spiramide


SMILES Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1
InChIKey FJUKDAZEABGEIH-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 383.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.6 7.6 7.6 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 Guide to Pharmacology
D1 DRD1 Mouse Dopamine A pKi 5.6 5.6 5.6 ChEMBL
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 5.37 5.37 5.37 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.89 5.89 5.89 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 6.53 6.53 6.53 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 6.42 6.42 6.42 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 6.53 6.53 6.53 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 6.12 6.12 6.12 ChEMBL
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 5.88 5.88 5.88 ChEMBL
β1 ADRB1 Human Adrenoceptors A pKi 5.5 5.5 5.5 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.47 6.47 6.47 ChEMBL
H1 HRH1 Human Histamine A pKi 6.51 6.51 6.51 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 7.3 7.3 7.3 ChEMBL
D4 DRD4 Human Dopamine A pKi 8.33 8.33 8.33 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 6.39 6.39 6.39 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 5.64 5.64 5.64 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.39 6.39 6.39 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.94 5.94 5.94 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.41 6.41 6.41 ChEMBL
D3 DRD3 Human Dopamine A pKi 7.49 7.49 7.49 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.82 7.82 7.82 ChEMBL
κ OPRK Human Opioid A pKi 6.04 6.04 6.04 ChEMBL
μ OPRM Human Opioid A pKi 6.81 6.81 6.81 ChEMBL
D2 DRD2 Human Dopamine A pKi 8.02 8.27 8.52 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.8 5.8 5.8 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GPR183 GP183 Human Orphan A pIC50 5.32 5.32 5.32 ChEMBL
β2 ADRB2 Human Adrenoceptors A pIC50 5.52 5.52 5.52 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 9.5 9.5 9.5 ChEMBL