.4 pIC50 = 4.4 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 523 8 2 7 4.2 O=C(O)C(Cc1ccc(O)cc1)N(Cc1cc2c(cc1Cl)OCO2)C(=O)/C=C/c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00009-9
CHEMBL152091 97970 0 None None None Pig 4.4 pIC50 = 4.4 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 523 8 2 7 4.2 O=C(O)C(Cc1ccc(O)cc1)N(Cc1cc2c(cc1Cl)OCO2)C(=O)/C=C/c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00009-9
4550514 197518 4 None None None Rat 4.4 pIC50 = 4.4 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 386 5 3 5 3.7 Cc1noc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccccc3)cc2)c1C 10.1021/jm00008a013
CHEMBL26842 197518 4 None None None Rat 4.4 pIC50 = 4.4 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 386 5 3 5 3.7 Cc1noc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccccc3)cc2)c1C 10.1021/jm00008a013
127035083 273803 0 None None None Human 6.4 pIC50 = 6.4 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 677 12 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3734835 273803 0 None None None Human 6.4 pIC50 = 6.4 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 677 12 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCc3ccc(OC)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
76320429 176758 0 None None None Rat 7.4 pIC50 = 7.4 Binding
Displacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hrDisplacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hr
ChEMBL 324 4 1 6 3.6 Cc1c(C(=O)O)oc2cccc(OCc3ccc4nonc4c3)c12 10.1007/s00044-013-0542-3
CHEMBL2296900 176758 0 None None None Rat 7.4 pIC50 = 7.4 Binding
Displacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hrDisplacement of [125I]ET-1 from ETA receptor in Sprague-Dawley Rattus norvegicus (rat) myocardium after 1 hr
ChEMBL 324 4 1 6 3.6 Cc1c(C(=O)O)oc2cccc(OCc3ccc4nonc4c3)c12 10.1007/s00044-013-0542-3
10875450 24127 0 None None None Pig 7.4 pIC50 = 7.4 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 565 11 1 10 4.9 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2nccc(C)n2)c1 10.1021/jm0102304
CHEMBL113927 24127 0 None None None Pig 7.4 pIC50 = 7.4 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 565 11 1 10 4.9 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2nccc(C)n2)c1 10.1021/jm0102304
18704814 200297 0 None None None Human 7.4 pIC50 = 7.4 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 475 7 1 5 4.9 COc1nc(Br)cnc1NS(=O)(=O)c1ccccc1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
CHEMBL287581 200297 0 None None None Human 7.4 pIC50 = 7.4 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 475 7 1 5 4.9 COc1nc(Br)cnc1NS(=O)(=O)c1ccccc1-c1ccc(CC(C)C)cc1 10.1016/S0960-894X(97)00228-X
44279173 216899 0 None None None Human 7.4 pIC50 = 7.4 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 476 6 2 6 3.1 CNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccccc1 10.1016/S0960-894X(97)00228-X
CHEMBL31696 216899 0 None None None Human 7.4 pIC50 = 7.4 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 476 6 2 6 3.1 CNC(=O)c1cccc(S(=O)(=O)Nc2ncc(Br)nc2OC)c1-c1ccccc1 10.1016/S0960-894X(97)00228-X
44279237 220062 0 None None None Human 7.4 pIC50 = 7.4 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 462 6 2 6 2.8 COc1nc(Br)cnc1NS(=O)(=O)c1cccc(C(N)=O)c1-c1ccccc1 10.1016/S0960-894X(97)00228-X
CHEMBL32512 220062 0 None None None Human 7.4 pIC50 = 7.4 Binding
In vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptorsIn vitro binding was measured by the displacement of [125I]ET1 from membranes prepared from MEL cells transfected with cloned human ETA receptors
ChEMBL 462 6 2 6 2.8 COc1nc(Br)cnc1NS(=O)(=O)c1cccc(C(N)=O)c1-c1ccccc1 10.1016/S0960-894X(97)00228-X
44309996 468748 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 483 5 1 8 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccc4nsnc4c3)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(97)10151-2
CHEMBL67971 468748 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 483 5 1 8 5.2 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccc4nsnc4c3)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(97)10151-2
CHEMBL342913 487087 0 None None None Pig 6.4 pIC50 = 6.4 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 624 7 5 7 0.9 COC(=O)C[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C1=O 10.1021/jm00021a021
44279300 216201 0 None None None Pig 5.4 pIC50 = 5.4 Binding
Binding affinity against ETA receptor in porcine aortic smooth muscle membrane was determinedBinding affinity against ETA receptor in porcine aortic smooth muscle membrane was determined
ChEMBL 472 13 5 4 2.4 CC(C)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31405 216201 0 None None None Pig 5.4 pIC50 = 5.4 Binding
Binding affinity against ETA receptor in porcine aortic smooth muscle membrane was determinedBinding affinity against ETA receptor in porcine aortic smooth muscle membrane was determined
ChEMBL 472 13 5 4 2.4 CC(C)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
44279350 332900 0 None None None Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 428 4 2 4 4.2 COc1cccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)c1 10.1016/0960-894X(95)00230-Q
CHEMBL433229 332900 0 None None None Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 428 4 2 4 4.2 COc1cccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)c1 10.1016/0960-894X(95)00230-Q
10390467 197446 0 None None None Rat 4.4 pIC50 = 4.4 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 481 6 1 5 6.4 Cc1noc(NS(=O)(=O)c2cccc3c(N=C(c4ccccc4)c4ccccc4)cccc23)c1C 10.1021/jm00008a013
CHEMBL26776 197446 0 None None None Rat 4.4 pIC50 = 4.4 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 481 6 1 5 6.4 Cc1noc(NS(=O)(=O)c2cccc3c(N=C(c4ccccc4)c4ccccc4)cccc23)c1C 10.1021/jm00008a013
10373814 38798 0 None None None Pig 4.4 pIC50 = 4.4 Binding
Displacement of [125]ET1 from ETA receptor in pig thoracic aortaDisplacement of [125]ET1 from ETA receptor in pig thoracic aorta
ChEMBL 1016 2 6 12 7.0 O=C1NCCc2ccc(c(Br)c2)Oc2cc(ccc2O)CCNC(=O)/C(=N/O)Cc2cc(Br)c(OS(=O)(=O)O)c(c2)Oc2c(Br)cc(cc2Br)C/C1=N\O 10.1021/np50099a026
CHEMBL1207961 38798 0 None None None Pig 4.4 pIC50 = 4.4 Binding
Displacement of [125]ET1 from ETA receptor in pig thoracic aortaDisplacement of [125]ET1 from ETA receptor in pig thoracic aorta
ChEMBL 1016 2 6 12 7.0 O=C1NCCc2ccc(c(Br)c2)Oc2cc(ccc2O)CCNC(=O)/C(=N/O)Cc2cc(Br)c(OS(=O)(=O)O)c(c2)Oc2c(Br)cc(cc2Br)C/C1=N\O 10.1021/np50099a026
10793886 122596 0 None None None Rat 4.4 pIC50 = 4.4 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 615 11 4 5 6.3 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(Cc2ccccc2)s1 10.1021/jm950591h
CHEMBL172760 122596 0 None None None Rat 4.4 pIC50 = 4.4 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 615 11 4 5 6.3 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(Cc2ccccc2)s1 10.1021/jm950591h
10625083 473596 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 496 10 1 5 5.3 CCCCN(CCCC)C(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL8925 473596 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 496 10 1 5 5.3 CCCCN(CCCC)C(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10833400 317403 0 None None None Human 6.4 pIC50 = 6.4 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 376 4 1 5 3.5 Cc1cc(Cl)nnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
CHEMBL415106 317403 0 None None None Human 6.4 pIC50 = 6.4 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 376 4 1 5 3.5 Cc1cc(Cl)nnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
11793650 197634 0 None None None Human 5.4 pIC50 = 5.4 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 372 6 1 6 2.9 CCOc1ccc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nn1 10.1021/jm9604585
CHEMBL269237 197634 0 None None None Human 5.4 pIC50 = 5.4 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 372 6 1 6 2.9 CCOc1ccc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nn1 10.1021/jm9604585
25211074 42345 0 None None None Human 8.4 pIC50 = 8.4 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in membranes by radioligand assayAntagonist activity at ETA receptor (unknown origin) expressed in membranes by radioligand assay
ChEMBL 543 10 2 7 5.1 CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL1272244 42345 0 None None None Human 8.4 pIC50 = 8.4 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in membranes by radioligand assayAntagonist activity at ETA receptor (unknown origin) expressed in membranes by radioligand assay
ChEMBL 543 10 2 7 5.1 CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL405599 487870 0 None None None Human 8.4 pIC50 = 8.4 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 966 27 12 9 2.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10767505 19636 0 None None None Human 8.4 pIC50 = 8.4 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 494 6 1 8 3.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(S(C)(=O)=O)cc2)cc1 10.1021/jm9606507
CHEMBL10661 19636 0 None None None Human 8.4 pIC50 = 8.4 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 494 6 1 8 3.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(S(C)(=O)=O)cc2)cc1 10.1021/jm9606507
10673715 23855 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 528 14 1 5 5.4 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCCC(F)(F)F 10.1021/jm980217s
CHEMBL112314 23855 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 528 14 1 5 5.4 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCCC(F)(F)F 10.1021/jm980217s
10650210 202843 0 None None None Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 545 9 1 9 3.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCN3CCOCC3)c2)cc1 10.1021/jm980504w
CHEMBL305267 202843 0 None None None Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 545 9 1 9 3.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(OCCN3CCOCC3)c2)cc1 10.1021/jm980504w
10361993 199765 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 373 5 1 5 4.1 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C(C)C)cccc23)c1C 10.1021/jm00004a012
CHEMBL283652 199765 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 373 5 1 5 4.1 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C(C)C)cccc23)c1C 10.1021/jm00004a012
44304492 196896 0 None None None Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 949 23 9 8 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm970161m
CHEMBL262993 196896 0 None None None Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 949 23 9 8 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm970161m
CHEMBL133257 484639 0 None None None Pig 8.4 pIC50 = 8.4 Binding
Inhibitory effect against porcine ET-A receptorInhibitory effect against porcine ET-A receptor
ChEMBL 636 7 6 6 1.4 CC(C)C[C@H]1NC(=O)[C@H](C2CCCC2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44311232 469050 0 None None None Human 8.4 pIC50 = 8.4 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 658 13 2 13 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70293 469050 0 None None None Human 8.4 pIC50 = 8.4 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 658 13 2 13 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44311233 469052 0 None None None Human 8.4 pIC50 = 8.4 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 630 12 2 13 4.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70303 469052 0 None None None Human 8.4 pIC50 = 8.4 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 630 12 2 13 4.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL133257 484639 0 None None None Pig 8.4 pIC50 = 8.4 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 636 7 6 6 1.4 CC(C)C[C@H]1NC(=O)[C@H](C2CCCC2)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10961277 201155 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 446 5 2 6 4.9 CC(C)Oc1ccc2c(c1)C(c1ccc(O)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL294496 201155 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 446 5 2 6 4.9 CC(C)Oc1ccc2c(c1)C(c1ccc(O)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
10391968 365909 0 None None None Human 8.4 pIC50 = 8.4 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 521 10 2 8 3.9 CCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL50232 365909 0 None None None Human 8.4 pIC50 = 8.4 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 521 10 2 8 3.9 CCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
25211074 42345 0 None None None Human 8.4 pIC50 = 8.4 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 543 10 2 7 5.1 CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL1272244 42345 0 None None None Human 8.4 pIC50 = 8.4 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 543 10 2 7 5.1 CCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
11058717 467896 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 412 8 1 6 4.6 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OCC)cc21 10.1021/jm010382z
CHEMBL62348 467896 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 412 8 1 6 4.6 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OCC)cc21 10.1021/jm010382z
22009947 176292 0 None None None Human 8.4 pIC50 = 8.4 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 536 7 2 8 3.6 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 10.1007/s00044-004-0021-y
9807200 176292 0 None None None Human 8.4 pIC50 = 8.4 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 536 7 2 8 3.6 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261358 176292 0 None None None Human 8.4 pIC50 = 8.4 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 536 7 2 8 3.6 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261359 176292 0 None None None Human 8.4 pIC50 = 8.4 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 536 7 2 8 3.6 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 10.1007/s00044-004-0021-y
71451528 163118 0 None None None Human 8.4 pIC50 = 8.4 Binding
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 631 14 1 12 4.3 CCCCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
CHEMBL2163715 163118 0 None None None Human 8.4 pIC50 = 8.4 Binding
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 631 14 1 12 4.3 CCCCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
21041249 163091 0 None None None Human 8.4 pIC50 = 8.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 648 11 1 8 4.7 CN(Cc1ccccc1)S(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
CHEMBL2163688 163091 0 None None None Human 8.4 pIC50 = 8.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 648 11 1 8 4.7 CN(Cc1ccccc1)S(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1 10.1021/jm3009103
71451525 163100 0 None None None Human 8.4 pIC50 = 8.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 629 12 1 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOc1ncccn1 10.1021/jm3009103
CHEMBL2163697 163100 0 None None None Human 8.4 pIC50 = 8.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 629 12 1 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOc1ncccn1 10.1021/jm3009103
71451528 163118 0 None None None Human 8.4 pIC50 = 8.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 631 14 1 12 4.3 CCCCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
CHEMBL2163715 163118 0 None None None Human 8.4 pIC50 = 8.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 631 14 1 12 4.3 CCCCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
11059576 468323 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 7 1 6 5.2 CCCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL64726 468323 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 7 1 6 5.2 CCCOc1ccc2c(c1)C(c1ccc(OC)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
21041266 163439 0 None None None Human 8.4 pIC50 = 8.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 584 10 2 8 3.3 O=S(=O)(Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1)NC1CC1 10.1021/jm3009103
CHEMBL2165340 163439 0 None None None Human 8.4 pIC50 = 8.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 584 10 2 8 3.3 O=S(=O)(Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1)NC1CC1 10.1021/jm3009103
10625633 474056 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 514 12 1 8 2.4 COCCN(CCOC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9223 474056 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 514 12 1 8 2.4 COCCN(CCOC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10697636 332582 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 536 13 1 7 4.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1SCCS1 10.1021/jm980217s
CHEMBL430683 332582 0 None None None Rat 8.4 pIC50 = 8.4 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 536 13 1 7 4.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCC1SCCS1 10.1021/jm980217s
10279940 201481 0 None None None Human 8.4 pIC50 = 8.4 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 527 8 2 10 3.6 CC(=O)OCCc1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm9608366
CHEMBL296927 201481 0 None None None Human 8.4 pIC50 = 8.4 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 527 8 2 10 3.6 CC(=O)OCCc1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm9608366
44333578 18949 0 None None None Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 417 5 1 5 4.4 CCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
CHEMBL102773 18949 0 None None None Human 8.4 pIC50 = 8.4 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 417 5 1 5 4.4 CCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
44439111 197491 0 None None None Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 979 31 2 15 7.0 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOc2ccc(CC(=O)N(C)Cc3cc(-c4ncco4)ccc3-c3ccccc3S(=O)(=O)Nc3ccno3)cc2)cc1 10.1016/j.bmcl.2006.10.009
CHEMBL268201 197491 0 None None None Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 979 31 2 15 7.0 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOc2ccc(CC(=O)N(C)Cc3cc(-c4ncco4)ccc3-c3ccccc3S(=O)(=O)Nc3ccno3)cc2)cc1 10.1016/j.bmcl.2006.10.009
44295032 38691 0 None None None Rat 8.3 pIC50 = 8.3 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 520 10 1 9 4.7 COc1cccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)c1 10.1016/s0960-894x(98)00301-1
CHEMBL1206717 38691 0 None None None Rat 8.3 pIC50 = 8.3 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 520 10 1 9 4.7 COc1cccc(C(=O)/C(Cc2cc(OC)c(OC)c(OC)c2)=C(\C(=O)O)c2ccc3nsnc3c2)c1 10.1016/s0960-894x(98)00301-1
9959298 123282 0 None None None Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 552 10 2 7 5.4 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)N(C)C2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL175698 123282 0 None None None Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 552 10 2 7 5.4 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)N(C)C2CCCCC2)nc1C(=O)O 10.1021/jm9505932
10625530 473074 3 None None None Rat 8.3 pIC50 = 8.3 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm031041j
CHEMBL9162 473074 3 None None None Rat 8.3 pIC50 = 8.3 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm031041j
10625530 473074 3 None None None Rat 8.3 pIC50 = 8.3 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9162 473074 3 None None None Rat 8.3 pIC50 = 8.3 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10917653 468396 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 468 11 1 6 6.1 CCCCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL65292 468396 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 468 11 1 6 6.1 CCCCCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
104865 1454 67 None None None Human 8.3 pIC50 = 8.3 Binding
Binding affinity to human ETA receptorBinding affinity to human ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.ejmech.2016.06.006
3494 1454 67 None None None Human 8.3 pIC50 = 8.3 Binding
Binding affinity to human ETA receptorBinding affinity to human ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.ejmech.2016.06.006
392 1454 67 None None None Human 8.3 pIC50 = 8.3 Binding
Binding affinity to human ETA receptorBinding affinity to human ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.ejmech.2016.06.006
CHEMBL957 1454 67 None None None Human 8.3 pIC50 = 8.3 Binding
Binding affinity to human ETA receptorBinding affinity to human ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.ejmech.2016.06.006
DB00559 1454 67 None None None Human 8.3 pIC50 = 8.3 Binding
Binding affinity to human ETA receptorBinding affinity to human ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.ejmech.2016.06.006
104865 1454 67 None None None Rat 8.3 pIC50 = 8.3 Binding
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmc.2015.01.003
3494 1454 67 None None None Rat 8.3 pIC50 = 8.3 Binding
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmc.2015.01.003
392 1454 67 None None None Rat 8.3 pIC50 = 8.3 Binding
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmc.2015.01.003
CHEMBL957 1454 67 None None None Rat 8.3 pIC50 = 8.3 Binding
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmc.2015.01.003
DB00559 1454 67 None None None Rat 8.3 pIC50 = 8.3 Binding
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmc.2015.01.003
17885921 216461 0 None None None Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 453 6 1 6 5.2 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccn2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
CHEMBL314454 216461 0 None None None Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 453 6 1 6 5.2 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccn2)nn1CC1CCCCC1 10.1016/s0960-894x(00)00513-8
11798504 197441 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 468 9 1 6 3.5 CCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL267695 197441 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 468 9 1 6 3.5 CCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10648135 23647 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 472 13 1 5 4.7 C/C=C/CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
CHEMBL111218 23647 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 472 13 1 5 4.7 C/C=C/CC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
44314581 214582 0 None None None Pig 8.3 pIC50 = 8.3 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 591 11 6 5 2.8 Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)NC(Cc1c[nH]cn1)C(=O)O 10.1021/jm9600914
CHEMBL311134 214582 0 None None None Pig 8.3 pIC50 = 8.3 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 591 11 6 5 2.8 Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)NC(Cc1c[nH]cn1)C(=O)O 10.1021/jm9600914
11798504 197441 0 None None None Human 8.3 pIC50 = 8.3 Binding
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 468 9 1 6 3.5 CCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL267695 197441 0 None None None Human 8.3 pIC50 = 8.3 Binding
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 468 9 1 6 3.5 CCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
11113473 468388 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 472 6 1 5 6.3 CC(C)Oc1ccc2c(c1)C(c1ccc(C(C)C)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL65201 468388 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 472 6 1 5 6.3 CC(C)Oc1ccc2c(c1)C(c1ccc(C(C)C)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL2304006 485308 0 None None None Pig 8.3 pIC50 = 8.3 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 698 6 6 6 1.5 O=C(O)C[C@H]1NC(=O)[C@H](Cc2c(Br)[nH]c3ccccc23)NC(=O)[C@@H](C2CC2)NC(=O)[C@H](C2CCCC2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm9600914
44320419 216722 0 None None None Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 496 7 2 6 5.1 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1CCC(C(=O)O)CC1 10.1016/s0960-894x(00)00513-8
CHEMBL315805 216722 0 None None None Rat 8.3 pIC50 = 8.3 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 496 7 2 6 5.1 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1CCC(C(=O)O)CC1 10.1016/s0960-894x(00)00513-8
10576428 38493 0 None None None Human 8.3 pIC50 = 8.3 Binding
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 473 8 2 6 4.3 COc1ccc(C(=O)/C(Cc2ccc(NC(C)=O)cc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL1204673 38493 0 None None None Human 8.3 pIC50 = 8.3 Binding
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 473 8 2 6 4.3 COc1ccc(C(=O)/C(Cc2ccc(NC(C)=O)cc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL328942 486724 0 None None None Human 7.4 pIC50 = 7.4 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 923 25 9 8 4.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
18617318 215306 0 None None None Human 7.4 pIC50 = 7.4 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 394 3 1 4 3.3 Cc1noc(NS(=O)(=O)c2ccccc2Br)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL312266 215306 0 None None None Human 7.4 pIC50 = 7.4 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 394 3 1 4 3.3 Cc1noc(NS(=O)(=O)c2ccccc2Br)c1Br 10.1016/0960-894X(96)00441-6
10526002 22367 0 None None None Human 7.4 pIC50 = 7.4 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 417 5 1 7 3.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccnc2)cc1 10.1021/jm9606507
CHEMBL10910 22367 0 None None None Human 7.4 pIC50 = 7.4 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 417 5 1 7 3.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccnc2)cc1 10.1021/jm9606507
CHEMBL2304018 485320 0 None None None Pig 7.4 pIC50 = 7.4 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 630 6 6 6 1.1 CC(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Cl)[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC1=O 10.1021/jm9600914
18004820 40341 0 None None None Human 7.4 pIC50 = 7.4 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 527 9 2 7 4.7 CCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL12333 40341 0 None None None Human 7.4 pIC50 = 7.4 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 527 9 2 7 4.7 CCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
71456865 163131 0 None None None Human 7.4 pIC50 = 7.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 632 14 2 11 3.7 COc1nc(NS(=O)(=O)NCc2ccccc2)c(Oc2ccccc2OC)c(OCCOc2ncc(Br)cn2)n1 10.1021/jm3009103
CHEMBL2163727 163131 0 None None None Human 7.4 pIC50 = 7.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 632 14 2 11 3.7 COc1nc(NS(=O)(=O)NCc2ccccc2)c(Oc2ccccc2OC)c(OCCOc2ncc(Br)cn2)n1 10.1021/jm3009103
10504148 474164 0 None None None Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 459 10 1 5 6.7 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1ccccn1 10.1021/jm9707131
CHEMBL92965 474164 0 None None None Rat 7.4 pIC50 = 7.4 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 459 10 1 5 6.7 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1ccccn1 10.1021/jm9707131
104865 1454 67 None None None Human 7.4 pIC50 = 7.4 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(02)01084-3
3494 1454 67 None None None Human 7.4 pIC50 = 7.4 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(02)01084-3
392 1454 67 None None None Human 7.4 pIC50 = 7.4 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(02)01084-3
CHEMBL957 1454 67 None None None Human 7.4 pIC50 = 7.4 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(02)01084-3
DB00559 1454 67 None None None Human 7.4 pIC50 = 7.4 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(02)01084-3
CHEMBL2369709 485455 0 None None None Human 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cellsInhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cells
ChEMBL 830 21 8 8 1.4 CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00152-J
CHEMBL405100 487845 0 None None None Pig 7.4 pIC50 = 7.4 Binding
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL 967 24 9 9 4.0 CC[C@H](C)[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
CHEMBL438820 488745 0 None None None Pig 7.4 pIC50 = 7.4 Binding
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL 950 23 10 9 2.1 CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
10002033 201150 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 417 7 2 7 3.6 CCOC(=O)C(C)Nc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
CHEMBL29448 201150 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 417 7 2 7 3.6 CCOC(=O)C(C)Nc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
10718141 19561 0 None None None Human 6.4 pIC50 = 6.4 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 444 5 1 7 3.6 COC(=O)c1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL10622 19561 0 None None None Human 6.4 pIC50 = 6.4 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 444 5 1 7 3.6 COC(=O)c1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
10027018 198755 0 None None None Human 6.4 pIC50 = 6.4 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 454 4 1 5 5.1 O=C1OC(O)(c2ccc(Cl)c(Cl)c2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
CHEMBL275991 198755 0 None None None Human 6.4 pIC50 = 6.4 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 454 4 1 5 5.1 O=C1OC(O)(c2ccc(Cl)c(Cl)c2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
44279413 200132 0 None None None Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 400 2 2 3 3.3 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(Br)cc21 10.1016/0960-894X(95)00230-Q
CHEMBL286395 200132 0 None None None Human 6.4 pIC50 = 6.4 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 400 2 2 3 3.3 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(Br)cc21 10.1016/0960-894X(95)00230-Q
10716071 474218 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 401 7 1 5 5.4 O=[N+]([O-])c1ccc(OCc2ccsc2)cc1/C=C(/CO)c1ccccc1Cl 10.1021/jm970847e
CHEMBL93411 474218 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 401 7 1 5 5.4 O=[N+]([O-])c1ccc(OCc2ccsc2)cc1/C=C(/CO)c1ccccc1Cl 10.1021/jm970847e
44298330 201669 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 518 10 1 8 5.4 COC(=O)CCCc1onc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Sc1cccc(OC)c1 10.1016/s0960-894x(00)00366-8
CHEMBL298340 201669 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 518 10 1 8 5.4 COC(=O)CCCc1onc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Sc1cccc(OC)c1 10.1016/s0960-894x(00)00366-8
CHEMBL85341 489392 0 None None None Human 6.4 pIC50 = 6.4 Binding
Inhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cellsInhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cells
ChEMBL 863 24 10 9 2.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00095a029
10792782 259251 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 4 6 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL368847 259251 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 4 6 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL147510 484694 0 None None None Human 6.4 pIC50 = 6.4 Binding
The inhibitory constant was evaluated against Endothelin A receptorThe inhibitory constant was evaluated against Endothelin A receptor
ChEMBL 864 25 11 10 1.0 CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
10087191 201944 0 None None None Human 5.4 pIC50 = 5.4 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3c(N)cccc23)c1C 10.1021/jm00029a001
CHEMBL30039 201944 0 None None None Human 5.4 pIC50 = 5.4 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3c(N)cccc23)c1C 10.1021/jm00029a001
10087191 201944 0 None None None Rat 5.4 pIC50 = 5.4 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3c(N)cccc23)c1C 10.1021/jm00008a013
CHEMBL30039 201944 0 None None None Rat 5.4 pIC50 = 5.4 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2cccc3c(N)cccc23)c1C 10.1021/jm00008a013
2514 334052 77 None None None Rat 5.4 pIC50 = 5.4 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 10.1021/jm00008a013
5329 334052 77 None None None Rat 5.4 pIC50 = 5.4 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 10.1021/jm00008a013
CHEMBL443 334052 77 None None None Rat 5.4 pIC50 = 5.4 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 10.1021/jm00008a013
DB01015 334052 77 None None None Rat 5.4 pIC50 = 5.4 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 10.1021/jm00008a013
CHEMBL405709 487878 0 None None None Human 5.4 pIC50 = 5.4 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 957 25 9 8 4.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
2514 334052 77 None None None Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 10.1021/jm00004a012
5329 334052 77 None None None Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 10.1021/jm00004a012
CHEMBL443 334052 77 None None None Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 10.1021/jm00004a012
DB01015 334052 77 None None None Rat 5.4 pIC50 = 5.4 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 10.1021/jm00004a012
44327619 474330 0 None None None Rat 5.4 pIC50 = 5.4 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 511 6 1 8 3.5 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)n2nc(C(C)(C)C)ccc2=O)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL94102 474330 0 None None None Rat 5.4 pIC50 = 5.4 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 511 6 1 8 3.5 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)n2nc(C(C)(C)C)ccc2=O)cc1 10.1016/S0960-894X(96)00617-8
44327714 474801 0 None None None Rat 5.4 pIC50 = 5.4 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 575 8 1 9 4.2 COc1ccc(-c2cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)n2)cc1 10.1016/S0960-894X(96)00617-8
CHEMBL96935 474801 0 None None None Rat 5.4 pIC50 = 5.4 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 575 8 1 9 4.2 COc1ccc(-c2cc(C)c(=O)n(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)n2)cc1 10.1016/S0960-894X(96)00617-8
182140 372255 25 None None None Human 4.4 pIC50 = 4.4 Binding
Displacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cellsDisplacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells
ChEMBL 430 8 0 7 3.7 COC[C@@H]1Cc2cc(OC)c3c(c2[C@H](c2ccc(OC)c(OC)c2)[C@H]1COC)OCO3 10.1021/np50124a006
CHEMBL510130 372255 25 None None None Human 4.4 pIC50 = 4.4 Binding
Displacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cellsDisplacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells
ChEMBL 430 8 0 7 3.7 COC[C@@H]1Cc2cc(OC)c3c(c2[C@H](c2ccc(OC)c(OC)c2)[C@H]1COC)OCO3 10.1021/np50124a006
44277130 199656 0 None None None Rat 4.4 pIC50 = 4.4 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 450 8 1 7 3.6 COc1cccc(Cn2nc(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2OCCO)c1 10.1016/s0960-894x(00)00232-8
CHEMBL283037 199656 0 None None None Rat 4.4 pIC50 = 4.4 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 450 8 1 7 3.6 COc1cccc(Cn2nc(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2OCCO)c1 10.1016/s0960-894x(00)00232-8
44277131 216494 0 None None None Rat 4.4 pIC50 = 4.4 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 380 5 1 3 4.0 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc(F)cc3)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144603 216494 0 None None None Rat 4.4 pIC50 = 4.4 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 380 5 1 3 4.0 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc(F)cc3)c2=O)c1 10.1016/s0960-894x(00)00232-8
44357135 235170 0 None None None Pig 4.4 pIC50 = 4.4 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 642 10 6 8 -0.1 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)c2ccccc2NC=O)NC1=O 10.1021/jm00021a021
CHEMBL335863 235170 0 None None None Pig 4.4 pIC50 = 4.4 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 642 10 6 8 -0.1 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)c2ccccc2NC=O)NC1=O 10.1021/jm00021a021
10814222 23856 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 470 10 1 6 3.4 CCCN(C)C(=O)CN1C[C@H](c2ccc(OC)cc2OC)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL112325 23856 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 470 10 1 6 3.4 CCCN(C)C(=O)CN1C[C@H](c2ccc(OC)cc2OC)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
18995992 200025 0 None None None Human 7.4 pIC50 = 7.4 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 507 7 1 9 5.0 COc1ccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC 10.1016/0960-894X(96)00232-6
CHEMBL28563 200025 0 None None None Human 7.4 pIC50 = 7.4 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 507 7 1 9 5.0 COc1ccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc1OC 10.1016/0960-894X(96)00232-6
44339755 24082 0 None None None Rat 7.4 pIC50 = 7.4 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 551 12 1 7 2.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CN1CCCCS1(=O)=O 10.1021/jm980217s
CHEMBL113589 24082 0 None None None Rat 7.4 pIC50 = 7.4 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 551 12 1 7 2.7 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CN1CCCCS1(=O)=O 10.1021/jm980217s
10763680 239411 0 None None None Rat 7.4 pIC50 = 7.4 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 403 7 1 6 4.1 N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1OC(C(=O)O)c1ccccc1 10.1021/jm990378b
CHEMBL355413 239411 0 None None None Rat 7.4 pIC50 = 7.4 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 403 7 1 6 4.1 N#Cc1ccc(OCc2ccc3c(c2)OCO3)cc1OC(C(=O)O)c1ccccc1 10.1021/jm990378b
9894460 473657 11 None None None Rat 7.4 pIC50 = 7.4 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/S0960-894X(96)00617-8
CHEMBL8978 473657 11 None None None Rat 7.4 pIC50 = 7.4 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/S0960-894X(96)00617-8
10554410 239038 0 None None None Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 538 10 3 7 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)OC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL353320 239038 0 None None None Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 538 10 3 7 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)OC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
10916597 468343 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 410 7 1 5 5.4 CCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm031041j
CHEMBL64832 468343 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 410 7 1 5 5.4 CCCCC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm031041j
CHEMBL304756 486451 0 None None None Pig 6.4 pIC50 = 6.4 Binding
Binding activity against Endothelin A receptor of Porcine aortic smooth muscle membranesBinding activity against Endothelin A receptor of Porcine aortic smooth muscle membranes
ChEMBL 624 8 6 6 1.2 CC(C)C[C@@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00089a028
11058658 468281 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 409 7 1 5 4.8 CCCCC1=C(C(N)=O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL64558 468281 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 409 7 1 5 4.8 CCCCC1=C(C(N)=O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL337897 486993 0 None None None Pig 6.4 pIC50 = 6.4 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 624 8 6 6 1.2 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
4642915 198236 0 None None None Rat 5.4 pIC50 = 5.4 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 402 5 3 5 4.1 Cc1noc(NS(=O)(=O)c2ccc(N/C(S)=N/c3ccccc3)cc2)c1C 10.1021/jm00008a013
CHEMBL27256 198236 0 None None None Rat 5.4 pIC50 = 5.4 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 402 5 3 5 4.1 Cc1noc(NS(=O)(=O)c2ccc(N/C(S)=N/c3ccccc3)cc2)c1C 10.1021/jm00008a013
44213925 221197 0 None None None Rat 5.4 pIC50 = 5.4 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 593 9 1 9 4.1 COc1ccc(C2=NN(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)C(=O)CC2)cc1OC 10.1016/S0960-894X(96)00617-8
CHEMBL328683 221197 0 None None None Rat 5.4 pIC50 = 5.4 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 593 9 1 9 4.1 COc1ccc(C2=NN(C(C(=O)NS(=O)(=O)c3ccc(C(C)C)cc3)c3ccc4c(c3)OCO4)C(=O)CC2)cc1OC 10.1016/S0960-894X(96)00617-8
44266532 18849 0 None None None Human 5.4 pIC50 = 5.4 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 401 3 1 6 4.5 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n1-c1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL10211 18849 0 None None None Human 5.4 pIC50 = 5.4 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 401 3 1 6 4.5 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2ccccc2n1-c1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
10816264 122706 0 None None None Rat 4.4 pIC50 = 4.4 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 539 9 4 5 5.0 Cc1sc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
CHEMBL173181 122706 0 None None None Rat 4.4 pIC50 = 4.4 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 539 9 4 5 5.0 Cc1sc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
10840476 259723 0 None None None Rat 4.4 pIC50 = 4.4 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 553 10 4 5 5.3 CCc1sc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
CHEMBL369420 259723 0 None None None Rat 4.4 pIC50 = 4.4 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 553 10 4 5 5.3 CCc1sc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
23445345 468109 0 None None None Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 378 5 1 7 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccccc2)c1C 10.1016/S0960-894X(97)00367-3
CHEMBL63611 468109 0 None None None Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 378 5 1 7 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccccc2)c1C 10.1016/S0960-894X(97)00367-3
10280531 327952 0 None None None Human 6.4 pIC50 = 6.4 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 541 10 2 7 5.1 CCCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL417429 327952 0 None None None Human 6.4 pIC50 = 6.4 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 541 10 2 7 5.1 CCCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
10366742 216752 0 None None None Human 7.4 pIC50 = 7.4 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 454 6 1 5 5.5 CCCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(96)00496-9
CHEMBL316012 216752 0 None None None Human 7.4 pIC50 = 7.4 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 454 6 1 5 5.5 CCCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(96)00496-9
44371410 102662 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 439 5 1 5 5.5 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3C)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL156453 102662 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 439 5 1 5 5.5 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3C)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL406279 487904 0 None None None Human 6.4 pIC50 = 6.4 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 805 22 9 8 1.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
44383187 122937 0 None None None Human 6.4 pIC50 = 6.4 Binding
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 617 13 4 5 4.5 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NCc1cccc(CCC(=O)O)c1 10.1016/0960-894X(95)00144-I
CHEMBL173974 122937 0 None None None Human 6.4 pIC50 = 6.4 Binding
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 617 13 4 5 4.5 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NCc1cccc(CCC(=O)O)c1 10.1016/0960-894X(95)00144-I
15296635 199754 0 None None None Pig 6.4 pIC50 = 6.4 Binding
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 488 11 5 5 2.7 CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL283591 199754 0 None None None Pig 6.4 pIC50 = 6.4 Binding
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 488 11 5 5 2.7 CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
44279516 200038 0 None None None Pig 6.4 pIC50 = 6.4 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 512 13 5 5 2.6 CC(C)C[C@H](NC(=O)Cc1cccs1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL285729 200038 0 None None None Pig 6.4 pIC50 = 6.4 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 512 13 5 5 2.6 CC(C)C[C@H](NC(=O)Cc1cccs1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
15340613 216503 0 None None None Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 414 6 1 5 4.2 COc1cccc(Cn2[nH]c(-c3ccccc3)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144732 216503 0 None None None Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 414 6 1 5 4.2 COc1cccc(Cn2[nH]c(-c3ccccc3)c(Cc3ccc4c(c3)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
44317215 470119 0 None None None Human 5.4 pIC50 = 5.4 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 266 3 1 4 2.4 Cc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/0960-894X(96)00441-6
CHEMBL78952 470119 0 None None None Human 5.4 pIC50 = 5.4 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 266 3 1 4 2.4 Cc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/0960-894X(96)00441-6
10816963 232378 0 None None None Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 574 12 2 7 5.0 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC)cc1 10.1021/jm990170q
CHEMBL331625 232378 0 None None None Human 5.4 pIC50 = 5.4 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 574 12 2 7 5.0 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC)cc1 10.1021/jm990170q
CHEMBL1791015 484824 0 None None None Pig 5.4 pIC50 = 5.4 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 586 7 8 7 -0.9 CC(C)C[C@H]1NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44368417 97935 0 None None None Pig 4.4 pIC50 = 4.4 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 504 12 2 6 4.9 COc1ccc(CN(Cc2cc(OC)c(OC)c(OC)c2)C(Cc2c[nH]c3ccccc23)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
CHEMBL152065 97935 0 None None None Pig 4.4 pIC50 = 4.4 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 504 12 2 6 4.9 COc1ccc(CN(Cc2cc(OC)c(OC)c(OC)c2)C(Cc2c[nH]c3ccccc23)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
10383833 200283 0 None None None Rat 4.4 pIC50 = 4.4 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2ccc(S(=O)(=O)Nc3onc(C)c3C)cc2c1 10.1021/jm00008a013
CHEMBL28751 200283 0 None None None Rat 4.4 pIC50 = 4.4 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2ccc(S(=O)(=O)Nc3onc(C)c3C)cc2c1 10.1021/jm00008a013
10383833 200283 0 None None None Rat 4.4 pIC50 = 4.4 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2ccc(S(=O)(=O)Nc3onc(C)c3C)cc2c1 10.1021/jm00004a012
CHEMBL28751 200283 0 None None None Rat 4.4 pIC50 = 4.4 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2ccc(S(=O)(=O)Nc3onc(C)c3C)cc2c1 10.1021/jm00004a012
CHEMBL265066 197141 0 None None None Pig 6.4 pIC50 = 6.4 Binding
Tested for its inhibitory activity against Endothelin A receptorTested for its inhibitory activity against Endothelin A receptor
ChEMBL 646 8 2 13 5.8 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC(=O)C2=C(C)N=C(C)/C(=C(/O)OC)[C@@H]2c2cccc([N+](=O)[O-])c2)[C@H]1c1cccc([N+](=O)[O-])c1 10.1016/S0960-894X(01)81025-8
1009 399 28 None None None Human 5.4 pIC50 = 5.4 Binding
Inhibition of 125I labeled ET-1 binding to EDNRAInhibition of 125I labeled ET-1 binding to EDNRA
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.6019/CHEMBL4507261
5310991 399 28 None None None Human 5.4 pIC50 = 5.4 Binding
Inhibition of 125I labeled ET-1 binding to EDNRAInhibition of 125I labeled ET-1 binding to EDNRA
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.6019/CHEMBL4507261
CHEMBL332794 399 28 None None None Human 5.4 pIC50 = 5.4 Binding
Inhibition of 125I labeled ET-1 binding to EDNRAInhibition of 125I labeled ET-1 binding to EDNRA
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.6019/CHEMBL4507261
9913198 19656 0 None None None Human 7.4 pIC50 = 7.4 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 484 5 1 6 4.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(C(F)(F)F)c2)cc1 10.1021/jm9606507
CHEMBL10676 19656 0 None None None Human 7.4 pIC50 = 7.4 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 484 5 1 6 4.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(C(F)(F)F)c2)cc1 10.1021/jm9606507
11733450 468435 0 None None None Rat 7.4 pIC50 = 7.4 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 6 1 7 5.0 CCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL65658 468435 0 None None None Rat 7.4 pIC50 = 7.4 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 6 1 7 5.0 CCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
10502577 26673 0 None None None Human 7.4 pIC50 = 7.4 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 426 7 1 7 3.9 COc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 10.1021/jm9700068
CHEMBL1185771 26673 0 None None None Human 7.4 pIC50 = 7.4 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 426 7 1 7 3.9 COc1ccc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)cc1 10.1021/jm9700068
10599829 197447 0 None None None Rat 7.4 pIC50 = 7.4 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 454 9 2 6 3.2 CCCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL267761 197447 0 None None None Rat 7.4 pIC50 = 7.4 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 454 9 2 6 3.2 CCCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
44266575 18987 0 None None None Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 459 6 1 7 5.2 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2-c1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL10302 18987 0 None None None Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 459 6 1 7 5.2 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2-c1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
44317005 469893 0 None None None Human 6.4 pIC50 = 6.4 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 320 3 1 4 3.4 Cc1noc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL76949 469893 0 None None None Human 6.4 pIC50 = 6.4 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 320 3 1 4 3.4 Cc1noc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)c1C 10.1016/0960-894X(96)00441-6
10070783 197378 0 None None None Human 6.4 pIC50 = 6.4 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 420 4 1 5 4.5 O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
CHEMBL267094 197378 0 None None None Human 6.4 pIC50 = 6.4 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 420 4 1 5 4.5 O=C1OC(O)(c2ccc(Cl)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
44298305 387067 0 None None None Rat 5.4 pIC50 = 5.4 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 504 10 2 7 5.3 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC(=O)O)c1 10.1016/s0960-894x(00)00366-8
CHEMBL53097 387067 0 None None None Rat 5.4 pIC50 = 5.4 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 504 10 2 7 5.3 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC(=O)O)c1 10.1016/s0960-894x(00)00366-8
44276948 216495 0 None None None Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 396 5 1 3 4.5 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc(Cl)cc3)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144604 216495 0 None None None Rat 5.4 pIC50 = 5.4 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 396 5 1 3 4.5 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccc(Cl)cc3)c2=O)c1 10.1016/s0960-894x(00)00232-8
9820754 218168 0 None None None Human 5.4 pIC50 = 5.4 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 371 3 0 5 4.4 COC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL320236 218168 0 None None None Human 5.4 pIC50 = 5.4 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 371 3 0 5 4.4 COC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
10604167 26685 0 None None None Human 6.4 pIC50 = 6.4 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 640 10 2 6 6.4 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)(c2ccccc2)c2ccccc2)cc1 10.1021/jm990171i
CHEMBL1185826 26685 0 None None None Human 6.4 pIC50 = 6.4 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 640 10 2 6 6.4 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)(c2ccccc2)c2ccccc2)cc1 10.1021/jm990171i
10647172 473712 0 None None None Rat 5.4 pIC50 = 5.4 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 449 6 1 5 4.6 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2Cc2ccc(F)cc2)cc1 10.1021/jm9505369
CHEMBL9012 473712 0 None None None Rat 5.4 pIC50 = 5.4 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 449 6 1 5 4.6 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2Cc2ccc(F)cc2)cc1 10.1021/jm9505369
44265906 197581 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 441 9 1 6 3.9 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CCOCC(C)C)cc1 10.1021/jm9505369
CHEMBL268902 197581 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 441 9 1 6 3.9 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CCOCC(C)C)cc1 10.1021/jm9505369
18617377 470315 0 None None None Human 7.4 pIC50 = 7.4 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 344 3 1 4 3.2 Cc1ccc(C)c(S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/0960-894X(96)00441-6
CHEMBL80484 470315 0 None None None Human 7.4 pIC50 = 7.4 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 344 3 1 4 3.2 Cc1ccc(C)c(S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/0960-894X(96)00441-6
10668427 330229 0 None None None Rat 7.4 pIC50 = 7.4 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 395 7 1 6 3.8 N#Cc1ccc(OCc2ccnnc2)cc1OC(C(=O)O)c1ccccc1Cl 10.1021/jm990378b
CHEMBL423608 330229 0 None None None Rat 7.4 pIC50 = 7.4 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 395 7 1 6 3.8 N#Cc1ccc(OCc2ccnnc2)cc1OC(C(=O)O)c1ccccc1Cl 10.1021/jm990378b
10765750 328162 0 None None None Rat 7.4 pIC50 = 7.4 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 445 8 1 6 3.0 CC[S+]([O-])CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL417972 328162 0 None None None Rat 7.4 pIC50 = 7.4 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 445 8 1 6 3.0 CC[S+]([O-])CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
44383753 122842 0 None None None Human 7.4 pIC50 = 7.4 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 466 5 1 5 5.7 Cc1cc(C)c(/C=C/c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL173761 122842 0 None None None Human 7.4 pIC50 = 7.4 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 466 5 1 5 5.7 Cc1cc(C)c(/C=C/c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
44439105 333365 0 None None None Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 848 26 2 12 6.5 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOc2ccc(-c3ccccc3S(=O)(=O)Nc3ccno3)c(CN(C)C(=O)CC(C)(C)C)c2)cc1 10.1016/j.bmcl.2006.10.009
CHEMBL436821 333365 0 None None None Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 848 26 2 12 6.5 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOc2ccc(-c3ccccc3S(=O)(=O)Nc3ccno3)c(CN(C)C(=O)CC(C)(C)C)c2)cc1 10.1016/j.bmcl.2006.10.009
10357554 197867 0 None None None Human 6.4 pIC50 = 6.4 Binding
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 302 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C 10.1016/0960-894X(96)00441-6
CHEMBL27065 197867 0 None None None Human 6.4 pIC50 = 6.4 Binding
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 302 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2cccc3ccccc23)c1C 10.1016/0960-894X(96)00441-6
10972369 332801 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 448 6 3 6 4.9 COc1ccc(C2=C(C(=O)O)C(c3ccc(O)c(O)c3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL432489 332801 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 448 6 3 6 4.9 COc1ccc(C2=C(C(=O)O)C(c3ccc(O)c(O)c3)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
11801544 124529 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 589 10 4 6 5.1 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2C3CC4CC(C3)CC2C4)nc1C(=O)O 10.1021/jm950592+
CHEMBL177261 124529 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 589 10 4 6 5.1 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2C3CC4CC(C3)CC2C4)nc1C(=O)O 10.1021/jm950592+
CHEMBL135907 484658 0 None None None Pig 6.4 pIC50 = 6.4 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 598 8 7 6 0.7 CC(C)C[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC1=O 10.1021/jm00021a021
23445562 200766 0 None None None Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 398 5 1 7 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccccc2)c1Cl 10.1016/S0960-894X(97)00367-3
CHEMBL291891 200766 0 None None None Human 5.4 pIC50 = 5.4 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 398 5 1 7 3.7 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccccc2)c1Cl 10.1016/S0960-894X(97)00367-3
CHEMBL438194 488699 13 None None None Human 5.4 pIC50 = 5.4 Binding
Inhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cellsInhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cells
ChEMBL 923 25 9 8 4.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00095a029
CHEMBL34540 487100 16 None None None Rat 4.4 pIC50 = 4.4 Binding
Compound was evaluated for the binding affinity to endothelin receptor in the rat heart ventricle.Compound was evaluated for the binding affinity to endothelin receptor in the rat heart ventricle.
ChEMBL 795 23 10 9 1.1 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00087a001
104865 1454 67 None None None Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at ET-A receptor (unknown origin)Antagonist activity at ET-A receptor (unknown origin)
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.5b01781
3494 1454 67 None None None Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at ET-A receptor (unknown origin)Antagonist activity at ET-A receptor (unknown origin)
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.5b01781
392 1454 67 None None None Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at ET-A receptor (unknown origin)Antagonist activity at ET-A receptor (unknown origin)
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.5b01781
CHEMBL957 1454 67 None None None Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at ET-A receptor (unknown origin)Antagonist activity at ET-A receptor (unknown origin)
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.5b01781
DB00559 1454 67 None None None Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at ET-A receptor (unknown origin)Antagonist activity at ET-A receptor (unknown origin)
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.5b01781
10839947 236150 0 None None None Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 530 9 2 6 5.0 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
CHEMBL339657 236150 0 None None None Human 7.4 pIC50 = 7.4 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 530 9 2 6 5.0 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
104865 1454 67 None None None Human 7.4 pIC50 = 7.4 Binding
Displacement of 125I-ET1 from human smooth muscle ETA receptorDisplacement of 125I-ET1 from human smooth muscle ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
3494 1454 67 None None None Human 7.4 pIC50 = 7.4 Binding
Displacement of 125I-ET1 from human smooth muscle ETA receptorDisplacement of 125I-ET1 from human smooth muscle ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
392 1454 67 None None None Human 7.4 pIC50 = 7.4 Binding
Displacement of 125I-ET1 from human smooth muscle ETA receptorDisplacement of 125I-ET1 from human smooth muscle ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
CHEMBL957 1454 67 None None None Human 7.4 pIC50 = 7.4 Binding
Displacement of 125I-ET1 from human smooth muscle ETA receptorDisplacement of 125I-ET1 from human smooth muscle ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
DB00559 1454 67 None None None Human 7.4 pIC50 = 7.4 Binding
Displacement of 125I-ET1 from human smooth muscle ETA receptorDisplacement of 125I-ET1 from human smooth muscle ETA receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
104865 1454 67 None None None Human 7.4 pIC50 = 7.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm3009103
3494 1454 67 None None None Human 7.4 pIC50 = 7.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm3009103
392 1454 67 None None None Human 7.4 pIC50 = 7.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm3009103
CHEMBL957 1454 67 None None None Human 7.4 pIC50 = 7.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm3009103
DB00559 1454 67 None None None Human 7.4 pIC50 = 7.4 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm3009103
10741025 355527 0 None None None Human 7.4 pIC50 = 7.4 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 424 6 1 6 4.5 Cc1cc(C)cc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c1 10.1021/jm9700068
CHEMBL47765 355527 0 None None None Human 7.4 pIC50 = 7.4 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 424 6 1 6 4.5 Cc1cc(C)cc(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c1 10.1021/jm9700068
CHEMBL347948 487105 0 None None None Mouse 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL 831 21 8 8 2.0 CC[C@H](C)[C@@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81219-1
18184234 124953 0 None None None Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 605 15 2 10 4.2 CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL177802 124953 0 None None None Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 605 15 2 10 4.2 CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
10599230 473927 0 None None None Rat 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 440 8 2 6 2.8 CCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm031041j
CHEMBL9141 473927 0 None None None Rat 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 440 8 2 6 2.8 CCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm031041j
10599230 473927 0 None None None Human 7.3 pIC50 = 7.3 Binding
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 440 8 2 6 2.8 CCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9141 473927 0 None None None Human 7.3 pIC50 = 7.3 Binding
Radioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cellsRadioligand binding selectivity to human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 440 8 2 6 2.8 CCCNC(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
11767189 24260 0 None None None Pig 7.3 pIC50 = 7.3 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 601 11 1 10 5.8 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2cnc3ccccc3n2)c1 10.1021/jm0102304
CHEMBL114704 24260 0 None None None Pig 7.3 pIC50 = 7.3 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 601 11 1 10 5.8 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2cnc3ccccc3n2)c1 10.1021/jm0102304
10793053 25735 0 None None None Human 7.3 pIC50 = 7.3 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 564 9 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2ccccc2)cc1 10.1021/jm990171i
CHEMBL1180363 25735 0 None None None Human 7.3 pIC50 = 7.3 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 564 9 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2ccccc2)cc1 10.1021/jm990171i
15340617 199455 0 None None None Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 464 8 1 7 3.7 COc1cccc(Cn2nc(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2OCC(=O)O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL281677 199455 0 None None None Rat 6.4 pIC50 = 6.4 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 464 8 1 7 3.7 COc1cccc(Cn2nc(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2OCC(=O)O)c1 10.1016/s0960-894x(00)00232-8
44386621 124037 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 549 10 4 6 4.5 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O 10.1021/jm950592+
CHEMBL176653 124037 0 None None None Rat 6.4 pIC50 = 6.4 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 549 10 4 6 4.5 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O 10.1021/jm950592+
10650331 260436 0 None None None Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 551 10 3 6 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)N(C)C(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL369821 260436 0 None None None Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 551 10 3 6 5.0 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)N(C)C(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
56678451 126035 0 None None None Human 5.4 pIC50 = 5.4 Binding
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 25 8 8 4.5 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(c1ccccc1)c1ccccc1)N(C)C(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm970161m
CHEMBL1793927 126035 0 None None None Human 5.4 pIC50 = 5.4 Binding
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 25 8 8 4.5 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(c1ccccc1)c1ccccc1)N(C)C(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm970161m
10205429 124364 0 None None None Human 6.3 pIC50 = 6.3 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 470 8 2 9 2.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(C)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL177111 124364 0 None None None Human 6.3 pIC50 = 6.3 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 470 8 2 9 2.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(C)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
71458717 163099 0 None None None Human 5.3 pIC50 = 5.3 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 433 9 2 10 1.5 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCCO 10.1021/jm3009103
CHEMBL2163696 163099 0 None None None Human 5.3 pIC50 = 5.3 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 433 9 2 10 1.5 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCCO 10.1021/jm3009103
10598840 123261 0 None None None Rat 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 432 9 1 5 4.7 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2cc(OC)cc(OC)c2)cc1 10.1021/jm031041j
CHEMBL175545 123261 0 None None None Rat 7.3 pIC50 = 7.3 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 432 9 1 5 4.7 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2cc(OC)cc(OC)c2)cc1 10.1021/jm031041j
10670372 197560 0 None None None Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 7 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3cc(OC)cc(OC)c3)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL268754 197560 0 None None None Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 7 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3cc(OC)cc(OC)c3)=C2Cc2ccccc2)cc1 10.1021/jm9606507
44314664 469584 0 None None None Pig 7.3 pIC50 = 7.3 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 615 12 5 4 5.1 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CCCC1)C(=O)O 10.1021/jm9600914
CHEMBL74000 469584 0 None None None Pig 7.3 pIC50 = 7.3 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 615 12 5 4 5.1 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CCCC1)C(=O)O 10.1021/jm9600914
76330201 176295 0 None None None Human 7.3 pIC50 = 7.3 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 526 6 1 7 4.5 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(Cl)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261363 176295 0 None None None Human 7.3 pIC50 = 7.3 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 526 6 1 7 4.5 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(Cl)ccc12 10.1007/s00044-004-0021-y
10479787 122391 0 None None None Human 7.3 pIC50 = 7.3 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 468 6 1 5 5.3 Cc1cc(C)c(CCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL171972 122391 0 None None None Human 7.3 pIC50 = 7.3 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 468 6 1 5 5.3 Cc1cc(C)c(CCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
18995988 200502 0 None None None Human 5.3 pIC50 = 5.3 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 389 6 1 4 5.5 COc1cccc(Sc2c(C(=O)O)n(Cc3ccccc3)c3ccccc23)c1 10.1016/0960-894X(96)00232-6
CHEMBL28948 200502 0 None None None Human 5.3 pIC50 = 5.3 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 389 6 1 4 5.5 COc1cccc(Sc2c(C(=O)O)n(Cc3ccccc3)c3ccccc23)c1 10.1016/0960-894X(96)00232-6
10029811 198255 0 None None None Rat 4.3 pIC50 = 4.3 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 525 8 2 5 6.4 Cc1noc(NS(=O)(=O)c2cccc3c(NC(=O)CC(c4ccccc4)c4ccccc4)cccc23)c1C 10.1021/jm00008a013
CHEMBL27262 198255 0 None None None Rat 4.3 pIC50 = 4.3 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 525 8 2 5 6.4 Cc1noc(NS(=O)(=O)c2cccc3c(NC(=O)CC(c4ccccc4)c4ccccc4)cccc23)c1C 10.1021/jm00008a013
44279127 199688 0 None None None Human 7.3 pIC50 = 7.3 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 432 3 2 3 4.8 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccc(Cl)cc3)cc21 10.1016/0960-894X(95)00230-Q
CHEMBL283200 199688 0 None None None Human 7.3 pIC50 = 7.3 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 432 3 2 3 4.8 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccc(Cl)cc3)cc21 10.1016/0960-894X(95)00230-Q
10815168 332875 0 None None None Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 497 5 2 6 5.2 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(C(C)(C)C)cc2)c1Br 10.1021/jm9608366
CHEMBL433074 332875 0 None None None Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 497 5 2 6 5.2 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(C(C)(C)C)cc2)c1Br 10.1021/jm9608366
9869444 197559 0 None None None Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2c1 10.1016/0960-894X(96)00170-9
CHEMBL268751 197559 0 None None None Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2c1 10.1016/0960-894X(96)00170-9
CHEMBL342440 487066 0 None None None Pig 7.3 pIC50 = 7.3 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 610 8 6 6 1.0 CCC[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC1=O 10.1021/jm00021a021
23445250 332835 0 None None None Human 7.3 pIC50 = 7.3 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 468 6 1 5 5.8 Cc1cc(CC(C)C)ccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL432815 332835 0 None None None Human 7.3 pIC50 = 7.3 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 468 6 1 5 5.8 Cc1cc(CC(C)C)ccc1-c1ccsc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(96)00496-9
44316515 469871 1 None None None Human 6.3 pIC50 = 6.3 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 360 4 1 5 2.9 COc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C 10.1016/0960-894X(96)00441-6
CHEMBL76779 469871 1 None None None Human 6.3 pIC50 = 6.3 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 360 4 1 5 2.9 COc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C 10.1016/0960-894X(96)00441-6
44283420 213520 0 None None None Pig 6.3 pIC50 = 6.3 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 594 13 5 5 4.2 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
44314472 213520 0 None None None Pig 6.3 pIC50 = 6.3 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 594 13 5 5 4.2 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL309003 213520 0 None None None Pig 6.3 pIC50 = 6.3 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 594 13 5 5 4.2 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL414175 213520 0 None None None Pig 6.3 pIC50 = 6.3 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 594 13 5 5 4.2 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
10626177 123158 0 None None None Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 535 11 4 5 4.8 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)CC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL174871 123158 0 None None None Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 535 11 4 5 4.8 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)CC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
44283420 213520 0 None None None Pig 6.3 pIC50 = 6.3 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 594 13 5 5 4.2 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
44314472 213520 0 None None None Pig 6.3 pIC50 = 6.3 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 594 13 5 5 4.2 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
CHEMBL309003 213520 0 None None None Pig 6.3 pIC50 = 6.3 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 594 13 5 5 4.2 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
CHEMBL414175 213520 0 None None None Pig 6.3 pIC50 = 6.3 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 594 13 5 5 4.2 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
23548251 163110 0 None None None Human 5.3 pIC50 = 5.3 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 661 16 1 14 4.0 COc1cc(OC)nc(OCCOc2nc(-c3ncccn3)nc(NS(=O)(=O)CCc3ccccc3)c2Oc2ccccc2OC)n1 10.1021/jm3009103
CHEMBL2163707 163110 0 None None None Human 5.3 pIC50 = 5.3 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 661 16 1 14 4.0 COc1cc(OC)nc(OCCOc2nc(-c3ncccn3)nc(NS(=O)(=O)CCc3ccccc3)c2Oc2ccccc2OC)n1 10.1021/jm3009103
11801523 22572 0 None None None Rat 7.3 pIC50 = 7.3 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 588 16 1 7 5.3 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCC)cc1 10.1021/jm970101g
CHEMBL109242 22572 0 None None None Rat 7.3 pIC50 = 7.3 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 588 16 1 7 5.3 CCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCC)cc1 10.1021/jm970101g
10961960 467946 0 None None None Rat 7.3 pIC50 = 7.3 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 487 8 1 7 4.4 CCCCC1=C(C(=O)NS(C)(=O)=O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL62633 467946 0 None None None Rat 7.3 pIC50 = 7.3 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 487 8 1 7 4.4 CCCCC1=C(C(=O)NS(C)(=O)=O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL304260 486449 0 None None None Pig 7.3 pIC50 = 7.3 Binding
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL 907 22 9 8 3.2 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
9830495 259040 0 None None None Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 618 14 2 9 5.0 CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL368617 259040 0 None None None Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 618 14 2 9 5.0 CCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
137661460 315220 0 None None None Human 7.3 pIC50 = 7.3 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 565 10 2 9 4.4 C=CCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4100579 315220 0 None None None Human 7.3 pIC50 = 7.3 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 565 10 2 9 4.4 C=CCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL2370255 485552 0 None None None Human 6.3 pIC50 = 6.3 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 937 27 9 8 4.8 CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10645550 197660 0 None None None Human 6.3 pIC50 = 6.3 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 416 5 1 6 3.8 COc1ccccc1C1(O)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1ccccc1 10.1021/jm9606507
CHEMBL269461 197660 0 None None None Human 6.3 pIC50 = 6.3 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 416 5 1 6 3.8 COc1ccccc1C1(O)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1ccccc1 10.1021/jm9606507
11145841 201095 0 None None None Rat 5.3 pIC50 = 5.3 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 528 9 1 6 6.9 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC3CCCC3)cc1)O2 10.1021/jm010382z
CHEMBL294127 201095 0 None None None Rat 5.3 pIC50 = 5.3 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 528 9 1 6 6.9 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC3CCCC3)cc1)O2 10.1021/jm010382z
44279129 216649 0 None None None Human 4.3 pIC50 = 4.3 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 428 4 2 4 4.2 COc1ccccc1-c1ccc2c(c1)C(=O)c1ccccc1[C@@H]1[C@H](C(=O)O)[C@H](C(=O)O)[C@H]21 10.1016/0960-894X(95)00230-Q
CHEMBL31524 216649 0 None None None Human 4.3 pIC50 = 4.3 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 428 4 2 4 4.2 COc1ccccc1-c1ccc2c(c1)C(=O)c1ccccc1[C@@H]1[C@H](C(=O)O)[C@H](C(=O)O)[C@H]21 10.1016/0960-894X(95)00230-Q
44277245 216506 0 None None None Rat 4.3 pIC50 = 4.3 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 392 6 1 4 3.9 COc1ccc(Cc2c(C(F)(F)F)[nH]n(Cc3cccc(OC)c3)c2=O)cc1 10.1016/s0960-894x(00)00232-8
CHEMBL3144736 216506 0 None None None Rat 4.3 pIC50 = 4.3 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 392 6 1 4 3.9 COc1ccc(Cc2c(C(F)(F)F)[nH]n(Cc3cccc(OC)c3)c2=O)cc1 10.1016/s0960-894x(00)00232-8
44385522 122402 0 None None None Human 6.3 pIC50 = 6.3 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 642 13 2 11 4.2 CCS(=O)(=O)NCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL172029 122402 0 None None None Human 6.3 pIC50 = 6.3 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 642 13 2 11 4.2 CCS(=O)(=O)NCCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
9808545 25729 0 None None None Human 6.3 pIC50 = 6.3 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 588 11 2 7 5.2 COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 10.1021/jm990171i
CHEMBL1180353 25729 0 None None None Human 6.3 pIC50 = 6.3 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 588 11 2 7 5.2 COCCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 10.1021/jm990171i
10571380 122852 0 None None None Rat 7.3 pIC50 = 7.3 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 373 7 1 4 4.7 Cc1ccccc1C(Oc1cc(OCc2ccccc2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL173838 122852 0 None None None Rat 7.3 pIC50 = 7.3 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 373 7 1 4 4.7 Cc1ccccc1C(Oc1cc(OCc2ccccc2)ccc1C#N)C(=O)O 10.1021/jm990378b
9845967 25373 0 None None None Human 7.3 pIC50 = 7.3 Binding
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 416 7 1 5 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL1178000 25373 0 None None None Human 7.3 pIC50 = 7.3 Binding
Inhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cellsInhibition of Endothelin A receptor mediated (ET-1) release of arachidonic acid from rabbit renal artery vascular smooth muscle cells
ChEMBL 416 7 1 5 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm9606507
CHEMBL433853 488596 0 None None None Pig 7.3 pIC50 = 7.3 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 642 7 7 7 0.9 CC(C)C[C@H]1NC(=O)[C@H](C(C)(C)S)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
44371450 102110 0 None None None Rat 6.3 pIC50 = 6.3 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 485 7 1 7 5.2 COc1ccc(OC)c(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)c1 10.1016/s0960-894x(99)00040-2
CHEMBL155937 102110 0 None None None Rat 6.3 pIC50 = 6.3 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 485 7 1 7 5.2 COc1ccc(OC)c(-c2c(C(=O)O)c(=O)n(Cc3ccccc3OC)c3c2oc2ccccc23)c1 10.1016/s0960-894x(99)00040-2
15453210 470103 0 None None None Human 6.3 pIC50 = 6.3 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 376 5 1 6 2.6 COc1ccc(S(=O)(=O)Nc2onc(C)c2Br)cc1OC 10.1016/0960-894X(96)00441-6
CHEMBL78853 470103 0 None None None Human 6.3 pIC50 = 6.3 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 376 5 1 6 2.6 COc1ccc(S(=O)(=O)Nc2onc(C)c2Br)cc1OC 10.1016/0960-894X(96)00441-6
44316458 470285 1 None None None Human 6.3 pIC50 = 6.3 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 408 3 1 4 3.6 Cc1noc(NS(=O)(=O)c2cc(Br)ccc2Br)c1C 10.1016/0960-894X(96)00441-6
CHEMBL80317 470285 1 None None None Human 6.3 pIC50 = 6.3 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 408 3 1 4 3.6 Cc1noc(NS(=O)(=O)c2cc(Br)ccc2Br)c1C 10.1016/0960-894X(96)00441-6
10404449 199704 0 None None None Rat 5.3 pIC50 = 5.3 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 331 4 1 5 3.0 Cc1cnoc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm00008a013
CHEMBL283300 199704 0 None None None Rat 5.3 pIC50 = 5.3 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 331 4 1 5 3.0 Cc1cnoc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm00008a013
9865706 198427 0 None None None Human 5.3 pIC50 = 5.3 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 400 4 1 5 4.1 Cc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL273613 198427 0 None None None Human 5.3 pIC50 = 5.3 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 400 4 1 5 4.1 Cc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
44385523 123825 0 None None None Human 5.3 pIC50 = 5.3 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 666 13 2 9 5.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL176418 123825 0 None None None Human 5.3 pIC50 = 5.3 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 666 13 2 9 5.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL409777 488082 0 None None None Rat 4.3 pIC50 = 4.3 Binding
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1790 41 24 26 -3.9 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
9957883 198910 0 None None None Human 8.3 pIC50 = 8.3 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 507 7 1 9 5.0 COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00232-6
CHEMBL27732 198910 0 None None None Human 8.3 pIC50 = 8.3 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 507 7 1 9 5.0 COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00232-6
10626031 219259 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 529 13 1 7 2.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1C(=O)CCC1=O 10.1021/jm980217s
CHEMBL322799 219259 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 529 13 1 7 2.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCN1C(=O)CCC1=O 10.1021/jm980217s
10767210 220823 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 484 12 1 4 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2cccc(F)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL326719 220823 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 484 12 1 4 5.1 CCCCN(CCCC)C(=O)CN1C[C@H](c2cccc(F)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
9871837 39101 0 None None None Human 8.3 pIC50 = 8.3 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 535 10 2 7 4.9 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1039/C4MD00499J
CHEMBL12106 39101 0 None None None Human 8.3 pIC50 = 8.3 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 535 10 2 7 4.9 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1039/C4MD00499J
44458650 175857 0 None None None Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 521 7 2 8 2.7 COc1ccccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1016/s0960-894x(01)00660-6
CHEMBL22367 175857 0 None None None Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 521 7 2 8 2.7 COc1ccccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1016/s0960-894x(01)00660-6
10547407 123009 0 None None None Rat 8.3 pIC50 = 8.3 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 374 7 1 5 4.0 Cc1ccccc1C(Oc1cc(OCc2ccncc2)ccc1C#N)C(=O)O 10.1021/jm990378b
10619391 123009 0 None None None Rat 8.3 pIC50 = 8.3 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 374 7 1 5 4.0 Cc1ccccc1C(Oc1cc(OCc2ccncc2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL174092 123009 0 None None None Rat 8.3 pIC50 = 8.3 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 374 7 1 5 4.0 Cc1ccccc1C(Oc1cc(OCc2ccncc2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL2110232 123009 0 None None None Rat 8.3 pIC50 = 8.3 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 374 7 1 5 4.0 Cc1ccccc1C(Oc1cc(OCc2ccncc2)ccc1C#N)C(=O)O 10.1021/jm990378b
10453733 221798 0 None None None Rat 8.3 pIC50 = 8.3 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 402 9 1 5 4.8 Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2cccnc2)ccc1C#N 10.1021/jm9707131
CHEMBL329181 221798 0 None None None Rat 8.3 pIC50 = 8.3 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 402 9 1 5 4.8 Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2cccnc2)ccc1C#N 10.1021/jm9707131
9953204 474325 0 None None None Rat 8.3 pIC50 = 8.3 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 407 9 1 5 5.5 Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C#N 10.1021/jm9707131
CHEMBL94071 474325 0 None None None Rat 8.3 pIC50 = 8.3 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 407 9 1 5 5.5 Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C#N 10.1021/jm9707131
10210086 124041 0 None None None Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 571 10 2 12 3.0 C#CCOc1nc(-c2ccnc(-c3nn[nH]n3)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL176664 124041 0 None None None Human 8.3 pIC50 = 8.3 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 571 10 2 12 3.0 C#CCOc1nc(-c2ccnc(-c3nn[nH]n3)c2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10361107 317546 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 5 2 5 4.1 Cc1noc(NS(=O)(=O)c2cccc3c(NC(C)C)cccc23)c1C 10.1021/jm00004a012
CHEMBL416026 317546 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 5 2 5 4.1 Cc1noc(NS(=O)(=O)c2cccc3c(NC(C)C)cccc23)c1C 10.1021/jm00004a012
CHEMBL64271 489357 0 None None None Pig 8.3 pIC50 = 8.3 Binding
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL 935 22 9 8 3.9 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00349-X
10281929 23697 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 588 16 1 7 5.3 CCCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm970101g
CHEMBL111517 23697 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 588 16 1 7 5.3 CCCCCCCS(=O)(=O)N(CCC)CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm970101g
10553490 354975 0 None None None Human 8.3 pIC50 = 8.3 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 501 8 3 10 2.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2OCCO)OCO3)c1Cl 10.1021/jm9608366
CHEMBL47604 354975 0 None None None Human 8.3 pIC50 = 8.3 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 501 8 3 10 2.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2OCCO)OCO3)c1Cl 10.1021/jm9608366
44386921 124040 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 384 5 1 6 3.8 COC1=C(C(=O)O)[C@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm031041j
CHEMBL176661 124040 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 384 5 1 6 3.8 COC1=C(C(=O)O)[C@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm031041j
10721344 21860 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 548 13 1 8 3.0 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCOC 10.1021/jm970101g
CHEMBL108748 21860 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 548 13 1 8 3.0 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)CCOC 10.1021/jm970101g
10918390 43177 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 522 12 1 5 5.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)cc1 10.1021/jm010237l
CHEMBL129060 43177 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 522 12 1 5 5.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(CC)cc1 10.1021/jm010237l
9807178 461682 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 384 5 1 6 3.8 COC1=C(C(=O)O)[C@@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL63121 461682 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 384 5 1 6 3.8 COC1=C(C(=O)O)[C@@H](c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
10767280 218260 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 486 14 1 5 5.1 C=C(C)CCC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
CHEMBL320763 218260 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 486 14 1 5 5.1 C=C(C)CCC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
44458669 175630 0 None None None Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 505 6 2 7 3.0 Cc1ccccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1016/s0960-894x(01)00660-6
CHEMBL22249 175630 0 None None None Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 505 6 2 7 3.0 Cc1ccccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(N)=O)ccc12 10.1016/s0960-894x(01)00660-6
107810 3461 29 None None None Human 8.3 pIC50 = 8.3 Binding
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 604 12 4 6 3.4 CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccccn1)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C 10.1016/0960-894X(95)00144-I
998 3461 29 None None None Human 8.3 pIC50 = 8.3 Binding
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 604 12 4 6 3.4 CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccccn1)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C 10.1016/0960-894X(95)00144-I
CHEMBL352396 3461 29 None None None Human 8.3 pIC50 = 8.3 Binding
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 604 12 4 6 3.4 CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccccn1)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C 10.1016/0960-894X(95)00144-I
22009947 176292 0 None None None Human 8.3 pIC50 = 8.3 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 536 7 2 8 3.6 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 10.1007/s00044-004-0021-y
9807200 176292 0 None None None Human 8.3 pIC50 = 8.3 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 536 7 2 8 3.6 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261358 176292 0 None None None Human 8.3 pIC50 = 8.3 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 536 7 2 8 3.6 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261359 176292 0 None None None Human 8.3 pIC50 = 8.3 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 536 7 2 8 3.6 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 10.1007/s00044-004-0021-y
9984193 201291 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 521 10 2 8 3.9 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1021/jm031041j
CHEMBL295440 201291 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 521 10 2 8 3.9 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1021/jm031041j
9984193 201291 0 None None None Human 8.3 pIC50 = 8.3 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 521 10 2 8 3.9 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL295440 201291 0 None None None Human 8.3 pIC50 = 8.3 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 521 10 2 8 3.9 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
10649119 25715 0 None None None Human 8.3 pIC50 = 8.3 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 502 8 2 6 4.1 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(C)c2ccccc2)cc1 10.1021/jm990171i
CHEMBL1180318 25715 0 None None None Human 8.3 pIC50 = 8.3 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 502 8 2 6 4.1 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(C)c2ccccc2)cc1 10.1021/jm990171i
73669994 236469 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 429 9 1 7 4.7 N#Cc1ccc(OCc2ccc3nonc3c2)cc1OC(CCC(=O)O)c1ccccc1 10.1016/j.bmc.2015.01.003
CHEMBL3400996 236469 0 None None None Rat 8.3 pIC50 = 8.3 Binding
Displacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry methodDisplacement of [125I]ET-1 from rat ETA receptor after 1 hr by Lowry method
ChEMBL 429 9 1 7 4.7 N#Cc1ccc(OCc2ccc3nonc3c2)cc1OC(CCC(=O)O)c1ccccc1 10.1016/j.bmc.2015.01.003
44283419 200483 0 None None None Pig 8.3 pIC50 = 8.3 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 647 13 5 4 5.1 CCCC[C@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
44314750 200483 0 None None None Pig 8.3 pIC50 = 8.3 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 647 13 5 4 5.1 CCCC[C@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL289349 200483 0 None None None Pig 8.3 pIC50 = 8.3 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 647 13 5 4 5.1 CCCC[C@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL424422 200483 0 None None None Pig 8.3 pIC50 = 8.3 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 647 13 5 4 5.1 CCCC[C@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
10140965 201305 0 None None None Human 8.3 pIC50 = 8.3 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 485 7 3 9 3.0 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CCO)OCO3)c1Cl 10.1021/jm9608366
CHEMBL295588 201305 0 None None None Human 8.3 pIC50 = 8.3 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 485 7 3 9 3.0 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CCO)OCO3)c1Cl 10.1021/jm9608366
44283419 200483 0 None None None Pig 8.3 pIC50 = 8.3 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 647 13 5 4 5.1 CCCC[C@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
44314750 200483 0 None None None Pig 8.3 pIC50 = 8.3 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 647 13 5 4 5.1 CCCC[C@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
CHEMBL289349 200483 0 None None None Pig 8.3 pIC50 = 8.3 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 647 13 5 4 5.1 CCCC[C@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
CHEMBL424422 200483 0 None None None Pig 8.3 pIC50 = 8.3 Binding
Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 647 13 5 4 5.1 CCCC[C@H](NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1016/0960-894X(95)00237-N
44314905 469913 0 None None None Pig 8.2 pIC50 = 8.2 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 567 12 5 4 4.0 CCCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
CHEMBL77083 469913 0 None None None Pig 8.2 pIC50 = 8.2 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 567 12 5 4 4.0 CCCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
44333867 18986 0 None None None Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 403 4 1 5 4.1 COc1ccc([C@@H]2c3nc(C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
CHEMBL103001 18986 0 None None None Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 403 4 1 5 4.1 COc1ccc([C@@H]2c3nc(C)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1016/s0960-894x(02)00663-7
10415822 257735 0 None None None Rat 8.2 pIC50 = 8.2 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 579 9 3 7 4.7 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCOC23CCCCC3)nc1C(=O)O 10.1021/jm950592+
CHEMBL367551 257735 0 None None None Rat 8.2 pIC50 = 8.2 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 579 9 3 7 4.7 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCOC23CCCCC3)nc1C(=O)O 10.1021/jm950592+
11798998 473776 0 None None None Rat 8.2 pIC50 = 8.2 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 482 10 1 6 3.9 CCCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9050 473776 0 None None None Rat 8.2 pIC50 = 8.2 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 482 10 1 6 3.9 CCCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
122272 197418 36 None None None Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1016/0960-894X(96)00441-6
CHEMBL267458 197418 36 None None None Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1016/0960-894X(96)00441-6
10415348 123849 0 None None None Rat 8.2 pIC50 = 8.2 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 557 9 3 6 4.8 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCc3ccccc32)nc1C(=O)O 10.1021/jm950592+
CHEMBL176514 123849 0 None None None Rat 8.2 pIC50 = 8.2 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 557 9 3 6 4.8 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCc3ccccc32)nc1C(=O)O 10.1021/jm950592+
CHEMBL438733 488736 0 None None None Pig 8.2 pIC50 = 8.2 Binding
Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorTested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptor
ChEMBL 2490 63 32 36 -4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]2CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N2)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00077a013
10647642 22416 0 None None None Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 460 6 2 7 3.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(C(=O)O)c2)cc1 10.1021/jm9606507
CHEMBL10915 22416 0 None None None Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 460 6 2 7 3.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc(C(=O)O)c2)cc1 10.1021/jm9606507
11799625 232826 0 None None None Human 7.3 pIC50 = 7.3 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2ccc(C)c(C)c2)cc1 10.1021/jm990170q
CHEMBL332431 232826 0 None None None Human 7.3 pIC50 = 7.3 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 502 7 2 6 4.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2ccc(C)c(C)c2)cc1 10.1021/jm990170q
9871561 348836 0 None None None Human 7.3 pIC50 = 7.3 Binding
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 527 10 2 8 4.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cc2)nc(C(F)(F)F)nc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL4562189 348836 0 None None None Human 7.3 pIC50 = 7.3 Binding
Displacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cellsDisplacement of 125I-ET1 from human placenta cell membrane ETA receptor expressed in Baculovirus-infected insect cells
ChEMBL 527 10 2 8 4.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cc2)nc(C(F)(F)F)nc1OCCO 10.1016/j.bmcl.2016.06.014
9873255 122410 0 None None None Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 591 14 2 10 3.8 CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL172071 122410 0 None None None Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 591 14 2 10 3.8 CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
122272 197418 36 None None None Human 7.3 pIC50 = 7.3 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm9604585
CHEMBL267458 197418 36 None None None Human 7.3 pIC50 = 7.3 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm9604585
10553017 198401 0 None None None Rat 7.3 pIC50 = 7.3 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 488 7 1 6 3.9 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)c2ccccc2)cc1 10.1021/jm9505369
CHEMBL273476 198401 0 None None None Rat 7.3 pIC50 = 7.3 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 488 7 1 6 3.9 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)c2ccccc2)cc1 10.1021/jm9505369
10502023 240966 0 None None None Rat 6.3 pIC50 = 6.3 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 416 7 1 5 4.4 COc1cccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)c1 10.1021/jm031041j
CHEMBL360066 240966 0 None None None Rat 6.3 pIC50 = 6.3 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 416 7 1 5 4.4 COc1cccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)c1 10.1021/jm031041j
CHEMBL384728 487646 0 None None None Human 6.3 pIC50 = 6.3 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 972 25 9 8 5.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
3370402 215481 1 None None None Human 6.3 pIC50 = 6.3 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 252 3 1 4 2.1 Cc1noc(NS(=O)(=O)c2ccccc2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL312670 215481 1 None None None Human 6.3 pIC50 = 6.3 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 252 3 1 4 2.1 Cc1noc(NS(=O)(=O)c2ccccc2)c1C 10.1016/0960-894X(96)00441-6
10740614 198590 0 None None None Human 6.3 pIC50 = 6.3 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 416 5 1 6 3.8 COc1cccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)c1 10.1021/jm9606507
CHEMBL274857 198590 0 None None None Human 6.3 pIC50 = 6.3 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 416 5 1 6 3.8 COc1cccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)c1 10.1021/jm9606507
10714851 221413 0 None None None Rat 6.3 pIC50 = 6.3 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 381 7 1 5 4.9 O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1[N+](=O)[O-])c1ccccc1 10.1021/jm970847e
CHEMBL328786 221413 0 None None None Rat 6.3 pIC50 = 6.3 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 381 7 1 5 4.9 O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1[N+](=O)[O-])c1ccccc1 10.1021/jm970847e
44211959 118263 0 None None None Human 6.3 pIC50 = 6.3 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 620 12 1 9 5.5 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(C)(=O)=O)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL16197 118263 0 None None None Human 6.3 pIC50 = 6.3 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 620 12 1 9 5.5 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(C)(=O)=O)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
44368480 97894 0 None None None Pig 5.3 pIC50 = 5.3 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 495 13 1 7 4.4 COc1ccc(CC(C(=O)O)N(Cc2ccc(OC)cc2)Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/s0960-894x(01)00009-9
CHEMBL152034 97894 0 None None None Pig 5.3 pIC50 = 5.3 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 495 13 1 7 4.4 COc1ccc(CC(C(=O)O)N(Cc2ccc(OC)cc2)Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1016/s0960-894x(01)00009-9
10017402 201999 1 None None None Rat 5.3 pIC50 = 5.3 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 295 5 2 5 2.5 CCNc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm00008a013
CHEMBL30078 201999 1 None None None Rat 5.3 pIC50 = 5.3 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 295 5 2 5 2.5 CCNc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm00008a013
44328057 197218 0 None None None Human 5.3 pIC50 = 5.3 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 986 26 9 9 4.9 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1cccnc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL265734 197218 0 None None None Human 5.3 pIC50 = 5.3 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 986 26 9 9 4.9 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1cccnc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL2370253 485550 0 None None None Human 5.3 pIC50 = 5.3 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 884 25 8 8 3.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
44279351 200124 0 None None None Human 5.3 pIC50 = 5.3 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 412 3 2 3 4.5 Cc1ccccc1-c1ccc2c(c1)C(=O)c1ccccc1[C@@H]1[C@H](C(=O)O)[C@H](C(=O)O)[C@H]21 10.1016/0960-894X(95)00230-Q
CHEMBL286333 200124 0 None None None Human 5.3 pIC50 = 5.3 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 412 3 2 3 4.5 Cc1ccccc1-c1ccc2c(c1)C(=O)c1ccccc1[C@@H]1[C@H](C(=O)O)[C@H](C(=O)O)[C@H]21 10.1016/0960-894X(95)00230-Q
31771 197290 38 None None None Rat 5.3 pIC50 = 5.3 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 267 3 2 5 1.7 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/s0960-894x(00)00366-8
CHEMBL26630 197290 38 None None None Rat 5.3 pIC50 = 5.3 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 267 3 2 5 1.7 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/s0960-894x(00)00366-8
10017402 201999 1 None None None Rat 5.3 pIC50 = 5.3 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 295 5 2 5 2.5 CCNc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm00004a012
CHEMBL30078 201999 1 None None None Rat 5.3 pIC50 = 5.3 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 295 5 2 5 2.5 CCNc1ccc(S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm00004a012
10454873 196765 0 None None None Rat 4.3 pIC50 = 4.3 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 421 6 1 5 4.6 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1Cc1ccccc1 10.1021/jm00008a013
CHEMBL26203 196765 0 None None None Rat 4.3 pIC50 = 4.3 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 421 6 1 5 4.6 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1Cc1ccccc1 10.1021/jm00008a013
44383536 239050 0 None None None Human 4.3 pIC50 = 4.3 Binding
Tested for binding affinity towards rabbit Endothelin A receptorTested for binding affinity towards rabbit Endothelin A receptor
ChEMBL 362 3 2 5 2.9 C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(O)[C@]2(O)[C@@]2(C)CCCC(C)(C)C12 10.1016/s0960-894x(00)00136-0
CHEMBL353502 239050 0 None None None Human 4.3 pIC50 = 4.3 Binding
Tested for binding affinity towards rabbit Endothelin A receptorTested for binding affinity towards rabbit Endothelin A receptor
ChEMBL 362 3 2 5 2.9 C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(O)[C@]2(O)[C@@]2(C)CCCC(C)(C)C12 10.1016/s0960-894x(00)00136-0
10671298 468466 0 None None None Human 6.3 pIC50 = 6.3 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 450 6 1 6 3.7 CCOc1nc(Br)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
CHEMBL6588 468466 0 None None None Human 6.3 pIC50 = 6.3 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 450 6 1 6 3.7 CCOc1nc(Br)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
10789830 197341 0 None None None Human 5.3 pIC50 = 5.3 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 453 4 1 4 3.7 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(I)cn3)cccc12 10.1021/jm9604585
CHEMBL266684 197341 0 None None None Human 5.3 pIC50 = 5.3 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 453 4 1 4 3.7 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(I)cn3)cccc12 10.1021/jm9604585
10740942 468548 0 None None None Human 5.3 pIC50 = 5.3 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 422 4 2 6 3.0 CN(C)c1cccc2c(S(=O)(=O)Nc3ncc(Br)nc3O)cccc12 10.1021/jm9604585
CHEMBL6647 468548 0 None None None Human 5.3 pIC50 = 5.3 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 422 4 2 6 3.0 CN(C)c1cccc2c(S(=O)(=O)Nc3ncc(Br)nc3O)cccc12 10.1021/jm9604585
10595728 468557 0 None None None Human 5.3 pIC50 = 5.3 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 376 4 1 5 3.5 Cc1cc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nnc1Cl 10.1021/jm9604585
CHEMBL6660 468557 0 None None None Human 5.3 pIC50 = 5.3 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 376 4 1 5 3.5 Cc1cc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)nnc1Cl 10.1021/jm9604585
10644647 239143 0 None None None Rat 6.3 pIC50 = 6.3 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 399 7 1 5 5.1 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccc(Cl)cc1 10.1021/jm990378b
CHEMBL354428 239143 0 None None None Rat 6.3 pIC50 = 6.3 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 399 7 1 5 5.1 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccc(Cl)cc1 10.1021/jm990378b
9845562 19081 0 None None None Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(C)cc2)cc1 10.1021/jm9606507
CHEMBL10374 19081 0 None None None Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 430 5 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(C)cc2)cc1 10.1021/jm9606507
44279535 213855 0 None None None Pig 7.3 pIC50 = 7.3 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 527 11 5 4 3.2 CC(C)C[C@H](NC(=O)N1C(C)CCCC1C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL30944 213855 0 None None None Pig 7.3 pIC50 = 7.3 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 527 11 5 4 3.2 CC(C)C[C@H](NC(=O)N1C(C)CCCC1C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
44314675 198421 0 None None None Pig 7.3 pIC50 = 7.3 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 603 13 5 4 5.0 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)CC)C(=O)O 10.1021/jm9600914
CHEMBL273583 198421 0 None None None Pig 7.3 pIC50 = 7.3 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 603 13 5 4 5.0 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)CC)C(=O)O 10.1021/jm9600914
CHEMBL2304005 485307 0 None None None Pig 7.3 pIC50 = 7.3 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 624 7 6 6 1.1 Cc1[nH]c2ccccc2c1C[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC1=O 10.1021/jm9600914
9955093 331128 0 None None None Rat 7.3 pIC50 = 7.3 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 443 7 1 5 5.2 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccccc1Br 10.1021/jm990378b
CHEMBL427117 331128 0 None None None Rat 7.3 pIC50 = 7.3 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 443 7 1 5 5.2 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccccc1Br 10.1021/jm990378b
10281606 257590 0 None None None Human 7.3 pIC50 = 7.3 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 575 9 2 10 4.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL367382 257590 0 None None None Human 7.3 pIC50 = 7.3 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 575 9 2 10 4.2 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
9809270 259229 0 None None None Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 622 14 2 12 2.3 CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL368738 259229 0 None None None Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 622 14 2 12 2.3 CCCS(=O)(=O)NCCOc1nc(N2CCOCC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
10896930 24125 0 None None None Pig 7.3 pIC50 = 7.3 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 11 1 10 4.6 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2cccnn2)c1 10.1021/jm0102304
CHEMBL113888 24125 0 None None None Pig 7.3 pIC50 = 7.3 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 11 1 10 4.6 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2cccnn2)c1 10.1021/jm0102304
44373550 238561 0 None None None Rat 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 331 3 2 5 2.1 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1Br 10.1021/jm00004a012
CHEMBL348641 238561 0 None None None Rat 6.3 pIC50 = 6.3 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 331 3 2 5 2.1 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1Br 10.1021/jm00004a012
10647182 219282 0 None None None Rat 5.3 pIC50 = 5.3 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 449 8 2 4 3.9 CCCN(C)C(=O)CN1C[C@H](c2ccc3cc[nH]c3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL322935 219282 0 None None None Rat 5.3 pIC50 = 5.3 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 449 8 2 4 3.9 CCCN(C)C(=O)CN1C[C@H](c2ccc3cc[nH]c3c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
10579195 259228 0 None None None Rat 4.3 pIC50 = 4.3 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 584 10 5 4 5.7 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(-c2ccccc2)[nH]1 10.1021/jm950591h
CHEMBL368711 259228 0 None None None Rat 4.3 pIC50 = 4.3 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 584 10 5 4 5.7 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(-c2ccccc2)[nH]1 10.1021/jm950591h
10531664 333216 0 None None None Rat 4.3 pIC50 = 4.3 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 601 10 4 5 6.4 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(-c2ccccc2)s1 10.1021/jm950591h
CHEMBL435537 333216 0 None None None Rat 4.3 pIC50 = 4.3 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 601 10 4 5 6.4 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(-c2ccccc2)s1 10.1021/jm950591h
9897092 122713 0 None None None Human 5.3 pIC50 = 5.3 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 779 17 2 13 6.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL173201 122713 0 None None None Human 5.3 pIC50 = 5.3 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 779 17 2 13 6.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2cc(OC)c(OC)c(OC)c2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
23445523 122797 0 None None None Human 6.3 pIC50 = 6.3 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 472 6 1 8 3.9 Cc1noc(NS(=O)(=O)c2sccc2COc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00132-7
CHEMBL173557 122797 0 None None None Human 6.3 pIC50 = 6.3 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 472 6 1 8 3.9 Cc1noc(NS(=O)(=O)c2sccc2COc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00132-7
9961347 26235 1 None None None Human 4.3 pIC50 = 4.3 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 664 13 2 7 6.6 Cc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C 10.1021/jm990171i
CHEMBL1182945 26235 1 None None None Human 4.3 pIC50 = 4.3 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 664 13 2 7 6.6 Cc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C 10.1021/jm990171i
10764220 474008 0 None None None Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 413 8 1 6 3.3 CCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9189 474008 0 None None None Rat 6.3 pIC50 = 6.3 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 413 8 1 6 3.3 CCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10907399 468014 0 None None None Rat 5.3 pIC50 = 5.3 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 516 11 1 6 6.8 CCCCOc1ccc(C2Oc3ccc(OCCCC)cc3C(c3ccc4c(c3)OCO4)=C2C(=O)O)cc1 10.1021/jm010382z
CHEMBL62976 468014 0 None None None Rat 5.3 pIC50 = 5.3 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 516 11 1 6 6.8 CCCCOc1ccc(C2Oc3ccc(OCCCC)cc3C(c3ccc4c(c3)OCO4)=C2C(=O)O)cc1 10.1021/jm010382z
10745212 259429 0 None None None Rat 5.3 pIC50 = 5.3 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 548 10 5 4 4.9 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C2CC2)[nH]1 10.1021/jm950591h
CHEMBL369257 259429 0 None None None Rat 5.3 pIC50 = 5.3 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 548 10 5 4 4.9 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C2CC2)[nH]1 10.1021/jm950591h
10550844 197619 0 None None None Rat 5.3 pIC50 = 5.3 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 435 5 1 6 3.7 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)c2ccco2)cc1 10.1021/jm9505369
CHEMBL269140 197619 0 None None None Rat 5.3 pIC50 = 5.3 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 435 5 1 6 3.7 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2C(=O)c2ccco2)cc1 10.1021/jm9505369
10548721 122436 0 None None None Rat 6.3 pIC50 = 6.3 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 395 8 1 6 4.4 COc1ccccc1C(Oc1cc(OCc2ccsc2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL172164 122436 0 None None None Rat 6.3 pIC50 = 6.3 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 395 8 1 6 4.4 COc1ccccc1C(Oc1cc(OCc2ccsc2)ccc1C#N)C(=O)O 10.1021/jm990378b
44316768 470100 0 None None None Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 358 4 1 4 3.4 CCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C 10.1016/0960-894X(96)00441-6
CHEMBL78830 470100 0 None None None Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 358 4 1 4 3.4 CCc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C 10.1016/0960-894X(96)00441-6
44279458 199907 0 None None None Pig 7.3 pIC50 = 7.3 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 531 13 6 5 2.0 CC(C)C[C@H](NC(=O)N(CCO)C(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL284785 199907 0 None None None Pig 7.3 pIC50 = 7.3 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 531 13 6 5 2.0 CC(C)C[C@H](NC(=O)N(CCO)C(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
9910709 122127 0 None None None Rat 7.3 pIC50 = 7.3 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 433 7 1 5 5.4 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccccc1C(F)(F)F 10.1021/jm990378b
CHEMBL170715 122127 0 None None None Rat 7.3 pIC50 = 7.3 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 433 7 1 5 5.4 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccccc1C(F)(F)F 10.1021/jm990378b
10144372 330905 0 None None None Human 7.3 pIC50 = 7.3 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 562 10 2 11 3.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ncccn2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL425682 330905 0 None None None Human 7.3 pIC50 = 7.3 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 562 10 2 11 3.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ncccn2)nc1OCC#CCO 10.1016/s0960-894x(02)01084-3
10344511 122461 0 None None None Human 7.3 pIC50 = 7.3 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 466 5 1 5 5.7 Cc1cc(C)c(/C=C/c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL172248 122461 0 None None None Human 7.3 pIC50 = 7.3 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 466 5 1 5 5.7 Cc1cc(C)c(/C=C/c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
44279290 216681 0 None None None Pig 6.3 pIC50 = 6.3 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 547 11 5 4 3.0 CC(C)C[C@H](NC(=O)N1CCc2ccccc2C1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31546 216681 0 None None None Pig 6.3 pIC50 = 6.3 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 547 11 5 4 3.0 CC(C)C[C@H](NC(=O)N1CCc2ccccc2C1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
10971076 467937 0 None None None Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 386 3 1 4 4.7 Cc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)cc1 10.1021/jm010382z
CHEMBL62585 467937 0 None None None Rat 6.3 pIC50 = 6.3 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 386 3 1 4 4.7 Cc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)cc1 10.1021/jm010382z
44279128 216568 0 None None None Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 428 4 2 4 4.2 COc1ccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)cc1 10.1016/0960-894X(95)00230-Q
CHEMBL31469 216568 0 None None None Human 6.3 pIC50 = 6.3 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 428 4 2 4 4.2 COc1ccc(-c2ccc3c(c2)C(=O)c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@H]32)cc1 10.1016/0960-894X(95)00230-Q
44298393 443647 0 None None None Rat 6.3 pIC50 = 6.3 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 432 6 1 6 5.2 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2C)c1 10.1016/s0960-894x(00)00366-8
CHEMBL59425 443647 0 None None None Rat 6.3 pIC50 = 6.3 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 432 6 1 6 5.2 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2C)c1 10.1016/s0960-894x(00)00366-8
CHEMBL136583 484662 0 None None None Pig 6.3 pIC50 = 6.3 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 612 8 7 6 1.0 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10546317 474081 0 None None None Rat 5.3 pIC50 = 5.3 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 358 8 1 2 5.7 O=C(O)CC/C(=C/c1cccc(OCc2ccccc2)c1)c1ccccc1 10.1021/jm970847e
CHEMBL92402 474081 0 None None None Rat 5.3 pIC50 = 5.3 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 358 8 1 2 5.7 O=C(O)CC/C(=C/c1cccc(OCc2ccccc2)c1)c1ccccc1 10.1021/jm970847e
10106336 198205 5 None None None Rat 4.3 pIC50 = 4.3 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 254 3 2 5 1.5 Cc1cc(NS(=O)(=O)c2ccc(O)cc2)no1 10.1021/jm00008a013
CHEMBL27248 198205 5 None None None Rat 4.3 pIC50 = 4.3 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 254 3 2 5 1.5 Cc1cc(NS(=O)(=O)c2ccc(O)cc2)no1 10.1021/jm00008a013
18617394 215321 0 None None None Human 4.3 pIC50 = 4.3 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 294 3 1 4 3.0 Cc1cc(C)c(S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1016/0960-894X(96)00441-6
CHEMBL312372 215321 0 None None None Human 4.3 pIC50 = 4.3 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 294 3 1 4 3.0 Cc1cc(C)c(S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1016/0960-894X(96)00441-6
10106336 198205 5 None None None Rat 4.3 pIC50 = 4.3 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 254 3 2 5 1.5 Cc1cc(NS(=O)(=O)c2ccc(O)cc2)no1 10.1021/jm00004a012
CHEMBL27248 198205 5 None None None Rat 4.3 pIC50 = 4.3 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 254 3 2 5 1.5 Cc1cc(NS(=O)(=O)c2ccc(O)cc2)no1 10.1021/jm00004a012
10815167 201326 0 None None None Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 497 7 2 6 5.4 CCC(C)c1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9608366
CHEMBL295697 201326 0 None None None Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 497 7 2 6 5.4 CCC(C)c1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1021/jm9608366
23445313 330511 0 None None None Human 7.3 pIC50 = 7.3 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 470 6 1 6 5.1 Cc1cc(C)c(OCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00132-7
CHEMBL424371 330511 0 None None None Human 7.3 pIC50 = 7.3 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 470 6 1 6 5.1 Cc1cc(C)c(OCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00132-7
44279516 200038 0 None None None Pig 6.3 pIC50 = 6.3 Binding
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 512 13 5 5 2.6 CC(C)C[C@H](NC(=O)Cc1cccs1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL285729 200038 0 None None None Pig 6.3 pIC50 = 6.3 Binding
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 512 13 5 5 2.6 CC(C)C[C@H](NC(=O)Cc1cccs1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL96822 489422 0 None None None Human 6.3 pIC50 = 6.3 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 959 26 9 9 3.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NS(C)(=O)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10426645 328080 0 None None None Rat 5.3 pIC50 = 5.3 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 328 4 1 4 3.8 Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1C 10.1021/jm00008a013
CHEMBL417651 328080 0 None None None Rat 5.3 pIC50 = 5.3 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 328 4 1 4 3.8 Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1C 10.1021/jm00008a013
44291602 201313 0 None None None Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 515 8 2 10 3.6 COC(=O)c1cc(OC)cc(OC)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm9608366
CHEMBL295632 201313 0 None None None Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 515 8 2 10 3.6 COC(=O)c1cc(OC)cc(OC)c1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl 10.1021/jm9608366
44279409 200046 0 None None None Pig 7.3 pIC50 = 7.3 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 555 11 5 4 4.0 CC(C)C[C@H](NC(=O)N1CCCCCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL285782 200046 0 None None None Pig 7.3 pIC50 = 7.3 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 555 11 5 4 4.0 CC(C)C[C@H](NC(=O)N1CCCCCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
23445533 123179 0 None None None Human 7.3 pIC50 = 7.3 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 454 6 1 5 5.0 Cc1ccc(CCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL175045 123179 0 None None None Human 7.3 pIC50 = 7.3 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 454 6 1 5 5.0 Cc1ccc(CCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
18617354 470318 0 None None None Human 6.3 pIC50 = 6.3 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 384 3 1 4 3.9 Cc1noc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL80507 470318 0 None None None Human 6.3 pIC50 = 6.3 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 384 3 1 4 3.9 Cc1noc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1Br 10.1016/0960-894X(96)00441-6
23445445 202720 0 None None None Human 6.3 pIC50 = 6.3 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 377 5 2 6 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1C 10.1016/S0960-894X(97)00367-3
CHEMBL304481 202720 0 None None None Human 6.3 pIC50 = 6.3 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 377 5 2 6 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccccc2)c1C 10.1016/S0960-894X(97)00367-3
127034917 273970 0 None None None Human 5.3 pIC50 = 5.3 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 654 12 2 8 6.2 CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3736507 273970 0 None None None Human 5.3 pIC50 = 5.3 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 654 12 2 8 6.2 CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
44266628 19105 0 None None None Human 5.3 pIC50 = 5.3 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 417 5 1 6 4.7 COc1cccc(-c2c(C(=O)O)n(-c3ccc4c(c3)OCO4)c3ccc(OC)cc23)c1 10.1016/0960-894X(96)00170-9
CHEMBL10388 19105 0 None None None Human 5.3 pIC50 = 5.3 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 417 5 1 6 4.7 COc1cccc(-c2c(C(=O)O)n(-c3ccc4c(c3)OCO4)c3ccc(OC)cc23)c1 10.1016/0960-894X(96)00170-9
127035545 273815 0 None None None Human 4.3 pIC50 = 4.3 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 721 14 2 9 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3734955 273815 0 None None None Human 4.3 pIC50 = 4.3 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 721 14 2 9 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(OC)c(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
11797486 26314 1 None None None Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 442 6 2 8 3.5 Cc1noc(NS(=O)(=O)c2ccsc2C(O)Cc2ccc3c(c2)OCO3)c1Cl 10.1021/jm9700068
CHEMBL1183448 26314 1 None None None Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 442 6 2 8 3.5 Cc1noc(NS(=O)(=O)c2ccsc2C(O)Cc2ccc3c(c2)OCO3)c1Cl 10.1021/jm9700068
44279325 221119 0 None None None Pig 6.3 pIC50 = 6.3 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 501 12 6 4 2.5 CC(C)C[C@H](NC(=O)NCC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL32845 221119 0 None None None Pig 6.3 pIC50 = 6.3 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 501 12 6 4 2.5 CC(C)C[C@H](NC(=O)NCC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
76326542 176290 0 None None None Human 6.3 pIC50 = 6.3 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 504 7 1 6 5.2 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccccc21 10.1007/s00044-004-0021-y
CHEMBL2261356 176290 0 None None None Human 6.3 pIC50 = 6.3 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 504 7 1 6 5.2 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccccc21 10.1007/s00044-004-0021-y
10337624 200274 0 None None None Rat 5.3 pIC50 = 5.3 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3ccc(N(C)C)cc23)c1C 10.1021/jm00008a013
CHEMBL287451 200274 0 None None None Rat 5.3 pIC50 = 5.3 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3ccc(N(C)C)cc23)c1C 10.1021/jm00008a013
15340616 216493 0 None None None Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 420 4 1 6 3.3 O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1ccc2c(c1)OCO2 10.1016/s0960-894x(00)00232-8
CHEMBL3144602 216493 0 None None None Rat 5.3 pIC50 = 5.3 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 420 4 1 6 3.3 O=c1c(Cc2ccc3c(c2)OCO3)c(C(F)(F)F)[nH]n1Cc1ccc2c(c1)OCO2 10.1016/s0960-894x(00)00232-8
10337624 200274 0 None None None Rat 5.3 pIC50 = 5.3 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3ccc(N(C)C)cc23)c1C 10.1021/jm00004a012
CHEMBL287451 200274 0 None None None Rat 5.3 pIC50 = 5.3 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3ccc(N(C)C)cc23)c1C 10.1021/jm00004a012
CHEMBL137011 484665 0 None None None Pig 5.3 pIC50 = 5.3 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 624 7 7 6 1.3 CC(C)[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC2CCCCC2)NC1=O 10.1021/jm00021a021
127034757 273840 0 None None None Human 4.3 pIC50 = 4.3 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 679 12 2 7 7.5 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735265 273840 0 None None None Human 4.3 pIC50 = 4.3 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 679 12 2 7 7.5 CCCc1nc2c(C)cc(C(=O)NCCc3ccc(F)cc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
10185233 122838 0 None None None Human 6.3 pIC50 = 6.3 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 497 8 2 8 3.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCC#CCO 10.1016/s0960-894x(02)01084-3
CHEMBL173721 122838 0 None None None Human 6.3 pIC50 = 6.3 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 497 8 2 8 3.8 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCC#CCO 10.1016/s0960-894x(02)01084-3
44279145 220074 0 None None None Pig 7.2 pIC50 = 7.2 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 515 13 5 4 3.0 CC(C)C[C@H](NC(=O)N(C(C)C)C(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL32518 220074 0 None None None Pig 7.2 pIC50 = 7.2 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 515 13 5 4 3.0 CC(C)C[C@H](NC(=O)N(C(C)C)C(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
44295097 38665 0 None None None Rat 7.2 pIC50 = 7.2 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 604 13 1 9 7.0 COc1ccc(C(=O)/C(Cc2cc(OC(C)C)c(OC(C)C)c(OC(C)C)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1206461 38665 0 None None None Rat 7.2 pIC50 = 7.2 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 604 13 1 9 7.0 COc1ccc(C(=O)/C(Cc2cc(OC(C)C)c(OC(C)C)c(OC(C)C)c2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
10621170 25520 0 None None None Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 402 5 2 8 3.0 Cc1cc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)no1 10.1021/jm9608366
CHEMBL1178890 25520 0 None None None Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 402 5 2 8 3.0 Cc1cc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)no1 10.1021/jm9608366
CHEMBL149091 484701 0 None None None Mouse 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL 805 22 9 8 1.6 CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
10549815 124372 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 416 8 1 4 5.0 COc1ccc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc(C)cc2)cc1 10.1021/jm031041j
CHEMBL177123 124372 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 416 8 1 4 5.0 COc1ccc(C/C(C(=O)c2ccc(OC)cc2)=C(/C(=O)O)c2ccc(C)cc2)cc1 10.1021/jm031041j
10047521 22943 0 None None None Human 6.2 pIC50 = 6.2 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 416 6 1 5 4.4 COc1ccc(CC2=C(c3ccc(C)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
CHEMBL10951 22943 0 None None None Human 6.2 pIC50 = 6.2 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 416 6 1 5 4.4 COc1ccc(CC2=C(c3ccc(C)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
10815883 122361 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 522 9 5 4 4.3 Cc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
CHEMBL171855 122361 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 522 9 5 4 4.3 Cc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
10815883 122361 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 522 9 5 4 4.3 Cc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL171855 122361 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 522 9 5 4 4.3 Cc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
10043017 199494 0 None None None Human 5.2 pIC50 = 5.2 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 342 4 1 4 4.3 C=C(C)c1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00029a001
CHEMBL281942 199494 0 None None None Human 5.2 pIC50 = 5.2 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 342 4 1 4 4.3 C=C(C)c1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00029a001
10043017 199494 0 None None None Rat 5.2 pIC50 = 5.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 342 4 1 4 4.3 C=C(C)c1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
CHEMBL281942 199494 0 None None None Rat 5.2 pIC50 = 5.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 342 4 1 4 4.3 C=C(C)c1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
234762 200182 29 None None None Rat 4.2 pIC50 = 4.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 256 3 2 6 0.9 Nc1ccc(S(=O)(=O)Nc2nncs2)cc1 10.1021/jm00008a013
CHEMBL286737 200182 29 None None None Rat 4.2 pIC50 = 4.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 256 3 2 6 0.9 Nc1ccc(S(=O)(=O)Nc2nncs2)cc1 10.1021/jm00008a013
44332807 216872 0 None None None Human 4.2 pIC50 = 4.2 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 447 5 0 5 6.0 O=C(OCc1ccccc1)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL316792 216872 0 None None None Human 4.2 pIC50 = 4.2 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 447 5 0 5 6.0 O=C(OCc1ccccc1)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
10649086 349266 0 None None None Human 6.2 pIC50 = 6.2 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 500 5 3 8 4.0 Cc1noc(NS(=O)(=O)c2ccsc2NC(=O)Nc2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
CHEMBL45723 349266 0 None None None Human 6.2 pIC50 = 6.2 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 500 5 3 8 4.0 Cc1noc(NS(=O)(=O)c2ccsc2NC(=O)Nc2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
18995998 317883 0 None None None Human 7.2 pIC50 = 7.2 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 523 9 1 9 5.3 COc1cccc(Sc2c(C(=O)O)n(Cc3cc(OC)c4c(c3)OCO4)c3cc(OC)c(OC)cc23)c1 10.1016/0960-894X(96)00232-6
CHEMBL416570 317883 0 None None None Human 7.2 pIC50 = 7.2 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 523 9 1 9 5.3 COc1cccc(Sc2c(C(=O)O)n(Cc3cc(OC)c4c(c3)OCO4)c3cc(OC)c(OC)cc23)c1 10.1016/0960-894X(96)00232-6
44293631 332567 0 None None None Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 463 7 2 7 4.1 CCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL430572 332567 0 None None None Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 463 7 2 7 4.1 CCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL328942 486724 0 None None None Human 7.2 pIC50 = 7.2 Binding
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 923 25 9 8 4.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm970161m
44265858 332362 0 None None None Rat 7.2 pIC50 = 7.2 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 509 12 1 6 4.1 CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(N)=O)C1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL430084 332362 0 None None None Rat 7.2 pIC50 = 7.2 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 509 12 1 6 4.1 CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(N)=O)C1c1ccc(OC)cc1 10.1021/jm9505369
44386144 124734 0 None None None Rat 7.2 pIC50 = 7.2 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 555 9 3 7 5.2 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)n2ccc3ccccc32)nc1C(=O)O 10.1021/jm950592+
CHEMBL177431 124734 0 None None None Rat 7.2 pIC50 = 7.2 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 555 9 3 7 5.2 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)n2ccc3ccccc32)nc1C(=O)O 10.1021/jm950592+
23445336 122948 0 None None None Human 7.2 pIC50 = 7.2 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 468 6 1 5 5.3 Cc1cc(C)c(CCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL173977 122948 0 None None None Human 7.2 pIC50 = 7.2 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 468 6 1 5 5.3 Cc1cc(C)c(CCc2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL2370070 485516 0 None None None Human 6.2 pIC50 = 6.2 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 848 25 10 9 1.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL216082 485166 0 None None None Human 6.2 pIC50 = 6.2 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 956 25 8 7 5.9 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10426645 328080 0 None None None Human 6.2 pIC50 = 6.2 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 328 4 1 4 3.8 Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL417651 328080 0 None None None Human 6.2 pIC50 = 6.2 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 328 4 1 4 3.8 Cc1noc(NS(=O)(=O)c2cccc(-c3ccccc3)c2)c1C 10.1016/0960-894X(96)00441-6
44279333 215898 0 None None None Pig 6.2 pIC50 = 6.2 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 513 11 5 4 2.6 CC(C)C[C@H](NC(=O)N1CCC(C)CC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31388 215898 0 None None None Pig 6.2 pIC50 = 6.2 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 513 11 5 4 2.6 CC(C)C[C@H](NC(=O)N1CCC(C)CC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
44294580 38541 0 None None None Rat 6.2 pIC50 = 6.2 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 502 8 1 7 5.8 COc1ccc(C(=O)/C(Cc2ccc(OC(C)(C)C)cc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1205104 38541 0 None None None Rat 6.2 pIC50 = 6.2 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 502 8 1 7 5.8 COc1ccc(C(=O)/C(Cc2ccc(OC(C)(C)C)cc2)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
127034916 273844 0 None None None Human 5.2 pIC50 = 5.2 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 668 12 2 8 6.6 CCCc1nc2c(C)cc(C(=O)NCCN3CCCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735302 273844 0 None None None Human 5.2 pIC50 = 5.2 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 668 12 2 8 6.6 CCCc1nc2c(C)cc(C(=O)NCCN3CCCCC3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL432091 488583 0 None None None Rat 4.2 pIC50 = 4.2 Binding
Compound was evaluated for the binding affinity to endothelin receptor in the rat heart ventricle.Compound was evaluated for the binding affinity to endothelin receptor in the rat heart ventricle.
ChEMBL 837 24 10 9 1.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00087a001
44384723 258778 0 None None None Human 6.2 pIC50 = 6.2 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 563 13 2 10 3.0 CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL368528 258778 0 None None None Human 6.2 pIC50 = 6.2 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 563 13 2 10 3.0 CCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
9853025 122595 0 None None None Human 6.2 pIC50 = 6.2 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 690 14 2 13 3.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL172759 122595 0 None None None Human 6.2 pIC50 = 6.2 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 690 14 2 13 3.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
44320212 216653 0 None None None Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 520 9 2 7 4.7 O=C(O)COc1ccccc1Cn1nc(-c2ccccc2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O 10.1016/s0960-894x(00)00513-8
CHEMBL315280 216653 0 None None None Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 520 9 2 7 4.7 O=C(O)COc1ccccc1Cn1nc(-c2ccccc2)c(Cc2cc3c(cc2Cl)OCO3)c1C(=O)O 10.1016/s0960-894x(00)00513-8
44386161 124036 0 None None None Human 7.2 pIC50 = 7.2 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 573 9 1 9 5.6 CCC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL176650 124036 0 None None None Human 7.2 pIC50 = 7.2 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 573 9 1 9 5.6 CCC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
18996000 199560 0 None None None Human 6.2 pIC50 = 6.2 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 491 9 1 7 6.1 CCCOc1ccc2c(Sc3cccc(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2c1 10.1016/0960-894X(96)00232-6
CHEMBL282398 199560 0 None None None Human 6.2 pIC50 = 6.2 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 491 9 1 7 6.1 CCCOc1ccc2c(Sc3cccc(OC)c3)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2c1 10.1016/0960-894X(96)00232-6
10476492 333799 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 407 6 2 5 4.9 Cc1noc(NS(=O)(=O)c2cccc3c(NCc4ccccc4)cccc23)c1C 10.1021/jm00008a013
CHEMBL440653 333799 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 407 6 2 5 4.9 Cc1noc(NS(=O)(=O)c2cccc3c(NCc4ccccc4)cccc23)c1C 10.1021/jm00008a013
CHEMBL343379 487091 0 None None None Human 6.2 pIC50 = 6.2 Binding
Inhibitory effect against Human Endothelin A receptorInhibitory effect against Human Endothelin A receptor
ChEMBL 612 9 7 6 1.1 CC[C@H](C)[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC1=O 10.1021/jm00021a021
15453209 469993 0 None None None Human 5.2 pIC50 = 5.2 Binding
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 358 3 1 4 3.5 Cc1cc(C)c(S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/0960-894X(96)00441-6
CHEMBL77962 469993 0 None None None Human 5.2 pIC50 = 5.2 Binding
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 358 3 1 4 3.5 Cc1cc(C)c(S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/0960-894X(96)00441-6
19347988 199123 0 None None None Human 5.2 pIC50 = 5.2 Binding
Compound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptorCompound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptor
ChEMBL 316 4 1 4 4.8 COc1cccc(Sc2c(C(=O)O)sc3ccccc23)c1 10.1016/0960-894X(96)00232-6
CHEMBL27911 199123 0 None None None Human 5.2 pIC50 = 5.2 Binding
Compound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptorCompound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptor
ChEMBL 316 4 1 4 4.8 COc1cccc(Sc2c(C(=O)O)sc3ccccc23)c1 10.1016/0960-894X(96)00232-6
10289348 23618 0 None None None Rat 8.2 pIC50 = 8.2 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 516 16 1 5 5.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(CCC)CCC 10.1021/jm980217s
CHEMBL111023 23618 0 None None None Rat 8.2 pIC50 = 8.2 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 516 16 1 5 5.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(CCC)CCC 10.1021/jm980217s
44215416 349104 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 649 11 2 13 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccnc(-c3noc(=S)[nH]3)c2)nc1OCC1CCCO1 10.1016/j.bmcl.2016.06.014
CHEMBL4568468 349104 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 649 11 2 13 5.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(-c2ccnc(-c3noc(=S)[nH]3)c2)nc1OCC1CCCO1 10.1016/j.bmcl.2016.06.014
44212539 469039 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 671 12 2 12 5.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/j.bmcl.2016.06.014
CHEMBL70203 469039 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 671 12 2 12 5.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/j.bmcl.2016.06.014
10739431 122357 0 None None None Rat 8.2 pIC50 = 8.2 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 394 7 1 5 4.4 N#Cc1ccc(OCc2ccncc2)cc1OC(C(=O)O)c1ccccc1Cl 10.1021/jm990378b
CHEMBL171844 122357 0 None None None Rat 8.2 pIC50 = 8.2 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 394 7 1 5 4.4 N#Cc1ccc(OCc2ccncc2)cc1OC(C(=O)O)c1ccccc1Cl 10.1021/jm990378b
10740501 123051 0 None None None Rat 8.2 pIC50 = 8.2 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 414 7 1 6 4.8 Cc1ccccc1C(Oc1cc(OCc2ccc3ncoc3c2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL174235 123051 0 None None None Rat 8.2 pIC50 = 8.2 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 414 7 1 6 4.8 Cc1ccccc1C(Oc1cc(OCc2ccc3ncoc3c2)ccc1C#N)C(=O)O 10.1021/jm990378b
11799541 355122 0 None None None Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 499 8 3 9 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CCCO)OCO3)c1Cl 10.1021/jm9608366
CHEMBL47620 355122 0 None None None Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 499 8 3 9 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CCCO)OCO3)c1Cl 10.1021/jm9608366
44212539 469039 0 None None None Human 8.2 pIC50 = 8.2 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 671 12 2 12 5.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70203 469039 0 None None None Human 8.2 pIC50 = 8.2 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 671 12 2 12 5.9 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44311135 469118 0 None None None Human 8.2 pIC50 = 8.2 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 607 11 2 10 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70800 469118 0 None None None Human 8.2 pIC50 = 8.2 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 607 11 2 10 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44293720 346808 0 None None None Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 551 11 2 9 3.9 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)c(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL47868 346808 0 None None None Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 551 11 2 9 3.9 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)c(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
10554539 201374 0 None None None Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 543 9 2 11 3.4 CC(=O)OCCOc1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm9608366
CHEMBL296129 201374 0 None None None Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 543 9 2 11 3.4 CC(=O)OCCOc1cc2c(cc1NC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm9608366
137647152 313544 0 None None None Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 581 10 2 9 4.8 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC(C)C)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4081426 313544 0 None None None Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 581 10 2 9 4.8 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC(C)C)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
10429404 214583 0 None None None Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 372 5 1 4 3.7 CCc1ccc(CC)c(S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/0960-894X(96)00441-6
CHEMBL311138 214583 0 None None None Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 372 5 1 4 3.7 CCc1ccc(CC)c(S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/0960-894X(96)00441-6
44320315 216706 0 None None None Rat 8.2 pIC50 = 8.2 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 496 7 2 7 5.0 O=C(O)c1cccc(Cn2nc(-c3cccs3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c1 10.1016/s0960-894x(00)00513-8
CHEMBL315638 216706 0 None None None Rat 8.2 pIC50 = 8.2 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 496 7 2 7 5.0 O=C(O)c1cccc(Cn2nc(-c3cccs3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c1 10.1016/s0960-894x(00)00513-8
11006147 26696 0 None None None Pig 8.2 pIC50 = 8.2 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 550 11 2 10 4.7 COc1cccc(Oc2c(NCCOc3ncccn3)ncnc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1 10.1021/jm0102304
CHEMBL1185931 26696 0 None None None Pig 8.2 pIC50 = 8.2 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 550 11 2 10 4.7 COc1cccc(Oc2c(NCCOc3ncccn3)ncnc2NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1 10.1021/jm0102304
2809510 257236 2 None None None Human 8.2 pIC50 = 8.2 Binding
Inhibition of [125]ET-1 binding to human Endothelin A receptor expressed in vero cellsInhibition of [125]ET-1 binding to human Endothelin A receptor expressed in vero cells
ChEMBL 362 5 1 7 2.8 COC(=O)c1cc(S(=O)(=O)Nc2cccc(-c3cnco3)c2)oc1C 10.1021/jm031041j
CHEMBL367093 257236 2 None None None Human 8.2 pIC50 = 8.2 Binding
Inhibition of [125]ET-1 binding to human Endothelin A receptor expressed in vero cellsInhibition of [125]ET-1 binding to human Endothelin A receptor expressed in vero cells
ChEMBL 362 5 1 7 2.8 COC(=O)c1cc(S(=O)(=O)Nc2cccc(-c3cnco3)c2)oc1C 10.1021/jm031041j
10531650 332969 0 None None None Rat 8.2 pIC50 = 8.2 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 600 11 1 7 5.0 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccc(Cl)cc1 10.1021/jm970101g
CHEMBL433842 332969 0 None None None Rat 8.2 pIC50 = 8.2 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 600 11 1 7 5.0 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccc(Cl)cc1 10.1021/jm970101g
10918533 202899 0 None None None Rat 8.2 pIC50 = 8.2 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 536 8 1 6 6.8 CC(C)Oc1ccc2c(c1)C(c1ccc(OCc3ccccc3)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL305577 202899 0 None None None Rat 8.2 pIC50 = 8.2 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 536 8 1 6 6.8 CC(C)Oc1ccc2c(c1)C(c1ccc(OCc3ccccc3)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
52949155 42271 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 557 10 2 7 5.4 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC(C)C)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1271640 42271 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 557 10 2 7 5.4 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC(C)C)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
44315008 202887 0 None None None Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL 665 13 5 5 4.7 CCSCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL305524 202887 0 None None None Human 8.2 pIC50 = 8.2 Binding
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL 665 13 5 5 4.7 CCSCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
44458604 198871 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 559 6 2 7 3.7 Cn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(F)(F)F)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1016/s0960-894x(01)00660-6
CHEMBL276982 198871 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 559 6 2 7 3.7 Cn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(F)(F)F)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1016/s0960-894x(01)00660-6
10239569 38689 0 None None None Rat 8.2 pIC50 = 8.2 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 534 9 1 10 4.4 COc1cc(C/C(C(=O)c2ccc3c(c2)OCO3)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
CHEMBL1206715 38689 0 None None None Rat 8.2 pIC50 = 8.2 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 534 9 1 10 4.4 COc1cc(C/C(C(=O)c2ccc3c(c2)OCO3)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
52943105 42339 0 None None None Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 529 9 2 7 4.7 CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL1272190 42339 0 None None None Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 529 9 2 7 4.7 CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
52943105 42339 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 529 9 2 7 4.7 CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1272190 42339 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 529 9 2 7 4.7 CCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2010.08.074
10137382 356012 0 None None None Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 427 5 3 7 3.8 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(O)c1 10.1021/jm9608366
CHEMBL47827 356012 0 None None None Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 427 5 3 7 3.8 Cc1ccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(O)c1 10.1021/jm9608366
10527706 197325 0 None None None Rat 8.2 pIC50 = 8.2 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 454 8 1 6 3.1 CCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL266594 197325 0 None None None Rat 8.2 pIC50 = 8.2 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 454 8 1 6 3.1 CCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10671037 259327 0 None None None Rat 8.2 pIC50 = 8.2 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 8 1 6 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm031041j
CHEMBL369085 259327 0 None None None Rat 8.2 pIC50 = 8.2 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 446 8 1 6 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2cc(OC)c3c(c2)OCO3)cc1 10.1021/jm031041j
10503525 20198 0 None None None Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 446 6 1 7 3.8 COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL10794 20198 0 None None None Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 446 6 1 7 3.8 COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
44314609 469633 0 None None None Pig 8.2 pIC50 = 8.2 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 720 12 6 4 5.6 CC(C)CC(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)N[C@H](Cc1c(Br)[nH]c2ccccc12)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm9600914
CHEMBL74471 469633 0 None None None Pig 8.2 pIC50 = 8.2 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 720 12 6 4 5.6 CC(C)CC(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)N[C@H](Cc1c(Br)[nH]c2ccccc12)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm9600914
71460535 163114 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 693 15 1 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)CCCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163711 163114 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 693 15 1 12 5.1 COc1ccccc1Oc1c(NS(=O)(=O)CCCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
11826259 467971 0 None None None Rat 8.2 pIC50 = 8.2 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 437 8 1 7 4.5 CC(C)Oc1ccc2c(c1)C(OCCCC#N)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL62759 467971 0 None None None Rat 8.2 pIC50 = 8.2 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 437 8 1 7 4.5 CC(C)Oc1ccc2c(c1)C(OCCCC#N)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
71455139 163430 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 556 11 2 8 3.6 O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccccc1 10.1021/jm3009103
CHEMBL2165331 163430 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 556 11 2 8 3.6 O=S(=O)(NCc1ccccc1)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccccc1 10.1021/jm3009103
10697883 25519 0 None None None Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 548 8 3 10 2.5 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CNS(C)(=O)=O)OCO3)c1Cl 10.1021/jm9608366
CHEMBL1178885 25519 0 None None None Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 548 8 3 10 2.5 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CNS(C)(=O)=O)OCO3)c1Cl 10.1021/jm9608366
21979601 163427 0 None None None Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 602 13 2 10 3.7 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)ncnc1OCCOc1ncc(Br)cn1 10.1016/j.bmcl.2016.06.014
CHEMBL2165328 163427 0 None None None Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 602 13 2 10 3.7 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)ncnc1OCCOc1ncc(Br)cn1 10.1016/j.bmcl.2016.06.014
71462248 163132 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 676 17 2 12 3.8 COCCOc1nc(NS(=O)(=O)NCc2ccccc2)c(Oc2ccccc2OC)c(OCCOc2ncc(Br)cn2)n1 10.1021/jm3009103
CHEMBL2163728 163132 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 676 17 2 12 3.8 COCCOc1nc(NS(=O)(=O)NCc2ccccc2)c(Oc2ccccc2OC)c(OCCOc2ncc(Br)cn2)n1 10.1021/jm3009103
21979601 163427 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 602 13 2 10 3.7 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)ncnc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2165328 163427 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 602 13 2 10 3.7 COc1ccccc1Oc1c(NS(=O)(=O)NCc2ccccc2)ncnc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
10360201 196048 0 None None None Rat 7.2 pIC50 = 7.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1onc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00008a013
CHEMBL25816 196048 0 None None None Rat 7.2 pIC50 = 7.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1onc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00008a013
9974857 197700 0 None None None Rat 7.2 pIC50 = 7.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 5 2 5 3.7 CCNc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
CHEMBL26978 197700 0 None None None Rat 7.2 pIC50 = 7.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 5 2 5 3.7 CCNc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
CHEMBL1788127 486533 3 None None None Human 7.2 pIC50 = 7.2 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 923 25 9 8 4.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL313760 486533 3 None None None Human 7.2 pIC50 = 7.2 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 923 25 9 8 4.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
10506868 125968 0 None None None Rat 7.2 pIC50 = 7.2 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 550 10 5 5 4.7 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL179138 125968 0 None None None Rat 7.2 pIC50 = 7.2 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 550 10 5 5 4.7 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
44266594 18550 0 None None None Human 7.2 pIC50 = 7.2 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 491 8 1 8 4.8 COc1ccc(-c2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OC)cc23)cc1OC 10.1016/0960-894X(96)00170-9
CHEMBL10019 18550 0 None None None Human 7.2 pIC50 = 7.2 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 491 8 1 8 4.8 COc1ccc(-c2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OC)cc23)cc1OC 10.1016/0960-894X(96)00170-9
44266646 198827 0 None None None Human 7.2 pIC50 = 7.2 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 475 6 1 8 4.5 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00170-9
CHEMBL276638 198827 0 None None None Human 7.2 pIC50 = 7.2 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 475 6 1 8 4.5 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00170-9
2529 347569 76 None None None Human 6.2 pIC50 = 6.2 Binding
Antagonist activity at Endothelin receptor A (unknown origin)Antagonist activity at Endothelin receptor A (unknown origin)
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/j.ejmech.2025.117278
5344 347569 76 None None None Human 6.2 pIC50 = 6.2 Binding
Antagonist activity at Endothelin receptor A (unknown origin)Antagonist activity at Endothelin receptor A (unknown origin)
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/j.ejmech.2025.117278
CHEMBL453 347569 76 None None None Human 6.2 pIC50 = 6.2 Binding
Antagonist activity at Endothelin receptor A (unknown origin)Antagonist activity at Endothelin receptor A (unknown origin)
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/j.ejmech.2025.117278
DB00263 347569 76 None None None Human 6.2 pIC50 = 6.2 Binding
Antagonist activity at Endothelin receptor A (unknown origin)Antagonist activity at Endothelin receptor A (unknown origin)
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/j.ejmech.2025.117278
10577879 23574 0 None None None Human 6.2 pIC50 = 6.2 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 520 9 0 9 4.5 COc1ccc(C2(OC)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
CHEMBL11082 23574 0 None None None Human 6.2 pIC50 = 6.2 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 520 9 0 9 4.5 COc1ccc(C2(OC)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9606507
345351 23663 3 None None None Human 6.2 pIC50 = 6.2 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 386 4 1 5 3.8 O=C1OC(O)(c2ccccc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
CHEMBL11131 23663 3 None None None Human 6.2 pIC50 = 6.2 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 386 4 1 5 3.8 O=C1OC(O)(c2ccccc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
10763444 221140 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 399 7 1 5 5.0 O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1[N+](=O)[O-])c1ccccc1F 10.1021/jm970847e
CHEMBL328580 221140 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 399 7 1 5 5.0 O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1[N+](=O)[O-])c1ccccc1F 10.1021/jm970847e
10597928 222239 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 414 6 1 3 5.9 Cc1ccccc1/C(=C\c1cc(OCc2ccsc2)ccc1Br)CO 10.1021/jm970847e
CHEMBL330543 222239 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 414 6 1 3 5.9 Cc1ccccc1/C(=C\c1cc(OCc2ccsc2)ccc1Br)CO 10.1021/jm970847e
10690863 473801 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 375 7 1 4 4.8 O=C(O)/C(=C/c1cc(OCc2ccccc2)ccc1[N+](=O)[O-])c1ccccc1 10.1021/jm970847e
CHEMBL90666 473801 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 375 7 1 4 4.8 O=C(O)/C(=C/c1cc(OCc2ccccc2)ccc1[N+](=O)[O-])c1ccccc1 10.1021/jm970847e
44277263 216496 0 None None None Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 440 5 1 5 4.2 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3cc4c(cc3Cl)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144605 216496 0 None None None Rat 6.2 pIC50 = 6.2 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 440 5 1 5 4.2 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3cc4c(cc3Cl)OCO4)c2=O)c1 10.1016/s0960-894x(00)00232-8
10403526 201992 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3cc(N)ccc3c2)c1C 10.1021/jm00004a012
CHEMBL30075 201992 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3cc(N)ccc3c2)c1C 10.1021/jm00004a012
44270522 99082 0 None None None Human 6.2 pIC50 = 6.2 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 744 15 1 10 8.2 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1ccc(CC(C)C)s1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL15310 99082 0 None None None Human 6.2 pIC50 = 6.2 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 744 15 1 10 8.2 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1ccc(CC(C)C)s1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
44368390 98588 0 None None None Pig 5.2 pIC50 = 5.2 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 475 9 2 6 3.9 COc1ccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2ccc(O)cc2)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
CHEMBL152654 98588 0 None None None Pig 5.2 pIC50 = 5.2 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 475 9 2 6 3.9 COc1ccc(CN(C(=O)/C=C/c2ccc3c(c2)OCO3)C(Cc2ccc(O)cc2)C(=O)O)cc1 10.1016/s0960-894x(01)00009-9
14673588 18755 0 None None None Human 5.2 pIC50 = 5.2 Binding
Compound was evaluated for binding affinity against rabbit Endothelin A receptorCompound was evaluated for binding affinity against rabbit Endothelin A receptor
ChEMBL 342 6 1 4 5.0 CC(C)Oc1c(C(=O)O)sc2ccc(OCc3ccccc3)cc12 10.1016/0960-894X(96)00170-9
CHEMBL10143 18755 0 None None None Human 5.2 pIC50 = 5.2 Binding
Compound was evaluated for binding affinity against rabbit Endothelin A receptorCompound was evaluated for binding affinity against rabbit Endothelin A receptor
ChEMBL 342 6 1 4 5.0 CC(C)Oc1c(C(=O)O)sc2ccc(OCc3ccccc3)cc12 10.1016/0960-894X(96)00170-9
14673588 18755 0 None None None Human 5.2 pIC50 = 5.2 Binding
Compound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptorCompound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptor
ChEMBL 342 6 1 4 5.0 CC(C)Oc1c(C(=O)O)sc2ccc(OCc3ccccc3)cc12 10.1016/0960-894X(96)00232-6
CHEMBL10143 18755 0 None None None Human 5.2 pIC50 = 5.2 Binding
Compound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptorCompound was evaluated for the receptor binding activity in rabbit artery vascular smooth muscle cells expressing Endothelin A receptor
ChEMBL 342 6 1 4 5.0 CC(C)Oc1c(C(=O)O)sc2ccc(OCc3ccccc3)cc12 10.1016/0960-894X(96)00232-6
10735178 474111 0 None None None Rat 5.2 pIC50 = 5.2 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 330 6 1 2 4.9 O=C(O)/C(=C/c1cccc(OCc2ccccc2)c1)c1ccccc1 10.1021/jm970847e
CHEMBL92607 474111 0 None None None Rat 5.2 pIC50 = 5.2 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 330 6 1 2 4.9 O=C(O)/C(=C/c1cccc(OCc2ccccc2)c1)c1ccccc1 10.1021/jm970847e
22998396 200958 0 None None None Human 6.2 pIC50 = 6.2 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 398 4 1 5 4.3 Cc1noc(NS(=O)(=O)c2ccsc2-c2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL293232 200958 0 None None None Human 6.2 pIC50 = 6.2 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 398 4 1 5 4.3 Cc1noc(NS(=O)(=O)c2ccsc2-c2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
22998396 200958 0 None None None Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 398 4 1 5 4.3 Cc1noc(NS(=O)(=O)c2ccsc2-c2ccccc2)c1Br 10.1016/S0960-894X(97)00367-3
CHEMBL293232 200958 0 None None None Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 398 4 1 5 4.3 Cc1noc(NS(=O)(=O)c2ccsc2-c2ccccc2)c1Br 10.1016/S0960-894X(97)00367-3
10685758 468156 1 None None None Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 302 4 2 6 1.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)O)c1C 10.1016/S0960-894X(97)00367-3
CHEMBL64006 468156 1 None None None Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 302 4 2 6 1.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)O)c1C 10.1016/S0960-894X(97)00367-3
192311 216907 1 None None None Pig 7.2 pIC50 = 7.2 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 513 11 5 4 2.8 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31702 216907 1 None None None Pig 7.2 pIC50 = 7.2 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 513 11 5 4 2.8 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
10627805 40464 0 None None None Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 630 7 2 6 5.4 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(Br)cccc2Br)cc1 10.1021/jm990170q
CHEMBL123926 40464 0 None None None Human 7.2 pIC50 = 7.2 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 630 7 2 6 5.4 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(Br)cccc2Br)cc1 10.1021/jm990170q
22467231 198574 0 None None None Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 515 6 1 7 4.5 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C#N)ccc23)cc1 10.1016/s0960-894x(01)00660-6
CHEMBL274758 198574 0 None None None Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 515 6 1 7 4.5 CC(C)c1ccc(S(=O)(=O)NC(=O)C(c2ccc3c(c2)OCO3)c2cn(C)c3cc(C#N)ccc23)cc1 10.1016/s0960-894x(01)00660-6
52943235 41982 0 None None None Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 571 12 2 7 5.9 CCCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1269101 41982 0 None None None Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 571 12 2 7 5.9 CCCCCOc1ccc2c(c1)c(=O)c(Cc1cccc(C(=O)O)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2010.08.074
44332803 19047 0 None None None Human 4.2 pIC50 = 4.2 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 335 3 0 5 3.6 COC(=O)C(c1ccc2c(c1)OCO2)c1cc(C)nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL103497 19047 0 None None None Human 4.2 pIC50 = 4.2 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 335 3 0 5 3.6 COC(=O)C(c1ccc2c(c1)OCO2)c1cc(C)nc2ccccc12 10.1016/S0960-894X(96)00551-3
22998414 468068 0 None None None Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 422 5 1 9 3.1 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1C 10.1016/S0960-894X(97)00367-3
CHEMBL63290 468068 0 None None None Human 5.2 pIC50 = 5.2 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 422 5 1 9 3.1 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1C 10.1016/S0960-894X(97)00367-3
9984393 122848 0 None None None Human 7.2 pIC50 = 7.2 Binding
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 527 11 4 5 2.8 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00144-I
CHEMBL173808 122848 0 None None None Human 7.2 pIC50 = 7.2 Binding
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 527 11 4 5 2.8 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00144-I
18617345 214902 0 None None None Human 7.2 pIC50 = 7.2 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 384 3 1 4 3.9 Cc1noc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL311461 214902 0 None None None Human 7.2 pIC50 = 7.2 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 384 3 1 4 3.9 Cc1noc(NS(=O)(=O)c2cc(Cl)cc(Cl)c2)c1Br 10.1016/0960-894X(96)00441-6
10918216 467917 0 None None None Rat 7.2 pIC50 = 7.2 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 508 7 1 6 6.0 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OCc4ccccc4)cc32)cc1 10.1021/jm010382z
CHEMBL62450 467917 0 None None None Rat 7.2 pIC50 = 7.2 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 508 7 1 6 6.0 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OCc4ccccc4)cc32)cc1 10.1021/jm010382z
10576889 25516 0 None None None Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 485 6 3 7 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cccc(C(=O)O)c2)c1Br 10.1021/jm9608366
CHEMBL1178864 25516 0 None None None Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 485 6 3 7 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cccc(C(=O)O)c2)c1Br 10.1021/jm9608366
23445457 256958 0 None None None Human 7.2 pIC50 = 7.2 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 470 6 1 6 5.1 Cc1cc(C)c(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00132-7
CHEMBL367024 256958 0 None None None Human 7.2 pIC50 = 7.2 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 470 6 1 6 5.1 Cc1cc(C)c(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00132-7
23445304 259235 0 None None None Human 7.2 pIC50 = 7.2 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 484 6 1 7 4.4 Cc1cc2c(cc1CCc1sccc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00133-9
CHEMBL368780 259235 0 None None None Human 7.2 pIC50 = 7.2 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 484 6 1 7 4.4 Cc1cc2c(cc1CCc1sccc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00133-9
CHEMBL407771 487983 0 None None None Pig 7.2 pIC50 = 7.2 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 610 8 6 6 1.0 CCCC[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
18995989 200708 0 None None None Human 6.2 pIC50 = 6.2 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 583 9 1 9 6.6 COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OCc1ccccc1 10.1016/0960-894X(96)00232-6
CHEMBL29147 200708 0 None None None Human 6.2 pIC50 = 6.2 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 583 9 1 9 6.6 COc1cc2c(Sc3ccc4c(c3)OCO4)c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c2cc1OCc1ccccc1 10.1016/0960-894X(96)00232-6
10711546 470317 5 None None None Human 6.2 pIC50 = 6.2 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1noc(NS(=O)(=O)c2ccccc2Br)c1C 10.1016/0960-894X(96)00441-6
CHEMBL80506 470317 5 None None None Human 6.2 pIC50 = 6.2 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1noc(NS(=O)(=O)c2ccccc2Br)c1C 10.1016/0960-894X(96)00441-6
44279360 216255 0 None None None Pig 6.2 pIC50 = 6.2 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 498 13 5 4 2.9 CC(C)C[C@H](NC(=O)CC1CCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31426 216255 0 None None None Pig 6.2 pIC50 = 6.2 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 498 13 5 4 2.9 CC(C)C[C@H](NC(=O)CC1CCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
10602475 123138 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 537 9 3 6 4.6 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL174658 123138 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 537 9 3 6 4.6 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950592+
44327585 317308 0 None None None Human 5.2 pIC50 = 5.2 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 992 26 9 8 5.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C1CCCCC1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL414082 317308 0 None None None Human 5.2 pIC50 = 5.2 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 992 26 9 8 5.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)C1CCCCC1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL2304017 485319 0 None None None Human 5.2 pIC50 = 5.2 Binding
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL 667 7 6 8 0.8 CSC(C)(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(C#N)[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC1=O 10.1021/jm9600914
44298324 392027 0 None None None Rat 5.2 pIC50 = 5.2 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 448 7 2 7 4.4 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CO)c1 10.1016/s0960-894x(00)00366-8
CHEMBL55876 392027 0 None None None Rat 5.2 pIC50 = 5.2 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 448 7 2 7 4.4 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CO)c1 10.1016/s0960-894x(00)00366-8
23445457 256958 0 None None None Human 4.2 pIC50 = 4.2 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 470 6 1 6 5.1 Cc1cc(C)c(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL367024 256958 0 None None None Human 4.2 pIC50 = 4.2 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 470 6 1 6 5.1 Cc1cc(C)c(OCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c(C)c1 10.1016/S0960-894X(97)00133-9
44383537 122030 0 None None None Human 4.2 pIC50 = 4.2 Binding
Tested for binding affinity towards human Endothelin A receptorTested for binding affinity towards human Endothelin A receptor
ChEMBL 388 4 2 5 3.4 C/C=C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(O)[C@]2(O)[C@@]2(C)CCCC(C)(C)C12 10.1016/s0960-894x(00)00136-0
CHEMBL170335 122030 0 None None None Human 4.2 pIC50 = 4.2 Binding
Tested for binding affinity towards human Endothelin A receptorTested for binding affinity towards human Endothelin A receptor
ChEMBL 388 4 2 5 3.4 C/C=C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(O)[C@]2(O)[C@@]2(C)CCCC(C)(C)C12 10.1016/s0960-894x(00)00136-0
127036867 274785 0 None None None Human 6.2 pIC50 = 6.2 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 614 11 3 8 5.7 CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3753134 274785 0 None None None Human 6.2 pIC50 = 6.2 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 614 11 3 8 5.7 CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
9896468 335217 0 None None None Rat 7.2 pIC50 = 7.2 Binding
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 703 13 2 10 6.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCCC(=O)Nc1ccccc1C(C)C 10.1016/j.bmcl.2016.06.014
CHEMBL4451582 335217 0 None None None Rat 7.2 pIC50 = 7.2 Binding
Displacement of 125I-ET1 from ETA receptor in rat A7R5 cellsDisplacement of 125I-ET1 from ETA receptor in rat A7R5 cells
ChEMBL 703 13 2 10 6.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(N2CCOCC2)nc1OCCC(=O)Nc1ccccc1C(C)C 10.1016/j.bmcl.2016.06.014
10646616 468754 1 None None None Human 7.2 pIC50 = 7.2 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 436 5 1 6 3.3 COc1nc(Br)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
CHEMBL6800 468754 1 None None None Human 7.2 pIC50 = 7.2 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 436 5 1 6 3.3 COc1nc(Br)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
10555208 26674 0 None None None Human 7.2 pIC50 = 7.2 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 578 9 2 6 5.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2ccccc2C)cc1 10.1021/jm990171i
CHEMBL1185774 26674 0 None None None Human 7.2 pIC50 = 7.2 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 578 9 2 6 5.5 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)c2ccccc2C)cc1 10.1021/jm990171i
10740507 256978 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 414 7 1 4 4.9 CCc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
CHEMBL367032 256978 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 414 7 1 4 4.9 CCc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1021/jm031041j
10693110 198580 0 None None None Human 6.2 pIC50 = 6.2 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 414 5 1 5 4.4 CCc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL274805 198580 0 None None None Human 6.2 pIC50 = 6.2 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 414 5 1 5 4.4 CCc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
11733215 468179 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 459 6 1 6 4.6 COc1ccc(C2=C(C(N)=O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL64127 468179 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 459 6 1 6 4.6 COc1ccc(C2=C(C(N)=O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
44298409 389541 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 490 10 2 7 5.2 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCCO)c1 10.1016/s0960-894x(00)00366-8
CHEMBL54770 389541 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 490 10 2 7 5.2 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCCO)c1 10.1016/s0960-894x(00)00366-8
44383771 122626 0 None None None Rat 6.2 pIC50 = 6.2 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 371 7 1 6 4.5 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccsc1 10.1021/jm990378b
CHEMBL172879 122626 0 None None None Rat 6.2 pIC50 = 6.2 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 371 7 1 6 4.5 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccsc1 10.1021/jm990378b
10717923 198946 0 None None None Human 6.2 pIC50 = 6.2 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 439 5 2 6 4.7 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1016/S0960-894X(97)00133-9
CHEMBL277595 198946 0 None None None Human 6.2 pIC50 = 6.2 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 439 5 2 6 4.7 Cc1cc(C)c(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1016/S0960-894X(97)00133-9
10550094 468128 0 None None None Human 6.2 pIC50 = 6.2 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 420 4 1 5 3.6 Cc1nc(Br)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
CHEMBL6382 468128 0 None None None Human 6.2 pIC50 = 6.2 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 420 4 1 5 3.6 Cc1nc(Br)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
10740138 469036 0 None None None Human 6.2 pIC50 = 6.2 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 406 4 1 5 3.3 CN(C)c1cccc2c(S(=O)(=O)Nc3cnc(Br)nc3)cccc12 10.1021/jm9604585
CHEMBL7019 469036 0 None None None Human 6.2 pIC50 = 6.2 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 406 4 1 5 3.3 CN(C)c1cccc2c(S(=O)(=O)Nc3cnc(Br)nc3)cccc12 10.1021/jm9604585
44327890 278637 0 None None None Human 5.2 pIC50 = 5.2 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 985 26 9 8 5.5 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
CHEMBL384052 278637 0 None None None Human 5.2 pIC50 = 5.2 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 985 26 9 8 5.5 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
44298304 201676 0 None None None Rat 5.2 pIC50 = 5.2 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 503 10 2 7 4.7 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC(N)=O)c1 10.1016/s0960-894x(00)00366-8
CHEMBL298395 201676 0 None None None Rat 5.2 pIC50 = 5.2 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 503 10 2 7 4.7 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCCC(N)=O)c1 10.1016/s0960-894x(00)00366-8
10496523 468312 0 None None None Human 5.2 pIC50 = 5.2 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 328 4 1 5 2.5 CN(C)c1cccc2c(S(=O)(=O)Nc3ncccn3)cccc12 10.1021/jm9604585
CHEMBL6468 468312 0 None None None Human 5.2 pIC50 = 5.2 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 328 4 1 5 2.5 CN(C)c1cccc2c(S(=O)(=O)Nc3ncccn3)cccc12 10.1021/jm9604585
17869231 38532 0 None None None Rat 7.2 pIC50 = 7.2 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 548 11 1 9 5.5 COc1cc(C/C(C(=O)c2ccc(OC(C)C)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
CHEMBL1205061 38532 0 None None None Rat 7.2 pIC50 = 7.2 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 548 11 1 9 5.5 COc1cc(C/C(C(=O)c2ccc(OC(C)C)cc2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
9853077 122403 0 None None None Human 7.2 pIC50 = 7.2 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 696 13 2 12 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL172030 122403 0 None None None Human 7.2 pIC50 = 7.2 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 696 13 2 12 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL1791008 484823 0 None None None Pig 7.2 pIC50 = 7.2 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 624 8 6 6 1.2 CC[C@@H](C)[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC1=O 10.1021/jm00021a021
44327238 217029 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 497 8 1 8 3.1 CCCc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
CHEMBL318017 217029 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Inhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranesInhibition of specific binding of [125I]ET1 (endothelin 1) to the endothelin A receptor of rat aorta membranes
ChEMBL 497 8 1 8 3.1 CCCc1ccc(=O)n(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)n1 10.1016/S0960-894X(96)00617-8
44277036 334775 0 None None None Rat 4.2 pIC50 = 4.2 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 492 10 1 7 4.5 COc1cccc(Cn2nc(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2OCCCC(=O)O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL444545 334775 0 None None None Rat 4.2 pIC50 = 4.2 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 492 10 1 7 4.5 COc1cccc(Cn2nc(C(F)(F)F)c(Cc3ccc4c(c3)OCO4)c2OCCCC(=O)O)c1 10.1016/s0960-894x(00)00232-8
44294712 38693 0 None None None Rat 7.2 pIC50 = 7.2 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 566 11 1 9 5.6 COc1cc(C/C(C(=O)c2ccc(OC(C)C)c(F)c2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
CHEMBL1206722 38693 0 None None None Rat 7.2 pIC50 = 7.2 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 566 11 1 9 5.6 COc1cc(C/C(C(=O)c2ccc(OC(C)C)c(F)c2)=C(/C(=O)O)c2ccc3nsnc3c2)cc(OC)c1OC 10.1016/s0960-894x(98)00301-1
11071689 23765 0 None None None Pig 7.2 pIC50 = 7.2 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 549 11 1 8 5.8 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ccccc2)c1 10.1021/jm0102304
CHEMBL111876 23765 0 None None None Pig 7.2 pIC50 = 7.2 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 549 11 1 8 5.8 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ccccc2)c1 10.1021/jm0102304
23445468 25512 0 None None None Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 459 5 3 9 2.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(O)nn2)c1Br 10.1021/jm9608366
CHEMBL1178818 25512 0 None None None Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 459 5 3 9 2.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(O)nn2)c1Br 10.1021/jm9608366
CHEMBL263295 486079 0 None None None Human 6.2 pIC50 = 6.2 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 964 25 9 8 5.1 CC[C@H](C)[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
44279677 202315 0 None None None Human 6.2 pIC50 = 6.2 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 478 2 2 3 4.0 O=C1c2cc(Br)ccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(Br)cc21 10.1016/0960-894X(95)00230-Q
CHEMBL30297 202315 0 None None None Human 6.2 pIC50 = 6.2 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 478 2 2 3 4.0 O=C1c2cc(Br)ccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(Br)cc21 10.1016/0960-894X(95)00230-Q
CHEMBL147908 484697 0 None None None Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cellsDisplacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cells
ChEMBL 863 25 10 9 1.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81215-4
23445412 202349 0 None None None Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 426 5 1 7 4.3 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1016/S0960-894X(97)00367-3
CHEMBL303203 202349 0 None None None Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 426 5 1 7 4.3 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c(C)c1 10.1016/S0960-894X(97)00367-3
44385942 124136 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2C)nc1C(=O)O 10.1021/jm950592+
CHEMBL176913 124136 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2C)nc1C(=O)O 10.1021/jm950592+
10449431 200213 0 None None None Human 5.2 pIC50 = 5.2 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 332 4 1 5 3.3 COc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00029a001
CHEMBL28692 200213 0 None None None Human 5.2 pIC50 = 5.2 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 332 4 1 5 3.3 COc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00029a001
44276828 197099 0 None None None Rat 5.2 pIC50 = 5.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 324 5 3 6 1.0 Cc1noc(NS(=O)(=O)c2ccc(NC(=O)CN)cc2)c1C 10.1021/jm00008a013
CHEMBL26470 197099 0 None None None Rat 5.2 pIC50 = 5.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 324 5 3 6 1.0 Cc1noc(NS(=O)(=O)c2ccc(NC(=O)CN)cc2)c1C 10.1021/jm00008a013
10449431 200213 0 None None None Rat 5.2 pIC50 = 5.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 332 4 1 5 3.3 COc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
CHEMBL28692 200213 0 None None None Rat 5.2 pIC50 = 5.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 332 4 1 5 3.3 COc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
CHEMBL436884 488638 0 None None None Rat 5.2 pIC50 = 5.2 Binding
In vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricleIn vitro binding affinity against Endothelin A receptor by using endothelin (ET-1) as radioligand in rat heart ventricle
ChEMBL 1409 30 16 17 1.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
44383537 122030 0 None None None Human 4.2 pIC50 = 4.2 Binding
Tested for binding affinity towards rabbit Endothelin A receptorTested for binding affinity towards rabbit Endothelin A receptor
ChEMBL 388 4 2 5 3.4 C/C=C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(O)[C@]2(O)[C@@]2(C)CCCC(C)(C)C12 10.1016/s0960-894x(00)00136-0
CHEMBL170335 122030 0 None None None Human 4.2 pIC50 = 4.2 Binding
Tested for binding affinity towards rabbit Endothelin A receptorTested for binding affinity towards rabbit Endothelin A receptor
ChEMBL 388 4 2 5 3.4 C/C=C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(O)[C@]2(O)[C@@]2(C)CCCC(C)(C)C12 10.1016/s0960-894x(00)00136-0
6450144 241134 4 None None None Rat 7.2 pIC50 = 7.2 Binding
Antagonist activity at endothelin A receptor in Wistar rat thoracic aorta strips assessed as inhibition of ET1-induced vasoconstriction preincubated for 5 mins followed by ET1 additionAntagonist activity at endothelin A receptor in Wistar rat thoracic aorta strips assessed as inhibition of ET1-induced vasoconstriction preincubated for 5 mins followed by ET1 addition
ChEMBL 632 5 3 6 8.1 CC1(C)CC[C@]2(C(=O)O)CC[C@]3(COC(=O)/C=C/c4ccc(O)c(O)c4)C(=CC[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1 10.1016/j.bmc.2015.06.055
CHEMBL3601500 241134 4 None None None Rat 7.2 pIC50 = 7.2 Binding
Antagonist activity at endothelin A receptor in Wistar rat thoracic aorta strips assessed as inhibition of ET1-induced vasoconstriction preincubated for 5 mins followed by ET1 additionAntagonist activity at endothelin A receptor in Wistar rat thoracic aorta strips assessed as inhibition of ET1-induced vasoconstriction preincubated for 5 mins followed by ET1 addition
ChEMBL 632 5 3 6 8.1 CC1(C)CC[C@]2(C(=O)O)CC[C@]3(COC(=O)/C=C/c4ccc(O)c(O)c4)C(=CC[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1 10.1016/j.bmc.2015.06.055
11728313 328267 0 None None None Rat 7.2 pIC50 = 7.2 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 368 6 1 5 4.2 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm010382z
CHEMBL418667 328267 0 None None None Rat 7.2 pIC50 = 7.2 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 368 6 1 5 4.2 CCCCOC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccccc21 10.1021/jm010382z
CHEMBL2304008 485310 0 None None None Pig 7.2 pIC50 = 7.2 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 720 7 6 7 1.7 CSC(C)(C)[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc2c(Br)[nH]c3ccccc23)NC(=O)[C@@H](C(C)C)NC1=O 10.1021/jm9600914
19363918 38542 0 None None None Rat 7.2 pIC50 = 7.2 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 474 7 1 8 4.4 COc1ccc(C(=O)/C(Cc2ccc3c(c2)OCO3)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1205106 38542 0 None None None Rat 7.2 pIC50 = 7.2 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 474 7 1 8 4.4 COc1ccc(C(=O)/C(Cc2ccc3c(c2)OCO3)=C(\C(=O)O)c2ccc3nsnc3c2)cc1 10.1016/s0960-894x(98)00301-1
44293927 202119 0 None None None Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 507 9 1 8 4.4 CCOc1ccc2c(c1)[C@@H](c1cc(OC)c(OC)c(OC)c1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL301723 202119 0 None None None Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 507 9 1 8 4.4 CCOc1ccc2c(c1)[C@@H](c1cc(OC)c(OC)c(OC)c1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
135884434 258471 0 None None None Human 7.2 pIC50 = 7.2 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 628 10 2 12 5.2 C#CCOc1nc(-c2ccnc(-c3noc(O)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL368117 258471 0 None None None Human 7.2 pIC50 = 7.2 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 628 10 2 12 5.2 C#CCOc1nc(-c2ccnc(-c3noc(O)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
44386535 259252 0 None None None Rat 7.2 pIC50 = 7.2 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 549 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2cccc(F)c2)nc1C(=O)O 10.1021/jm950592+
CHEMBL368853 259252 0 None None None Rat 7.2 pIC50 = 7.2 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 549 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2cccc(F)c2)nc1C(=O)O 10.1021/jm950592+
10403526 201992 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3cc(N)ccc3c2)c1C 10.1021/jm00008a013
CHEMBL30075 201992 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3cc(N)ccc3c2)c1C 10.1021/jm00008a013
10815902 331049 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 523 10 5 5 4.6 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL426589 331049 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 523 10 5 5 4.6 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm950592+
44332578 18664 0 None None None Human 4.2 pIC50 = 4.2 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 413 3 0 5 5.6 CC(C)(C)OC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL100874 18664 0 None None None Human 4.2 pIC50 = 4.2 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 413 3 0 5 5.6 CC(C)(C)OC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL431874 488579 0 None None None Human 5.2 pIC50 = 5.2 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 863 25 10 9 1.4 CC[C@H](C)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00070a001
44279251 200238 0 None None None Pig 5.2 pIC50 = 5.2 Binding
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 486 12 5 4 2.8 CC(C)C[C@H](NC(=O)CC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL287141 200238 0 None None None Pig 5.2 pIC50 = 5.2 Binding
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 486 12 5 4 2.8 CC(C)C[C@H](NC(=O)CC(C)(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
10265127 197162 1 None None None Human 5.2 pIC50 = 5.2 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 270 3 1 4 2.2 Cc1noc(NS(=O)(=O)c2ccc(F)cc2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL26522 197162 1 None None None Human 5.2 pIC50 = 5.2 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 270 3 1 4 2.2 Cc1noc(NS(=O)(=O)c2ccc(F)cc2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL3301647 486735 0 None None None Pig 5.2 pIC50 = 5.2 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 596 6 6 6 0.4 CC(C)C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
10880982 202825 0 None None None Rat 4.2 pIC50 = 4.2 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 296 2 1 4 3.0 O=C(O)C1=Cc2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm031041j
CHEMBL305149 202825 0 None None None Rat 4.2 pIC50 = 4.2 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 296 2 1 4 3.0 O=C(O)C1=Cc2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm031041j
10880982 202825 0 None None None Rat 4.2 pIC50 = 4.2 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 296 2 1 4 3.0 O=C(O)C1=Cc2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm010382z
CHEMBL305149 202825 0 None None None Rat 4.2 pIC50 = 4.2 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 296 2 1 4 3.0 O=C(O)C1=Cc2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm010382z
CHEMBL385492 487663 0 None None None Human 7.2 pIC50 = 7.2 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 973 25 10 9 4.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00015a003
10737416 122502 0 None None None Rat 7.2 pIC50 = 7.2 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 363 7 1 5 4.2 Cc1ccccc1C(Oc1cc(OCc2ccoc2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL172412 122502 0 None None None Rat 7.2 pIC50 = 7.2 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 363 7 1 5 4.2 Cc1ccccc1C(Oc1cc(OCc2ccoc2)ccc1C#N)C(=O)O 10.1021/jm990378b
44293526 201487 0 None None None Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 563 11 2 8 4.9 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCC(C)(C)C(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL296974 201487 0 None None None Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 563 11 2 8 4.9 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCC(C)(C)C(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
10336018 202201 0 None None None Rat 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 318 3 2 5 3.0 Cc1noc(NS(=O)(=O)c2cccc3c(O)cccc23)c1C 10.1021/jm00004a012
CHEMBL30228 202201 0 None None None Rat 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 318 3 2 5 3.0 Cc1noc(NS(=O)(=O)c2cccc3c(O)cccc23)c1C 10.1021/jm00004a012
22998438 468126 0 None None None Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 456 5 1 7 4.1 Cc1ccccc1OC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(97)00367-3
CHEMBL63805 468126 0 None None None Human 6.2 pIC50 = 6.2 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 456 5 1 7 4.1 Cc1ccccc1OC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(97)00367-3
10602451 124505 0 None None None Human 6.2 pIC50 = 6.2 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 536 11 3 6 5.1 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)CC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL177179 124505 0 None None None Human 6.2 pIC50 = 6.2 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 536 11 3 6 5.1 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)CC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
1011 6819 32 None None None Human 5.2 pIC50 = 5.2 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 609 12 3 10 4.8 OC[C@H](COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ccc(cc1)OC)O 10.1016/j.bmcl.2016.06.014
5312146 6819 32 None None None Human 5.2 pIC50 = 5.2 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 609 12 3 10 4.8 OC[C@H](COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ccc(cc1)OC)O 10.1016/j.bmcl.2016.06.014
CHEMBL1628620 6819 32 None None None Human 5.2 pIC50 = 5.2 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 609 12 3 10 4.8 OC[C@H](COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ccc(cc1)OC)O 10.1016/j.bmcl.2016.06.014
10531851 122530 0 None None None Rat 4.2 pIC50 = 4.2 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 614 11 3 7 5.3 CC(C)C[C@H](NC(=O)N1CCCCCC1)c1nc(C(=O)N[C@H](Cc2ccccn2)C(=O)O)c(Cc2cn(C)c3ccccc23)o1 10.1021/jm950591h
CHEMBL172506 122530 0 None None None Rat 4.2 pIC50 = 4.2 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 614 11 3 7 5.3 CC(C)C[C@H](NC(=O)N1CCCCCC1)c1nc(C(=O)N[C@H](Cc2ccccn2)C(=O)O)c(Cc2cn(C)c3ccccc23)o1 10.1021/jm950591h
10529715 474066 0 None None None Rat 5.2 pIC50 = 5.2 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)CC(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9228 474066 0 None None None Rat 5.2 pIC50 = 5.2 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)CC(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10694547 473999 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 443 10 1 7 2.9 COCCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL9183 473999 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 443 10 1 7 2.9 COCCOCCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10836835 197422 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 440 7 2 5 3.8 CCCCNC(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL267483 197422 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 440 7 2 5 3.8 CCCCNC(=O)N1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10599453 474176 0 None None None Rat 7.2 pIC50 = 7.2 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 445 9 1 6 5.2 Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N 10.1021/jm9707131
CHEMBL93097 474176 0 None None None Rat 7.2 pIC50 = 7.2 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 445 9 1 6 5.2 Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N 10.1021/jm9707131
2527 333383 75 None None None Rat 4.2 pIC50 = 4.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 10.1021/jm00008a013
5340 333383 75 None None None Rat 4.2 pIC50 = 4.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 10.1021/jm00008a013
CHEMBL437 333383 75 None None None Rat 4.2 pIC50 = 4.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 10.1021/jm00008a013
DB06147 333383 75 None None None Rat 4.2 pIC50 = 4.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 10.1021/jm00008a013
2527 333383 75 None None None Human 4.2 pIC50 = 4.2 Binding
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 10.1021/jm030480f
5340 333383 75 None None None Human 4.2 pIC50 = 4.2 Binding
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 10.1021/jm030480f
CHEMBL437 333383 75 None None None Human 4.2 pIC50 = 4.2 Binding
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 10.1021/jm030480f
DB06147 333383 75 None None None Human 4.2 pIC50 = 4.2 Binding
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 10.1021/jm030480f
18995991 200468 0 None None None Human 8.2 pIC50 = 8.2 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 537 8 1 10 5.0 COc1cc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc(OC)c1OC 10.1016/0960-894X(96)00232-6
CHEMBL28920 200468 0 None None None Human 8.2 pIC50 = 8.2 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 537 8 1 10 5.0 COc1cc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)cc(OC)c1OC 10.1016/0960-894X(96)00232-6
10649585 219331 0 None None None Rat 8.2 pIC50 = 8.2 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 518 14 1 7 3.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCC1OCCO1 10.1021/jm980217s
CHEMBL323175 219331 0 None None None Rat 8.2 pIC50 = 8.2 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 518 14 1 7 3.9 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CCCC1OCCO1 10.1021/jm980217s
22574723 39828 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 549 11 2 7 5.2 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CC)c1 10.1039/C4MD00499J
CHEMBL12233 39828 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 549 11 2 7 5.2 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CC)c1 10.1039/C4MD00499J
20747575 198694 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 579 12 2 8 5.0 CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COC)c1 10.1039/C4MD00499J
CHEMBL275545 198694 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 579 12 2 8 5.0 CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COC)c1 10.1039/C4MD00499J
71455064 163125 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 694 14 1 12 4.5 COc1ccccc1Oc1c(NS(=O)(=O)N(C)Cc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163721 163125 0 None None None Human 8.2 pIC50 = 8.2 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 694 14 1 12 4.5 COc1ccccc1Oc1c(NS(=O)(=O)N(C)Cc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
10693270 122845 1 None None None Rat 8.2 pIC50 = 8.2 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
9931773 122845 1 None None None Rat 8.2 pIC50 = 8.2 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL173792 122845 1 None None None Rat 8.2 pIC50 = 8.2 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL2110231 122845 1 None None None Rat 8.2 pIC50 = 8.2 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
10601191 222274 0 None None None Rat 8.2 pIC50 = 8.2 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 492 11 3 6 5.7 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1cc(C(=O)O)[nH]n1 10.1021/jm9707131
CHEMBL330679 222274 0 None None None Rat 8.2 pIC50 = 8.2 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 492 11 3 6 5.7 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1-c1cc(C(=O)O)[nH]n1 10.1021/jm9707131
22010244 473746 0 None None None Rat 8.2 pIC50 = 8.2 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 407 9 1 5 5.5 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C#N 10.1021/jm9707131
CHEMBL90320 473746 0 None None None Rat 8.2 pIC50 = 8.2 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 407 9 1 5 5.5 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C#N 10.1021/jm9707131
10740214 474207 0 None None None Rat 8.2 pIC50 = 8.2 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 408 9 1 6 4.9 Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2cnsc2)ccc1C#N 10.1021/jm9707131
CHEMBL93331 474207 0 None None None Rat 8.2 pIC50 = 8.2 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 408 9 1 6 4.9 Cc1ccccc1[C@@H](CCC(=O)O)Oc1cc(OCc2cnsc2)ccc1C#N 10.1021/jm9707131
10190108 258592 0 None None None Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 681 12 2 12 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
CHEMBL368386 258592 0 None None None Human 8.2 pIC50 = 8.2 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 681 12 2 12 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(-c2ccncc2)nc1OCC#CCOC(=O)Nc1ccccn1 10.1016/s0960-894x(02)01084-3
44333887 218218 0 None None None Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 446 7 2 6 3.9 CCNCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
CHEMBL320631 218218 0 None None None Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 446 7 2 6 3.9 CCNCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
44311528 469081 0 None None None Human 8.2 pIC50 = 8.2 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 633 12 2 10 6.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70487 469081 0 None None None Human 8.2 pIC50 = 8.2 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 633 12 2 10 6.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C2CC2)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
44311284 469169 0 None None None Human 8.2 pIC50 = 8.2 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 635 12 2 10 6.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)C)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL71070 469169 0 None None None Human 8.2 pIC50 = 8.2 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 635 12 2 10 6.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C(C)C)nc1OCCOC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
137642741 314117 0 None None None Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 553 9 2 9 4.2 CCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4088349 314117 0 None None None Human 8.2 pIC50 = 8.2 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 553 9 2 9 4.2 CCOc1ccc2c(c1)c(=O)c(Cc1cccc(-c3nnn[nH]3)c1)c(C(=O)O)n2Cc1cc2c(cc1CC)OCO2 10.1016/j.bmcl.2017.04.049
10224228 353503 0 None None None Human 8.1 pIC50 = 8.1 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 424 6 1 6 4.5 Cc1ccc(C)c(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c1 10.1021/jm9700068
CHEMBL47424 353503 0 None None None Human 8.1 pIC50 = 8.1 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 424 6 1 6 4.5 Cc1ccc(C)c(CC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Cl)c1 10.1021/jm9700068
101039204 1466 45 None None None Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/j.bmcl.2017.04.049
443289 1466 45 None None None Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/j.bmcl.2017.04.049
997 1466 45 None None None Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/j.bmcl.2017.04.049
CHEMBL314691 1466 45 None None None Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/j.bmcl.2017.04.049
CHEMBL4095638 1466 45 None None None Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/j.bmcl.2017.04.049
DB12054 1466 45 None None None Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/j.bmcl.2017.04.049
11742628 198520 0 None None None Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 416 5 1 6 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL274383 198520 0 None None None Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 416 5 1 6 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
9845967 25373 0 None None None Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 416 7 1 5 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1016/S0960-894X(97)00002-4
CHEMBL1178000 25373 0 None None None Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 416 7 1 5 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1016/S0960-894X(97)00002-4
52944276 42289 0 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 559 11 3 8 4.1 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCCCO)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1271807 42289 0 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 559 11 3 8 4.1 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCCCO)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
9845967 25373 0 None None None Rat 8.1 pIC50 = 8.1 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 416 7 1 5 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1016/s0960-894x(98)00301-1
CHEMBL1178000 25373 0 None None None Rat 8.1 pIC50 = 8.1 Binding
In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptorIn vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor
ChEMBL 416 7 1 5 4.4 COc1ccc(C(=O)/C(Cc2ccccc2)=C(\C(=O)O)c2ccc3c(c2)OCO3)cc1 10.1016/s0960-894x(98)00301-1
104865 1454 67 None None None Pig 8.1 pIC50 = 8.1 Binding
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm000538f
3494 1454 67 None None None Pig 8.1 pIC50 = 8.1 Binding
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm000538f
392 1454 67 None None None Pig 8.1 pIC50 = 8.1 Binding
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm000538f
CHEMBL957 1454 67 None None None Pig 8.1 pIC50 = 8.1 Binding
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm000538f
DB00559 1454 67 None None None Pig 8.1 pIC50 = 8.1 Binding
Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneAbility to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membrane
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm000538f
10790686 19587 0 None None None Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 474 5 1 8 3.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc3c(c2)OCCO3)cc1 10.1021/jm9606507
CHEMBL10635 19587 0 None None None Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 474 5 1 8 3.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc3c(c2)OCCO3)cc1 10.1021/jm9606507
44458999 332942 0 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 525 6 2 7 3.3 Cn1cc(C(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1016/s0960-894x(01)00660-6
CHEMBL433619 332942 0 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 525 6 2 7 3.3 Cn1cc(C(C(=O)NS(=O)(=O)c2ccc(Cl)cc2)c2ccc3c(c2)OCO3)c2ccc(C(N)=O)cc21 10.1016/s0960-894x(01)00660-6
104865 1454 67 None None None Pig 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(01)00682-5
3494 1454 67 None None None Pig 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(01)00682-5
392 1454 67 None None None Pig 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(01)00682-5
CHEMBL957 1454 67 None None None Pig 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(01)00682-5
DB00559 1454 67 None None None Pig 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0960-894x(01)00682-5
104865 1454 67 None None None Pig 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm0102304
3494 1454 67 None None None Pig 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm0102304
392 1454 67 None None None Pig 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm0102304
CHEMBL957 1454 67 None None None Pig 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm0102304
DB00559 1454 67 None None None Pig 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm0102304
44385593 257395 0 None None None Rat 8.1 pIC50 = 8.1 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 530 10 5 5 4.5 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccc2)nc1C(=O)O 10.1021/jm950592+
CHEMBL367208 257395 0 None None None Rat 8.1 pIC50 = 8.1 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 530 10 5 5 4.5 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccc2)nc1C(=O)O 10.1021/jm950592+
10553316 197398 0 None None None Rat 8.1 pIC50 = 8.1 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 496 11 1 6 4.3 CCCCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL267279 197398 0 None None None Rat 8.1 pIC50 = 8.1 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 496 11 1 6 4.3 CCCCCCN(C)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
44439108 331911 0 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 1267 53 3 22 5.7 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCC(=O)N(C)Cc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2ccno2)cc1 10.1016/j.bmcl.2006.10.009
CHEMBL429019 331911 0 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 1267 53 3 22 5.7 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCCC(=O)N(C)Cc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2ccno2)cc1 10.1016/j.bmcl.2006.10.009
71451527 163109 0 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 641 15 1 12 4.8 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(C2CC2)cn1 10.1021/jm3009103
CHEMBL2163706 163109 0 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 641 15 1 12 4.8 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(C2CC2)cn1 10.1021/jm3009103
71462246 163120 0 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 604 12 2 12 2.6 CNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
CHEMBL2163717 163120 0 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 604 12 2 12 2.6 CNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
10667000 197487 0 None None None Human 8.1 pIC50 = 8.1 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 372 5 1 6 2.8 COc1nc(C)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
CHEMBL268174 197487 0 None None None Human 8.1 pIC50 = 8.1 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 372 5 1 6 2.8 COc1nc(C)cnc1NS(=O)(=O)c1cccc2c(N(C)C)cccc12 10.1021/jm9604585
10765171 22212 0 None None None Human 7.2 pIC50 = 7.2 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 7 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc(OC)c(OC)c3)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL10901 22212 0 None None None Human 7.2 pIC50 = 7.2 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 7 1 6 4.1 COc1ccc(C2(O)OC(=O)C(c3ccc(OC)c(OC)c3)=C2Cc2ccccc2)cc1 10.1021/jm9606507
11798228 198762 1 None None None Human 7.2 pIC50 = 7.2 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 461 6 1 8 3.7 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc([N+](=O)[O-])c2)cc1 10.1021/jm9606507
CHEMBL276018 198762 1 None None None Human 7.2 pIC50 = 7.2 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 461 6 1 8 3.7 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cccc([N+](=O)[O-])c2)cc1 10.1021/jm9606507
9863916 123050 0 None None None Rat 7.2 pIC50 = 7.2 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 365 7 1 5 4.4 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccccc1 10.1021/jm990378b
CHEMBL174229 123050 0 None None None Rat 7.2 pIC50 = 7.2 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 365 7 1 5 4.4 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1ccccc1 10.1021/jm990378b
44320432 473235 0 None None None Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 442 6 1 7 3.6 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1OCCO1 10.1016/s0960-894x(00)00513-8
CHEMBL86821 473235 0 None None None Rat 7.2 pIC50 = 7.2 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 442 6 1 7 3.6 O=C(O)c1c(Cc2cc3c(cc2Cl)OCO3)c(-c2ccccc2)nn1CC1OCCO1 10.1016/s0960-894x(00)00513-8
CHEMBL433893 488597 0 None None None Mouse 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL 895 25 9 8 3.2 CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
9980487 19607 0 None None None Human 6.2 pIC50 = 6.2 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 436 6 1 5 4.8 COc1ccc(CC2=C(c3ccc(Cl)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
CHEMBL10648 19607 0 None None None Human 6.2 pIC50 = 6.2 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 436 6 1 5 4.8 COc1ccc(CC2=C(c3ccc(Cl)cc3)C(=O)OC2(O)c2ccc(OC)cc2)cc1 10.1021/jm9606507
10692351 23698 0 None None None Human 6.2 pIC50 = 6.2 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 400 5 0 5 4.7 COc1ccc(C2OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL11152 23698 0 None None None Human 6.2 pIC50 = 6.2 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 400 5 0 5 4.7 COc1ccc(C2OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccccc2)cc1 10.1021/jm9606507
10894688 468519 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 402 4 1 5 4.4 COc1cccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)c1 10.1021/jm010382z
CHEMBL66246 468519 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 402 4 1 5 4.4 COc1cccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)c1 10.1021/jm010382z
10835638 221053 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 414 6 1 3 5.7 O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1Br)c1ccccc1 10.1021/jm970847e
CHEMBL328057 221053 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 414 6 1 3 5.7 O=C(O)/C(=C/c1cc(OCc2ccsc2)ccc1Br)c1ccccc1 10.1021/jm970847e
10739089 221122 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 389 8 1 4 5.6 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/CCC(=O)O)c1ccccc1 10.1021/jm970847e
CHEMBL328464 221122 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 389 8 1 4 5.6 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/CCC(=O)O)c1ccccc1 10.1021/jm970847e
CHEMBL1793933 484838 0 None None None Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 25 8 8 4.5 CC[C@H](C)[C@H](NC(=O)[C@H]([C@@H](C)CC)N(C)C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm970161m
19010490 106745 0 None None None Human 6.2 pIC50 = 6.2 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 648 13 1 9 6.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)C(C)C)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL16018 106745 0 None None None Human 6.2 pIC50 = 6.2 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 648 13 1 9 6.3 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)C(C)C)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL85341 489392 0 None None None Human 5.2 pIC50 = 5.2 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 863 24 10 9 2.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
127029203 274830 0 None None None Human 5.2 pIC50 = 5.2 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 628 12 3 8 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3753458 274830 0 None None None Human 5.2 pIC50 = 5.2 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 628 12 3 8 5.8 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
18617322 470303 0 None None None Human 7.2 pIC50 = 7.2 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 350 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2ccccc2Cl)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL80438 470303 0 None None None Human 7.2 pIC50 = 7.2 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 350 3 1 4 3.2 Cc1noc(NS(=O)(=O)c2ccccc2Cl)c1Br 10.1016/0960-894X(96)00441-6
44371531 329784 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 467 6 1 5 6.3 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3C(C)C)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL422002 329784 0 None None None Rat 6.2 pIC50 = 6.2 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 467 6 1 5 6.3 COc1ccc(-c2c(C(=O)O)c(=O)n(Cc3ccccc3C(C)C)c3c2oc2ccccc23)cc1 10.1016/s0960-894x(99)00040-2
CHEMBL438768 488741 0 None None None Human 5.2 pIC50 = 5.2 Binding
Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)Binding affinity against Endothelin A receptor in rabbit renal artery vascular smooth muscle membrane (ET-A)
ChEMBL 1868 40 24 25 -1.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)80156-6
CHEMBL2370247 485546 0 None None None Human 5.2 pIC50 = 5.2 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 863 13 8 7 4.1 CC[C@H](C)[C@@H]1NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C(c2ccccc2)c2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]([C@@H](C)CC)NC1=O 10.1021/jm00015a003
127026040 274882 0 None None None Human 5.2 pIC50 = 5.2 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 591 11 3 8 4.6 CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3753888 274882 0 None None None Human 5.2 pIC50 = 5.2 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 591 11 3 8 4.6 CCCc1nc2c(C)cc(C(=O)NCCN3CCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
44298597 200980 0 None None None Rat 4.2 pIC50 = 4.2 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 343 5 2 5 3.0 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1Cc1ccccc1 10.1016/s0960-894x(00)00366-8
CHEMBL293376 200980 0 None None None Rat 4.2 pIC50 = 4.2 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 343 5 2 5 3.0 Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1Cc1ccccc1 10.1016/s0960-894x(00)00366-8
18617333 215220 0 None None None Human 7.1 pIC50 = 7.1 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 424 4 1 5 3.3 COc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL312187 215220 0 None None None Human 7.1 pIC50 = 7.1 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 424 4 1 5 3.3 COc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
44459247 178885 0 None None None Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 575 8 1 7 4.9 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)N(C)C)cc21 10.1016/s0960-894x(01)00660-6
CHEMBL23444 178885 0 None None None Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptorDisplacement of [125I]-labeled ET-1 from human cloned endothelin A (ETA) receptor
ChEMBL 575 8 1 7 4.9 CCn1cc(C(C(=O)NS(=O)(=O)c2ccc(C(C)C)cc2)c2ccc3c(c2)OCO3)c2ccc(C(=O)N(C)C)cc21 10.1016/s0960-894x(01)00660-6
44385127 124128 0 None None None Human 7.1 pIC50 = 7.1 Binding
Tested for the inhibitory activity of cloned human ETA receptor by using I-ET-1 as radioligand in a competitive radioligand assayTested for the inhibitory activity of cloned human ETA receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 482 5 1 7 4.8 Cc1cc2c(cc1/C=C/c1ccsc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00133-9
CHEMBL176854 124128 0 None None None Human 7.1 pIC50 = 7.1 Binding
Tested for the inhibitory activity of cloned human ETA receptor by using I-ET-1 as radioligand in a competitive radioligand assayTested for the inhibitory activity of cloned human ETA receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 482 5 1 7 4.8 Cc1cc2c(cc1/C=C/c1ccsc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00133-9
44316994 469817 0 None None None Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 266 3 1 4 2.4 Cc1cccc(S(=O)(=O)Nc2onc(C)c2C)c1 10.1016/0960-894X(96)00441-6
CHEMBL76420 469817 0 None None None Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 266 3 1 4 2.4 Cc1cccc(S(=O)(=O)Nc2onc(C)c2C)c1 10.1016/0960-894X(96)00441-6
127036866 274674 0 None None None Human 5.1 pIC50 = 5.1 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 614 11 3 8 5.7 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3752117 274674 0 None None None Human 5.1 pIC50 = 5.1 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 614 11 3 8 5.7 CCCc1nc2c(C)cc(C(=O)NCc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
18184256 257403 0 None None None Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 662 13 2 13 3.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL367275 257403 0 None None None Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 662 13 2 13 3.0 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
71458720 163113 0 None None None Human 7.1 pIC50 = 7.1 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 665 13 1 12 4.7 COc1ccccc1Oc1c(NS(=O)(=O)Cc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
CHEMBL2163710 163113 0 None None None Human 7.1 pIC50 = 7.1 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 665 13 1 12 4.7 COc1ccccc1Oc1c(NS(=O)(=O)Cc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncc(Br)cn1 10.1021/jm3009103
44384652 124045 0 None None None Human 7.1 pIC50 = 7.1 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 582 8 1 9 5.2 Cc1noc(NS(=O)(=O)c2sccc2/C=C/c2cc3c(cc2COC2CCOCC2)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
CHEMBL176675 124045 0 None None None Human 7.1 pIC50 = 7.1 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 582 8 1 9 5.2 Cc1noc(NS(=O)(=O)c2sccc2/C=C/c2cc3c(cc2COC2CCOCC2)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
CHEMBL353605 487118 0 None None None Human 6.1 pIC50 = 6.1 Binding
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 541 10 4 5 3.2 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)NC(C)(C)C(=O)O 10.1016/0960-894X(95)00144-I
10672060 23565 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 470 10 1 6 3.4 CCCN(C)C(=O)CN1C[C@H](c2ccc(OC)c(OC)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL110794 23565 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 470 10 1 6 3.4 CCCN(C)C(=O)CN1C[C@H](c2ccc(OC)c(OC)c2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
10626501 256461 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 550 10 5 4 5.1 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C(C)C)[nH]1 10.1021/jm950591h
CHEMBL366745 256461 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 550 10 5 4 5.1 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(C(C)C)[nH]1 10.1021/jm950591h
10721386 123142 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 550 11 5 5 4.8 CCn1cc(C[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)c2nc(C(=O)O)c(C)[nH]2)c2ccccc21 10.1021/jm950592+
CHEMBL174686 123142 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 550 11 5 5 4.8 CCn1cc(C[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)c2nc(C(=O)O)c(C)[nH]2)c2ccccc21 10.1021/jm950592+
10603414 123826 0 None None None Rat 5.1 pIC50 = 5.1 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 585 10 4 5 5.9 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(-c2ccccc2)o1 10.1021/jm950591h
CHEMBL176420 123826 0 None None None Rat 5.1 pIC50 = 5.1 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 585 10 4 5 5.9 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(-c2ccccc2)o1 10.1021/jm950591h
71455061 163102 0 None None None Human 6.1 pIC50 = 6.1 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 511 11 1 12 2.4 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCCOc1ncccn1 10.1021/jm3009103
CHEMBL2163699 163102 0 None None None Human 6.1 pIC50 = 6.1 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 511 11 1 12 2.4 COc1ccccc1Oc1c(NS(C)(=O)=O)nc(-c2ncccn2)nc1OCCOc1ncccn1 10.1021/jm3009103
11826173 467899 0 None None None Rat 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 432 5 1 6 4.5 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC)cc32)cc1 10.1021/jm031041j
CHEMBL62363 467899 0 None None None Rat 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 432 5 1 6 4.5 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC)cc32)cc1 10.1021/jm031041j
11826173 467899 0 None None None Rat 7.1 pIC50 = 7.1 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 432 5 1 6 4.5 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC)cc32)cc1 10.1021/jm010382z
CHEMBL62363 467899 0 None None None Rat 7.1 pIC50 = 7.1 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 432 5 1 6 4.5 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccc(OC)cc32)cc1 10.1021/jm010382z
44385490 259690 0 None None None Rat 7.1 pIC50 = 7.1 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 532 10 4 7 4.2 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccn2)nc1C(=O)O 10.1021/jm950592+
CHEMBL369386 259690 0 None None None Rat 7.1 pIC50 = 7.1 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 532 10 4 7 4.2 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)Nc2ccccn2)nc1C(=O)O 10.1021/jm950592+
10833686 468423 0 None None None Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 380 4 1 7 2.4 COC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(97)00367-3
CHEMBL65531 468423 0 None None None Human 6.1 pIC50 = 6.1 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 380 4 1 7 2.4 COC(=O)c1sccc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/S0960-894X(97)00367-3
44266621 198824 0 None None None Human 5.1 pIC50 = 5.1 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 387 4 1 5 4.7 COc1ccc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(-c3ccccc3)c2c1 10.1016/0960-894X(96)00170-9
CHEMBL276615 198824 0 None None None Human 5.1 pIC50 = 5.1 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 387 4 1 5 4.7 COc1ccc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(-c3ccccc3)c2c1 10.1016/0960-894X(96)00170-9
10722389 26396 0 None None None Human 6.1 pIC50 = 6.1 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 606 10 2 6 6.0 CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1C 10.1021/jm990171i
CHEMBL1184099 26396 0 None None None Human 6.1 pIC50 = 6.1 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 606 10 2 6 6.0 CCc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)c1ccccc1C 10.1021/jm990171i
10621704 122769 0 None None None Rat 7.1 pIC50 = 7.1 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 414 7 1 6 4.8 Cc1ccccc1C(Oc1cc(OCc2ccc3ocnc3c2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL173444 122769 0 None None None Rat 7.1 pIC50 = 7.1 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 414 7 1 6 4.8 Cc1ccccc1C(Oc1cc(OCc2ccc3ocnc3c2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL151361 484708 0 None None None Mouse 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL 848 24 10 9 0.4 CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
44270498 199159 0 None None None Human 7.1 pIC50 = 7.1 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 702 13 1 10 7.2 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(CC(C)C)s1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL279419 199159 0 None None None Human 7.1 pIC50 = 7.1 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 702 13 1 10 7.2 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)NS(=O)(=O)c1ccc(CC(C)C)s1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
10577941 124118 0 None None None Rat 7.1 pIC50 = 7.1 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 522 10 6 4 4.3 Cc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL176794 124118 0 None None None Rat 7.1 pIC50 = 7.1 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 522 10 6 4 4.3 Cc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm950592+
CHEMBL2370070 485516 0 None None None Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cellsDisplacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cells
ChEMBL 848 25 10 9 1.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81215-4
44276596 216501 0 None None None Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 458 8 1 6 4.2 COc1ccc(Cc2[nH]n(Cc3cccc(OC)c3)c(=O)c2Cc2ccc3c(c2)OCO3)cc1 10.1016/s0960-894x(00)00232-8
CHEMBL3144728 216501 0 None None None Rat 5.1 pIC50 = 5.1 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 458 8 1 6 4.2 COc1ccc(Cc2[nH]n(Cc3cccc(OC)c3)c(=O)c2Cc2ccc3c(c2)OCO3)cc1 10.1016/s0960-894x(00)00232-8
10477792 347881 1 None None None Human 4.1 pIC50 = 4.1 Binding
Displacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cellsDisplacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells
ChEMBL 430 8 0 7 3.7 COC[C@@H]1Cc2cc3c(c(OC)c2[C@H](c2ccc(OC)c(OC)c2)[C@H]1COC)OCO3 10.1021/np50124a006
CHEMBL453822 347881 1 None None None Human 4.1 pIC50 = 4.1 Binding
Displacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cellsDisplacement of [125I]endothelin-1 from human recombinant ETA receptor expressed in CHO cells
ChEMBL 430 8 0 7 3.7 COC[C@@H]1Cc2cc3c(c(OC)c2[C@H](c2ccc(OC)c(OC)c2)[C@H]1COC)OCO3 10.1021/np50124a006
10305181 123216 0 None None None Human 6.1 pIC50 = 6.1 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 666 11 2 12 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)NC1CCCCC1 10.1016/s0960-894x(02)01084-3
CHEMBL175278 123216 0 None None None Human 6.1 pIC50 = 6.1 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 666 11 2 12 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)NC1CCCCC1 10.1016/s0960-894x(02)01084-3
10578300 257905 0 None None None Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 537 10 4 6 4.8 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)OC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL367645 257905 0 None None None Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 537 10 4 6 4.8 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)OC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
44279126 200872 0 None None None Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 466 3 2 3 5.5 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccc(Cl)cc3Cl)cc21 10.1016/0960-894X(95)00230-Q
CHEMBL29265 200872 0 None None None Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 466 3 2 3 5.5 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccc(-c3ccc(Cl)cc3Cl)cc21 10.1016/0960-894X(95)00230-Q
44284490 200396 0 None None None Pig 5.1 pIC50 = 5.1 Binding
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL 616 13 3 5 3.9 CNC(=O)[C@H](Cc1ccccn1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)N(C)C(=O)[C@@H](CC(=O)N1CCCCCC1)CC(C)C 10.1021/jm00087a001
CHEMBL288514 200396 0 None None None Pig 5.1 pIC50 = 5.1 Binding
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL 616 13 3 5 3.9 CNC(=O)[C@H](Cc1ccccn1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)N(C)C(=O)[C@@H](CC(=O)N1CCCCCC1)CC(C)C 10.1021/jm00087a001
CHEMBL1206620 484536 0 None None None Pig 5.1 pIC50 = 5.1 Binding
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL 675 14 4 6 3.2 CC(C)C[C@@H](NC(=O)N1CCCCCC1)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccn1)C(=O)N(C)CC(=O)O 10.1021/jm00087a001
CHEMBL287980 484536 0 None None None Pig 5.1 pIC50 = 5.1 Binding
Compound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranesCompound was evaluated for the binding affinity towards Endothelin A receptor in porcine aortic membranes
ChEMBL 675 14 4 6 3.2 CC(C)C[C@@H](NC(=O)N1CCCCCC1)C(=O)N(C)[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccn1)C(=O)N(C)CC(=O)O 10.1021/jm00087a001
44332641 19080 0 None None None Human 4.1 pIC50 = 4.1 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 384 4 0 4 5.2 COC(=O)C(Cc1c2ccccc2cc2ccccc12)c1ccc2c(c1)OCO2 10.1016/S0960-894X(96)00551-3
CHEMBL103731 19080 0 None None None Human 4.1 pIC50 = 4.1 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 384 4 0 4 5.2 COC(=O)C(Cc1c2ccccc2cc2ccccc12)c1ccc2c(c1)OCO2 10.1016/S0960-894X(96)00551-3
10598270 197268 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 421 6 1 5 4.1 CCCC#CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL266144 197268 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 421 6 1 5 4.1 CCCC#CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10744041 197612 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 502 8 1 6 3.9 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)Cc2ccccc2)cc1 10.1021/jm9505369
CHEMBL269108 197612 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 502 8 1 6 3.9 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)N(C)Cc2ccccc2)cc1 10.1021/jm9505369
11101703 332672 0 None None None Rat 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 412 7 1 5 5.3 CCCC[C@@H]1c2cc(OC(C)C)ccc2O[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1021/jm031041j
CHEMBL431372 332672 0 None None None Rat 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 412 7 1 5 5.3 CCCC[C@@H]1c2cc(OC(C)C)ccc2O[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1021/jm031041j
11101703 332672 0 None None None Rat 7.1 pIC50 = 7.1 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 412 7 1 5 5.3 CCCC[C@@H]1c2cc(OC(C)C)ccc2O[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1021/jm010382z
CHEMBL431372 332672 0 None None None Rat 7.1 pIC50 = 7.1 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 412 7 1 5 5.3 CCCC[C@@H]1c2cc(OC(C)C)ccc2O[C@H](c2ccc3c(c2)OCO3)[C@H]1C(=O)O 10.1021/jm010382z
44293736 365900 0 None None None Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 463 7 2 7 4.1 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL49850 365900 0 None None None Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 463 7 2 7 4.1 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL147058 484693 0 None None None Mouse 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL 897 24 10 9 2.5 CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
9874557 257654 0 None None None Human 7.1 pIC50 = 7.1 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 667 15 2 10 5.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL367443 257654 0 None None None Human 7.1 pIC50 = 7.1 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 667 15 2 10 5.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(C2CC2)nc1OCCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
10516176 470060 2 None None None Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 270 3 1 4 2.2 Cc1noc(NS(=O)(=O)c2ccccc2F)c1C 10.1016/0960-894X(96)00441-6
CHEMBL78499 470060 2 None None None Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 270 3 1 4 2.2 Cc1noc(NS(=O)(=O)c2ccccc2F)c1C 10.1016/0960-894X(96)00441-6
44298278 387151 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 462 8 2 7 4.5 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCO)c1 10.1016/s0960-894x(00)00366-8
CHEMBL53168 387151 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 462 8 2 7 4.5 COc1cccc(Sc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)noc2CCO)c1 10.1016/s0960-894x(00)00366-8
10626522 258191 0 None None None Rat 5.1 pIC50 = 5.1 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 551 11 4 5 5.2 CCCc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
CHEMBL367989 258191 0 None None None Rat 5.1 pIC50 = 5.1 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 551 11 4 5 5.2 CCCc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
9961347 26235 1 None None None Human 4.1 pIC50 = 4.1 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 664 13 2 7 6.6 Cc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C 10.1021/jm990171i
CHEMBL1182945 26235 1 None None None Human 4.1 pIC50 = 4.1 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 664 13 2 7 6.6 Cc1ccccc1C(NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OCCOC(C)C)cc1)c1ccccc1C 10.1021/jm990171i
137638953 312764 0 None None None Human 7.1 pIC50 = 7.1 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 579 10 2 9 4.6 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC4CC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4071505 312764 0 None None None Human 7.1 pIC50 = 7.1 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 579 10 2 9 4.6 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC4CC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
11728411 467950 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 372 3 1 4 4.4 O=C(O)C1=C(c2ccccc2)c2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm031041j
CHEMBL62659 467950 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 372 3 1 4 4.4 O=C(O)C1=C(c2ccccc2)c2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm031041j
2529 347569 76 None None None Human 6.1 pIC50 = 6.1 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00029a001
5344 347569 76 None None None Human 6.1 pIC50 = 6.1 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00029a001
CHEMBL453 347569 76 None None None Human 6.1 pIC50 = 6.1 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00029a001
DB00263 347569 76 None None None Human 6.1 pIC50 = 6.1 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00029a001
2529 347569 76 None None None Rat 6.1 pIC50 = 6.1 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00008a013
5344 347569 76 None None None Rat 6.1 pIC50 = 6.1 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00008a013
CHEMBL453 347569 76 None None None Rat 6.1 pIC50 = 6.1 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00008a013
DB00263 347569 76 None None None Rat 6.1 pIC50 = 6.1 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00008a013
11728411 467950 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 372 3 1 4 4.4 O=C(O)C1=C(c2ccccc2)c2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm010382z
CHEMBL62659 467950 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 372 3 1 4 4.4 O=C(O)C1=C(c2ccccc2)c2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm010382z
2529 347569 76 None None None Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm030480f
5344 347569 76 None None None Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm030480f
CHEMBL453 347569 76 None None None Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm030480f
DB00263 347569 76 None None None Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm030480f
10334781 196366 0 None None None Rat 5.1 pIC50 = 5.1 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 297 4 1 6 2.0 Cc1noc(NS(=O)(=O)c2cccc([N+](=O)[O-])c2)c1C 10.1021/jm00008a013
CHEMBL25970 196366 0 None None None Rat 5.1 pIC50 = 5.1 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 297 4 1 6 2.0 Cc1noc(NS(=O)(=O)c2cccc([N+](=O)[O-])c2)c1C 10.1021/jm00008a013
9983872 201837 0 None None None Rat 5.1 pIC50 = 5.1 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 511 9 2 5 6.9 Cc1noc(NS(=O)(=O)c2cccc3c(NCCC(c4ccccc4)c4ccccc4)cccc23)c1C 10.1021/jm00008a013
CHEMBL29954 201837 0 None None None Rat 5.1 pIC50 = 5.1 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 511 9 2 5 6.9 Cc1noc(NS(=O)(=O)c2cccc3c(NCCC(c4ccccc4)c4ccccc4)cccc23)c1C 10.1021/jm00008a013
10336018 202201 0 None None None Rat 5.1 pIC50 = 5.1 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 318 3 2 5 3.0 Cc1noc(NS(=O)(=O)c2cccc3c(O)cccc23)c1C 10.1021/jm00008a013
CHEMBL30228 202201 0 None None None Rat 5.1 pIC50 = 5.1 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 318 3 2 5 3.0 Cc1noc(NS(=O)(=O)c2cccc3c(O)cccc23)c1C 10.1021/jm00008a013
CHEMBL413825 488300 0 None None None Human 5.1 pIC50 = 5.1 Binding
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptorBinding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor
ChEMBL 2042 37 25 23 -2.3 C[C@@H]1NC(=O)[C@@H]([C@@H](C)O)NC(=O)CNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)NC(=O)[C@H]2CCCN2C1=O 10.1016/0960-894X(95)00084-7
10840422 259253 0 None None None Rat 5.1 pIC50 = 5.1 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 550 11 5 4 4.9 CCCc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
CHEMBL368854 259253 0 None None None Rat 5.1 pIC50 = 5.1 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 550 11 5 4 4.9 CCCc1[nH]c([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1C(=O)O 10.1021/jm950591h
10624915 473215 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 490 6 2 6 4.5 COc1ccc(NC(=O)N2C[C@@H](c3ccc4c(c3)OCO4)[C@H](C(=O)O)[C@H]2c2ccc(OC)cc2)cc1 10.1021/jm9505369
CHEMBL8671 473215 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 490 6 2 6 4.5 COc1ccc(NC(=O)N2C[C@@H](c3ccc4c(c3)OCO4)[C@H](C(=O)O)[C@H]2c2ccc(OC)cc2)cc1 10.1021/jm9505369
18617288 470008 0 None None None Human 7.1 pIC50 = 7.1 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 316 3 1 4 2.5 Cc1noc(NS(=O)(=O)c2ccccc2)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL78080 470008 0 None None None Human 7.1 pIC50 = 7.1 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 316 3 1 4 2.5 Cc1noc(NS(=O)(=O)c2ccccc2)c1Br 10.1016/0960-894X(96)00441-6
44320444 473410 0 None None None Rat 7.1 pIC50 = 7.1 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 481 7 2 8 4.0 O=C(O)c1cc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)on1 10.1016/s0960-894x(00)00513-8
CHEMBL88019 473410 0 None None None Rat 7.1 pIC50 = 7.1 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 481 7 2 8 4.0 O=C(O)c1cc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)on1 10.1016/s0960-894x(00)00513-8
CHEMBL146866 484692 0 None None None Mouse 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL 920 24 10 8 3.3 CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
44384651 256439 0 None None None Human 7.1 pIC50 = 7.1 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 498 6 2 8 4.0 Cc1noc(NS(=O)(=O)c2sccc2/C=C/c2cc3c(cc2CO)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
CHEMBL366680 256439 0 None None None Human 7.1 pIC50 = 7.1 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 498 6 2 8 4.0 Cc1noc(NS(=O)(=O)c2sccc2/C=C/c2cc3c(cc2CO)OCO3)c1Br 10.1016/S0960-894X(97)00133-9
44332624 18530 0 None None None Human 5.1 pIC50 = 5.1 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 356 3 1 4 3.7 NC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL100120 18530 0 None None None Human 5.1 pIC50 = 5.1 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 356 3 1 4 3.7 NC(=O)C(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
10743872 197520 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 496 13 1 6 5.2 CCCCN(CCCC)CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL268432 197520 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 496 13 1 6 5.2 CCCCN(CCCC)CCN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
3847484 468723 1 None None None Human 5.1 pIC50 = 5.1 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 360 4 1 3 4.4 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)cc3)cccc12 10.1021/jm9604585
CHEMBL6778 468723 1 None None None Human 5.1 pIC50 = 5.1 Binding
Inhibition of specific binding of [125-I]ET-1 to human endothelin A receptorInhibition of specific binding of [125-I]ET-1 to human endothelin A receptor
ChEMBL 360 4 1 3 4.4 CN(C)c1cccc2c(S(=O)(=O)Nc3ccc(Cl)cc3)cccc12 10.1021/jm9604585
10145418 163101 0 None None None Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 601 14 1 12 4.0 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncccn1 10.1016/j.bmcl.2016.06.014
CHEMBL2163698 163101 0 None None None Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at ETA receptor (unknown origin)Antagonist activity at ETA receptor (unknown origin)
ChEMBL 601 14 1 12 4.0 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncccn1 10.1016/j.bmcl.2016.06.014
CHEMBL354082 487120 0 None None None Human 8.1 pIC50 = 8.1 Binding
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 543 11 5 6 1.8 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)N[C@H](CO)C(=O)O 10.1016/0960-894X(95)00144-I
CHEMBL354152 487121 0 None None None Human 8.1 pIC50 = 8.1 Binding
Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.Binding affinity against ETA receptor from dog spleen membranes using [125I]ET1 as radioligand.
ChEMBL 656 12 4 6 4.5 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)N[C@H](Cc1cn(C)c2ccccc12)C(=O)O 10.1016/0960-894X(95)00144-I
10646372 19787 0 None None None Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 5 2 7 3.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(O)cc2)cc1 10.1021/jm9606507
CHEMBL10744 19787 0 None None None Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 432 5 2 7 3.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc(O)cc2)cc1 10.1021/jm9606507
10950392 468012 0 None None None Rat 8.1 pIC50 = 8.1 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 448 5 1 5 5.4 CC(C)Oc1ccc2c(c1)C(c1ccc(F)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
CHEMBL62966 468012 0 None None None Rat 8.1 pIC50 = 8.1 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 448 5 1 5 5.4 CC(C)Oc1ccc2c(c1)C(c1ccc(F)cc1)=C(C(=O)O)C(c1ccc3c(c1)OCO3)O2 10.1021/jm010382z
11113542 468246 0 None None None Rat 8.1 pIC50 = 8.1 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 476 8 1 6 5.5 COc1ccc(C2=C(C(=O)O)C(c3ccc(OC)cc3OC)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
CHEMBL64398 468246 0 None None None Rat 8.1 pIC50 = 8.1 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 476 8 1 6 5.5 COc1ccc(C2=C(C(=O)O)C(c3ccc(OC)cc3OC)Oc3ccc(OC(C)C)cc32)cc1 10.1021/jm010382z
44314575 213299 0 None None None Pig 8.1 pIC50 = 8.1 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 601 13 5 5 4.2 CSCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL308584 213299 0 None None None Pig 8.1 pIC50 = 8.1 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 601 13 5 5 4.2 CSCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
22010244 473746 0 None None None Rat 8.1 pIC50 = 8.1 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 407 9 1 5 5.5 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C#N 10.1021/jm970847e
CHEMBL90320 473746 0 None None None Rat 8.1 pIC50 = 8.1 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 407 9 1 5 5.5 Cc1ccccc1C(CCC(=O)O)Oc1cc(OCc2ccsc2)ccc1C#N 10.1021/jm970847e
44439106 309710 0 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 1005 37 2 17 5.8 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOCCOCCOCCC(=O)N(C)Cc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2ccno2)cc1 10.1016/j.bmcl.2006.10.009
CHEMBL398070 309710 0 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]ET1 from human ETA receptor expressed in CHO cellsDisplacement of [125I]ET1 from human ETA receptor expressed in CHO cells
ChEMBL 1005 37 2 17 5.8 CC(=O)CC(=O)CCc1ccc(NC(=O)CCOCCOCCOCCOCCOCCOCCOCCC(=O)N(C)Cc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2ccno2)cc1 10.1016/j.bmcl.2006.10.009
10145418 163101 0 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 601 14 1 12 4.0 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncccn1 10.1021/jm3009103
CHEMBL2163698 163101 0 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 601 14 1 12 4.0 COc1ccccc1Oc1c(NS(=O)(=O)CCc2ccccc2)nc(-c2ncccn2)nc1OCCOc1ncccn1 10.1021/jm3009103
44304492 196896 0 None None None Pig 8.1 pIC50 = 8.1 Binding
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL 949 23 9 8 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
CHEMBL262993 196896 0 None None None Pig 8.1 pIC50 = 8.1 Binding
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL 949 23 9 8 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
CHEMBL265614 484236 17 None None None Pig 8.1 pIC50 = 8.1 Binding
Inhibition of endothelin (ET-A) binding to porcine heart membranes Inhibition of endothelin (ET-A) binding to porcine heart membranes
ChEMBL 949 23 9 8 4.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(C)=O)C1c2ccccc2CCc2ccccc21)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00349-X
104865 1454 67 None None None Human 8.1 pIC50 = 8.1 Binding
Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cellsReceptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
3494 1454 67 None None None Human 8.1 pIC50 = 8.1 Binding
Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cellsReceptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
392 1454 67 None None None Human 8.1 pIC50 = 8.1 Binding
Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cellsReceptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
CHEMBL957 1454 67 None None None Human 8.1 pIC50 = 8.1 Binding
Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cellsReceptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
DB00559 1454 67 None None None Human 8.1 pIC50 = 8.1 Binding
Receptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cellsReceptor binding affinity was determined in a radioligand binding assay against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
10230835 219771 0 None None None Rat 8.1 pIC50 = 8.1 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 546 12 1 7 4.0 CCCS(=O)(=O)N(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)CC(C)C 10.1021/jm970101g
CHEMBL323789 219771 0 None None None Rat 8.1 pIC50 = 8.1 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 546 12 1 7 4.0 CCCS(=O)(=O)N(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)CC(C)C 10.1021/jm970101g
10383884 470067 0 None None None Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 359 4 2 5 2.9 CNc1ccc(C)cc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
CHEMBL78563 470067 0 None None None Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 359 4 2 5 2.9 CNc1ccc(C)cc1S(=O)(=O)Nc1onc(C)c1Br 10.1016/0960-894X(96)00441-6
44314660 214083 0 None None None Pig 8.1 pIC50 = 8.1 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 633 13 5 4 4.7 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCC1C)C(=O)O 10.1021/jm9600914
CHEMBL310111 214083 0 None None None Pig 8.1 pIC50 = 8.1 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 633 13 5 4 4.7 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCC1C)C(=O)O 10.1021/jm9600914
CHEMBL2304011 485313 0 None None None Pig 8.1 pIC50 = 8.1 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 608 6 6 6 0.5 Cc1[nH]c2ccccc2c1C[C@@H]1NC(=O)[C@@H](C2CC2)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC1=O 10.1021/jm9600914
10766385 198698 0 None None None Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 460 6 1 7 4.1 COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2ccccc2)cc1C 10.1021/jm9606507
CHEMBL275559 198698 0 None None None Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 460 6 1 7 4.1 COc1ccc(C2(O)OC(=O)C(c3cc(OC)c4c(c3)OCO4)=C2Cc2ccccc2)cc1C 10.1021/jm9606507
44333889 19422 0 None None None Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 463 7 1 6 5.3 CCCSc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
CHEMBL105494 19422 0 None None None Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against I-labeled ET-1 binding to Endothelin A receptorInhibitory activity against I-labeled ET-1 binding to Endothelin A receptor
ChEMBL 463 7 1 6 5.3 CCCSc1ccc2c(n1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(02)00663-7
10647373 197295 0 None None None Rat 8.1 pIC50 = 8.1 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 454 8 2 6 3.0 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)NCC(C)C)cc1 10.1021/jm9505369
CHEMBL266337 197295 0 None None None Rat 8.1 pIC50 = 8.1 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 454 8 2 6 3.0 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CC(=O)NCC(C)C)cc1 10.1021/jm9505369
10817057 23998 0 None None None Rat 8.1 pIC50 = 8.1 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 580 11 1 7 4.7 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccc(C)cc1 10.1021/jm970101g
CHEMBL113087 23998 0 None None None Rat 8.1 pIC50 = 8.1 Binding
Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.Ability to displace endothelin ([125I]ET1) from endothelin A receptor derived from MMQ cells of rodent.
ChEMBL 580 11 1 7 4.7 CCCN(CCN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1)S(=O)(=O)c1ccc(C)cc1 10.1021/jm970101g
9840391 214256 4 None None None Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 328 4 1 4 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL310427 214256 4 None None None Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 328 4 1 4 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1C 10.1016/0960-894X(96)00441-6
9803428 202293 0 None None None Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 442 5 1 9 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1Cl 10.1016/S0960-894X(97)00367-3
CHEMBL302872 202293 0 None None None Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 442 5 1 9 3.4 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1Cl 10.1016/S0960-894X(97)00367-3
CHEMBL336033 484275 0 None None None Human 8.1 pIC50 = 8.1 Binding
Inhibitory effect against Human Endothelin A receptorInhibitory effect against Human Endothelin A receptor
ChEMBL 610 7 6 6 0.8 CC(C)C[C@H]1NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm00021a021
104865 1454 67 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1039/C5MD00169B
3494 1454 67 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1039/C5MD00169B
392 1454 67 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1039/C5MD00169B
CHEMBL957 1454 67 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1039/C5MD00169B
DB00559 1454 67 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1039/C5MD00169B
10504689 23745 0 None None None Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 474 6 1 8 3.6 COC(=O)c1cccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)c1 10.1021/jm9606507
CHEMBL11176 23745 0 None None None Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 474 6 1 8 3.6 COC(=O)c1cccc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OC)cc2)c1 10.1021/jm9606507
10840410 469010 0 None None None Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 550 10 2 10 3.3 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCC(=O)O)c2)cc1 10.1021/jm980504w
CHEMBL70017 469010 0 None None None Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.Inhibition of [125I]-ET-1 binding to recombinant human Endothelin A receptor.
ChEMBL 550 10 2 10 3.3 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCC(=O)O)c2)cc1 10.1021/jm980504w
CHEMBL2304006 485308 0 None None None Human 8.1 pIC50 = 8.1 Binding
Binding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranesBinding affinity towards Endothelin A receptor in human neuroblastoma-derived cell line SK-N-MC membranes
ChEMBL 698 6 6 6 1.5 O=C(O)C[C@H]1NC(=O)[C@H](Cc2c(Br)[nH]c3ccccc23)NC(=O)[C@@H](C2CC2)NC(=O)[C@H](C2CCCC2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm9600914
CHEMBL411171 488158 0 None None None Pig 8.1 pIC50 = 8.1 Binding
Tested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptorTested for the competitive binding versus [125I]- ET-1 determined in porcine cardiac ventricular membrane for Endothelin A receptor
ChEMBL 2488 47 31 35 -3.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CO)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00077a013
22467266 176293 0 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 522 7 2 8 3.4 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 10.1007/s00044-004-0021-y
76312118 176293 0 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 522 7 2 8 3.4 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261360 176293 0 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 522 7 2 8 3.4 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261361 176293 0 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 522 7 2 8 3.4 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 10.1007/s00044-004-0021-y
10626362 25728 0 None None None Human 8.1 pIC50 = 8.1 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 544 8 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 10.1021/jm990171i
CHEMBL1180351 25728 0 None None None Human 8.1 pIC50 = 8.1 Binding
Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptorBinding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor
ChEMBL 544 8 2 6 5.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)NC(c2ccccc2)C(C)(C)C)cc1 10.1021/jm990171i
22467230 176301 0 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 536 8 1 8 4.0 COCc1ccc2c(C(C(=O)NS(=O)(=O)c3ccc(C)cc3OC)c3ccc4c(c3)OCO4)cn(C)c2c1 10.1007/s00044-004-0021-y
CHEMBL2261601 176301 0 None None None Human 8.1 pIC50 = 8.1 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 536 8 1 8 4.0 COCc1ccc2c(C(C(=O)NS(=O)(=O)c3ccc(C)cc3OC)c3ccc4c(c3)OCO4)cn(C)c2c1 10.1007/s00044-004-0021-y
11038925 24161 0 None None None Pig 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 550 11 1 9 5.2 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ccccn2)c1 10.1021/jm0102304
CHEMBL114105 24161 0 None None None Pig 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 550 11 1 9 5.2 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCOc2ccccn2)c1 10.1021/jm0102304
9826741 200903 0 None None None Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 486 5 1 9 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00367-3
CHEMBL292802 200903 0 None None None Human 8.1 pIC50 = 8.1 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 486 5 1 9 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00367-3
9826741 200903 0 None None None Human 8.1 pIC50 = 8.1 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 486 5 1 9 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00132-7
CHEMBL292802 200903 0 None None None Human 8.1 pIC50 = 8.1 Binding
Inhibition of I-ET-1 binding to human Endothelin A receptorInhibition of I-ET-1 binding to human Endothelin A receptor
ChEMBL 486 5 1 9 3.6 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Oc2ccc3c(c2)OCO3)c1Br 10.1016/S0960-894X(97)00132-7
10068813 198326 10 None None None Rat 7.1 pIC50 = 7.1 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 387 8 2 5 4.8 CCCCCNc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
CHEMBL27299 198326 10 None None None Rat 7.1 pIC50 = 7.1 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 387 8 2 5 4.8 CCCCCNc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
104865 1454 67 None None None Human 7.1 pIC50 = 7.1 Binding
Binding affinity to recombinant human ETABinding affinity to recombinant human ETA
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.0c01093
3494 1454 67 None None None Human 7.1 pIC50 = 7.1 Binding
Binding affinity to recombinant human ETABinding affinity to recombinant human ETA
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.0c01093
392 1454 67 None None None Human 7.1 pIC50 = 7.1 Binding
Binding affinity to recombinant human ETABinding affinity to recombinant human ETA
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.0c01093
CHEMBL957 1454 67 None None None Human 7.1 pIC50 = 7.1 Binding
Binding affinity to recombinant human ETABinding affinity to recombinant human ETA
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.0c01093
DB00559 1454 67 None None None Human 7.1 pIC50 = 7.1 Binding
Binding affinity to recombinant human ETABinding affinity to recombinant human ETA
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/acs.jmedchem.0c01093
10406285 221145 1 None None None Rat 7.1 pIC50 = 7.1 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 361 6 1 4 4.8 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/C(=O)O)c1ccccc1 10.1021/jm970847e
CHEMBL328600 221145 1 None None None Rat 7.1 pIC50 = 7.1 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 361 6 1 4 4.8 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/C(=O)O)c1ccccc1 10.1021/jm970847e
104865 1454 67 None None None Human 7.1 pIC50 = 7.1 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
3494 1454 67 None None None Human 7.1 pIC50 = 7.1 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
392 1454 67 None None None Human 7.1 pIC50 = 7.1 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
CHEMBL957 1454 67 None None None Human 7.1 pIC50 = 7.1 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
DB00559 1454 67 None None None Human 7.1 pIC50 = 7.1 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
18184229 122384 0 None None None Human 7.1 pIC50 = 7.1 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 605 15 2 10 4.2 CCCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL171950 122384 0 None None None Human 7.1 pIC50 = 7.1 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 605 15 2 10 4.2 CCCS(=O)(=O)NCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
44266552 18860 0 None None None Human 7.1 pIC50 = 7.1 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL10218 18860 0 None None None Human 7.1 pIC50 = 7.1 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 473 7 1 7 5.3 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
44266567 198518 0 None None None Human 7.1 pIC50 = 7.1 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 461 5 1 8 4.5 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(-c3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00170-9
CHEMBL274368 198518 0 None None None Human 7.1 pIC50 = 7.1 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 461 5 1 8 4.5 COc1cc2c(-c3ccc4c(c3)OCO4)c(C(=O)O)n(-c3ccc4c(c3)OCO4)c2cc1OC 10.1016/0960-894X(96)00170-9
104865 1454 67 None None None Human 7.1 pIC50 = 7.1 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
3494 1454 67 None None None Human 7.1 pIC50 = 7.1 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
392 1454 67 None None None Human 7.1 pIC50 = 7.1 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
CHEMBL957 1454 67 None None None Human 7.1 pIC50 = 7.1 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
DB00559 1454 67 None None None Human 7.1 pIC50 = 7.1 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/S0960-894X(97)00400-9
19432672 469146 0 None None None Human 7.1 pIC50 = 7.1 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 606 11 3 9 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCNC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
CHEMBL70924 469146 0 None None None Human 7.1 pIC50 = 7.1 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 606 11 3 9 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCNC(=O)Nc1ccccn1 10.1016/S0960-894X(97)00400-9
10623877 22802 0 None None None Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 461 6 1 8 3.7 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc([N+](=O)[O-])cc2)cc1 10.1021/jm9606507
CHEMBL10940 22802 0 None None None Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 461 6 1 8 3.7 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2ccc([N+](=O)[O-])cc2)cc1 10.1021/jm9606507
11015023 202780 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 406 3 1 4 5.1 O=C(O)C1=C(c2ccc(Cl)cc2)c2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm010382z
CHEMBL304875 202780 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 406 3 1 4 5.1 O=C(O)C1=C(c2ccc(Cl)cc2)c2ccccc2OC1c1ccc2c(c1)OCO2 10.1021/jm010382z
19095644 334281 0 None None None Human 6.1 pIC50 = 6.1 Binding
Binding affinity to recombinant human ETABinding affinity to recombinant human ETA
ChEMBL 549 10 2 8 5.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ccccc2)nc1OCCO 10.1021/acs.jmedchem.0c01093
CHEMBL4438132 334281 0 None None None Human 6.1 pIC50 = 6.1 Binding
Binding affinity to recombinant human ETABinding affinity to recombinant human ETA
ChEMBL 549 10 2 8 5.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ccccc2)nc1OCCO 10.1021/acs.jmedchem.0c01093
14041110 200193 0 None None None Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 322 2 2 3 2.5 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccccc21 10.1016/0960-894X(95)00230-Q
CHEMBL286808 200193 0 None None None Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards cloned human ETA receptorBinding affinity towards cloned human ETA receptor
ChEMBL 322 2 2 3 2.5 O=C1c2ccccc2[C@@H]2[C@H](C(=O)O)[C@H](C(=O)O)[C@@H]2c2ccccc21 10.1016/0960-894X(95)00230-Q
10497859 328403 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 347 6 1 4 4.7 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/CO)c1ccccc1 10.1021/jm970847e
CHEMBL419694 328403 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 347 6 1 4 4.7 N#Cc1ccc(OCc2ccsc2)cc1/C=C(/CO)c1ccccc1 10.1021/jm970847e
44298325 391294 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 446 7 1 6 5.5 CCc1onc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Sc1cccc(OC)c1 10.1016/s0960-894x(00)00366-8
CHEMBL55664 391294 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 446 7 1 6 5.5 CCc1onc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Sc1cccc(OC)c1 10.1016/s0960-894x(00)00366-8
19095644 334281 0 None None None Human 6.1 pIC50 = 6.1 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 549 10 2 8 5.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ccccc2)nc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL4438132 334281 0 None None None Human 6.1 pIC50 = 6.1 Binding
Displacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranesDisplacement of radioligand from ETA receptor (unknown origin) expressed in fall armyworm sf9 cell membranes
ChEMBL 549 10 2 8 5.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ccccc2)nc1OCCO 10.1016/j.bmcl.2016.06.014
2529 347569 76 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00004a012
5344 347569 76 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00004a012
CHEMBL453 347569 76 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00004a012
DB00263 347569 76 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1021/jm00004a012
44386621 124037 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 549 10 4 6 4.5 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O 10.1021/jm950592+
CHEMBL176653 124037 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 549 10 4 6 4.5 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CC3CCC2C3)nc1C(=O)O 10.1021/jm950592+
44266542 318289 0 None None None Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 521 7 1 7 6.1 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc(OCc3ccccc3)ccc2n1Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
CHEMBL417246 318289 0 None None None Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration to the endothelin A receptor expressed in LtK cellsInhibitory concentration to the endothelin A receptor expressed in LtK cells
ChEMBL 521 7 1 7 6.1 O=C(O)c1c(-c2ccc3c(c2)OCO3)c2cc(OCc3ccccc3)ccc2n1Cc1ccc2c(c1)OCO2 10.1016/0960-894X(96)00170-9
44368428 97862 0 None None None Pig 5.1 pIC50 = 5.1 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 521 9 2 5 5.5 O=C(O)C(Cc1ccc(O)cc1)N(Cc1ccccc1-c1ccccc1)C(=O)/C=C/c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00009-9
CHEMBL152001 97862 0 None None None Pig 5.1 pIC50 = 5.1 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 521 9 2 5 5.5 O=C(O)C(Cc1ccc(O)cc1)N(Cc1ccccc1-c1ccccc1)C(=O)/C=C/c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00009-9
CHEMBL330489 486738 0 None None None Human 5.1 pIC50 = 5.1 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 506 12 5 4 2.6 CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00070a001
CHEMBL86737 489394 0 None None None Human 5.1 pIC50 = 5.1 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 805 22 9 8 1.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00070a001
CHEMBL330489 486738 0 None None None Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cellsDisplacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cells
ChEMBL 506 12 5 4 2.6 CC[C@H](C)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/S0960-894X(01)81215-4
10627378 123190 0 None None None Rat 5.1 pIC50 = 5.1 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 598 11 5 4 5.6 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(Cc2ccccc2)[nH]1 10.1021/jm950591h
CHEMBL175103 123190 0 None None None Rat 5.1 pIC50 = 5.1 Binding
Inhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranesInhibition of Endothelin-1 binding to Endothelin A receptor binding sites in MMQ cell membranes
ChEMBL 598 11 5 4 5.6 CC(C)C[C@H](NC(=O)N1CCCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nc(C(=O)O)c(Cc2ccccc2)[nH]1 10.1021/jm950591h
18995996 199421 0 None None None Human 7.1 pIC50 = 7.1 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 569 10 1 8 6.9 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OCc4ccccc4)cc23)c1 10.1016/0960-894X(96)00232-6
CHEMBL281451 199421 0 None None None Human 7.1 pIC50 = 7.1 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 569 10 1 8 6.9 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc(OC)c(OCc4ccccc4)cc23)c1 10.1016/0960-894X(96)00232-6
44279366 199855 0 None None None Pig 7.1 pIC50 = 7.1 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 499 11 5 4 2.4 CC(C)C[C@H](NC(=O)N1CCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL284392 199855 0 None None None Pig 7.1 pIC50 = 7.1 Binding
Binding affinity determined against ETA receptor in porcine aortic smooth muscle membraneBinding affinity determined against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 499 11 5 4 2.4 CC(C)C[C@H](NC(=O)N1CCCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
44384757 330993 0 None None None Human 7.1 pIC50 = 7.1 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 482 5 1 7 4.8 Cc1cc2c(cc1/C=C/c1sccc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00133-9
CHEMBL426218 330993 0 None None None Human 7.1 pIC50 = 7.1 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 482 5 1 7 4.8 Cc1cc2c(cc1/C=C/c1sccc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00133-9
11103152 328234 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 504 9 1 7 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)c(OC)c1)O2 10.1021/jm010382z
CHEMBL418473 328234 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 504 9 1 7 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)c(OC)c1)O2 10.1021/jm010382z
44314580 469999 0 None None None Pig 6.1 pIC50 = 6.1 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 608 13 5 5 4.5 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C(C)C)C(=O)O 10.1021/jm9600914
CHEMBL78023 469999 0 None None None Pig 6.1 pIC50 = 6.1 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 608 13 5 5 4.5 CCCCC(NC(=O)[C@@H](Cc1c(C#N)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C(C)C(C)C)C(=O)O 10.1021/jm9600914
CHEMBL441006 488815 0 None None None Human 5.1 pIC50 = 5.1 Binding
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptorBinding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor
ChEMBL 1123 28 12 11 4.1 CC(=O)[C@H](Cc1c[nH]c2ccccc12)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00084-7
23445388 473482 0 None None None Human 6.1 pIC50 = 6.1 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 398 4 1 5 4.3 Cc1noc(NS(=O)(=O)c2sccc2-c2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL88506 473482 0 None None None Human 6.1 pIC50 = 6.1 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 398 4 1 5 4.3 Cc1noc(NS(=O)(=O)c2sccc2-c2ccccc2)c1Br 10.1016/S0960-894X(96)00496-9
9917072 124853 0 None None None Human 7.1 pIC50 = 7.1 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 619 16 2 10 4.6 CCCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
CHEMBL177538 124853 0 None None None Human 7.1 pIC50 = 7.1 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 619 16 2 10 4.6 CCCS(=O)(=O)NCCCOc1nc(C2CC2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01083-1
23445408 221128 0 None None None Human 7.1 pIC50 = 7.1 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 454 6 1 5 5.5 Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(CC(C)C)cc2)c1Br 10.1016/S0960-894X(96)00496-9
CHEMBL328517 221128 0 None None None Human 7.1 pIC50 = 7.1 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 454 6 1 5 5.5 Cc1noc(NS(=O)(=O)c2sccc2-c2ccc(CC(C)C)cc2)c1Br 10.1016/S0960-894X(96)00496-9
44270602 199097 0 None None None Human 6.1 pIC50 = 6.1 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 688 13 1 10 7.0 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1cccs1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL278930 199097 0 None None None Human 6.1 pIC50 = 6.1 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 688 13 1 10 7.0 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)cc(CCC)c1OC(C(=O)NS(=O)(=O)c1cccs1)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
1009 399 28 None None None Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.1021/jm990170q
5310991 399 28 None None None Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.1021/jm990170q
CHEMBL332794 399 28 None None None Human 5.1 pIC50 = 5.1 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.1021/jm990170q
44383535 122061 0 None None None Human 5.1 pIC50 = 5.1 Binding
Tested for binding affinity towards human Endothelin A receptorTested for binding affinity towards human Endothelin A receptor
ChEMBL 280 4 1 5 1.5 C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(OC)[C@]2(O)CC1 10.1016/s0960-894x(00)00136-0
CHEMBL170446 122061 0 None None None Human 5.1 pIC50 = 5.1 Binding
Tested for binding affinity towards human Endothelin A receptorTested for binding affinity towards human Endothelin A receptor
ChEMBL 280 4 1 5 1.5 C/C=C/C=C/C(=O)O[C@@H]1C=C2COC(OC)[C@]2(O)CC1 10.1016/s0960-894x(00)00136-0
10960638 201205 0 None None None Rat 7.1 pIC50 = 7.1 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 414 4 1 4 5.6 CC(C)c1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)cc1 10.1021/jm010382z
CHEMBL294793 201205 0 None None None Rat 7.1 pIC50 = 7.1 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 414 4 1 4 5.6 CC(C)c1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)cc1 10.1021/jm010382z
23445358 221060 0 None None None Human 6.1 pIC50 = 6.1 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 412 4 1 5 4.6 Cc1cccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/S0960-894X(96)00496-9
CHEMBL328089 221060 0 None None None Human 6.1 pIC50 = 6.1 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 412 4 1 5 4.6 Cc1cccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1016/S0960-894X(96)00496-9
10546830 201503 0 None None None Human 6.1 pIC50 = 6.1 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 365 4 2 6 1.7 Cc1noc(NS(=O)(=O)c2ccsc2C(N)=O)c1Br 10.1021/jm9608366
CHEMBL297107 201503 0 None None None Human 6.1 pIC50 = 6.1 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 365 4 2 6 1.7 Cc1noc(NS(=O)(=O)c2ccsc2C(N)=O)c1Br 10.1021/jm9608366
44386069 122513 0 None None None Human 5.1 pIC50 = 5.1 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 704 13 2 11 5.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
CHEMBL172441 122513 0 None None None Human 5.1 pIC50 = 5.1 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 704 13 2 11 5.5 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCNS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(02)01083-1
18995999 198777 0 None None None Human 7.1 pIC50 = 7.1 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 477 6 1 8 5.0 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)c1 10.1016/0960-894X(96)00232-6
CHEMBL27617 198777 0 None None None Human 7.1 pIC50 = 7.1 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 477 6 1 8 5.0 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3cc4c(cc23)OCO4)c1 10.1016/0960-894X(96)00232-6
44384611 256590 0 None None None Human 7.1 pIC50 = 7.1 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 644 10 2 12 5.8 C#CCOc1nc(-c2ccnc(-c3noc(S)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL366797 256590 0 None None None Human 7.1 pIC50 = 7.1 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 644 10 2 12 5.8 C#CCOc1nc(-c2ccnc(-c3noc(S)n3)c2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10405292 197879 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3cc(N(C)C)ccc23)c1C 10.1021/jm00008a013
CHEMBL27073 197879 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3cc(N(C)C)ccc23)c1C 10.1021/jm00008a013
44316526 470266 1 None None None Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 344 3 1 4 3.2 Cc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C 10.1016/0960-894X(96)00441-6
CHEMBL80180 470266 1 None None None Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 344 3 1 4 3.2 Cc1ccc(Br)cc1S(=O)(=O)Nc1onc(C)c1C 10.1016/0960-894X(96)00441-6
10674642 232419 0 None None None Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 574 10 3 7 4.7 CCc1cc(C(=O)O)cc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
CHEMBL331758 232419 0 None None None Human 6.1 pIC50 = 6.1 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 574 10 3 7 4.7 CCc1cc(C(=O)O)cc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
10405292 197879 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3cc(N(C)C)ccc23)c1C 10.1021/jm00004a012
CHEMBL27073 197879 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3cc(N(C)C)ccc23)c1C 10.1021/jm00004a012
19010508 119145 0 None None None Human 6.1 pIC50 = 6.1 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 501 9 1 7 5.5 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
CHEMBL16306 119145 0 None None None Human 6.1 pIC50 = 6.1 Binding
Inhibition of human endothelin A (ETA) receptor expressed in CHO cellsInhibition of human endothelin A (ETA) receptor expressed in CHO cells
ChEMBL 501 9 1 7 5.5 CCCc1cc(Cn2c(CC)nc3c(C)cc(C)nc32)ccc1OC(C(=O)O)c1ccc2c(c1)OCO2 10.1016/0960-894X(95)00186-W
14973488 232835 0 None None None Human 4.1 pIC50 = 4.1 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 295 4 1 5 2.2 Cc1noc(NS(=O)(=O)c2ccc(N(C)C)cc2)c1C 10.1021/jm00029a001
CHEMBL332471 232835 0 None None None Human 4.1 pIC50 = 4.1 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 295 4 1 5 2.2 Cc1noc(NS(=O)(=O)c2ccc(N(C)C)cc2)c1C 10.1021/jm00029a001
14973488 232835 0 None None None Rat 4.1 pIC50 = 4.1 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 295 4 1 5 2.2 Cc1noc(NS(=O)(=O)c2ccc(N(C)C)cc2)c1C 10.1021/jm00004a012
CHEMBL332471 232835 0 None None None Rat 4.1 pIC50 = 4.1 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 295 4 1 5 2.2 Cc1noc(NS(=O)(=O)c2ccc(N(C)C)cc2)c1C 10.1021/jm00004a012
44293685 201890 0 None None None Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 521 10 2 8 3.9 CCOc1ccc2c(c1)[C@@H](c1cccc(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL300000 201890 0 None None None Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 521 10 2 8 3.9 CCOc1ccc2c(c1)[C@@H](c1cccc(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
10576377 26279 0 None None None Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 471 6 2 7 3.9 COc1cccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1021/jm9608366
CHEMBL1183291 26279 0 None None None Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 471 6 2 7 3.9 COc1cccc(NC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1021/jm9608366
44384715 123130 0 None None None Human 7.1 pIC50 = 7.1 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 559 9 1 9 5.2 CC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL174607 123130 0 None None None Human 7.1 pIC50 = 7.1 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 559 9 1 9 5.2 CC#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
44265861 197521 0 None None None Rat 7.1 pIC50 = 7.1 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 481 11 1 6 5.1 CCCC(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL268433 197521 0 None None None Rat 7.1 pIC50 = 7.1 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 481 11 1 6 5.1 CCCC(CCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL433406 488590 0 None None None Human 6.1 pIC50 = 6.1 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 938 25 10 8 4.0 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)NC)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
2529 347569 76 None None None Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/0960-894X(96)00441-6
5344 347569 76 None None None Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL453 347569 76 None None None Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/0960-894X(96)00441-6
DB00263 347569 76 None None None Human 6.1 pIC50 = 6.1 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL308208 486459 0 None None None Pig 5.1 pIC50 = 5.1 Binding
Binding activity against Endothelin A receptor of Porcine aortic smooth muscle membranesBinding activity against Endothelin A receptor of Porcine aortic smooth muscle membranes
ChEMBL 568 5 6 6 -0.2 CC(C)[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm00089a028
CHEMBL341751 487052 0 None None None Pig 5.1 pIC50 = 5.1 Binding
The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.The compound was tested for binding inhibitory activity against Endothelin A receptor from porcine aortic smooth muscle membranes.
ChEMBL 568 5 6 6 -0.2 CC(C)[C@@H]1NC(=O)[C@@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCN2C1=O 10.1021/jm00021a021
10763577 122677 0 None None None Rat 6.1 pIC50 = 6.1 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 401 7 1 4 5.3 Cc1ccccc1C(Oc1cc(OCc2c(C)cccc2C)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL173054 122677 0 None None None Rat 6.1 pIC50 = 6.1 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 401 7 1 4 5.3 Cc1ccccc1C(Oc1cc(OCc2c(C)cccc2C)ccc1C#N)C(=O)O 10.1021/jm990378b
10916428 318178 0 None None None Rat 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 402 4 1 5 4.4 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)cc1 10.1021/jm031041j
CHEMBL417050 318178 0 None None None Rat 7.1 pIC50 = 7.1 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 402 4 1 5 4.4 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)cc1 10.1021/jm031041j
15289331 199763 0 None None None Human 7.1 pIC50 = 7.1 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 433 6 1 6 5.3 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3ccccc23)c1 10.1016/0960-894X(96)00232-6
CHEMBL283648 199763 0 None None None Human 7.1 pIC50 = 7.1 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 433 6 1 6 5.3 COc1cccc(Sc2c(C(=O)O)n(Cc3ccc4c(c3)OCO4)c3ccccc23)c1 10.1016/0960-894X(96)00232-6
10916428 318178 0 None None None Rat 7.1 pIC50 = 7.1 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 402 4 1 5 4.4 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)cc1 10.1021/jm010382z
CHEMBL417050 318178 0 None None None Rat 7.1 pIC50 = 7.1 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 402 4 1 5 4.4 COc1ccc(C2=C(C(=O)O)C(c3ccc4c(c3)OCO4)Oc3ccccc32)cc1 10.1021/jm010382z
9810400 198865 0 None None None Human 7.1 pIC50 = 7.1 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 710 14 2 12 5.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
CHEMBL276949 198865 0 None None None Human 7.1 pIC50 = 7.1 Binding
Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorInhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 710 14 2 12 5.6 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ncccn2)nc1OCCCNS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)01083-1
10338501 202153 1 None None None Rat 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00004a012
CHEMBL30199 202153 1 None None None Rat 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00004a012
10275056 221993 0 None None None Human 7.1 pIC50 = 7.1 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 440 6 1 5 5.2 CCCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(96)00496-9
CHEMBL329890 221993 0 None None None Human 7.1 pIC50 = 7.1 Binding
Compound was tested for binding affinity against Endothelin A receptorCompound was tested for binding affinity against Endothelin A receptor
ChEMBL 440 6 1 5 5.2 CCCc1ccc(-c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(96)00496-9
9998564 199681 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2cccc(S(=O)(=O)Nc3onc(C)c3C)c2c1 10.1021/jm00008a013
CHEMBL283175 199681 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2cccc(S(=O)(=O)Nc3onc(C)c3C)c2c1 10.1021/jm00008a013
9998564 199681 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2cccc(S(=O)(=O)Nc3onc(C)c3C)c2c1 10.1021/jm00004a012
CHEMBL283175 199681 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1ccc2cccc(S(=O)(=O)Nc3onc(C)c3C)c2c1 10.1021/jm00004a012
10602312 122441 0 None None None Rat 5.1 pIC50 = 5.1 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 531 11 5 5 4.5 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NCc2ccccc2)nc1C(=O)O 10.1021/jm950592+
CHEMBL172178 122441 0 None None None Rat 5.1 pIC50 = 5.1 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 531 11 5 5 4.5 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NCc2ccccc2)nc1C(=O)O 10.1021/jm950592+
10571971 332896 0 None None None Rat 6.1 pIC50 = 6.1 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 382 9 1 4 5.6 Cc1ccccc1C(CCC(=O)O)Oc1cccc(OCc2ccsc2)c1 10.1021/jm9707131
CHEMBL433209 332896 0 None None None Rat 6.1 pIC50 = 6.1 Binding
In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.
ChEMBL 382 9 1 4 5.6 Cc1ccccc1C(CCC(=O)O)Oc1cccc(OCc2ccsc2)c1 10.1021/jm9707131
137639474 312811 0 None None None Human 6.1 pIC50 = 6.1 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 607 10 2 9 5.4 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC4CCCC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL4072165 312811 0 None None None Human 6.1 pIC50 = 6.1 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 607 10 2 9 5.4 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(-c4nnn[nH]4)c3)c(=O)c3cc(OCC4CCCC4)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
10696788 349891 0 None None None Human 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against human Endothelin A receptor using radioligand binding assay.In vitro inhibitory activity against human Endothelin A receptor using radioligand binding assay.
ChEMBL 501 5 2 9 3.9 Cc1noc(NS(=O)(=O)c2ccsc2NC(=O)Oc2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
CHEMBL45872 349891 0 None None None Human 7.1 pIC50 = 7.1 Binding
In vitro inhibitory activity against human Endothelin A receptor using radioligand binding assay.In vitro inhibitory activity against human Endothelin A receptor using radioligand binding assay.
ChEMBL 501 5 2 9 3.9 Cc1noc(NS(=O)(=O)c2ccsc2NC(=O)Oc2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
10338501 202153 1 None None None Human 6.1 pIC50 = 6.1 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00029a001
CHEMBL30199 202153 1 None None None Human 6.1 pIC50 = 6.1 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00029a001
10475320 196836 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 387 5 2 5 3.8 Cc1noc(NS(=O)(=O)c2cccc3c(NC(=O)C(C)C)cccc23)c1C 10.1021/jm00008a013
CHEMBL26252 196836 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 387 5 2 5 3.8 Cc1noc(NS(=O)(=O)c2cccc3c(NC(=O)C(C)C)cccc23)c1C 10.1021/jm00008a013
10338501 202153 1 None None None Rat 6.1 pIC50 = 6.1 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
CHEMBL30199 202153 1 None None None Rat 6.1 pIC50 = 6.1 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 359 4 2 5 3.2 CC(=O)Nc1cccc2c(S(=O)(=O)Nc3onc(C)c3C)cccc12 10.1021/jm00008a013
56678452 126036 0 None None None Human 6.1 pIC50 = 6.1 Binding
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 9 3.6 CC[C@H](C)[C@H](NC(=O)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@H](C)CC)C(=O)CNC(=O)[C@H](N)Cc1c[nH]c2ccccc12 10.1021/jm970161m
CHEMBL1793928 126036 0 None None None Human 6.1 pIC50 = 6.1 Binding
Inhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cellsInhibition of binding to Endothelin A receptor of rabbit renal vascular smooth muscle cells
ChEMBL 937 26 9 9 3.6 CC[C@H](C)[C@H](NC(=O)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)C(c1ccccc1)c1ccccc1)[C@H](C)CC)C(=O)CNC(=O)[C@H](N)Cc1c[nH]c2ccccc12 10.1021/jm970161m
44311288 469113 0 None None None Human 6.1 pIC50 = 6.1 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 592 11 1 10 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)c1cccnc1 10.1016/S0960-894X(97)00400-9
CHEMBL70781 469113 0 None None None Human 6.1 pIC50 = 6.1 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 592 11 1 10 5.3 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)c1cccnc1 10.1016/S0960-894X(97)00400-9
14673588 18755 0 None None None Human 5.1 pIC50 = 5.1 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 342 6 1 4 5.0 CC(C)Oc1c(C(=O)O)sc2ccc(OCc3ccccc3)cc12 10.1016/0960-894X(96)00232-6
CHEMBL10143 18755 0 None None None Human 5.1 pIC50 = 5.1 Binding
Affinity for human endothelin A receptor expressed in Ltk cells.Affinity for human endothelin A receptor expressed in Ltk cells.
ChEMBL 342 6 1 4 5.0 CC(C)Oc1c(C(=O)O)sc2ccc(OCc3ccccc3)cc12 10.1016/0960-894X(96)00232-6
14673588 18755 0 None None None Human 5.1 pIC50 = 5.1 Binding
Compound was evaluated for binding affinity against human Endothelin A receptorCompound was evaluated for binding affinity against human Endothelin A receptor
ChEMBL 342 6 1 4 5.0 CC(C)Oc1c(C(=O)O)sc2ccc(OCc3ccccc3)cc12 10.1016/0960-894X(96)00170-9
CHEMBL10143 18755 0 None None None Human 5.1 pIC50 = 5.1 Binding
Compound was evaluated for binding affinity against human Endothelin A receptorCompound was evaluated for binding affinity against human Endothelin A receptor
ChEMBL 342 6 1 4 5.0 CC(C)Oc1c(C(=O)O)sc2ccc(OCc3ccccc3)cc12 10.1016/0960-894X(96)00170-9
10790183 473226 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 461 8 1 6 4.3 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CCOc2ccccc2)cc1 10.1021/jm9505369
CHEMBL8677 473226 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 461 8 1 6 4.3 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CCOc2ccccc2)cc1 10.1021/jm9505369
127026058 274651 0 None None None Human 6.1 pIC50 = 6.1 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 600 10 3 8 6.0 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3751899 274651 0 None None None Human 6.1 pIC50 = 6.1 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 600 10 3 8 6.0 CCCc1nc2c(C)cc(C(=O)Nc3ccccc3OC)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
10839533 201568 0 None None None Human 6.1 pIC50 = 6.1 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 513 5 2 9 2.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)NC(=O)c2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
CHEMBL297599 201568 0 None None None Human 6.1 pIC50 = 6.1 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 513 5 2 9 2.9 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)NC(=O)c2ccc3c(c2)OCO3)c1Br 10.1021/jm9700068
10839947 236150 0 None None None Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 530 9 2 6 5.0 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
CHEMBL339657 236150 0 None None None Human 7.1 pIC50 = 7.1 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 530 9 2 6 5.0 CCc1cccc(CC)c1NC(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm990170q
44320777 473190 0 None None None Rat 7.1 pIC50 = 7.1 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 550 10 2 8 4.7 COc1ccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c(OCC(=O)O)c1 10.1016/s0960-894x(00)00513-8
CHEMBL86505 473190 0 None None None Rat 7.1 pIC50 = 7.1 Binding
In vitro binding affinity to endothelin A receptor in rat heart ventriclesIn vitro binding affinity to endothelin A receptor in rat heart ventricles
ChEMBL 550 10 2 8 4.7 COc1ccc(Cn2nc(-c3ccccc3)c(Cc3cc4c(cc3Cl)OCO4)c2C(=O)O)c(OCC(=O)O)c1 10.1016/s0960-894x(00)00513-8
10415067 98646 0 None None None Pig 5.1 pIC50 = 5.1 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 546 8 2 6 5.0 O=C(O)C(Cc1c[nH]c2ccccc12)N(Cc1cc2c(cc1Cl)OCO2)C(=O)/C=C/c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00009-9
CHEMBL152713 98646 0 None None None Pig 5.1 pIC50 = 5.1 Binding
Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.Ability to bind with Endothelin A receptor competitively in the presence of (125 I) endothelin using receptor binding assay.
ChEMBL 546 8 2 6 5.0 O=C(O)C(Cc1c[nH]c2ccccc12)N(Cc1cc2c(cc1Cl)OCO2)C(=O)/C=C/c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00009-9
10449375 196129 0 None None None Rat 5.1 pIC50 = 5.1 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 331 4 1 5 3.0 Cc1cc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)on1 10.1021/jm00008a013
CHEMBL25854 196129 0 None None None Rat 5.1 pIC50 = 5.1 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 331 4 1 5 3.0 Cc1cc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)on1 10.1021/jm00008a013
CHEMBL289687 486377 0 None None None Human 5.1 pIC50 = 5.1 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 837 24 10 9 1.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
3811690 470257 1 None None None Human 5.1 pIC50 = 5.1 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1noc(NS(=O)(=O)c2ccc(Br)cc2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL80129 470257 1 None None None Human 5.1 pIC50 = 5.1 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 330 3 1 4 2.9 Cc1noc(NS(=O)(=O)c2ccc(Br)cc2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL289687 486377 0 None None None Human 5.1 pIC50 = 5.1 Binding
Inhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cellsInhibition of [125I]endothelin-1 [ET-1] binding to endothelin A receptor (ETA) of rabbit renal artery vascular smooth muscle cells
ChEMBL 837 24 10 9 1.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(95)00152-J
127035082 273948 0 None None None Human 6.1 pIC50 = 6.1 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 677 12 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3736262 273948 0 None None None Human 6.1 pIC50 = 6.1 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 677 12 2 8 7.4 CCCc1nc2c(C)cc(C(=O)NCc3cccc(OC)c3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
15411002 218158 0 None None None Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 563 9 1 10 4.2 CNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 10.1016/S0960-894X(97)00002-4
CHEMBL320183 218158 0 None None None Human 8.1 pIC50 = 8.1 Binding
Binding affinity for human Endothelin A receptor expressed in LtK- cellsBinding affinity for human Endothelin A receptor expressed in LtK- cells
ChEMBL 563 9 1 10 4.2 CNC(=O)OC1(c2ccc(OC)cc2)OC(=O)C(c2ccc3c(c2)OCO3)=C1Cc1cc(OC)c(OC)c(OC)c1 10.1016/S0960-894X(97)00002-4
44314661 203075 0 None None None Pig 8.1 pIC50 = 8.1 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 603 14 5 4 5.1 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CCCC)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL306977 203075 0 None None None Pig 8.1 pIC50 = 8.1 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 603 14 5 4 5.1 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(CCCC)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
10646514 122118 0 None None None Rat 8.1 pIC50 = 8.1 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 434 7 1 6 5.1 N#Cc1ccc(OCc2ccc3ncoc3c2)cc1OC(C(=O)O)c1ccccc1Cl 10.1021/jm990378b
CHEMBL170681 122118 0 None None None Rat 8.1 pIC50 = 8.1 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 434 7 1 6 5.1 N#Cc1ccc(OCc2ccc3ncoc3c2)cc1OC(C(=O)O)c1ccccc1Cl 10.1021/jm990378b
10693270 122845 1 None None None Rat 8.1 pIC50 = 8.1 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
9931773 122845 1 None None None Rat 8.1 pIC50 = 8.1 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL173792 122845 1 None None None Rat 8.1 pIC50 = 8.1 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL2110231 122845 1 None None None Rat 8.1 pIC50 = 8.1 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 417 7 1 6 4.4 Cc1ccccc1C(Oc1cc(OCc2ccc3c(c2)OCO3)ccc1C#N)C(=O)O 10.1021/jm990378b
10547407 123009 0 None None None Rat 8.1 pIC50 = 8.1 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 374 7 1 5 4.0 Cc1ccccc1C(Oc1cc(OCc2ccncc2)ccc1C#N)C(=O)O 10.1021/jm990378b
10619391 123009 0 None None None Rat 8.1 pIC50 = 8.1 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 374 7 1 5 4.0 Cc1ccccc1C(Oc1cc(OCc2ccncc2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL174092 123009 0 None None None Rat 8.1 pIC50 = 8.1 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 374 7 1 5 4.0 Cc1ccccc1C(Oc1cc(OCc2ccncc2)ccc1C#N)C(=O)O 10.1021/jm990378b
CHEMBL2110232 123009 0 None None None Rat 8.1 pIC50 = 8.1 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 374 7 1 5 4.0 Cc1ccccc1C(Oc1cc(OCc2ccncc2)ccc1C#N)C(=O)O 10.1021/jm990378b
44311285 202385 0 None None None Human 8.1 pIC50 = 8.1 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 635 13 2 10 6.4 CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(Oc2ccccc2OC)c(OCCOC(=O)Nc2ccccn2)n1 10.1016/S0960-894X(97)00400-9
CHEMBL303428 202385 0 None None None Human 8.1 pIC50 = 8.1 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 635 13 2 10 6.4 CCCc1nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c(Oc2ccccc2OC)c(OCCOC(=O)Nc2ccccn2)n1 10.1016/S0960-894X(97)00400-9
10992620 461706 0 None None None Rat 8.0 pIC50 = 8.0 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 384 5 1 6 3.8 COC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
CHEMBL65070 461706 0 None None None Rat 8.0 pIC50 = 8.0 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 384 5 1 6 3.8 COC1=C(C(=O)O)C(c2ccc3c(c2)OCO3)Oc2ccc(OC(C)C)cc21 10.1021/jm010382z
44314646 469905 0 None None None Pig 8.0 pIC50 = 8.0 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 633 13 5 4 4.7 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCCC1)C(=O)O 10.1021/jm9600914
CHEMBL77033 469905 0 None None None Pig 8.0 pIC50 = 8.0 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 633 13 5 4 4.7 CCCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1CCCCCC1)C(=O)O 10.1021/jm9600914
44314889 213465 0 None None None Pig 8.0 pIC50 = 8.0 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 633 12 5 4 4.7 CCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL308815 213465 0 None None None Pig 8.0 pIC50 = 8.0 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 633 12 5 4 4.7 CCCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
44314620 203194 0 None None None Pig 8.0 pIC50 = 8.0 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 587 12 5 4 4.4 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
CHEMBL307903 203194 0 None None None Pig 8.0 pIC50 = 8.0 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 587 12 5 4 4.4 CCCCC(NC(=O)[C@@H](Cc1c(Cl)[nH]c2ccccc12)NC(=O)C(NC(=O)N1[C@@H](C)CCC[C@H]1C)C1CC1)C(=O)O 10.1021/jm9600914
23445404 201053 0 None None None Human 8.0 pIC50 = 8.0 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 456 5 1 7 4.1 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00367-3
CHEMBL293877 201053 0 None None None Human 8.0 pIC50 = 8.0 Binding
In vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptorIn vitro binding affinity in a radioligand binding experiment by competition with [125I]-labeled endothelin-1 for ETA receptor
ChEMBL 456 5 1 7 4.1 Cc1ccc(OC(=O)c2sccc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00367-3
10119105 201570 0 None None None Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 526 7 2 9 3.1 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CC(=O)N(C)C)OCO3)c1Cl 10.1021/jm9608366
CHEMBL297618 201570 0 None None None Human 8.0 pIC50 = 8.0 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 526 7 2 9 3.1 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2cc3c(cc2CC(=O)N(C)C)OCO3)c1Cl 10.1021/jm9608366
10650062 123211 0 None None None Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 537 10 4 6 4.8 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
CHEMBL175228 123211 0 None None None Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity was evaluated against human Endothelin A receptorInhibitory activity was evaluated against human Endothelin A receptor
ChEMBL 537 10 4 6 4.8 Cc1[nH]c([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)OC(=O)NC2CCCCC2)nc1C(=O)O 10.1021/jm9505932
155517241 334717 0 None None None Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 522 14 2 11 2.9 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
CHEMBL4444355 334717 0 None None None Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 522 14 2 11 2.9 CCCNS(=O)(=O)Nc1ncnc(OCCOc2ncc(SC)cn2)c1Oc1ccccc1OC 10.1016/j.bmcl.2016.06.014
10129267 163117 0 None None None Human 8.0 pIC50 = 8.0 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 617 13 1 12 3.9 CCCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
CHEMBL2163714 163117 0 None None None Human 8.0 pIC50 = 8.0 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 617 13 1 12 3.9 CCCS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
44314723 469866 0 None None None Pig 8.0 pIC50 = 8.0 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 583 13 5 4 4.7 CCCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL76735 469866 0 None None None Pig 8.0 pIC50 = 8.0 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 583 13 5 4 4.7 CCCCC(NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
44314659 469983 0 None None None Pig 8.0 pIC50 = 8.0 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 631 12 5 4 4.5 C=CCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
CHEMBL77853 469983 0 None None None Pig 8.0 pIC50 = 8.0 Binding
Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.Binding affinity towards endothelin A receptor in porcine aortic smooth muscle membranes.
ChEMBL 631 12 5 4 4.5 C=CCC(NC(=O)[C@@H](Cc1c(Br)[nH]c2ccccc12)NC(=O)C(CC(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C(=O)O 10.1021/jm9600914
52949155 42271 0 None None None Human 8.0 pIC50 = 8 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 557 10 2 7 5.4 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC(C)C)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
CHEMBL1271640 42271 0 None None None Human 8.0 pIC50 = 8 Binding
Antagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assayAntagonist activity at ETA receptor (unknown origin) expressed in HEK293T cells measured after 30 mins by CCF4-AM dye based GeneBlazer FRET assay
ChEMBL 557 10 2 7 5.4 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OCC(C)C)ccc31)OCO2 10.1016/j.bmcl.2017.04.049
10814318 23457 0 None None None Rat 8.0 pIC50 = 8 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 472 14 1 5 4.7 C=CCCC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
CHEMBL110064 23457 0 None None None Rat 8.0 pIC50 = 8 Binding
Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)Binding affinity for endothelin A receptor by measuring its ability to displace [125I]ET1 from prolactin secreting rat pituitary cells(MMQ)
ChEMBL 472 14 1 5 4.7 C=CCCC[C@H]1[C@H](C(=O)O)[C@@H](c2ccc3c(c2)OCO3)CN1CC(=O)N(CCCC)CCCC 10.1021/jm980217s
52944083 42278 0 None None None Human 8.0 pIC50 = 8 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 557 10 2 7 5.5 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OC(C)CC)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
CHEMBL1271691 42278 0 None None None Human 8.0 pIC50 = 8 Binding
Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerDisplacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayer
ChEMBL 557 10 2 7 5.5 CCc1cc2c(cc1Cn1c(C(=O)O)c(Cc3cccc(C(=O)O)c3)c(=O)c3cc(OC(C)CC)ccc31)OCO2 10.1016/j.bmcl.2010.08.074
71456864 163121 0 None None None Human 8.0 pIC50 = 8 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 618 13 2 12 3.0 CCNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
CHEMBL2163718 163121 0 None None None Human 8.0 pIC50 = 8 Binding
Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysisDisplacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis
ChEMBL 618 13 2 12 3.0 CCNS(=O)(=O)Nc1nc(-c2ncccn2)nc(OCCOc2ncc(Br)cn2)c1Oc1ccccc1OC 10.1021/jm3009103
11734340 328679 0 None None None Pig 8.0 pIC50 = 8 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 552 10 1 10 4.6 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccncc2)nc1 10.1021/jm0102304
CHEMBL420501 328679 0 None None None Pig 8.0 pIC50 = 8 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 552 10 1 10 4.6 CSc1cnc(OCCOc2ncnc(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)c2-c2ccncc2)nc1 10.1021/jm0102304
10501279 198504 0 None None None Human 7.1 pIC50 = 7.1 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 402 6 1 5 4.1 COc1ccc(C2(O)OC(=O)C(c3cccc(OC)c3)=C2Cc2ccccc2)cc1 10.1021/jm9606507
CHEMBL274307 198504 0 None None None Human 7.1 pIC50 = 7.1 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 402 6 1 5 4.1 COc1ccc(C2(O)OC(=O)C(c3cccc(OC)c3)=C2Cc2ccccc2)cc1 10.1021/jm9606507
44371516 104220 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 469 7 1 6 5.6 CCOc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc(OC)cc2)c2oc3ccccc3c21 10.1016/s0960-894x(99)00040-2
CHEMBL157827 104220 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Ability to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranesAbility to displace [125I]endothelin-1 from endothelin A receptor in rat aorta membranes
ChEMBL 469 7 1 6 5.6 CCOc1ccccc1Cn1c(=O)c(C(=O)O)c(-c2ccc(OC)cc2)c2oc3ccccc3c21 10.1016/s0960-894x(99)00040-2
CHEMBL279259 486343 0 None None None Mouse 6.1 pIC50 = 6.1 Binding
Binding affinity for Endothelin A receptor was determined in murine 3T3 cellsBinding affinity for Endothelin A receptor was determined in murine 3T3 cells
ChEMBL 848 25 10 9 1.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](N)CCCNC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(00)80326-1
11794876 474091 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 393 7 1 4 4.9 O=C(O)/C(=C/c1cc(OCc2ccccc2)ccc1[N+](=O)[O-])c1ccccc1F 10.1021/jm970847e
CHEMBL92446 474091 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.Concentration required to inhibit 50% Et-1 binding to endothelin A receptor in rat A-10 cells.
ChEMBL 393 7 1 4 4.9 O=C(O)/C(=C/c1cc(OCc2ccccc2)ccc1[N+](=O)[O-])c1ccccc1F 10.1021/jm970847e
44213651 18647 0 None None None Human 6.1 pIC50 = 6.1 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 343 3 1 4 4.2 OCC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
CHEMBL100795 18647 0 None None None Human 6.1 pIC50 = 6.1 Binding
Inhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cellsInhibition of binding of [125I]ET1 to cloned human Endothelin A receptor expressed in LtK- cells
ChEMBL 343 3 1 4 4.2 OCC(c1ccc2c(c1)OCO2)c1c2ccccc2nc2ccccc12 10.1016/S0960-894X(96)00551-3
10742024 197267 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 446 7 1 6 3.9 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CCc2ccccn2)cc1 10.1021/jm9505369
CHEMBL266143 197267 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibitory activity against the Endothelin A receptor of rat MMQ cellsInhibitory activity against the Endothelin A receptor of rat MMQ cells
ChEMBL 446 7 1 6 3.9 COc1ccc([C@@H]2[C@@H](C(=O)O)[C@H](c3ccc4c(c3)OCO4)CN2CCc2ccccn2)cc1 10.1021/jm9505369
10841134 123215 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 589 10 4 6 5.3 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC23CC4CC(CC(C4)C2)C3)nc1C(=O)O 10.1021/jm950592+
CHEMBL175277 123215 0 None None None Rat 6.1 pIC50 = 6.1 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 589 10 4 6 5.3 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC23CC4CC(CC(C4)C2)C3)nc1C(=O)O 10.1021/jm950592+
44311321 469114 0 None None None Human 6.1 pIC50 = 6.1 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 607 11 2 10 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)Nc1cccnc1 10.1016/S0960-894X(97)00400-9
CHEMBL70788 469114 0 None None None Human 6.1 pIC50 = 6.1 Binding
Receptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cellsReceptor binding affinity was determined against [125I]ET1 with recombinant human ETA receptor, expressed in baculovirus-infected Sf9 cells
ChEMBL 607 11 2 10 5.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(C)nc1OCCOC(=O)Nc1cccnc1 10.1016/S0960-894X(97)00400-9
2529 347569 76 None None None Rat 5.1 pIC50 = 5.1 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/s0960-894x(00)00366-8
5344 347569 76 None None None Rat 5.1 pIC50 = 5.1 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/s0960-894x(00)00366-8
CHEMBL453 347569 76 None None None Rat 5.1 pIC50 = 5.1 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/s0960-894x(00)00366-8
DB00263 347569 76 None None None Rat 5.1 pIC50 = 5.1 Binding
Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorDisplacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptor
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 10.1016/s0960-894x(00)00366-8
10015852 199644 1 None None None Rat 5.1 pIC50 = 5.1 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 268 3 2 5 1.8 Cc1noc(NS(=O)(=O)c2ccc(O)cc2)c1C 10.1021/jm00004a012
CHEMBL282961 199644 1 None None None Rat 5.1 pIC50 = 5.1 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 268 3 2 5 1.8 Cc1noc(NS(=O)(=O)c2ccc(O)cc2)c1C 10.1021/jm00004a012
22616255 470368 6 None None None Human 4.1 pIC50 = 4.1 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 297 4 1 6 2.0 Cc1noc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL80945 470368 6 None None None Human 4.1 pIC50 = 4.1 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 297 4 1 6 2.0 Cc1noc(NS(=O)(=O)c2ccc([N+](=O)[O-])cc2)c1C 10.1016/0960-894X(96)00441-6
23445333 255750 0 None None None Human 7.0 pIC50 = 7.0 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 484 6 1 7 4.4 Cc1cc2c(cc1CCc1ccsc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00133-9
CHEMBL366378 255750 0 None None None Human 7.0 pIC50 = 7.0 Binding
Inhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayInhibitory of human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 484 6 1 7 4.4 Cc1cc2c(cc1CCc1ccsc1S(=O)(=O)Nc1onc(C)c1Br)OCO2 10.1016/S0960-894X(97)00133-9
CHEMBL313984 486534 0 None None None Human 6.0 pIC50 = 6.0 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 881 24 9 8 2.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
CHEMBL317099 486608 0 None None None Human 6.0 pIC50 = 6.0 Binding
Binding affinity against endothelin A receptor from rabbit renal vascular smooth musclesBinding affinity against endothelin A receptor from rabbit renal vascular smooth muscles
ChEMBL 881 24 9 8 2.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00015a003
10792636 333192 0 None None None Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 544 10 2 6 5.4 CCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(CC)cccc2CC)cc1 10.1021/jm990170q
CHEMBL435385 333192 0 None None None Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 544 10 2 6 5.4 CCOc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(CC)cccc2CC)cc1 10.1021/jm990170q
CHEMBL315658 486602 0 None None None Human 5.0 pIC50 = 5.0 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 734 20 8 7 2.0 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00070a001
127026042 274662 0 None None None Human 5.0 pIC50 = 5.0 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 620 11 3 9 3.8 CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL3751986 274662 0 None None None Human 5.0 pIC50 = 5.0 Binding
Displacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranesDisplacement of 125I-labelled endothelin-1 from human ETA receptor expressed in CHOK1 cell membranes
ChEMBL 620 11 3 9 3.8 CCCc1nc2c(C)cc(C(=O)NCCN3CCN(C)CC3)cc2n1Cc1ccc(-c2ccccc2C(=O)Nc2nnn[nH]2)cc1 10.1039/C5MD00169B
CHEMBL315658 486602 0 None None None Human 5.0 pIC50 = 5.0 Binding
Displacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cellsDisplacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cells
ChEMBL 734 20 8 7 2.0 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81215-4
11145367 24319 0 None None None Pig 7.0 pIC50 = 7.0 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 487 10 1 8 4.4 COCCOc1ncnc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1cccc(OC)c1 10.1021/jm0102304
CHEMBL114985 24319 0 None None None Pig 7.0 pIC50 = 7.0 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 487 10 1 8 4.4 COCCOc1ncnc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1cccc(OC)c1 10.1021/jm0102304
10745418 233019 1 None None None Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 9 2 6 6.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(C(C)C)cccc2C(C)C)cc1 10.1021/jm990170q
CHEMBL332627 233019 1 None None None Human 6.0 pIC50 = 6.0 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 9 2 6 6.2 COc1ccc([C@H]2[C@H](C(=O)O)[C@@H](c3ccc4c(c3)OCO4)CN2CC(=O)Nc2c(C(C)C)cccc2C(C)C)cc1 10.1021/jm990170q
10015852 199644 1 None None None Human 5.0 pIC50 = 5.0 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 268 3 2 5 1.8 Cc1noc(NS(=O)(=O)c2ccc(O)cc2)c1C 10.1021/jm00029a001
CHEMBL282961 199644 1 None None None Human 5.0 pIC50 = 5.0 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 268 3 2 5 1.8 Cc1noc(NS(=O)(=O)c2ccc(O)cc2)c1C 10.1021/jm00029a001
10015852 199644 1 None None None Rat 5.0 pIC50 = 5.0 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 268 3 2 5 1.8 Cc1noc(NS(=O)(=O)c2ccc(O)cc2)c1C 10.1021/jm00008a013
CHEMBL282961 199644 1 None None None Rat 5.0 pIC50 = 5.0 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 268 3 2 5 1.8 Cc1noc(NS(=O)(=O)c2ccc(O)cc2)c1C 10.1021/jm00008a013
11813885 332559 0 None None None Pig 7.0 pIC50 = 7.0 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 579 12 1 10 5.3 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCCOc2ncc(C)cn2)c1 10.1021/jm0102304
CHEMBL430515 332559 0 None None None Pig 7.0 pIC50 = 7.0 Binding
In vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cellsIn vitro inhibition of [125I]ET1 binding to Endothelin A receptor in porcine aortic membrane from endothelial cells
ChEMBL 579 12 1 10 5.3 COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)ncnc2OCCCOc2ncc(C)cn2)c1 10.1021/jm0102304
CHEMBL313056 486528 0 None None None Human 6.0 pIC50 = 6.0 Binding
Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsBinding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cells
ChEMBL 750 21 9 8 0.9 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00070a001
10576217 24064 0 None None None Rat 6.0 pIC50 = 6.0 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 467 12 1 5 4.4 CCCCN(CCCC)C(=O)CN1C[C@H](c2cccnc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL113494 24064 0 None None None Rat 6.0 pIC50 = 6.0 Binding
Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.
ChEMBL 467 12 1 5 4.4 CCCCN(CCCC)C(=O)CN1C[C@H](c2cccnc2)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 10.1021/jm960077r
CHEMBL146155 484691 0 None None None Human 6.0 pIC50 = 6.0 Binding
Displacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cellsDisplacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cells
ChEMBL 881 24 9 8 2.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81215-4
11798109 26628 0 None None None Human 6.0 pIC50 = 6.0 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 457 7 2 7 4.2 COc1cccc(NCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1021/jm9608366
CHEMBL1185459 26628 0 None None None Human 6.0 pIC50 = 6.0 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 457 7 2 7 4.2 COc1cccc(NCc2sccc2S(=O)(=O)Nc2onc(C)c2Br)c1 10.1021/jm9608366
23445544 124135 0 None None None Human 6.0 pIC50 = 6.0 Binding
Tested for its activity in cloned human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayTested for its activity in cloned human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 438 5 1 5 5.1 Cc1ccc(/C=C/c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00133-9
CHEMBL176912 124135 0 None None None Human 6.0 pIC50 = 6.0 Binding
Tested for its activity in cloned human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assayTested for its activity in cloned human Endothelin A receptor by using I-ET-1 as radioligand in a competitive radioligand assay
ChEMBL 438 5 1 5 5.1 Cc1ccc(/C=C/c2ccsc2S(=O)(=O)Nc2onc(C)c2Br)cc1 10.1016/S0960-894X(97)00133-9
3887 4239 39 None None None Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 2 hrsDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 2 hrs
ChEMBL 573 10 3 3 5.9 Cc1cc(C)cc(c1)C(=O)N([C@@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)Cc1ccc(cc1)c1ccccc1)C 10.1021/acs.jmedchem.5b01781
5311192 4239 39 None None None Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 2 hrsDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 2 hrs
ChEMBL 573 10 3 3 5.9 Cc1cc(C)cc(c1)C(=O)N([C@@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)Cc1ccc(cc1)c1ccccc1)C 10.1021/acs.jmedchem.5b01781
CHEMBL72410 4239 39 None None None Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 2 hrsDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 2 hrs
ChEMBL 573 10 3 3 5.9 Cc1cc(C)cc(c1)C(=O)N([C@@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)Cc1ccc(cc1)c1ccccc1)C 10.1021/acs.jmedchem.5b01781
44386002 123066 0 None None None Human 7.0 pIC50 = 7.0 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 503 9 1 9 3.9 C#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL174326 123066 0 None None None Human 7.0 pIC50 = 7.0 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 503 9 1 9 3.9 C#CCOc1nc(-c2ccncc2)nc(NS(=O)(=O)c2ccc(C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
11005242 467962 0 None None None Rat 7.0 pIC50 = 7.0 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 8 1 6 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)cc1)O2 10.1021/jm010382z
CHEMBL62719 467962 0 None None None Rat 7.0 pIC50 = 7.0 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 474 8 1 6 5.6 CCCCOc1ccc2c(c1)C(c1ccc3c(c1)OCO3)=C(C(=O)O)C(c1ccc(OC)cc1)O2 10.1021/jm010382z
44293682 368974 0 None None None Human 7.0 pIC50 = 7.0 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 447 7 1 6 4.4 CCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL48652 368974 0 None None None Human 7.0 pIC50 = 7.0 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 447 7 1 6 4.4 CCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
10553165 24044 0 None None None Human 6.0 pIC50 = 6.0 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 492 7 1 6 5.4 O=C1OC(O)(c2ccc(OCc3ccccc3)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
CHEMBL11341 24044 0 None None None Human 6.0 pIC50 = 6.0 Binding
Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsBinding affinity against human cloned endothelin A receptor expressed in LTK-cells
ChEMBL 492 7 1 6 5.4 O=C1OC(O)(c2ccc(OCc3ccccc3)cc2)C(Cc2ccccc2)=C1c1ccc2c(c1)OCO2 10.1021/jm9606507
CHEMBL414917 488371 0 None None None Human 5.0 pIC50 = 5.0 Binding
Binding affinity in LtK cells stably transfected with human endothelin A (ETA) receptorBinding affinity in LtK cells stably transfected with human endothelin A (ETA) receptor
ChEMBL 1040 22 11 10 3.5 NC(=O)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)C1c2ccccc2CCc2ccccc21)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/0960-894X(95)00084-7
CHEMBL289687 486377 0 None None None Human 5.0 pIC50 = 5.0 Binding
Displacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cellsDisplacement of [125I]-ET-1 from Endothelin A receptor of rabbit renal artery vascular smooth muscle cells
ChEMBL 837 24 10 9 1.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81215-4
CHEMBL289687 486377 0 None None None Human 5.0 pIC50 = 5.0 Binding
Inhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cellsInhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cells
ChEMBL 837 24 10 9 1.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]cn1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00095a029
127035085 273874 0 None None None Human 6.0 pIC50 = 6.0 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 661 12 2 7 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
CHEMBL3735574 273874 0 None None None Human 6.0 pIC50 = 6.0 Binding
Displacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysisDisplacement of 125I-labeled endothelin 1 from human ETA receptor expressed in CHO-K1 cells incubated for 4 hrs by gamma counting analysis
ChEMBL 661 12 2 7 7.4 CCCc1nc2c(C)cc(C(=O)NCCc3ccccc3)cc2n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1039/C4MD00499J
44293741 370218 0 None None None Rat 7.0 pIC50 = 7.0 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 447 7 1 6 4.4 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1021/jm031041j
CHEMBL49040 370218 0 None None None Rat 7.0 pIC50 = 7.0 Binding
Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.
ChEMBL 447 7 1 6 4.4 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1021/jm031041j
44293868 201708 0 None None None Human 7.0 pIC50 = 7.0 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 551 11 2 9 3.9 CCOc1ccc2c(c1)[C@H](c1ccc(OC)c(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL298664 201708 0 None None None Human 7.0 pIC50 = 7.0 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 551 11 2 9 3.9 CCOc1ccc2c(c1)[C@H](c1ccc(OC)c(OC)c1OCC(=O)O)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
44293741 370218 0 None None None Human 7.0 pIC50 = 7.0 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 447 7 1 6 4.4 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL49040 370218 0 None None None Human 7.0 pIC50 = 7.0 Binding
In vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptorIn vitro inhibition of [125I]ET1 binding to CHO cells expressing recombinant human Endothelin A receptor
ChEMBL 447 7 1 6 4.4 CCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1)N(CC(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
44384766 122443 0 None None None Human 7.0 pIC50 = 7.0 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 532 10 1 10 4.1 C#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL172184 122443 0 None None None Human 7.0 pIC50 = 7.0 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 532 10 1 10 4.1 C#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)C)cn2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
44385940 258568 0 None None None Rat 6.0 pIC50 = 6.0 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCC(C)C2)nc1C(=O)O 10.1021/jm950592+
CHEMBL368255 258568 0 None None None Rat 6.0 pIC50 = 6.0 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 551 10 4 6 4.9 Cc1oc([C@@H](Cc2cn(C)c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)NC2CCCC(C)C2)nc1C(=O)O 10.1021/jm950592+
44386421 123501 0 None None None Rat 5.0 pIC50 = 5.0 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 537 10 4 5 4.5 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1CC(=O)O 10.1021/jm950592+
CHEMBL176093 123501 0 None None None Rat 5.0 pIC50 = 5.0 Binding
Inhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenatesInhibitory activity was evaluated against ET- A Binding to Endothelin A receptor in MMQ cell homogenates
ChEMBL 537 10 4 5 4.5 Cc1oc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)N2CCCCCC2)nc1CC(=O)O 10.1021/jm950592+
9807456 123240 0 None None None Human 7.0 pIC50 = 7.0 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 545 9 1 9 4.8 C#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
CHEMBL175435 123240 0 None None None Human 7.0 pIC50 = 7.0 Binding
In vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorIn vitro inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptor
ChEMBL 545 9 1 9 4.8 C#CCOc1nc(-c2ncccn2)nc(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)c1Oc1ccccc1OC 10.1016/s0960-894x(02)01084-3
10195727 468896 0 None None None Rat 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 487 7 1 8 5.6 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2nsnc2c1 10.1016/s0960-894x(97)10151-2
CHEMBL69150 468896 0 None None None Rat 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptorInhibition of [125I]ET1 binding to rat aorta membrane Endothelin A receptor
ChEMBL 487 7 1 8 5.6 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2nsnc2c1 10.1016/s0960-894x(97)10151-2
10195727 468896 0 None None None Human 7.0 pIC50 = 7.0 Binding
Potency at Endothelin A receptor was determinedPotency at Endothelin A receptor was determined
ChEMBL 487 7 1 8 5.6 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2nsnc2c1 10.1021/jm0300429
CHEMBL69150 468896 0 None None None Human 7.0 pIC50 = 7.0 Binding
Potency at Endothelin A receptor was determinedPotency at Endothelin A receptor was determined
ChEMBL 487 7 1 8 5.6 CCCOc1ccc2c(c1)c(-c1ccc3c(c1)OCO3)c(C(=O)O)n2Cc1ccc2nsnc2c1 10.1021/jm0300429
44279360 216255 0 None None None Pig 6.0 pIC50 = 6.0 Binding
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 498 13 5 4 2.9 CC(C)C[C@H](NC(=O)CC1CCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
CHEMBL31426 216255 0 None None None Pig 6.0 pIC50 = 6.0 Binding
Binding affinity against ETA receptor in porcine aortic smooth muscle membraneBinding affinity against ETA receptor in porcine aortic smooth muscle membrane
ChEMBL 498 13 5 4 2.9 CC(C)C[C@H](NC(=O)CC1CCCC1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCC(=O)O 10.1016/0960-894X(95)00221-E
11048815 202399 0 None None None Rat 6.0 pIC50 = 6.0 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 7 1 6 5.2 CCCOc1ccc2c(c1)OC(c1ccc3c(c1)OCO3)C(C(=O)O)=C2c1ccc(OC)cc1 10.1021/jm010382z
CHEMBL303531 202399 0 None None None Rat 6.0 pIC50 = 6.0 Binding
Binding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cellsBinding affinity for endothelin A receptor by inhibition of [125I]ET1 binding in rat aorta smooth muscle cells
ChEMBL 460 7 1 6 5.2 CCCOc1ccc2c(c1)OC(c1ccc3c(c1)OCO3)C(C(=O)O)=C2c1ccc(OC)cc1 10.1021/jm010382z
10625738 334068 0 None None None Human 6.0 pIC50 = 6.0 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 517 6 2 6 5.5 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(-c3ccccc3)cc2)c1Br 10.1021/jm9608366
CHEMBL44321 334068 0 None None None Human 6.0 pIC50 = 6.0 Binding
In vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assayIn vitro inhibition of endothelin binding to human Endothelin A receptor using [125I]-labeled ET-1 competition assay
ChEMBL 517 6 2 6 5.5 Cc1noc(NS(=O)(=O)c2ccsc2C(=O)Nc2ccc(-c3ccccc3)cc2)c1Br 10.1021/jm9608366
9801094 122270 0 None None None Rat 7.0 pIC50 = 7.0 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 399 7 1 5 5.1 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1cccc(Cl)c1 10.1021/jm990378b
CHEMBL171446 122270 0 None None None Rat 7.0 pIC50 = 7.0 Binding
In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.In vitro ability to antagonise the binding of [125I]ET1 to the rat aortic A10 cell membrane endothelin A receptor.
ChEMBL 399 7 1 5 5.1 N#Cc1ccc(OCc2ccsc2)cc1OC(C(=O)O)c1cccc(Cl)c1 10.1021/jm990378b
CHEMBL359235 487189 0 None None None Mouse 7.0 pIC50 = 7.0 Binding
Inhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cellsInhibition of [125I]ET1 binding to Endothelin A receptor of murine 3T3 cells
ChEMBL 881 24 9 8 2.8 CC[C@@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@H](C)CC 10.1016/S0960-894X(01)81219-1
44316686 213249 0 None None None Human 6.0 pIC50 = 6.0 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 286 3 1 4 2.7 Cc1noc(NS(=O)(=O)c2ccccc2Cl)c1C 10.1016/0960-894X(96)00441-6
CHEMBL308521 213249 0 None None None Human 6.0 pIC50 = 6.0 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 286 3 1 4 2.7 Cc1noc(NS(=O)(=O)c2ccccc2Cl)c1C 10.1016/0960-894X(96)00441-6
10021240 195862 0 None None None Human 5.0 pIC50 = 5.0 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 357 6 2 5 3.7 Cc1noc(NS(=O)(=O)c2ccc(NCc3ccccc3)cc2)c1C 10.1021/jm00029a001
CHEMBL25730 195862 0 None None None Human 5.0 pIC50 = 5.0 Binding
Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsAbility to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cells
ChEMBL 357 6 2 5 3.7 Cc1noc(NS(=O)(=O)c2ccc(NCc3ccccc3)cc2)c1C 10.1021/jm00029a001
10021240 195862 0 None None None Rat 5.0 pIC50 = 5.0 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 357 6 2 5 3.7 Cc1noc(NS(=O)(=O)c2ccc(NCc3ccccc3)cc2)c1C 10.1021/jm00008a013
CHEMBL25730 195862 0 None None None Rat 5.0 pIC50 = 5.0 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 357 6 2 5 3.7 Cc1noc(NS(=O)(=O)c2ccc(NCc3ccccc3)cc2)c1C 10.1021/jm00008a013
10087192 199781 0 None None None Rat 5.0 pIC50 = 5.0 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3cccc(N)c3c2)c1C 10.1021/jm00008a013
CHEMBL283879 199781 0 None None None Rat 5.0 pIC50 = 5.0 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3cccc(N)c3c2)c1C 10.1021/jm00008a013
10087192 199781 0 None None None Rat 5.0 pIC50 = 5.0 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3cccc(N)c3c2)c1C 10.1021/jm00004a012
CHEMBL283879 199781 0 None None None Rat 5.0 pIC50 = 5.0 Binding
Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsInhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cells
ChEMBL 317 3 2 5 2.8 Cc1noc(NS(=O)(=O)c2ccc3cccc(N)c3c2)c1C 10.1021/jm00004a012
44276993 216513 0 None None None Rat 4.0 pIC50 = 4.0 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 362 5 1 3 3.8 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccccc3)c2=O)c1 10.1016/s0960-894x(00)00232-8
CHEMBL3144831 216513 0 None None None Rat 4.0 pIC50 = 4.0 Binding
In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assayIn vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay
ChEMBL 362 5 1 3 3.8 COc1cccc(Cn2[nH]c(C(F)(F)F)c(Cc3ccccc3)c2=O)c1 10.1016/s0960-894x(00)00232-8
3219 369899 38 None None None Human 5.0 pIC50 = 5.0 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 372 4 1 3 4.0 CC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc(S(C)(=O)=O)cc1 nan
5472495 369899 38 None None None Human 5.0 pIC50 = 5.0 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 372 4 1 3 4.0 CC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc(S(C)(=O)=O)cc1 nan
CHEMBL488025 369899 38 None None None Human 5.0 pIC50 = 5.0 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 372 4 1 3 4.0 CC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc(S(C)(=O)=O)cc1 nan
DB06246 369899 38 None None None Human 5.0 pIC50 = 5.0 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 372 4 1 3 4.0 CC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc(S(C)(=O)=O)cc1 nan
18617381 215372 0 None None None Human 6.0 pIC50 = 6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 300 3 1 4 3.1 Cc1noc(NS(=O)(=O)c2cccc(Cl)c2C)c1C 10.1016/0960-894X(96)00441-6
CHEMBL312551 215372 0 None None None Human 6.0 pIC50 = 6 Binding
Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 300 3 1 4 3.1 Cc1noc(NS(=O)(=O)c2cccc(Cl)c2C)c1C 10.1016/0960-894X(96)00441-6
15453170 214602 4 None None None Human 5.0 pIC50 = 5 Binding
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 328 4 1 4 3.8 Cc1noc(NS(=O)(=O)c2ccc(-c3ccccc3)cc2)c1C 10.1016/0960-894X(96)00441-6
CHEMBL311258 214602 4 None None None Human 5.0 pIC50 = 5 Binding
Binding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparationBinding affinity against human ETA receptor in TE 671(ATCC# HTB 139) cell membrane preparation
ChEMBL 328 4 1 4 3.8 Cc1noc(NS(=O)(=O)c2ccc(-c3ccccc3)cc2)c1C 10.1016/0960-894X(96)00441-6
1009 399 28 None None None Human 5.0 pIC50 = 5 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.1021/jm990170q
5310991 399 28 None None None Human 5.0 pIC50 = 5 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.1021/jm990170q
CHEMBL332794 399 28 None None None Human 5.0 pIC50 = 5 Binding
Binding affinity towards human Endothelin A receptor (hET -A)Binding affinity towards human Endothelin A receptor (hET -A)
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.1021/jm990170q
CHEMBL437472 484344 0 None None None Rat 9.8 pKd = 9.8 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL 2490 47 32 36 -4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL409577 488069 0 None None None Rat 9.5 pKd = 9.5 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)
ChEMBL 2410 47 32 33 -4.6 CCCC[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC1=O 10.1016/S0960-894X(01)81085-4
CHEMBL442316 488851 0 None None None Rat 9.2 pKd = 9.2 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)
ChEMBL 2446 45 31 35 -4.2 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
19095644 334281 0 None None None Rat 6.9 pKd = 6.9 Binding
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 549 10 2 8 5.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ccccc2)nc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL4438132 334281 0 None None None Rat 6.9 pKd = 6.9 Binding
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 549 10 2 8 5.4 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)nc(-c2ccccc2)nc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL438470 488718 0 None None None Rat 6.9 pKd = 6.9 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL 2356 40 30 33 -4.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](C)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL412467 488222 0 None None None Rat 5.9 pKd = 5.9 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)
ChEMBL 2462 46 32 36 -5.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
19735343 350024 0 None None None Rat 5.8 pKd = 5.8 Binding
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 473 7 2 6 4.0 O=S(=O)(Nc1ncnc(OCCO)c1-c1ccc(Cl)cc1)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL4590568 350024 0 None None None Rat 5.8 pKd = 5.8 Binding
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 473 7 2 6 4.0 O=S(=O)(Nc1ncnc(OCCO)c1-c1ccc(Cl)cc1)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2016.06.014
CHEMBL409577 488069 0 None None None Rat 7.8 pKd = 7.8 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)
ChEMBL 2410 47 32 33 -4.6 CCCC[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC(=O)[C@H](C)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC[C@H](C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC1=O 10.1016/S0960-894X(01)81085-4
CHEMBL386629 487695 0 None None None Rat 6.7 pKd = 6.7 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL 2432 44 31 35 -4.6 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
155519384 334972 0 None None None Rat 7.7 pKd = 7.7 Binding
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 674 12 1 13 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)c1ccccn1 10.1016/j.bmcl.2016.06.014
CHEMBL4448273 334972 0 None None None Rat 7.7 pKd = 7.7 Binding
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 674 12 1 13 4.1 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)C)cn2)nc(N2CCOCC2)nc1OCC#CCOC(=O)c1ccccn1 10.1016/j.bmcl.2016.06.014
CHEMBL438027 488690 0 None None None Rat 5.7 pKd = 5.7 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)
ChEMBL 2448 45 32 36 -5.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL263581 486090 0 None None None Rat 8.7 pKd = 8.7 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL 2448 45 32 36 -5.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/S0960-894X(01)81085-4
CHEMBL410001 488091 0 None None None Rat 5.5 pKd = 5.5 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL 2446 45 31 35 -4.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL412467 488222 0 None None None Rat 7.5 pKd = 7.5 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)
ChEMBL 2462 46 32 36 -5.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL409171 488049 0 None None None Rat 5.5 pKd = 5.5 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)
ChEMBL 2448 45 32 36 -5.7 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/S0960-894X(01)81085-4
104865 1454 67 None 30 2 Rat 7.4 pKd = 7.4 Binding
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
3494 1454 67 None 30 2 Rat 7.4 pKd = 7.4 Binding
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
392 1454 67 None 30 2 Rat 7.4 pKd = 7.4 Binding
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
CHEMBL957 1454 67 None 30 2 Rat 7.4 pKd = 7.4 Binding
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
DB00559 1454 67 None 30 2 Rat 7.4 pKd = 7.4 Binding
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/j.bmcl.2016.06.014
10395582 40849 0 None None None Rat 5.4 pKd = 5.4 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL 806 8 6 13 3.2 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)Nc4ccccc4)C(C)(C)C)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C 10.1016/S0960-894X(01)81085-4
CHEMBL125377 40849 0 None None None Rat 5.4 pKd = 5.4 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL 806 8 6 13 3.2 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)Nc4ccccc4)C(C)(C)C)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C 10.1016/S0960-894X(01)81085-4
CHEMBL414286 488332 0 None None None Rat 6.4 pKd = 6.4 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)
ChEMBL 2474 46 31 35 -3.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](C)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL409578 488070 0 None None None Rat 5.3 pKd = 5.3 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL 2532 48 32 36 -4.5 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](NC(C)=O)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL412346 488213 0 None None None Rat 7.3 pKd = 7.3 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL 2424 45 31 35 -4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL438027 488690 0 None None None Rat 8.2 pKd = 8.2 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)
ChEMBL 2448 45 32 36 -5.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL268318 486252 0 None None None Rat 6.2 pKd = 6.2 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL 2414 45 32 36 -5.9 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](C)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL442316 488851 0 None None None Rat 7.1 pKd = 7.1 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 2)
ChEMBL 2446 45 31 35 -4.2 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL414286 488332 0 None None None Rat 8.0 pKd = 8.0 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)
ChEMBL 2474 46 31 35 -3.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](C)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/S0960-894X(01)81085-4
CHEMBL407887 487993 0 None None None Rat 6.0 pKd = 6.0 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligandBinding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand
ChEMBL 2406 43 32 36 -6.8 CSCC[C@@H]1NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC1=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)O)CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N2 10.1016/S0960-894X(01)81085-4
10983585 347375 0 None None None Rat 6.0 pKd = 6.0 Binding
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 473 9 2 8 3.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL4525321 347375 0 None None None Rat 6.0 pKd = 6.0 Binding
Antagonist activity at rat aortic ring ETA receptor in presence of ET1Antagonist activity at rat aortic ring ETA receptor in presence of ET1
ChEMBL 473 9 2 8 3.7 COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C(C)(C)C)cc2)ncnc1OCCO 10.1016/j.bmcl.2016.06.014
CHEMBL409171 488049 0 None None None Rat 7.0 pKd = 7.0 Binding
Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)Binding affinity towards Endothelin A receptor in A10 rat thoracic aorta smooth muscle cells using [125I]ET1 as radioligand (Exp 1)
ChEMBL 2448 45 32 36 -5.7 CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@H](C(C)C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1016/S0960-894X(01)81085-4
44277840 198539 0 None 81283 2 Human 11.0 pKi = 11 Binding
Antagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition constantAntagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition constant
ChEMBL 522 7 1 7 5.8 Cc1onc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2N(C)C(=O)CC(C)(C)C)c1C 10.1016/j.ejmech.2022.114700
CHEMBL274489 198539 0 None 81283 2 Human 11.0 pKi = 11 Binding
Antagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition constantAntagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition constant
ChEMBL 522 7 1 7 5.8 Cc1onc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2N(C)C(=O)CC(C)(C)C)c1C 10.1016/j.ejmech.2022.114700
44277840 198539 0 None 81283 2 Human 11.0 pKi = 11 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 522 7 1 7 5.8 Cc1onc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2N(C)C(=O)CC(C)(C)C)c1C 10.1021/jm020289q
CHEMBL274489 198539 0 None 81283 2 Human 11.0 pKi = 11 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 522 7 1 7 5.8 Cc1onc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2N(C)C(=O)CC(C)(C)C)c1C 10.1021/jm020289q
11071765 333812 0 None 8709 2 Human 11.0 pKi = 11 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 556 9 1 7 5.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)Cc2ccccc2)c1C 10.1021/jm020289q
CHEMBL440780 333812 0 None 8709 2 Human 11.0 pKi = 11 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 556 9 1 7 5.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)Cc2ccccc2)c1C 10.1021/jm020289q
44275660 198928 0 None None None Human 11.0 pKi = 11 Binding
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 522 8 2 7 5.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CNC(=O)CC(C)(C)C)c1C 10.1021/jm030480f
CHEMBL277447 198928 0 None None None Human 11.0 pKi = 11 Binding
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 522 8 2 7 5.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CNC(=O)CC(C)(C)C)c1C 10.1021/jm030480f
9852318 23918 9 None 2691 2 Human 10.8 pKi = 10.8 Binding
Ability to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cellsAbility to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cells
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm000538f
CHEMBL112624 23918 9 None 2691 2 Human 10.8 pKi = 10.8 Binding
Ability to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cellsAbility to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cells
ChEMBL 613 11 2 9 4.5 Cc1ccc(-c2c(NS(=O)(=O)c3ccc(C(C)(C)CO)cc3)ncnc2OCCOc2ncc(Br)cn2)cc1 10.1021/jm000538f
10119517 199452 0 None 169824 2 Human 10.7 pKi = 10.7 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 536 8 1 7 5.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CC(C)(C)C)c1C 10.1021/jm020289q
CHEMBL281659 199452 0 None 169824 2 Human 10.7 pKi = 10.7 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 536 8 1 7 5.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CC(C)(C)C)c1C 10.1021/jm020289q
11124425 200051 0 None 75857 2 Human 10.7 pKi = 10.7 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 543 7 1 8 5.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cn2ccc(C(F)(F)F)n2)c1C 10.1021/jm020289q
CHEMBL285832 200051 0 None 75857 2 Human 10.7 pKi = 10.7 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 543 7 1 8 5.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cn2ccc(C(F)(F)F)n2)c1C 10.1021/jm020289q
10918301 201619 0 None 7585 2 Human 10.7 pKi = 10.7 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 514 8 1 7 6.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)c2ccccc2)c1C 10.1021/jm020289q
CHEMBL29793 201619 0 None 7585 2 Human 10.7 pKi = 10.7 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 514 8 1 7 6.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)c2ccccc2)c1C 10.1021/jm020289q
CHEMBL437472 484344 0 None -4 5 Human 10.6 pKi = 10.6 Binding
Binding affinity to human ETA receptor by radioligand displacement assayBinding affinity to human ETA receptor by radioligand displacement assay
ChEMBL 2490 47 32 36 -4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/j.ejmech.2013.01.044
11731054 199052 0 None 21379 2 Human 10.5 pKi = 10.5 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 522 7 1 7 5.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)C(C)(C)C)c1C 10.1021/jm020289q
CHEMBL27855 199052 0 None 21379 2 Human 10.5 pKi = 10.5 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 522 7 1 7 5.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)C(C)(C)C)c1C 10.1021/jm020289q
159594 1080 38 None 1 3 Human 10.5 pKi = 10.5 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1042/cs103s107s
3487 1080 38 None 1 3 Human 10.5 pKi = 10.5 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1042/cs103s107s
CHEMBL9194 1080 38 None 1 3 Human 10.5 pKi = 10.5 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1042/cs103s107s
DB06199 1080 38 None 1 3 Human 10.5 pKi = 10.5 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1042/cs103s107s
16212950 3213 24 None None None Human 10.5 pKi = 10.5 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1021/acschembio.7b00481
989 3213 24 None None None Human 10.5 pKi = 10.5 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1021/acschembio.7b00481
CHEMBL3775234 3213 24 None None None Human 10.5 pKi = 10.5 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1021/acschembio.7b00481
P05305 3213 24 None None None Human 10.5 pKi = 10.5 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1021/acschembio.7b00481
P22387 3213 24 None None None Human 10.5 pKi = 10.5 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1021/acschembio.7b00481
P22388 3213 24 None None None Human 10.5 pKi = 10.5 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 2490 47 32 36 -4.7 NCCCC[C@@H]1NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](CC)C)CC(=O)O)CC(C)C)Cc1cnc[nH]1)CO 10.1021/acschembio.7b00481
159594 1080 38 None -1 3 Rat 10.5 pKi = 10.5 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm030528p
3487 1080 38 None -1 3 Rat 10.5 pKi = 10.5 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm030528p
CHEMBL9194 1080 38 None -1 3 Rat 10.5 pKi = 10.5 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm030528p
DB06199 1080 38 None -1 3 Rat 10.5 pKi = 10.5 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm030528p
186002 202898 17 None None None Rat 10.5 pKi = 10.5 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 531 10 2 6 5.4 CCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1C[C@H](C)C(=O)O)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1021/jm030528p
CHEMBL305576 202898 17 None None None Rat 10.5 pKi = 10.5 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 531 10 2 6 5.4 CCCCc1ccc2c(n1)[C@@H](c1ccc(OC)cc1C[C@H](C)C(=O)O)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1021/jm030528p
CHEMBL437472 484344 0 None -5 5 Rat 10.5 pKi = 10.5 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumCompound was evaluated for the binding affinity to Endothelin A receptor in the rat atrium
ChEMBL 2490 47 32 36 -4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00087a001
159594 1080 38 None 1 3 Human 10.5 pKi = 10.5 Binding
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membraneDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/acs.jmedchem.5b01781
3487 1080 38 None 1 3 Human 10.5 pKi = 10.5 Binding
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membraneDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/acs.jmedchem.5b01781
CHEMBL9194 1080 38 None 1 3 Human 10.5 pKi = 10.5 Binding
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membraneDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/acs.jmedchem.5b01781
DB06199 1080 38 None 1 3 Human 10.5 pKi = 10.5 Binding
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membraneDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/acs.jmedchem.5b01781
159594 1080 38 None 1 3 Human 10.5 pKi = 10.5 Binding
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm9505369
3487 1080 38 None 1 3 Human 10.5 pKi = 10.5 Binding
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm9505369
CHEMBL9194 1080 38 None 1 3 Human 10.5 pKi = 10.5 Binding
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm9505369
DB06199 1080 38 None 1 3 Human 10.5 pKi = 10.5 Binding
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm9505369
9936145 42882 2 None None None Human 10.4 pKi = 10.4 Binding
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 510 11 1 4 5.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)c(F)c1 10.1021/jm010237l
CHEMBL128818 42882 2 None None None Human 10.4 pKi = 10.4 Binding
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 510 11 1 4 5.3 CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)CCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(C)c(F)c1 10.1021/jm010237l
CHEMBL437472 484344 0 None -3 5 Pig 10.4 pKi = 10.4 Binding
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 2490 47 32 36 -4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
9958321 160641 0 None 19498 2 Human 10.4 pKi = 10.4 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 520 7 1 7 5.2 Cc1onc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN2CCC(C)(C)C2=O)c1C 10.1021/jm020289q
CHEMBL2113316 160641 0 None 19498 2 Human 10.4 pKi = 10.4 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 520 7 1 7 5.2 Cc1onc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN2CCC(C)(C)C2=O)c1C 10.1021/jm020289q
11813553 199554 0 None 14454 2 Human 10.4 pKi = 10.4 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 542 8 1 7 5.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)c2ccccc2)c1C 10.1021/jm020289q
CHEMBL282359 199554 0 None 14454 2 Human 10.4 pKi = 10.4 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 542 8 1 7 5.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)c2ccccc2)c1C 10.1021/jm020289q
11027595 200410 0 None 19952 2 Human 10.4 pKi = 10.4 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 508 8 1 7 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)C(C)C)c1C 10.1021/jm020289q
CHEMBL28863 200410 0 None 19952 2 Human 10.4 pKi = 10.4 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 508 8 1 7 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)C(C)C)c1C 10.1021/jm020289q
10918368 202590 0 None 21379 2 Human 10.4 pKi = 10.4 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 520 7 1 7 5.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN2CC(C)(C)CC2=O)c1C 10.1021/jm020289q
CHEMBL30405 202590 0 None 21379 2 Human 10.4 pKi = 10.4 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 520 7 1 7 5.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN2CC(C)(C)CC2=O)c1C 10.1021/jm020289q
159594 1080 38 None -1 3 Rat 10.3 pKi = 10.3 Binding
binding affinity against human Endothelin A receptorbinding affinity against human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
3487 1080 38 None -1 3 Rat 10.3 pKi = 10.3 Binding
binding affinity against human Endothelin A receptorbinding affinity against human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
CHEMBL9194 1080 38 None -1 3 Rat 10.3 pKi = 10.3 Binding
binding affinity against human Endothelin A receptorbinding affinity against human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
DB06199 1080 38 None -1 3 Rat 10.3 pKi = 10.3 Binding
binding affinity against human Endothelin A receptorbinding affinity against human Endothelin A receptor
ChEMBL 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 10.1021/jm010237l
11082168 199434 0 None 7585 2 Human 10.3 pKi = 10.3 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 548 8 1 7 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CC(F)(F)F)c1C 10.1021/jm020289q
CHEMBL281549 199434 0 None 7585 2 Human 10.3 pKi = 10.3 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 548 8 1 7 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CC(F)(F)F)c1C 10.1021/jm020289q
10929533 200520 0 None 10964 2 Human 10.3 pKi = 10.3 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 534 9 1 7 5.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C(=O)C(C)C)C2CC2)c1C 10.1021/jm020289q
CHEMBL28963 200520 0 None 10964 2 Human 10.3 pKi = 10.3 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 534 9 1 7 5.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C(=O)C(C)C)C2CC2)c1C 10.1021/jm020289q
9914310 473055 10 None 1995 2 Human 10.2 pKi = 10.2 Binding
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL8923 473055 10 None 1995 2 Human 10.2 pKi = 10.2 Binding
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1CC(c2ccc3c(c2)OCO3)C(C(=O)O)C1c1ccc(OC)cc1 10.1021/jm9505369
11762890 200811 0 None 14791 2 Human 10.2 pKi = 10.2 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 505 8 2 9 5.3 Cc1cc(NCc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)no1 10.1021/jm020289q
CHEMBL29223 200811 0 None 14791 2 Human 10.2 pKi = 10.2 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 505 8 2 9 5.3 Cc1cc(NCc2cc(-c3ncco3)ccc2-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)no1 10.1021/jm020289q
131845706 7061 8 None -11 2 Rat 10.1 pKi = 10.1 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumCompound was evaluated for the binding affinity to Endothelin A receptor in the rat atrium
ChEMBL 2562 51 34 38 -6.5 NCCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(=O)O)CCSC)[C@H](O)C)CC(=O)O)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)C(C)C)CC(=O)O)CCC(=O)N)Cc1c[nH]cn1)Cc1ccccc1 10.1021/jm00087a001
71308726 7061 8 None -11 2 Rat 10.1 pKi = 10.1 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumCompound was evaluated for the binding affinity to Endothelin A receptor in the rat atrium
ChEMBL 2562 51 34 38 -6.5 NCCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(=O)O)CCSC)[C@H](O)C)CC(=O)O)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)C(C)C)CC(=O)O)CCC(=O)N)Cc1c[nH]cn1)Cc1ccccc1 10.1021/jm00087a001
995 7061 8 None -11 2 Rat 10.1 pKi = 10.1 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumCompound was evaluated for the binding affinity to Endothelin A receptor in the rat atrium
ChEMBL 2562 51 34 38 -6.5 NCCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(=O)O)CCSC)[C@H](O)C)CC(=O)O)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)C(C)C)CC(=O)O)CCC(=O)N)Cc1c[nH]cn1)Cc1ccccc1 10.1021/jm00087a001
CHEMBL1222310 7061 8 None -11 2 Rat 10.1 pKi = 10.1 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumCompound was evaluated for the binding affinity to Endothelin A receptor in the rat atrium
ChEMBL 2562 51 34 38 -6.5 NCCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(=O)O)CCSC)[C@H](O)C)CC(=O)O)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)C(C)C)CC(=O)O)CCC(=O)N)Cc1c[nH]cn1)Cc1ccccc1 10.1021/jm00087a001
CHEMBL4524099 7061 8 None -11 2 Rat 10.1 pKi = 10.1 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumCompound was evaluated for the binding affinity to Endothelin A receptor in the rat atrium
ChEMBL 2562 51 34 38 -6.5 NCCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(=O)O)CCSC)[C@H](O)C)CC(=O)O)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)C(C)C)CC(=O)O)CCC(=O)N)Cc1c[nH]cn1)Cc1ccccc1 10.1021/jm00087a001
P13208 7061 8 None -11 2 Rat 10.1 pKi = 10.1 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumCompound was evaluated for the binding affinity to Endothelin A receptor in the rat atrium
ChEMBL 2562 51 34 38 -6.5 NCCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(=O)O)CCSC)[C@H](O)C)CC(=O)O)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)C(C)C)CC(=O)O)CCC(=O)N)Cc1c[nH]cn1)Cc1ccccc1 10.1021/jm00087a001
CHEMBL437472 484344 0 None -5 5 Rat 10.0 pKi = 10.0 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat aortaCompound was evaluated for the binding affinity to Endothelin A receptor in the rat aorta
ChEMBL 2490 47 32 36 -4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00087a001
9937336 348719 1 None 229 2 Human 10.0 pKi = 10.0 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 510 9 1 7 4.8 CCCc1nc(C)ccc1O[C@@H](C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/j.bmcl.2016.06.014
CHEMBL4559129 348719 1 None 229 2 Human 10.0 pKi = 10.0 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 510 9 1 7 4.8 CCCc1nc(C)ccc1O[C@@H](C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/j.bmcl.2016.06.014
9865409 202412 0 None 199 2 Human 9.9 pKi = 9.9 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 394 8 1 6 3.2 COc1cc(C)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
CHEMBL303631 202412 0 None 199 2 Human 9.9 pKi = 9.9 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 394 8 1 6 3.2 COc1cc(C)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
12286 1953 39 None 1348 2 Human 9.9 pKi = 9.9 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 10.1016/s0014-2999(98)00891-7
6433095 1953 39 None 1348 2 Human 9.9 pKi = 9.9 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 10.1016/s0014-2999(98)00891-7
CHEMBL109648 1953 39 None 1348 2 Human 9.9 pKi = 9.9 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 10.1016/s0014-2999(98)00891-7
DB06677 1953 39 None 1348 2 Human 9.9 pKi = 9.9 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 10.1016/s0014-2999(98)00891-7
9894460 473657 11 None 41 2 Human 9.9 pKi = 9.9 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/s0014-2999(98)00891-7
CHEMBL8978 473657 11 None 41 2 Human 9.9 pKi = 9.9 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/s0014-2999(98)00891-7
9894460 473657 11 None 41 2 Human 9.9 pKi = 9.9 Binding
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1021/jm9505369
CHEMBL8978 473657 11 None 41 2 Human 9.9 pKi = 9.9 Binding
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1021/jm9505369
12286 1953 39 None 1348 2 Human 9.9 pKi = 9.9 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 10.1021/jm980217s
6433095 1953 39 None 1348 2 Human 9.9 pKi = 9.9 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 10.1021/jm980217s
CHEMBL109648 1953 39 None 1348 2 Human 9.9 pKi = 9.9 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 10.1021/jm980217s
DB06677 1953 39 None 1348 2 Human 9.9 pKi = 9.9 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 10.1021/jm980217s
CHEMBL437472 484344 0 None -4 5 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]Endothelin-1 from human recombinant ETA receptor expressed in CHOK1 cells after 2 hrsDisplacement of [125I]Endothelin-1 from human recombinant ETA receptor expressed in CHOK1 cells after 2 hrs
ChEMBL 2490 47 32 36 -4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/j.bmcl.2013.01.025
CHEMBL437472 484344 0 None -4 5 Human 9.9 pKi = 9.9 Binding
Displacement of radiolabeled endothelin-1 from human endothelin ETA receptorDisplacement of radiolabeled endothelin-1 from human endothelin ETA receptor
ChEMBL 2490 47 32 36 -4.7 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](CO)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm8007618
10973161 201182 0 None 6456 2 Human 9.8 pKi = 9.8 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 502 8 2 9 4.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CNc2ccncn2)c1C 10.1021/jm020289q
CHEMBL29464 201182 0 None 6456 2 Human 9.8 pKi = 9.8 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 502 8 2 9 4.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CNc2ccncn2)c1C 10.1021/jm020289q
11103326 332659 0 None 12589 2 Human 9.8 pKi = 9.8 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 520 8 1 7 5.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)CC(F)(F)F)c1C 10.1021/jm020289q
CHEMBL431296 332659 0 None 12589 2 Human 9.8 pKi = 9.8 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 520 8 1 7 5.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)CC(F)(F)F)c1C 10.1021/jm020289q
23670447 6168 2 None 537 2 Human 9.8 pKi = 9.8 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0014-2999(98)00891-7
9871594 6168 2 None 537 2 Human 9.8 pKi = 9.8 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0014-2999(98)00891-7
999 6168 2 None 537 2 Human 9.8 pKi = 9.8 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0014-2999(98)00891-7
CHEMBL1204799 6168 2 None 537 2 Human 9.8 pKi = 9.8 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0014-2999(98)00891-7
CHEMBL25438 6168 2 None 537 2 Human 9.8 pKi = 9.8 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0014-2999(98)00891-7
9870830 473662 29 None 812 2 Human 9.8 pKi = 9.8 Binding
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9505369
CHEMBL8981 473662 29 None 812 2 Human 9.8 pKi = 9.8 Binding
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 506 8 1 9 3.8 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OC)c2)cc1 10.1021/jm9505369
23670447 6168 2 None 537 2 Human 9.8 pKi = 9.8 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1021/jm980217s
9871594 6168 2 None 537 2 Human 9.8 pKi = 9.8 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1021/jm980217s
999 6168 2 None 537 2 Human 9.8 pKi = 9.8 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1021/jm980217s
CHEMBL1204799 6168 2 None 537 2 Human 9.8 pKi = 9.8 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1021/jm980217s
CHEMBL25438 6168 2 None 537 2 Human 9.8 pKi = 9.8 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1021/jm980217s
108002 7104 25 None 56 2 Human 9.7 pKi = 9.7 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 10.1021/jm970101g
3528 7104 25 None 56 2 Human 9.7 pKi = 9.7 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 10.1021/jm970101g
CHEMBL8823 7104 25 None 56 2 Human 9.7 pKi = 9.7 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 10.1021/jm970101g
14516 397 1 None 6 2 Human 9.7 pKi = 9.7 Binding
Binding affinity to human ETA receptor transfected in CHO cell membrane assessed as inhibition constant incubated for 3 hrs by 125I-labelled ET-1 saturation binding assayBinding affinity to human ETA receptor transfected in CHO cell membrane assessed as inhibition constant incubated for 3 hrs by 125I-labelled ET-1 saturation binding assay
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1042/cs103s107s
9916235 397 1 None 6 2 Human 9.7 pKi = 9.7 Binding
Binding affinity to human ETA receptor transfected in CHO cell membrane assessed as inhibition constant incubated for 3 hrs by 125I-labelled ET-1 saturation binding assayBinding affinity to human ETA receptor transfected in CHO cell membrane assessed as inhibition constant incubated for 3 hrs by 125I-labelled ET-1 saturation binding assay
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1042/cs103s107s
CHEMBL111277 397 1 None 6 2 Human 9.7 pKi = 9.7 Binding
Binding affinity to human ETA receptor transfected in CHO cell membrane assessed as inhibition constant incubated for 3 hrs by 125I-labelled ET-1 saturation binding assayBinding affinity to human ETA receptor transfected in CHO cell membrane assessed as inhibition constant incubated for 3 hrs by 125I-labelled ET-1 saturation binding assay
ChEMBL 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 10.1042/cs103s107s
108002 7104 25 None 56 2 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane at 30 degC incubated for 60 mins by radioligand competition binding assayDisplacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane at 30 degC incubated for 60 mins by radioligand competition binding assay
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 10.1016/s0014-2999(98)00891-7
3528 7104 25 None 56 2 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane at 30 degC incubated for 60 mins by radioligand competition binding assayDisplacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane at 30 degC incubated for 60 mins by radioligand competition binding assay
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 10.1016/s0014-2999(98)00891-7
CHEMBL8823 7104 25 None 56 2 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane at 30 degC incubated for 60 mins by radioligand competition binding assayDisplacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane at 30 degC incubated for 60 mins by radioligand competition binding assay
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 10.1016/s0014-2999(98)00891-7
11754273 201112 0 None 21877 2 Human 9.7 pKi = 9.7 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 466 7 2 7 4.1 CC(=O)NCc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm000105c
CHEMBL29422 201112 0 None 21877 2 Human 9.7 pKi = 9.7 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 466 7 2 7 4.1 CC(=O)NCc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm000105c
11059912 199548 0 None 23988 2 Human 9.7 pKi = 9.7 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 481 9 1 7 5.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2COCC(C)C)c1C 10.1021/jm020289q
CHEMBL282303 199548 0 None 23988 2 Human 9.7 pKi = 9.7 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 481 9 1 7 5.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2COCC(C)C)c1C 10.1021/jm020289q
10972867 199894 0 None 19952 2 Human 9.7 pKi = 9.7 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 480 7 1 7 4.4 CC(=O)N(C)Cc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm020289q
CHEMBL284656 199894 0 None 19952 2 Human 9.7 pKi = 9.7 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 480 7 1 7 4.4 CC(=O)N(C)Cc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm020289q
11754273 201112 0 None 21877 2 Human 9.7 pKi = 9.7 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 466 7 2 7 4.1 CC(=O)NCc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm020289q
CHEMBL29422 201112 0 None 21877 2 Human 9.7 pKi = 9.7 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 466 7 2 7 4.1 CC(=O)NCc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm020289q
131845706 7061 8 None -11 2 Rat 9.6 pKi = 9.6 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat aortaCompound was evaluated for the binding affinity to Endothelin A receptor in the rat aorta
ChEMBL 2562 51 34 38 -6.5 NCCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(=O)O)CCSC)[C@H](O)C)CC(=O)O)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)C(C)C)CC(=O)O)CCC(=O)N)Cc1c[nH]cn1)Cc1ccccc1 10.1021/jm00087a001
71308726 7061 8 None -11 2 Rat 9.6 pKi = 9.6 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat aortaCompound was evaluated for the binding affinity to Endothelin A receptor in the rat aorta
ChEMBL 2562 51 34 38 -6.5 NCCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(=O)O)CCSC)[C@H](O)C)CC(=O)O)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)C(C)C)CC(=O)O)CCC(=O)N)Cc1c[nH]cn1)Cc1ccccc1 10.1021/jm00087a001
995 7061 8 None -11 2 Rat 9.6 pKi = 9.6 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat aortaCompound was evaluated for the binding affinity to Endothelin A receptor in the rat aorta
ChEMBL 2562 51 34 38 -6.5 NCCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(=O)O)CCSC)[C@H](O)C)CC(=O)O)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)C(C)C)CC(=O)O)CCC(=O)N)Cc1c[nH]cn1)Cc1ccccc1 10.1021/jm00087a001
CHEMBL1222310 7061 8 None -11 2 Rat 9.6 pKi = 9.6 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat aortaCompound was evaluated for the binding affinity to Endothelin A receptor in the rat aorta
ChEMBL 2562 51 34 38 -6.5 NCCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(=O)O)CCSC)[C@H](O)C)CC(=O)O)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)C(C)C)CC(=O)O)CCC(=O)N)Cc1c[nH]cn1)Cc1ccccc1 10.1021/jm00087a001
CHEMBL4524099 7061 8 None -11 2 Rat 9.6 pKi = 9.6 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat aortaCompound was evaluated for the binding affinity to Endothelin A receptor in the rat aorta
ChEMBL 2562 51 34 38 -6.5 NCCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(=O)O)CCSC)[C@H](O)C)CC(=O)O)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)C(C)C)CC(=O)O)CCC(=O)N)Cc1c[nH]cn1)Cc1ccccc1 10.1021/jm00087a001
P13208 7061 8 None -11 2 Rat 9.6 pKi = 9.6 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat aortaCompound was evaluated for the binding affinity to Endothelin A receptor in the rat aorta
ChEMBL 2562 51 34 38 -6.5 NCCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(=O)O)CCSC)[C@H](O)C)CC(=O)O)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(cc1)O)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N2)CO)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)C(C)C)CC(=O)O)CCC(=O)N)Cc1c[nH]cn1)Cc1ccccc1 10.1021/jm00087a001
46228086 443664 0 None 707 2 Mouse 9.6 pKi = 9.6 Binding
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 598 10 1 9 4.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCBr)c2)cc1 10.1016/j.bmc.2009.08.058
CHEMBL594265 443664 0 None 707 2 Mouse 9.6 pKi = 9.6 Binding
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 598 10 1 9 4.6 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCBr)c2)cc1 10.1016/j.bmc.2009.08.058
11123603 201906 0 None 14125 2 Human 9.5 pKi = 9.5 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 475 7 1 8 4.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cn2ccnc2)c1C 10.1021/jm020289q
CHEMBL30009 201906 0 None 14125 2 Human 9.5 pKi = 9.5 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 475 7 1 8 4.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cn2ccnc2)c1C 10.1021/jm020289q
11730445 202015 0 None 4677 2 Human 9.5 pKi = 9.5 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 475 7 1 8 4.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cn2cccn2)c1C 10.1021/jm020289q
CHEMBL30092 202015 0 None 4677 2 Human 9.5 pKi = 9.5 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 475 7 1 8 4.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cn2cccn2)c1C 10.1021/jm020289q
46228118 466077 0 None 263 2 Mouse 9.4 pKi = 9.4 Binding
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 690 13 1 12 4.7 COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OCCOc3ccc(S(C)(=O)=O)cc3)cc2)cc(OC)c1OC 10.1016/j.bmc.2009.08.058
CHEMBL611626 466077 0 None 263 2 Mouse 9.4 pKi = 9.4 Binding
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 690 13 1 12 4.7 COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OCCOc3ccc(S(C)(=O)=O)cc3)cc2)cc(OC)c1OC 10.1016/j.bmc.2009.08.058
23670447 6168 2 None 537 2 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assayDisplacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assay
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0014-2999(98)00891-7
9871594 6168 2 None 537 2 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assayDisplacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assay
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0014-2999(98)00891-7
999 6168 2 None 537 2 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assayDisplacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assay
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0014-2999(98)00891-7
CHEMBL1204799 6168 2 None 537 2 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assayDisplacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assay
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0014-2999(98)00891-7
CHEMBL25438 6168 2 None 537 2 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assayDisplacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assay
ChEMBL 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 10.1016/s0014-2999(98)00891-7
11082049 199759 0 None 933 2 Human 9.4 pKi = 9.4 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 534 7 1 7 5.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN2CCCC(C)(C)C2=O)c1C 10.1021/jm020289q
CHEMBL283610 199759 0 None 933 2 Human 9.4 pKi = 9.4 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 534 7 1 7 5.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN2CCCC(C)(C)C2=O)c1C 10.1021/jm020289q
10432263 202244 0 None 85 2 Human 9.4 pKi = 9.4 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 420 8 1 6 3.4 COc1nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)nc2c1CCC2 10.1021/jm960274q
CHEMBL302564 202244 0 None 85 2 Human 9.4 pKi = 9.4 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 420 8 1 6 3.4 COc1nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)nc2c1CCC2 10.1021/jm960274q
10864118 201591 0 None 4265 2 Human 9.4 pKi = 9.4 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 508 8 1 7 5.2 CC(=O)N(Cc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C)C(C)C 10.1021/jm020289q
CHEMBL29775 201591 0 None 4265 2 Human 9.4 pKi = 9.4 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 508 8 1 7 5.2 CC(=O)N(Cc1cc(-c2ncco2)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C)C(C)C 10.1021/jm020289q
216235 7338 38 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm9700068
3548 7338 38 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm9700068
3950 7338 38 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm9700068
CHEMBL282724 7338 38 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm9700068
DB06268 7338 38 None 1 2 Human 9.4 pKi = 9.4 Binding
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm9700068
216235 7338 38 None -1 2 Rat 9.4 pKi = 9.4 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
3548 7338 38 None -1 2 Rat 9.4 pKi = 9.4 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
3950 7338 38 None -1 2 Rat 9.4 pKi = 9.4 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
CHEMBL282724 7338 38 None -1 2 Rat 9.4 pKi = 9.4 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
DB06268 7338 38 None -1 2 Rat 9.4 pKi = 9.4 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1021/jm030528p
216235 7338 38 None 1 2 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]ET-1 from ETA receptor in human TE-671 cells Membrane assessed as inhibition constant incubated for 16 to 18 hrs by gamma counter analysisDisplacement of [125I]ET-1 from ETA receptor in human TE-671 cells Membrane assessed as inhibition constant incubated for 16 to 18 hrs by gamma counter analysis
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1016/s0014-2999(98)00891-7
3548 7338 38 None 1 2 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]ET-1 from ETA receptor in human TE-671 cells Membrane assessed as inhibition constant incubated for 16 to 18 hrs by gamma counter analysisDisplacement of [125I]ET-1 from ETA receptor in human TE-671 cells Membrane assessed as inhibition constant incubated for 16 to 18 hrs by gamma counter analysis
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1016/s0014-2999(98)00891-7
3950 7338 38 None 1 2 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]ET-1 from ETA receptor in human TE-671 cells Membrane assessed as inhibition constant incubated for 16 to 18 hrs by gamma counter analysisDisplacement of [125I]ET-1 from ETA receptor in human TE-671 cells Membrane assessed as inhibition constant incubated for 16 to 18 hrs by gamma counter analysis
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1016/s0014-2999(98)00891-7
CHEMBL282724 7338 38 None 1 2 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]ET-1 from ETA receptor in human TE-671 cells Membrane assessed as inhibition constant incubated for 16 to 18 hrs by gamma counter analysisDisplacement of [125I]ET-1 from ETA receptor in human TE-671 cells Membrane assessed as inhibition constant incubated for 16 to 18 hrs by gamma counter analysis
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1016/s0014-2999(98)00891-7
DB06268 7338 38 None 1 2 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]ET-1 from ETA receptor in human TE-671 cells Membrane assessed as inhibition constant incubated for 16 to 18 hrs by gamma counter analysisDisplacement of [125I]ET-1 from ETA receptor in human TE-671 cells Membrane assessed as inhibition constant incubated for 16 to 18 hrs by gamma counter analysis
ChEMBL 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C 10.1016/s0014-2999(98)00891-7
108002 7104 25 None 56 2 Human 9.4 pKi = 9.4 Binding
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 10.1021/jm00037a003
3528 7104 25 None 56 2 Human 9.4 pKi = 9.4 Binding
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 10.1021/jm00037a003
CHEMBL8823 7104 25 None 56 2 Human 9.4 pKi = 9.4 Binding
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 10.1021/jm00037a003
108002 7104 25 None 56 2 Human 9.4 pKi = 9.4 Binding
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 10.1021/jm9505369
3528 7104 25 None 56 2 Human 9.4 pKi = 9.4 Binding
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 10.1021/jm9505369
CHEMBL8823 7104 25 None 56 2 Human 9.4 pKi = 9.4 Binding
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H]([C@@H]([C@H]2c1ccc2c(c1)OCO2)C(=O)O)c1ccc(cc1OCC(=O)O)OC 10.1021/jm9505369
44339756 220292 0 None None None Human 9.4 pKi = 9.4 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 454 6 1 8 4.0 Cc1cc2c(cc1CC(=O)c1ccsc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm980217s
CHEMBL326059 220292 0 None None None Human 9.4 pKi = 9.4 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 454 6 1 8 4.0 Cc1cc2c(cc1CC(=O)c1ccsc1S(=O)(=O)Nc1onc(C)c1Cl)OCO2 10.1021/jm980217s
9849547 365839 0 None 34 2 Human 9.4 pKi = 9.4 Binding
Tested for in vitro inhibition of [125I]ET1 binding to CHO cells expressing human Endothelin A receptorTested for in vitro inhibition of [125I]ET1 binding to CHO cells expressing human Endothelin A receptor
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1OCC(=O)O)[C@@H](C(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
CHEMBL48196 365839 0 None 34 2 Human 9.4 pKi = 9.4 Binding
Tested for in vitro inhibition of [125I]ET1 binding to CHO cells expressing human Endothelin A receptorTested for in vitro inhibition of [125I]ET1 binding to CHO cells expressing human Endothelin A receptor
ChEMBL 520 10 2 7 4.7 CCCOc1ccc2c(c1)[C@H](c1ccc(OC)cc1OCC(=O)O)[C@@H](C(=O)O)[C@@H]2c1ccc2c(c1)OCO2 10.1016/s0960-894x(01)00273-6
11734435 201432 0 None 6456 2 Human 9.4 pKi = 9.4 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 562 9 1 7 6.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CC2CCCCC2)c1C 10.1021/jm020289q
CHEMBL29652 201432 0 None 6456 2 Human 9.4 pKi = 9.4 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 562 9 1 7 6.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)CC2CCCCC2)c1C 10.1021/jm020289q
9915028 23715 19 None 21877 3 Human 9.3 pKi = 9.3 Binding
Affinity Biochemical interaction ([125I]-endothelin-1 saturation binding assay) EUB0000348aPTSA EDNRAAffinity Biochemical interaction ([125I]-endothelin-1 saturation binding assay) EUB0000348aPTSA EDNRA
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.6019/CHEMBL5210307
CHEMBL111612 23715 19 None 21877 3 Human 9.3 pKi = 9.3 Binding
Affinity Biochemical interaction ([125I]-endothelin-1 saturation binding assay) EUB0000348aPTSA EDNRAAffinity Biochemical interaction ([125I]-endothelin-1 saturation binding assay) EUB0000348aPTSA EDNRA
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.6019/CHEMBL5210307
9915028 23715 19 None 21877 3 Human 9.3 pKi = 9.3 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm010237l
CHEMBL111612 23715 19 None 21877 3 Human 9.3 pKi = 9.3 Binding
Binding affinity against endothelin A receptor in MMQ cells in ratBinding affinity against endothelin A receptor in MMQ cells in rat
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm010237l
9915028 23715 19 None 21877 3 Human 9.3 pKi = 9.3 Binding
Binding affinity to human ETA receptor transfected in CHO cell membrane assessed as inhibition constant incubated for 4 hrs by 125I-labelled ET-1 saturation binding assayBinding affinity to human ETA receptor transfected in CHO cell membrane assessed as inhibition constant incubated for 4 hrs by 125I-labelled ET-1 saturation binding assay
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1042/cs103s107s
CHEMBL111612 23715 19 None 21877 3 Human 9.3 pKi = 9.3 Binding
Binding affinity to human ETA receptor transfected in CHO cell membrane assessed as inhibition constant incubated for 4 hrs by 125I-labelled ET-1 saturation binding assayBinding affinity to human ETA receptor transfected in CHO cell membrane assessed as inhibition constant incubated for 4 hrs by 125I-labelled ET-1 saturation binding assay
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1042/cs103s107s
177372766 394391 0 None 28183 2 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assayDisplacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assay
ChEMBL 532 15 1 6 5.9 CCCCN(CCCC)C(=O)CN1[C@H](c2cc(OC)c3c(c2)OCO3)C[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1016/s0014-2999(98)00891-7
CHEMBL5687007 394391 0 None 28183 2 Human 9.3 pKi = 9.3 Binding
Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assayDisplacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assay
ChEMBL 532 15 1 6 5.9 CCCCN(CCCC)C(=O)CN1[C@H](c2cc(OC)c3c(c2)OCO3)C[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1016/s0014-2999(98)00891-7
9915028 23715 19 None 21877 3 Human 9.3 pKi = 9.3 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
CHEMBL111612 23715 19 None 21877 3 Human 9.3 pKi = 9.3 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.1021/jm980217s
9915028 23715 19 None 21877 3 Human 9.3 pKi = 9.3 Binding
[125I]-endothelin-1 saturation binding[125I]-endothelin-1 saturation binding
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.6019/CHEMBL4507258
CHEMBL111612 23715 19 None 21877 3 Human 9.3 pKi = 9.3 Binding
[125I]-endothelin-1 saturation binding[125I]-endothelin-1 saturation binding
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@H](c2cc(OC)c3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1CC(C)(C)CCC 10.6019/CHEMBL4507258
10815239 218164 0 None 125 2 Human 9.3 pKi = 9.3 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 500 10 1 7 5.0 COc1ccc(OC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
CHEMBL320224 218164 0 None 125 2 Human 9.3 pKi = 9.3 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 500 10 1 7 5.0 COc1ccc(OC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
11794992 19311 0 None 39810 2 Human 9.3 pKi = 9.3 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 395 5 1 6 4.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cocn3)cc2)c1C 10.1021/jm000105c
CHEMBL104848 19311 0 None 39810 2 Human 9.3 pKi = 9.3 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 395 5 1 6 4.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cocn3)cc2)c1C 10.1021/jm000105c
11812665 199956 0 None 18197 2 Human 9.2 pKi = 9.2 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 467 8 1 7 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2COC(C)C)c1C 10.1021/jm020289q
CHEMBL285118 199956 0 None 18197 2 Human 9.2 pKi = 9.2 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 467 8 1 7 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2COC(C)C)c1C 10.1021/jm020289q
11124545 201501 0 None 4168 2 Human 9.2 pKi = 9.2 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 557 9 1 8 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)Cc2ccccn2)c1C 10.1021/jm020289q
CHEMBL29710 201501 0 None 4168 2 Human 9.2 pKi = 9.2 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 557 9 1 8 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)C(=O)Cc2ccccn2)c1C 10.1021/jm020289q
10907333 202178 0 None 1819 2 Human 9.2 pKi = 9.2 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 508 7 2 7 4.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CC(=O)NC(C)(C)C)c1C 10.1021/jm020289q
CHEMBL30215 202178 0 None 1819 2 Human 9.2 pKi = 9.2 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 508 7 2 7 4.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CC(=O)NC(C)(C)C)c1C 10.1021/jm020289q
10786696 202844 0 None 223 2 Human 9.2 pKi = 9.2 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 392 8 1 5 3.8 CCc1cc(C)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
CHEMBL305270 202844 0 None 223 2 Human 9.2 pKi = 9.2 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 392 8 1 5 3.8 CCc1cc(C)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
11081276 201354 0 None 2238 2 Human 9.1 pKi = 9.1 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 476 7 1 8 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cc2ncco2)c1C 10.1021/jm020289q
CHEMBL29598 201354 0 None 2238 2 Human 9.1 pKi = 9.1 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 476 7 1 8 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2Cc2ncco2)c1C 10.1021/jm020289q
107810 3461 29 None 8128 2 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assayDisplacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assay
ChEMBL 604 12 4 6 3.4 CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccccn1)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C 10.1016/s0014-2999(98)00891-7
998 3461 29 None 8128 2 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assayDisplacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assay
ChEMBL 604 12 4 6 3.4 CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccccn1)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C 10.1016/s0014-2999(98)00891-7
CHEMBL352396 3461 29 None 8128 2 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assayDisplacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assay
ChEMBL 604 12 4 6 3.4 CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccccn1)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C 10.1016/s0014-2999(98)00891-7
10973218 201108 0 None 3388 2 Human 9.1 pKi = 9.1 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 506 8 2 7 5.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CNCC(F)(F)F)c1C 10.1021/jm020289q
CHEMBL29420 201108 0 None 3388 2 Human 9.1 pKi = 9.1 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 506 8 2 7 5.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CNCC(F)(F)F)c1C 10.1021/jm020289q
44311692 203215 0 None -3 2 Human 9.1 pKi = 9.1 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 667 13 3 7 4.5 C=CCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL308102 203215 0 None -3 2 Human 9.1 pKi = 9.1 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 667 13 3 7 4.5 C=CCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
9822616 240581 0 None 17782 2 Human 9.1 pKi = 9.1 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 406 5 1 6 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncccn3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL359273 240581 0 None 17782 2 Human 9.1 pKi = 9.1 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 406 5 1 6 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncccn3)cc2)c1C 10.1016/s0960-894x(01)00791-0
9979632 202954 0 None 41 2 Human 9.1 pKi = 9.1 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 422 8 1 7 2.8 COc1nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)nc2c1CCO2 10.1021/jm960274q
CHEMBL305980 202954 0 None 41 2 Human 9.1 pKi = 9.1 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 422 8 1 7 2.8 COc1nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)nc2c1CCO2 10.1021/jm960274q
107810 3461 29 None 8128 2 Human 9.0 pKi = 9 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 604 12 4 6 3.4 CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccccn1)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C 10.1016/s0014-2999(98)00891-7
998 3461 29 None 8128 2 Human 9.0 pKi = 9 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 604 12 4 6 3.4 CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccccn1)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C 10.1016/s0014-2999(98)00891-7
CHEMBL352396 3461 29 None 8128 2 Human 9.0 pKi = 9 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 604 12 4 6 3.4 CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccccn1)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C 10.1016/s0014-2999(98)00891-7
17979744 42118 0 None None None Human 9.0 pKi = 9 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 657 10 1 8 6.6 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CN3CCC(C)(C)C3=O)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
CHEMBL12703 42118 0 None None None Human 9.0 pKi = 9 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 657 10 1 8 6.6 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CN3CCC(C)(C)C3=O)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
197712 807 76 None 11 2 Human 9.0 pKi = 9 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1021/jm960274q
3951 807 76 None 11 2 Human 9.0 pKi = 9 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1021/jm960274q
4337 807 76 None 11 2 Human 9.0 pKi = 9 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1021/jm960274q
6918493 807 76 None 11 2 Human 9.0 pKi = 9 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1021/jm960274q
CHEMBL1111 807 76 None 11 2 Human 9.0 pKi = 9 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1021/jm960274q
CHEMBL302753 807 76 None 11 2 Human 9.0 pKi = 9 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1021/jm960274q
DB06403 807 76 None 11 2 Human 9.0 pKi = 9 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 10.1021/jm960274q
10763862 328214 0 None 1096 2 Human 9.0 pKi = 9 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 406 9 1 5 4.0 CCc1cc(CC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
CHEMBL418326 328214 0 None 1096 2 Human 9.0 pKi = 9 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 406 9 1 5 4.0 CCc1cc(CC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
11733544 199453 0 None 7244 2 Human 9.0 pKi = 9 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 480 7 1 7 4.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CC(=O)N(C)C)c1C 10.1021/jm020289q
CHEMBL281668 199453 0 None 7244 2 Human 9.0 pKi = 9 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 480 7 1 7 4.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CC(=O)N(C)C)c1C 10.1021/jm020289q
11103112 200054 0 None 4570 2 Human 9.0 pKi = 9 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 501 8 1 7 6.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2COc2ccccc2)c1C 10.1021/jm020289q
CHEMBL28586 200054 0 None 4570 2 Human 9.0 pKi = 9 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 501 8 1 7 6.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2COc2ccccc2)c1C 10.1021/jm020289q
45257114 443885 0 None 218 2 Mouse 9.0 pKi = 9.0 Binding
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 538 10 1 9 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCF)c2)cc1 10.1016/j.bmc.2009.08.058
CHEMBL594482 443885 0 None 218 2 Mouse 9.0 pKi = 9.0 Binding
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 538 10 1 9 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCF)c2)cc1 10.1016/j.bmc.2009.08.058
178103 332704 22 None 100 2 Human 9.0 pKi = 9.0 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 506 10 2 7 4.6 CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCCO)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1021/jm970101g
CHEMBL431651 332704 22 None 100 2 Human 9.0 pKi = 9.0 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 506 10 2 7 4.6 CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCCO)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1021/jm970101g
DB06460 332704 22 None 100 2 Human 9.0 pKi = 9.0 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 506 10 2 7 4.6 CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCCO)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1021/jm970101g
178103 332704 22 None 100 2 Human 9.0 pKi = 9.0 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 506 10 2 7 4.6 CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCCO)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0014-2999(98)00891-7
CHEMBL431651 332704 22 None 100 2 Human 9.0 pKi = 9.0 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 506 10 2 7 4.6 CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCCO)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0014-2999(98)00891-7
DB06460 332704 22 None 100 2 Human 9.0 pKi = 9.0 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 506 10 2 7 4.6 CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCCO)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1016/s0014-2999(98)00891-7
45257114 443885 0 None 218 2 Mouse 9.0 pKi = 9.0 Binding
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 538 10 1 9 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCF)c2)cc1 10.1021/jm101110w
CHEMBL594482 443885 0 None 218 2 Mouse 9.0 pKi = 9.0 Binding
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 538 10 1 9 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCF)c2)cc1 10.1021/jm101110w
178103 332704 22 None 100 2 Human 9.0 pKi = 9.0 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 506 10 2 7 4.6 CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCCO)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1021/jm980217s
CHEMBL431651 332704 22 None 100 2 Human 9.0 pKi = 9.0 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 506 10 2 7 4.6 CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCCO)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1021/jm980217s
DB06460 332704 22 None 100 2 Human 9.0 pKi = 9.0 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 506 10 2 7 4.6 CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1OCCO)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1021/jm980217s
46228117 443341 0 None 1 2 Mouse 8.9 pKi = 8.9 Binding
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 690 13 1 12 4.7 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOc3ccc(S(C)(=O)=O)cc3)c2)cc1 10.1016/j.bmc.2009.08.058
CHEMBL593928 443341 0 None 1 2 Mouse 8.9 pKi = 8.9 Binding
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 690 13 1 12 4.7 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOc3ccc(S(C)(=O)=O)cc3)c2)cc1 10.1016/j.bmc.2009.08.058
123883 38550 0 None 457 2 Human 8.9 pKi = 8.9 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 927 12 9 11 0.8 CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1016/s0014-2999(98)00891-7
15515963 38550 0 None 457 2 Human 8.9 pKi = 8.9 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 927 12 9 11 0.8 CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1016/s0014-2999(98)00891-7
CHEMBL1205177 38550 0 None 457 2 Human 8.9 pKi = 8.9 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 927 12 9 11 0.8 CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1016/s0014-2999(98)00891-7
CHEMBL6070927 38550 0 None 457 2 Human 8.9 pKi = 8.9 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 927 12 9 11 0.8 CC(C)C[C@@H]1NC(=O)[C@@H](c2cccs2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N2CCN(c3ccccc3)CC2)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O 10.1016/s0014-2999(98)00891-7
10840560 19010 0 None 2 2 Human 8.9 pKi = 8.9 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 558 13 1 8 5.2 COc1cc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc(OC)c1OC 10.1021/jm9910425
CHEMBL103201 19010 0 None 2 2 Human 8.9 pKi = 8.9 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 558 13 1 8 5.2 COc1cc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc(OC)c1OC 10.1021/jm9910425
13016 1378 15 None 1 4 Human 8.9 pKi = 8.9 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1016/s0960-894x(01)00791-0
9843631 1378 15 None 1 4 Human 8.9 pKi = 8.9 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1016/s0960-894x(01)00791-0
CHEMBL24461 1378 15 None 1 4 Human 8.9 pKi = 8.9 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1016/s0960-894x(01)00791-0
13016 1378 15 None 1 4 Human 8.9 pKi = 8.9 Binding
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm300682j
9843631 1378 15 None 1 4 Human 8.9 pKi = 8.9 Binding
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm300682j
CHEMBL24461 1378 15 None 1 4 Human 8.9 pKi = 8.9 Binding
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm300682j
13016 1378 15 None -1 4 Rat 8.9 pKi = 8.9 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm030528p
9843631 1378 15 None -1 4 Rat 8.9 pKi = 8.9 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm030528p
CHEMBL24461 1378 15 None -1 4 Rat 8.9 pKi = 8.9 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm030528p
13016 1378 15 None 1 4 Human 8.9 pKi = 8.9 Binding
Compound was evaluated for its binding affinity towards human Endothelin A receptorCompound was evaluated for its binding affinity towards human Endothelin A receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm020138n
9843631 1378 15 None 1 4 Human 8.9 pKi = 8.9 Binding
Compound was evaluated for its binding affinity towards human Endothelin A receptorCompound was evaluated for its binding affinity towards human Endothelin A receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm020138n
CHEMBL24461 1378 15 None 1 4 Human 8.9 pKi = 8.9 Binding
Compound was evaluated for its binding affinity towards human Endothelin A receptorCompound was evaluated for its binding affinity towards human Endothelin A receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm020138n
13016 1378 15 None -1 4 Rat 8.9 pKi = 8.9 Binding
Displacement of [125I]-ET1 from ETA receptor in A10 rat thoracic aorta smooth muscle after 3 hrs by scintillation counting methodDisplacement of [125I]-ET1 from ETA receptor in A10 rat thoracic aorta smooth muscle after 3 hrs by scintillation counting method
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1016/j.bmcl.2016.06.014
9843631 1378 15 None -1 4 Rat 8.9 pKi = 8.9 Binding
Displacement of [125I]-ET1 from ETA receptor in A10 rat thoracic aorta smooth muscle after 3 hrs by scintillation counting methodDisplacement of [125I]-ET1 from ETA receptor in A10 rat thoracic aorta smooth muscle after 3 hrs by scintillation counting method
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1016/j.bmcl.2016.06.014
CHEMBL24461 1378 15 None -1 4 Rat 8.9 pKi = 8.9 Binding
Displacement of [125I]-ET1 from ETA receptor in A10 rat thoracic aorta smooth muscle after 3 hrs by scintillation counting methodDisplacement of [125I]-ET1 from ETA receptor in A10 rat thoracic aorta smooth muscle after 3 hrs by scintillation counting method
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1016/j.bmcl.2016.06.014
51003306 120855 0 None 295 2 Mouse 8.9 pKi = 8.9 Binding
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 670 19 1 12 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCF)c2)cc1 10.1021/jm101110w
CHEMBL1672880 120855 0 None 295 2 Mouse 8.9 pKi = 8.9 Binding
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 670 19 1 12 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCF)c2)cc1 10.1021/jm101110w
13016 1378 15 None 1 4 Human 8.9 pKi = 8.9 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm000105c
9843631 1378 15 None 1 4 Human 8.9 pKi = 8.9 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm000105c
CHEMBL24461 1378 15 None 1 4 Human 8.9 pKi = 8.9 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm000105c
13016 1378 15 None 1 4 Human 8.9 pKi = 8.9 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm020289q
9843631 1378 15 None 1 4 Human 8.9 pKi = 8.9 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm020289q
CHEMBL24461 1378 15 None 1 4 Human 8.9 pKi = 8.9 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm020289q
13016 1378 15 None 1 4 Human 8.9 pKi = 8.9 Binding
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm030480f
9843631 1378 15 None 1 4 Human 8.9 pKi = 8.9 Binding
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm030480f
CHEMBL24461 1378 15 None 1 4 Human 8.9 pKi = 8.9 Binding
Inhibitory concentration against Endothelin A receptorInhibitory concentration against Endothelin A receptor
ChEMBL 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10.1021/jm030480f
44311810 203080 5 None -6 2 Human 8.8 pKi = 8.8 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
44312023 203080 5 None -6 2 Human 8.8 pKi = 8.8 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
9830098 203080 5 None -6 2 Human 8.8 pKi = 8.8 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
9938533 203080 5 None -6 2 Human 8.8 pKi = 8.8 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
CHEMBL307033 203080 5 None -6 2 Human 8.8 pKi = 8.8 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
CHEMBL310919 203080 5 None -6 2 Human 8.8 pKi = 8.8 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
CHEMBL311854 203080 5 None -6 2 Human 8.8 pKi = 8.8 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
CHEMBL72295 203080 5 None -6 2 Human 8.8 pKi = 8.8 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
10553793 18809 0 None 75 2 Human 8.8 pKi = 8.8 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 512 11 2 6 4.8 Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(C(=O)O)cc2)(c2ccccc2)c2ccccc2)n1 10.1021/jm9910425
CHEMBL101742 18809 0 None 75 2 Human 8.8 pKi = 8.8 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 512 11 2 6 4.8 Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(C(=O)O)cc2)(c2ccccc2)c2ccccc2)n1 10.1021/jm9910425
11113812 200940 0 None 1258 2 Human 8.8 pKi = 8.8 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 497 7 1 6 6.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2/C=C\c2ccccc2)c1C 10.1021/jm020289q
CHEMBL29313 200940 0 None 1258 2 Human 8.8 pKi = 8.8 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 497 7 1 6 6.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2/C=C\c2ccccc2)c1C 10.1021/jm020289q
CHEMBL1790180 484793 0 None -72 3 Rat 8.8 pKi = 8.8 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumCompound was evaluated for the binding affinity to Endothelin A receptor in the rat atrium
ChEMBL 2655 50 34 37 -2.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCc3ccc(O)cc3)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00087a001
44311810 203080 5 None -6 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00387-4
44312023 203080 5 None -6 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00387-4
9830098 203080 5 None -6 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00387-4
9938533 203080 5 None -6 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00387-4
CHEMBL307033 203080 5 None -6 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00387-4
CHEMBL310919 203080 5 None -6 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00387-4
CHEMBL311854 203080 5 None -6 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00387-4
CHEMBL72295 203080 5 None -6 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00387-4
9895957 24953 18 None 5 2 Human 8.7 pKi = 8.7 Binding
Binding affinity at endothelin receptor subtype ABinding affinity at endothelin receptor subtype A
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1016/j.bmc.2012.06.011
CHEMBL11706 24953 18 None 5 2 Human 8.7 pKi = 8.7 Binding
Binding affinity at endothelin receptor subtype ABinding affinity at endothelin receptor subtype A
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1016/j.bmc.2012.06.011
44311728 214071 0 None -13 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 653 12 3 7 4.4 C=CS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL310039 214071 0 None -13 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 653 12 3 7 4.4 C=CS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
9895957 24953 18 None 5 2 Human 8.7 pKi = 8.7 Binding
Compound was evaluated for its binding affinity towards human Endothelin A receptorCompound was evaluated for its binding affinity towards human Endothelin A receptor
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1021/jm020138n
CHEMBL11706 24953 18 None 5 2 Human 8.7 pKi = 8.7 Binding
Compound was evaluated for its binding affinity towards human Endothelin A receptorCompound was evaluated for its binding affinity towards human Endothelin A receptor
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1021/jm020138n
9895957 24953 18 None 5 2 Human 8.7 pKi = 8.7 Binding
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1021/jm058225d
CHEMBL11706 24953 18 None 5 2 Human 8.7 pKi = 8.7 Binding
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1021/jm058225d
10555112 19077 0 None 12 2 Human 8.7 pKi = 8.7 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 572 14 2 8 4.6 COc1cc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)ccc1OCC(=O)O 10.1021/jm9910425
CHEMBL103695 19077 0 None 12 2 Human 8.7 pKi = 8.7 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 572 14 2 8 4.6 COc1cc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)ccc1OCC(=O)O 10.1021/jm9910425
11799974 18877 0 None 12 2 Human 8.7 pKi = 8.7 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 514 12 1 7 4.8 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(OC)n2)C(=O)O)cc1 10.1021/jm9910425
CHEMBL102307 18877 0 None 12 2 Human 8.7 pKi = 8.7 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 514 12 1 7 4.8 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(OC)n2)C(=O)O)cc1 10.1021/jm9910425
44311805 469464 0 None -26 2 Human 8.0 pKi = 8 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 669 12 3 7 4.7 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NS(=O)(=O)C(C)C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL73000 469464 0 None -26 2 Human 8.0 pKi = 8 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 669 12 3 7 4.7 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NS(=O)(=O)C(C)C)c1 10.1016/s0960-894x(98)00387-4
13015 3149 30 None None None Human 8.0 pKi = 8 Binding
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 536 8 1 7 5.8 CC1=C(ON=C1NS(=O)(=O)C2=CC=CC=C2C3=C(C=C(C=C3)C4=NC=CO4)CN(C)C(=O)CC(C)(C)C)C 10.1021/jm058225d
156690 3149 30 None None None Human 8.0 pKi = 8 Binding
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 536 8 1 7 5.8 CC1=C(ON=C1NS(=O)(=O)C2=CC=CC=C2C3=C(C=C(C=C3)C4=NC=CO4)CN(C)C(=O)CC(C)(C)C)C 10.1021/jm058225d
CHEMBL383581 3149 30 None None None Human 8.0 pKi = 8 Binding
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 536 8 1 7 5.8 CC1=C(ON=C1NS(=O)(=O)C2=CC=CC=C2C3=C(C=C(C=C3)C4=NC=CO4)CN(C)C(=O)CC(C)(C)C)C 10.1021/jm058225d
10812403 82550 0 None 120 2 Rat 7.0 pKi = 7 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 427 7 2 5 4.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2C(N)=O)c1C 10.1021/jm970872k
CHEMBL146904 82550 0 None 120 2 Rat 7.0 pKi = 7 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 427 7 2 5 4.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2C(N)=O)c1C 10.1021/jm970872k
10573784 330223 0 None 95 2 Rat 7.0 pKi = 7 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 413 7 2 5 4.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2CN)c1C 10.1021/jm970872k
CHEMBL423583 330223 0 None 95 2 Rat 7.0 pKi = 7 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 413 7 2 5 4.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2CN)c1C 10.1021/jm970872k
1481 7955 73 None -8317 2 Human 5.0 pKi = 5 Binding
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm300682j
3749 7955 73 None -8317 2 Human 5.0 pKi = 5 Binding
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm300682j
6908 7955 73 None -8317 2 Human 5.0 pKi = 5 Binding
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm300682j
CHEMBL1513 7955 73 None -8317 2 Human 5.0 pKi = 5 Binding
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/jm300682j
10619232 240583 0 None None None Rat 7.0 pKi = 7.0 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 371 5 1 5 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2N(C)C)c1C 10.1021/jm970872k
CHEMBL359332 240583 0 None None None Rat 7.0 pKi = 7.0 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 371 5 1 5 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2N(C)C)c1C 10.1021/jm970872k
44267891 42619 0 None None None Human 7.0 pKi = 7.0 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 532 8 1 7 5.9 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
CHEMBL12779 42619 0 None None None Human 7.0 pKi = 7.0 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 532 8 1 7 5.9 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
44333366 217047 0 None -1 2 Human 7.0 pKi = 7.0 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 570 12 1 8 5.2 COc1ccc(CCOC(c2ccc(C)cc2)(c2ccc(C)cc2)C(Oc2nc3c(c(OC)n2)COC3)C(=O)O)cc1 10.1021/jm9910425
CHEMBL318146 217047 0 None -1 2 Human 7.0 pKi = 7.0 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 570 12 1 8 5.2 COc1ccc(CCOC(c2ccc(C)cc2)(c2ccc(C)cc2)C(Oc2nc3c(c(OC)n2)COC3)C(=O)O)cc1 10.1021/jm9910425
10742005 468690 0 None 162 2 Human 8.0 pKi = 8.0 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 446 9 1 7 3.2 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2cccc(F)c2)c2cccc(F)c2)n1 10.1021/jm960274q
CHEMBL67536 468690 0 None 162 2 Human 8.0 pKi = 8.0 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 446 9 1 7 3.2 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2cccc(F)c2)c2cccc(F)c2)n1 10.1021/jm960274q
10740258 219241 0 None 1096 2 Human 8.0 pKi = 8.0 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 409 5 1 6 4.7 Cc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)o1 10.1021/jm000105c
CHEMBL322674 219241 0 None 1096 2 Human 8.0 pKi = 8.0 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 409 5 1 6 4.7 Cc1cnc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)o1 10.1021/jm000105c
10321341 292168 0 None 93 2 Human 8.0 pKi = 8.0 Binding
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 446 7 1 5 5.2 CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1021/jm00037a003
CHEMBL39142 292168 0 None 93 2 Human 8.0 pKi = 8.0 Binding
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 446 7 1 5 5.2 CCCOc1ccc2c(c1)[C@@H](c1ccc(OC)cc1)[C@H](C(=O)O)[C@H]2c1ccc2c(c1)OCO2 10.1021/jm00037a003
10598958 84855 0 None None None Rat 7.0 pKi = 7.0 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 434 6 1 6 3.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(S(=O)(=O)C(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL149050 84855 0 None None None Rat 7.0 pKi = 7.0 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 434 6 1 6 3.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(S(=O)(=O)C(C)C)cc2)c1C 10.1021/jm970872k
10715881 240144 0 None 37 2 Rat 7.0 pKi = 7.0 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 398 5 1 4 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL358545 240144 0 None 37 2 Rat 7.0 pKi = 7.0 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 398 5 1 4 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)(C)C)cc2)c1C 10.1021/jm970872k
9848710 333698 4 None -301 4 Pig 5.0 pKi = 5.0 Binding
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 497 9 3 3 4.3 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/0960-894X(96)00421-0
CHEMBL439759 333698 4 None -301 4 Pig 5.0 pKi = 5.0 Binding
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 497 9 3 3 4.3 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/0960-894X(96)00421-0
9848710 333698 4 None -301 4 Human 5.0 pKi = 5.0 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 497 9 3 3 4.3 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
CHEMBL439759 333698 4 None -301 4 Human 5.0 pKi = 5.0 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 497 9 3 3 4.3 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
10761748 239646 0 None None None Rat 7.0 pKi = 7.0 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 371 5 1 5 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2cccc(N(C)C)c2)c1C 10.1021/jm970872k
CHEMBL356591 239646 0 None None None Rat 7.0 pKi = 7.0 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 371 5 1 5 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2cccc(N(C)C)c2)c1C 10.1021/jm970872k
44286764 292535 0 None None None Human 5.0 pKi = 5.0 Binding
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 314 3 1 1 4.7 O=C(O)[C@@H]1[C@@H](c2ccccc2)c2ccccc2[C@H]1c1ccccc1 10.1021/jm00037a003
CHEMBL39171 292535 0 None None None Human 5.0 pKi = 5.0 Binding
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 314 3 1 1 4.7 O=C(O)[C@@H]1[C@@H](c2ccccc2)c2ccccc2[C@H]1c1ccccc1 10.1021/jm00037a003
10503999 84738 0 None 6 2 Rat 5.9 pKi = 5.9 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 456 8 3 6 3.9 Cc1noc(NS(=O)(=O)c2ccc(NC(=O)CN)cc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL148953 84738 0 None 6 2 Rat 5.9 pKi = 5.9 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 456 8 3 6 3.9 Cc1noc(NS(=O)(=O)c2ccc(NC(=O)CN)cc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
10762600 333009 0 None 154 2 Rat 7.9 pKi = 7.9 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 384 6 1 4 5.0 Cc1onc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL434082 333009 0 None 154 2 Rat 7.9 pKi = 7.9 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 384 6 1 4 5.0 Cc1onc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
10209324 38400 0 None None None Human 7.9 pKi = 7.9 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 546 8 1 7 6.2 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
CHEMBL12013 38400 0 None None None Human 7.9 pKi = 7.9 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 546 8 1 7 6.2 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(C)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
3539 8957 55 None None None Human 7.9 pKi = 7.9 Binding
Displacement of 125[I]-ET-1 from human ETADisplacement of 125[I]-ET-1 from human ETA
ChEMBL 424 6 1 9 2.7 COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 10.1021/acsmedchemlett.4c00431
9910224 8957 55 None None None Human 7.9 pKi = 7.9 Binding
Displacement of 125[I]-ET-1 from human ETADisplacement of 125[I]-ET-1 from human ETA
ChEMBL 424 6 1 9 2.7 COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 10.1021/acsmedchemlett.4c00431
CHEMBL1628688 8957 55 None None None Human 7.9 pKi = 7.9 Binding
Displacement of 125[I]-ET-1 from human ETADisplacement of 125[I]-ET-1 from human ETA
ChEMBL 424 6 1 9 2.7 COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 10.1021/acsmedchemlett.4c00431
DB06629 8957 55 None None None Human 7.9 pKi = 7.9 Binding
Displacement of 125[I]-ET-1 from human ETADisplacement of 125[I]-ET-1 from human ETA
ChEMBL 424 6 1 9 2.7 COc1nc(C)cnc1NS(=O)(=O)c1cccnc1c1ccc(cc1)c1nnco1 10.1021/acsmedchemlett.4c00431
44311851 469554 0 None -162 2 Human 6.9 pKi = 6.9 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 564 10 3 5 4.9 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccon3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
CHEMBL73697 469554 0 None -162 2 Human 6.9 pKi = 6.9 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 564 10 3 5 4.9 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccon3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
10692125 468112 0 None 26 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 396 8 2 7 2.3 COc1cc(OC)nc(OC(C(=O)O)C(O)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
CHEMBL63648 468112 0 None 26 2 Human 6.9 pKi = 6.9 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 396 8 2 7 2.3 COc1cc(OC)nc(OC(C(=O)O)C(O)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
44314607 316813 0 None -1412 2 Pig 5.9 pKi = 5.9 Binding
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1534 46 19 18 -0.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
77282208 316813 0 None -1412 2 Pig 5.9 pKi = 5.9 Binding
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1534 46 19 18 -0.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
CHEMBL412003 316813 0 None -1412 2 Pig 5.9 pKi = 5.9 Binding
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1534 46 19 18 -0.2 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
10620897 85038 0 None 14 2 Rat 5.9 pKi = 5.9 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 398 6 1 4 5.3 Cc1cccc(-c2ccc(CC(C)C)cc2)c1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
CHEMBL149171 85038 0 None 14 2 Rat 5.9 pKi = 5.9 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 398 6 1 4 5.3 Cc1cccc(-c2ccc(CC(C)C)cc2)c1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
CHEMBL4513786 477449 5 None -2344 8 Human 4.9 pKi = 4.9 Binding
Affinity Biochemical interaction ([125I]-endothelin-1 saturation binding assay) EUB0000289bCl EDNRAAffinity Biochemical interaction ([125I]-endothelin-1 saturation binding assay) EUB0000289bCl EDNRA
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@@H](c2cc(OC)c3c(c2)OCO3)[C@H](C(=O)O)[C@H]1CC(C)(C)CCC 10.6019/CHEMBL5210307
CHEMBL4796803 477449 5 None -2344 8 Human 4.9 pKi = 4.9 Binding
Affinity Biochemical interaction ([125I]-endothelin-1 saturation binding assay) EUB0000289bCl EDNRAAffinity Biochemical interaction ([125I]-endothelin-1 saturation binding assay) EUB0000289bCl EDNRA
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@@H](c2cc(OC)c3c(c2)OCO3)[C@H](C(=O)O)[C@H]1CC(C)(C)CCC 10.6019/CHEMBL5210307
CHEMBL4513786 477449 5 None -2344 8 Human 4.9 pKi = 4.9 Binding
[125I]-endothelin-1 saturation binding[125I]-endothelin-1 saturation binding
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@@H](c2cc(OC)c3c(c2)OCO3)[C@H](C(=O)O)[C@H]1CC(C)(C)CCC 10.6019/CHEMBL4507258
CHEMBL4796803 477449 5 None -2344 8 Human 4.9 pKi = 4.9 Binding
[125I]-endothelin-1 saturation binding[125I]-endothelin-1 saturation binding
ChEMBL 532 15 1 6 5.5 CCCCN(CCCC)C(=O)CN1C[C@@H](c2cc(OC)c3c(c2)OCO3)[C@H](C(=O)O)[C@H]1CC(C)(C)CCC 10.6019/CHEMBL4507258
2529 347569 76 None None None Human 4.9 pKi = 4.9 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C nan
5344 347569 76 None None None Human 4.9 pKi = 4.9 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C nan
CHEMBL453 347569 76 None None None Human 4.9 pKi = 4.9 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C nan
DB00263 347569 76 None None None Human 4.9 pKi = 4.9 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C nan
10740469 82754 0 None 154 2 Rat 7.9 pKi = 7.9 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 413 7 2 5 5.0 CNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
CHEMBL147081 82754 0 None 154 2 Rat 7.9 pKi = 7.9 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 413 7 2 5 5.0 CNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
10668636 240562 0 None 147 2 Rat 7.9 pKi = 7.9 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 399 6 2 5 4.5 Cc1noc(NS(=O)(=O)c2ccc(N)cc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL359167 240562 0 None 147 2 Rat 7.9 pKi = 7.9 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 399 6 2 5 4.5 Cc1noc(NS(=O)(=O)c2ccc(N)cc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
10166561 24365 0 None None None Human 7.9 pKi = 7.9 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 562 9 2 8 5.4 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CO)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
CHEMBL11528 24365 0 None None None Human 7.9 pKi = 7.9 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 562 9 2 8 5.4 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CO)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
10809354 239745 1 None None None Rat 6.9 pKi = 6.9 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 373 5 1 6 3.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2[N+](=O)[O-])c1C 10.1021/jm970872k
CHEMBL357580 239745 1 None None None Rat 6.9 pKi = 6.9 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 373 5 1 6 3.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2[N+](=O)[O-])c1C 10.1021/jm970872k
19934544 473185 0 None -2 2 Human 4.9 pKi = 4.9 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 482 7 3 4 4.9 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NC(=O)Cc3c[nH]c4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
CHEMBL86489 473185 0 None -2 2 Human 4.9 pKi = 4.9 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 482 7 3 4 4.9 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NC(=O)Cc3c[nH]c4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
44267862 39254 0 None None None Human 7.8 pKi = 7.8 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 571 9 1 8 5.9 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CC#N)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
CHEMBL12144 39254 0 None None None Human 7.8 pKi = 7.8 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 571 9 1 8 5.9 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(CC#N)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
10453858 315868 0 None 31 2 Human 7.8 pKi = 7.8 Binding
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 404 4 2 5 4.1 COc1ccc([C@@H]2c3cc(O)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1021/jm00037a003
CHEMBL41087 315868 0 None 31 2 Human 7.8 pKi = 7.8 Binding
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 404 4 2 5 4.1 COc1ccc([C@@H]2c3cc(O)ccc3[C@H](c3ccc4c(c3)OCO4)[C@H]2C(=O)O)cc1 10.1021/jm00037a003
10837085 202394 0 None 39 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 446 9 1 7 3.2 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccccc2F)c2ccccc2F)n1 10.1021/jm960274q
CHEMBL303501 202394 0 None 39 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 446 9 1 7 3.2 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccccc2F)c2ccccc2F)n1 10.1021/jm960274q
10670204 84955 0 None 17 2 Rat 5.8 pKi = 5.8 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 428 7 2 5 4.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2C(=O)O)c1C 10.1021/jm970872k
CHEMBL149111 84955 0 None 17 2 Rat 5.8 pKi = 5.8 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 428 7 2 5 4.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2C(=O)O)c1C 10.1021/jm970872k
10603135 219303 0 None 1 2 Human 6.8 pKi = 6.8 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 570 14 1 7 6.0 CCc1ccc(C(OCCc2ccc(OC)cc2)(c2ccc(CC)cc2)C(Oc2nc(C)cc(OC)n2)C(=O)O)cc1 10.1021/jm9910425
CHEMBL322996 219303 0 None 1 2 Human 6.8 pKi = 6.8 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 570 14 1 7 6.0 CCc1ccc(C(OCCc2ccc(OC)cc2)(c2ccc(CC)cc2)C(Oc2nc(C)cc(OC)n2)C(=O)O)cc1 10.1021/jm9910425
10521320 238483 0 None None None Rat 7.8 pKi = 7.8 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 343 4 2 5 3.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2N)c1C 10.1021/jm970872k
CHEMBL347958 238483 0 None None None Rat 7.8 pKi = 7.8 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 343 4 2 5 3.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2N)c1C 10.1021/jm970872k
10549727 329803 0 None 125 2 Rat 7.8 pKi = 7.8 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 414 7 1 5 5.0 COc1cccc(S(=O)(=O)Nc2onc(C)c2C)c1-c1ccc(CC(C)C)cc1 10.1021/jm970872k
CHEMBL422128 329803 0 None 125 2 Rat 7.8 pKi = 7.8 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 414 7 1 5 5.0 COc1cccc(S(=O)(=O)Nc2onc(C)c2C)c1-c1ccc(CC(C)C)cc1 10.1021/jm970872k
44267893 198689 0 None None None Human 7.8 pKi = 7.8 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 535 10 2 7 4.9 CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
CHEMBL275523 198689 0 None None None Human 7.8 pKi = 7.8 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 535 10 2 7 4.9 CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
10740953 19652 0 None 758 2 Human 7.8 pKi = 7.8 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 423 5 1 6 5.0 Cc1nc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)oc1C 10.1021/jm000105c
CHEMBL106749 19652 0 None 758 2 Human 7.8 pKi = 7.8 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 423 5 1 6 5.0 Cc1nc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)oc1C 10.1021/jm000105c
44274885 194501 0 None 29 2 Human 6.8 pKi = 6.8 Binding
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 454 10 1 7 4.5 COc1cc(OC)nc(CC(C(=O)O)C(C)(Oc2ccc(SC)cc2)c2ccccc2)n1 10.1021/jm030480f
CHEMBL24906 194501 0 None 29 2 Human 6.8 pKi = 6.8 Binding
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 454 10 1 7 4.5 COc1cc(OC)nc(CC(C(=O)O)C(C)(Oc2ccc(SC)cc2)c2ccccc2)n1 10.1021/jm030480f
44307287 468747 0 None 29 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 470 10 0 9 4.1 COC(=O)C(Oc1nc(OC)cc(OC)n1)C(C)(Oc1ccc(SC)cc1)c1ccccc1 10.1021/jm960274q
CHEMBL67957 468747 0 None 29 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 470 10 0 9 4.1 COC(=O)C(Oc1nc(OC)cc(OC)n1)C(C)(Oc1ccc(SC)cc1)c1ccccc1 10.1021/jm960274q
176 823 54 None -7 31 Human 4.8 pKi = 4.8 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2157 823 54 None -7 31 Human 4.8 pKi = 4.8 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2566 823 54 None -7 31 Human 4.8 pKi = 4.8 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
CHEMBL633 823 54 None -7 31 Human 4.8 pKi = 4.8 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
DB01118 823 54 None -7 31 Human 4.8 pKi = 4.8 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
10620185 238382 0 None 89 2 Rat 7.8 pKi = 7.8 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 386 6 1 5 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(OC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL346853 238382 0 None 89 2 Rat 7.8 pKi = 7.8 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 386 6 1 5 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(OC(C)C)cc2)c1C 10.1021/jm970872k
10741144 238487 0 None 407 2 Rat 7.8 pKi = 7.8 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 427 8 2 5 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NC=O)c1C 10.1021/jm970872k
CHEMBL347982 238487 0 None 407 2 Rat 7.8 pKi = 7.8 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 427 8 2 5 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NC=O)c1C 10.1021/jm970872k
17979733 197556 0 None None None Human 7.8 pKi = 7.8 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 576 10 1 8 6.0 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(COC)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
CHEMBL268706 197556 0 None None None Human 7.8 pKi = 7.8 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 576 10 1 8 6.0 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(COC)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
44303033 468253 0 None None None Human 6.8 pKi = 6.8 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 472 6 1 5 5.4 COc1ccc(CC2C(c3ccc(Cl)c(Cl)c3)C(=O)O[C@@]2(O)c2ccc(OC)cc2)cc1 10.1021/jm990504b
CHEMBL64424 468253 0 None None None Human 6.8 pKi = 6.8 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 472 6 1 5 5.4 COc1ccc(CC2C(c3ccc(Cl)c(Cl)c3)C(=O)O[C@@]2(O)c2ccc(OC)cc2)cc1 10.1021/jm990504b
9934204 216601 0 None -1 2 Human 4.8 pKi = 4.8 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 465 7 2 4 6.0 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NCc3cccc4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
CHEMBL314915 216601 0 None -1 2 Human 4.8 pKi = 4.8 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 465 7 2 4 6.0 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NCc3cccc4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
10836754 468594 0 None 14 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 438 11 1 7 3.7 CCOc1cc(OCC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
CHEMBL66893 468594 0 None 14 2 Human 6.8 pKi = 6.8 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 438 11 1 7 3.7 CCOc1cc(OCC)nc(OC(C(=O)O)C(OC)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
10691437 19421 0 None -1 4 Rat 7.8 pKi = 7.8 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 384 6 1 4 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL105490 19421 0 None -1 4 Rat 7.8 pKi = 7.8 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 384 6 1 4 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
101039204 1466 45 None 2 3 Human 7.8 pKi = 7.8 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/0960-894X(95)00019-P
443289 1466 45 None 2 3 Human 7.8 pKi = 7.8 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/0960-894X(95)00019-P
997 1466 45 None 2 3 Human 7.8 pKi = 7.8 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/0960-894X(95)00019-P
CHEMBL314691 1466 45 None 2 3 Human 7.8 pKi = 7.8 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/0960-894X(95)00019-P
CHEMBL4095638 1466 45 None 2 3 Human 7.8 pKi = 7.8 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/0960-894X(95)00019-P
DB12054 1466 45 None 2 3 Human 7.8 pKi = 7.8 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1016/0960-894X(95)00019-P
10691437 19421 0 None 1 4 Human 7.8 pKi = 7.8 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 384 6 1 4 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm000105c
CHEMBL105490 19421 0 None 1 4 Human 7.8 pKi = 7.8 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 384 6 1 4 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm000105c
CHEMBL1201469 38416 0 None -1 4 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL None None None None nan
22103797 84801 0 None None None Human 7.7 pKi = 7.7 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 408 5 1 6 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nccn3C)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL149010 84801 0 None None None Human 7.7 pKi = 7.7 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 408 5 1 6 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nccn3C)cc2)c1C 10.1016/s0960-894x(01)00791-0
5122650 202981 2 None 100 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 364 7 1 5 3.2 COC(c1ccccc1)(c1ccccc1)C(Oc1nccc(C)n1)C(=O)O 10.1021/jm960274q
CHEMBL306218 202981 2 None 100 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 364 7 1 5 3.2 COC(c1ccccc1)(c1ccccc1)C(Oc1nccc(C)n1)C(=O)O 10.1021/jm960274q
11797288 468617 0 None 89 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 438 11 1 7 3.7 CCCOC(c1ccccc1)(c1ccccc1)C(Oc1nc(OC)cc(OC)n1)C(=O)O 10.1021/jm960274q
CHEMBL67084 468617 0 None 89 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 438 11 1 7 3.7 CCCOC(c1ccccc1)(c1ccccc1)C(Oc1nc(OC)cc(OC)n1)C(=O)O 10.1021/jm960274q
10669224 218073 0 None 1778 2 Human 7.7 pKi = 7.7 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 409 6 1 6 4.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cc3ncco3)cc2)c1C 10.1021/jm000105c
CHEMBL319924 218073 0 None 1778 2 Human 7.7 pKi = 7.7 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 409 6 1 6 4.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(Cc3ncco3)cc2)c1C 10.1021/jm000105c
10673091 328310 0 None 4 2 Human 7.7 pKi = 7.7 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 502 10 1 5 5.8 Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(Cl)cc2)(c2ccccc2)c2ccccc2)n1 10.1021/jm9910425
CHEMBL418992 328310 0 None 4 2 Human 7.7 pKi = 7.7 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 502 10 1 5 5.8 Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(Cl)cc2)(c2ccccc2)c2ccccc2)n1 10.1021/jm9910425
10836583 83134 0 None 43 2 Rat 6.7 pKi = 6.7 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 434 7 1 5 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(OCc3ccccc3)cc2)c1C 10.1021/jm970872k
CHEMBL147521 83134 0 None 43 2 Rat 6.7 pKi = 6.7 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 434 7 1 5 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(OCc3ccccc3)cc2)c1C 10.1021/jm970872k
10643748 240042 0 None 29 2 Rat 6.7 pKi = 6.7 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 384 6 1 4 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2cccc(CC(C)C)c2)c1C 10.1021/jm970872k
CHEMBL358226 240042 0 None 29 2 Rat 6.7 pKi = 6.7 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 384 6 1 4 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2cccc(CC(C)C)c2)c1C 10.1021/jm970872k
10813050 97346 0 None 602 2 Rat 8.7 pKi = 8.7 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 441 9 2 5 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2CNC=O)c1C 10.1021/jm970872k
CHEMBL151440 97346 0 None 602 2 Rat 8.7 pKi = 8.7 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 441 9 2 5 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2CNC=O)c1C 10.1021/jm970872k
9895957 24953 18 None 5 2 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1016/s0960-894x(03)00018-0
CHEMBL11706 24953 18 None 5 2 Human 8.7 pKi = 8.7 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 659 11 1 7 6.8 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CN2CCC(C)(C)C2=O)c1 10.1016/s0960-894x(03)00018-0
10835335 19176 0 None 50118 2 Human 8.7 pKi = 8.7 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 409 5 1 6 4.7 Cc1coc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)n1 10.1021/jm000105c
CHEMBL104223 19176 0 None 50118 2 Human 8.7 pKi = 8.7 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 409 5 1 6 4.7 Cc1coc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)n1 10.1021/jm000105c
11799973 18780 0 None 31 2 Human 8.7 pKi = 8.7 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 514 11 1 7 5.1 COc1ccc(COC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
CHEMBL101587 18780 0 None 31 2 Human 8.7 pKi = 8.7 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 514 11 1 7 5.1 COc1ccc(COC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
6433100 18895 17 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counting method
ChEMBL 528 12 1 7 5.1 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/acs.jmedchem.5b01781
9893800 18895 17 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counting method
ChEMBL 528 12 1 7 5.1 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/acs.jmedchem.5b01781
CHEMBL102405 18895 17 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counting method
ChEMBL 528 12 1 7 5.1 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/acs.jmedchem.5b01781
CHEMBL316735 18895 17 None 2 2 Human 8.7 pKi = 8.7 Binding
Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counting methodDisplacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane incubated for 30 mins by liquid scintillation counting method
ChEMBL 528 12 1 7 5.1 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/acs.jmedchem.5b01781
6433100 18895 17 None 2 2 Human 8.7 pKi = 8.7 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 528 12 1 7 5.1 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
9893800 18895 17 None 2 2 Human 8.7 pKi = 8.7 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 528 12 1 7 5.1 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
CHEMBL102405 18895 17 None 2 2 Human 8.7 pKi = 8.7 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 528 12 1 7 5.1 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
CHEMBL316735 18895 17 None 2 2 Human 8.7 pKi = 8.7 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 528 12 1 7 5.1 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
44311727 469371 0 None -9 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 669 13 3 7 4.7 CCCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL72348 469371 0 None -9 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 669 13 3 7 4.7 CCCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
22467266 176293 0 None 691 2 Human 8.7 pKi = 8.7 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 522 7 2 8 3.4 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 10.1007/s00044-004-0021-y
76312118 176293 0 None 691 2 Human 8.7 pKi = 8.7 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 522 7 2 8 3.4 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261360 176293 0 None 691 2 Human 8.7 pKi = 8.7 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 522 7 2 8 3.4 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261361 176293 0 None 691 2 Human 8.7 pKi = 8.7 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 522 7 2 8 3.4 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(CO)ccc12 10.1007/s00044-004-0021-y
18660521 85120 0 None 2754 2 Human 8.6 pKi = 8.6 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 405 5 1 5 4.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccccn3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL149232 85120 0 None 2754 2 Human 8.6 pKi = 8.6 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 405 5 1 5 4.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccccn3)cc2)c1C 10.1016/s0960-894x(01)00791-0
44311915 214500 0 None -6 2 Human 8.6 pKi = 8.6 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 703 12 3 7 5.4 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NS(=O)(=O)c2ccccc2)c1 10.1016/s0960-894x(98)00387-4
CHEMBL310920 214500 0 None -6 2 Human 8.6 pKi = 8.6 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 703 12 3 7 5.4 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NS(=O)(=O)c2ccccc2)c1 10.1016/s0960-894x(98)00387-4
10768897 217290 1 None 6 2 Human 8.6 pKi = 8.6 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 544 13 1 8 4.8 COc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(OC)c(OC)c2)(c2ccccc2)c2ccccc2)n1 10.1021/jm9910425
CHEMBL319031 217290 1 None 6 2 Human 8.6 pKi = 8.6 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 544 13 1 8 4.8 COc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(OC)c(OC)c2)(c2ccccc2)c2ccccc2)n1 10.1021/jm9910425
51003307 120856 0 None 3548 2 Mouse 8.6 pKi = 8.6 Binding
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 751 21 1 15 4.0 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCc3cn(CCOCCOCCOCCF)nn3)c2)cc1 10.1021/jm101110w
CHEMBL1672881 120856 0 None 3548 2 Mouse 8.6 pKi = 8.6 Binding
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 751 21 1 15 4.0 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCc3cn(CCOCCOCCOCCF)nn3)c2)cc1 10.1021/jm101110w
45257115 462729 0 None 39 2 Mouse 8.6 pKi = 8.6 Binding
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 538 10 1 9 4.2 COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OCCF)cc2)cc(OC)c1OC 10.1016/j.bmc.2009.08.058
CHEMBL604286 462729 0 None 39 2 Mouse 8.6 pKi = 8.6 Binding
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 538 10 1 9 4.2 COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OCCF)cc2)cc(OC)c1OC 10.1016/j.bmc.2009.08.058
CHEMBL1790180 484793 0 None -72 3 Rat 8.6 pKi = 8.6 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat aortaCompound was evaluated for the binding affinity to Endothelin A receptor in the rat aorta
ChEMBL 2655 50 34 37 -2.3 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@@H](N)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CCc3ccc(O)cc3)NC(=O)[C@H]([C@H](C)O)NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1021/jm00087a001
11049336 200120 0 None 3630 2 Human 8.6 pKi = 8.6 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 497 7 1 6 6.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2/C=C/c2ccccc2)c1C 10.1021/jm020289q
CHEMBL286279 200120 0 None 3630 2 Human 8.6 pKi = 8.6 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 497 7 1 6 6.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2/C=C/c2ccccc2)c1C 10.1021/jm020289q
10670965 85744 0 None 851 2 Rat 8.6 pKi = 8.6 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 444 9 2 6 4.3 Cc1noc(NS(=O)(=O)c2cccc(OCCO)c2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL149819 85744 0 None 851 2 Rat 8.6 pKi = 8.6 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 444 9 2 6 4.3 Cc1noc(NS(=O)(=O)c2cccc(OCCO)c2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
44311804 203068 0 None -12 2 Human 8.5 pKi = 8.5 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 683 14 3 7 5.1 CCCCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL306950 203068 0 None -12 2 Human 8.5 pKi = 8.5 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 683 14 3 7 5.1 CCCCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
10501931 97174 0 None 64 2 Rat 7.7 pKi = 7.7 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 414 7 2 5 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2CO)c1C 10.1021/jm970872k
CHEMBL151160 97174 0 None 64 2 Rat 7.7 pKi = 7.7 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 414 7 2 5 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2CO)c1C 10.1021/jm970872k
10668819 239726 0 None 602 2 Rat 7.7 pKi = 7.7 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 402 6 1 4 5.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2F)c1C 10.1021/jm970872k
CHEMBL357395 239726 0 None 602 2 Rat 7.7 pKi = 7.7 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 402 6 1 4 5.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2F)c1C 10.1021/jm970872k
22574798 39413 0 None None None Human 7.7 pKi = 7.7 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 579 13 2 8 5.2 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COCC)c1 10.1016/s0960-894x(03)00018-0
CHEMBL12175 39413 0 None None None Human 7.7 pKi = 7.7 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 579 13 2 8 5.2 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COCC)c1 10.1016/s0960-894x(03)00018-0
17979749 41715 0 None None None Human 7.7 pKi = 7.7 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 550 8 1 7 6.0 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(F)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
CHEMBL12590 41715 0 None None None Human 7.7 pKi = 7.7 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 550 8 1 7 6.0 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(F)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
44267860 331921 0 None None None Human 7.7 pKi = 7.7 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 590 11 1 8 6.4 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(COCC)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
CHEMBL429037 331921 0 None None None Human 7.7 pKi = 7.7 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 590 11 1 8 6.4 CCCc1nc2c(n1Cc1ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)c(COCC)c1)C(=O)CCCC2 10.1016/s0960-894x(03)00018-0
10599129 202324 0 None 5 2 Human 6.7 pKi = 6.7 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 438 9 1 7 3.5 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccc(C)cc2)c2ccc(C)cc2)n1 10.1021/jm960274q
CHEMBL303034 202324 0 None 5 2 Human 6.7 pKi = 6.7 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 438 9 1 7 3.5 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccc(C)cc2)c2ccc(C)cc2)n1 10.1021/jm960274q
44314882 313084 0 None -380 2 Pig 5.7 pKi = 5.7 Binding
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1562 47 19 18 0.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
77282212 313084 0 None -380 2 Pig 5.7 pKi = 5.7 Binding
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1562 47 19 18 0.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
CHEMBL407559 313084 0 None -380 2 Pig 5.7 pKi = 5.7 Binding
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1562 47 19 18 0.4 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
10813228 217293 0 None 46 2 Human 5.7 pKi = 5.7 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 445 5 1 6 5.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nc4ccccc4o3)cc2)c1C 10.1021/jm000105c
CHEMBL319036 217293 0 None 46 2 Human 5.7 pKi = 5.7 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 445 5 1 6 5.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nc4ccccc4o3)cc2)c1C 10.1021/jm000105c
10545378 82666 0 None None None Rat 5.7 pKi = 5.7 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 344 5 1 5 3.9 Cc1noc(NS(=O)(=O)c2ccccc2Oc2ccccc2)c1C 10.1021/jm970872k
CHEMBL147007 82666 0 None None None Rat 5.7 pKi = 5.7 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 344 5 1 5 3.9 Cc1noc(NS(=O)(=O)c2ccccc2Oc2ccccc2)c1C 10.1021/jm970872k
20747573 41026 0 None None None Human 7.7 pKi = 7.7 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 593 13 2 8 5.4 CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COCC)c1 10.1016/s0960-894x(03)00018-0
CHEMBL12557 41026 0 None None None Human 7.7 pKi = 7.7 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 593 13 2 8 5.4 CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COCC)c1 10.1016/s0960-894x(03)00018-0
10719157 202381 0 None 58 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 470 11 1 9 2.9 COc1cccc(C(OC)(c2cccc(OC)c2)C(Oc2nc(OC)cc(OC)n2)C(=O)O)c1 10.1021/jm960274q
CHEMBL303390 202381 0 None 58 2 Human 7.7 pKi = 7.7 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 470 11 1 9 2.9 COc1cccc(C(OC)(c2cccc(OC)c2)C(Oc2nc(OC)cc(OC)n2)C(=O)O)c1 10.1021/jm960274q
19085508 83030 0 None 218 2 Human 6.7 pKi = 6.7 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 466 7 1 8 4.2 COc1cc(OC)nc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)n1 10.1016/s0960-894x(01)00791-0
CHEMBL147365 83030 0 None 218 2 Human 6.7 pKi = 6.7 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 466 7 1 8 4.2 COc1cc(OC)nc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)n1 10.1016/s0960-894x(01)00791-0
CHEMBL315927 486605 0 None None None Human 6.7 pKi = 6.7 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 621 7 5 6 1.5 CC(C)C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2cccc3ccccc23)NC1=O 10.1016/0960-894X(95)00019-P
10505434 19009 0 None 7 2 Human 7.6 pKi = 7.6 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 496 11 1 5 5.8 Cc1ccc(CCCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 10.1021/jm9910425
CHEMBL103190 19009 0 None 7 2 Human 7.6 pKi = 7.6 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 496 11 1 5 5.8 Cc1ccc(CCCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 10.1021/jm9910425
11801906 198792 0 None -1 2 Human 6.6 pKi = 6.6 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 612 13 1 8 6.2 COc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(OC)c(OC)c2)(c2ccc(Cl)cc2)c2ccc(Cl)cc2)n1 10.1021/jm9910425
CHEMBL276288 198792 0 None -1 2 Human 6.6 pKi = 6.6 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 612 13 1 8 6.2 COc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(OC)c(OC)c2)(c2ccc(Cl)cc2)c2ccc(Cl)cc2)n1 10.1021/jm9910425
44311698 469053 0 None -524 2 Human 5.6 pKi = 5.6 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 574 10 3 4 5.3 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccccn3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
CHEMBL70310 469053 0 None -524 2 Human 5.6 pKi = 5.6 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 574 10 3 4 5.3 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccccn3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
10670662 468462 0 None 53 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 438 9 1 7 3.5 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2cccc(C)c2)c2cccc(C)c2)n1 10.1021/jm960274q
CHEMBL65833 468462 0 None 53 2 Human 7.6 pKi = 7.6 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 438 9 1 7 3.5 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2cccc(C)c2)c2cccc(C)c2)n1 10.1021/jm960274q
CHEMBL87296 489399 0 None None None Human 5.6 pKi = 5.6 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 571 7 5 6 0.4 CC(C)C[C@@H]1NC(=O)[C@@H](C(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](Cc2ccccc2)NC1=O 10.1016/0960-894X(95)00019-P
10645256 84467 0 None None None Rat 4.6 pKi = 4.6 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 410 6 1 4 5.2 CC(C)Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc3c2CCCC3)cc1 10.1021/jm970872k
CHEMBL148757 84467 0 None None None Rat 4.6 pKi = 4.6 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 410 6 1 4 5.2 CC(C)Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc3c2CCCC3)cc1 10.1021/jm970872k
10552683 468157 0 None 5 2 Human 6.6 pKi = 6.6 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 478 9 1 7 4.2 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccc(Cl)cc2)c2ccc(Cl)cc2)n1 10.1021/jm960274q
CHEMBL64009 468157 0 None 5 2 Human 6.6 pKi = 6.6 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 478 9 1 7 4.2 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccc(Cl)cc2)c2ccc(Cl)cc2)n1 10.1021/jm960274q
18660522 238383 0 None None None Human 7.6 pKi = 7.6 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 406 5 1 6 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccncn3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL346862 238383 0 None None None Human 7.6 pKi = 7.6 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 406 5 1 6 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccncn3)cc2)c1C 10.1016/s0960-894x(01)00791-0
46228116 462111 0 None 2 2 Mouse 7.6 pKi = 7.6 Binding
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 598 10 1 9 4.6 COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OCCBr)cc2)cc(OC)c1OC 10.1016/j.bmc.2009.08.058
CHEMBL603635 462111 0 None 2 2 Mouse 7.6 pKi = 7.6 Binding
Displacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomesDisplacement of [125I]ET1 from endothelin A receptor in DBA mouse microsomes
ChEMBL 598 10 1 9 4.6 COc1cc(CC2=C(c3ccc4c(c3)OCO4)C(=O)OC2(O)c2ccc(OCCBr)cc2)cc(OC)c1OC 10.1016/j.bmc.2009.08.058
3921421 216932 6 None 9 2 Human 7.6 pKi = 7.6 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 468 10 1 5 5.1 Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccccc2)(c2ccccc2)c2ccccc2)n1 10.1021/jm9910425
CHEMBL317233 216932 6 None 9 2 Human 7.6 pKi = 7.6 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 468 10 1 5 5.1 Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccccc2)(c2ccccc2)c2ccccc2)n1 10.1021/jm9910425
44314832 316824 0 None -251 2 Pig 6.6 pKi = 6.6 Binding
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1496 45 18 17 0.5 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
CHEMBL412065 316824 0 None -251 2 Pig 6.6 pKi = 6.6 Binding
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1496 45 18 17 0.5 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
44274960 199762 0 None 12 2 Human 6.6 pKi = 6.6 Binding
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 450 10 1 6 4.9 COc1cc(OC)nc(CC(C(=O)O)C(C)(Oc2ccc(C(C)C)cc2)c2ccccc2)n1 10.1021/jm030480f
CHEMBL283637 199762 0 None 12 2 Human 6.6 pKi = 6.6 Binding
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
ChEMBL 450 10 1 6 4.9 COc1cc(OC)nc(CC(C(=O)O)C(C)(Oc2ccc(C(C)C)cc2)c2ccccc2)n1 10.1021/jm030480f
44311699 469101 0 None -331 2 Human 6.6 pKi = 6.6 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 563 10 3 4 5.5 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccco3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
CHEMBL70686 469101 0 None -331 2 Human 6.6 pKi = 6.6 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 563 10 3 4 5.5 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccco3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
44307412 468653 0 None 12 2 Human 6.6 pKi = 6.6 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 466 10 0 8 4.5 COC(=O)C(Oc1nc(OC)cc(OC)n1)C(C)(Oc1ccc(C(C)C)cc1)c1ccccc1 10.1021/jm960274q
CHEMBL67325 468653 0 None 12 2 Human 6.6 pKi = 6.6 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 466 10 0 8 4.5 COC(=O)C(Oc1nc(OC)cc(OC)n1)C(C)(Oc1ccc(C(C)C)cc1)c1ccccc1 10.1021/jm960274q
10721484 216987 0 None -1 2 Human 6.6 pKi = 6.6 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 554 13 1 6 6.3 CCc1ccc(C(OCCc2ccc(OC)cc2)(c2ccc(CC)cc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 10.1021/jm9910425
CHEMBL317716 216987 0 None -1 2 Human 6.6 pKi = 6.6 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 554 13 1 6 6.3 CCc1ccc(C(OCCc2ccc(OC)cc2)(c2ccc(CC)cc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 10.1021/jm9910425
10621777 86490 0 None 12 2 Rat 5.6 pKi = 5.6 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 415 7 1 6 4.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1[N+](=O)[O-] 10.1021/jm970872k
CHEMBL150481 86490 0 None 12 2 Rat 5.6 pKi = 5.6 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 415 7 1 6 4.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1[N+](=O)[O-] 10.1021/jm970872k
9797546 84319 0 None None None Human 6.6 pKi = 6.6 Binding
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 329 4 1 5 3.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2cccnc2)c1C 10.1021/jm970872k
CHEMBL148637 84319 0 None None None Human 6.6 pKi = 6.6 Binding
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 329 4 1 5 3.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2cccnc2)c1C 10.1021/jm970872k
22103537 85492 0 None 144 2 Human 6.6 pKi = 6.6 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 395 5 1 6 4.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccno3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL149592 85492 0 None 144 2 Human 6.6 pKi = 6.6 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 395 5 1 6 4.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccno3)cc2)c1C 10.1016/s0960-894x(01)00791-0
44311810 203080 5 None -6 2 Human 4.6 pKi = 4.6 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
44312023 203080 5 None -6 2 Human 4.6 pKi = 4.6 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
9830098 203080 5 None -6 2 Human 4.6 pKi = 4.6 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
9938533 203080 5 None -6 2 Human 4.6 pKi = 4.6 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
CHEMBL307033 203080 5 None -6 2 Human 4.6 pKi = 4.6 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
CHEMBL310919 203080 5 None -6 2 Human 4.6 pKi = 4.6 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
CHEMBL311854 203080 5 None -6 2 Human 4.6 pKi = 4.6 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
CHEMBL72295 203080 5 None -6 2 Human 4.6 pKi = 4.6 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
10595347 85898 0 None 537 2 Rat 7.6 pKi = 7.6 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 370 6 1 4 4.7 CCCc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm970872k
CHEMBL149953 85898 0 None 537 2 Rat 7.6 pKi = 7.6 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 370 6 1 4 4.7 CCCc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm970872k
10741830 86259 0 None 3 2 Rat 5.6 pKi = 5.6 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 441 7 2 5 4.9 CC(=O)Nc1ccc(S(=O)(=O)Nc2onc(C)c2C)c(-c2ccc(CC(C)C)cc2)c1 10.1021/jm970872k
CHEMBL150269 86259 0 None 3 2 Rat 5.6 pKi = 5.6 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 441 7 2 5 4.9 CC(=O)Nc1ccc(S(=O)(=O)Nc2onc(C)c2C)c(-c2ccc(CC(C)C)cc2)c1 10.1021/jm970872k
15297287 329355 0 None -3 2 Human 4.6 pKi = 4.6 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 424 5 2 4 5.2 O=C(O)CN1C(=O)c2ccccc2Nc2ccc(OCc3cccc4ccccc34)cc21 10.1016/0960-894X(95)00019-P
CHEMBL421349 329355 0 None -3 2 Human 4.6 pKi = 4.6 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 424 5 2 4 5.2 O=C(O)CN1C(=O)c2ccccc2Nc2ccc(OCc3cccc4ccccc34)cc21 10.1016/0960-894X(95)00019-P
10599293 82475 0 None 128 2 Rat 7.5 pKi = 7.5 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 441 9 2 5 5.8 CCCNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
CHEMBL146845 82475 0 None 128 2 Rat 7.5 pKi = 7.5 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 441 9 2 5 5.8 CCCNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
10508342 19070 0 None -1 2 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 638 13 1 8 6.3 COc1ccc(CCOC(c2ccc(Cl)cc2)(c2ccc(Cl)cc2)C(Oc2nc3c(c(OC)n2)CCC3)C(=O)O)cc1OC 10.1021/jm9910425
CHEMBL103605 19070 0 None -1 2 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 638 13 1 8 6.3 COc1ccc(CCOC(c2ccc(Cl)cc2)(c2ccc(Cl)cc2)C(Oc2nc3c(c(OC)n2)CCC3)C(=O)O)cc1OC 10.1021/jm9910425
44311849 203122 0 None -5 2 Human 8.5 pKi = 8.5 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 694 14 2 7 5.8 CCCCS(=O)(=O)NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL307384 203122 0 None -5 2 Human 8.5 pKi = 8.5 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 694 14 2 7 5.8 CCCCS(=O)(=O)NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
11800649 18953 0 None 7 2 Human 8.5 pKi = 8.5 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 542 13 1 7 5.5 CCOc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
CHEMBL102797 18953 0 None 7 2 Human 8.5 pKi = 8.5 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 542 13 1 7 5.5 CCOc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
19085510 238299 0 None 6025 2 Human 8.5 pKi = 8.5 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 405 5 1 5 4.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cccnc3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL345951 238299 0 None 6025 2 Human 8.5 pKi = 8.5 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 405 5 1 5 4.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cccnc3)cc2)c1C 10.1016/s0960-894x(01)00791-0
10528863 18964 0 None 4 2 Human 8.5 pKi = 8.5 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 484 10 2 6 4.8 Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(O)cc2)(c2ccccc2)c2ccccc2)n1 10.1021/jm9910425
CHEMBL102868 18964 0 None 4 2 Human 8.5 pKi = 8.5 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 484 10 2 6 4.8 Cc1cc(C)nc(OC(C(=O)O)C(OCCc2ccc(O)cc2)(c2ccccc2)c2ccccc2)n1 10.1021/jm9910425
6433100 18895 17 None 2 2 Human 8.5 pKi = 8.5 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 528 12 1 7 5.1 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
9893800 18895 17 None 2 2 Human 8.5 pKi = 8.5 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 528 12 1 7 5.1 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
CHEMBL102405 18895 17 None 2 2 Human 8.5 pKi = 8.5 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 528 12 1 7 5.1 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
CHEMBL316735 18895 17 None 2 2 Human 8.5 pKi = 8.5 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 528 12 1 7 5.1 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1OC 10.1021/jm9910425
51003353 120858 0 None 10 2 Mouse 8.5 pKi = 8.5 Binding
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 886 26 1 17 5.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CCCCOc4cccnc4F)nn3)c2)cc1 10.1021/jm101110w
CHEMBL1672883 120858 0 None 10 2 Mouse 8.5 pKi = 8.5 Binding
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 886 26 1 17 5.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CCCCOc4cccnc4F)nn3)c2)cc1 10.1021/jm101110w
104865 1454 67 None -1 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assayDisplacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assay
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0014-2999(98)00891-7
3494 1454 67 None -1 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assayDisplacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assay
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0014-2999(98)00891-7
392 1454 67 None -1 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assayDisplacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assay
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0014-2999(98)00891-7
CHEMBL957 1454 67 None -1 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assayDisplacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assay
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0014-2999(98)00891-7
DB00559 1454 67 None -1 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assayDisplacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assay
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0014-2999(98)00891-7
10548722 19815 0 None 20892 2 Human 8.4 pKi = 8.4 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 395 5 1 6 4.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cnco3)cc2)c1C 10.1021/jm000105c
CHEMBL107574 19815 0 None 20892 2 Human 8.4 pKi = 8.4 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 395 5 1 6 4.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cnco3)cc2)c1C 10.1021/jm000105c
44311726 203134 0 None -10 2 Human 8.4 pKi = 8.4 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 667 12 3 7 4.8 C/C=C/S(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL307471 203134 0 None -10 2 Human 8.4 pKi = 8.4 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 667 12 3 7 4.8 C/C=C/S(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
51003354 120859 0 None 74 2 Mouse 8.4 pKi = 8.4 Binding
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 920 24 1 17 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CN(C)S(=O)(=O)c4ccc(F)cc4)nn3)c2)cc1 10.1021/jm101110w
CHEMBL1672884 120859 0 None 74 2 Mouse 8.4 pKi = 8.4 Binding
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 920 24 1 17 4.5 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CN(C)S(=O)(=O)c4ccc(F)cc4)nn3)c2)cc1 10.1021/jm101110w
18660523 85248 0 None None None Human 6.5 pKi = 6.5 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 406 5 1 6 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cncnc3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL149340 85248 0 None None None Human 6.5 pKi = 6.5 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 406 5 1 6 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cncnc3)cc2)c1C 10.1016/s0960-894x(01)00791-0
10525034 238401 0 None 89 2 Rat 7.5 pKi = 7.5 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 400 7 1 5 4.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(OCC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL347125 238401 0 None 89 2 Rat 7.5 pKi = 7.5 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 400 7 1 5 4.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(OCC(C)C)cc2)c1C 10.1021/jm970872k
10505357 218975 0 None 10 2 Human 7.5 pKi = 7.5 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 494 10 1 5 5.9 Cc1ccc(/C=C/COC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 10.1021/jm9910425
CHEMBL321984 218975 0 None 10 2 Human 7.5 pKi = 7.5 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 494 10 1 5 5.9 Cc1ccc(/C=C/COC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 10.1021/jm9910425
10624645 18681 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 482 10 1 5 5.4 Cc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 10.1021/jm9910425
CHEMBL100954 18681 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 482 10 1 5 5.4 Cc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 10.1021/jm9910425
10713411 329858 0 None None None Rat 7.5 pKi = 7.5 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 358 5 1 5 3.8 COc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm970872k
CHEMBL422496 329858 0 None None None Rat 7.5 pKi = 7.5 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 358 5 1 5 3.8 COc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm970872k
10671031 202754 0 None 29 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 446 9 1 7 3.2 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccc(F)cc2)c2ccc(F)cc2)n1 10.1021/jm960274q
CHEMBL304721 202754 0 None 29 2 Human 7.5 pKi = 7.5 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 446 9 1 7 3.2 COc1cc(OC)nc(OC(C(=O)O)C(OC)(c2ccc(F)cc2)c2ccc(F)cc2)n1 10.1021/jm960274q
9894460 473657 11 None 41 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assayDisplacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assay
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/s0014-2999(98)00891-7
CHEMBL8978 473657 11 None 41 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assayDisplacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assay
ChEMBL 539 10 2 7 4.8 CCCc1cc(C(=O)O)ccc1OC(C(=O)NS(=O)(=O)c1ccc(C(C)C)cc1)c1ccc2c(c1)OCO2 10.1016/s0014-2999(98)00891-7
10622410 97323 0 None None None Rat 6.5 pKi = 6.5 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 427 7 1 5 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2N(C)C)c1C 10.1021/jm970872k
CHEMBL151395 97323 0 None None None Rat 6.5 pKi = 6.5 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 427 7 1 5 5.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2N(C)C)c1C 10.1021/jm970872k
19934534 216356 0 None -5 2 Human 4.5 pKi = 4.5 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 468 6 3 4 5.0 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NC(=O)c3cc4ccccc4[nH]3)ccc21 10.1016/0960-894X(95)00019-P
CHEMBL314364 216356 0 None -5 2 Human 4.5 pKi = 4.5 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 468 6 3 4 5.0 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NC(=O)c3cc4ccccc4[nH]3)ccc21 10.1016/0960-894X(95)00019-P
10741834 97337 0 None 85 2 Rat 7.5 pKi = 7.5 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 441 8 2 5 5.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NC(C)C)c1C 10.1021/jm970872k
CHEMBL151422 97337 0 None 85 2 Rat 7.5 pKi = 7.5 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 441 8 2 5 5.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NC(C)C)c1C 10.1021/jm970872k
9864017 84752 0 None 194 2 Human 6.5 pKi = 6.5 Binding
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 367 4 2 4 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2cc3ccccc3[nH]2)c1C 10.1021/jm970872k
CHEMBL148967 84752 0 None 194 2 Human 6.5 pKi = 6.5 Binding
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 367 4 2 4 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2cc3ccccc3[nH]2)c1C 10.1021/jm970872k
10743346 202673 0 None 4 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 480 11 1 7 4.7 COc1cc(OC)nc(OC(C(=O)O)C(OCCC(C)(C)C)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
CHEMBL304173 202673 0 None 4 2 Human 6.5 pKi = 6.5 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 480 11 1 7 4.7 COc1cc(OC)nc(OC(C(=O)O)C(OCCC(C)(C)C)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
10709109 97420 0 None None None Rat 5.5 pKi = 5.5 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 297 4 1 6 2.0 Cc1noc(NS(=O)(=O)c2ccccc2[N+](=O)[O-])c1C 10.1021/jm970872k
CHEMBL151545 97420 0 None None None Rat 5.5 pKi = 5.5 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 297 4 1 6 2.0 Cc1noc(NS(=O)(=O)c2ccccc2[N+](=O)[O-])c1C 10.1021/jm970872k
10691438 97778 0 None 51 2 Rat 7.4 pKi = 7.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 384 7 1 4 5.1 CCCCc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm970872k
CHEMBL151926 97778 0 None 51 2 Rat 7.4 pKi = 7.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 384 7 1 4 5.1 CCCCc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm970872k
44213540 82929 0 None 831 2 Human 7.4 pKi = 7.4 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 421 5 1 5 4.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cccc[n+]3[O-])cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL147238 82929 0 None 831 2 Human 7.4 pKi = 7.4 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 421 5 1 5 4.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cccc[n+]3[O-])cc2)c1C 10.1016/s0960-894x(01)00791-0
10693130 240559 0 None 16 2 Rat 6.4 pKi = 6.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 414 7 1 5 5.0 COc1ccc(S(=O)(=O)Nc2onc(C)c2C)c(-c2ccc(CC(C)C)cc2)c1 10.1021/jm970872k
CHEMBL359152 240559 0 None 16 2 Rat 6.4 pKi = 6.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 414 7 1 5 5.0 COc1ccc(S(=O)(=O)Nc2onc(C)c2C)c(-c2ccc(CC(C)C)cc2)c1 10.1021/jm970872k
44365561 85688 0 None 524 2 Human 7.4 pKi = 7.4 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 404 5 1 4 5.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccccc3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL149763 85688 0 None 524 2 Human 7.4 pKi = 7.4 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 404 5 1 4 5.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ccccc3)cc2)c1C 10.1016/s0960-894x(01)00791-0
44365878 85704 0 None None None Human 5.4 pKi = 5.4 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 396 5 2 7 2.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nn[nH]n3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL149778 85704 0 None None None Human 5.4 pKi = 5.4 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 396 5 2 7 2.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nn[nH]n3)cc2)c1C 10.1016/s0960-894x(01)00791-0
10501299 238565 0 None 147 2 Rat 7.4 pKi = 7.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 402 6 1 5 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(SC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL348685 238565 0 None 147 2 Rat 7.4 pKi = 7.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 402 6 1 5 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(SC(C)C)cc2)c1C 10.1021/jm970872k
11813485 41954 0 None None None Human 7.4 pKi = 7.4 Binding
Compound was evaluated for its binding affinity towards human Endothelin A receptorCompound was evaluated for its binding affinity towards human Endothelin A receptor
ChEMBL 534 9 1 6 6.0 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm020138n
CHEMBL126755 41954 0 None None None Human 7.4 pKi = 7.4 Binding
Compound was evaluated for its binding affinity towards human Endothelin A receptorCompound was evaluated for its binding affinity towards human Endothelin A receptor
ChEMBL 534 9 1 6 6.0 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm020138n
10769887 217120 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 600 15 1 8 6.0 CCc1ccc(C(OCCc2ccc(OC)c(OC)c2)(c2ccc(CC)cc2)C(Oc2nc(C)cc(OC)n2)C(=O)O)cc1 10.1021/jm9910425
CHEMBL318535 217120 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 600 15 1 8 6.0 CCc1ccc(C(OCCc2ccc(OC)c(OC)c2)(c2ccc(CC)cc2)C(Oc2nc(C)cc(OC)n2)C(=O)O)cc1 10.1021/jm9910425
10526510 239684 0 None 12 2 Rat 5.4 pKi = 5.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 427 8 1 6 4.2 COc1cc(OC)nc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)n1 10.1021/jm970872k
CHEMBL356972 239684 0 None 12 2 Rat 5.4 pKi = 5.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 427 8 1 6 4.2 COc1cc(OC)nc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)n1 10.1021/jm970872k
22103385 239699 0 None 19054 2 Human 8.4 pKi = 8.4 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 396 5 1 7 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nnco3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL357077 239699 0 None 19054 2 Human 8.4 pKi = 8.4 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 396 5 1 7 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nnco3)cc2)c1C 10.1016/s0960-894x(01)00791-0
20747574 26378 0 None None None Human 8.4 pKi = 8.4 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 565 12 2 8 4.8 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COC)c1 10.1016/s0960-894x(03)00018-0
CHEMBL11840 26378 0 None None None Human 8.4 pKi = 8.4 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 565 12 2 8 4.8 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COC)c1 10.1016/s0960-894x(03)00018-0
22009947 176292 0 None 346 2 Human 8.4 pKi = 8.4 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 536 7 2 8 3.6 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 10.1007/s00044-004-0021-y
9807200 176292 0 None 346 2 Human 8.4 pKi = 8.4 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 536 7 2 8 3.6 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261358 176292 0 None 346 2 Human 8.4 pKi = 8.4 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 536 7 2 8 3.6 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 10.1007/s00044-004-0021-y
CHEMBL2261359 176292 0 None 346 2 Human 8.4 pKi = 8.4 Binding
Displacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cellsDisplacement of [I125]ET1 from Homo sapiens (human) ETA receptor expressed in CHO cells
ChEMBL 536 7 2 8 3.6 COc1cc(C)ccc1S(=O)(=O)NC(=O)C(c1ccc2c(c1)OCO2)c1cn(C)c2cc(C(=O)O)ccc12 10.1007/s00044-004-0021-y
51003352 120857 0 None 1230 2 Mouse 8.4 pKi = 8.4 Binding
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 1020 35 1 21 4.7 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCOCc3cn(CCOCCOCCOCCOc4cccnc4F)nn3)c2)cc1 10.1021/jm101110w
CHEMBL1672882 120857 0 None 1230 2 Mouse 8.4 pKi = 8.4 Binding
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 1020 35 1 21 4.7 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCOCc3cn(CCOCCOCCOCCOc4cccnc4F)nn3)c2)cc1 10.1021/jm101110w
9908909 19645 12 None -1 3 Rat 8.3 pKi = 8.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 399 6 2 5 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2N)c1C 10.1021/jm970872k
CHEMBL106684 19645 12 None -1 3 Rat 8.3 pKi = 8.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 399 6 2 5 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2N)c1C 10.1021/jm970872k
10811477 19157 0 None 19952 2 Human 8.3 pKi = 8.3 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 409 5 1 6 4.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncoc3C)cc2)c1C 10.1021/jm000105c
CHEMBL104172 19157 0 None 19952 2 Human 8.3 pKi = 8.3 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 409 5 1 6 4.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncoc3C)cc2)c1C 10.1021/jm000105c
9908909 19645 12 None 1 3 Human 8.3 pKi = 8.3 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 399 6 2 5 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2N)c1C 10.1021/jm000105c
CHEMBL106684 19645 12 None 1 3 Human 8.3 pKi = 8.3 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 399 6 2 5 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2N)c1C 10.1021/jm000105c
101039204 1466 45 None -2 3 Rat 7.4 pKi = 7.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm970872k
443289 1466 45 None -2 3 Rat 7.4 pKi = 7.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm970872k
997 1466 45 None -2 3 Rat 7.4 pKi = 7.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm970872k
CHEMBL314691 1466 45 None -2 3 Rat 7.4 pKi = 7.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm970872k
CHEMBL4095638 1466 45 None -2 3 Rat 7.4 pKi = 7.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm970872k
DB12054 1466 45 None -2 3 Rat 7.4 pKi = 7.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 610 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)CC(=O)O)C(C)C)C 10.1021/jm970872k
9950670 86971 0 None None None Rat 7.4 pKi = 7.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 358 5 2 5 3.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2CO)c1C 10.1021/jm970872k
CHEMBL150891 86971 0 None None None Rat 7.4 pKi = 7.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 358 5 2 5 3.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2CO)c1C 10.1021/jm970872k
18004820 40341 0 None None None Human 7.4 pKi = 7.4 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 527 9 2 7 4.7 CCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
CHEMBL12333 40341 0 None None None Human 7.4 pKi = 7.4 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 527 9 2 7 4.7 CCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
10208527 198483 0 None None None Human 7.4 pKi = 7.4 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 526 9 1 7 5.8 CCCc1nc(Cl)c(C(C)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
CHEMBL274154 198483 0 None None None Human 7.4 pKi = 7.4 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 526 9 1 7 5.8 CCCc1nc(Cl)c(C(C)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
11795351 86265 0 None 109 2 Rat 6.4 pKi = 6.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 401 6 1 4 4.8 CC(C)Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc(Cl)nn2)cc1 10.1021/jm970872k
CHEMBL150273 86265 0 None 109 2 Rat 6.4 pKi = 6.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 401 6 1 4 4.8 CC(C)Cc1ccc(-c2ccccc2S(=O)(=O)Nc2ccc(Cl)nn2)cc1 10.1021/jm970872k
44303148 468199 0 None None None Human 6.4 pKi = 6.4 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 456 4 1 5 5.1 O=C1O[C@@](O)(c2ccc(Cl)c(Cl)c2)C(Cc2ccccc2)C1c1ccc2c(c1)OCO2 10.1021/jm990504b
CHEMBL64200 468199 0 None None None Human 6.4 pKi = 6.4 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 456 4 1 5 5.1 O=C1O[C@@](O)(c2ccc(Cl)c(Cl)c2)C(Cc2ccccc2)C1c1ccc2c(c1)OCO2 10.1021/jm990504b
19934549 215677 0 None -3 2 Human 4.4 pKi = 4.4 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 439 6 2 3 5.4 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(Cc3c[nH]c4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
CHEMBL313184 215677 0 None -3 2 Human 4.4 pKi = 4.4 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 439 6 2 3 5.4 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(Cc3c[nH]c4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
10280531 327952 0 None None None Human 6.4 pKi = 6.4 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 541 10 2 7 5.1 CCCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
CHEMBL417429 327952 0 None None None Human 6.4 pKi = 6.4 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 541 10 2 7 5.1 CCCCc1nc(Cl)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
10528341 38483 0 None 95 2 Rat 7.4 pKi = 7.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 458 9 2 6 4.4 Cc1noc(NS(=O)(=O)c2cccc(OCC(=O)O)c2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL1204523 38483 0 None 95 2 Rat 7.4 pKi = 7.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 458 9 2 6 4.4 Cc1noc(NS(=O)(=O)c2cccc(OCC(=O)O)c2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
155543936 347336 0 None -218776 2 Rat 5.4 pKi = 5.4 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumCompound was evaluated for the binding affinity to Endothelin A receptor in the rat atrium
ChEMBL 2514 48 34 38 -9.8 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CC(N)=O)NC2=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00087a001
CHEMBL4524100 347336 0 None -218776 2 Rat 5.4 pKi = 5.4 Binding
Compound was evaluated for the binding affinity to Endothelin A receptor in the rat atriumCompound was evaluated for the binding affinity to Endothelin A receptor in the rat atrium
ChEMBL 2514 48 34 38 -9.8 CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@H]([C@@H](C)O)C(=O)N[C@H]2CSSC[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CC(N)=O)NC2=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1)C(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00087a001
10407051 200555 0 None 5 2 Human 6.4 pKi = 6.4 Binding
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 374 5 1 3 4.7 COc1ccc([C@H]2c3ccccc3[C@@H](c3ccc(OC)cc3)[C@@H]2C(=O)O)cc1 10.1021/jm00037a003
CHEMBL290026 200555 0 None 5 2 Human 6.4 pKi = 6.4 Binding
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 374 5 1 3 4.7 COc1ccc([C@H]2c3ccccc3[C@@H](c3ccc(OC)cc3)[C@@H]2C(=O)O)cc1 10.1021/jm00037a003
10647471 85743 0 None 125 2 Rat 7.4 pKi = 7.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 456 7 3 5 4.7 CNC(=O)Nc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
CHEMBL149818 85743 0 None 125 2 Rat 7.4 pKi = 7.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 456 7 3 5 4.7 CNC(=O)Nc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
10045790 278859 0 None 17 2 Human 7.4 pKi = 7.4 Binding
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 388 4 1 4 4.4 COc1ccc([C@H]2c3ccccc3[C@@H](c3ccc4c(c3)OCO4)[C@@H]2C(=O)O)cc1 10.1021/jm00037a003
CHEMBL38537 278859 0 None 17 2 Human 7.4 pKi = 7.4 Binding
Inhibition of [125I]ET1 binding to cloned human ET-A receptorInhibition of [125I]ET1 binding to cloned human ET-A receptor
ChEMBL 388 4 1 4 4.4 COc1ccc([C@H]2c3ccccc3[C@@H](c3ccc4c(c3)OCO4)[C@@H]2C(=O)O)cc1 10.1021/jm00037a003
22103589 84600 0 None None None Human 7.4 pKi = 7.4 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 394 5 2 5 4.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncc[nH]3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL148855 84600 0 None None None Human 7.4 pKi = 7.4 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 394 5 2 5 4.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncc[nH]3)cc2)c1C 10.1016/s0960-894x(01)00791-0
3887 4239 39 None -436 4 Pig 6.4 pKi = 6.4 Binding
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 573 10 3 3 5.9 Cc1cc(C)cc(c1)C(=O)N([C@@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)Cc1ccc(cc1)c1ccccc1)C 10.1016/0960-894X(96)00421-0
5311192 4239 39 None -436 4 Pig 6.4 pKi = 6.4 Binding
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 573 10 3 3 5.9 Cc1cc(C)cc(c1)C(=O)N([C@@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)Cc1ccc(cc1)c1ccccc1)C 10.1016/0960-894X(96)00421-0
CHEMBL72410 4239 39 None -436 4 Pig 6.4 pKi = 6.4 Binding
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 573 10 3 3 5.9 Cc1cc(C)cc(c1)C(=O)N([C@@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)Cc1ccc(cc1)c1ccccc1)C 10.1016/0960-894X(96)00421-0
3887 4239 39 None -436 4 Human 6.4 pKi = 6.4 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 573 10 3 3 5.9 Cc1cc(C)cc(c1)C(=O)N([C@@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)Cc1ccc(cc1)c1ccccc1)C 10.1016/s0960-894x(98)00387-4
5311192 4239 39 None -436 4 Human 6.4 pKi = 6.4 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 573 10 3 3 5.9 Cc1cc(C)cc(c1)C(=O)N([C@@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)Cc1ccc(cc1)c1ccccc1)C 10.1016/s0960-894x(98)00387-4
CHEMBL72410 4239 39 None -436 4 Human 6.4 pKi = 6.4 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 573 10 3 3 5.9 Cc1cc(C)cc(c1)C(=O)N([C@@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)Cc1ccc(cc1)c1ccccc1)C 10.1016/s0960-894x(98)00387-4
10499516 239603 0 None None None Rat 5.4 pKi = 5.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 372 5 2 5 3.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(C(=O)O)cc2)c1C 10.1021/jm970872k
CHEMBL356220 239603 0 None None None Rat 5.4 pKi = 5.4 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 372 5 2 5 3.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(C(=O)O)cc2)c1C 10.1021/jm970872k
44311701 332880 1 None -213 2 Human 7.4 pKi = 7.4 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 564 10 3 5 4.9 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
CHEMBL433106 332880 1 None -213 2 Human 7.4 pKi = 7.4 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 564 10 3 5 4.9 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
10280562 39408 0 None None None Human 6.3 pKi = 6.3 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 542 9 1 8 5.4 CCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
CHEMBL12172 39408 0 None None None Human 6.3 pKi = 6.3 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 542 9 1 8 5.4 CCCc1nc(Cl)c(C(=O)OC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
10516176 470060 2 None None None Rat 5.3 pKi = 5.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 270 3 1 4 2.2 Cc1noc(NS(=O)(=O)c2ccccc2F)c1C 10.1021/jm970872k
CHEMBL78499 470060 2 None None None Rat 5.3 pKi = 5.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 270 3 1 4 2.2 Cc1noc(NS(=O)(=O)c2ccccc2F)c1C 10.1021/jm970872k
10793160 198679 0 None -2 2 Human 7.3 pKi = 7.3 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 570 13 1 8 5.6 COc1cc(/C=C/COC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc(OC)c1OC 10.1021/jm9910425
CHEMBL275471 198679 0 None -2 2 Human 7.3 pKi = 7.3 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 570 13 1 8 5.6 COc1cc(/C=C/COC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc(OC)c1OC 10.1021/jm9910425
122272 197418 36 None 1 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm9505369
CHEMBL267458 197418 36 None 1 2 Human 7.3 pKi = 7.3 Binding
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm9505369
122272 197418 36 None 1 2 Human 7.3 pKi = 7.3 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm980217s
CHEMBL267458 197418 36 None 1 2 Human 7.3 pKi = 7.3 Binding
Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm980217s
10810897 240098 0 None 3801 2 Rat 8.3 pKi = 8.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 398 6 1 4 5.3 Cc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
CHEMBL358254 240098 0 None 3801 2 Rat 8.3 pKi = 8.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 398 6 1 4 5.3 Cc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
10621010 329781 0 None 186 2 Rat 8.3 pKi = 8.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 400 6 2 5 4.7 Cc1noc(NS(=O)(=O)c2cccc(O)c2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL421955 329781 0 None 186 2 Rat 8.3 pKi = 8.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 400 6 2 5 4.7 Cc1noc(NS(=O)(=O)c2cccc(O)c2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
9871837 39101 0 None None None Human 8.3 pKi = 8.3 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 535 10 2 7 4.9 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1016/s0960-894x(03)00018-0
CHEMBL12106 39101 0 None None None Human 8.3 pKi = 8.3 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 535 10 2 7 4.9 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1016/s0960-894x(03)00018-0
9985001 197332 0 None None None Human 8.3 pKi = 8.3 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 549 10 2 7 5.2 CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1016/s0960-894x(03)00018-0
CHEMBL266628 197332 0 None None None Human 8.3 pKi = 8.3 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 549 10 2 7 5.2 CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(C)c1 10.1016/s0960-894x(03)00018-0
44311772 203083 0 None -10 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 628 15 2 8 4.1 CCCCS(=O)(=O)NC(=O)C(CCSC)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL307045 203083 0 None -10 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 628 15 2 8 4.1 CCCCS(=O)(=O)NC(=O)C(CCSC)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
44311838 469515 0 None -13 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 655 12 3 7 4.3 CCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL73373 469515 0 None -13 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 655 12 3 7 4.3 CCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
44311850 203239 0 None -10 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 717 13 3 7 5.5 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NS(=O)(=O)Cc2ccccc2)c1 10.1016/s0960-894x(98)00387-4
CHEMBL308269 203239 0 None -10 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 717 13 3 7 5.5 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccno3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NS(=O)(=O)Cc2ccccc2)c1 10.1016/s0960-894x(98)00387-4
44311773 469568 0 None -7 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 582 13 2 7 3.8 CCCCS(=O)(=O)NC(=O)C(CC)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL73835 469568 0 None -7 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 582 13 2 7 3.8 CCCCS(=O)(=O)NC(=O)C(CC)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
22103743 86252 0 None 9332 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 411 5 1 6 4.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nccs3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL150260 86252 0 None 9332 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 411 5 1 6 4.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3nccs3)cc2)c1C 10.1016/s0960-894x(01)00791-0
10667808 238056 0 None 338 2 Rat 7.3 pKi = 7.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 385 6 2 5 4.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(NC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL343867 238056 0 None 338 2 Rat 7.3 pKi = 7.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 385 6 2 5 4.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(NC(C)C)cc2)c1C 10.1021/jm970872k
10761688 238566 0 None 380 2 Rat 7.3 pKi = 7.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 370 5 1 4 4.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(C(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL348700 238566 0 None 380 2 Rat 7.3 pKi = 7.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 370 5 1 4 4.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(C(C)C)cc2)c1C 10.1021/jm970872k
10501166 85299 0 None 47 2 Rat 6.3 pKi = 6.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 400 6 2 5 4.7 Cc1noc(NS(=O)(=O)c2cc(O)ccc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL149391 85299 0 None 47 2 Rat 6.3 pKi = 6.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 400 6 2 5 4.7 Cc1noc(NS(=O)(=O)c2cc(O)ccc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
44314444 317255 0 None -457 2 Pig 5.3 pKi = 5.3 Binding
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1470 45 18 17 -0.5 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
CHEMBL413604 317255 0 None -457 2 Pig 5.3 pKi = 5.3 Binding
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1470 45 18 17 -0.5 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
9799352 239720 0 None None None Human 6.3 pKi = 6.3 Binding
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 367 4 2 4 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2c[nH]c3ccccc23)c1C 10.1021/jm970872k
CHEMBL357331 239720 0 None None None Human 6.3 pKi = 6.3 Binding
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 367 4 2 4 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2c[nH]c3ccccc23)c1C 10.1021/jm970872k
10690608 239676 0 None 112 2 Rat 7.3 pKi = 7.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 371 5 1 5 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(N(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL356901 239676 0 None 112 2 Rat 7.3 pKi = 7.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 371 5 1 5 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(N(C)C)cc2)c1C 10.1021/jm970872k
44311700 202878 0 None -234 2 Human 7.3 pKi = 7.3 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 579 10 3 4 6.0 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccsc3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
CHEMBL305462 202878 0 None -234 2 Human 7.3 pKi = 7.3 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 579 10 3 4 6.0 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3ccsc3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
122272 197418 36 None -1 2 Rat 7.3 pKi = 7.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm970872k
CHEMBL267458 197418 36 None -1 2 Rat 7.3 pKi = 7.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm970872k
10521258 239902 0 None 416 2 Rat 7.3 pKi = 7.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 342 4 1 4 4.1 Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm970872k
CHEMBL358020 239902 0 None 416 2 Rat 7.3 pKi = 7.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 342 4 1 4 4.1 Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1021/jm970872k
122272 197418 36 None 1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards ET1 receptor was determined in A10 cellsBinding affinity towards ET1 receptor was determined in A10 cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00029a001
CHEMBL267458 197418 36 None 1 2 Human 7.3 pKi = 7.3 Binding
Binding affinity towards ET1 receptor was determined in A10 cellsBinding affinity towards ET1 receptor was determined in A10 cells
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm00029a001
10166104 39075 0 None None None Human 7.3 pKi = 7.3 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 549 10 1 7 5.2 CCCc1nc(CC)c(C(=O)N(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
CHEMBL12102 39075 0 None None None Human 7.3 pKi = 7.3 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 549 10 1 7 5.2 CCCc1nc(CC)c(C(=O)N(C)C)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
17979745 41787 0 None None None Human 7.3 pKi = 7.3 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 521 10 2 7 4.6 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
CHEMBL12592 41787 0 None None None Human 7.3 pKi = 7.3 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 521 10 2 7 4.6 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)cc1 10.1016/s0960-894x(03)00018-0
122272 197418 36 None 1 2 Human 7.3 pKi = 7.3 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm000105c
CHEMBL267458 197418 36 None 1 2 Human 7.3 pKi = 7.3 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 345 4 1 5 3.3 Cc1noc(NS(=O)(=O)c2cccc3c(N(C)C)cccc23)c1C 10.1021/jm000105c
10718666 240124 0 None 3 2 Rat 6.3 pKi = 6.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 457 9 3 6 4.5 Cc1noc(NS(=O)(=O)c2ccc(NCC(=O)O)cc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL358461 240124 0 None 3 2 Rat 6.3 pKi = 6.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 457 9 3 6 4.5 Cc1noc(NS(=O)(=O)c2ccc(NCC(=O)O)cc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
10670536 239701 0 None None None Rat 6.3 pKi = 6.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 435 6 1 6 3.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(S(=O)(=O)N(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL357099 239701 0 None None None Rat 6.3 pKi = 6.3 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 435 6 1 6 3.0 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(S(=O)(=O)N(C)C)cc2)c1C 10.1021/jm970872k
1009 399 28 None -645 2 Human 5.3 pKi = 5.3 Binding
125I-labelled ET-1 saturation binding studies with EDNRA125I-labelled ET-1 saturation binding studies with EDNRA
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.6019/CHEMBL4507261
5310991 399 28 None -645 2 Human 5.3 pKi = 5.3 Binding
125I-labelled ET-1 saturation binding studies with EDNRA125I-labelled ET-1 saturation binding studies with EDNRA
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.6019/CHEMBL4507261
CHEMBL332794 399 28 None -645 2 Human 5.3 pKi = 5.3 Binding
125I-labelled ET-1 saturation binding studies with EDNRA125I-labelled ET-1 saturation binding studies with EDNRA
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.6019/CHEMBL4507261
1009 399 28 None -645 2 Human 5.3 pKi = 5.3 Binding
Binding affinity to human ETA receptor transfected in CHO cell membrane assessed as inhibition constant incubated for 3 hrs by 125I-labelled ET-1 saturation binding assayBinding affinity to human ETA receptor transfected in CHO cell membrane assessed as inhibition constant incubated for 3 hrs by 125I-labelled ET-1 saturation binding assay
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.1042/cs103s107s
5310991 399 28 None -645 2 Human 5.3 pKi = 5.3 Binding
Binding affinity to human ETA receptor transfected in CHO cell membrane assessed as inhibition constant incubated for 3 hrs by 125I-labelled ET-1 saturation binding assayBinding affinity to human ETA receptor transfected in CHO cell membrane assessed as inhibition constant incubated for 3 hrs by 125I-labelled ET-1 saturation binding assay
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.1042/cs103s107s
CHEMBL332794 399 28 None -645 2 Human 5.3 pKi = 5.3 Binding
Binding affinity to human ETA receptor transfected in CHO cell membrane assessed as inhibition constant incubated for 3 hrs by 125I-labelled ET-1 saturation binding assayBinding affinity to human ETA receptor transfected in CHO cell membrane assessed as inhibition constant incubated for 3 hrs by 125I-labelled ET-1 saturation binding assay
ChEMBL 558 11 2 6 5.8 CCCOc1ccc(cc1)[C@@H]1N(CC(=O)Nc2c(CC)cccc2CC)C[C@@H]([C@H]1C(=O)O)c1ccc2c(c1)OCO2 10.1042/cs103s107s
10088869 291108 0 None None None Human 5.3 pKi = 5.3 Binding
Inhibition of [125I]ET1 binding to cloned human Endothelin A receptorInhibition of [125I]ET1 binding to cloned human Endothelin A receptor
ChEMBL 344 4 1 2 4.7 COc1ccc([C@H]2c3ccccc3[C@@H](c3ccccc3)[C@@H]2C(=O)O)cc1 10.1021/jm00037a003
CHEMBL39057 291108 0 None None None Human 5.3 pKi = 5.3 Binding
Inhibition of [125I]ET1 binding to cloned human Endothelin A receptorInhibition of [125I]ET1 binding to cloned human Endothelin A receptor
ChEMBL 344 4 1 2 4.7 COc1ccc([C@H]2c3ccccc3[C@@H](c3ccccc3)[C@@H]2C(=O)O)cc1 10.1021/jm00037a003
10839202 238010 0 None 6 2 Rat 5.2 pKi = 5.2 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 503 8 2 5 6.2 Cc1noc(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3)cc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL343477 238010 0 None 6 2 Rat 5.2 pKi = 5.2 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 503 8 2 5 6.2 Cc1noc(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3)cc2-c2ccc(CC(C)C)cc2)c1C 10.1021/jm970872k
10563752 84395 1 None None None Rat 5.2 pKi = 5.2 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccccc2N)c1C 10.1021/jm970872k
CHEMBL148702 84395 1 None None None Rat 5.2 pKi = 5.2 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccccc2N)c1C 10.1021/jm970872k
177236 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity against human Endothelin A receptor; orally active in vivo at 30 mg/kg, poBinding affinity against human Endothelin A receptor; orally active in vivo at 30 mg/kg, po
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm030480f
3508 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity against human Endothelin A receptor; orally active in vivo at 30 mg/kg, poBinding affinity against human Endothelin A receptor; orally active in vivo at 30 mg/kg, po
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm030480f
9931375 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity against human Endothelin A receptor; orally active in vivo at 30 mg/kg, poBinding affinity against human Endothelin A receptor; orally active in vivo at 30 mg/kg, po
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm030480f
9953358 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity against human Endothelin A receptor; orally active in vivo at 30 mg/kg, poBinding affinity against human Endothelin A receptor; orally active in vivo at 30 mg/kg, po
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm030480f
CHEMBL23261 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity against human Endothelin A receptor; orally active in vivo at 30 mg/kg, poBinding affinity against human Endothelin A receptor; orally active in vivo at 30 mg/kg, po
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm030480f
CHEMBL25344 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity against human Endothelin A receptor; orally active in vivo at 30 mg/kg, poBinding affinity against human Endothelin A receptor; orally active in vivo at 30 mg/kg, po
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm030480f
CHEMBL5687038 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity against human Endothelin A receptor; orally active in vivo at 30 mg/kg, poBinding affinity against human Endothelin A receptor; orally active in vivo at 30 mg/kg, po
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm030480f
DB04883 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity against human Endothelin A receptor; orally active in vivo at 30 mg/kg, poBinding affinity against human Endothelin A receptor; orally active in vivo at 30 mg/kg, po
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm030480f
177236 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/s0014-2999(98)00891-7
3508 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/s0014-2999(98)00891-7
9931375 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/s0014-2999(98)00891-7
9953358 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/s0014-2999(98)00891-7
CHEMBL23261 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/s0014-2999(98)00891-7
CHEMBL25344 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/s0014-2999(98)00891-7
CHEMBL5687038 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/s0014-2999(98)00891-7
DB04883 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/s0014-2999(98)00891-7
44311803 469453 0 None -26 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 699 15 3 8 4.3 CCOCCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL72924 469453 0 None -26 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 699 15 3 8 4.3 CCOCCS(=O)(=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
177236 2734 40 None -2 3 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm030528p
3508 2734 40 None -2 3 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm030528p
9931375 2734 40 None -2 3 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm030528p
9953358 2734 40 None -2 3 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm030528p
CHEMBL23261 2734 40 None -2 3 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm030528p
CHEMBL25344 2734 40 None -2 3 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm030528p
CHEMBL5687038 2734 40 None -2 3 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm030528p
DB04883 2734 40 None -2 3 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm030528p
177236 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm960274q
3508 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm960274q
9931375 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm960274q
9953358 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm960274q
CHEMBL23261 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm960274q
CHEMBL25344 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm960274q
CHEMBL5687038 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm960274q
DB04883 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1021/jm960274q
177236 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
3508 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
9931375 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
9953358 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
CHEMBL23261 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
CHEMBL25344 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
CHEMBL5687038 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
DB04883 2734 40 None 2 3 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation countingDisplacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting
ChEMBL 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2016.06.014
11006149 201233 0 None 380 2 Human 8.2 pKi = 8.2 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 550 8 1 7 6.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C(=O)C(C)(C)C)C(C)C)c1C 10.1021/jm020289q
CHEMBL29502 201233 0 None 380 2 Human 8.2 pKi = 8.2 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 550 8 1 7 6.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C(=O)C(C)(C)C)C(C)C)c1C 10.1021/jm020289q
10648996 18702 0 None 3 2 Human 8.2 pKi = 8.2 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 498 11 1 6 5.1 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 10.1021/jm9910425
CHEMBL101069 18702 0 None 3 2 Human 8.2 pKi = 8.2 Binding
Inhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cellsInhibition of [125I]-ET-1 (ETA assay) binding to human cloned Endothelin A receptor in CHO cells
ChEMBL 498 11 1 6 5.1 COc1ccc(CCOC(c2ccccc2)(c2ccccc2)C(Oc2nc(C)cc(C)n2)C(=O)O)cc1 10.1021/jm9910425
18660520 83010 0 None 3548 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 406 5 1 6 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cnccn3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL147340 83010 0 None 3548 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 406 5 1 6 4.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3cnccn3)cc2)c1C 10.1016/s0960-894x(01)00791-0
10741151 86483 0 None 223 2 Rat 8.2 pKi = 8.2 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 427 8 2 5 5.4 CCNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
CHEMBL150474 86483 0 None 223 2 Rat 8.2 pKi = 8.2 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 427 8 2 5 5.4 CCNc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
10503421 238258 0 None 245 2 Rat 8.2 pKi = 8.2 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 443 9 3 6 4.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NCCO)c1C 10.1021/jm970872k
CHEMBL345542 238258 0 None 245 2 Rat 8.2 pKi = 8.2 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 443 9 3 6 4.4 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NCCO)c1C 10.1021/jm970872k
104865 1454 67 None -1 3 Human 8.2 pKi = 8.2 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm970101g
3494 1454 67 None -1 3 Human 8.2 pKi = 8.2 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm970101g
392 1454 67 None -1 3 Human 8.2 pKi = 8.2 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm970101g
CHEMBL957 1454 67 None -1 3 Human 8.2 pKi = 8.2 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm970101g
DB00559 1454 67 None -1 3 Human 8.2 pKi = 8.2 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm970101g
104865 1454 67 None -1 3 Human 8.2 pKi = 8.2 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0014-2999(98)00891-7
3494 1454 67 None -1 3 Human 8.2 pKi = 8.2 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0014-2999(98)00891-7
392 1454 67 None -1 3 Human 8.2 pKi = 8.2 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0014-2999(98)00891-7
CHEMBL957 1454 67 None -1 3 Human 8.2 pKi = 8.2 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0014-2999(98)00891-7
DB00559 1454 67 None -1 3 Human 8.2 pKi = 8.2 Binding
Binding affinity to ETA receptor (unknown origin) assessed as inhibition constantBinding affinity to ETA receptor (unknown origin) assessed as inhibition constant
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1016/s0014-2999(98)00891-7
104865 1454 67 None 1 3 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm030528p
3494 1454 67 None 1 3 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm030528p
392 1454 67 None 1 3 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm030528p
CHEMBL957 1454 67 None 1 3 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm030528p
DB00559 1454 67 None 1 3 Rat 8.2 pKi = 8.2 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm030528p
44265871 331728 0 None 53 2 Human 8.2 pKi = 8.2 Binding
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 547 10 2 8 4.6 COc1ccccc1Cc1c(CCCO)nc(-c2ncccn2)nc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1 10.1021/jm9505369
CHEMBL428661 331728 0 None 53 2 Human 8.2 pKi = 8.2 Binding
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 547 10 2 8 4.6 COc1ccccc1Cc1c(CCCO)nc(-c2ncccn2)nc1NS(=O)(=O)c1ccc(C(C)(C)C)cc1 10.1021/jm9505369
22103787 84419 0 None 1380 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 394 5 1 6 3.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-n3cccn3)cc2)c1C 10.1016/s0960-894x(01)00791-0
CHEMBL148719 84419 0 None 1380 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to CHO cells stably expressing human Endothelin A receptor.Binding affinity to CHO cells stably expressing human Endothelin A receptor.
ChEMBL 394 5 1 6 3.9 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-n3cccn3)cc2)c1C 10.1016/s0960-894x(01)00791-0
44311989 469469 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 610 14 2 7 4.4 CCCCS(=O)(=O)NC(=O)C(NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)CC 10.1016/s0960-894x(98)00387-4
CHEMBL73042 469469 0 None -1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 610 14 2 7 4.4 CCCCS(=O)(=O)NC(=O)C(NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)CC 10.1016/s0960-894x(98)00387-4
10620958 85132 0 None 331 2 Rat 7.2 pKi = 7.2 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 399 6 1 5 4.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(N(C)C(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL149241 85132 0 None 331 2 Rat 7.2 pKi = 7.2 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 399 6 1 5 4.6 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(N(C)C(C)C)cc2)c1C 10.1021/jm970872k
10803738 237768 0 None None None Rat 6.2 pKi = 6.2 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 294 4 1 4 3.2 Cc1noc(NS(=O)(=O)c2ccccc2C(C)C)c1C 10.1021/jm970872k
CHEMBL342498 237768 0 None None None Rat 6.2 pKi = 6.2 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 294 4 1 4 3.2 Cc1noc(NS(=O)(=O)c2ccccc2C(C)C)c1C 10.1021/jm970872k
3219 369899 38 None None None Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 372 4 1 3 4.0 CC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc(S(C)(=O)=O)cc1 nan
5472495 369899 38 None None None Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 372 4 1 3 4.0 CC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc(S(C)(=O)=O)cc1 nan
CHEMBL488025 369899 38 None None None Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 372 4 1 3 4.0 CC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc(S(C)(=O)=O)cc1 nan
DB06246 369899 38 None None None Human 5.2 pKi = 5.2 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
ChEMBL 372 4 1 3 4.0 CC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc(S(C)(=O)=O)cc1 nan
10691439 97829 0 None 245 2 Rat 7.2 pKi = 7.2 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 384 4 1 4 5.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(C(C)(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL151971 97829 0 None 245 2 Rat 7.2 pKi = 7.2 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 384 4 1 4 5.1 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(C(C)(C)C)cc2)c1C 10.1021/jm970872k
10783588 330554 0 None None None Rat 7.2 pKi = 7.2 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 343 4 2 5 3.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2cccc(N)c2)c1C 10.1021/jm970872k
CHEMBL424504 330554 0 None None None Rat 7.2 pKi = 7.2 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 343 4 2 5 3.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2cccc(N)c2)c1C 10.1021/jm970872k
44314783 331270 0 None -7943 2 Pig 6.2 pKi = 6.2 Binding
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1576 47 19 18 0.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
77282213 331270 0 None -7943 2 Pig 6.2 pKi = 6.2 Binding
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1576 47 19 18 0.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
CHEMBL427778 331270 0 None -7943 2 Pig 6.2 pKi = 6.2 Binding
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1576 47 19 18 0.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
5310990 327639 15 None 30 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
CHEMBL428504 327639 15 None 30 2 Human 7.2 pKi = 7.2 Binding
Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cellsInhibitory activity against human Endothelin A receptor in chinese hamster ovary cells
ChEMBL 510 12 1 6 4.7 CCCCN(CCCC)C(=O)CN1C[C@@H](c2ccc3c(c2)OCO3)[C@H](C(=O)O)[C@H]1c1ccc(OC)cc1 10.1021/jm9505369
10600059 97805 0 None None None Rat 5.2 pKi = 5.2 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 460 8 1 4 6.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1Cc1ccccc1 10.1021/jm970872k
CHEMBL151954 97805 0 None None None Rat 5.2 pKi = 5.2 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 460 8 1 4 6.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2)c1Cc1ccccc1 10.1021/jm970872k
44311810 203080 5 None -6 2 Human 5.2 pKi = 5.2 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
44312023 203080 5 None -6 2 Human 5.2 pKi = 5.2 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
9830098 203080 5 None -6 2 Human 5.2 pKi = 5.2 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
9938533 203080 5 None -6 2 Human 5.2 pKi = 5.2 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
CHEMBL307033 203080 5 None -6 2 Human 5.2 pKi = 5.2 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
CHEMBL310919 203080 5 None -6 2 Human 5.2 pKi = 5.2 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
CHEMBL311854 203080 5 None -6 2 Human 5.2 pKi = 5.2 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
CHEMBL72295 203080 5 None -6 2 Human 5.2 pKi = 5.2 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
22574723 39828 0 None None None Human 8.2 pKi = 8.2 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 549 11 2 7 5.2 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CC)c1 10.1016/s0960-894x(03)00018-0
CHEMBL12233 39828 0 None None None Human 8.2 pKi = 8.2 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 549 11 2 7 5.2 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(CC)c1 10.1016/s0960-894x(03)00018-0
20747575 198694 0 None None None Human 8.2 pKi = 8.2 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 579 12 2 8 5.0 CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COC)c1 10.1016/s0960-894x(03)00018-0
CHEMBL275545 198694 0 None None None Human 8.2 pKi = 8.2 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 579 12 2 8 5.0 CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COC)c1 10.1016/s0960-894x(03)00018-0
10693607 202766 0 None 354 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 424 10 1 7 3.3 CCOC(c1ccccc1)(c1ccccc1)C(Oc1nc(OC)cc(OC)n1)C(=O)O 10.1021/jm960274q
CHEMBL304778 202766 0 None 354 2 Human 8.2 pKi = 8.2 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 424 10 1 7 3.3 CCOC(c1ccccc1)(c1ccccc1)C(Oc1nc(OC)cc(OC)n1)C(=O)O 10.1021/jm960274q
51002601 120860 0 None 123 2 Mouse 8.1 pKi = 8.1 Binding
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 906 24 2 17 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CNS(=O)(=O)c4ccc(F)cc4)nn3)c2)cc1 10.1021/jm101110w
CHEMBL1672885 120860 0 None 123 2 Mouse 8.1 pKi = 8.1 Binding
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 906 24 2 17 4.2 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CNS(=O)(=O)c4ccc(F)cc4)nn3)c2)cc1 10.1021/jm101110w
51002602 120861 0 None 812 2 Mouse 8.1 pKi = 8.1 Binding
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 751 21 1 15 4.0 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CF)nn3)c2)cc1 10.1021/jm101110w
CHEMBL1672886 120861 0 None 812 2 Mouse 8.1 pKi = 8.1 Binding
Displacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma countingDisplacement of [125I]ET1 from ETA receptor in CD1 Nu/Nu mouse myocardial ventricles membranes after 2 hrs by gamma counting
ChEMBL 751 21 1 15 4.0 COc1ccc(C2(O)OC(=O)C(c3ccc4c(c3)OCO4)=C2Cc2cc(OC)c(OC)c(OCCOCCOCCOCCn3cc(CF)nn3)c2)cc1 10.1021/jm101110w
10549472 19673 0 None None None Human 7.2 pKi = 7.2 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 409 5 1 6 4.7 Cc1nc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)co1 10.1021/jm000105c
CHEMBL106846 19673 0 None None None Human 7.2 pKi = 7.2 Binding
Inhibition of Human Endothelin A receptor expressed in CHO Cells.Inhibition of Human Endothelin A receptor expressed in CHO Cells.
ChEMBL 409 5 1 6 4.7 Cc1nc(-c2ccc(-c3ccccc3S(=O)(=O)Nc3onc(C)c3C)cc2)co1 10.1021/jm000105c
10734431 86746 0 None None None Rat 6.2 pKi = 6.2 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 320 3 1 4 3.1 Cc1noc(NS(=O)(=O)c2ccccc2C(F)(F)F)c1C 10.1021/jm970872k
CHEMBL150697 86746 0 None None None Rat 6.2 pKi = 6.2 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 320 3 1 4 3.1 Cc1noc(NS(=O)(=O)c2ccccc2C(F)(F)F)c1C 10.1021/jm970872k
20747572 40365 0 None None None Human 6.2 pKi = 6.2 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 555 10 2 7 5.3 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(Cl)c1 10.1016/s0960-894x(03)00018-0
CHEMBL12348 40365 0 None None None Human 6.2 pKi = 6.2 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 555 10 2 7 5.3 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(Cl)c1 10.1016/s0960-894x(03)00018-0
19934546 473199 0 None 8 2 Human 5.2 pKi = 5.2 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 466 7 1 4 6.0 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(OCc3cccc4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
CHEMBL86581 473199 0 None 8 2 Human 5.2 pKi = 5.2 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 466 7 1 4 6.0 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(OCc3cccc4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
10718053 97403 0 None 5 2 Rat 5.1 pKi = 5.1 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 442 8 1 6 4.8 CCOC(=O)c1c(C)noc1NS(=O)(=O)c1ccccc1-c1ccc(CC(C)C)cc1 10.1021/jm970872k
CHEMBL151525 97403 0 None 5 2 Rat 5.1 pKi = 5.1 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 442 8 1 6 4.8 CCOC(=O)c1c(C)noc1NS(=O)(=O)c1ccccc1-c1ccc(CC(C)C)cc1 10.1021/jm970872k
10597897 84599 0 None 724 2 Rat 7.1 pKi = 7.1 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 414 7 1 5 5.0 COc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
CHEMBL148853 84599 0 None 724 2 Rat 7.1 pKi = 7.1 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 414 7 1 5 5.0 COc1cc(CC(C)C)ccc1-c1ccccc1S(=O)(=O)Nc1onc(C)c1C 10.1021/jm970872k
10668703 330083 0 None 1230 2 Rat 8.1 pKi = 8.1 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 400 6 2 5 4.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2O)c1C 10.1021/jm970872k
CHEMBL422851 330083 0 None 1230 2 Rat 8.1 pKi = 8.1 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 400 6 2 5 4.7 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2O)c1C 10.1021/jm970872k
44311763 469353 0 None -6 2 Human 8.1 pKi = 8.1 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 610 14 2 7 4.4 CCCCS(=O)(=O)NC(=O)C(CC(C)C)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
CHEMBL72217 469353 0 None -6 2 Human 8.1 pKi = 8.1 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 610 14 2 7 4.4 CCCCS(=O)(=O)NC(=O)C(CC(C)C)NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1 10.1016/s0960-894x(98)00387-4
22574645 41661 0 None None None Human 8.1 pKi = 8.1 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 597 14 2 8 5.1 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COCCF)c1 10.1016/s0960-894x(03)00018-0
CHEMBL12588 41661 0 None None None Human 8.1 pKi = 8.1 Binding
Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1Binding affinity towards human ETA receptor expressed in CHO-K1 cells in the presence of 0.05 nM [125I]-labeled endothelin 1
ChEMBL 597 14 2 8 5.1 CCCc1nc(CC)c(C(N)=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)Nc2onc(C)c2C)c(COCCF)c1 10.1016/s0960-894x(03)00018-0
104865 1454 67 None -1 3 Human 8.1 pKi = 8.1 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm020289q
3494 1454 67 None -1 3 Human 8.1 pKi = 8.1 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm020289q
392 1454 67 None -1 3 Human 8.1 pKi = 8.1 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm020289q
CHEMBL957 1454 67 None -1 3 Human 8.1 pKi = 8.1 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm020289q
DB00559 1454 67 None -1 3 Human 8.1 pKi = 8.1 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm020289q
11071062 199481 0 None None None Human 8.1 pKi = 8.1 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 494 9 1 7 5.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)CC(C)C)c1C 10.1021/jm020289q
CHEMBL281869 199481 0 None None None Human 8.1 pKi = 8.1 Binding
Inhibitory activity against human endothelin A receptor expressed in CHO cellsInhibitory activity against human endothelin A receptor expressed in CHO cells
ChEMBL 494 9 1 7 5.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(-c3ncco3)cc2CN(C)CC(C)C)c1C 10.1021/jm020289q
44311873 469372 0 None -2 2 Human 8.1 pKi = 8.1 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 636 13 2 7 5.0 CCCCS(=O)(=O)NC(=O)C(NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C1CCCCC1 10.1016/s0960-894x(98)00387-4
CHEMBL72358 469372 0 None -2 2 Human 8.1 pKi = 8.1 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 636 13 2 7 5.0 CCCCS(=O)(=O)NC(=O)C(NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C1CCCCC1 10.1016/s0960-894x(98)00387-4
10548904 238259 0 None 380 2 Rat 7.1 pKi = 7.1 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 398 7 1 4 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CCC(C)C)cc2)c1C 10.1021/jm970872k
CHEMBL345551 238259 0 None 380 2 Rat 7.1 pKi = 7.1 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 398 7 1 4 5.3 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CCC(C)C)cc2)c1C 10.1021/jm970872k
10711546 470317 5 None None None Rat 5.1 pKi = 5.1 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle (Endothelin A receptor) was determined by radioligand binding assayAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle (Endothelin A receptor) was determined by radioligand binding assay
ChEMBL 330 3 1 4 2.9 Cc1noc(NS(=O)(=O)c2ccccc2Br)c1C 10.1021/jm970872k
CHEMBL80506 470317 5 None None None Rat 5.1 pKi = 5.1 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle (Endothelin A receptor) was determined by radioligand binding assayAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle (Endothelin A receptor) was determined by radioligand binding assay
ChEMBL 330 3 1 4 2.9 Cc1noc(NS(=O)(=O)c2ccccc2Br)c1C 10.1021/jm970872k
19934535 216630 0 None -7 2 Human 4.1 pKi = 4.1 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 468 6 3 4 5.0 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NC(=O)c3c[nH]c4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
CHEMBL315096 216630 0 None -7 2 Human 4.1 pKi = 4.1 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 468 6 3 4 5.0 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NC(=O)c3c[nH]c4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
104865 1454 67 None -1 3 Human 7.1 pKi = 7.1 Binding
Ability to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cellsAbility to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm000538f
3494 1454 67 None -1 3 Human 7.1 pKi = 7.1 Binding
Ability to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cellsAbility to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm000538f
392 1454 67 None -1 3 Human 7.1 pKi = 7.1 Binding
Ability to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cellsAbility to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm000538f
CHEMBL957 1454 67 None -1 3 Human 7.1 pKi = 7.1 Binding
Ability to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cellsAbility to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm000538f
DB00559 1454 67 None -1 3 Human 7.1 pKi = 7.1 Binding
Ability to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cellsAbility to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cells
ChEMBL 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 10.1021/jm000538f
9949368 84809 0 None None None Human 6.1 pKi = 6.1 Binding
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 329 4 1 5 3.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccn2)c1C 10.1021/jm970872k
CHEMBL149018 84809 0 None None None Human 6.1 pKi = 6.1 Binding
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 329 4 1 5 3.2 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccn2)c1C 10.1021/jm970872k
44320537 216793 0 None None None Human 4.1 pKi = 4.1 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 479 6 2 4 5.7 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NC(=O)c3cccc4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
CHEMBL316247 216793 0 None None None Human 4.1 pKi = 4.1 Binding
Affinity against ET A receptorAffinity against ET A receptor
ChEMBL 479 6 2 4 5.7 CCCN1c2ccccc2C(=O)N(CC(=O)O)c2cc(NC(=O)c3cccc4ccccc34)ccc21 10.1016/0960-894X(95)00019-P
44311810 203080 5 None -6 2 Human 6.1 pKi = 6.1 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
44312023 203080 5 None -6 2 Human 6.1 pKi = 6.1 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
9830098 203080 5 None -6 2 Human 6.1 pKi = 6.1 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
9938533 203080 5 None -6 2 Human 6.1 pKi = 6.1 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
CHEMBL307033 203080 5 None -6 2 Human 6.1 pKi = 6.1 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
CHEMBL310919 203080 5 None -6 2 Human 6.1 pKi = 6.1 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
CHEMBL311854 203080 5 None -6 2 Human 6.1 pKi = 6.1 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
CHEMBL72295 203080 5 None -6 2 Human 6.1 pKi = 6.1 Binding
Compound was tested for the binding affinity against Endothelin A receptorCompound was tested for the binding affinity against Endothelin A receptor
ChEMBL 596 13 2 7 4.0 CCCCS(=O)(=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)C 10.1016/s0960-894x(98)00388-6
10814297 468537 0 None 17 2 Human 7.1 pKi = 7.1 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 472 10 1 7 4.3 COc1cc(OC)nc(OC(C(=O)O)C(Oc2ccccc2)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
CHEMBL66402 468537 0 None 17 2 Human 7.1 pKi = 7.1 Binding
Binding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cellsBinding affinity towards human Endothelin A receptor by measuring its ability to displace [125I]ET1 from CHO cells
ChEMBL 472 10 1 7 4.3 COc1cc(OC)nc(OC(C(=O)O)C(Oc2ccccc2)(c2ccccc2)c2ccccc2)n1 10.1021/jm960274q
44311852 203133 0 None -144 2 Human 7.1 pKi = 7.1 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 579 10 3 4 6.0 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3cccs3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
CHEMBL307470 203133 0 None -144 2 Human 7.1 pKi = 7.1 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 579 10 3 4 6.0 Cc1cc(C)cc(C(=O)N(C)[C@H](Cc2ccc(-c3cccs3)cc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)c1 10.1016/s0960-894x(98)00387-4
9818889 239754 0 None None None Human 5.1 pKi = 5.1 Binding
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 330 4 1 6 2.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ncccn2)c1C 10.1021/jm970872k
CHEMBL357678 239754 0 None None None Human 5.1 pKi = 5.1 Binding
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 330 4 1 6 2.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ncccn2)c1C 10.1021/jm970872k
10742502 239874 0 None 134 2 Rat 7.1 pKi = 7.1 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 457 9 3 6 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NCC(=O)O)c1C 10.1021/jm970872k
CHEMBL357823 239874 0 None 134 2 Rat 7.1 pKi = 7.1 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 457 9 3 6 4.5 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccc(CC(C)C)cc2NCC(=O)O)c1C 10.1021/jm970872k
44311858 196939 0 None -2 2 Human 8.0 pKi = 8.0 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 598 13 3 8 2.8 CCCCS(=O)(=O)NC(=O)C(NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)O 10.1016/s0960-894x(98)00387-4
CHEMBL263301 196939 0 None -2 2 Human 8.0 pKi = 8.0 Binding
Binding affinity to Endothelin A receptorBinding affinity to Endothelin A receptor
ChEMBL 598 13 3 8 2.8 CCCCS(=O)(=O)NC(=O)C(NC(=O)[C@@H](Cc1ccc(-c2ccno2)cc1)N(C)C(=O)c1cc(C)cc(C)c1)C(C)O 10.1016/s0960-894x(98)00387-4
10257882 7409 51 None -7 2 Human 8.0 pKi = 8.0 Binding
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm300682j
8448 7409 51 None -7 2 Human 8.0 pKi = 8.0 Binding
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm300682j
CHEMBL539423 7409 51 None -7 2 Human 8.0 pKi = 8.0 Binding
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm300682j
DB12548 7409 51 None -7 2 Human 8.0 pKi = 8.0 Binding
Binding affinity to ETA receptorBinding affinity to ETA receptor
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm300682j
10257882 7409 51 None -7 2 Human 8.0 pKi = 8.0 Binding
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm058225d
8448 7409 51 None -7 2 Human 8.0 pKi = 8.0 Binding
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm058225d
CHEMBL539423 7409 51 None -7 2 Human 8.0 pKi = 8.0 Binding
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm058225d
DB12548 7409 51 None -7 2 Human 8.0 pKi = 8.0 Binding
Inhibitory concentration against endothelin receptor type AInhibitory concentration against endothelin receptor type A
ChEMBL 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 10.1021/jm058225d
9840391 214256 4 None None None Rat 7.1 pKi = 7.1 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 328 4 1 4 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1C 10.1021/jm970872k
CHEMBL310427 214256 4 None None None Rat 7.1 pKi = 7.1 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 328 4 1 4 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccccc2)c1C 10.1021/jm970872k
9840650 97657 0 None None None Human 6.1 pKi = 6.1 Binding
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 334 4 1 5 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccsc2)c1C 10.1021/jm970872k
CHEMBL151819 97657 0 None None None Human 6.1 pKi = 6.1 Binding
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 334 4 1 5 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2ccsc2)c1C 10.1021/jm970872k
9927658 239826 0 None None None Human 6.0 pKi = 6.0 Binding
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 334 4 1 5 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2cccs2)c1C 10.1021/jm970872k
CHEMBL357789 239826 0 None None None Human 6.0 pKi = 6.0 Binding
Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.Ability to inhibit Endothelin A receptor induced contractions in rabbit carotid artery rings (ETA) was determined in an in vitro functional assay.
ChEMBL 334 4 1 5 3.8 Cc1noc(NS(=O)(=O)c2ccccc2-c2cccs2)c1C 10.1021/jm970872k
44314820 311655 0 None -380 2 Pig 7.0 pKi = 7.0 Binding
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1518 45 18 17 1.0 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
77282210 311655 0 None -380 2 Pig 7.0 pKi = 7.0 Binding
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1518 45 18 17 1.0 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
CHEMBL405377 311655 0 None -380 2 Pig 7.0 pKi = 7.0 Binding
Ability to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluatedAbility to inhibit [125I]ET1 binding to the Endothelin A receptor from porcine lung membranes was evaluated
ChEMBL 1518 45 18 17 1.0 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)CCC(=O)O)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 10.1016/0960-894X(96)00421-0
10737908 84872 0 None 102 2 Rat 6.0 pKi = 6.0 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 370 6 1 4 4.6 Cc1cnoc1NS(=O)(=O)c1ccccc1-c1ccc(CC(C)C)cc1 10.1021/jm970872k
CHEMBL149060 84872 0 None 102 2 Rat 6.0 pKi = 6.0 Binding
Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorAbility to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptor
ChEMBL 370 6 1 4 4.6 Cc1cnoc1NS(=O)(=O)c1ccccc1-c1ccc(CC(C)C)cc1 10.1021/jm970872k
2527 333383 75 None None None Rat 8.4 pIC50 = 8.4 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 None
5340 333383 75 None None None Rat 8.4 pIC50 = 8.4 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 None
CHEMBL437 333383 75 None None None Rat 8.4 pIC50 = 8.4 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 None
DB06147 333383 75 None None None Rat 8.4 pIC50 = 8.4 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 255 3 2 5 1.5 Nc1ccc(S(=O)(=O)Nc2nccs2)cc1 None
2514 334052 77 None None None Rat 8.3 pIC50 = 8.3 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 None
5329 334052 77 None None None Rat 8.3 pIC50 = 8.3 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 None
CHEMBL443 334052 77 None None None Rat 8.3 pIC50 = 8.3 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 None
DB01015 334052 77 None None None Rat 8.3 pIC50 = 8.3 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 253 3 2 5 1.4 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 None
4458 38359 47 None None None Rat 8.2 pIC50 = 8.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 309 3 1 6 1.6 CC(=O)N(c1onc(C)c1C)S(=O)(=O)c1ccc(N)cc1 None
6662 38359 47 None None None Rat 8.2 pIC50 = 8.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 309 3 1 6 1.6 CC(=O)N(c1onc(C)c1C)S(=O)(=O)c1ccc(N)cc1 None
CHEMBL1200910 38359 47 None None None Rat 8.2 pIC50 = 8.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 309 3 1 6 1.6 CC(=O)N(c1onc(C)c1C)S(=O)(=O)c1ccc(N)cc1 None
DB14033 38359 47 None None None Rat 8.2 pIC50 = 8.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 309 3 1 6 1.6 CC(=O)N(c1onc(C)c1C)S(=O)(=O)c1ccc(N)cc1 None
2529 347569 76 None None None Rat 8.2 pIC50 = 8.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C None
5344 347569 76 None None None Rat 8.2 pIC50 = 8.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C None
CHEMBL453 347569 76 None None None Rat 8.2 pIC50 = 8.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C None
DB00263 347569 76 None None None Rat 8.2 pIC50 = 8.2 Binding
Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.
Drug Central 267 3 2 5 1.7 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C None
104865 1454 67 None None None Pig 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
3494 1454 67 None None None Pig 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
392 1454 67 None None None Pig 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
CHEMBL957 1454 67 None None None Pig 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
DB00559 1454 67 None None None Pig 8.1 pIC50 = 8.1 Binding
In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.In vitro inhibition of [125 I]ET-1 binding to Endothelin A receptor in porcine aortic membrane.
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
16004692 4984 61 None None None Human 8.0 pIC50 = 8.0 Binding
IC50 value as determined in binding assays using membranes of Chinese hamster ovary (CHO) cells containing recombinant ETAIC50 value as determined in binding assays using membranes of Chinese hamster ovary (CHO) cells containing recombinant ETA
Drug Central 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br None
4809 4984 61 None None None Human 8.0 pIC50 = 8.0 Binding
IC50 value as determined in binding assays using membranes of Chinese hamster ovary (CHO) cells containing recombinant ETAIC50 value as determined in binding assays using membranes of Chinese hamster ovary (CHO) cells containing recombinant ETA
Drug Central 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br None
7352 4984 61 None None None Human 8.0 pIC50 = 8.0 Binding
IC50 value as determined in binding assays using membranes of Chinese hamster ovary (CHO) cells containing recombinant ETAIC50 value as determined in binding assays using membranes of Chinese hamster ovary (CHO) cells containing recombinant ETA
Drug Central 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br None
CHEMBL2103873 4984 61 None None None Human 8.0 pIC50 = 8.0 Binding
IC50 value as determined in binding assays using membranes of Chinese hamster ovary (CHO) cells containing recombinant ETAIC50 value as determined in binding assays using membranes of Chinese hamster ovary (CHO) cells containing recombinant ETA
Drug Central 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br None
DB08932 4984 61 None None None Human 8.0 pIC50 = 8.0 Binding
IC50 value as determined in binding assays using membranes of Chinese hamster ovary (CHO) cells containing recombinant ETAIC50 value as determined in binding assays using membranes of Chinese hamster ovary (CHO) cells containing recombinant ETA
Drug Central 586 11 2 8 3.6 CCCNS(=O)(=O)Nc1ncnc(c1c1ccc(cc1)Br)OCCOc1ncc(cn1)Br None
14322 3648 0 None None None Human 8.1 pKd = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 30992315
1003 7888 0 None None None Human 8.5 pKd = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 612 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)C(C(=O)O)[3H])C(C)C)C 7768260
70686617 7888 0 None None None Human 8.5 pKd = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 612 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)C(C(=O)O)[3H])C(C)C)C 7768260
CHEMBL2067984 7888 0 None None None Human 8.5 pKd = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 612 7 6 6 0.8 CC(C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@H](NC1=O)Cc1c[nH]c2c1cccc2)C(C(=O)O)[3H])C(C)C)C 7768260
10605470 6174 0 None None None Human 9.0 pKd = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 823 17 3 10 6.2 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)O)/Cc1cc(OCCCC(=O)NCCc2ccc(c(c2)I)O)c(c(c1)OC)OC 9489609
3519 6174 0 None None None Human 9.0 pKd = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 823 17 3 10 6.2 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)O)/Cc1cc(OCCCC(=O)NCCc2ccc(c(c2)I)O)c(c(c1)OC)OC 9489609
CHEMBL2068816 6174 0 None None None Human 9.0 pKd = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 823 17 3 10 6.2 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)O)/Cc1cc(OCCCC(=O)NCCc2ccc(c(c2)I)O)c(c(c1)OC)OC 9489609
1001 7736 0 None None None Human 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 619 12 5 6 3.7 CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccc(cc1)O)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C 8012722
132991 7736 0 None None None Human 9.1 pKd = 9.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 619 12 5 6 3.7 CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccc(cc1)O)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C 8012722
3479 8048 0 None None None Human 9.2 pKd = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 727 8 2 9 5.3 O=C(OC[C@@]12CC[C@@]3([C@H](C1=CCC1[C@@]2(C)CCC2[C@]1(C)CCC(=O)C2(C)C)CC(CC3)(C)C)C(=O)[O-])/C=C/c1cc(O)ccc1NC(=O)/C=C/C(=O)[O-] 9548403
73755056 8048 0 None None None Human 9.2 pKd = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 727 8 2 9 5.3 O=C(OC[C@@]12CC[C@@]3([C@H](C1=CCC1[C@@]2(C)CCC2[C@]1(C)CCC(=O)C2(C)C)CC(CC3)(C)C)C(=O)[O-])/C=C/c1cc(O)ccc1NC(=O)/C=C/C(=O)[O-] 9548403
23670447 6168 2 None None None Human 9.4 pKd = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 9023329
9871594 6168 2 None None None Human 9.4 pKd = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 9023329
999 6168 2 None None None Human 9.4 pKd = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 9023329
CHEMBL1204799 6168 2 None None None Human 9.4 pKd = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 9023329
CHEMBL25438 6168 2 None None None Human 9.4 pKd = 9.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 528 10 0 9 0.1 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)[O-])/Cc1cc(OC)c(c(c1)OC)OC.[Na+] 9023329
1002 7737 0 None None None Human 9.7 pKd = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 821 17 3 10 6.2 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)O)/Cc1cc(OCCCC(=O)NCCc2ccc(c(c2)[125I])O)c(c(c1)OC)OC 9489609
10605470 7737 0 None None None Human 9.7 pKd = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 821 17 3 10 6.2 COc1ccc(cc1)C(=O)/C(=C(/c1ccc2c(c1)OCO2)\C(=O)O)/Cc1cc(OCCCC(=O)NCCc2ccc(c(c2)[125I])O)c(c(c1)OC)OC 9489609
994 7831 0 None None None Human 8.2 pKd None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12193043
155817386 7655 0 None None None Human 9.0 pKd None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 2549 78 37 35 -4.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CS)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 8851522
992 7655 0 None None None Human 9.0 pKd None 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 2549 78 37 35 -4.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CS)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 8851522
44284383 7763 0 None None None Human 9.7 pKd None 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8851522
993 7763 0 None None None Human 9.7 pKd None 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8851522
16172435 7654 0 None 1 2 Human 9.8 pKd None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 2494 79 36 36 -5.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CS)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 7524189
16172435 7654 0 None 1 2 Human 9.8 pKd None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 2494 79 36 36 -5.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CS)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 7620699
16172435 7654 0 None 1 2 Human 9.8 pKd None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 2494 79 36 36 -5.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CS)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 8355464
991 7654 0 None 1 2 Human 9.8 pKd None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 2494 79 36 36 -5.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CS)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 7524189
991 7654 0 None 1 2 Human 9.8 pKd None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 2494 79 36 36 -5.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CS)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 7620699
991 7654 0 None 1 2 Human 9.8 pKd None 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 2494 79 36 36 -5.8 CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CS)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC 8355464
176 823 54 None -7 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
2157 823 54 None -7 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
2566 823 54 None -7 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
CHEMBL633 823 54 None -7 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
DB01118 823 54 None -7 31 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
Drug Central 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 None
1481 4225 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to ETA receptorBinding affinity to ETA receptor
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
3749 4225 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to ETA receptorBinding affinity to ETA receptor
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
589 4225 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to ETA receptorBinding affinity to ETA receptor
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
CHEMBL1513 4225 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to ETA receptorBinding affinity to ETA receptor
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
DB01029 4225 0 None 1 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to ETA receptorBinding affinity to ETA receptor
Drug Central 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 None
3219 369899 38 None None None Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
Drug Central 372 4 1 3 4.0 CC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc(S(C)(=O)=O)cc1 None
5472495 369899 38 None None None Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
Drug Central 372 4 1 3 4.0 CC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc(S(C)(=O)=O)cc1 None
CHEMBL488025 369899 38 None None None Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
Drug Central 372 4 1 3 4.0 CC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc(S(C)(=O)=O)cc1 None
DB06246 369899 38 None None None Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)DRUGMATRIX: Endothelin ETA radioligand binding (ligand: [125I] Endothelin-1)
Drug Central 372 4 1 3 4.0 CC1=C(CC(=O)O)c2cc(F)ccc2/C1=C\c1ccc(S(C)(=O)=O)cc1 None
104865 1454 67 None -1 3 Human 8.1 pKi = 8.1 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
3494 1454 67 None -1 3 Human 8.1 pKi = 8.1 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
392 1454 67 None -1 3 Human 8.1 pKi = 8.1 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
CHEMBL957 1454 67 None -1 3 Human 8.1 pKi = 8.1 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
DB00559 1454 67 None -1 3 Human 8.1 pKi = 8.1 Binding
Ability to displace endothelin ([125I]ET1) from human Endothelin A receptorAbility to displace endothelin ([125I]ET1) from human Endothelin A receptor
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
104865 1454 67 None 1 3 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
3494 1454 67 None 1 3 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
392 1454 67 None 1 3 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
CHEMBL957 1454 67 None 1 3 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
DB00559 1454 67 None 1 3 Rat 8.1 pKi = 8.1 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
Drug Central 551 10 2 10 4.2 OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccn1 None
216235 7338 38 None 1 2 Human 8.0 pKi = 8.0 Binding
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
Drug Central 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C None
3548 7338 38 None 1 2 Human 8.0 pKi = 8.0 Binding
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
Drug Central 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C None
3950 7338 38 None 1 2 Human 8.0 pKi = 8.0 Binding
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
Drug Central 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C None
CHEMBL282724 7338 38 None 1 2 Human 8.0 pKi = 8.0 Binding
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
Drug Central 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C None
DB06268 7338 38 None 1 2 Human 8.0 pKi = 8.0 Binding
Binding affinity against human Endothelin A receptorBinding affinity against human Endothelin A receptor
Drug Central 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C None
216235 7338 38 None -1 2 Rat 8.0 pKi = 8.0 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
Drug Central 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C None
3548 7338 38 None -1 2 Rat 8.0 pKi = 8.0 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
Drug Central 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C None
3950 7338 38 None -1 2 Rat 8.0 pKi = 8.0 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
Drug Central 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C None
CHEMBL282724 7338 38 None -1 2 Rat 8.0 pKi = 8.0 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
Drug Central 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C None
DB06268 7338 38 None -1 2 Rat 8.0 pKi = 8.0 Binding
Binding affinity towards Endothelin A receptorBinding affinity towards Endothelin A receptor
Drug Central 454 6 1 8 4.0 O=C(c1sccc1S(=O)(=O)Nc1onc(c1Cl)C)Cc1cc2OCOc2cc1C None
197712 807 76 None 11 2 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 None
3951 807 76 None 11 2 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 None
4337 807 76 None 11 2 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 None
6918493 807 76 None 11 2 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 None
CHEMBL1111 807 76 None 11 2 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 None
CHEMBL302753 807 76 None 11 2 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 None
DB06403 807 76 None 11 2 Human 8.0 pKi = 8.0 Binding
NoneNone
Drug Central 378 7 1 5 3.5 COC([C@@H](C(=O)O)Oc1nc(C)cc(n1)C)(c1ccccc1)c1ccccc1 None
12286 1953 39 None 1348 2 Human 9.9 pKi = 9.9 Binding
Binding affinity measured as displacement of ET-1 from CHO cells expressing hET<sub>A</sub>Binding affinity measured as displacement of ET-1 from CHO cells expressing hET<sub>A</sub>
Guide to Pharmacology 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 9703472
6433095 1953 39 None 1348 2 Human 9.9 pKi = 9.9 Binding
Binding affinity measured as displacement of ET-1 from CHO cells expressing hET<sub>A</sub>Binding affinity measured as displacement of ET-1 from CHO cells expressing hET<sub>A</sub>
Guide to Pharmacology 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 9703472
CHEMBL109648 1953 39 None 1348 2 Human 9.9 pKi = 9.9 Binding
Binding affinity measured as displacement of ET-1 from CHO cells expressing hET<sub>A</sub>Binding affinity measured as displacement of ET-1 from CHO cells expressing hET<sub>A</sub>
Guide to Pharmacology 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 9703472
DB06677 1953 39 None 1348 2 Human 9.9 pKi = 9.9 Binding
Binding affinity measured as displacement of ET-1 from CHO cells expressing hET<sub>A</sub>Binding affinity measured as displacement of ET-1 from CHO cells expressing hET<sub>A</sub>
Guide to Pharmacology 577 11 3 13 2.4 Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC 9703472
159594 1080 38 None 1 3 Human 10.5 pKi = 10.5 Binding
CHO cells expressing human ET<sub>A</sub> receptor.CHO cells expressing human ET<sub>A</sub> receptor.
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8632312
159594 1080 38 None 1 3 Human 10.5 pKi = 10.5 Binding
CHO cells expressing human ET<sub>A</sub> receptor.CHO cells expressing human ET<sub>A</sub> receptor.
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8676339
3487 1080 38 None 1 3 Human 10.5 pKi = 10.5 Binding
CHO cells expressing human ET<sub>A</sub> receptor.CHO cells expressing human ET<sub>A</sub> receptor.
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8632312
3487 1080 38 None 1 3 Human 10.5 pKi = 10.5 Binding
CHO cells expressing human ET<sub>A</sub> receptor.CHO cells expressing human ET<sub>A</sub> receptor.
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8676339
CHEMBL9194 1080 38 None 1 3 Human 10.5 pKi = 10.5 Binding
CHO cells expressing human ET<sub>A</sub> receptor.CHO cells expressing human ET<sub>A</sub> receptor.
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8632312
CHEMBL9194 1080 38 None 1 3 Human 10.5 pKi = 10.5 Binding
CHO cells expressing human ET<sub>A</sub> receptor.CHO cells expressing human ET<sub>A</sub> receptor.
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8676339
DB06199 1080 38 None 1 3 Human 10.5 pKi = 10.5 Binding
CHO cells expressing human ET<sub>A</sub> receptor.CHO cells expressing human ET<sub>A</sub> receptor.
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8632312
DB06199 1080 38 None 1 3 Human 10.5 pKi = 10.5 Binding
CHO cells expressing human ET<sub>A</sub> receptor.CHO cells expressing human ET<sub>A</sub> receptor.
Guide to Pharmacology 510 12 1 6 4.7 CCCCN(C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)OC)C(=O)O)c1ccc2c(c1)OCO2)CCCC 8676339
13015 3149 30 None None None Human 11.0 pKi = 11 Binding
UnclassifiedUnclassified
Guide to Pharmacology 536 8 1 7 5.8 CC1=C(ON=C1NS(=O)(=O)C2=CC=CC=C2C3=C(C=C(C=C3)C4=NC=CO4)CN(C)C(=O)CC(C)(C)C)C 12502366
156690 3149 30 None None None Human 11.0 pKi = 11 Binding
UnclassifiedUnclassified
Guide to Pharmacology 536 8 1 7 5.8 CC1=C(ON=C1NS(=O)(=O)C2=CC=CC=C2C3=C(C=C(C=C3)C4=NC=CO4)CN(C)C(=O)CC(C)(C)C)C 12502366
CHEMBL383581 3149 30 None None None Human 11.0 pKi = 11 Binding
UnclassifiedUnclassified
Guide to Pharmacology 536 8 1 7 5.8 CC1=C(ON=C1NS(=O)(=O)C2=CC=CC=C2C3=C(C=C(C=C3)C4=NC=CO4)CN(C)C(=O)CC(C)(C)C)C 12502366
10257882 7409 51 None -7 2 Human 8.0 pKi = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 16220969
8448 7409 51 None -7 2 Human 8.0 pKi = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 16220969
CHEMBL539423 7409 51 None -7 2 Human 8.0 pKi = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 16220969
DB12548 7409 51 None -7 2 Human 8.0 pKi = 8.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 592 12 1 7 6.5 CCCCC1=NC2(C(=O)N1Cc1ccc(c(c1)COCC)c1ccccc1S(=O)(=O)Nc1noc(c1C)C)CCCC2 16220969
13016 1378 15 None 1 4 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10956219
9843631 1378 15 None 1 4 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10956219
CHEMBL24461 1378 15 None 1 4 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 395 5 1 6 4.4 CC1=C(ON=C1C)NS(=O)(=O)C2=CC=CC=C2C3=CC=C(C=C3)C4=NC=CO4 10956219
177236 2734 40 None 2 3 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 8667356
3508 2734 40 None 2 3 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 8667356
9931375 2734 40 None 2 3 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 8667356
9953358 2734 40 None 2 3 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 8667356
CHEMBL23261 2734 40 None 2 3 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 8667356
CHEMBL25344 2734 40 None 2 3 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 8667356
CHEMBL5687038 2734 40 None 2 3 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 8667356
DB04883 2734 40 None 2 3 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 410 9 1 7 2.9 COC([C@@H](C(=O)O)Oc1nc(OC)cc(n1)OC)(c1ccccc1)c1ccccc1 8667356
14516 397 1 None 6 2 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 12193066
9916235 397 1 None 6 2 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 12193066
CHEMBL111277 397 1 None 6 2 Human 9.7 pKi = 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 578 14 1 7 4.6 CCCCCS(=O)(=O)N(CCC)CCN1C[C@@H]([C@H]([C@@H]1C2=CC(=C(C=C2)OC)F)C(=O)O)C3=CC4=C(C=C3)OCO4 12193066