volinanserin


SMILES COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O
InChIKey HXTGXYRHXAGCFP-OAQYLSRUSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 373.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.5 7.6 7.7 Guide to Pharmacology
α2B ADA2B Human Adrenoceptors A pKi 5.89 5.89 5.89 ChEMBL
H1 HRH1 Human Histamine A pKi 6.0 6.44 6.88 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.07 6.07 6.07 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.9 5.9 5.9 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.5 7.35 7.89 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.82 9.41 10.0 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKd 9.85 9.85 9.85 ChEMBL
κ OPRK Human Opioid A pKi 6.99 6.99 6.99 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.65 5.83 5.89 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 5.42 5.42 5.42 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 6.5 7.9 9.3 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 8.32 8.32 8.32 ChEMBL