[3H]SB269970


SMILES CC1CCN(CC1)CC[C@H]1CCCN1S(=O)(=O)c1cccc(c1)O
InChIKey HWKROQUZSKPIKQ-MRXNPFEDSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 5
Molecular weight (Da) 352.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKd 8.92 8.92 8.92 Guide to Pharmacology
5-HT7 5HT7R Guinea pig 5-Hydroxytryptamine A pKd 7.48 7.89 8.4 ChEMBL
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 7.19 7.72 9.11 ChEMBL
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.5 8.47 9.0 ChEMBL
5-HT4 5HT4R Human 5-Hydroxytryptamine A pKi 5.9 5.9 5.9 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.77 5.88 6.0 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 6.51 6.51 6.51 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 5.76 5.76 5.76 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.72 9.09 9.47 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKd 8.01 8.01 8.01 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 5.93 5.93 5.93 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.2 5.2 5.2 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.0 6.65 8.3 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.04 5.04 5.04 ChEMBL
D3 DRD3 Human Dopamine A pKi 5.6 5.92 6.25 ChEMBL
κ OPRK Human Opioid A pKi 6.35 6.35 6.35 ChEMBL
μ OPRM Human Opioid A pKi 6.73 6.73 6.73 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.5 6.5 6.5 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.8 5.8 5.8 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pIC50 8.43 8.83 9.3 ChEMBL
NPS NPSR1 Human Neuropeptide S A Potency 4.9 4.9 4.9 ChEMBL