tolterodine


SMILES Cc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)O
InChIKey OOGJQPCLVADCPB-HXUWFJFHSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 325.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.4 8.45 8.5 Guide to Pharmacology
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.4 8.45 8.5 Guide to Pharmacology
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.4 8.45 8.5 Guide to Pharmacology
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.3 8.35 8.4 Guide to Pharmacology
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.5 8.65 8.8 Guide to Pharmacology
M5 ACM5 Rat Acetylcholine (muscarinic) A pKi 8.66 8.66 8.66 ChEMBL
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 8.15 8.29 8.44 ChEMBL
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 8.16 8.37 8.57 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.41 8.54 8.66 ChEMBL
H1 HRH1 Human Histamine A pKi 6.89 6.89 6.89 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.51 8.51 8.51 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 7.86 8.33 8.49 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKd 7.8 7.8 7.8 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 7.88 8.28 8.57 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.06 8.46 8.85 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.05 8.05 8.05 Drug Central
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.07 8.07 8.07 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.07 8.07 8.07 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.07 8.07 8.07 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.06 8.06 8.06 Drug Central
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 8.07 8.07 8.07 Drug Central
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 8.09 8.09 8.09 Drug Central
M5 ACM5 Rat Acetylcholine (muscarinic) A pKi 8.06 8.06 8.06 Drug Central
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 8.05 8.05 8.05 Drug Central
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 8.09 8.09 8.09 Drug Central
M4 ACM4 Rat Acetylcholine (muscarinic) A pKi 8.51 8.51 8.51 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 8.85 8.85 8.85 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CX3CR1 CX3C1 Human Chemokine A pEC50 5.43 5.43 5.43 ChEMBL
FFA4 FFAR4 Human Free fatty acid A pEC50 5.36 5.36 5.36 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pIC50 6.36 6.36 6.36 ChEMBL
β2 ADRB2 Human Adrenoceptors A pEC50 5.41 5.41 5.41 ChEMBL