quinpirole


SMILES CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2
InChIKey FTSUPYGMFAPCFZ-ZWNOBZJWSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 2
Molecular weight (Da) 219.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Structure pdb 9R42
Ligand site mutations D2 D3 D4

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 5.8 5.8 5.8 Guide to Pharmacology
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.0 5.25 5.5 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 5.0 5.75 6.5 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 5.0 5.25 5.5 Guide to Pharmacology
D2 DRD2 Human Dopamine A pKi 4.9 6.3 7.7 Guide to Pharmacology
D3 DRD3 Human Dopamine A pKi 6.4 7.2 8.0 Guide to Pharmacology
D4 DRD4 Human Dopamine A pKi 7.5 7.5 7.5 Guide to Pharmacology
D3 DRD3 Rat Dopamine A pKi 7.3 7.55 7.8 Guide to Pharmacology
D2 DRD2 Rat Dopamine A pKi 5.2 5.2 5.2 Guide to Pharmacology
D2 DRD2 Bovine Dopamine A pKi 5.59 6.21 7.23 ChEMBL
D3 DRD3 Rat Dopamine A pKi 8.25 8.25 8.25 ChEMBL
D2 DRD2 Rat Dopamine A pKd 5.17 5.5 5.72 ChEMBL
D2 DRD2 Rat Dopamine A pKi 7.2 7.23 7.27 ChEMBL
D4 DRD4 Human Dopamine A pKi 7.28 8.07 8.74 ChEMBL
D1 DRD1 Human Dopamine A pKi 4.06 5.34 7.2 ChEMBL
β2 ADRB2 Human Adrenoceptors A pKi 4.0 4.0 4.0 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.38 7.56 9.39 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 4.6 4.6 4.6 ChEMBL
D2 DRD2 Human Dopamine A pKi 4.51 6.59 8.26 ChEMBL
D1 DRD1 Pig Dopamine A pKi 4.06 4.1 4.14 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D3 DRD3 Rat Dopamine A pEC50 7.1 7.93 8.77 ChEMBL
D3 DRD3 Rat Dopamine A pIC50 7.54 7.57 7.6 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 5.65 5.65 5.65 ChEMBL
D2 DRD2 Rat Dopamine A pEC50 7.32 7.95 8.66 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 5.32 5.89 7.0 ChEMBL
D4 DRD4 Human Dopamine A pEC50 7.08 8.0 8.85 ChEMBL
D4 DRD4 Human Dopamine A pIC50 7.48 7.48 7.48 ChEMBL
D3 DRD3 Human Dopamine A pEC50 6.73 8.49 10.01 ChEMBL
D3 DRD3 Human Dopamine A pIC50 7.57 7.57 7.57 ChEMBL
D2 DRD2 Human Dopamine A pEC50 5.55 7.53 9.03 ChEMBL
D2 DRD2 Human Dopamine A pIC50 6.33 7.46 8.58 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 5.2 5.2 5.2 ChEMBL