SKF-83566


SMILES CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O
InChIKey XFTVOHWWEQGXLS-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Molecular weight (Da) 331.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Human Dopamine A pKi 9.5 9.5 9.5 Guide to Pharmacology
D5 DRD5 Human Dopamine A pKi 9.4 9.4 9.4 Guide to Pharmacology
D5 DRD5 Human Dopamine A pKi 8.4 8.63 8.76 ChEMBL
D1 DRD1 Rat Dopamine A pKd 8.63 8.63 8.63 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.55 5.55 5.55 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 5.66 5.66 5.66 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 6.1 6.1 6.1 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.56 6.56 6.56 ChEMBL
H1 HRH1 Human Histamine A pKi 6.12 6.12 6.12 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 5.83 5.83 5.83 ChEMBL
D1 DRD1 Human Dopamine A pKi 8.54 9.1 9.52 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.51 7.51 7.51 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.92 7.92 7.92 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.9 6.9 6.9 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 5.54 5.54 5.54 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.87 5.87 5.87 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Human Dopamine A pIC50 5.65 5.65 5.65 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.8 4.8 4.8 ChEMBL