risperidone


SMILES Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2
InChIKey RAPZEAPATHNIPO-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 0
Rotatable bonds 4
Molecular weight (Da) 410.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 6CM4 6A93
Ligand site mutations 5-HT2A D2

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKd 8.9 8.95 9.0 Guide to Pharmacology
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.4 6.45 6.5 Guide to Pharmacology
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 6.6 6.95 7.3 Guide to Pharmacology
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 7.8 7.9 8.0 Guide to Pharmacology
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 5.9 5.9 5.9 Guide to Pharmacology
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 5.9 5.9 5.9 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 9.3 9.65 10.0 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.5 7.55 7.6 Guide to Pharmacology
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.3 8.5 8.7 Guide to Pharmacology
α1A ADA1A Human Adrenoceptors A pKi 8.4 8.55 8.7 Guide to Pharmacology
α1B ADA1B Human Adrenoceptors A pKi 7.8 7.9 8.0 Guide to Pharmacology
α1D ADA1D Human Adrenoceptors A pKi 7.4 7.4 7.4 Guide to Pharmacology
α2A ADA2A Human Adrenoceptors A pKi 7.3 7.3 7.3 Guide to Pharmacology
D2 DRD2 Human Dopamine A pKi 9.36 9.36 9.36 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 7.0 7.0 7.0 Guide to Pharmacology
H1 HRH1 Human Histamine A pKi 7.6 7.7 7.8 Guide to Pharmacology
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 6.0 6.2 6.4 Guide to Pharmacology
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 8.5 8.5 8.5 Guide to Pharmacology
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.2 6.2 6.2 Guide to Pharmacology
α2A ADA2A Rat Adrenoceptors A pKi 7.6 7.6 7.6 ChEMBL
H1 HRH1 Rat Histamine A pKi 6.77 6.77 6.77 ChEMBL
β1 ADRB1 Rat Adrenoceptors A pKi 4.66 4.66 4.66 ChEMBL
D3 DRD3 Rat Dopamine A pKi 7.5 7.84 8.01 ChEMBL
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 6.9 7.51 7.84 ChEMBL
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 ChEMBL
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.39 8.15 8.85 ChEMBL
D5 DRD5 Human Dopamine A pKi 6.0 6.0 6.0 ChEMBL
D1 DRD1 Rat Dopamine A pKi 6.6 7.1 7.66 ChEMBL
H1 HRH1 Guinea pig Histamine A pKi 7.33 7.55 8.1 ChEMBL
α1B ADA1B Rat Adrenoceptors A pKi 8.97 8.97 8.97 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.0 6.0 6.0 ChEMBL
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 8.0 8.0 8.0 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 8.0 8.0 8.0 ChEMBL
α1A ADA1A Rat Adrenoceptors A pKi 7.89 8.78 9.4 ChEMBL
α1D ADA1D Human Adrenoceptors A pKi 8.31 8.31 8.31 ChEMBL
α2B ADA2B Human Adrenoceptors A pKi 6.0 6.96 7.92 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 8.0 8.45 8.86 ChEMBL
H2 HRH2 Human Histamine A pKi 5.84 5.84 5.84 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.0 8.69 9.4 ChEMBL
H1 HRH1 Human Histamine A pKi 7.0 7.67 8.59 ChEMBL
D2 DRD2 Rat Dopamine A pKi 7.72 8.37 8.74 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.14 6.63 6.89 ChEMBL
D4 DRD4 Human Dopamine A pKi 7.0 7.86 8.21 ChEMBL
α1A ADA1A Human Adrenoceptors A pKi 8.0 8.42 8.64 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 6.0 7.5 8.44 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.7 5.97 6.65 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.0 6.6 7.68 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.54 7.69 7.82 ChEMBL
H3 HRH3 Human Histamine A pKi 5.96 5.96 5.96 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.0 7.71 8.61 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 5.55 5.55 5.55 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKd 6.4 6.4 6.4 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.93 6.61 7.68 ChEMBL
D3 DRD3 Human Dopamine A pKi 7.0 7.85 8.17 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 9.0 9.43 10.0 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 8.1 8.1 8.1 Drug Central
α2B ADA2B Human Adrenoceptors A pKi 8.11 8.11 8.11 Drug Central
β1 ADRB1 Human Adrenoceptors A pKi 8.28 8.28 8.28 Drug Central
β2 ADRB2 Human Adrenoceptors A pKi 8.28 8.28 8.28 Drug Central
D2 DRD2 Human Dopamine A pKi 7.94 8.44 9.36 ChEMBL
D1 DRD1 Human Dopamine A pKi 8.11 8.11 8.11 Drug Central
D2 DRD2 Human Dopamine A pKi 8.07 8.07 8.07 Drug Central
D3 DRD3 Human Dopamine A pKi 8.09 8.09 8.09 Drug Central
D5 DRD5 Human Dopamine A pKi 8.15 8.15 8.15 Drug Central
H1 HRH1 Human Histamine A pKi 8.13 8.13 8.13 Drug Central
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.19 8.19 8.19 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.03 8.03 8.03 Drug Central
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.13 8.13 8.13 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.11 8.11 8.11 Drug Central
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.07 8.07 8.07 Drug Central
α1A ADA1A Human Adrenoceptors A pKi 8.07 8.07 8.07 Drug Central
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 8.23 8.23 8.23 Drug Central
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 8.23 8.23 8.23 Drug Central
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 8.17 8.17 8.17 Drug Central
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 8.26 8.26 8.26 Drug Central
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 8.27 8.27 8.27 Drug Central
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 8.3 8.3 8.3 Drug Central
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.26 8.26 8.26 Drug Central
α1B ADA1B Human Adrenoceptors A pKi 8.07 8.07 8.07 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.07 8.07 8.07 Drug Central
D4 DRD4 Human Dopamine A pKi 8.1 8.1 8.1 Drug Central
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 8.19 8.19 8.19 Drug Central
D3 DRD3 Rat Dopamine A pKi 8.1 8.1 8.1 Drug Central
α1B ADA1B Rat Adrenoceptors A pKi 8.05 8.05 8.05 Drug Central
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 8.11 8.11 8.11 Drug Central
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 8.16 8.16 8.16 Drug Central
α1A ADA1A Rat Adrenoceptors A pKi 8.1 8.1 8.1 Drug Central
H1 HRH1 Guinea pig Histamine A pKi 8.12 8.12 8.12 Drug Central
D1 DRD1 Rat Dopamine A pKi 8.12 8.12 8.12 Drug Central
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 8.05 8.05 8.05 Drug Central
D2 DRD2 Rat Dopamine A pKi 8.06 8.06 8.06 Drug Central
β1 ADRB1 Rat Adrenoceptors A pKi 8.33 8.33 8.33 Drug Central
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 8.13 8.13 8.13 Drug Central
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.12 8.12 8.12 Drug Central
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.6 5.6 5.6 Guide to Pharmacology
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 8.18 8.18 8.18 Drug Central
α1D ADA1D Human Adrenoceptors A pKi 8.13 8.13 8.13 Drug Central
H2 HRH2 Human Histamine A pKi 8.16 8.16 8.16 Drug Central
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 8.01 8.01 8.01 Drug Central
α2A ADA2A Rat Adrenoceptors A pKi 8.12 8.12 8.12 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Mouse 5-Hydroxytryptamine A pIC50 6.37 6.37 6.37 ChEMBL
D2 DRD2 Mouse Dopamine A pIC50 7.64 7.64 7.64 ChEMBL
H1 HRH1 Rat Histamine A pIC50 7.1 7.1 7.1 ChEMBL
α1B ADA1B Rat Adrenoceptors A pIC50 8.71 8.71 8.71 ChEMBL
α1A ADA1A Rat Adrenoceptors A pIC50 9.01 9.01 9.01 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.75 4.83 4.9 ChEMBL
α1D ADA1D Human Adrenoceptors A pIC50 8.0 8.0 8.0 ChEMBL
α2B ADA2B Human Adrenoceptors A pIC50 7.58 7.58 7.58 ChEMBL
α2C ADA2C Human Adrenoceptors A pIC50 8.02 8.02 8.02 ChEMBL
H2 HRH2 Human Histamine A pIC50 5.83 5.83 5.83 ChEMBL
H1 HRH1 Human Histamine A pIC50 6.06 6.5 7.6 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 7.43 7.63 8.4 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pIC50 6.02 6.06 6.1 ChEMBL
α1A ADA1A Human Adrenoceptors A pIC50 7.96 7.98 8.0 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 8.01 8.01 8.01 ChEMBL
D1 DRD1 Human Dopamine A pIC50 6.32 6.32 6.32 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 7.64 7.64 7.64 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 7.82 8.39 8.74 ChEMBL
D3 DRD3 Human Dopamine A pIC50 7.62 7.62 7.62 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 8.33 8.88 9.46 ChEMBL
D2 DRD2 Human Dopamine A pIC50 7.7 8.08 8.44 ChEMBL
D2 DRD2 Mouse Dopamine A pIC50 8.12 8.12 8.12 Drug Central
5-HT1A 5HT1A Mouse 5-Hydroxytryptamine A pIC50 8.2 8.2 8.2 Drug Central
H1 HRH1 Rat Histamine A pIC50 8.15 8.15 8.15 Drug Central
TSH TSHR Human Glycoprotein hormone A Potency 5.1 5.1 5.1 ChEMBL