SKF-81297


SMILES Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1
InChIKey GHWJEDJMOVUXEC-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 1
Molecular weight (Da) 289.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Structure pdb 7LJC 7JV5

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Rat Dopamine A pKi 8.7 8.7 8.7 Guide to Pharmacology
D2 DRD2 Rat Dopamine A pKd 4.89 5.21 5.52 ChEMBL
D1 DRD1 Human Dopamine A pKi 7.52 7.83 8.15 ChEMBL
D2 DRD2 Human Dopamine A pKi 5.1 5.57 6.51 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
GAL3 GALR3 Human Galanin A pIC50 5.42 5.42 5.42 ChEMBL
D5 DRD5 Human Dopamine A pEC50 8.85 8.85 8.85 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.8 4.8 4.8 ChEMBL
D1 DRD1 Human Dopamine A pEC50 5.02 7.02 8.7 ChEMBL
TA1 TAAR1 Human Trace amine A pEC50 5.18 5.18 5.18 ChEMBL