ranitidine


SMILES CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(o1)CN(C)C
InChIKey VMXUWOKSQNHOCA-UKTHLTGXSA-N

Chemical properties

Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 10
Molecular weight (Da) 314.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H2 HRH2 Human Histamine A pKi 7.1 7.1 7.1 Guide to Pharmacology
H2 HRH2 Rat Histamine A pKi 6.2 6.2 6.2 Guide to Pharmacology
H2 HRH2 Guinea pig Histamine A pKd 6.77 6.98 7.19 ChEMBL
H2 HRH2 Guinea pig Histamine A pKi 6.3 6.79 7.27 ChEMBL
H2 HRH2 Human Histamine A pKd 7.2 7.2 7.2 ChEMBL
H2 HRH2 Human Histamine A pKi 7.05 7.05 7.05 ChEMBL
H2 HRH2 Rat Histamine A pKi 8.21 8.21 8.21 Drug Central
H2 HRH2 Human Histamine A pKd 8.16 8.16 8.16 Drug Central
H2 HRH2 Guinea pig Histamine A pKd 8.14 8.14 8.14 Drug Central
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
H2 HRH2 Guinea pig Histamine A pIC50 5.47 5.47 5.47 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 5.1 5.1 5.1 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.8 4.8 4.8 ChEMBL