[11C]pyrilamine


SMILES COc1ccc(cc1)CN(c1ccccn1)CCN(C)C
InChIKey YECBIJXISLIIDS-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 7
Molecular weight (Da) 285.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Guinea pig Histamine A pKd 8.84 9.12 9.5 ChEMBL
H1 HRH1 Human Histamine A pKi 8.35 8.79 9.37 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 5.95 5.95 5.95 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.75 5.75 5.75 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.23 6.23 6.23 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.54 6.54 6.54 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Rat Histamine A pIC50 8.24 8.24 8.24 ChEMBL
H1 HRH1 Guinea pig Histamine A pIC50 7.47 8.14 8.82 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.8 4.88 4.95 ChEMBL
H1 HRH1 Human Histamine A pIC50 6.8 8.51 10.85 ChEMBL
H1 HRH1 Human Histamine A pEC50 8.59 8.59 8.59 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 5.53 5.53 5.53 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 5.55 5.55 5.55 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 5.95 5.95 5.95 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 6.0 6.0 6.0 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.4 4.83 5.3 ChEMBL