[3H]histamine
| SMILES | NCCc1cnc[nH]1 |
| InChIKey | NTYJJOPFIAHURM-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 2 |
| Hydrogen bond donors | 2 |
| Rotatable bonds | 2 |
| Molecular weight (Da) | 111.1 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Surrogate |
| Approved drug | Yes |
Database connections
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| H3 | HRH3 | Human | Histamine | A | pKd | 8.0 | 8.0 | 8.0 | Guide to Pharmacology |
| H4 | HRH4 | Human | Histamine | A | pKd | 7.4 | 7.9 | 8.4 | Guide to Pharmacology |
| H4 | HRH4 | Mouse | Histamine | A | pKd | 7.4 | 7.4 | 7.4 | Guide to Pharmacology |
| H4 | HRH4 | Rat | Histamine | A | pKd | 6.9 | 6.9 | 6.9 | Guide to Pharmacology |
| H4 | Q91ZY3 | Guinea pig | Histamine | A | pKi | 8.22 | 8.22 | 8.22 | ChEMBL |
| H4 | HRH4 | Mouse | Histamine | A | pKd | 7.38 | 7.38 | 7.38 | ChEMBL |
| H4 | HRH4 | Mouse | Histamine | A | pKi | 5.67 | 6.61 | 7.38 | ChEMBL |
| H1 | HRH1 | Rat | Histamine | A | pKd | 8.0 | 8.0 | 8.0 | ChEMBL |
| H4 | HRH4 | Rat | Histamine | A | pKi | 6.87 | 7.04 | 7.2 | ChEMBL |
| H4 | HRH4 | Rat | Histamine | A | pKd | 6.87 | 6.87 | 6.87 | ChEMBL |
| H3 | HRH3 | Mouse | Histamine | A | pKi | 7.17 | 7.17 | 7.17 | ChEMBL |
| H2 | HRH2 | Guinea pig | Histamine | A | pKd | 4.16 | 4.16 | 4.16 | ChEMBL |
| H1 | HRH1 | Guinea pig | Histamine | A | pKd | 8.0 | 8.91 | 9.11 | ChEMBL |
| H1 | HRH1 | Guinea pig | Histamine | A | pKi | 4.9 | 4.9 | 4.9 | ChEMBL |
| H3 | HRH3 | Rat | Histamine | A | pKi | 8.2 | 8.2 | 8.2 | ChEMBL |
| H4 | HRH4 | Human | Histamine | A | pKi | 6.66 | 7.72 | 9.0 | ChEMBL |
| H4 | HRH4 | Human | Histamine | A | pKd | 7.8 | 8.05 | 8.3 | ChEMBL |
| H2 | HRH2 | Human | Histamine | A | pKi | 4.3 | 5.75 | 6.58 | ChEMBL |
| H2 | HRH2 | Human | Histamine | A | pKd | 7.91 | 7.91 | 7.91 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pKi | 4.1 | 4.8 | 5.62 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pKd | 8.35 | 8.35 | 8.35 | ChEMBL |
| H3 | HRH3 | Human | Histamine | A | pKi | 5.93 | 7.46 | 8.6 | ChEMBL |
| H3 | HRH3 | Human | Histamine | A | pKd | 8.52 | 8.52 | 8.52 | ChEMBL |
| H3 | HRH3 | Guinea pig | Histamine | A | pKi | 7.98 | 8.91 | 9.84 | ChEMBL |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| H4 | HRH4 | Mouse | Histamine | A | pEC50 | 5.17 | 6.13 | 7.06 | ChEMBL |
| H1 | HRH1 | Rat | Histamine | A | pEC50 | 5.35 | 5.35 | 5.35 | ChEMBL |
| H4 | HRH4 | Rat | Histamine | A | pEC50 | 4.28 | 5.76 | 6.8 | ChEMBL |
| H2 | HRH2 | Guinea pig | Histamine | A | pEC50 | 5.92 | 6.06 | 6.6 | ChEMBL |
| H1 | HRH1 | Guinea pig | Histamine | A | pEC50 | 6.7 | 6.73 | 6.79 | ChEMBL |
| H3 | HRH3 | Rat | Histamine | A | pEC50 | 7.21 | 7.21 | 7.21 | ChEMBL |
| H4 | HRH4 | Human | Histamine | A | pEC50 | 5.75 | 7.66 | 8.13 | ChEMBL |
| H2 | HRH2 | Human | Histamine | A | pEC50 | 5.26 | 5.94 | 6.94 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pIC50 | 6.8 | 6.8 | 6.8 | ChEMBL |
| H1 | HRH1 | Human | Histamine | A | pEC50 | 6.7 | 6.92 | 7.89 | ChEMBL |
| H3 | HRH3 | Human | Histamine | A | pEC50 | 6.19 | 7.77 | 8.6 | ChEMBL |
| TSH | TSHR | Human | Glycoprotein hormone | A | Potency | 4.5 | 4.5 | 4.5 | ChEMBL |