[3H]naloxone


SMILES C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O
InChIKey UZHSEJADLWPNLE-GRGSLBFTSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Molecular weight (Da) 327.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Rat Opioid A pKd 8.55 8.78 9.0 Guide to Pharmacology
CCR5 CCR5 Mouse Chemokine A pKd 7.68 7.83 7.98 ChEMBL
κ OPRK Rat Opioid A pKd 8.35 8.68 9.0 ChEMBL
κ OPRK Mouse Opioid A pKd 6.9 6.9 6.9 ChEMBL
μ OPRM Mouse Opioid A pKd 7.99 7.99 7.99 ChEMBL
δ OPRD Mouse Opioid A pKd 7.3 7.32 7.35 ChEMBL
δ OPRD Rat Opioid A pKd 7.75 7.75 7.75 ChEMBL
δ OPRD Rat Opioid A pKi 6.99 7.89 8.62 ChEMBL
κ OPRK Guinea pig Opioid A pKi 7.18 8.01 8.51 ChEMBL
κ OPRK Guinea pig Opioid A pKd 7.7 7.7 7.7 ChEMBL
μ OPRM Rat Opioid A pKi 8.2 8.6 8.97 ChEMBL
μ OPRM Rat Opioid A pKd 8.3 8.74 9.4 ChEMBL
δ OPRD Human Opioid A pKi 5.82 7.21 7.8 ChEMBL
κ OPRK Human Opioid A pKi 6.44 8.18 9.6 ChEMBL
μ OPRM Human Opioid A pKi 6.45 8.46 9.64 ChEMBL
μ OPRM Human Opioid A pKd 9.66 9.66 9.66 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
μ OPRM Bovine Opioid A pIC50 8.3 8.3 8.3 ChEMBL
μ OPRM Mouse Opioid A pIC50 7.81 7.81 7.81 ChEMBL
κ OPRK Guinea pig Opioid A pIC50 7.3 7.3 7.3 ChEMBL
δ OPRD Human Opioid A pIC50 5.83 6.85 7.21 ChEMBL
κ OPRK Human Opioid A pEC50 8.0 8.09 8.18 ChEMBL
κ OPRK Human Opioid A pIC50 6.21 7.04 8.82 ChEMBL
μ OPRM Human Opioid A pIC50 4.48 7.43 8.73 ChEMBL
μ OPRM Human Opioid A pEC50 8.06 8.06 8.06 ChEMBL