(-)-stepholidine


SMILES COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O
InChIKey JKPISQIIWUONPB-HNNXBMFYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Molecular weight (Da) 327.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Human Dopamine A pKi 8.29 8.29 8.29 Guide to Pharmacology
D2 DRD2 Human Dopamine A pKi 7.94 7.94 7.94 Guide to Pharmacology
D5 DRD5 Human Dopamine A pKi 8.24 8.24 8.24 Guide to Pharmacology
D5 DRD5 Human Dopamine A pKi 8.24 8.3 8.36 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 5.65 5.65 5.65 ChEMBL
D4 DRD4 Human Dopamine A pKi 5.43 5.63 5.84 ChEMBL
D1 DRD1 Human Dopamine A pKi 7.91 8.22 8.47 ChEMBL
D3 DRD3 Human Dopamine A pKi 7.05 7.45 7.63 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.01 6.88 7.96 ChEMBL
D3 DRD3 Rat Dopamine A pKi 7.52 7.52 7.52 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Rat Dopamine A pEC50 4.39 4.39 4.39 ChEMBL
D1 DRD1 Human Dopamine A pIC50 7.91 7.91 7.91 ChEMBL
D1 DRD1 Human Dopamine A pEC50 7.64 7.64 7.64 ChEMBL
D2 DRD2 Human Dopamine A pIC50 5.36 6.17 6.98 ChEMBL