[3H]8-OH-DPAT
| SMILES | CCCN(C1CCc2c(C1)c(O)ccc2)CCC |
| InChIKey | ASXGJMSKWNBENU-UHFFFAOYSA-N |
Chemical properties
| Hydrogen bond acceptors | 2 |
| Hydrogen bond donors | 1 |
| Rotatable bonds | 5 |
| Molecular weight (Da) | 247.2 |
Drug properties
| Molecular type | Small molecule |
| Physiological/Surrogate | Surrogate |
| Approved drug | No |
Database connections
Bioactivities
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKd | 6.0 | 7.7 | 9.4 | Guide to Pharmacology |
| 5-HT1B | 5HT1B | Human | 5-Hydroxytryptamine | A | pKd | 8.9 | 8.9 | 8.9 | Guide to Pharmacology |
| 5-HT1D | 5HT1D | Human | 5-Hydroxytryptamine | A | pKd | 9.0 | 9.0 | 9.0 | Guide to Pharmacology |
| D1 | DRD1 | Bovine | Dopamine | A | pKi | 4.06 | 4.06 | 4.06 | ChEMBL |
| D2 | DRD2 | Bovine | Dopamine | A | pKi | 5.62 | 5.62 | 5.62 | ChEMBL |
| D3 | DRD3 | Rat | Dopamine | A | pKi | 6.48 | 6.56 | 6.61 | ChEMBL |
| α1D | ADA1D | Rat | Adrenoceptors | A | pKi | 5.27 | 5.27 | 5.27 | ChEMBL |
| 5-HT5A | 5HT5A | Human | 5-Hydroxytryptamine | A | pKi | 5.6 | 5.73 | 6.0 | ChEMBL |
| 5-HT7 | 5HT7R | Rat | 5-Hydroxytryptamine | A | pKi | 6.82 | 6.82 | 6.82 | ChEMBL |
| 5-HT1B | 5HT1B | Rat | 5-Hydroxytryptamine | A | pKi | 4.2 | 4.89 | 5.59 | ChEMBL |
| 5-HT1B | 5HT1B | Human | 5-Hydroxytryptamine | A | pKi | 6.2 | 6.22 | 6.25 | ChEMBL |
| α1B | ADA1B | Human | Adrenoceptors | A | pKi | 5.22 | 5.39 | 5.72 | ChEMBL |
| 5-HT7 | 5HT7R | Human | 5-Hydroxytryptamine | A | pKi | 6.3 | 6.37 | 6.41 | ChEMBL |
| D2 | DRD2 | Rat | Dopamine | A | pKi | 5.46 | 6.18 | 7.07 | ChEMBL |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKi | 6.01 | 8.78 | 9.57 | ChEMBL |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pKd | 8.6 | 8.6 | 8.6 | ChEMBL |
| α1A | ADA1A | Human | Adrenoceptors | A | pKi | 5.75 | 6.29 | 6.82 | ChEMBL |
| 5-HT2C | 5HT2C | Human | 5-Hydroxytryptamine | A | pKi | 4.83 | 4.98 | 5.14 | ChEMBL |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pKi | 5.4 | 8.74 | 9.8 | ChEMBL |
| D2 | DRD2 | Human | Dopamine | A | pKi | 5.49 | 6.68 | 7.08 | ChEMBL |
| 5-HT1D | 5HT1D | Human | 5-Hydroxytryptamine | A | pKi | 6.79 | 6.87 | 6.94 | ChEMBL |
| D3 | DRD3 | Human | Dopamine | A | pKi | 4.84 | 5.71 | 6.59 | ChEMBL |
| α1A | ADA1A | Rat | Adrenoceptors | A | pKi | 5.68 | 5.68 | 5.68 | ChEMBL |
| Receptor | Activity | Source | |||||||
|---|---|---|---|---|---|---|---|---|---|
| GTP | Uniprot | Species | Family | Class | Type | Min | Avg | Max | Database |
| 5-HT2A | 5HT2A | Bovine | 5-Hydroxytryptamine | A | pIC50 | 4.31 | 4.31 | 4.31 | ChEMBL |
| α1A | ADA1A | Bovine | Adrenoceptors | A | pIC50 | 4.52 | 4.52 | 4.52 | ChEMBL |
| D2 | DRD2 | Bovine | Dopamine | A | pIC50 | 6.1 | 6.1 | 6.1 | ChEMBL |
| 5-HT1B | 5HT1B | Rat | 5-Hydroxytryptamine | A | pIC50 | 5.42 | 5.42 | 5.42 | ChEMBL |
| 5-HT1B | 5HT1B | Human | 5-Hydroxytryptamine | A | pEC50 | 6.58 | 6.58 | 6.58 | ChEMBL |
| D2 | DRD2 | Rat | Dopamine | A | pIC50 | 5.24 | 6.76 | 8.28 | ChEMBL |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pIC50 | 7.85 | 8.52 | 8.96 | ChEMBL |
| 5-HT1A | 5HT1A | Rat | 5-Hydroxytryptamine | A | pEC50 | 7.85 | 7.85 | 7.85 | ChEMBL |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pIC50 | 8.22 | 9.16 | 9.55 | ChEMBL |
| 5-HT1A | 5HT1A | Human | 5-Hydroxytryptamine | A | pEC50 | 7.29 | 7.88 | 8.59 | ChEMBL |
| α2A | ADA2A | Bovine | Adrenoceptors | A | pIC50 | 6.0 | 6.0 | 6.0 | ChEMBL |