VU0506013


SMILES CC1=CC=CC=C1OCC(=O)NC2=CC(=CN(C2=O)C)C(=O)N3CCCC3
InChIKey HDESYZHTQAEDLX-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 369.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
Y4 NPY4R Human Neuropeptide Y A pKi 8.36 8.36 8.36 ChEMBL
Y4 NPY4R Human Neuropeptide Y A pKd 7.51 7.51 7.51 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
Y4 NPY4R Human Neuropeptide Y A pEC50 6.9 6.9 6.9 Guide to Pharmacology
Y4 NPY4R Rat Neuropeptide Y A pEC50 9.51 9.51 9.51 ChEMBL
Y4 NPY4R Human Neuropeptide Y A pEC50 6.9 8.1 10.51 ChEMBL
Y1 NPY1R Human Neuropeptide Y A pEC50 10.32 10.32 10.32 ChEMBL
Y2 NPY2R Human Neuropeptide Y A pEC50 10.79 10.79 10.79 ChEMBL
Y5 NPY5R Human Neuropeptide Y A pEC50 8.73 8.73 8.73 ChEMBL
Y4 NPY4R Mouse Neuropeptide Y A pEC50 10.15 10.15 10.15 ChEMBL