SKF-82958


SMILES C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O
InChIKey HJWHHQIVUHOBQN-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Molecular weight (Da) 329.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations D1 D2

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D2 DRD2 Rat Dopamine A pKd 5.8 6.12 6.4 ChEMBL
D1 DRD1 Human Dopamine A pKi 7.7 7.98 8.26 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.89 6.48 7.26 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Rat Dopamine A pIC50 8.29 8.29 8.29 ChEMBL
D1 DRD1 Rat Dopamine A pEC50 6.31 6.31 6.31 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.55 4.55 4.55 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 6.47 6.47 6.47 ChEMBL
D1 DRD1 Human Dopamine A pEC50 8.7 8.92 9.14 ChEMBL