amisulpride


SMILES CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC
InChIKey NTJOBXMMWNYJFB-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 7
Molecular weight (Da) 369.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations D2 D4

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Human Dopamine A pKi 7.9 7.88 8.0 Guide to Pharmacology
D3 DRD3 Rat Dopamine A pKi 7.4 7.4 7.4 Guide to Pharmacology
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.6 7.77 7.94 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.9 8.21 8.52 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 8.24 8.24 8.24 Drug Central
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.23 8.23 8.23 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.29 8.29 8.29 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.1 8.1 8.1 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.27 8.27 8.27 Drug Central
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.1 8.1 8.1 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.23 8.23 8.23 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.24 8.24 8.24 Drug Central
D2 DRD2 Human Dopamine A pKi 8.07 8.07 8.07 Drug Central
D3 DRD3 Human Dopamine A pKi 8.07 8.07 8.07 Drug Central
D4 DRD4 Human Dopamine A pKi 8.25 8.25 8.25 Drug Central
D3 DRD3 Rat Dopamine A pKi 8.13 8.13 8.13 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.2 6.2 6.2 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.5 7.2 7.89 ChEMBL
D3 DRD3 Human Dopamine A pKi 8.4 8.43 8.46 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
TSH TSHR Human Glycoprotein hormone A Potency 4.4 4.4 4.4 ChEMBL
D2 DRD2 Human Dopamine A pIC50 7.89 8.37 8.82 ChEMBL