ritanserin


SMILES Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F
InChIKey JUQLTPCYUFPYKE-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 0
Rotatable bonds 5
Molecular weight (Da) 477.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 6BQH
Ligand site mutations 5-HT1A 5-HT2A 5-HT2C 5-HT6

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 7.6 7.6 7.6 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.850000000000001 8.85 8.85 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.7 8.95 9.2 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.2 8.9 9.6 Guide to Pharmacology
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 7.6 7.6 7.6 Guide to Pharmacology
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 7.0 7.2 7.4 Guide to Pharmacology
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.8 7.1 7.4 Guide to Pharmacology
α1A ADA1A Human Adrenoceptors A pKi 8.4 8.4 8.4 Guide to Pharmacology
α1B ADA1B Human Adrenoceptors A pKi 8.0 8.0 8.0 Guide to Pharmacology
α1D ADA1D Human Adrenoceptors A pKi 7.8 7.8 7.8 Guide to Pharmacology
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 6.5 7.15 7.8 Guide to Pharmacology
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 9.2 9.2 9.2 Guide to Pharmacology
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.7 7.75 7.8 Guide to Pharmacology
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 8.3 8.3 8.3 Guide to Pharmacology
5-HT5A 5HT5A Mouse 5-Hydroxytryptamine A pKi 7.4 7.4 7.4 Guide to Pharmacology
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.8 7.81 7.82 ChEMBL
D5 DRD5 Human Dopamine A pKi 6.31 6.31 6.31 ChEMBL
H1 HRH1 Guinea pig Histamine A pKi 8.22 8.22 8.22 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.55 6.55 6.55 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 6.22 6.22 6.22 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 6.18 6.18 6.18 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 6.43 6.43 6.43 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.33 7.49 7.8 ChEMBL
D2 DRD2 Rat Dopamine A pKi 7.03 7.63 8.52 ChEMBL
H1 HRH1 Human Histamine A pKi 7.92 7.92 7.92 ChEMBL
D4 DRD4 Human Dopamine A pKi 6.62 6.62 6.62 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 6.76 6.76 6.76 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.43 6.43 6.43 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.54 6.54 6.54 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.48 6.48 6.48 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.39 8.86 9.15 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKd 6.6 6.6 6.6 ChEMBL
D3 DRD3 Human Dopamine A pKi 7.45 7.45 7.45 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.38 8.98 9.35 ChEMBL
κ OPRK Human Opioid A pKi 5.84 5.84 5.84 ChEMBL
μ OPRM Human Opioid A pKi 6.46 6.46 6.46 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.74 6.74 6.74 ChEMBL
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 6.25 6.25 6.25 ChEMBL
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 6.99 6.99 6.99 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pIC50 5.2 5.35 5.5 Guide to Pharmacology
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pIC50 6.0 6.25 6.5 Guide to Pharmacology
FPR3 FPR3 Human Formylpeptide A pIC50 5.25 5.25 5.25 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 7.33 7.33 7.33 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.8 5.15 5.5 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 7.64 7.88 7.92 ChEMBL
β2 ADRB2 Human Adrenoceptors A pEC50 5.35 5.35 5.35 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.4 4.4 4.4 ChEMBL
NPS NPSR1 Human Neuropeptide S A Potency 4.7 5.5 6.3 ChEMBL
TAS2R20 T2R20 Human Taste 2 T2 pEC50 5.22 5.22 5.22 Guide to Pharmacology