[11C]doxepin


SMILES CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C
InChIKey ODQWQRRAPPTVAG-GZTJUZNOSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 3
Molecular weight (Da) 279.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H1 HRH1 Human Histamine A pKd 9.0 9.0 9.0 Guide to Pharmacology
H1 HRH1 Human Histamine A pKi 9.6 9.68 9.75 ChEMBL
H1 HRH1 Human Histamine A pKd 9.2 9.2 9.2 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.6 7.6 7.6 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 6.05 6.45 6.85 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 8.7 8.7 8.7 ChEMBL