SB 204070


SMILES CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N
InChIKey AOOSJYIINXVNHV-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 382.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT4 5HT4R Human 5-Hydroxytryptamine A pKi 9.8 10.11 10.41 Guide to Pharmacology
5-HT4 5HT4R Rat 5-Hydroxytryptamine A pKi 8.9 9.2 9.5 Guide to Pharmacology
5-HT4 5HT4R Human 5-Hydroxytryptamine A pKi 10.8 10.8 10.8 ChEMBL
5-HT4 5HT4R Guinea pig 5-Hydroxytryptamine A pKi 10.89 10.89 10.89 ChEMBL
5-HT4 5HT4R Guinea pig 5-Hydroxytryptamine A pKd 10.7 10.7 10.7 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 5.42 5.42 5.42 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 6.17 6.17 6.17 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 5.73 5.73 5.73 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 5.82 5.82 5.82 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.28 7.28 7.28 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.2 6.73 7.1 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 6.02 6.02 6.02 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.17 6.17 6.17 ChEMBL
H1 HRH1 Human Histamine A pKi 5.33 5.33 5.33 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT4 5HT4R Guinea pig 5-Hydroxytryptamine A pIC50 10.0 10.07 10.1 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.85 5.05 5.25 ChEMBL
NPS NPSR1 Human Neuropeptide S A Potency 7.6 7.6 7.6 ChEMBL