TFMPP


SMILES FC(c1cccc(c1)N1CCNCC1)(F)F
InChIKey KKIMDKMETPPURN-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Molecular weight (Da) 230.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations 5-HT2A 5-HT2C

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.2 6.55 6.9 Guide to Pharmacology
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 7.1 7.15 7.2 Guide to Pharmacology
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.2 5.3 5.4 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.5 7.5 7.5 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.2 7.2 7.2 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.5 7.15 7.8 Guide to Pharmacology
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.4 6.4 6.4 Guide to Pharmacology
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 6.3 6.3 6.3 Guide to Pharmacology
5-HT7 5HT7R Mouse 5-Hydroxytryptamine A pKi 6.3 6.3 6.3 Guide to Pharmacology
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 6.3 6.45 6.6 Guide to Pharmacology
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 7.1 7.1 7.1 Guide to Pharmacology
5-HT5A 5HT5A Mouse 5-Hydroxytryptamine A pKi 5.6 5.6 5.6 Guide to Pharmacology
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 6.53 7.41 8.65 ChEMBL
D2 DRD2 Rat Dopamine A pKi 6.28 6.28 6.28 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.71 6.62 7.09 ChEMBL
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pIC50 7.29 7.43 7.57 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pIC50 6.21 6.21 6.21 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 6.54 6.54 6.54 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 6.82 6.82 6.82 ChEMBL