[3H]fananserin


SMILES Fc1ccc(cc1)N1CCN(CC1)CCCN1c2cccc3c2c(S1(=O)=O)ccc3
InChIKey VGIGHGMPMUCLIQ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 5
Molecular weight (Da) 425.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKd 9.9 9.9 9.9 Guide to Pharmacology
H1 HRH1 Guinea pig Histamine A pKi 7.6 7.6 7.6 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 6.07 6.07 6.07 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 7.42 7.42 7.42 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 6.18 6.18 6.18 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 5.99 5.99 5.99 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.13 6.13 6.13 ChEMBL
H1 HRH1 Human Histamine A pKi 7.51 7.51 7.51 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 7.16 7.16 7.16 ChEMBL
D4 DRD4 Human Dopamine A pKi 7.02 8.03 8.54 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 6.71 6.71 6.71 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 5.7 5.7 5.7 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.29 5.29 5.29 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.3 8.15 9.0 ChEMBL
D3 DRD3 Human Dopamine A pKi 5.99 5.99 5.99 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.32 9.64 10.4 ChEMBL
κ OPRK Human Opioid A pKi 5.54 5.54 5.54 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.75 6.75 6.75 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.29 6.29 6.29 ChEMBL
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 5.17 5.17 5.17 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database