[3H]PGE2


SMILES CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O
InChIKey XEYBRNLFEZDVAW-ARSRFYASSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 12
Molecular weight (Da) 352.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP1 PE2R1 Human Prostanoid A pKd 7.6 7.75 7.9 Guide to Pharmacology
EP2 PE2R2 Human Prostanoid A pKd 7.7 7.8 7.9 Guide to Pharmacology
EP4 PE2R4 Human Prostanoid A pKd 7.62 8.57 9.52 Guide to Pharmacology
EP3 PE2R3 Rat Prostanoid A pKd 9.1 9.1 9.1 Guide to Pharmacology
EP1 PE2R1 Rat Prostanoid A pKd 7.3 7.45 7.6 Guide to Pharmacology
EP2 PE2R2 Rat Prostanoid A pKd 7.8 8.05 8.3 Guide to Pharmacology
EP4 PE2R4 Rat Prostanoid A pKd 9.0 9.0 9.0 Guide to Pharmacology
EP2 PE2R2 Mouse Prostanoid A pKd 7.7 7.7 7.7 Guide to Pharmacology
EP2 PE2R2 Mouse Prostanoid A pKi 7.66 7.66 7.66 ChEMBL
EP3 PE2R3 Mouse Prostanoid A pKi 8.3 8.3 8.3 ChEMBL
EP1 PE2R1 Human Prostanoid A pKi 7.75 7.94 8.04 ChEMBL
EP3 PE2R3 Human Prostanoid A pKi 8.3 8.98 9.48 ChEMBL
EP2 PE2R2 Human Prostanoid A pKi 7.42 8.35 8.99 ChEMBL
EP4 PE2R4 Human Prostanoid A pKi 8.51 9.27 9.96 ChEMBL
EP3 PE2R3 Human Prostanoid A pKd 8.2 8.85 9.5 Guide to Pharmacology
EP1 PE2R1 Mouse Prostanoid A pKi 8.22 8.22 8.22 ChEMBL
EP4 PE2R4 Mouse Prostanoid A pKi 8.51 8.51 8.51 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP2 PE2R2 Rat Prostanoid A pEC50 7.72 8.71 9.7 ChEMBL
EP2 PE2R2 Rat Prostanoid A pIC50 8.28 8.28 8.28 ChEMBL
EP4 PE2R4 Rat Prostanoid A pEC50 8.46 8.8 9.15 ChEMBL
EP4 PE2R4 Rat Prostanoid A pIC50 8.68 8.68 8.68 ChEMBL
EP1 PE2R1 Human Prostanoid A pEC50 8.43 8.43 8.43 ChEMBL
EP1 PE2R1 Human Prostanoid A pIC50 8.96 8.96 8.96 ChEMBL
FP PF2R Human Prostanoid A pEC50 6.6 6.6 6.6 ChEMBL
EP3 PE2R3 Human Prostanoid A pEC50 8.6 8.6 8.6 ChEMBL
EP3 PE2R3 Human Prostanoid A pIC50 9.03 9.03 9.03 ChEMBL
EP2 PE2R2 Human Prostanoid A pIC50 7.42 8.36 8.66 ChEMBL
EP2 PE2R2 Human Prostanoid A pEC50 6.46 7.71 8.72 ChEMBL
EP4 PE2R4 Human Prostanoid A pIC50 8.0 8.87 9.49 ChEMBL
EP4 PE2R4 Human Prostanoid A pEC50 8.12 9.02 10.7 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 8.0 8.0 8.0 ChEMBL
IP PI2R Human Prostanoid A pEC50 6.46 6.46 6.46 ChEMBL
IP PI2R Human Prostanoid A pIC50 6.58 6.58 6.58 ChEMBL