(-)-sulpiride


SMILES CCN1CCC[C@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N
InChIKey BGRJTUBHPOOWDU-NSHDSACASA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 6
Molecular weight (Da) 341.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Ligand site mutations D1 D2 D4

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Human Dopamine A pKi 6.28 7.36 8.0 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 6.68 7.27 7.85 Guide to Pharmacology
D4 DRD4 Human Dopamine A pKi 5.72 6.71 7.7 Guide to Pharmacology
D1 DRD1 Bovine Dopamine A pKi 4.3 4.3 4.3 ChEMBL
D2 DRD2 Rat Dopamine A pKi 6.62 7.58 8.26 ChEMBL
D2 DRD2 Rat Dopamine A pKd 8.82 8.82 8.82 ChEMBL
D4 DRD4 Human Dopamine A pKi 5.68 5.68 5.68 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.12 6.12 6.12 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.92 7.29 8.1 ChEMBL
D3 DRD3 Human Dopamine A pKd 7.4 7.4 7.4 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.92 7.33 8.12 ChEMBL
D2 DRD2 Human Dopamine A pKd 8.55 8.55 8.55 ChEMBL
D2 DRD2 Human Dopamine A pKi 8.09 8.12 8.14 Drug Central
D3 DRD3 Human Dopamine A pKi 8.09 8.12 8.15 Drug Central
D4 DRD4 Human Dopamine A pKi 8.25 8.25 8.25 Drug Central
D1 DRD1 Bovine Dopamine A pKi 8.37 8.37 8.37 Drug Central
D2 DRD2 Rat Dopamine A pKi 8.09 8.09 8.09 Drug Central
D2 DRD2 Rat Dopamine A pKd 8.05 8.05 8.05 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.21 8.21 8.21 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Rat Dopamine A pIC50 6.63 6.9 7.48 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 5.7 5.7 5.7 ChEMBL
D3 DRD3 Human Dopamine A pIC50 6.25 6.85 7.18 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.8 4.8 4.8 ChEMBL
D2 DRD2 Human Dopamine A pIC50 6.69 7.24 7.99 ChEMBL
D2 DRD2 Dog Dopamine A pIC50 8.17 8.17 8.17 Drug Central
D2 DRD2 Dog Dopamine A pIC50 6.7 6.7 6.7 ChEMBL