[3H]brimonidine (UK14304)


SMILES Brc1c(ccc2c1nccn2)NC1=NCCN1
InChIKey XYLJNLCSTIOKRM-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 1
Molecular weight (Da) 291.0

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2A ADA2A Human Adrenoceptors A pKd 9.1 9.1 9.1 Guide to Pharmacology
α2B ADA2B Rat Adrenoceptors A pKi 7.28 7.28 7.28 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 5.27 5.32 5.38 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 5.59 5.59 5.59 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 5.68 5.93 6.07 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 6.32 6.74 7.46 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 6.24 6.89 7.36 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 5.96 5.96 5.96 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 5.84 5.84 5.84 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 5.55 5.55 5.55 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.71 7.6 8.57 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2B ADA2B Rat Adrenoceptors A pEC50 7.26 7.26 7.26 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 5.2 5.2 5.2 ChEMBL
α1D ADA1D Human Adrenoceptors A pIC50 5.76 5.76 5.76 ChEMBL
α2B ADA2B Human Adrenoceptors A pEC50 6.55 6.55 6.55 ChEMBL
α2B ADA2B Human Adrenoceptors A pIC50 5.98 5.98 5.98 ChEMBL
α2C ADA2C Human Adrenoceptors A pEC50 8.02 8.2 8.47 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 5.59 5.59 5.59 ChEMBL
α2A ADA2A Human Adrenoceptors A pEC50 8.39 8.86 9.21 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 6.53 6.53 6.53 ChEMBL
α1A ADA1A Bovine Adrenoceptors A pEC50 5.95 5.95 5.95 ChEMBL