[3H]N-methylspiperone


SMILES Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)N(CN(C2=O)C)c1ccccc1
InChIKey QHJLPOSPWKZACG-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 6
Molecular weight (Da) 409.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Rat Dopamine A pKi 10.7 10.7 10.7 Guide to Pharmacology
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKd 9.1 9.1 9.1 Guide to Pharmacology
D2 DRD2 Rat Dopamine A pKi 9.93 9.93 9.93 ChEMBL
D2 DRD2 Rat Dopamine A pKd 10.01 10.01 10.01 ChEMBL
D4 DRD4 Human Dopamine A pKd 8.52 8.92 9.32 ChEMBL
D4 DRD4 Human Dopamine A pKi 8.82 8.84 8.85 ChEMBL
D3 DRD3 Human Dopamine A pKi 9.58 9.58 9.58 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.06 8.06 8.06 ChEMBL
D2 DRD2 Human Dopamine A pKd 10.01 10.1 10.15 ChEMBL
D2 DRD2 Human Dopamine A pKi 9.34 9.52 9.88 ChEMBL
D4 DRD4 Rat Dopamine A pKi 9.5 9.5 9.5 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α1A ADA1A Rat Adrenoceptors A pIC50 8.0 8.0 8.0 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 9.64 9.64 9.64 ChEMBL