(S)-dimetindene


SMILES CN(CCC1=C([C@@H](c2ccccn2)C)c2c(C1)cccc2)C
InChIKey MVMQESMQSYOVGV-OAHLLOKOSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 5
Molecular weight (Da) 292.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 6.72 6.72 6.72 Guide to Pharmacology
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 7.52 7.52 7.52 Guide to Pharmacology
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 6.86 6.86 6.86 Guide to Pharmacology
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 6.53 6.53 6.53 Guide to Pharmacology
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 6.12 6.12 6.12 Guide to Pharmacology
H1 HRH1 Human Histamine A pKi 7.16 7.16 7.16 Guide to Pharmacology
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 5.57 5.93 6.12 ChEMBL
H1 HRH1 Human Histamine A pKi 7.16 8.77 9.4 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 5.41 6.11 6.53 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 5.47 6.35 6.86 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 5.91 6.93 7.52 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 5.73 6.91 8.62 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.19 8.19 8.19 Drug Central
M5 ACM5 Human Acetylcholine (muscarinic) A pKi 8.21 8.21 8.21 Drug Central
H1 HRH1 Human Histamine A pKi 8.04 8.04 8.04 Drug Central
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.18 8.18 8.18 Drug Central
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.13 8.13 8.13 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.17 8.17 8.17 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
TSH TSHR Human Glycoprotein hormone A Potency 4.4 4.4 4.4 ChEMBL